688 results on '"B. McClure"'
Search Results
2. Lessons Learned from Particulate Characterization Laboratory Anomalies
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Benjamin Greene, Karysta B Donisthorpe, and Mark B McClure
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Ground Support Systems and Facilities (Space) - Abstract
The White Sands Test Facility chemistry laboratory provides quality control for cleanroom operations including cleanliness verification of aerospace hardware by particulate counts and non-volatile residue determinations, particulate counts for liquid hypergolic propellants, gaseous helium and nitrogen propellant pressurizing agents used for ground support equipment and flight test article valve actuation, gaseous oxygen primarily used for component testing, and deionized water for refurbished propellant hardware flushing. Cleanliness verification includes particulate counts and non-volatile residue determinations to industry standard, NASA, and program specifications and levels. Particulate counts are typically to customer-specified specifications and levels including JPR 5322.1H (2016) Levels 50 and 100, Orion (MPCV 70156. Revision H (2018)) Level 100, RPTSTD-8070-0001 Revision 3 (2022), and IEST-STD-CC1246E (2013) Levels 50 and 100. The laboratory issues high pressure filter holders containing membrane filters to test operations personnel, who collect samples by flowing the required volumes of fluid through the filter holder, and the filter holder is returned to the lab for counting. A passing particulate count is required before testing may proceed. Rapid data reduction and issuing of reports indicating a pass or fail of the particulate specification are required. Corrective action and resampling invariably occurs if a sample fails. Consequently, the laboratory must maintain the highest degree of reliability to facilitate quality data used to decide if testing may proceed. Experience and continual improvements have enabled reliability. However, anomalies attributed to lab processes and hardware including filter holders, membranes, and Petri dishes have been encountered. This paper presents a summary of problems, solutions, successes, and lessons learned from particle counting experience for over 35 years.
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- 2024
3. Crowd-Sourced Technology Challenge for Improving Visual Color Detection of Hydrazine and Monomethylhydrazine Vapors in Spacecraft Environments
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Neil D Paz, Benjamin Greene, Ariana Guerrero, Mark B McClure, and Elijah Ugaddan
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Inorganic, Organic and Physical Chemistry - Abstract
NASA currently uses a visual colorimetric detection method for potential hydrazine, monomethylhydrazine (MMH), or unsymmetrical dimethylhydrazine (UDMH) contamination in the International Space Station. Astronauts exposed to propellants or their residues during extravehicular activities may transfer contaminants into the airlock. The colorimetric detection method employs the Contamination Detection Kit (CDK), which uses a potassium tetrachloroaurate redox reaction with the propellant hydrazine vapors and a color comparison card to determine airborne concentrations. Seeking ideas for improvement, the NASA Tournament Lab (NTL) crowdsourced a way to tackle the challenge of detecting hydrazine and MMH vapors using colorimetric detection methods. This Rid the Rocket competition drew over 200 participants and 20 submissions from around the world proposing innovative ways to develop a new chemical colorimetric detection method for hydrazine and MMH vapors on spacecraft. Using a phased approach to evaluate contestants, NASA eventually narrowed the field to five finalists from the United States, Romania, Taiwan, and India. Concept papers and hardware submissions were judged on feasibility, creativity, and ability to detect hydrazine and MMH vapors before being sent to the NASA White Sands Test Facility for laboratory evaluation. Finalists employed variations of sampling methods and color-detection chemistry using a variety of sampling pumps and indicator pads or solutions—including those employing potassium or hydrogen tetrachloroaurate, para-dimethylaminobenzaldehyde (PDAB), and modifiers including sodium metasilicate and cetyltrimethylammonium bromide—to enhance gold nanoparticle formation and surface plasmon resonance (SPR) resulting in visual blue to purple color development. This paper presents a summary of the crowdsourced submissions and results of laboratory testing.
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- 2024
4. 'Endless Possibilities' — Embodied Experiences and Connection in Social Salsa Dancing
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B. McClure
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Philosophy (General) ,B1-5802 - Abstract
This article offers an analysis of embodied experiences and connections in social salsa dancing. Framed within a theoretical context that views bodily practices as both the enactment of normative ideals and as a negotiation of personal freedom against normative ideals, social salsa dancing offers a rich empirical context to explore how we make sense of our bodies, bodily practices, and embodied experience. Drawing on fieldwork conducted as part of a doctoral study in addition to a decade of personal experience, I argue that social salsa dancing cultivates kinesthetic, tactile, and musical senses, and emphasizes the value of attentive embodied interactions and momentary connections with others. I conclude that exploring the possibilities of these interactions and connections offers a potentially emancipatory way of working on one’s embodied self.
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- 2014
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5. A Novel mHealth App for Smokers Living With HIV Who Are Ambivalent About Quitting Smoking: Formative Research and Randomized Feasibility Study
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Jennifer B McClure, Jaimee L Heffner, Chloe Krakauer, Sophia Mun, and Sheryl L Catz
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Medicine - Abstract
BackgroundMore people who smoke and are living with HIV now die from tobacco-related diseases than HIV itself. Most people are ambivalent about quitting smoking and want to quit someday but not yet. Scalable, effective interventions are needed to motivate and support smoking cessation among people ambivalent about quitting smoking (PAQS) who are living with HIV. ObjectiveThis study aims to develop an app-based intervention for PAQS who are living with HIV and assess its feasibility, acceptability, and potential impact. Results of this study will inform plans for future research and development. MethodsIn phase 1, PAQS living with HIV (n=8) participated in user-centered design interviews to inform the final intervention app design and recruitment plan for a subsequent randomized pilot study. In phase 2, PAQS living with HIV were randomized to either a standard care control app or a similar experimental app with additional content tailored for PAQS and those with HIV. Participants were followed for 3 months. Feasibility focused on recruitment, retention, and participants’ willingness to install the app. The study was not powered for statistical significance. Indices of acceptability (satisfaction and use) and impact (smoking behavior change and treatment uptake) were assessed via automated data and self-report among those who installed and used the app (n=19). ResultsRecruitment for both study phases was a challenge, particularly via web-based and social media platforms. Enrollment success was greater among people living with HIV recruited from a health care provider and research registry. Once enrolled, retention for the phase 2 randomized study was good; 74% (14/19) of the participants completed the 3-month follow-up. Phase 1 findings suggested that PAQS living with HIV were receptive to using an app-based intervention to help them decide whether, when, and how to stop smoking, despite not being ready to quit smoking. Phase 2 findings further supported this conclusion based on feedback from people who agreed to use an app, but group differences were observed. Indices of acceptability favored the experimental arm, including a descriptively higher mean number of sessions and utilization badges. Similarly, indices of potential impact were descriptively higher in the experimental arm (proportion reducing smoking, making a quit attempt, or calling free tobacco quitline). No participants in either arm quit smoking at the 3-month follow-up. ConclusionsOn the basis of this formative work, PAQS living with HIV may be receptive to using a mobile health–based app intervention to help them decide whether, when, or how to stop using tobacco. Indices of acceptability and impact indicate that additional research and development are warranted. Trial RegistrationClinicalTrials.gov NCT05339659; https://clinicaltrials.gov/study/NCT05339659
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- 2024
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6. Evidence and Reporting Standards in N-of-1 Medical Studies: A Systematic Review
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Prathiba Natesan Batley, Erica B. McClure, Brandy Brewer, Ateka A. Contractor, Nicholas John Batley, Larry Vernon Hedges, and Stephanie Chin
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N-of-1 trials, a special case of Single Case Experimental Designs (SCEDs), are prominent in clinical medical research and specifically psychiatry due to the growing significance of precision/personalized medicine. It is imperative that these clinical trials be conducted, and their data analyzed, using the highest standards to guard against threats to validity. This systematic review examined publications of medical N-of-1 trials to examine whether they meet (a) the evidence standards and (b) the criteria for demonstrating evidence of a relation between an independent and an outcome variable per the What Works Clearinghouse (WWC) standards for SCEDs. We also examined the appropriateness of the data analytic techniques in the special context of N-of-1 designs. We searched for empirical journal articles that used N-of-1 design and published between 2013 and 2022 in PubMed and Web of Science. Protocols or methodological papers and studies that did not manipulate a medical condition were excluded. We reviewed 115 articles; 4 (3.48%) articles met all WWC evidence standards. Most (99.1%) failed to report an appropriate design-comparable effect size; neither did they report a confidence/credible interval, and 47.9% reported neither the raw data rendering meta-analysis impossible. Most (83.8%) ignored autocorrelation and did not meet distributional assumptions (65.8%). These methodological problems could lead to significantly inaccurate effect sizes. It is necessary to implement stricter guidelines for the clinical conduct and analyses of medical N-of-1 trials. Reporting neither raw data nor design-comparable effect sizes renders meta-analysis impossible and is antithetical to the spirit of open science.
