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1. M550 LYMPHOID HYPEREOSINOPHILIC SYNDROME WITH CUTANEOUS INVOLVEMENT SUCCESSFULLY TREATED WITH TOFACITINIB

Author: B. Bochner, J. Choi, B. McNeil, F. Kuang, and M. Chen
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tofacitinib, Cutaneous Involvement, Hypereosinophilic syndrome, business.industry, Immunology, medicine, Immunology and Allergy, medicine.disease, business, Dermatology
Published: 2020
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2. Spécificités moléculaires des tumeurs de la voie excrétrice urinaire supérieure

Author: Jonathan A. Coleman, E. Pietzak, Aditya Bagrodia, Hikmat Al-Ahmadie, M. Donoghue, B. Bochner, T. Donahue, Sumit Isharwal, Gopa Iyer, François Audenet, M. Arcila, Jonathan E. Rosenberg, Eugene K. Cha, David B. Solit, G. Dalbagni, B. Taylor, John P. Sfakianos, M. Berger, and Dean F. Bajorin
Subjects: Gynecology, medicine.medical_specialty, business.industry, Urology, Medicine, business
Abstract: Objectifs Les tumeurs urotheliales de la voie excretrice urinaire superieure (TVES) presentent la meme histologie que les tumeurs urotheliales de vessie (TV). Pourtant, les TVES ont des caracteristiques cliniques specifiques, des facteurs de risque qui leur sont propres et sont plus frequentes que les TV dans les syndromes de lynch. L’objectif de cette etude etait de rechercher s’il existe des differences moleculaires entre TVES et TV. Methodes Nous avons sequence la tumeur et l’ADN germinal correspondant de 195 patients avec une tves en utilisant une plateforme de sequencage de nouvelle generation basee sur la capture ciblee d’un panel de 341 oncogenes. En comparaison, 454 patients avec une TV sans antecedent de TVES ont ete inclus. Les mutations ont ete regroupees par voie de carcinogenese et comparees en fonction du stade tumoral entre TVES et TV, apres ajustement pour comparaisons multiples. Resultats Lors de la progression vers un stade avance, les TVES presentaient moins de mutations de la voie RTK/RAS mais plus de mutations de TP53/MDM2. Par rapport aux TV, TP53, RB1 et ERBB2 etaient moins frequemment mutes dans les TVES (26 vs. 46 %, 3 vs. 20 %, 8 vs. 19 %, respectivement ; q Fig. 1 ). Le nombre median de mutations somatiques/mb etait significativement plus eleve dans les TVES (13,2 [IQR : 7,4–19,1] vs. 8,8 [IQR : 5,9–15,4] ; p Conclusion TVES et TV presentent des differences significatives dans la prevalence des mutations somatiques, suggerant des mecanismes de carcinogenese differents. Le sequencage des TVES donne des informations qui peuvent potentiellement guider les traitements systemiques et permet de detecter les patients a risque de syndrome de lynch.
Published: 2018
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3. Classification phylogénétique des récidives vésicales après tumeur de la voie excrétrice urinaire supérieure

Author: François Audenet, G. Dalbagni, B. Taylor, M. Arcila, E. Pietzak, Eugene K. Cha, T. Donahue, John P. Sfakianos, M. Donoghue, Aditya Bagrodia, Jonathan A. Coleman, David B. Solit, Sumit Isharwal, B. Bochner, Dean F. Bajorin, M. Berger, Gopa Iyer, Jonathan E. Rosenberg, and Hikmat Al-Ahmadie
Subjects: Gynecology, medicine.medical_specialty, business.industry, Urology, medicine, business
Abstract: Objectifs Apres le traitement d’une tumeur de la voie excretrice urinaire superieure (TVES), les tumeurs de vessie (TV) sont frequentes, avec une incidence de 22 a 47 %. Plusieurs theories s’opposent pour expliquer leur origine : monoclonalite par dispersion intraluminale et implantation cellulaire ou oligoclonalite par cancerisation en plage de l’urothelium. L’objectif de cette etude etait de comparer le profil moleculaire entre TVES et TV metachrones. Methodes Nous avons sequence la tumeur et l’ADN germinal correspondant de 137 patients avec une tves traitee par nephroureterectomie en utilisant une plateforme de sequencage de nouvelle generation basee sur la capture ciblee d’un panel de 341 oncogenes. Les mutations somatiques ont ete analysees en fonction du risque de recidive vesicale. Pour un sous-groupe de 29 patients avec une TV metachrone, TVES et TV ont ete comparees chez le meme patient pour definir leur clonalite. Resultats Au total, 57 patients (42 %) ont developpe une tumeur de vessie apres nephroureterectomie, avec un delai median de 7,3 mois (IQR : 4,1–13,7). Apres ajustement pour le sexe, les antecedents de TV, la localisation, le grade et le stade tumoral, les mutations de FGFR3 (hr = 3,00 ; 95 % IC : 1,58–5,68 ; p = 0,001), KDM6A (hr = 2,27 ; 95 % IC : 1,29–4,02 ; p = 0,005) et CCND1 (hr = 3,10 ; 95 % IC : 1,17–8,21 ; p = 0,023) etaient significativement associees au risque de recidive vesicale, alors que les mutations de TP53 etaient significativement associees a une reduction du risque (hr = 0,32 ; 95 % IC : 0,13–0,80 ; p = 0,014). Chez les 29 patients presentant les 2 tumeurs de maniere metachrone, TVES et TV etaient toujours clonales ( Fig. 1 ). Conclusion Alors que TVES et TV presentent des differences significatives dans la prevalence des mutations somatiques, chez un meme patient presentant les 2 tumeurs, TVES et TV sont clonales. Cela implique une meilleure prevention du risque de dissemination intraluminale en peroperatoire, notamment pour les tumeurs presentant des facteurs de risque moleculaires.
Published: 2018
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4. P024 Dress syndrome secondary to lamotrigrine complicated by myocarditis, heart failure and a polytypic B-cell subpopulation

Author: B. Bochner, P. Greenberger, and L. Cuervo-Pardo
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Myocarditis, business.industry, Immunology, medicine.disease, medicine.anatomical_structure, Heart failure, Internal medicine, medicine, Cardiology, Immunology and Allergy, business, B cell
Published: 2017
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5. Should robotic radical cystectomy become a new standard: Results of a prospective, randomized study

Author: B. Bochner
Subjects: Cystectomy, medicine.medical_specialty, business.industry, Urology, General surgery, medicine.medical_treatment, medicine, Prospective randomized study, business
Published: 2016
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6. THE LIGO GRAVITATIONAL WAVE OBSERVATORIES: RECENT RESULTS AND FUTURE PLANS

