17 results on '"B. Goke"'
Search Results
2. In Vivo Imaging of Mesenchymal Stem Cell Recruitment into the Tumor Stroma of Hepatocellular Carcinoma (HCC) Using the Sodium Iodide Symporter as Reporter Gene
- Author
-
K Knoop, M Kolokythas, C Zischek, K Klutz, MJ Willhauck, N Wunderlich, D Draganovici, C Zach, FJ Gildehaus, B Goke, E Wagner, P Nelson, and C Spitzweg
- Published
- 2010
3. Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels
- Author
-
C. Otto, B. Goke, Michael Lehrke, Bärbel Otto, Jochen Spranger, Andreas Pfeiffer, M. Vogeser, and K. G. Parhofer
- Subjects
Blood Glucose ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Peptide Hormones ,Type 2 diabetes ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Internal medicine ,Adipocyte ,medicine ,Humans ,Insulin ,Resistin ,Aged ,Glycated Hemoglobin ,Adiponectin ,Pioglitazone ,business.industry ,nutritional and metabolic diseases ,Middle Aged ,medicine.disease ,Ghrelin ,chemistry ,Diabetes Mellitus, Type 2 ,Thiazolidinediones ,Insulin Resistance ,business ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Glitazones increase the secretion of the adipocyte-derived hormone adiponectin. Furthermore, the gastric signal peptide ghrelin is known to suppress adiponectin expression in adipocyte cell culture models. It is not known whether the increase in adiponectin during glitazone therapy is due to a suppression of ghrelin levels, a decrease of resistin concentrations or an amelioration of glucose control. In 10 patients (age 71+/-9 yr, body mass index 29.9+/-3.6 kg/m(2), HbA1c 6.9+/-0.5%) with Type 2 diabetes, who had already been treated with sulfonylureas, we additionally initiated a pioglitazone therapy (30 mg/day) for 12 weeks. To investigate the pioglitazone effect independently of blood glucose, glycosylated hemoglobin (HbA1c) was kept unchanged by reducing the daily dose of sulfonylurea if necessary. Ghrelin concentration [radioimmunoassay (RIA), Phoenix Pharmaceuticals, Mountain View, CA, USA], adiponectin levels [enzyme-linked immunosorbent assay (ELISA), Biovendor, Heidelberg, Germany] as well as resistin concentrations (ELISA, Linco Research, St. Charles, MO, USA) were measured before and after pioglitazone. Glucose control remained unchanged within the 12-week pioglitazone therapy (HbA1c 6.9+/-0.5% before vs 6.8+/-0.6% after pioglitazone) while body weight increased from 86.6+/-9.2 to 88.0+/-9.4 kg (p
- Published
- 2006
4. Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus
- Author
-
M. Katschinski, B Goke, R Arnold, P Leicht, C. Beglinger, Jörg Schirra, and P Hildebrand
- Subjects
Blood Glucose ,Male ,endocrine system ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Injections, Subcutaneous ,Glucagon-Like Peptides ,Pancreatic Polypeptide ,Glucagon ,Endocrinology ,Glucagon-Like Peptide 1 ,Internal medicine ,Diabetes mellitus ,Medicine ,Humans ,Insulin ,Glycemic ,Aged ,Glucose tolerance test ,Neurotransmitter Agents ,Gastric emptying ,medicine.diagnostic_test ,business.industry ,digestive, oral, and skin physiology ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Postprandial Period ,Glucagon-like peptide-1 ,Peptide Fragments ,Postprandial ,Breath Tests ,Diabetes Mellitus, Type 2 ,Gastric Emptying ,Regression Analysis ,Female ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Twelve patients with non-insulin dependent diabetes mellitus (NIDDM) under secondary failure to sulfonylureas were studied to evaluate the effects of subcutaneous glucagon-like peptide-1(7-36)amide (GLP-1) on (a) the gastric emptying pattern of a solid meal (250 kcal) and (b) the glycemic and endocrine responses to this solid meal and an oral glucose tolerance test (OGTT, 300 kcal). 0.5 nmol/kg of GLP-1 or placebo were subcutaneously injected 20 min after meal ingestion. GLP-1 modified the pattern of gastric emptying by prolonging the time to reach maximal emptying velocity (lag period) which was followed by an acceleration in the post-lag period. The maximal emptying velocity and the emptying half-time remained unaltered. With both meals, GLP-1 diminished the postprandial glucose peak, and reduced the glycemic response during the first two postprandial hours by 54.5% (solid meal) and 32.7% (OGTT) (P < 0.05). GLP-1 markedly stimulated insulin secretion with an effect lasting for 105 min (solid meal) or 150 min (OGTT). The postprandial increase of plasma glucagon was abolished by GLP-1. GLP-1 diminished the postprandial release of pancreatic polypeptide. The initial and transient delay of gastric emptying, the enhancement of postprandial insulin release, and the inhibition of postprandial glucagon release were independent determinants (P < 0.002) of the postprandial glucose response after subcutaneous GLP-1. An inhibition of efferent vagal activity may contribute to the inhibitory effect of GLP-1 on gastric emptying.