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- 2023
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7. Primary care physician beliefs and practices regarding blood pressure measurement: results from BP-CHECK qualitative interviews
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Clarissa Hsu, Laurel Hansell, Kelly Ehrlich, Sean Munson, Melissa Anderson, Karen L. Margolis, Jennifer B. McClure, Yoshio N. Hall, Matthew Thompson, Dwayne Joseph, and Beverly B. Green
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Blood pressure ,Diagnosis ,Measurement ,Provider attitudes ,Hypertension ,Kiosk ,Medicine (General) ,R5-920 - Abstract
Abstract Background Early identification and control of hypertension is critical to reducing cardiovascular disease events and death. U.S. Preventive Services Task Force guidelines recommend health care professionals screen all adults for hypertension, yet 1 in 4 adults with hypertension are unaware of their condition. This gap between guidelines and clinical practices highlights an important opportunity to improve blood pressure (BP) screening and hypertension diagnosis, including measurement outside of clinic settings. To identify targets for future diagnostic interventions, we sought to understand primary care physicians' (PCPs) beliefs and practices regarding use of common forms of BP measurement. Methods Study participants were PCPs (N = 27) who had patients enrolled in the BP-CHECK trial. The trial compared the accuracy of 24-h ambulatory BP monitoring (ABPM) to: 1) clinic-based monitoring, 2) home BP monitoring (HBPM), or 3) use of a BP kiosk in clinics or pharmacies. Physicians were interviewed by phone and compensated for their participation. Interviews were recorded, transcribed, and analyzed using a template analysis approach. Results Overall, PCPs preferred and trusted clinic BP measurement for diagnosing hypertension, particularly when measured with a manual sphygmomanometer. Concerns with HBPM included the belief that patients did not follow protocols for rest and body positioning at home, that home machines were not accurate, that home BPs could not be entered into the medical record, and that HBPM would make some patients anxious. Issues regarding kiosk measurement included beliefs that the public setting created stress for patients, that patients did not follow resting protocols when using kiosks, and concerns about the maintenance of these machines. ABPM was recognized as highly accurate but was not perceived as accessible. Additionally, some PCPs found it challenging to interpret the multiple readings generated by ABPM and HBPM, especially when these readings differed from clinic BPs. Conclusions Our findings suggest that both additional physician education and training and investments in equipment and system-level processes are needed to increase the acceptance and utilization of out of office BP measurement for identification and treatment of hypertension. These changes are needed to improve ensure everyone in the U.S receive optimal care for hypertension. Trial registration ClinicalTrials.gov NCT03130257 . Initial registration date: 4/21/2017.
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- 2023
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8. Inter- and intra-tumor heterogeneity of genetic and immune profiles in inherited renal cell carcinoma
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Mariko Tabata, Yusuke Sato, Yasunori Kogure, Marni B. McClure, Yuji Oshikawa-Kumade, Yuki Saito, Sumito Shingaki, Yuta Ito, Mitsuhiro Yuasa, Junji Koya, Kazushi Yoshida, Takashi Kohno, Yu Miyama, Teppei Morikawa, Kenichi Chiba, Ai Okada, Seishi Ogawa, Tetsuo Ushiku, Yuichi Shiraishi, Haruki Kume, and Keisuke Kataoka
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CP: Cancer ,Biology (General) ,QH301-705.5 - Abstract
Summary: Patients with von Hippel-Lindau disease (vHL) are at risk of developing spatially and temporally multiple clear cell renal cell carcinomas (ccRCCs), which offers a valuable opportunity to analyze inter- and intra-tumor heterogeneity of genetic and immune profiles within the same patient. Here, we perform whole-exome and RNA sequencing, digital gene expression, and immunohistochemical analyses for 81 samples from 51 ccRCCs of 10 patients with vHL. Inherited ccRCCs are clonally independent and have less genomic alterations than sporadic ccRCCs. Hierarchical clustering of transcriptome profiles shows two clusters with distinct immune signatures: immune hot and cold clusters. Interestingly, not only samples from the same tumors but also different tumors from the same patients tend to show a similar immune signature, whereas samples from different patients frequently exhibit different signatures. Our findings reveal the genetic and immune landscape of inherited ccRCCs, demonstrating the relevance of host factors in shaping anti-tumor immunity.
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- 2023
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9. Feasibility, Acceptability, and Potential Impact of a Novel mHealth App for Smokers Ambivalent About Quitting: Randomized Pilot Study
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Jennifer B McClure, Jaimee L Heffner, Chloe Krakauer, Sophia Mun, Predrag Klasnja, and Sheryl L Catz
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Information technology ,T58.5-58.64 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundMost smokers are ambivalent about quitting—they want to quit someday, but not now. Interventions are needed that can engage ambivalent smokers, build their motivation for quitting, and support future quit attempts. Mobile health (mHealth) apps offer a cost-effective platform for such interventions, but research is needed to inform their optimal design and assess their acceptability, feasibility, and potential effectiveness. ObjectiveThis study aims to assess the feasibility, acceptability, and potential impact of a novel mHealth app for smokers who want to quit smoking someday but are ambivalent about quitting in the near term. MethodsWe enrolled adults across the United States who smoked more than 10 cigarettes a day and were ambivalent about quitting (n=60). Participants were randomly assigned to 1 of 2 versions of the GEMS app: standard care (SC) versus enhanced care (EC). Both had a similar design and identical evidence-based, best-practice smoking cessation advice and resources, including the ability to earn free nicotine patches. EC also included a series of exercises called experiments designed to help ambivalent smokers clarify their goals, strengthen their motivation, and learn important behavioral skills for changing smoking behavior without making a commitment to quit. Outcomes were analyzed using automated app data and self-reported surveys at 1 and 3 months post enrollment. ResultsParticipants who installed the app (57/60, 95%) were largely female, White, socioeconomically disadvantaged, and highly nicotine dependent. As expected, key outcomes trended in favor of the EC group. Compared to SC users, EC participants had greater engagement (mean sessions 19.9 for EC vs 7.3 for SC). An intentional quit attempt was reported by 39.3% (11/28) of EC users and 37.9% (11/29) of SC users. Seven-day point prevalence smoking abstinence at the 3-month follow-up was reported by 14.7% (4/28) of EC users and 6.9% (2/29) of SC users. Among participants who earned a free trial of nicotine replacement therapy based on their app usage, 36.4% (8/22) of EC participants and 11.1% (2/18) of SC participants requested the treatment. A total of 17.9% (5/28) of EC and 3.4% (1/29) of SC participants used an in-app feature to access a free tobacco quitline. Other metrics were also promising. EC participants completed an average of 6.9 (SD 3.1) out of 9 experiments. Median helpfulness ratings for completed experiments ranged from 3 to 4 on a 5-point scale. Finally, satisfaction with both app versions was very good (mean 4.1 on a 5-point Likert scale) and 95.3% (41/43) of all respondents would recommend their app version to others. ConclusionsAmbivalent smokers were receptive to the app-based intervention, but the EC version, which combined best-practice cessation advice with self-paced, experiential exercises, was associated with greater use and evidence of behavior change. Further development and evaluation of the EC program is warranted. Trial RegistrationClinicalTrials.gov NCT04560868; https://clinicaltrials.gov/ct2/show/NCT04560868
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- 2023
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10. Investigating Past Livestock Mobility Using δ34S Stable Isotopes: Three Preliminary Case Studies From Prehistoric Croatia
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E. Zavodny, S. B. McClure, B. J. Culleton, E. Podrug, J. Balen, I. Drnić, and D. J. Kennett
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sulfur ,stable isotopes ,zooarchaeology ,transhumance ,croatia ,Human evolution ,GN281-289 ,Prehistoric archaeology ,GN700-890 ,Paleontology ,QE701-760 - Abstract
The benefit of including sulfur (δ34S) stable isotopes in studies of past human diet and migration is increasingly clear, but δ34S analyses remain underutilized in addressing other patterns of mobility, animal management, and environmental change in the archaeological record. Here we evaluate the ability of δ34S isotope values to act as proxies for prehistoric environments in three distinct regions of Croatia: northern Dalmatia, Lika, and central Croatia. We then assess if δ34S isotope values can highlight differences in herding and management practices of livestock in these areas, specifically those that encourage the movement of herds into various parts of the landscape (e.g., transhumance vs. localized grazing). Analysis of faunal stable isotope values from these geographically diverse sites constitute the first step in building an environmental database for Croatia and addressing questions of how δ34S can be applied to questions about animal husbandry in the archaeological record.
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- 2022
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11. Comprehensive Analysis of the Immunogenomics of Triple-Negative Breast Cancer Brain Metastases From LCCC1419
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Eric D. Routh, Amanda E. D. Van Swearingen, Maria J. Sambade, Steven Vensko, Marni B. McClure, Mark G. Woodcock, Shengjie Chai, Luz A. Cuaboy, Amy Wheless, Amy Garrett, Lisa A. Carey, Alan P. Hoyle, Joel S. Parker, Benjamin G. Vincent, and Carey K. Anders
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triple-negative breast cancer ,brain metastases ,immunogenomics ,whole-exome sequencing ,mRNA sequencing ,biobank ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundTriple negative breast cancer (TNBC) is an aggressive variant of breast cancer that lacks the expression of estrogen and progesterone receptors (ER and PR) and HER2. Nearly 50% of patients with advanced TNBC will develop brain metastases (BrM), commonly with progressive extracranial disease. Immunotherapy has shown promise in the treatment of advanced TNBC; however, the immune contexture of BrM remains largely unknown. We conducted a comprehensive analysis of TNBC BrM and matched primary tumors to characterize the genomic and immune landscape of TNBC BrM to inform the development of immunotherapy strategies in this aggressive disease.MethodsWhole-exome sequencing (WES) and RNA sequencing were conducted on formalin-fixed, paraffin-embedded samples of BrM and primary tumors of patients with clinical TNBC (n = 25, n = 9 matched pairs) from the LCCC1419 biobank at UNC—Chapel Hill. Matched blood was analyzed by DNA sequencing as a comparison for tumor WES for the identification of somatic variants. A comprehensive genomics assessment, including mutational and copy number alteration analyses, neoantigen prediction, and transcriptomic analysis of the tumor immune microenvironment were performed.ResultsPrimary and BrM tissues were confirmed as TNBC (23/25 primaries, 16/17 BrM) by immunohistochemistry and of the basal intrinsic subtype (13/15 primaries and 16/19 BrM) by PAM50. Compared to primary tumors, BrM demonstrated a higher tumor mutational burden. TP53 was the most frequently mutated gene and was altered in 50% of the samples. Neoantigen prediction showed elevated cancer testis antigen- and endogenous retrovirus-derived MHC class I-binding peptides in both primary tumors and BrM and predicted that single-nucleotide variant (SNV)-derived peptides were significantly higher in BrM. BrM demonstrated a reduced immune gene signature expression, although a signature associated with fibroblast-associated wound healing was elevated in BrM. Metrics of T and B cell receptor diversity were also reduced in BrM.ConclusionsBrM harbored higher mutational burden and SNV-derived neoantigen expression along with reduced immune gene signature expression relative to primary TNBC. Immune signatures correlated with improved survival, including T cell signatures. Further research will expand these findings to other breast cancer subtypes in the same biobank. Exploration of immunomodulatory approaches including vaccine applications and immune checkpoint inhibition to enhance anti-tumor immunity in TNBC BrM is warranted.