Author: Robert Spero, Soumya D. Mohanty, Alessandra Buonanno, N. Zotov, K. Mason, B. Lantz, David Crooks, Sanichiro Yoshida, Graham Woan, E. Rotthoff, Xavier Siemens, M. Malec, M. Rakhmanov, S. Penn, Karsten Kötter, Rana X. Adhikari, Yi Chen, Q. Z. Shu, G. Stapfer, J. Hanson, B. Machenschalk, Guido Mueller, Pamela J. Russell, S. Richman, Oliver Jennrich, J. Betzwieser, H. Overmier, J. H. Romie, B. Sears, Anton B. Ivanov, C. Colacino, M. Schrempel, N. Hindman, D. Farnham, Vicky Kalogera, Carsten Fallnich, J. Mason, T. Regimbau, M. Coles, M. Guenther, Michael D. Smith, R. Amin, K. Bayer, F. J. Raab, R. Gustafson, V. Schmidt, I. Salzman, Patrick Brady, C. Barker-Patton, C. I. Torrie, M. A. Barton, F. Mann, A. Heptonstall, C. Hardham, R. M. S. Schofield, S. Chatterji, Benjamin J. Owen, W. R. Johnston, Alberto Vecchio, K. V. Tokmakov, Seiji Kawamura, Morag M. Casey, Adrian C. Ottewill, Phil Willems, M. Heurs, J. Chapsky, B. J. Winjum, J. Zweizig, Osamu Miyakawa, David H. Reitze, D. Ouimette, Albert Lazzarini, K. Mailand, Christian J. Killow, Peter R. Saulson, V. V. Frolov, R. Taylor, M. Hammond, H. Ding, Krzysztof Belczynski, R. Mittleman, R. Abbott, Nelson Christensen, A. Hartunian, D. M. Strom, J. Kern, Philippe Grandclément, P. J. Sutton, Haisheng Rong, L. Jones, Robert Bennett, S. Brozek, A. Rizzi, Keisuke Goda, Lindon J. Robison, R. L. Savage, Helena Armandula, E. J. Elliffe, Curt Cutler, P. Kloevekorn, D. Rose, M. C. Araya, B. F. Schutz, T. Summerscales, D. Chin, M. M. Fejer, Stanislav Babak, Walid A. Majid, I. Leonor, S. Wen, P. Ehrens, S. Traeger, Peter Fritschel, A. L. Stuver, I. Yakushin, C. Gray, Duncan A. Brown, G. Billingsley, A. Chandler, D. B. Tanner, J. G. Rollins, Kevin M. Ryan, F. Asiri, S. E. Whitcomb, S. Nagano, Timothy Evans, D. Redding, Shinji Miyoki, M. J. Lubinski, A. M. Gretarsson, Chonghoon Kim, T. Delker, D. Sigg, Brent Ware, S. W. Ballmer, C. Aulbert, S. J. Berukoff, G. Traylor, Thomas Corbitt, J. Castiglione, G. Moreno, Akiteru Takamori, Walter Winkler, P. Charlton, A. Gillespie, Harald Lück, J. Logan, R. K. Nayak, A. Wilson, C. Messenger, Vladimir B. Braginsky, K. Riles, R. Rahkola, V. Leonhardt, T. Etzel, Rainer Weiss, D. Debra, O. Matherny, Laura Cadonati, D. Jungwirth, P. Hoang, P. R. Williams, R. W. P. Drever, I. A. Bilenko, Ian Taylor, Robert J. McCarthy, Linqing Wen, David J. Ottaway, Sheila Rowan, B. Barr, J. Worden, Teviet Creighton, Herbert Walther, M. Hrynevych, K. Kawabe, Joseph D. Romano, Yousuke Itoh, W. W. Johnson, C. King, R. Riesen, Roland Schilling, Kasem Mossavi, F. Nocera, Martin Hewitson, B. Bochner, Alicia M. Sintes, Massimo Tinto, H. Tariq, D. Webber, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, E. Black, Gianpietro Cagnoli, Gregory M. Harry, M. Lei, J. R. Smith, R. Bork, J. E. Brau, C. A. Cantley, T. Nash, T. Olson, A. Sazonov, D. Churches, Benjamin William Allen, A. Khan, S. M. Scott, D. Ugolini, Karsten Danzmann, M. C. Sumner, Virginio Sannibale, David E. McClelland, Kenneth A. Strain, M. Lormand, Erika D'Ambrosio, J. Myers, C. Ebeling, J. A. Giaime, G. Mendell, U. Weiland, E. J. Daw, M. Fine, T. T. Lyons, S. Wise, S. Grunewald, C. Parameswariah, N. Hepler, B. Mours, J. Langdale, G. P. Newton, M. Fyffe, Kip S. Thorne, Suvadeep Bose, Richard Ingley, A. J. Weinstein, D. H. Shoemaker, Gabriela Gonzalez, M. Landry, Kenneth G. Libbrecht, D. B. Kozak, M. Hennessy, C. Vorvick, B. O'Reilly, R.L. Coldwell, A. Weidner, V. P. Mitrofanov, L. Bogue, M. R. Smith, P. Schwinberg, A. Grant, S. Liu, Michael E Zucker, L. Zhang, G. H. Sanders, R. Lawrence, W. G. Anderson, Jordan Camp, A. S. Sengupta, Peter Shawhan, M. Tibbits, B. P. Abbott, S. Vass, Peter Aufmuth, W. Kells, D. Busby, R. Davies, William E. Butler, Albrecht Rüdiger, V. Chickarmane, S. Meshkov, R. Beausoleil, Martin P McHugh, M. H. P. M. van Putten, S. Tilav, E. Gustafson, H. Naundorf, M. R. Pratt, Matthew Evans, L. Cardenas, E. Maros, S. Klimenko, Marco Aurelio Diaz, B. Bhawal, V. Parameswariah, C. Torres, N. A. Robertson, A. Bullington, Kevin M. Carter, S. B. Anderson, M. W. Regehr, A. Marin, M. Pedraza, Badri Krishnan, P. Csatorday, Maria Alessandra Papa, M. V. Plissi, Antony C. Searle, Kent Blackburn, Hartmut Grote, B. F. Whiting, Joseph M. Kovalik, M. Barnes, Julien Sylvestre, P. McNamara, L. Wallace, R. Frey, H. Yamamoto, P. J. King, D. Grimmett, Philip Nutzman, A. G. Wiseman, P. E. Lindquist, D. C. Coyne, S. Dhurandar, W. O. Hamilton, D. Barker, Kenneth D. Skeldon, S. Killbourn, S. Roddy, James Whelan, Lee Samuel Finn, Éanna É. Flanagan, Guenakh Mitselmakher, A. Ageev, L. Sievers, C. A. Shapiro, B. Bland-Weaver, Soma Mukherjee, Scott Koranda, L. Matone, J. H. Hough, A. Sibley, Douglas R. Cook, S. Seel, M. Ito, Roy Williams, K. S. Ganezer, K. Watts, Stefan Goßler, K. T. Reilly, Kevin C. Schlaufman, Herbert Welling, Nergis Mavalvala, B. C. Barish, J. Heefner, W. Hua, Michele Vallisneri, Ik Siong Heng, S. Márka, R. J. Dupuis, K. Reithmaier, Andreas Freise, Matthew Pitkin, R. DeSalvo, R. Wooley, Jolien D. E. Creighton, I. Zawischa, E. Katsavounidis, R. L. Byer, H. Radkins, S. P. Vyachanin, W. Tyler, R. Balasubramanian, Jeffrey A. Edlund, R. Burgess, B. J. Cusack, S. R. Rao, D. I. Robertson, Peter H. Sneddon, M. Mageswaran, H. Ward, M. MacInnis, Y. Hefetz, Gerhard Heinzel, Benno Willke, and The LIGO Scientific Collaboration
Subjects: Physics, Gravitational-wave observatory, Einstein Telescope, Gravitational wave, Astrophysics::High Energy Astrophysical Phenomena, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astrophysics, Gravitational-wave astronomy, LIGO, General Relativity and Quantum Cosmology, Neutron star, Pulsar, QC
Abstract: The LIGO interferometers are operating as gravitational wave observatories, with a noise level near an order of magnitude of the goal and the first scientific data recently taken. This data has been analyzed for four different categories of gravitational wave sources; millisecond bursts, inspiralling binary neutron stars, periodic waves from a known pulsar, and stochastic background. Research and development is also underway for the next generation LIGO detector, Advanced LIGO.
Published: 2006
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7. Search for gravitational waves from binary black hole inspirals in LIGO data

Author: Linqing Wen, T. Etzel, Joseph D. Romano, C. King, Kasem Mossavi, J. E. Brau, W. R. Johnston, Laura Cadonati, K. Kawabe, P. Csatorday, A. Chandler, Kevin M. Ryan, J. Betzwieser, D. Debra, W. Kells, Lindon J. Robison, A. Wilson, A. L. Stuver, J. S. Noel, M. Fyffe, O. Matherny, B. Lantz, Susan M. Scott, Teviet Creighton, Herbert Walther, Y. Hefetz, Gerhard Heinzel, C. Hardham, Helena Armandula, E. J. Elliffe, M. V. Plissi, Roman Schnabel, S. Penn, Karsten Kötter, Pamela J. Russell, S. Richman, B. Barr, H. Ward, Chad Hanna, A. Heptonstall, J. Worden, A. Rüdiger, K. Rawlins, Benno Willke, K. D. Zaleski, Oliver Jennrich, Subhasish Mitra, Marco G. Tarallo, X. Siemens, C. Wilkinson, J. Castiglione, D. Barker, K. A. Thorne, Adrian C. Ottewill, P. Charlton, Michael E Zucker, A. Di Credico, D. Churches, L. Ruet, Hartmut Grote, R. Riesen, D. Webber, B. F. Whiting, John Veitch, S. Roddy, Roland Schilling, M. Fine, E. J. Daw, S. Dhurandhar, Krzysztof Belczynski, R. Mittleman, Nelson Christensen, A. Hartunian, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, D. Ugolini, Carsten Fallnich, Stefan Hild, M. A. Barton, I. A. Bilenko, V. Dergachev, Ian Taylor, David J. Ottaway, Alessandra Buonanno, E. Black, Martin M. Fejer, J. R. Smith, S. Klimenko, T. Nash, V. V. Frolov, M. MacInnis, S. Mukherjee, Sanichiro Yoshida, D. Sellers, A. M. Sintes, P. Aufmuth, Jeffrey A. Edlund, F. Nocera, Lee Samuel Finn, J. W C McNabb, D. Jungwirth, A. Sazonov, Manuel Luna, K. Reithmaier, A. Gillespie, Andreas Freise, A. Libson, Matthew Pitkin, A. Ivanov, M. Mageswaran, R. Wooley, R. Burgess, Daniel C. Woods, N. A. Robertson, Richard J. Abbott, I. Yakushin, P. E. Lindquist, H. Radkins, S. P. Vyachanin, M. Coles, M. Guenther, D. I. Robertson, C. Torres, Graham Woan, A. Rodriguez, Robert L. Byer, K. Y. Franzen, E. Maros, Stuart Reid, Curt Cutler, C. Gray, C. A. Cantley, T. Regimbau, Roy Williams, K. Wette, R. Coldwell, W. Tyler, T. Evans, Carlo Ungarelli, Michael D. Smith, Keisuke Goda, David Jones, Guenakh Mitselmakher, C. I. Torrie, C. Barker, V. Parameshwaraiah, K. S. Ganezer, Patrick Brady, Pankaj Sarin, D. Farnham, Raymond G. Beausoleil, A. Ageev, M. Hammond, C. Messenger, M. Lormand, O. Spjeld, R. Zhu, W. Hua, C. Robinson, Benjamin William Allen, K. Watts, B. Bland, V. Chickarmane, I. Zawischa, D. Sigg, W. W. Johnson, S. W. Ballmer, Stefan Goßler, R. Gustafson, Karsten Danzmann, M. C. Sumner, R. Balasubramanian, M. Rakhmanov, V. Schmidt, D. Chin, Stanislav Babak, Walid A. Majid, Erik Katsavounidis, Phil Willems, Gavin Davies, Duncan A. Brown, Walter Winkler, J. Kern, P. G. Murray, D. Steussy, B. Sears, Kevin M. Carter, J. A. Giaime, S. B. Anderson, Jan Harms, William E. Butler, Peter R. Saulson, M. Ito, Martin P McHugh, B. J. Cusack, Brent Ware, Bernard F. Schutz, Eileen S. Rotthoff, Vladimir B. Braginsky, Kevin C. Schlaufman, J. H. Hough, S. E. Seader, B. Bhawal, David B. Tanner, H. Ding, G. Mendell, M. W. Regehr, Marco Aurelio Diaz, M. Sung, S. Grunewald, K. Riles, M. H. P. M. van Putten, S. Tilav, L. Jones, Rana X. Adhikari, Gareth Jones, L. Sievers, Robert Bennett, Thomas Cokelaer, Peter H. Sneddon, G. Stapfer, Gregory M. Harry, Erika D'Ambrosio, Michele Zanolin, C. A. Shapiro, M. Pedraza, Vicky Kalogera, Robert Spero, Soumya D. Mohanty, Harald Lück, U. Weiland, S. R. Rao, M. Lei, T. Olson, M. Barnes, Julien Sylvestre, D. M. Strom, L. Wallace, S. J. Berukoff, R. Bork, N. Zotov, S. Seel, Lisa M. Goggin, K. Mason, R. Frey, A. Marin, C. Aulbert, Scott Koranda, C. Parameswariah, J. Langdale, Sandra E. Wiley, Gabriela Gonzalez, P. J. King, D. Grimmett, I. Leonor, Philip Nutzman, L. Matone, M. Ashley, D. Coyne, A. M. Gretarsson, D. Cook, A. Khan, J. Mason, Virginio Sannibale, David E. McClelland, G. Moreno, Guido Mueller, Yousuke Itoh, B. Bochner, Maria Alessandra Papa, Kent Blackburn, Herbert Welling, Massimo Tinto, Nergis Mavalvala, B. C. Barish, H. Yamamoto, A. Grant, J. Garofoli, Stephen Fairhurst, A. G. Wiseman, S. Wen, Lindy Blackburn, P. Ehrens, Chunglee Kim, V. Sandberg, Michele Vallisneri, A. Sibley, B. Machenschalk, S. Ray-Majumder, Seiji Kawamura, S. Márka, B. Rivera, Philippe Grandclément, K. T. Reilly, David H. Shoemaker, Shantanu Desai, Ik Siong Heng, F. Asiri, Kip S. Thorne, A. J. Weinstein, W. Wu, R. W.P. Drever, F. Mann, Peter Fritschel, Shinji Miyoki, Kenneth A. Strain, A. Weidner, R. A. Mercer, J. Heefner, B. O'Reilly, Reinhard Prix, V. P. Mitrofanov, P. J. Sutton, Haisheng Rong, K. C. Cannon, M. Lubinski, S. E. Whitcomb, M. C. Araya, B. Johnson, W. O. Hamilton, C. N. Colacino, K. Mailand, J. Chapsky, J. Hanson, Osamu Miyakawa, David H. Reitze, S. Killbourn, H. Overmier, James Whelan, Juri Agresti, A. Rizzi, G. Traylor, P. Ajith, L. Zhang, Thomas Corbitt, Christian J. Killow, Akiteru Takamori, Badri Krishnan, Antony C. Searle, T. Findley, S. Liu, D. Ouimette, Yi Chen, J. Cannizzo, J. Allen, D. Kozak, N. Hepler, M. Hennessy, Q. Z. Shu, R. L. Ward, M. Hrynevych, A. Bunkowski, T. Summerscales, Frank Seifert, Joseph M. Kovalik, S. Wise, E. Messaritaki, Sheila Rowan, J. H. Romie, K. Bayer, Michael Landry, S. Meshkov, Kenneth G. Libbrecht, F. J. Raab, S. Chelkowski, R. McCarthy, G. Billingsley, C. Vorvick, P. Schwinberg, J. D. E. Creighton, I. Salzman, R. Amin, W. G. Anderson, Peter Shawhan, M. Tibbits, B. P. Abbott, R. M. S. Schofield, S. Vass, J. Zweizig, Benjamin J. Owen, E. Myers, K. V. Tokmakov, D. Busby, Junwei Cao, R. L. Savage, S. Nagano, D. Redding, M. Malec, P. Hoang, Eugeniy E. Mikhailov, Alberto Vecchio, A. Lazzarini, Richard J. K. Taylor, Gianpietro Cagnoli, J. Myers, Shourov Chatterji, Suvadeep Bose, M. R. Smith, G. H. Sanders, R. Lawrence, M. Hewitson, Morag M. Casey, M. Heurs, B. J. Winjum, A. C. Melissinos, David Crooks, A. Bullington, L. Bogue, D. Rose, R. Desalvo, V. Re, Rainer Weiss, N. Hindman, J. G. Rollins, Jordan Camp, T. Delker, P. R. Williams, J. Dalrymple, A. S. Sengupta, H. Tariq, G. Newton, Matthew Evans, L. Cardenas, Vuk Mandic, Yi Pan, Eric K. Gustafson, T. T. Lyons, J. Logan, R. K. Nayak, R. Rahkola, R. J. Dupuis, and The LIGO Scientific Collaboration
Subjects: Physics, Nuclear and High Energy Physics, Gravitational-wave observatory, 010308 nuclear & particles physics, Gravitational wave, FOS: Physical sciences, Binary number, Astronomy, General Relativity and Quantum Cosmology (gr-qc), Astrophysics, 01 natural sciences, Cosmology, LIGO, General Relativity and Quantum Cosmology, filters, Interferometry, Binary black hole, 0103 physical sciences, Astronomical interferometer, ddc:530, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, FILTERS, 010303 astronomy & astrophysics, QC
Abstract: We report on a search for gravitational waves from binary black hole inspirals in the data from the second science run of the LIGO interferometers. The search focused on binary systems with component masses between 3 and 20 solar masses. Optimally oriented binaries with distances up to 1 Mpc could be detected with efficiency of at least 90%. We found no events that could be identified as gravitational waves in the 385.6 hours of data that we searched., 18 pages, 8 figures
Published: 2006