- Published
- 1998
5. Binding, internalization, and processing of bombesin by rat pancreatic acini
- Author
-
Wen-Yu Zhu, John A. Williams, and B. Goke
- Subjects
Male ,medicine.medical_specialty ,Physiology ,media_common.quotation_subject ,Neuropeptide ,Down-Regulation ,Biology ,digestive system ,complex mixtures ,Binding, Competitive ,chemistry.chemical_compound ,Acinus ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Internalization ,Pancreas ,Chromatography, High Pressure Liquid ,media_common ,Hepatology ,Gastroenterology ,Temperature ,Bombesin ,Rats, Inbred Strains ,Ligand (biochemistry) ,In vitro ,Bombesin receptor ,Rats ,Receptors, Neurotransmitter ,Receptors, Bombesin ,Kinetics ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Biophysics ,Steady state (chemistry) ,hormones, hormone substitutes, and hormone antagonists - Abstract
The binding and subsequent fate of 125I-labeled bombesin was studied in rat pancreatic acini. At both 37 degrees C and 4 degrees C binding occurred to a single saturable site, with Kd equal to 1.7 nM. The amount of steady-state tracer binding was reduced at 4 degrees C (5.7%/mg protein) compared with 37 degrees C (8.7%/mg), with a similar relative change in calculated binding capacity. With the use of an acid wash procedure to remove surface bound ligand, 55% of cell-associated 125I-bombesin was internalized in the steady state at 37 degrees C but only 5% at 4 degrees C. Preincubation at 4 degrees C followed by an increase to 37 degrees C led to rapid internalization of bound bombesin, which was blocked by the metabolic inhibitor antimycin. 125I-bombesin was found to be degraded by two acinar systems. One was not related to receptor binding but could be inhibited with bacitracin. The other occurred after internalization and was partially blocked with chloroquine. Thus, after binding, bombesin is internalized, and the degradation products are released from the cell. Exposure to bombesin is also accompanied by a subsequent decrease in cell surface binding (54% after 1 h exposure to 100 nM bombesin), suggesting that the bombesin receptor may also be internalized in a ligand-dependent manner.