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- 2022
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12. MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis
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Othello Del Rosario, Karthik Suresh, Medha Kallem, Gayatri Singh, Anika Shah, Linda Zheng, Xin Yun, Nicolas M. Philip, Nirupama Putcha, Marni B. McClure, Haiyang Jiang, Franco D’Alessio, Meera Srivastava, Alakesh Bera, Larissa A. Shimoda, Michael Merchant, Madhavi J. Rane, Carolyn E. Machamer, Jason Mock, Robert Hagan, Abigail L. Koch, Naresh M. Punjabi, Todd M. Kolb, and Mahendra Damarla
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Pulmonary and Respiratory Medicine ,Physiology ,Physiology (medical) ,Cell Biology - Abstract
We have previously identified mitogen-activated protein kinase-activated protein kinase 2 (MK2) is required for caspase-3 nuclear translocation in the execution of apoptosis; however, little is known of the underlying mechanisms. Therefore, we sought to determine the role of kinase and nonkinase functions of MK2 in promoting nuclear translocation of caspase-3. We identified two non-small cell lung cancer cell lines for use in these experiments based on low MK2 expression. Wild-type, enzymatic and cellular localization mutant MK2 constructs were expressed using adenoviral infection. Cell death was evaluated by flow cytometry. In addition, cell lysates were harvested for protein analyses. Phosphorylation of caspase-3 was determined using two-dimensional gel electrophoresis followed by immunoblotting and in vitro kinase assay. Association between MK2 and caspase-3 was evaluated using proximity-based biotin ligation assays and co-immunoprecipitation. Overexpression of MK2 resulted in nuclear translocation of caspase-3 and caspase-3-mediated apoptosis. MK2 directly phosphorylates caspase-3; however, phosphorylation status of caspase-3 or MK2-dependent phosphorylation of caspase-3 did not alter caspase-3 activity. The enzymatic function of MK2 was dispensable in nuclear translocation of caspase-3. MK2 and caspase-3 associated together and a nonenzymatic function of MK2, chaperoned nuclear trafficking, is required for caspase-3-mediated apoptosis. Taken together, our results demonstrate a nonenzymatic role for MK2 in the nuclear translocation of caspase-3. Furthermore, MK2 may function as a molecular switch in regulating the transition between the cytosolic and nuclear functions of caspase-3.
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- 2023
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13. Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer
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Karthik Suresh, Othello Del Rosario, Medha Kallem, Gayatri Singh, Anika Shah, Linda Zheng, Xin Yun, Nicolas M. Philip, Nirupama Putcha, Marni B. McClure, Haiyang Jiang, Franco D’Alessio, Meera Srivastava, Alakesh Bera, Larissa A. Shimoda, Michael Merchant, Madhavi J. Rane, Carolyn E. Machamer, Jason Mock, Robert Hagan, Abigail L. Koch, Naresh M. Punjabi, Todd M. Kolb, and Mahendra Damarla
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Physiology ,Genetics - Abstract
MK2, known to promote caspase-3 nuclear translocation in the execution of apoptosis, is reduced in non-small cell lung cancer cells. In adenocarcinomas of patients, higher MK2 expression is associated with early-stage disease, better clinical response following chemotherapy and independently associated with improved survival.
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- 2023
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14. 'They're Going to Zoom It': A Qualitative Investigation of Impacts and Coping Strategies During the COVID-19 Pandemic Among Older Adults
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Mikael Anne Greenwood-Hickman, Jacklyn Dahlquist, Julie Cooper, Erika Holden, Jennifer B. McClure, Kayne D. Mettert, Stephen R. Perry, and Dori E. Rosenberg
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aging ,social isolation ,stress ,physical activity ,sedentary behavior ,Public aspects of medicine ,RA1-1270 - Abstract
Introduction: Older adults, who already have higher levels of social isolation, loneliness, and sedentary behavior, are particularly susceptible to negative impacts from social distancing mandates meant to control the spread of COVID-19. We sought to explore the physical, mental, and social health impacts of the pandemic on older adults and their coping techniques.Materials and Methods: We conducted 25 semi-structured interviews with a sub-sample of participants in an ongoing sedentary behavior reduction intervention. Interviews were recorded and transcribed, and iterative coding was used to extract key themes.Results: Most participants reported an increase in sedentary behavior due to limitations on leaving their home and increased free time to pursue seated hobbies (e.g., reading, knitting, tv). However, many participants also reported increased levels of intentional physical activity and exercise, particularly outdoors or online. Participants also reported high levels of stress and a large decrease in in-person social connection. Virtual connection with others through phone and video was commonly used to stay connected with friends and family, engage in community groups and activities, and cope with stress and social isolation. Maintenance of a positive attitude and perspective gained from past hardships was also an important coping strategy for many participants.Discussion: The COVID-19 pandemic and associated social distancing measures have impacted older adults' perceived levels of activity, stress, and social isolation, but many leveraged technology and prior life experiences to cope. These themes could inform future interventions for older adults dealing with chronic stress and isolation.
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- 2021
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15. Point‐of‐care ultrasound diagnosis of a pyogenic liver abscess in the emergency department
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Matthew B. McClure, Kishan Patel, Gabriel Cabrera, and Eric J. Kalivoda
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emergency department ,emergency ultrasound ,hepatic abscess ,point‐of‐care ultrasound ,pyogenic liver abscess ,ultrasonography ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Pyogenic liver abscess (PLA) is a rarely encountered condition in the emergency department (ED) that necessitates a timely diagnosis by the emergency physician. An early ED diagnosis is challenging as the presenting symptoms of PLA are often variable and nonspecific. The rapid bedside diagnosis of PLA with point‐of‐care ultrasound (POCUS) performed by emergency physicians has not been investigated thoroughly. This case report describes the expeditious identification and ED management of PLA by implementing emergency physician‐performed POCUS as the initial diagnostic modality.
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- 2021
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16. Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer RevealsTP53Aneuploidy–driven Metabolic Reprogramming
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Marni B. McClure, Yasunori Kogure, Naser Ansari-Pour, Yuki Saito, Hann-Hsiang Chao, Jonathan Shepherd, Mariko Tabata, Olufunmilayo I. Olopade, David C. Wedge, Katherine A. Hoadley, Charles M. Perou, and Keisuke Kataoka
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The hallmark signatures based on gene expression capture core cancer processes. Through a pan-cancer analysis, we describe the overview of hallmark signatures across tumor types/subtypes and reveal significant relationships between these signatures and genetic alterations. TP53 mutation exerts diverse changes, including increased proliferation and glycolysis, which are closely mimicked by widespread copy-number alterations. Hallmark signature and copy-number clustering identify a cluster of squamous tumors and basal-like breast and bladder cancers with elevated proliferation signatures, frequent TP53 mutation, and high aneuploidy. In these basal-like/squamous TP53-mutated tumors, a specific and consistent spectrum of copy-number alterations is preferentially selected prior to whole-genome duplication. Within Trp53-null breast cancer mouse models, these copy-number alterations spontaneously occur and recapitulate the hallmark signature changes observed in the human condition. Together, our analysis reveals intertumor and intratumor heterogeneity of the hallmark signatures, uncovering an oncogenic program induced by TP53 mutation and select aneuploidy events to drive a worsened prognosis.Significance:Our data demonstrate that TP53 mutation and a resultant selected pattern of aneuploidies cause an aggressive transcriptional program including upregulation of glycolysis signature with prognostic implications. Importantly, basal-like breast cancer demonstrates genetic and/or phenotypic changes closely related to squamous tumors including 5q deletion that reveal alterations that could offer therapeutic options across tumor types regardless of tissue of origin.
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- 2023
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17. A pedagogical approach to science outreach.
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Marni B McClure, Kacey C Hall, Erin F Brooks, Catherine T Allen, and Kenneth S Lyle
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Biology (General) ,QH301-705.5 - Abstract
Encouragement of students across all communities through scientific outreach programs is critical to engaging the next generation, exciting young minds to pursue careers in science and medicine. Herein, we present a uniquely structured and widely influential science outreach program. Founded in 2005, the Duke Chemistry Outreach (DCO) employs a pedagogical approach to outreach that aims to teach its audience a new scientific concept, while instilling a pure enjoyment of science. DCO has performed 583 events reaching over 70,000 participants throughout 2,270 hours, with the majority of events in Durham, the surrounding North Carolinian communities, and across 8 other states. The flexibility and diversity of this outreach program creates a framework amendable for others to adopt in both secondary and higher education settings.