8. Joint LIGO and TAMA300 Search for Gravitational Waves from Inspiralling Neutron Star Binaries

Author: J. E. Brau, Subhasish Mitra, D. Churches, A. J. Weinstein, W. Wu, P. T. Beyersdorf, A. Grant, S. Liu, L. Zhang, Keisuke Goda, Erik Katsavounidis, Daisuke Tatsumi, A. Wilson, M. J. Lubinski, Vladimir B. Braginsky, K. Riles, Yousuke Itoh, Ken-ichi Nakao, A. Ageev, M. Lormand, M. Fine, K. Rawlins, A. Bunkowski, Kazuyuki Miura, J. Logan, R. K. Nayak, Rebecca Abbott, J. Heefner, Mayu Katsuki, David H. Shoemaker, R. Rahkola, Y. Hefetz, Shigemi Otsuka, Peter Fritschel, Gerhard Heinzel, C. Hardham, Hideki Ishitsuka, Hideki Asada, Jan Harms, Alberto Vecchio, Juri Agresti, A. Rizzi, S. Penn, Benno Willke, L. Ruet, Kazuaki Kuroda, Robert J. McCarthy, Linqing Wen, Pamela J. Russell, S. Richman, K. C. Cannon, A. Bullington, F. Mann, Shuichi Sato, Masaru Shibata, A. Gillespie, Oliver Jennrich, Akitoshi Ueda, L. Bogue, R. L. Savage, V. V. Frolov, Curt Cutler, Alessandra Buonanno, V. Parameshwaraiah, I. Leonor, John K. Cannizzo, T. Summerscales, S. Nagano, Yusaku Hamuro, Darby Kozak, K. A. Thorne, J. Betzwieser, M. C. Araya, D. Ugolini, Mitsuru Musha, Y. Saito, Carsten Fallnich, Yoshikazu Karasawa, R. J. Dupuis, Kiminori Kondo, C. Torres, A. Rodriguez, C. Barker, B. Johnson, Naoki Seto, D. Redding, Youhei Sato, Joseph D. Romano, C. King, Stefan Hild, N. Sato, C. A. Cantley, C. Robinson, Benjamin William Allen, Karsten Danzmann, M. C. Sumner, Shoken M. Miyama, D. Chin, Stanislav Babak, Kasem Mossavi, Walid A. Majid, Duncan A. Brown, P. Hoang, G. Traylor, Thomas Corbitt, Michael Landry, G. Billingsley, Michele Vallisneri, Ik Siong Heng, Fumiko Kawazoe, H. Tariq, Shigenori Moriwaki, J. Chapsky, S. Meshkov, Akiteru Takamori, Pankaj Sarin, D. Farnham, Akito Araya, E. J. Daw, Brent Ware, Y. Ogawa, Norikatsu Mio, G. Mendell, Soma Mukherjee, Sanichiro Yoshida, M. R. Smith, Shinji Miyoki, Graham Woan, Zong Hong Zhu, Robert L. Byer, Stuart Reid, Shihori Sakata, A. M. Gretarsson, D. Rose, C. A. Shapiro, V. Schmidt, Toru Tanji, T. Nakamura, E. Rotthoff, P. Csatorday, William E. Butler, Eugeniy E. Mikhailov, T. Findley, E. Messaritaki, Morag M. Casey, M. Heurs, D. Ouimette, C. Gray, Erika D'Ambrosio, A. Chandler, B. J. Winjum, C. Parameswariah, M. Rakhmanov, Vuk Mandic, Bernard F. Schutz, H. Yamamoto, Takaharu Kaneyama, J. W C McNabb, Laura Cadonati, Walter Winkler, Sheila Rowan, Harald Lück, G. Stapfer, Kevin M. Ryan, J. Hanson, Yoshitaka Nagayama, J. Langdale, G. P. Newton, M. Fyffe, N. A. Robertson, Ken-ichi Ueda, Sandra E. Wiley, Gabriela Gonzalez, Ken'ichi Nakagawa, Martin P McHugh, V. Re, Susan M. Scott, G. H. Sanders, R. Lawrence, M. H. P. M. van Putten, Koichi Waseda, C. Aulbert, S. Tilav, Guido Mueller, Rana X. Adhikari, Gareth Jones, H. Overmier, Roy Williams, J. A. Giaime, Katsuaki Kasahara, Eric K. Gustafson, Hideo Iguchi, Kentaro Somiya, Kenji Soida, B. Machenschalk, P. R. Williams, Takashi Kuwabara, Richard J. K. Taylor, S. Wise, D. Sellers, Teviet Creighton, S. Grunewald, Herbert Walther, Chad Hanna, K. Kötter, C. Wilkinson, Gianpietro Cagnoli, Toshikazu Suzuki, Rainer Weiss, T. Etzel, A. C. Melissinos, K. Oohara, T. T. Lyons, E. Maros, M. V. Plissi, M. Kawamura, Shantanu Desai, Kip S. Thorne, B. Lantz, K. S. Ganezer, Kouichi Sato, Albert Lazzarini, M. Coles, M. Guenther, Tomiyoshi Haruyama, R. W. P. Drever, Kenji Numata, Masaki Ando, K. Watts, Kenneth G. Libbrecht, I. Salzman, Stefan Goßler, Michael D. Smith, Marco G. Tarallo, K. T. Reilly, W. W. Johnson, J. Myers, F. Nocera, J. Allen, N. Hepler, Ryuichi Fujita, W. O. Hamilton, Scott Koranda, D. Webber, V. P. Mitrofanov, R. M. S. Schofield, C. Vorvick, A. Marin, Yoshio Nishi, Shuzo Takemoto, B. Bochner, Akira Okutomi, Hideaki Kudoh, Benjamin J. Owen, P. Schwinberg, V. Quetschke, Shourov Chatterji, W. R. Johnston, Yoshihide Kozai, Bangalore Suryanarayana Sathyaprakash, E. Black, Norihiko Kamikubota, Patrick Brady, Suvadeep Bose, Takayuki Tomaru, Masatake Ohashi, Kevin C. Schlaufman, E. Myers, K. V. Tokmakov, S. Killbourn, Carlo Ungarelli, Martin M. Fejer, Hideyuki Tagoshi, J. R. Smith, R. Bork, T. Regimbau, Toshifumi Futamase, C. I. Torrie, Herbert Welling, A. Heptonstall, M. Malec, T. Nash, W. G. Anderson, Peter Shawhan, M. Tibbits, B. P. Abbott, A. Sazonov, Seiji Kawamura, Nobuyuki Kanda, Hartmut Grote, James Whelan, P. Ajith, L. Matone, Yukiyoshi Iida, Martin Hewitson, Massimo Tinto, Nergis Mavalvala, J. G. Rollins, Junwei Cao, Reinhard Prix, Naoko Ohishi, B. C. Barish, K. D. Zaleski, Phil Willems, M. Hrynevych, R. DeSalvo, S. Vass, W. Kells, P. Ehrens, D. Busby, D. M. Strom, Masa-Katsu Fujimoto, Kevin M. Carter, T. Delker, P. G. Murray, Osamu Miyakawa, David H. Reitze, Christian J. Killow, S. B. Anderson, Hiroyuki Nakano, Misao Sasaki, Jordan Camp, A. Sibley, J. Dalrymple, Masao Tokunari, Lindon J. Robison, A. S. Sengupta, J. H. Hough, D. Jungwirth, Philippe Grandclément, P. E. Lindquist, K. Wette, Peter Aufmuth, David B. Tanner, M. W. Regehr, Lisa M. Goggin, Douglas R. Cook, M. Sung, P. J. Sutton, Haisheng Rong, Timothy Evans, Helena Armandula, E. J. Elliffe, Kazuhiro Hayama, M. Pedraza, Michele Zanolin, S. Seel, R. Coldwell, Jeffrey A. Edlund, M. A. Barton, D. Sigg, Keiko Kokeyama, Gavin Davies, D. Steussy, Koji Arai, R. Burgess, Maria Alessandra Papa, V. Chickarmane, Daniel C. Woods, B. Sears, Kimio Tsubono, T. Akutsu, S. W. Ballmer, Kent Blackburn, S. Wen, D. I. Robertson, Vicky Kalogera, Souichi Telada, J. Mason, B. Bhawal, D.B. DeBra, S. J. Berukoff, K. Y. Franzen, M. Hammond, J. Kern, Hisa-aki Shinkai, L. Jones, Robert Bennett, A. Yamamoto, Matthew Evans, L. Cardenas, Yi Pan, S. Klimenko, Ryutaro Takahashi, Y. Tsunesada, G. Moreno, Robert Spero, Soumya D. Mohanty, David Crooks, N. Zotov, K. Mason, Sanjeev Dhurandhar, S. Ray-Majumder, Xavier Siemens, C. N. Colacino, Yi Chen, M. Hennessy, Q. Z. Shu, R. L. Ward, M. Ito, J. H. Romie, K. Bayer, F. J. Raab, R. Gustafson, S. Márka, Takakazu Shintomi, J. Zweizig, Kohei Takeno, B. Bland, U. Weiland, Takahiro Tanaka, Kenneth A. Strain, S. E. Seader, A. Weidner, R. A. Mercer, Michael E Zucker, Stephen Fairhurst, Tatsuru Yoshida, A. L. Stuver, O. Matherny, Manuel Luna, B. O'Reilly, J. S. Noel, B. Barr, Hiromi Mizusawa, J. Worden, A. Rüdiger, Namio Matsuda, J. Castiglione, Youhei Fujiki, P. Charlton, R. Riesen, A. Di Credico, Roland Schilling, I. A. Bilenko, V. Dergachev, Ian Taylor, David J. Ottaway, Marco Aurelio Diaz, Nobuhiro Tsuda, David Jones, Peter R. Saulson, Taketoshi Kasai, F. Asiri, Badri Krishnan, H. Ding, Takashi Uchiyama, Antony C. Searle, Kunihito Ioka, Frank Seifert, B. F. Whiting, Joseph M. Kovalik, S. E. Whitcomb, I. Yakushin, Hirotaka Takahashi, Keisuke Taniguchi, B. J. Cusack, Guenakh Mitselmakher, S. R. Rao, O. Spjeld, R. Zhu, Toshitaka Yamazaki, M. Ashley, Mitsuhiro Fukushima, L. Sievers, Jolien D. E. Creighton, Thomas Cokelaer, Lindy Blackburn, Yuriko Yanagi, Chunglee Kim, V. Sandberg, D. Barker, A. Ivanov, H. Radkins, S. P. Vyachanin, S. Chelkowski, W. Tyler, S. Roddy, Raymond G. Beausoleil, R. Balasubramanian, A. M. Sintes, Lee Samuel Finn, M. Barnes, Julien Sylvestre, Yoichi Aso, L. Wallace, R. Frey, P. J. King, D. Grimmett, Philip Nutzman, A. G. Wiseman, D. C. Coyne, K. Reithmaier, Andreas Freise, A. Libson, Matthew Pitkin, R. Wooley, I. Zawischa, Peter H. Sneddon, Yasufumi Kojima, J. Garofoli, K. Kawabe, B. Rivera, M. Mageswaran, H. Ward, John Veitch, Jun'ichi Yokoyama, M. MacInnis, R. S. Amin, Kazuhiro Yamamoto, N. Hindman, Gregory M. Harry, M. Lei, T. Olson, A. Khan, Virginio Sannibale, David E. McClelland, C. Messenger, W. Hua, Aya Sekido, Adrian C. Ottewill, K. Mailand, Krzysztof Belczynski, R. Mittleman, Nelson Christensen, A. Hartunian, Roman Schnabel, The LIGO Scientific Collaboration, and TAMA Collaboration
Subjects: Nuclear and High Energy Physics, templates, Milky Way, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Astrophysics, 01 natural sciences, coalescence rates, neutron stars, Cosmology, General Relativity and Quantum Cosmology, binary stars, gravitational wave detectors, 0103 physical sciences, Binary star, ddc:530, compact binaries, 010306 general physics, QC, Astrophysics::Galaxy Astrophysics, Physics, 010308 nuclear & particles physics, Gravitational wave, Astronomy, LIGO, Galaxy, Neutron star, Stars, gravitational waves, light interferometry, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
Abstract: We search for coincident gravitational wave signals from inspiralling neutron star binaries using LIGO and TAMA300 data taken during early 2003. Using a simple trigger exchange method, we perform an inter-collaboration coincidence search during times when TAMA300 and only one of the LIGO sites were operational. We find no evidence of any gravitational wave signals. We place an observational upper limit on the rate of binary neutron star coalescence with component masses between 1 and 3 M_sun of 49 per year per Milky Way equivalent galaxy at a 90% confidence level. The methods developed during this search will find application in future network inspiral analyses., 9 pages, 5 figures. Updated with published version
Published: 2005