- Published
- 1991
6. Mo-P6:432 Genetic variants of adipor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels
- Author
-
E. Fleischer-Brielmaier, B. Goke, Jutta M. Nagel, P. Lohse, A. B. Tietz, Michael Lehrke, Uli C. Broedl, and Klaus G. Parhofer
- Subjects
medicine.medical_specialty ,Endocrinology ,Adiponectin ,Internal medicine ,Internal Medicine ,medicine ,Genetic variants ,General Medicine ,Biology ,Triglyceride VLDL ,Cardiology and Cardiovascular Medicine - Published
- 2006
7. Validity and reliability study of the Turkish version of SACRAH (Score for Assessment and quantification of Chronic Rheumatic Affections of the Hands)
- Author
-
N.G. Tore, F. Sari, Z. Tuna, O. Varan, H. Babaoglu, B. Goker, and D. Oskay
- Subjects
Hand ,SACRAH ,questionnaire ,reliability ,validity. ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Rheumatic diseases cause deformities in the hands and affect daily living activities. Therefore, assessment of hand disabilities is important in rheumatic disease. The aim of this study was to test the validity and reliability of the Turkish version of the A Score For Assessment and Quantification of Chronic Rheumatic Affections of the Hands (SACRAH). A translation and back-translation of the SACRAH were performed, according to the Beaton guidelines. Patients who were between 18-65 years old, who were literate in Turkish, who had rheumatic disease diagnosis and whose hands were affected, were included in the study. Patients who were using a splint during daytime were excluded from the study. They completed the Turkish version of Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH-T) once and the final version of the SACRAH Questionnaire twice with a 7 days’ interval. The internal consistency (Cronbach’s α) and reliability (test-retest reliability) of the questionnaire were assessed. Besides, correlations between SACRAH and DASH-T scores were analyzed using the Spearman correlation coefficient. One hundred and twenty patients participated in the study. The Turkish version of the SACRAH met set criteria of reliability and validity. Internal consistency was excellent (Cronbach’s α=0.88) and test-retest reliability were very good (r=0.73). SACRAH showed a positive and statistically significant correlation with DASH-T scores (r=0.83, p
- Published
- 2019
- Full Text
- View/download PDF
8. Changes in pattern of enzyme secretion by rat pancreas during repeated trypsin inhibitor treatment
- Author
-
V. Keim, G. Adler, and B. Goke
- Subjects
Camostat ,medicine.medical_specialty ,Gabexate ,Physiology ,Trypsin inhibitor ,Bicarbonate ,Biology ,Guanidines ,chemistry.chemical_compound ,Reference Values ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Secretion ,Amylase ,Pancreas ,Cholecystokinin ,Hepatology ,Gastroenterology ,Esters ,Rats, Inbred Strains ,Lipase ,Rats ,Isoenzymes ,Bicarbonates ,Kinetics ,Endocrinology ,Secretory protein ,chemistry ,Pancreatic juice ,Amylases ,biology.protein ,Female ,Trypsin Inhibitors ,Peptide Hydrolases - Abstract
In conscious rats with cannulated pancreatic ducts, the synthetic trypsin inhibitor camostat (400 mg/kg) was instilled into the stomach once daily on 5 consecutive days. Each camostat administration stimulated the secretion of juice, bicarbonate, and protein. From day 2 to day 5, basal protein secretion measured before the daily instillation of camostat was increased, whereas basal secretion of volume and bicarbonate remained unchanged. The secretory responses to camostat increased up to day 3 of treatment without further change on days 4 and 5. In response to acute camostat instillation, parallel secretion of enzymes was found. Within 1 day, however, a change in the composition of secreted enzymes was observed. After 3 days, the percentage of amylase in pancreatic juice decreased by approximately 50%, whereas the relative amount of proteinases and the specific activity of phospholipase A2 doubled. The alteration of protein patterns in pancreatic juice parallels the effect on enzymes stored in the gland. The results demonstrate that adaptation of enzyme secretion in the exocrine pancreas occurs after a short period of treatment with camostat. Because this compound stimulated protein, volume, and bicarbonate secretion, it is suggested that other factors in addition to cholecystokinin may be involved in this adaptation process.
- Published
- 1988
9. Sjögren’s syndrome and mean platelet volume
- Author
-
M. E. Tezcan, Ş. Demir, M. Sargın, M. Aliustaoğlu, and B. Göker
- Subjects
Letter to the Editor ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Not required