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- 2020
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18. Factors associated with future dental care utilization among low-income smokers overdue for dental visits
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Paula R. Blasi, Chloe Krakauer, Melissa L. Anderson, Jennifer Nelson, Terry Bush, Sheryl L. Catz, and Jennifer B. McClure
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Oral health ,Oral health care ,Dental care ,Smoking ,Tobacco ,Dental insurance ,Dentistry ,RK1-715 - Abstract
Abstract Background Smokers are at increased risk of oral disease. While routine dental care can help prevent and treat oral health problems, smokers have far lower rates of dental care utilization compared with non-smokers. We sought to better understand which factors may facilitate or hinder dental care utilization among low-income smokers participating in a randomized intervention trial in order to inform future intervention planning. Methods This is a secondary analysis of data collected between 2015 and 2017 as part of the OralHealth4Life trial. Participants were eligible callers to the Louisiana, Nebraska, and Oregon state tobacco quitlines who had no dental appointment in the prior or upcoming six months. We examined the association between participants’ baseline characteristics and their receiving professional dental care between baseline and the 6-month follow-up survey. Results Participants were racially diverse (42% non-White) and two-thirds had an annual household income under $20,000. Most (86.7%) had not had a dental cleaning in more than one year. Commonly cited barriers to dental care included cost (83.7%) and no dental insurance (78.1%). Those with dental insurance were more likely to see a dentist at follow-up (RR 1.66). Similarly, those reporting a dental insurance barrier to care were less likely to see a dentist at follow-up (RR 0.69); however, there was no significant utilization difference between those reporting a cost barrier vs. those who did not. After controlling for these financial factors, the following baseline characteristics were significantly associated with a higher likelihood of dental care utilization at 6 months: higher motivation (RR 2.16) and self-efficacy (RR 1.80) to visit the dentist, having a disability (RR 1.63), having a higher education level (RR 1.52), and having perceived gum disease (RR 1.49). Factors significantly associated with a lower likelihood of dental care utilization included being married (RR 0.68) and not having a last dental cleaning within the past year (RR 0.47). Conclusions Our findings provide important insight into factors that may facilitate or deter use of professional dental care among low-income smokers. This information could inform the development of future interventions to promote dental care utilization. Trial registration ClinicalTrials.gov: NCT02347124; registered 27 January 2015.
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- 2018
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19. The Zooarchaeology of Neolithic farmers: Herding and hunting on the Dalmatian coast of Croatia
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Sarah B. McClure, Emil Podrug, Jelena Jović, Shayla Monroe, Hugh D. Radde, Nicholas Triozzi, Martin H. Welker, and Emily Zavodny
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Earth-Surface Processes - Published
- 2022
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20. Determination of Autogenous Ignition Temperature for Isopropyl Alcohol and Ethanol
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Daniel J Dorney, Susana A Harper, Mark B Mcclure, Ilse A Reyes, Daniel J Wentzel, and Alfredo Juarez
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Spacecraft Propulsion And Power - Abstract
As part of a recent liquid rocket engine shutdown investigation, a commercial partner requested that NASA provide the autogenous ignition (or autoignition) temperature (AIT) of isopropyl alcohol (IPA). NASA provided the available data, but the data were somewhat scattered, likely due to test configuration and test technique differences. NASA Engineering and Safety Center (NESC) support was requested to experimentally determine the AIT of IPA and ethanol, both of which are extensively applied to propulsion systems. This report contains the outcome of the NESC assessment.
- Published
- 2020
21. Shared Calendars for Home Health Management.
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Jordan Eschler, Logan Kendall, Kathleen O'Leary, Lisa M. Vizer, Paula Lozano, Jennifer B. McClure, Wanda Pratt, and James D. Ralston
- Published
- 2015
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22. Table S7 from Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1
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Keisuke Kataoka, Kazuya Shimoda, Seishi Ogawa, Yosuke Togashi, Atae Utsunomiya, Nobuaki Nakano, Akira Kitanaka, Tomonori Hidaka, Yoko Kubuki, Kotaro Shide, Masaaki Sekine, Ayako Kamiunten, Keiichi Akizuki, Yuki Tahira, Mariko Tabata, Sumito Shingaki, Marni B. McClure, Joji Nagasaki, Mitsuhiro Yuasa, Yasunori Kogure, Takuro Kameda, Yuki Saito, and Junji Koya
- Abstract
Candidate pathogenic mutations detected by WES or targeted-seq in ATL and AC samples
- Published
- 2023
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- View/download PDF
23. Supplementary Data from Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1
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Keisuke Kataoka, Kazuya Shimoda, Seishi Ogawa, Yosuke Togashi, Atae Utsunomiya, Nobuaki Nakano, Akira Kitanaka, Tomonori Hidaka, Yoko Kubuki, Kotaro Shide, Masaaki Sekine, Ayako Kamiunten, Keiichi Akizuki, Yuki Tahira, Mariko Tabata, Sumito Shingaki, Marni B. McClure, Joji Nagasaki, Mitsuhiro Yuasa, Yasunori Kogure, Takuro Kameda, Yuki Saito, and Junji Koya
- Abstract
Supplementary methods, Supplementary Figures, Supplementary Figure Legends, Supplementary Table Legends, Supplementary references, and Key resource table.
- Published
- 2023
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- View/download PDF
24. Data from Single-Cell Analysis of the Multicellular Ecosystem in Viral Carcinogenesis by HTLV-1
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Keisuke Kataoka, Kazuya Shimoda, Seishi Ogawa, Yosuke Togashi, Atae Utsunomiya, Nobuaki Nakano, Akira Kitanaka, Tomonori Hidaka, Yoko Kubuki, Kotaro Shide, Masaaki Sekine, Ayako Kamiunten, Keiichi Akizuki, Yuki Tahira, Mariko Tabata, Sumito Shingaki, Marni B. McClure, Joji Nagasaki, Mitsuhiro Yuasa, Yasunori Kogure, Takuro Kameda, Yuki Saito, and Junji Koya
- Abstract
Premalignant clonal expansion of human T-cell leukemia virus type-1 (HTLV-1)–infected cells occurs before viral carcinogenesis. Here we characterize premalignant cells and the multicellular ecosystem in HTLV-1 infection with and without adult T-cell leukemia/lymphoma (ATL) by genome sequencing and single-cell simultaneous transcriptome and T/B-cell receptor sequencing with surface protein analysis. We distinguish malignant phenotypes caused by HTLV-1 infection and leukemogenesis and dissect clonal evolution of malignant cells with different clinical behavior. Within HTLV-1–infected cells, a regulatory T-cell phenotype associates with premalignant clonal expansion. We also delineate differences between virus- and tumor-related changes in the nonmalignant hematopoietic pool, including tumor-specific myeloid propagation. In a newly generated conditional knockout mouse model recapitulating T-cell–restricted CD274 (encoding PD-L1) gene lesions found in ATL, we demonstrate that PD-L1 overexpressed by T cells is transferred to surrounding cells, leading to their PD-L1 upregulation. Our findings provide insights into clonal evolution and immune landscape of multistep virus carcinogenesis.Significance:Our multimodal single-cell analyses comprehensively dissect the cellular and molecular alterations of the peripheral blood in HTLV-1 infection, with and without progression to leukemia. This study not only sheds light on premalignant clonal expansion in viral carcinogenesis, but also helps to devise novel diagnostic and therapeutic strategies for HTLV-1–related disorders.This article is highlighted in the In This Issue feature, p. 403
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- 2023
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25. Clinic, Home, and Kiosk Blood Pressure Measurements for Diagnosing Hypertension: a Randomized Diagnostic Study
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Beverly B Green, Melissa L Anderson, Andrea J Cook, Kelly Ehrlich, Yoshio N Hall, Clarissa Hsu, Dwayne Joseph, Predrag Klasnja, Karen L Margolis, Jennifer B McClure, Sean A Munson, and Mathew J Thompson
- Subjects
Hypertension ,Internal Medicine ,Humans ,Blood Pressure ,Blood Pressure Determination ,Blood Pressure Monitoring, Ambulatory ,Middle Aged ,Antihypertensive Agents - Abstract
Background The US Preventive Services Task Force recommends blood pressure (BP) measurements using 24-h ambulatory monitoring (ABPM) or home BP monitoring before making a new hypertension diagnosis. Objective Compare clinic-, home-, and kiosk-based BP measurement to ABPM for diagnosing hypertension. Design, Setting, and Participants Diagnostic study in 12 Washington State primary care centers, with participants aged 18–85 years without diagnosed hypertension or prescribed antihypertensive medications, with elevated BP in clinic. Interventions Randomization into one of three diagnostic regimens: (1) clinic (usual care follow-up BPs); (2) home (duplicate BPs twice daily for 5 days); or (3) kiosk (triplicate BPs on 3 days). All participants completed ABPM at 3 weeks. Main Measures Primary outcome was difference between ABPM daytime and clinic, home, and kiosk mean systolic BP. Differences in diastolic BP, sensitivity, and specificity were secondary outcomes. Key Results Five hundred ten participants (mean age 58.7 years, 80.2% white) with 434 (85.1%) included in primary analyses. Compared to daytime ABPM, adjusted mean differences in systolic BP were clinic (−4.7mmHg [95% confidence interval −7.3, −2.2]; PP=.92); and kiosk (9.5mmHg [7.5, 11.6];PPP=.52); and kiosk (5.0mmHg [3.8, 6.2]; P Limitations Single health care organization and limited race/ethnicity representation. Conclusions Compared to ABPM, mean BP was significantly lower for clinic, significantly higher for kiosk, and without significant differences for home. Clinic BP measurements had low sensitivity for detecting hypertension. Findings support utility of home BP monitoring for making a new diagnosis of hypertension. Trial Registration ClinicalTrials.gov NCT03130257 https://clinicaltrials.gov/ct2/show/NCT03130257