9. Search for gravitational waves from primordial black hole binary coalescences in the galactic halo

Author: Laura Cadonati, B. F. Whiting, P. G. Murray, D. Rose, H. Overmier, Susan M. Scott, Teviet Creighton, Herbert Walther, J. H. Hough, X. Siemens, K. Kötter, C. Wilkinson, M. Coles, M. Guenther, A. Rizzi, V. Re, J. Heefner, Douglas R. Cook, L. Jones, Roman Schnabel, J. E. Brau, B. Bland, U. Weiland, Michele Zanolin, Patrick Brady, S. Seel, Rainer Weiss, R. W. P. Drever, O. Matherny, S. E. Seader, F. Nocera, B. Barr, J. Worden, A. Rüdiger, R. Riesen, D. Churches, Roland Schilling, Richard J. K. Taylor, Gianpietro Cagnoli, T. Summerscales, M. A. Barton, W. W. Johnson, C. A. Shapiro, Stephen Fairhurst, J. H. Romie, K. Bayer, F. J. Raab, F. Asiri, S. E. Whitcomb, Michael Landry, T. Findley, D. Ouimette, A. M. Gretarsson, Philippe Grandclément, P. J. Sutton, Haisheng Rong, Michele Vallisneri, R. Gustafson, D.B. DeBra, K. Rawlins, A. Bunkowski, T. Regimbau, A. Wilson, H. Ward, C. I. Torrie, A. Heptonstall, M. Malec, D. Steussy, B. Sears, K. Y. Franzen, Jordan Camp, Ik Siong Heng, Vicky Kalogera, E. Messaritaki, G. Billingsley, M. Hammond, J. Myers, Phil Willems, M. W.E. Smith, J. Kern, A. S. Sengupta, Y. Hefetz, G. Mendell, Scott Koranda, L. Matone, S. Wise, S. Chatterji, Sheila Rowan, R. J. Dupuis, Suvadeep Bose, D. M. Strom, S. Grunewald, B. Lantz, John Veitch, Gerhard Heinzel, C. Hardham, Benno Willke, A. Sibley, Richard S. Savage, J. Mason, J. Zweizig, K. D. Zaleski, David Jones, R. DeSalvo, N. A. Robertson, Kenneth G. Libbrecht, I. Salzman, D. B. Kozak, C. Vorvick, Seiji Kawamura, Reinhard Prix, A. J. Weinstein, W. Wu, Matthew Evans, L. Cardenas, A. Gillespie, C. Parameswariah, R. M. S. Schofield, Alberto Vecchio, Yi Pan, M. MacInnis, Osamu Miyakawa, C. A. Cantley, David H. Reitze, Benjamin J. Owen, Peter R. Saulson, Shinji Miyoki, Christian J. Killow, K. Reithmaier, Andreas Freise, A. Libson, Matthew Pitkin, Alessandra Buonanno, Benjamin William Allen, S. Klimenko, R. Abbott, J. Langdale, G. P. Newton, M. Fyffe, W. G. Anderson, K. V. Tokmakov, S. Penn, Robert Spero, Soumya D. Mohanty, A. Ageev, C. Aulbert, Peter Shawhan, M. Tibbits, B. P. Abbott, Sandra E. Wiley, Gabriela Gonzalez, H. Tariq, Pamela J. Russell, S. Richman, Oliver Jennrich, Karsten Danzmann, M. C. Sumner, M. Lormand, M. Fine, S. Vass, Martin Hewitson, R. Wooley, N. Zotov, K. Mason, Jan Harms, A. Grant, S. Liu, K. A. Thorne, J. Betzwieser, Peter Fritschel, D. Ugolini, Carsten Fallnich, Jeffrey A. Edlund, Sanichiro Yoshida, W. Kells, D. Busby, Carlo Ungarelli, J. S. Noel, M. Ito, Graham Woan, Sanjeev Dhurandhar, S. Ray-Majumder, Robert L. Byer, Stuart Reid, Stefan Hild, R. Burgess, A. Bullington, Daniel C. Woods, Erika D'Ambrosio, S. Nagano, C. Torres, Soma Mukherjee, M. Rakhmanov, C. N. Colacino, Bernard F. Schutz, D. Redding, Keisuke Goda, M. R. Smith, M. Hrynevych, L. Bogue, D. I. Robertson, G. Stapfer, V. V. Frolov, J. Castiglione, P. Hoang, C. Barker, I. Zawischa, J. Hanson, Guido Mueller, P. Charlton, Erik Katsavounidis, I. Leonor, V. Parameshwaraiah, A. Di Credico, Yi Chen, H. Yamamoto, M. Hennessy, Q. Z. Shu, Roy Williams, M. J. Lubinski, S. Meshkov, G. Traylor, Thomas Corbitt, Akiteru Takamori, D. Barker, Walter Winkler, Harald Lück, Kip S. Thorne, D. Chin, I. A. Bilenko, V. Dergachev, Ian Taylor, David J. Ottaway, S. Wen, D. Farnham, E. J. Daw, Stanislav Babak, Walid A. Majid, K. S. Ganezer, K. Watts, Vladimir B. Braginsky, Curt Cutler, G. H. Sanders, R. Lawrence, K. Riles, Duncan A. Brown, Stefan Goßler, V. Schmidt, S. Chelkowski, David H. Shoemaker, V. P. Mitrofanov, N. Hepler, K. T. Reilly, R. Bennett, William E. Butler, R. Amin, Brent Ware, M. C. Araya, W. O. Hamilton, A. Marin, Yousuke Itoh, F. Mann, Kevin C. Schlaufman, T. Etzel, Herbert Welling, Nergis Mavalvala, P. Ehrens, J. W C McNabb, B. Bochner, A. Stuver, S. Roddy, Martin P McHugh, M. H. P. M. van Putten, S. Killbourn, S. Tilav, B. C. Barish, Massimo Tinto, E. Rotthoff, Kevin M. Carter, B. Johnson, James Whelan, S. B. Anderson, P. Schwinberg, J. Chapsky, D. Webber, E. Maros, H. Ding, L. Zhang, Rana X. Adhikari, B. Machenschalk, V. Quetschke, David B. Tanner, Bangalore Suryanarayana Sathyaprakash, E. Black, M. W. Regehr, Martin M. Fejer, J. R. Smith, R. Bork, T. Nash, C. Gray, Peter H. Sneddon, A. Sazonov, M. Pedraza, Maria Alessandra Papa, Kent Blackburn, A. M. Sintes, J. Garofoli, Lee Samuel Finn, Robert J. McCarthy, K. Kawabe, B. Rivera, I. Yakushin, Linqing Wen, M. Mageswaran, Guenakh Mitselmakher, J. A. Giaime, Eric K. Gustafson, R. Zhu, L. Sievers, Thomas Cokelaer, M. Barnes, Julien Sylvestre, Timothy Evans, T. T. Lyons, L. Wallace, R. Frey, P. J. King, D. Grimmett, Philip Nutzman, A. G. Wiseman, R. Coldwell, D. C. Coyne, Albert Lazzarini, D. Sigg, S. W. Ballmer, Joseph D. Romano, C. King, G. Moreno, Kasem Mossavi, J. G. Rollins, A. Ivanov, W. R. Johnston, David Crooks, P. Csatorday, T. Delker, P. R. Williams, J. Logan, R. K. Nayak, M. V. Plissi, R. Rahkola, Lindon J. Robison, H. Radkins, Michael E Zucker, Helena Armandula, E. J. Elliffe, Hartmut Grote, A. Chandler, S. P. Vyachanin, Kevin M. Ryan, W. Tyler, D. Jungwirth, N. Hindman, P. E. Lindquist, Peter Aufmuth, Marco Aurelio Diaz, A. Parameswaran, V. Chickarmane, Raymond G. Beausoleil, B. Bhawal, R. Balasubramanian, S. J. Berukoff, Badri Krishnan, S. Márka, Antony C. Searle, Kenneth A. Strain, A. Weidner, R. A. Mercer, B. O'Reilly, Frank Seifert, Joseph M. Kovalik, C. Messenger, Morag M. Casey, M. Heurs, B. J. Winjum, W. Hua, B. J. Cusack, S. R. Rao, M. Ashley, Gregory M. Harry, M. Lei, T. Olson, Jolien D. E. Creighton, Lindy Blackburn, Chunglee Kim, A. Khan, V. Sandberg, Virginio Sannibale, David E. McClelland, Adrian C. Ottewill, K. Mailand, Krzysztof Belczynski, R. Mittleman, Nelson Christensen, A. Hartunian, and The LIGO Scientific Collaboration
Subjects: Nuclear and High Energy Physics, MACHO PROJECT, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Primordial black hole, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, General Relativity and Quantum Cosmology, Galactic halo, Binary black hole, 0103 physical sciences, 10. No inequality, 010303 astronomy & astrophysics, QC, Astrophysics::Galaxy Astrophysics, Physics, 010308 nuclear & particles physics, Gravitational wave, Astronomy, LIGO, Black hole, Intermediate-mass black hole, Stellar black hole
Abstract: We use data from the second science run of the LIGO gravitational-wave detectors to search for the gravitational waves from primordial black hole (PBH) binary coalescence with component masses in the range 0.2--$1.0 M_\odot$. The analysis requires a signal to be found in the data from both LIGO observatories, according to a set of coincidence criteria. No inspiral signals were found. Assuming a spherical halo with core radius 5 kpc extending to 50 kpc containing non-spinning black holes with masses in the range 0.2--$1.0 M_\odot$, we place an observational upper limit on the rate of PBH coalescence of 63 per year per Milky Way halo (MWH) with 90% confidence., Comment: 7 pages, 4 figures, to be submitted to Phys. Rev. D
Published: 2005

10. Search for gravitational waves from galactic and extra-galactic binary neutron stars