- Published
- 2015
- Full Text
- View/download PDF
10. Oesophageal ulceration after selective internal radiation therapy in a patient with carcinoma of unknown primary.
- Author
-
Kubisch CH, Beigel F, Ihrler S, Goke B, Reiser MF, and Hoffmann RT
- Subjects
- Adenocarcinoma blood supply, Adenocarcinoma drug therapy, Adenocarcinoma surgery, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Disease Progression, Duodenum pathology, Duodenum radiation effects, Endoscopy, Digestive System, Esophagus pathology, Female, Gastric Mucosa pathology, Gastric Mucosa radiation effects, Hepatectomy, Humans, Intestinal Mucosa pathology, Intestinal Mucosa radiation effects, Liver Neoplasms blood supply, Liver Neoplasms drug therapy, Liver Neoplasms surgery, Microspheres, Middle Aged, Neoadjuvant Therapy, Neoplasms, Unknown Primary blood supply, Neoplasms, Unknown Primary drug therapy, Neoplasms, Unknown Primary surgery, Radiotherapy, Adjuvant, Adenocarcinoma radiotherapy, Adenocarcinoma secondary, Brachytherapy adverse effects, Duodenal Ulcer pathology, Embolization, Therapeutic, Esophageal Diseases pathology, Esophagus radiation effects, Liver Neoplasms radiotherapy, Liver Neoplasms secondary, Neoplasms, Unknown Primary radiotherapy, Radiation Injuries pathology, Stomach Ulcer pathology, Ulcer pathology
- Abstract
Background: Cancer of unknown primary (CUP) is defined as histologically confirmed metastases in the absence of an identifiable primary tumor. Patients with solely liver metastases from adenocarinomas represent the most frequent subgroup with an unfavourable prognosis. The medium survival averages 6 to 9 months. No chemotherapheutic standard has been established., Case: We present a patient with hepatic CUP. After cycles of chemotherapy and hemihepatectomy the tumor returned and showed hepatic progression. The patient was evaluated for selective internal radiation therapy (SIRT). Three years after diagnosis she is still alive and tumorfree. Despite a good result and disease control our patient suffered radiation-induced ulceration in the oesophagus, stomach, and duodenum. This side effect appears in up to 12 % of patients, often very late after treatment, is refractory to pharmacotherapy and persistent over a long time., Conclusions: SIRT is a new, effective treatment in patients with hepatic CUP. Because of the anticipated increase of this therapy, adverse side effects such as ulcerations in the upper-GI tract secondary to ectopic implantation of microspheres may be seen more commonly. Awareness of this and the recognition of microspheres in biopsies is cardinal for appropriate management and maintenance of the patient's quality of life.
- Published
- 2010
- Full Text
- View/download PDF
11. Chemoembolization combined with pravastatin improves survival in patients with hepatocellular carcinoma.
- Author
-
Graf H, Jüngst C, Straub G, Dogan S, Hoffmann RT, Jakobs T, Reiser M, Waggershauser T, Helmberger T, Walter A, Walli A, Seidel D, Goke B, and Jüngst D
- Subjects
- Aged, Antibiotics, Antineoplastic administration & dosage, Carcinoma, Hepatocellular mortality, Combined Modality Therapy, Epirubicin administration & dosage, Female, Germany epidemiology, Humans, Kaplan-Meier Estimate, Liver Neoplasms mortality, Male, Middle Aged, Prospective Studies, Carcinoma, Hepatocellular therapy, Chemoembolization, Therapeutic, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Liver Neoplasms therapy, Pravastatin therapeutic use
- Abstract
Background/aims: Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been shown to inhibit growth and to induce apoptosis in human hepatocellular carcinoma (HCC) cells. However, the potential benefit of pravastatin in HCC patients has still not been characterized, which prompted us to test the efficacy of pravastatin in patients with advanced HCC., Methods: We investigated prospectively a cohort of 183 HCC patients who had been selected for palliative treatment by transarterial chemoembolization (TACE). Fifty-two patients received TACE combined with pravastatin (20-40 mg/day) and 131 patients received chemoembolization alone. Six independent predictors of survival according to the Vienna survival model for HCC were equally distributed in both groups., Results: During the observation period of up to 5 years, 31 (23.7%) out of 131 patients treated by TACE alone and 19 (36.5%) out of 52 patients treated by TACE and pravastatin survived. Median survival was significantly longer in HCC patients treated by TACE and pravastatin (20.9 months, 95% CI 15.5-26.3, p = 0.003) than in HCC patients treated by TACE alone (12.0 months, 95% CI 10.3-13.7)., Conclusion: Combined treatment of chemoembolization and pravastatin improves survival of patients with advanced HCC in comparison to patients receiving chemoembolization alone., (2008 S. Karger AG, Basel.)
- Published
- 2008
- Full Text
- View/download PDF
12. Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis.