- Published
- 2022
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26. Whole-genome landscape of adult T-cell leukemia/lymphoma
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Yoko Kubuki, Kengo Takeuchi, Seishi Ogawa, Yuki Tahira, Akifumi Takaori-Kondo, Kota Yoshifuji, Makoto Yoshimitsu, Kenichi Chiba, Masaaki Sekine, Ai Okada, Ana Acuna-Villaorduna, Yuichi Shiraishi, Yasushi Miyazaki, Tatsuhiro Shibata, Jun-ichirou Yasunaga, Tomonori Hidaka, Michihiro Hidaka, Mariko Tabata, Kisato Nosaka, Masao Matsuoka, Yasunori Kogure, Takuro Kameda, R. Alejandro Sica, Yuta Ito, B. Hilda Ye, Yoshitaka Imaizumi, Ayako Kamiunten, Sumito Shingaki, Keiichi Akizuki, Yuki Saito, Juan Carlos Ramos, Kazuya Shimoda, Junji Koya, Murali Janakiram, Marni B McClure, Urvi A Shah, Yasuhito Nannya, Kenji Ishitsuka, Mizuki Watanabe, Nobuaki Nakano, Satoru Miyano, Nobuyuki Kakiuchi, Atae Utsunomiya, Keisuke Kataoka, Kotaro Shide, and Akira Kitanaka
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DNA Copy Number Variations ,Immunology ,Somatic hypermutation ,Biology ,Biochemistry ,Genome ,Adult T-cell leukemia/lymphoma ,Mice ,Exome Sequencing ,Biomarkers, Tumor ,medicine ,Animals ,Humans ,Leukemia-Lymphoma, Adult T-Cell ,IL-2 receptor ,Gene ,Ataxin-1 ,Genetics ,Genome, Human ,Germinal center ,FOXP3 ,Cell Biology ,Hematology ,Prognosis ,medicine.disease ,Proto-Oncogene Proteins c-rel ,Gene Expression Regulation, Neoplastic ,Mice, Inbred C57BL ,Repressor Proteins ,Survival Rate ,Leukemia ,Mutation ,Female - Abstract
Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasm immunophenotypically resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we performed whole-genome sequencing (WGS) of 150 ATL cases to reveal the overarching landscape of genetic alterations in ATL. We discovered frequent (33%) loss-of-function alterations preferentially targeting the CIC long isoform, which were overlooked by previous exome-centric studies of various cancer types. Long but not short isoform–specific inactivation of Cic selectively increased CD4+CD25+Foxp3+ T cells in vivo. We also found recurrent (13%) 3′-truncations of REL, which induce transcriptional upregulation and generate gain-of-function proteins. More importantly, REL truncations are also common in diffuse large B-cell lymphoma, especially in germinal center B-cell–like subtype (12%). In the non-coding genome, we identified recurrent mutations in regulatory elements, particularly splice sites, of several driver genes. In addition, we characterized the different mutational processes operative in clustered hypermutation sites within and outside immunoglobulin/T-cell receptor genes and identified the mutational enrichment at the binding sites of host and viral transcription factors, suggesting their activities in ATL. By combining the analyses for coding and noncoding mutations, structural variations, and copy number alterations, we discovered 56 recurrently altered driver genes, including 11 novel ones. Finally, ATL cases were classified into 2 molecular groups with distinct clinical and genetic characteristics based on the driver alteration profile. Our findings not only help to improve diagnostic and therapeutic strategies in ATL, but also provide insights into T-cell biology and have implications for genome-wide cancer driver discovery.
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- 2022
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27. Pastoralism, hunting, and coexistence: Domesticated and wild bovids in Neolithic Sudan
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Shayla Monroe, Stuart Tyson Smith, and Sarah B. McClure
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Archeology ,Anthropology - Published
- 2023
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28. Acceptability and Adherence to Home, Kiosk, and Clinic Blood Pressure Measurement Compared to 24-H Ambulatory Monitoring
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Matthew J. Thompson, Melissa L. Anderson, Andrea J. Cook, Kelly Ehrlich, Yoshio N. Hall, Clarissa Hsu, Karen L. Margolis, Jennifer B. McClure, Sean A. Munson, and Beverly B. Green
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Internal Medicine - Published
- 2023
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29. Integrating the patient portal into the health management work ecosystem: user acceptance of a novel prototype.
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Jordan Eschler, Perry Lin Meas, Paula Lozano, Jennifer B. McClure, James D. Ralston, and Wanda Pratt
- Published
- 2016
30. Persuasive Reminders for Health Self-Management.
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Katie O'Leary, Leslie S. Liu 0001, Jennifer B. McClure, James D. Ralston, and Wanda Pratt
- Published
- 2016
31. Estimating heat tolerance of buds in southeastern US trees in fire-prone forests
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Adam B. McClure, T. Adam Coates, J. Kevin Hiers, John R. Seiler, Joseph J. O’Brien, and Chad M. Hoffman
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Forestry ,Environmental Science (miscellaneous) ,Ecology, Evolution, Behavior and Systematics - Abstract
Background Traits of mature trees, such as bark thickness and texture, have been documented to promote resistance or resilience to heating in fire-prone forests. These traits often assist managers as they plan and promote prescribed fire management to accomplish specific land management objectives. Species are often grouped together as pyrophobes or pyrophytes as a result of these features. Nonetheless, little is known about species-specific traits of other structures, such as bud diameter, length, mass, moisture content, and surface area, that might be related to heat tolerance. Many prescribed fires are utilized in the eastern United States to control regeneration of less desired species, which could apply a more mechanistic understanding of energy doses that result in topkilling mid-story stems. In this study, we investigated potential relationships between terminal bud mortality from lateral branches of midstory stems and species-specific bud features of six eastern US deciduous trees. Characterized at maturity as either pyrophytes or pyrophobes, each was exposed to different heat dosages in a laboratory setting. Results Bud diameter, length, mass, moisture content, and surface area differed by species. Bud percent mortality at the first heat flux density (0.255–0.891MJm−2) was highest for two pyrophobes, chestnut oak (Quercus montana Willd.) and scarlet oak (Quercus coccinea Münchh). For the second heat flux density (1.275–1.485MJm−2), bud percent mortality was highest for these species and red maple (Acer rubrum L.). Principal component analysis suggested that bud surface area and length differentiated species. Red maple, chestnut oak, and scarlet oak produced clusters of buds, which may explain their more pronounced bud mortality. Yellow-poplar (Liriodendron tulipifera L.) was also present in that cluster, suggesting that its unique bud architecture of pre-emergent leaves may have elicited responses most similar to those of the clustered buds. Conclusions Contrary to expectations, lateral buds of species regarded as pyrophytes at maturity displayed some of the highest values of bud percent mortality when heated at two heat flux densities generated in a laboratory. Their responses may be related to clustering of their lateral buds. Testing of additional species using these methods in a laboratory setting, and perhaps additional methodologies in the field, is warranted.
- Published
- 2022
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32. Designing Asynchronous Communication Tools for Optimization of Patient-Clinician Coordination.
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Jordan Eschler, Leslie S. Liu 0001, Lisa M. Vizer, Jennifer B. McClure, Paula Lozano, Wanda Pratt, and James D. Ralston
- Published
- 2015
33. Abstract P242: Psychological Distress Related To Hypertension Diagnostic Testing And Diagnosis
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Beverly B Green, Melissa L Anderson, Karen L Margolis, and Jennifer B McClure
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Internal Medicine - Abstract
Background: Little information is available as to whether undergoing hypertension diagnostic testing or receiving a new diagnosis of hypertension leads to psychological distress. Design, Setting, and Participants: BP CHECK was a randomized diagnostic study of 510 adults aged 18-85. Participants had elevated BP in clinic at baseline but no previously diagnosed hypertension. The trial was conducted from 2017 to 2019 in primary care centers of an integrated healthcare system. Participants were randomized to one of three diagnostic regimens: (1) Clinic BP, (2) Home BP, or (3) Kiosk BP. All participants completed 24-hour ambulatory blood pressure monitoring (ABPM) at 3 weeks. ABPM results were sent to participants and their primary care providers and uploaded into the electronic health record. This analysis includes a subset of participants (n=255) who completed psychological distress questionnaires at baseline, and at least one follow-up (after completing their diagnostic regimen and 6 months after randomization) Main Outcomes and Measures: The primary outcomes were within-person change in psychological distress (impact of events and state anxiety scales, BP worry Likert 5-point scale) comparing baseline to 3 weeks and 6 months post-enrollment. Results: Participants were half female (127/255), mostly > age 50 (78%), and White race (83%). Baseline mean BP was 150 mmHg systolic and 80 mmHg diastolic; 63.9% had hypertension on ABPM (daytime average > 135/85 mmHg). There was no significant change in impact of events or state anxiety at either follow-up. BP worry was significantly increased at 3 weeks (mean change 0.22 (0.13-0.30), but not at 6 months. Six month outcomes were not influenced by ABPM test results or receiving a hypertension diagnosis. Conclusion and Relevance: The hypertension diagnostic process increased hypertension worry short term, but not longer-term. It had little impact on other measures of psychologic distress. The risk of psychologic distress after hypertension diagnostic testing and receipt of a hypertension diagnosis appears to be low, reinforcing the importance of timely hypertension diagnoses. Additional studies with more diverse patient populations are needed.