Author: Sanichiro Yoshida, B. F. Whiting, Graham Woan, Robert L. Byer, E. Maros, Stuart Reid, M. Rakhmanov, U. Weiland, E. J. Daw, C. Parameswariah, M. Coles, M. Guenther, Bernard F. Schutz, G. Stapfer, J. Langdale, Sandra E. Wiley, Michael D. Smith, Gabriela Gonzalez, Guido Mueller, J. W C McNabb, David Jones, Patrick Brady, A. Wilson, K. D. Zaleski, Roman Schnabel, D. Churches, Peter R. Saulson, D. Steussy, B. Sears, H. Yamamoto, N. A. Robertson, H. Ding, Vicky Kalogera, A. Rizzi, J. Mason, Alberto Vecchio, J. E. Brau, W. R. Johnston, F. Asiri, S. E. Whitcomb, C. Gray, M. Ito, P. Schwinberg, D. Webber, Carlo Ungarelli, Seiji Kawamura, Reinhard Prix, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, E. Black, Martin M. Fejer, A. Gillespie, J. S. Noel, T. Summerscales, J. R. Smith, S. Klimenko, T. Nash, C. A. Shapiro, Osamu Miyakawa, David H. Reitze, J. Hanson, Y. Hefetz, Gerhard Heinzel, C. Hardham, A. Sazonov, Lindon J. Robison, Benno Willke, Christian J. Killow, D. Rose, R. Desalvo, D. Kozak, W. O. Hamilton, Philippe Grandclément, P. J. Sutton, Kevin M. Carter, Haisheng Rong, C. Aulbert, Scott Koranda, L. Matone, C. A. Cantley, S. Killbourn, J. Castiglione, H. Overmier, P. Charlton, Michael Landry, Helena Armandula, E. J. Elliffe, Benjamin William Allen, R. McCarthy, Karsten Danzmann, M. C. Sumner, A. Ivanov, A. Di Credico, S. B. Anderson, David B. Tanner, James Whelan, L. Zhang, Alessandra Buonanno, Curt Cutler, G. Mendell, M. W. Regehr, V. Re, J. H. Romie, K. Bayer, I. A. Bilenko, S. Nagano, V. Dergachev, Ian Taylor, David J. Ottaway, F. J. Raab, V. Parameshwaraiah, G. Billingsley, H. Radkins, Linqing Wen, S. P. Vyachanin, O. Matherny, M. Pedraza, W. Tyler, B. Lantz, Rainer Weiss, A. Sibley, Maria Alessandra Papa, B. Barr, Shinji Miyoki, S. Chatterji, D. Chin, Peter Fritschel, P. G. Murray, J. Worden, J. A. Giaime, Stanislav Babak, Walid A. Majid, Erika D'Ambrosio, T. Etzel, A. Rüdiger, Duncan A. Brown, D. Redding, M. Malec, P. Hoang, S. Penn, J. H. Hough, Kent Blackburn, Karsten Kötter, Jordan Camp, Pamela J. Russell, S. Richman, Raymond G. Beausoleil, J. D. E. Creighton, I. Salzman, Joseph D. Romano, C. King, R. Balasubramanian, Oliver Jennrich, R. Riesen, J. Zweizig, L. Jones, Michele Zanolin, M. Hrynevych, S. Seel, Roland Schilling, Kasem Mossavi, R. Amin, R. M. S. Schofield, Brent Ware, M. Lubinski, A. S. Sengupta, E. Rotthoff, G. Newton, M. Ashley, K. A. Thorne, M. R. Smith, D. Ugolini, Carsten Fallnich, Stefan Hild, K. Mailand, Kip S. Thorne, R. W.P. Drever, Richard J. Abbott, Benjamin J. Owen, Rana X. Adhikari, Robert Spero, Soumya D. Mohanty, Matthew Evans, L. Cardenas, T. Findley, K. V. Tokmakov, D. Debra, N. Zotov, A. Chandler, D. Coyne, B. Bland, A. M. Gretarsson, V. P. Mitrofanov, M. C. Araya, K. Mason, T. Evans, Yi Pan, Kevin M. Ryan, B. Machenschalk, S. Ray-Majumder, S. E. Seader, A. Heptonstall, D. Cook, D. Ouimette, G. H. Sanders, R. Lawrence, M. Fine, Walter Winkler, Harald Lück, C. N. Colacino, J. Betzwieser, Lindy Blackburn, P. Ehrens, Stephen Fairhurst, A. Lazzarini, Richard J. K. Taylor, Gianpietro Cagnoli, Yi Chen, A. Bullington, M. Hennessy, Q. Z. Shu, L. Bogue, M. A. Barton, Chunglee Kim, G. Traylor, Thomas Corbitt, S. Wise, J. Myers, A. Marin, Akiteru Takamori, V. Sandberg, Suvadeep Bose, K. Y. Franzen, M. Hammond, B. Bochner, E. Messaritaki, Massimo Tinto, Sheila Rowan, S. Meshkov, Kenneth G. Libbrecht, S. Chelkowski, J. Kern, Robert Bennett, Laura Cadonati, K. Kawabe, C. Vorvick, W. Kells, B. J. Cusack, W. G. Anderson, Peter Shawhan, M. Tibbits, B. P. Abbott, T. T. Lyons, S. Vass, Susan M. Scott, Teviet Creighton, Herbert Walther, D. Busby, N. Hepler, X. Siemens, C. Wilkinson, S. R. Rao, A. Bunkowski, A. Ageev, F. Nocera, Jan Harms, G. Moreno, T. Regimbau, C. I. Torrie, Phil Willems, D. M. Strom, A. J. Weinstein, W. Wu, S. Liu, Keisuke Goda, Erik Katsavounidis, Adrian C. Ottewill, Vladimir B. Braginsky, K. Riles, Yousuke Itoh, Krzysztof Belczynski, David Crooks, R. Mittleman, Nelson Christensen, A. Hartunian, N. Hindman, S. Mukherjee, R. Coldwell, D. Sigg, W. W. Johnson, S. W. Ballmer, M. Hewitson, Morag M. Casey, M. Heurs, B. J. Winjum, I. Yakushin, C. Messenger, Guenakh Mitselmakher, M. Lormand, R. Zhu, L. Sievers, W. Hua, Thomas Cokelaer, D. Barker, S. Roddy, Gregory M. Harry, M. Lei, T. Olson, A. M. Sintes, A. Khan, P. Aufmuth, Lee Samuel Finn, Virginio Sannibale, David E. McClelland, M. Barnes, Julien Sylvestre, L. Wallace, R. Frey, P. J. King, D. Grimmett, I. Leonor, Philip Nutzman, A. G. Wiseman, S. Grunewald, J. Logan, R. K. Nayak, R. Rahkola, S. Wen, David H. Shoemaker, K. Reithmaier, F. Mann, J. Heefner, A. Stuver, Andreas Freise, A. Libson, Matthew Pitkin, B. Johnson, J. Chapsky, J. G. Rollins, S. Dhurandhar, M. Mageswaran, R. Wooley, T. Delker, P. R. Williams, H. Tariq, Eric K. Gustafson, I. Zawischa, Badri Krishnan, Antony C. Searle, V. Chickarmane, Frank Seifert, Joseph M. Kovalik, H. Ward, B. Bhawal, Michael E Zucker, S. J. Berukoff, R. Bork, John Veitch, Marco Aurelio Diaz, P. Csatorday, V. V. Frolov, M. MacInnis, A. Parameswaran, M. Fyffe, M. V. Plissi, Peter H. Sneddon, J. Garofoli, Hartmut Grote, K. Rawlins, D. Jungwirth, P. E. Lindquist, S. Márka, Kenneth A. Strain, A. Weidner, R. A. Mercer, C. Torres, B. O'Reilly, C. Barker, B. Rivera, D. Farnham, V. Schmidt, William E. Butler, Martin P McHugh, M. H. P. M. van Putten, S. Tilav, Richard L. Savage, Jeffrey A. Edlund, R. Burgess, Daniel C. Woods, D. I. Robertson, Roy Williams, K. S. Ganezer, K. Watts, Stefan Goßler, R. Gustafson, K. T. Reilly, Kevin C. Schlaufman, Herbert Welling, Nergis Mavalvala, B. C. Barish, A. Grant, Michele Vallisneri, Ik Siong Heng, R. J. Dupuis, and The LIGO Scientific Collaboration
Subjects: Nuclear and High Energy Physics, templates, Andromeda Galaxy, Milky Way, X-ray binary, FOS: Physical sciences, rates, General Relativity and Quantum Cosmology (gr-qc), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, FORMS, 01 natural sciences, General Relativity and Quantum Cosmology, EVENTS, SYSTEMS, 0103 physical sciences, Binary star, DETECTORS, ddc:530, TEMPLATES, RATES, LIGO, 010303 astronomy & astrophysics, QC, Astrophysics::Galaxy Astrophysics, detectors, Physics, inspiraling compact binaries, 010308 nuclear & particles physics, Gravitational wave, Astronomy, Local Group, ligo, PULSARS, Galaxy, pulsars, INSPIRALING COMPACT BINARIES, systems, forms, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, events
Abstract: We use 373 hours ($\approx$ 15 days) of data from the second science run of the LIGO gravitational-wave detectors to search for signals from binary neutron star coalescences within a maximum distance of about 1.5 Mpc, a volume of space which includes the Andromeda Galaxy and other galaxies of the Local Group of galaxies. This analysis requires a signal to be found in data from detectors at the two LIGO sites, according to a set of coincidence criteria. The background (accidental coincidence rate) is determined from the data and is used to judge the significance of event candidates. No inspiral gravitational wave events were identified in our search. Using a population model which includes the Local Group, we establish an upper limit of less than 47 inspiral events per year per Milky Way equivalent galaxy with 90% confidence for non-spinning binary neutron star systems with component masses between 1 and 3 $M_\odot$., 20 pages, 12 figures, to be submitted to Phys. Rev. D
Published: 2005
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11. Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report