- Author
-
Stathopoulos P, Zundt B, Spelsberg FW, Kolligs L, Diebold J, Goke B, and Jungst D
- Subjects
- Atrophy, Biopsy, Chi-Square Distribution, Cholecystectomy, Laparoscopic, Cholecystolithiasis surgery, Endoscopy, Gastrointestinal, Female, Gastric Mucosa microbiology, Gastritis microbiology, Humans, Male, Middle Aged, Statistics, Nonparametric, Cholecystolithiasis physiopathology, Gastric Mucosa physiopathology, Gastritis physiopathology, Helicobacter Infections physiopathology, Helicobacter pylori
- Abstract
Background: Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease. However, the additional pathogenetic role of an impaired gallbladder function leading to an increased alkaline duodenogastric reflux is controversially discussed., Aim: To investigate the relation of gallbladder function and Hp infection to gastric mucosa inflammation in patients with symptomatic gallstones prior to cholecystectomy., Patients: Seventy-three patients with symptomatic gallstones were studied by endoscopy and Hp testing., Methods: Gastritis classification was performed according to the updated Sydney System and gallbladder function was determined by total lipid concentration of gallbladder bile collected during mainly laparoscopic cholecystectomy., Results: Fifteen patients revealed no, 39 patients mild, and 19 moderate to marked gastritis. No significant differences for bile salts, phospholipids, cholesterol, or total lipids in gallbladder bile were found between these three groups of patients. However, while only 1 out of 54 (<2%) patients with mild or no gastritis was found histologically positive for Hp, this infection could be detected in 14 (74%) out of 19 patients with moderate to marked gastritis., Conclusion: Moderate to marked gastric mucosa inflammation in gallstone patients is mainly caused by Hp infection, whereas gallbladder function is not related to the degree of gastritis. Thus, an increased alkaline duodenogastric reflux in gallstone patients seems to be of limited pathophysiological relevance.
- Published
- 2006
- Full Text
- View/download PDF
13. Role of the intracellular receptor domain of gp130 (exon 17) in human inflammatory bowel disease.
- Author
-
Auernhammer CJ, Zitzmann K, Schnitzler F, Seiderer J, Lohse P, Vlotides G, Engelhardt D, Sackmann M, Goke B, and Ochsenkuhn T
- Subjects
- Adult, Aged, Antigens, CD chemistry, Cytokine Receptor gp130, Exons, Female, Humans, Male, Membrane Glycoproteins chemistry, Middle Aged, Protein Structure, Tertiary, Antigens, CD genetics, Colitis, Ulcerative genetics, Crohn Disease genetics, Membrane Glycoproteins genetics
- Abstract
Aim: To study the role of the intracellular receptor domain of gp130 in human inflammatory bowel disease (IBD)., Methods: We amplified and sequenced the complete exon 17 of the human gp130 gene in 146 patients with IBD. According to clinical and histopathological signs, the 146 patients with IBD were classified as having Crohn's disease (n = 73) or ulcerative colitis (n = 63), or as indeterminate status (n = 10)., Results: No mutations in exon 17 of the gp130 gene could be detected in any of the 146 patients with IBD examined., Conclusion: There is no evidence that mutations in exon 17 of the gp130 gene are involved in the pathogenesis of human IBD.
- Published
- 2005
- Full Text
- View/download PDF
14. Herbal extracts modulate the amplitude and frequency of slow waves in circular smooth muscle of mouse small intestine.