- Published
- 2022
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34. Tumor-promoting function and regulatory landscape of PD-L2 in B-cell lymphoma
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Sumito Shingaki, Junji Koya, Mitsuhiro Yuasa, Yuki Saito, Mariko Tabata, Marni B. McClure, Seishi Ogawa, Kotoe Katayama, Yosuke Togashi, Seiya Imoto, Yasunori Kogure, and Keisuke Kataoka
- Subjects
Cancer Research ,Oncology ,Hematology - Published
- 2022
35. Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis
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Susana, Garcia-Recio, Toshinori, Hinoue, Gregory L, Wheeler, Benjamin J, Kelly, Ana C, Garrido-Castro, Tomas, Pascual, Aguirre A, De Cubas, Youli, Xia, Brooke M, Felsheim, Marni B, McClure, Andrei, Rajkovic, Ezgi, Karaesmen, Markia A, Smith, Cheng, Fan, Paula I Gonzalez, Ericsson, Melinda E, Sanders, Chad J, Creighton, Jay, Bowen, Kristen, Leraas, Robyn T, Burns, Sara, Coppens, Amy, Wheless, Salma, Rezk, Amy L, Garrett, Joel S, Parker, Kelly K, Foy, Hui, Shen, Ben H, Park, Ian, Krop, Carey, Anders, Julie, Gastier-Foster, Mothaffar F, Rimawi, Rita, Nanda, Nancy U, Lin, Claudine, Isaacs, P Kelly, Marcom, Anna Maria, Storniolo, Fergus J, Couch, Uma, Chandran, Michael, Davis, Jonathan, Silverstein, Alexander, Ropelewski, Minetta C, Liu, Susan G, Hilsenbeck, Larry, Norton, Andrea L, Richardson, W Fraser, Symmans, Antonio C, Wolff, Nancy E, Davidson, Lisa A, Carey, Adrian V, Lee, Justin M, Balko, Katherine A, Hoadley, Peter W, Laird, Elaine R, Mardis, and Tari A, King
- Abstract
The AURORA US Metastasis Project was established with the goal to identify molecular features associated with metastasis. We assayed 55 females with metastatic breast cancer (51 primary cancers and 102 metastases) by RNA sequencing, tumor/germline DNA exome and low-pass whole-genome sequencing and global DNA methylation microarrays. Expression subtype changes were observed in ~30% of samples and were coincident with DNA clonality shifts, especially involving HER2. Downregulation of estrogen receptor (ER)-mediated cell-cell adhesion genes through DNA methylation mechanisms was observed in metastases. Microenvironment differences varied according to tumor subtype; the ER
- Published
- 2022
36. Analysis of stratigraphical sequences at Cocina Cave (Spain) using rare earth elements geochemistry
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Alfredo Cortell-Nicolau, Gianni Gallello, Agustín Pastor, Agustin Diez-Castillo, Oreto García-Puchol, Simon Chenery, Maria Luisa Cervera, Sarah B. McClure, and Mirco Ramacciotti
- Subjects
010506 paleontology ,Archeology ,geography ,geography.geographical_feature_category ,060102 archaeology ,Rare earth ,Geochemistry ,Geology ,06 humanities and the arts ,15. Life on land ,01 natural sciences ,humanities ,Cave ,0601 history and archaeology ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences - Abstract
This study investigates the stratigraphical sequence of Cocina Cave (Spain) employing and testing for the first time the capability of rare earth elements as markers of human activities in caves. Located in Dos Aguas (Valencian Community, Spain), Cocina Cave is characterized by the presence of several Holocene archaeological deposits from the final Mesolithic to the present day and is a pivotal site for understanding the socio‐ecological dynamics of the last hunter‐gatherer inhabitants of the Iberian Peninsula and the transition to pastoral and agricultural economies in the Western Mediterranean. However, the identification of strata from particular time‐periods in the cave is often difficult due to the homogeneity of layers, the poor archaeological record in some strata and the presence of severe disturbance phenomena. The methodological approach of this study consisted of cross‐referencing rare earth elements and other chemical markers with the archaeological stratigraphical interpretation, in an attempt to not only support the identification of the anthropic contribution to the formation of Cocina Cave strata, but also to characterize and confirm different natural and occupational episodes, particularly those associated with hunter‐gatherer, early agriculturalist, and shepherd activities. Sediments were collected from different excavation areas and analysed for major elements, trace elements, rare earth elements (REE), soil organic matter (SOM) amounts and pH. Multivariate statistics were employed to group samples according to their elemental profile, and these were then compared to the archaeological temporal interpretation. The obtained results showed that REE amount and fractionation geochemical processes were regulated by carbonates, phosphates and pH. The use of REE as markers was particularly useful as their concentrations and their calculated ratios and anomaly distributions were demonstrated to be highly consistent with the archaeological stratigraphical interpretation.
- Published
- 2021
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37. Functional Communication Training: A Comprehensive Approach to Success for Educators
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Erica B. McClure and Jonathan L. Burt
- Subjects
Clinical Psychology ,Developmental and Educational Psychology ,Education - Abstract
Functional communication training (FCT) is a strategy to address problem behavior for students with various disabilities that is supported by a broad evidence base. Despite this support, multiple factors continue to dissuade educators from utilizing FCT in their classrooms. This article outlines the process of developing and implementing FCT plans through an efficient approach that includes essential components and tools to aid application while also highlighting potential pitfalls for practitioners to avoid.
- Published
- 2023
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38. COVID-19 Challenges Confronted by Smoking Cessation Clinical Trials for People Living With HIV: The Experience of Grantees of the US National Cancer Institute
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Damon J. Vidrine, Sheryl L. Catz, E. Jennifer Edelman, Lauren R. Pacek, Steven L. Bernstein, Rebecca L. Ashare, Robert E. Gross, Elizabeth Lockhart, Brian Hitsman, Robert A. Schnoll, Annette R. Kaufman, Kristina Crothers, Roger Vilardaga, Jennifer B. McClure, Stephanie L. Marhefka, and Patricia A. Cioe
- Subjects
medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,medicine.medical_treatment ,Human immunodeficiency virus (HIV) ,MEDLINE ,HIV Infections ,medicine.disease_cause ,Neoplasms ,medicine ,AcademicSubjects/SOC02541 ,Humans ,SARS-CoV-2 ,business.industry ,Public Health, Environmental and Occupational Health ,COVID-19 ,Cancer ,Biological classification ,medicine.disease ,National Cancer Institute (U.S.) ,United States ,Clinical trial ,Family medicine ,Commentary ,Smoking cessation ,Smoking Cessation ,AcademicSubjects/MED00010 ,business - Published
- 2021
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39. 'I wanna be your dog': Evaluating the efficacy of univariate and multivariate methods for differentiating domestic and wild canids in North America
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Sarah B. McClure, Martin H. Welker, and David A. Byers
- Subjects
Archeology ,Multivariate statistics ,Geography ,Anthropology ,Univariate ,Domestication ,Tooth crowding ,Demography - Published
- 2021
- Full Text
- View/download PDF
40. Engineering for reliability in at-home chronic disease management.
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Logan Kendall, Jordan Eschler, Paula Lozano, Jennifer B. McClure, Lisa M. Vizer, James D. Ralston, and Wanda Pratt
- Published
- 2014
41. Reducing Sitting Time in Obese Older Adults: The I-STAND Randomized Controlled Trial
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Jennifer B. McClure, Mikael Anne Greenwood-Hickman, Dori E. Rosenberg, Amy S. Lee, Theresa E Matson, David Arterburn, Paula Gardiner, Anne Renz, Jacqueline Kerr, and Melissa L. Anderson
- Subjects
medicine.medical_specialty ,business.industry ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,030204 cardiovascular system & hematology ,medicine.disease ,Sitting ,Obesity ,Article ,Sitting time ,Confidence interval ,law.invention ,Fasting glucose ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Randomized controlled trial ,law ,medicine ,Physical therapy ,030212 general & internal medicine ,Geriatrics and Gerontology ,business ,Gerontology ,Body mass index - Abstract
Background: The authors tested the efficacy of the “I-STAND” intervention for reducing sitting time, a novel and potentially health-promoting approach, in older adults with obesity. Methods: The authors recruited 60 people (mean age = 68 ± 4.9 years, 68% female, 86% White; mean body mass index = 35.4). The participants were randomized to receive the I-STAND sitting reduction intervention (n = 29) or healthy living control group (n = 31) for 12 weeks. At baseline and at 12 weeks, the participants wore activPAL devices to assess sitting time (primary outcome). Secondary outcomes included fasting glucose, blood pressure, and weight. Linear regression models assessed between-group differences in the outcomes. Results: The I-STAND participants significantly reduced their sitting time compared with the controls (–58 min per day; 95% confidence interval [–100.3, –15.6]; p = .007). There were no statistically significant changes in the secondary outcomes. Conclusion: I-STAND was efficacious in reducing sitting time, but not in changing health outcomes in older adults with obesity.