Author: A KLION, B BOCHNER, G GLEICH, T NUTMAN, M ROTHENBERG, H SIMON, M WECHSLER, P WELLER, and null THEHYPEREOSINOPHILICSYNDROMESW
Subjects: medicine.medical_specialty, Vascular disease, Hypereosinophilic syndrome, business.industry, Immunology, MEDLINE, medicine.disease, Gastrointestinal disease, Immunopathology, Hypereosinophilic Syndrome, medicine, Disease Progression, Immunology and Allergy, Eosinophilia, Humans, medicine.symptom, Eosinophilic esophagitis, Intensive care medicine, business, Biomarkers, Anti-neutrophil cytoplasmic antibody
Abstract: Hypereosinophilic syndromes are a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia, tissue eosinophilia, or both, resulting in a wide variety of clinical manifestations. Although corticosteroids are the first-line therapy for many of these disorders, approaches to the treatment of patients who do not tolerate or are unresponsive to corticosteroids are poorly standardized. A multidisciplinary group of 37 clinicians and scientists participated in a workshop held in May 2005 in Bern, Switzerland to discuss current and future approaches to therapy for 3 eosinophil-mediated disorders: hypereosinophilic syndrome, Churg-Strauss syndrome, and eosinophil-associated gastrointestinal disease. The goal of the workshop was to summarize available data regarding treatment of these disorders to identify the most promising therapies and approaches for further study. There was consensus among all of the participants that the identification of markers of disease progression to assess treatment responses is a research priority for all 3 disorders. Furthermore, the need for newer therapeutic strategies and novel drugs, as well as multicenter trials to assess all treatment modalities, was emphasized.
Published: 2005