- Author
-
Storr M, Sibaev A, Weiser D, Kelber O, Schirra J, Goke B, and Allescher HD
- Subjects
- Animals, Electrophysiology, Male, Membrane Potentials, Mice, Mice, Inbred BALB C, Tissue Culture Techniques, Gastrointestinal Motility drug effects, Herbal Medicine, Intestine, Small drug effects, Intestine, Small physiology, Muscle, Smooth drug effects, Muscle, Smooth physiology, Plant Extracts pharmacology
- Abstract
Background: Herbal preparations like STW 5 (Iberogast) are widely used drugs in the treatment of dyspepsia and motility-related disorders of the gastrointestinal tract. STW 5 is a phytotherapeutic agent consisting of a fixed mixture of 9 individual plant extracts. The electrophysiological mechanisms of action of STW 5 remain obscure., Aim: The aim of the present study was to investigate whether herbal extracts influence electrophysiological parameters of the small intestine. For this purpose, the resting membrane potential (RMP) and the slow wave rhythmicity of smooth muscle cells of mouse small intestine were observed., Methods: Intracellular recordings of smooth muscle cells of the circular muscle layer of mouse small intestine were performed using standard microelectrode techniques. After dissection of the mucosa, the small intestine was placed in an organ bath and a microelectrode was applied on a circular smooth muscle cell. The RMP and the amplitude of slow waves were measured in millivolts., Results: The RMP of smooth muscle cells was -59 +/- 1.3 mV. This RMP was significantly depolarized by STW 5 (9.6 +/- 1.6 mV); the depolarizing effects can be mainly attributed to the constituents of matricariae flos, angelicae radix and chelidonii herba. The basal frequency of small intestinal slow waves was 39.5 +/- 1.4 min(-1) and the amplitude was 23.1 +/- 0.9 mV. STW 5 significantly reduced the amplitude and frequency of the slow waves (11.7 +/- 0.8 mV; 33.5 +/- 3.4 min(-1)). This effect on slow waves represents the sum of the effects of the 9 phytoextracts. Whereas angelicae radix and matricariae flos completely blocked slow wave activity, Iberis amara increased the frequency and amplitude, chelidonii herba reduced the frequency and amplitude of the slow waves, mentae piperitae folium reduced the frequency and left amplitude unchanged and liquiritae radix, carvi fructus and melissae folium had no effects., Conclusion: Herbal extracts cause changes in smooth muscle RMP and slow wave rhythmicity, up to reversible abolition, by blockade of large conductance Ca2+ channels and other not yet identified mechanisms. In herbal preparations like STW 5 these effects add up to a total effect and this study indicates that herbal preparations which are widely used in dyspepsia and motility-related disorders have characteristic, reproducible, reversible effects on small intestinal electrophysiology.
- Published
- 2004
- Full Text
- View/download PDF
15. International symposium on glucagonlike peptide I, Copenhagen, Denmark, 17-19 May 1993.
- Author
-
Fehmann HC and Goke B
- Published
- 1993
- Full Text
- View/download PDF
16. Tryptophan rich diet as a new approach to study the serotoninergic enteropancreatic axis.
- Author
-
Goke B, Richter G, Keim V, and Arnold R
- Subjects
- Animals, Female, Rats, Rats, Inbred Strains, Intestine, Small metabolism, Pancreas metabolism, Serotonin metabolism, Tryptophan pharmacology
- Abstract
The influence of a tryptophan enriched diet (L-tryptophan added as 1% of total diet), fed over 10 days, on the rat duodenum and pancreas was studied by immunohistology, measurements of serotonin and tryptophan tissue concentrations by HPLC, and incubations of pancreatic lobules. Ingestion of a tryptophan enriched diet resulted in increased contents of tryptophan and serotonin in the duodenum that was not accompanied by a significant change of the serotonin cell density. Neither basal nor CCK-stimulated amylase release from isolated pancreatic lobules was altered after tryptophan enriched food. Although serotonin could be extracted from the pancreas, no increase in serotonin concentration was detected after ingestion of the tryptophan diet. A 'serotonin loading' diet may be a useful tool to study the significance of amines produced by gut endocrine cells in respects to enteropancreatic connections.
- Published
- 1987
- Full Text
- View/download PDF
17. Effect of pancreatic atrophy and hypertrophy on the small intestine.
- Author
-
Adler G, Hausmann W, Elsebach K, Goke B, Lorenz-Meyer H, Herberg L, and Arnold R
- Subjects
- Adaptation, Physiological, Animals, Exocrine Pancreatic Insufficiency pathology, Mice, Mice, Inbred CBA, Intestine, Small physiology
- Abstract
Intestinal enzyme activities were investigated in mice with spontaneously occurring exocrine pancreatic insufficiency (EPI), in rats after induction of pancreatic insufficiency by intraductal injection of oleic acid, and in rats after feeding a proteinase inhibitor (Camostate) which induced a marked pancreatic hypertrophy. An increase in saccharase activity and in vitro uptake of L-phenylalanine was found in EPI mice, while activities of alkaline phosphatase and lactase were not altered. In oleic acid induced pancreatic insufficiency and in pancreatic hypertrophy no alterations in enzyme activities were observed. Morphometric analysis revealed no alterations in mucosal surface of EPI mice. It was suggested that the small intestine adapts fuctionally to severe and long lasting pancreatic insufficiency, but not to pancreatic hypertrophy.
- Published
- 1987
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.