- Published
- 2020
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42. Genome wide association study of passive immunity and disease traits in beef-suckler and dairy calves on Irish farms
- Author
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Sinead M. Waters, Mark McGee, Jennifer B. McClure, Dayle Johnston, Bernadette Earley, C.G. Todd, Carla Surlis, Matthew C. McClure, and Robert Mukiibi
- Subjects
0301 basic medicine ,Veterinary medicine ,Genotyping Techniques ,Globulin ,medicine.medical_treatment ,lcsh:Medicine ,Diseases ,Single-nucleotide polymorphism ,Genome-wide association study ,Passive immunity ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,Quantitative Trait, Heritable ,Immunity ,Genetics ,medicine ,Animals ,lcsh:Science ,Genotyping ,Disease Resistance ,Multidisciplinary ,biology ,lcsh:R ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,Heritability ,040201 dairy & animal science ,Animals, Suckling ,030104 developmental biology ,Genetic marker ,Immunoglobulin G ,biology.protein ,Cattle ,Female ,lcsh:Q ,Zoology ,Immunity, Maternally-Acquired ,Ireland ,Biomarkers ,Genome-Wide Association Study - Abstract
Calves with lower concentrations of immunoglobulin G (IgG) in their blood, have a greater risk of developing diseases. There is a lack of knowledge on genetic markers known to be associated with immunological variability or disease resistance. Therefore, the objective of this study was to identify SNP markers associated with passive immunity measures (serum IgG, serum protein, albumin, globulin and total protein concentrations, total solids Brix percentage, zinc sulphate turbidity units) and disease (pneumonia, diarrhoea, crude illness) traits in Irish commercial beef-suckler and dairy calves through genome wide association studies (GWAS). Genotyping was performed on DNA samples from beef-suckler (n = 698) and dairy (n = 1178) calves, using the IDBv3 chip. Heritability of passive immunity associated traits (range 0.02–0.22) and the disease traits (range 0.03–0.20) were low-to-moderate. Twenty-five and fifteen SNPs approached genome wide significance (P −5) for the passive immunity and the disease traits, respectively. One SNP “ARS-BFGL-BAC-27914” reached Bonferroni genome wide significance (P −6) for an association with serum IgG concentration in beef calves. Further work will evaluate these SNPs in larger cattle populations and assess their contribution to genomic selection breeding strategies, aimed towards producing more disease resistant livestock.
- Published
- 2020
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43. The United States National Cancer Institute’s Coordinated Research Effort on Tobacco Use as a Major Cause of Morbidity and Mortality among People with HIV
- Author
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Steven L. Bernstein, E. Jennifer Edelman, Rebecca L. Ashare, Kristina Crothers, Roger Vilardaga, Robert E. Gross, Jennifer B. McClure, Stephanie L. Marhefka, Patricia A. Cioe, Lauren R. Pacek, Brian Hitsman, Damon J. Vidrine, Sheryl L. Catz, Annette R. Kaufman, and Robert A. Schnoll
- Subjects
and promotion of well-being ,medicine.medical_treatment ,Psychological intervention ,HIV Infections ,Tobacco Use ,Substance Misuse ,0302 clinical medicine ,Pandemic ,Medicine ,030212 general & internal medicine ,Cancer ,media_common ,Marketing ,education.field_of_study ,Smoking ,3.5 Resources and infrastructure (prevention) ,Tobacco Use Disorder ,Tobacco Products ,people with HIV ,Infectious Diseases ,Respiratory ,Public Health and Health Services ,HIV/AIDS ,Public Health ,AcademicSubjects/MED00010 ,Infection ,0305 other medical science ,medicine.medical_specialty ,Evidence-based practice ,media_common.quotation_subject ,Clinical Trials and Supportive Activities ,Clinical Sciences ,Population ,03 medical and health sciences ,Clinical Research ,Behavioral and Social Science ,Tobacco ,AcademicSubjects/SOC02541 ,cancer ,Humans ,nicotine dependence ,education ,Pandemics ,Tobacco Use Cessation ,030505 public health ,Tobacco Smoke and Health ,business.industry ,Prevention ,Public Health, Environmental and Occupational Health ,HIV ,COVID-19 ,Abstinence ,Prevention of disease and conditions ,United States ,National Cancer Institute (U.S.) ,Clinical trial ,Good Health and Well Being ,Family medicine ,Commentary ,Life expectancy ,Smoking cessation ,Smoking Cessation ,Morbidity ,business - Abstract
The use of antiretroviral therapy for people with HIV (PWH) has improved life expectancy. However, PWH now lose more life-years to tobacco use than to HIV infection. Unfortunately, PWH smoke at higher rates and have more difficulty maintaining abstinence than the general population, compounding their risk for chronic disease. In this Commentary, we describe a United States National Cancer Institute-led initiative to address the relative lack of research focused on developing, testing, and implementing smoking cessation interventions for PWH. This initiative supports seven clinical trials designed to systematically test and/or develop and test adaptations of evidence-based smoking cessation interventions for PWH (eg, combination of behavioral and pharmacological). We summarize each project, including setting/recruitment sites, inclusion/exclusion criteria, interventions being tested, and outcomes. This initiative provides critical opportunities for collaboration and data harmonization across projects. The knowledge gained will inform strategies to assist PWH to promote and maintain abstinence, and ensure that these efforts are adaptable and scalable, thereby addressing one of the major threats to the health of PWH. Reducing smoking behavior may be particularly important during the COVID-19 pandemic given that smokers who become infected with SARS-CoV-2 may be at risk for more severe disease. Implications This Commentary describes a National Cancer Institute-led initiative to advance the science and practice of treating tobacco use among PWH, which is now responsible for more life years lost than HIV. We describe the scope of the problem, the objectives of the initiative, and a summary of the seven funded studies. Harmonization of data across projects will provide information related to treatment mediators and moderators that was not previously possible. Stakeholders interested in tobacco cessation, including researchers, clinicians and public health officials, should be aware of this initiative and the evidence-base it will generate to advance tobacco treatment among this high-risk population.
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- 2020
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44. Paleodiet and health in a mass burial population: The stable carbon and nitrogen isotopes from Potočani, a 6,200‐year‐old massacre site in Croatia
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Ivor Janković, Hrvoje Potrebica, Sarah B. McClure, Emily Zavodny, Jacqueline Balen, Mario Novak, and Douglas J. Kennett
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Archeology ,education.field_of_study ,Stable isotope ratio ,Population ,chemistry.chemical_element ,Chalcolithic ,Copper Age ,stable isotopes ,mass burial ,Lasinja Culture ,massacre ,Isotopes of nitrogen ,chemistry ,Anthropology ,Environmental chemistry ,Environmental science ,education ,Carbon - Abstract
This paper presents the results of carbon and nitrogen stable isotope analyses on human remains uncovered from Potočani, a Copper Age (Eneolithic) mass burial site in continental Croatia. The remains of at least 41individuals were uncovered in a pit in 2007 during rescue excavations in Požeško‐Slavonska county. Skeletal evidence of violence and the disorganized arrangement of bodies suggest that burial took place over a short period of time. Radiocarbon dates and associated ceramics indicate these people were part of the Lasinja cultural group, dating to the Middle Copper Age (ca.4200 cal BC). Carbon and nitrogen stable isotope analyses on 40individuals indicate higher than expected nitrogen values in comparison with other regional populations and significant differences between children, juveniles, and adults at the site of Potočani. Bioarchaeological and stable isotope results support the interpretation that the people buried at Potočani likely experienced dietary stress in the years leading up to their violent deaths.
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- 2020
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45. Which Method of Assessing Depression and Anxiety Best Predicts Smoking Cessation: Screening Instruments or Self-Reported Conditions?
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Jennifer B. McClure, Jonathan B. Bricker, Kristin E Mull, Noreen L. Watson, and Jaimee L. Heffner
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Predictive validity ,medicine.medical_treatment ,media_common.quotation_subject ,Original Investigations ,Context (language use) ,Anxiety ,Odds ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Humans ,Medicine ,030212 general & internal medicine ,media_common ,Depression ,business.industry ,Public Health, Environmental and Occupational Health ,Abstinence ,Mental health ,Smoking cessation ,Smoking Cessation ,Self Report ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Introduction Affective disorders and symptoms (ADS) are predictive of lower odds of quitting smoking. However, it is unknown which approach to assessing ADS best predicts cessation. This study compared a battery of ADS screening instruments with a single, self-report question on predicting cessation. Among those who self-reported ADS, we also examined if an additional question regarding whether participants believed the condition(s) might interfere with their ability to quit added predictive utility to the single-item question. Methods Participants (N = 2637) enrolled in a randomized controlled trial of web-based smoking treatments completed a battery of five ADS screening instruments and answered a single-item question about having ADS. Those with a positive self-report on the single-item question were also asked about their interference beliefs. The primary outcome was complete-case, self-reported 30-day point prevalence abstinence at 12 months. Results Both assessment approaches significantly predicted cessation. Screening positive for ≥ one ADS in the battery was associated with 23% lower odds of quitting than not screening positive for any (p = .023); those with a positive self-report on the single-item had 39% lower odds of quitting than self-reporting no mental health conditions (p < .001). Area under the receiver operating characteristic curve values for the two assessment approaches were similar (p = .136). Adding the interference belief question to the single-item assessment significantly increased the area under the receiver operating characteristic curve value (p = .042). Conclusions The single-item question assessing ADS had as much predictive validity, and possibly more, than the battery of screening instruments for identifying participants at risk for failing to quit smoking. Adding a question about interference beliefs significantly increased the predictive utility of the single-item question. Implications This is the first study to demonstrate that a single-item question assessing ADS has at least as much predictive validity, and possibly more, than a battery of validated screening instruments for identifying smokers at highest risk for cessation failure. This study also demonstrates adding a question about interference beliefs significantly adds to the predictive utility of a single, self-report question about mental health conditions. Findings from this study can be used to inform decisions regarding how to assess ADS in the context of tobacco treatment settings.