12. Upper limits on gravitational wave bursts in LIGO's second science run

Author: J. Logan, R. K. Nayak, R. Rahkola, I. Yakushin, Michael E Zucker, R. J. Dupuis, Guenakh Mitselmakher, Manuel Luna, Curt Cutler, Marco Aurelio Diaz, O. Spjeld, R. Zhu, M. C. Araya, A. Wilson, H. Ward, Roy Williams, Y. Hefetz, Gerhard Heinzel, C. Hardham, Benno Willke, T. Findley, Peter Fritschel, D. Ouimette, A. J. Weinstein, W. Wu, Amber Stuver, Sanichiro Yoshida, Graham Woan, Robert L. Byer, Stuart Reid, A. M. Gretarsson, M. Rakhmanov, R. L. Ward, E. Messaritaki, Badri Krishnan, Antony C. Searle, Frank Seifert, Joseph M. Kovalik, K. S. Ganezer, K. Watts, L. Ruet, Albert Lazzarini, E. Rotthoff, Bernard F. Schutz, G. Stapfer, J. Hanson, J. H. Romie, K. C. Cannon, K. Bayer, Sheila Rowan, Stefan Goßler, K. T. Reilly, Seiji Kawamura, Reinhard Prix, Alessandra Buonanno, L. Sievers, John Veitch, Guido Mueller, Morag M. Casey, M. Heurs, Robert J. McCarthy, M. Ito, Shinji Miyoki, B. J. Winjum, S. Wise, S. Grunewald, J. G. Rollins, Thomas Cokelaer, Rana X. Adhikari, Gareth Jones, A. Gillespie, T. Delker, Linqing Wen, Juri Agresti, A. Rizzi, R. Gustafson, B. Machenschalk, Osamu Miyakawa, David H. Reitze, Kevin C. Schlaufman, Kevin M. Carter, A. Grant, S. Liu, M. MacInnis, Herbert Welling, Nergis Mavalvala, C. Aulbert, R. S. Amin, S. Márka, A. Ageev, H. Tariq, T. Summerscales, Christian J. Killow, C. A. Cantley, Pankaj Sarin, A. C. Melissinos, Peter H. Sneddon, Kenneth G. Libbrecht, L. Zhang, Kenneth A. Strain, D. Farnham, Philippe Grandclément, Jan Harms, V. V. Frolov, B. C. Barish, J. Zweizig, V. Parameshwaraiah, Keisuke Goda, C. Robinson, A. Weidner, Benjamin William Allen, Michael Landry, P. J. Sutton, D. Barker, R. A. Mercer, Karsten Danzmann, M. C. Sumner, M. R. Smith, C. A. Shapiro, Adrian C. Ottewill, Joseph D. Romano, C. King, Kasem Mossavi, G. Billingsley, Haisheng Rong, G. Traylor, S. B. Anderson, K. D. Zaleski, R. DeSalvo, David B. Tanner, B. O'Reilly, S. Chelkowski, B. Lantz, Vuk Mandic, Erik Katsavounidis, S. Nagano, J. Garofoli, V. Schmidt, Peter Aufmuth, I. Salzman, K. Mailand, Robert Spero, Soumya D. Mohanty, N. Zotov, K. Mason, S. Roddy, D. Redding, V. Chickarmane, R. M. S. Schofield, Soma Mukherjee, Benjamin J. Owen, J. A. Giaime, Eric K. Gustafson, M. W. Regehr, P. Ehrens, Krzysztof Belczynski, B. F. Whiting, R. Mittleman, Scott Koranda, L. Matone, Sanjeev Dhurandhar, M. J. Lubinski, Thomas Corbitt, S. Meshkov, P. Hoang, Akiteru Takamori, S. Ray-Majumder, M. Sung, Richard L. Savage, R. Bennett, William E. Butler, E. Myers, K. V. Tokmakov, Erika D'Ambrosio, T. T. Lyons, A. Chandler, Nelson Christensen, B. Bhawal, M. Pedraza, K. Wette, A. Hartunian, H. Overmier, D. Chin, Stanislav Babak, Walid A. Majid, C. N. Colacino, Duncan A. Brown, Kevin M. Ryan, A. M. Sintes, Lee Samuel Finn, Vladimir B. Braginsky, Timothy Evans, P. G. Murray, K. Riles, Jeffrey A. Edlund, S. J. Berukoff, K. Kawabe, R. Coldwell, D. Sellers, A. Sibley, Yi Chen, Eugeniy E. Mikhailov, D. B. Kozak, M. Hennessy, Q. Z. Shu, Maria Alessandra Papa, B. Rivera, M. Hrynevych, C. Vorvick, Martin P McHugh, T. Regimbau, C. I. Torrie, A. Heptonstall, D. Sigg, S. W. Ballmer, M. Barnes, Julien Sylvestre, R. Burgess, Daniel C. Woods, M. Mageswaran, J. H. Hough, J. Allen, P. Csatorday, N. Hepler, D. I. Robertson, G. Moreno, W. G. Anderson, M. V. Plissi, Kent Blackburn, K. Reithmaier, L. Wallace, Andreas Freise, I. Leonor, John K. Cannizzo, R. Frey, Shantanu Desai, M. H. P. M. van Putten, A. Libson, S. Tilav, Peter Shawhan, J. Heefner, M. Tibbits, B. P. Abbott, Kip S. Thorne, S. Vass, Douglas R. Cook, David Crooks, Michele Zanolin, S. Seel, M. Coles, Hartmut Grote, M. Guenther, Matthew Pitkin, R. Wooley, P. J. King, D. Grimmett, Philip Nutzman, M. Malec, W. R. Johnston, Phil Willems, W. Kells, M. A. Barton, D. Busby, Brent Ware, Yousuke Itoh, E. Maros, A. G. Wiseman, D. Jungwirth, P. E. Lindquist, E. J. Daw, D. C. Coyne, D.B. DeBra, Michele Vallisneri, V. P. Mitrofanov, I. Zawischa, D. M. Strom, K. Rawlins, Ik Siong Heng, Patrick Brady, Roman Schnabel, N. Hindman, K. Y. Franzen, J. E. Brau, M. Hammond, Walter Winkler, C. Messenger, Subhasish Mitra, Lindon J. Robison, Harald Lück, Helena Armandula, E. J. Elliffe, T. Etzel, A. Bunkowski, W. Hua, M. W.E. Smith, J. Kern, H. Yamamoto, P. R. Williams, Lisa M. Goggin, D. Churches, N. A. Robertson, Gavin Davies, D. Steussy, B. Sears, L. Jones, S. Wen, Laura Cadonati, Vicky Kalogera, Susan M. Scott, Teviet Creighton, Herbert Walther, Gregory M. Harry, F. Raab, A. Marin, M. Lei, X. Siemens, K. Kötter, C. Wilkinson, J. Mason, T. Olson, B. Bochner, David H. Shoemaker, G. H. Sanders, R. Lawrence, P. Schwinberg, F. Nocera, Martin Hewitson, A. Khan, Jordan Camp, Massimo Tinto, Carlo Ungarelli, W. O. Hamilton, J. Dalrymple, D. Webber, Virginio Sannibale, David E. McClelland, S. Penn, S. Killbourn, A. S. Sengupta, Pamela J. Russell, S. Richman, V. Quetschke, James Whelan, F. Mann, C. Torres, Oliver Jennrich, P. Ajith, H. Ding, K. A. Thorne, J. Betzwieser, Bangalore Suryanarayana Sathyaprakash, E. Black, Martin M. Fejer, D. Ugolini, Carsten Fallnich, A. Rodriguez, C. Barker, Stefan Hild, J. R. Smith, R. Bork, T. Nash, Matthew Evans, L. Cardenas, Yi Pan, S. Klimenko, B. Johnson, B. J. Cusack, M. Lormand, M. Fine, A. Sazonov, G. Mendell, Richard J. K. Taylor, S. R. Rao, A. Bullington, C. Parameswariah, L. Bogue, J. Chapsky, J. Langdale, G. P. Newton, M. Fyffe, Sandra E. Wiley, Gabriela Gonzalez, M. Ashley, C. Gray, Gianpietro Cagnoli, D. Rose, V. Re, Jolien D. E. Creighton, Lindy Blackburn, Chunglee Kim, V. Sandberg, Rainer Weiss, R. W. P. Drever, W. W. Johnson, A. Ivanov, H. Radkins, S. P. Vyachanin, W. Tyler, Raymond G. Beausoleil, R. Balasubramanian, J. Myers, Shourov Chatterji, Suvadeep Bose, Alberto Vecchio, J. S. Noel, J. Castiglione, P. Charlton, A. Di Credico, I. A. Bilenko, V. Dergachev, Ian Taylor, David J. Ottaway, David Jones, Peter R. Saulson, R. Abbott, B. Bland, U. Weiland, S. E. Seader, Stephen Fairhurst, O. Matherny, B. Barr, J. Worden, A. Rüdiger, R. Riesen, Roland Schilling, F. Asiri, S. E. Whitcomb, and The LIGO Scientific Collaboration
Subjects: Nuclear and High Energy Physics, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, rotational core collapse, General Relativity and Quantum Cosmology, Constant false alarm rate, 0103 physical sciences, DETECTORS, Waveform, ddc:530, ALGORITHM, 010306 general physics, QC, detectors, Physics, algorithm, 010308 nuclear & particles physics, Gravitational wave, Detector, PERFORMANCE, Noise floor, LIGO, SIGNAL, Amplitude, ROTATIONAL CORE COLLAPSE, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, signal, Noise (radio), performance
Abstract: We perform a search for gravitational wave bursts using data from the second science run of the LIGO detectors, using a method based on a wavelet time-frequency decomposition. This search is sensitive to bursts of duration much less than a second and with frequency content in the 100-1100Hz range. It features significant improvements in the instrument sensitivity and in the analysis pipeline with respect to the burst search previously reported by LIGO. Improvements in the search method allow exploring weaker signals, relative to the detector noise floor, while maintaining a low false alarm rate, O(0.1) microHz. The sensitivity in terms of the root-sum-square (rss) strain amplitude lies in the range of hrss~10^{-20} - 10^{-19}/sqrt(Hz) No gravitational wave signals were detected in 9.98 days of analyzed data. We interpret the search result in terms of a frequentist upper limit on the rate of detectable gravitational wave bursts at the level of 0.26 events per day at 90% confidence level. We combine this limit with measurements of the detection efficiency for given waveform morphologies in order to yield rate versus strength exclusion curves as well as to establish order-of-magnitude distance sensitivity to certain modeled astrophysical sources. Both the rate upper limit and its applicability to signal strengths improve our previously reported limits and reflect the most sensitive broad-band search for untriggered and unmodeled gravitational wave bursts to date., 23 pages, 14 figures, to be submitted to Phys Rev D
Published: 2005

