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Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus
- Source :
- The Journal of endocrinology. 156(1)
- Publication Year :
- 1998
-
Abstract
- Twelve patients with non-insulin dependent diabetes mellitus (NIDDM) under secondary failure to sulfonylureas were studied to evaluate the effects of subcutaneous glucagon-like peptide-1(7-36)amide (GLP-1) on (a) the gastric emptying pattern of a solid meal (250 kcal) and (b) the glycemic and endocrine responses to this solid meal and an oral glucose tolerance test (OGTT, 300 kcal). 0.5 nmol/kg of GLP-1 or placebo were subcutaneously injected 20 min after meal ingestion. GLP-1 modified the pattern of gastric emptying by prolonging the time to reach maximal emptying velocity (lag period) which was followed by an acceleration in the post-lag period. The maximal emptying velocity and the emptying half-time remained unaltered. With both meals, GLP-1 diminished the postprandial glucose peak, and reduced the glycemic response during the first two postprandial hours by 54.5% (solid meal) and 32.7% (OGTT) (P < 0.05). GLP-1 markedly stimulated insulin secretion with an effect lasting for 105 min (solid meal) or 150 min (OGTT). The postprandial increase of plasma glucagon was abolished by GLP-1. GLP-1 diminished the postprandial release of pancreatic polypeptide. The initial and transient delay of gastric emptying, the enhancement of postprandial insulin release, and the inhibition of postprandial glucagon release were independent determinants (P < 0.002) of the postprandial glucose response after subcutaneous GLP-1. An inhibition of efferent vagal activity may contribute to the inhibitory effect of GLP-1 on gastric emptying.
- Subjects :
- Blood Glucose
Male
endocrine system
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Injections, Subcutaneous
Glucagon-Like Peptides
Pancreatic Polypeptide
Glucagon
Endocrinology
Glucagon-Like Peptide 1
Internal medicine
Diabetes mellitus
Medicine
Humans
Insulin
Glycemic
Aged
Glucose tolerance test
Neurotransmitter Agents
Gastric emptying
medicine.diagnostic_test
business.industry
digestive, oral, and skin physiology
Glucose Tolerance Test
Middle Aged
medicine.disease
Postprandial Period
Glucagon-like peptide-1
Peptide Fragments
Postprandial
Breath Tests
Diabetes Mellitus, Type 2
Gastric Emptying
Regression Analysis
Female
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 00220795
- Volume :
- 156
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of endocrinology
- Accession number :
- edsair.doi.dedup.....2dd0cd4266c193cfd44cba7d131cfa08