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- 2020
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46. Landscape and function of multiple mutations within individual oncogenes
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Kota Yoshifuji, Satoru Miyano, Yasushi Okuno, Keisuke Kataoka, Shigeyuki Matsumoto, Junji Koya, Mitsugu Araki, Sumito Shingaki, Yuki Saito, Yuichi Shiraishi, Takanori Kanai, Yuta Isaka, Marni B McClure, Yasunori Kogure, Mariko Tabata, and Hiroko Tanaka
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0301 basic medicine ,Carcinogenesis ,Class I Phosphatidylinositol 3-Kinases ,Biology ,Oncogenicity ,medicine.disease_cause ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Bias ,Neoplasms ,medicine ,Animals ,Humans ,Missense mutation ,Cell Lineage ,Clustered Regularly Interspaced Short Palindromic Repeats ,Selection, Genetic ,Indel ,Gene ,Genetics ,Mutation ,Multidisciplinary ,Mechanism (biology) ,organic chemicals ,fungi ,Cancer ,Oncogenes ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,Function (biology) - Abstract
Sporadic reports have described cancer cases in which multiple driver mutations (MMs) occur in the same oncogene1,2. However, the overall landscape and relevance of MMs remain elusive. Here we carried out a pan-cancer analysis of 60,954 cancer samples, and identified 14 pan-cancer and 6 cancer-type-specific oncogenes in which MMs occur more frequently than expected: 9% of samples with at least one mutation in these genes harboured MMs. In various oncogenes, MMs are preferentially present in cis and show markedly different mutational patterns compared with single mutations in terms of type (missense mutations versus in-frame indels), position and amino-acid substitution, suggesting a cis-acting effect on mutational selection. MMs show an overrepresentation of functionally weak, infrequent mutations, which confer enhanced oncogenicity in combination. Cells with MMs in the PIK3CA and NOTCH1 genes exhibit stronger dependencies on the mutated genes themselves, enhanced downstream signalling activation and/or greater sensitivity to inhibitory drugs than those with single mutations. Together oncogenic MMs are a relatively common driver event, providing the underlying mechanism for clonal selection of suboptimal mutations that are individually rare but collectively account for a substantial proportion of oncogenic mutations. Analysis of genomic data from more than 60,000 cancer samples uncovers frequent multiple driver mutations in individual oncogenes, which confer enhanced oncogenicity in combination.
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- 2020
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47. Abstract GS3-08: Multiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network
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Katherine A. Hoadley, Ian E. Krop, P. Kelly Marcom, Jay Bowen, Joel S. Parker, Anna Maria Storniolo, Nancy E. Davidson, Amy Garrett, Susan G. Hilsenbeck, Rita Nanda, Claudine Isaacs, Toshinori Hinoue, Kristen M. Leraas, Chad J. Creighton, Julie M. Gastier-Foster, Antonio C. Wolff, Lisa A. Carey, Uma R. Chandran, Andrea L. Richardson, Fergus J. Couch, Carey K. Anders, Tari A. King, Benjamin J. Kelly, Minetta C. Liu, Sara E. Coppens, Salma Rezk, Elaine R. Mardis, Larry Norton, Charles M. Perou, W. Fraser Symmans, Marni B McClure, Justin M. Balko, Robyn Burns, Ben Ho Park, Adrian V. Lee, Nan Lin, Mothaffar F. Rimawi, and Peter W. Laird
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,JAM3 ,Cancer ,medicine.disease ,Primary tumor ,Metastatic breast cancer ,Metastasis ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Breast cancer ,030220 oncology & carcinogenesis ,Internal medicine ,DNA methylation ,medicine ,business ,Exome sequencing - Abstract
Background: It has become increasingly clear that effective treatment of metastatic breast cancer (MBC) requires an in-depth understanding of the molecular differences between primary tumors and metastases. The AURORA US Network was established to collect primary breast cancer-metastasis pairs for multi-platform genomic profiling in order to identify the molecular drivers of metastatic disease. AURORA US has both a retrospective and prospective phase. This is the first report of the retrospective phase. Methods: Archived tissue samples from the primary tumor and at least one distant metastasis were retrospectively collected from 83 MBC patients. Following internal quality assessment, samples from 55 pts, including 105 distinct metastatic lesions, were subject to DNA low pass whole genome and exome sequencing, DNA methylation arrays, and RNA sequencing. Early analyses of these multi-platform data include: DNA methylation, tumor gene expression and microenvironmental signatures, somatic and germline variants, DNA copy number changes, and structural variants between breast primaries and matched metastases. Results: Median age at diagnosis was 49 years (25-76); 32 (58%) were Stage I or II at presentation, 27 (49%) had a family history of breast cancer, and 20 (36%) had a second breast primary. Median disease-free interval before developing MBC was 2 years (range 0-36, 5 patients presented with Stage IV). Median overall survival from initial presentation was 4 years (range 0-37). Median survival after developing MBC was 1 year (range 0-13), with a median of three treatments. Primary tissue samples were banked from 1977-2017 and metastases were banked from 1999-2017. Clinical phenotypes of the primaries included 27 HR+ (49%), 15 triple negative (TNBC, 27%), and 11 HER2+ (20%, 12 missing HER2 status). Intrinsic subtype distribution of the primaries included 17 Basal-like (31%), 17 Luminal A (31%), 7 Normal-like (13%), 5 HER2-enriched (9%), and 1 Luminal B, with 8 pending. All metastases from the Basal-like cases remained Basal-like, while metastases from luminal primaries tended to gain HER2-Enriched subtype features (5/18, p = 0.01). Overall, we identified significant metastasis-enriched alterations in metabolism pathways, an increase in proliferation, and the loss of differentiation signatures and immune infiltrates with progression; the latter being the most pronounced in brain metastases. The most frequent somatic mutations in this cohort were in TP53, NCOR1, and RUNX1. Interestingly, ERBB2, EGFR, and ATM were also mutated in ≥10% of the tumors sequenced. In almost all cases, CpG island hypermethylation was clonally present in the primary tumor and persisted stably in the majority of metastatic lesions. Promoter CpG island hypermethylation was also identified in some metastatic lesions at JAM3, an important cellular adhesion molecule,and this was accompanied by reduced mRNA expression. CONCLUSIONS: Collection of banked primary and metastatic tissue pairs identified a young MBC cohort with a high frequency of breast cancer family history and second breast primaries. Molecular characterization of luminal tumor pairs highlighted acquisition of aggressive traits including increased proliferation and loss of differentiation in the metastases. In contrast, basal-like pairs remained relatively unchanged, except for the loss of immune activation. Ongoing analyses to be presented include clonal heterogeneity and phylogeny, novel metastasis signature discovery, gene fusion, and endogenous retrovirus detection. Citation Format: Tari A King, Minetta C Liu, Marni B McClure, Toshinori Hinoue, Benjamin J Kelly, Chad J Creighton, Jay Bowen, Kristen Leraas, Robyn T Burns, Sara Coppens, Salma Rezk, Amy L Garrett, Justin M Balko, Joel S Parker, Ben H Park, Ian Krop, Carey Anders, Katherine A Hoadley, Julie Gastier-Foster, Mothaffar F Rimawi, Rita Nanda, Nancy U Lin, Claudine Isaacs, P. Kelly Marcom, Anna Maria Storniolo, Fergus J Couch, Elaine R Mardis, Adrian V Lee, Uma Chandran, Peter W Laird, Susan G Hilsenbeck, Larry Norton, Andrea L Richardson, W. Fraser Symmans, Lisa A Carey, Antonio C Wolff, Nancy E Davidson, Charles M Perou, the AURORA US Network. Multiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr GS3-08.
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- 2020
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48. Cooperation and Cattle Herding in Eighteenth Century Acadia: Implications for Archaeological Studies of Agropastoralism
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Martin H. Welker, Joanne E. Hughes, and Sarah B. McClure
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Anthropology ,Animal Science and Zoology ,Plant Science - Published
- 2022
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49. A Developmental Examination of Amygdala Response to Facial Expressions.
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Amanda E. Guyer, Christopher S. Monk, Erin B. McClure-Tone, Eric E. Nelson, Roxann Roberson-Nay, Abby D. Adler, Stephen J. Fromm, Ellen Leibenluft, Daniel S. Pine, and Monique Ernst
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- 2008
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50. Attention alters neural responses to evocative faces in behaviorally inhibited adolescents.
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Koraly Pérez-Edgar, Roxann Roberson-Nay, Michael G. Hardin, Kaitlin Poeth, Amanda E. Guyer, Eric E. Nelson, Erin B. McClure, Heather A. Henderson, Nathan A. Fox, Daniel S. Pine, and Monique Ernst
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- 2007
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