13. Search for gravitational waves associated with the gamma ray burst GRB030329 using the LIGO detectors

Author: J. E. Brau, W. R. Johnston, S. Nagano, D. Ouimette, Sanichiro Yoshida, D. Redding, Graham Woan, Robert L. Byer, Stuart Reid, D. Jungwirth, Philippe Grandclément, P. J. Sutton, P. Hoang, Haisheng Rong, Jordan Camp, Lindon J. Robison, C. Messenger, M. Rakhmanov, Peter H. Sneddon, Bernard F. Schutz, G. Stapfer, A. S. Sengupta, Helena Armandula, J. Hanson, G. Newton, Alberto Vecchio, E. J. Elliffe, W. Hua, David H. Shoemaker, Guido Mueller, R. Amin, Darby Kozak, Michael E Zucker, F. Mann, J. Garofoli, B. Johnson, Morag M. Casey, M. Heurs, Marco Aurelio Diaz, Matthew Evans, L. Cardenas, Yi Pan, Albert Lazzarini, J. H. Romie, K. Bayer, T. Findley, Kevin M. Carter, B. J. Winjum, Walter Winkler, J. Chapsky, Shinji Miyoki, Daniel Sigg, F. J. Raab, S. Klimenko, R. Gustafson, A. Chandler, S. B. Anderson, Harald Lück, P. R. Williams, G. Mendell, Kevin M. Ryan, P. Csatorday, Badri Krishnan, Antony C. Searle, Frank Seifert, David B. Tanner, Joseph M. Kovalik, David Jones, J. Cannizzo, Roman Schnabel, D. Farnham, M. W. Regehr, N. Hepler, J. Betzwieser, A. Rizzi, S. Wise, S. Grunewald, M. V. Plissi, A. Marin, J. G. Rollins, S. Chatterji, C. Parameswariah, C. Gray, V. Schmidt, T. Regimbau, T. Summerscales, Peter R. Saulson, William E. Butler, C. I. Torrie, A. Heptonstall, Kenneth G. Libbrecht, M. Malec, A. Ageev, M. Pedraza, J. Langdale, H. Ding, M. Fyffe, T. Delker, David Crooks, K. Kawabe, B. Rivera, B. Bland, D. Churches, J. Zweizig, Jan Harms, M. Ito, Hartmut Grote, M. Lormand, Sandra E. Wiley, M. Fine, C. Vorvick, Gabriela Gonzalez, Maria Alessandra Papa, Massimo Tinto, U. Weiland, M. Mageswaran, Phil Willems, J. Logan, R. K. Nayak, C. A. Shapiro, G. Billingsley, R. Rahkola, Martin P McHugh, M. H. P. M. van Putten, S. Tilav, Richard J. K. Taylor, Gianpietro Cagnoli, A. Bullington, Linqing Wen, S. Penn, M. Hrynevych, Pamela J. Russell, S. Richman, Kent Blackburn, B. Lantz, P. E. Lindquist, L. Bogue, S. Meshkov, S. E. Seader, I. Salzman, W. G. Anderson, T. Etzel, A. L. Stuver, J. S. Noel, Oliver Jennrich, Peter Shawhan, M. Tibbits, B. P. Abbott, K. A. Thorne, Joseph D. Romano, R. M. S. Schofield, N. A. Robertson, N. Hindman, D. M. Strom, Robert Spero, Soumya D. Mohanty, C. Aulbert, H. Ward, Scott Koranda, Benjamin J. Owen, E. Maros, C. King, N. Zotov, S. Vass, D. Ugolini, Carsten Fallnich, Kasem Mossavi, V. Chickarmane, Stefan Hild, L. Matone, Soma Mukherjee, D. Rose, K. V. Tokmakov, Keisuke Goda, F. Asiri, A. M. Gretarsson, J. Myers, K. Mason, P. Ehrens, W. Kells, D. Busby, Martin Hewitson, E. Messaritaki, H. Tariq, P. Schwinberg, B. Bhawal, Sheila Rowan, Sanjeev Dhurandhar, J. Castiglione, K. Rawlins, A. Bunkowski, Erik Katsavounidis, D. Webber, S. Ray-Majumder, Suvadeep Bose, V. Re, M. A. Barton, A. Sibley, H. Yamamoto, R. Bork, Stephen Fairhurst, Timothy Evans, R. Coldwell, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, E. Black, M. J. Lubinski, D.B. DeBra, P. Charlton, Carlo Ungarelli, Martin M. Fejer, J. R. Smith, Rainer Weiss, R. W. P. Drever, M. R. Smith, S. W. Ballmer, A. Di Credico, T. Nash, O. Matherny, A. Sazonov, C. N. Colacino, Vladimir B. Braginsky, K. Y. Franzen, W. W. Johnson, B. Barr, K. Riles, G. Moreno, Kenneth A. Strain, I. Leonor, A. Weidner, A. Gillespie, J. Worden, Eric K. Gustafson, Laura Cadonati, W. O. Hamilton, I. A. Bilenko, V. Dergachev, Ian Taylor, Yi Chen, M. Hennessy, Q. Z. Shu, M. Hammond, R. A. Mercer, S. Killbourn, A. Rüdiger, B. O'Reilly, David J. Ottaway, John Veitch, S. Wen, T. T. Lyons, James Whelan, R. Riesen, L. Zhang, R. McCarthy, Yousuke Itoh, Susan M. Scott, E. J. Daw, J. Kern, V. V. Frolov, L. Jones, Robert Bennett, Roland Schilling, G. H. Sanders, R. Lawrence, Teviet Creighton, Herbert Walther, V. Parameshwaraiah, C. Torres, A. J. Weinstein, W. Wu, C. Barker, X. Siemens, K. Kötter, P. G. Murray, C. Wilkinson, J. H. Hough, M. Landry, D. Chin, B. Bochner, Stanislav Babak, Walid A. Majid, J. W C McNabb, Richard J. Abbott, Douglas R. Cook, Duncan A. Brown, F. Nocera, Michele Zanolin, S. Seel, A. Grant, S. Liu, Brent Ware, M. MacInnis, Peter Fritschel, G. Traylor, Thomas Corbitt, Akiteru Takamori, S. E. Whitcomb, S. J. Berukoff, K. Reithmaier, Andreas Freise, A. Libson, Matthew Pitkin, R. Wooley, D. Barker, S. Chelkowski, S. Roddy, A. M. Sintes, P. Aufmuth, Lee Samuel Finn, M. Barnes, Julien Sylvestre, L. Wallace, R. Frey, P. J. King, D. Grimmett, Philip Nutzman, A. G. Wiseman, D. C. Coyne, I. Yakushin, Guenakh Mitselmakher, R. Zhu, L. Sievers, Thomas Cokelaer, Y. Hefetz, Gerhard Heinzel, C. Hardham, Benno Willke, Alessandra Buonanno, A. Wilson, C. A. Cantley, Benjamin William Allen, Karsten Danzmann, M. C. Sumner, Erika D'Ambrosio, Kip S. Thorne, V. P. Mitrofanov, M. C. Araya, D. Steussy, B. Sears, Vicky Kalogera, J. Mason, B. F. Whiting, H. Overmier, M. Coles, M. Guenther, Michael D. Smith, Patrick Brady, Seiji Kawamura, J. A. Giaime, Reinhard Prix, Osamu Miyakawa, David H. Reitze, Christian J. Killow, Roy Williams, K. S. Ganezer, K. Watts, Stefan Goßler, K. T. Reilly, Kevin C. Schlaufman, Herbert Welling, Nergis Mavalvala, B. C. Barish, K. D. Zaleski, R. DeSalvo, Adrian C. Ottewill, K. Mailand, Richard L. Savage, Krzysztof Belczynski, Jeffrey A. Edlund, R. Mittleman, R. Burgess, D. I. Robertson, Nelson Christensen, A. Hartunian, J. Heefner, Michele Vallisneri, Ik Siong Heng, S. Márka, R. J. Dupuis, E. Rotthoff, Gregory M. Harry, M. Lei, Rana X. Adhikari, B. Machenschalk, T. Olson, A. Khan, Virginio Sannibale, David E. McClelland, I. Zawischa, Curt Cutler, A. Ivanov, H. Radkins, S. P. Vyachanin, W. Tyler, Raymond G. Beausoleil, R. Balasubramanian, M. Ashley, Jolien D. E. Creighton, Lindy Blackburn, Chunglee Kim, V. Sandberg, B. J. Cusack, S. R. Rao, and The LIGO Scientific Collaboration
Subjects: stars, Nuclear and High Energy Physics, Gravitational-wave observatory, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, General Relativity and Quantum Cosmology (gr-qc), Astrophysics, 01 natural sciences, General Relativity and Quantum Cosmology, Observatory, 0103 physical sciences, emission, ddc:530, 010303 astronomy & astrophysics, QC, curve, unusual supernova, Physics, optical afterglow, 010308 nuclear & particles physics, Gravitational wave, Astrophysics (astro-ph), Astronomy, dynamics, LIGO, core-collapse, explorer, Supernova, Interferometry, grb-030329, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, Gamma-ray burst, signal
Abstract: We have performed a search for bursts of gravitational waves associated with the very bright Gamma Ray Burst GRB030329, using the two detectors at the LIGO Hanford Observatory. Our search covered the most sensitive frequency range of the LIGO detectors (approximately 80-2048 Hz), and we specifically targeted signals shorter than 150 ms. Our search algorithm looks for excess correlated power between the two interferometers and thus makes minimal assumptions about the gravitational waveform. We observed no candidates with gravitational wave signal strength larger than a pre-determined threshold. We report frequency dependent upper limits on the strength of the gravitational waves associated with GRB030329. Near the most sensitive frequency region, around 250 Hz, our root-sum-square (RSS) gravitational wave strain sensitivity for optimally polarized bursts was better than h_RSS = 6E-21 Hz^{-1/2}. Our result is comparable to the best published results searching for association between gravitational waves and GRBs., Comment: 18 pages, 9 figures and 3 tables; Updated according to journal reviewer's comments
Published: 2005
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14. Upper limits from the LIGO and TAMA detectors on the rate of gravitational-wave bursts

Author: H. Ward, A. Chandler, Kevin M. Ryan, T. Regimbau, Ken'ichi Nakagawa, C. I. Torrie, John Veitch, A. Heptonstall, M. Malec, Jordan Camp, J. Dalrymple, M. Ashley, A. S. Sengupta, Norikatsu Mio, Shinji Miyoki, Jun'ichi Yokoyama, J. Allen, N. Hepler, Akira Okutomi, Phil Willems, D. M. Strom, A. Yamamoto, Jolien D. E. Creighton, Lindy Blackburn, Matthew Evans, L. Cardenas, Yi Pan, Takashi Kuwabara, Richard J. K. Taylor, Gianpietro Cagnoli, Shihori Sakata, C. Aulbert, M. MacInnis, Keita Kawabe, R. S. Amin, Chunglee Kim, Seiji Kawamura, Hiroyuki Nakano, Reinhard Prix, Juri Agresti, A. Rizzi, V. Sandberg, K. Rawlins, A. Bunkowski, Shuzo Takemoto, S. Klimenko, Ryutaro Takahashi, W. R. Johnston, Masa-Katsu Fujimoto, Osamu Miyakawa, David H. Reitze, Christian J. Killow, G. Mendell, J. Myers, Shourov Chatterji, Lindon J. Robison, Helena Armandula, E. J. Elliffe, Suvadeep Bose, A. Ageev, Daisuke Tatsumi, A. Wilson, Kazuyuki Miura, Roy Williams, Kenji Soida, K. S. Ganezer, J. S. Noel, Hiromi Mizusawa, Namio Matsuda, J. Castiglione, Lisa M. Goggin, D. Rose, Hideki Asada, Jan Harms, K. Watts, T. Summerscales, Michael Landry, Roman Schnabel, C. A. Shapiro, Masaru Shibata, Stefan Goßler, K. T. Reilly, Toru Tanji, T. Nakamura, B. F. Whiting, David H. Shoemaker, V. Re, Y. Ogawa, Norihiko Kamikubota, Y. Hefetz, Gerhard Heinzel, C. Hardham, M. R. Smith, Masatake Ohashi, H. Overmier, Robert J. McCarthy, Linqing Wen, Shuichi Sato, Joseph D. Romano, C. King, Shoken M. Miyama, Kasem Mossavi, P. Charlton, A. Di Credico, I. A. Bilenko, V. Dergachev, Ian Taylor, David J. Ottaway, Laura Cadonati, G. Billingsley, D. Sellers, Amber Stuver, Sanichiro Yoshida, A. Ivanov, Y. Saito, J. E. Brau, Subhasish Mitra, D. Churches, P. G. Murray, J. H. Hough, C. Parameswariah, J. Langdale, G. P. Newton, M. Fyffe, Sandra E. Wiley, Gabriela Gonzalez, M. Hrynevych, Peter H. Sneddon, Graham Woan, Zong Hong Zhu, Robert L. Byer, Stuart Reid, Kevin C. Schlaufman, Scott Koranda, Akitoshi Ueda, A. Gillespie, Susan M. Scott, Teviet Creighton, Herbert Welling, F. Mann, Rainer Weiss, Kiminori Kondo, Herbert Walther, Benno Willke, R. W. P. Drever, Nergis Mavalvala, H. Radkins, R. L. Savage, L. Ruet, S. P. Vyachanin, M. Coles, L. Matone, M. Guenther, Yasufumi Kojima, E. Rotthoff, Misao Sasaki, Naoko Ohishi, B. C. Barish, Takaharu Kaneyama, M. Rakhmanov, Michael D. Smith, Bernard F. Schutz, Chad Hanna, G. Stapfer, J. Hanson, C. Torres, A. Rodriguez, S. Meshkov, C. Barker, X. Siemens, K. Kötter, Douglas R. Cook, Michael E Zucker, W. Tyler, Michele Zanolin, S. Seel, C. Wilkinson, G. H. Sanders, R. Lawrence, Mitsuru Musha, W. W. Johnson, B. Johnson, S. Nagano, R. L. Ward, K. D. Zaleski, D. Redding, J. Garofoli, Alessandra Buonanno, R. DeSalvo, Patrick Brady, C. A. Cantley, A. Sibley, Raymond G. Beausoleil, R. Balasubramanian, Ryuichi Fujita, I. Leonor, John K. Cannizzo, C. Robinson, Benjamin William Allen, Alberto Vecchio, M. A. Barton, Rana X. Adhikari, Yoshitaka Nagayama, Guido Mueller, Gareth Jones, B. Machenschalk, R. Rahkola, Pankaj Sarin, Karsten Danzmann, M. C. Sumner, B. Lantz, J. Chapsky, H. Yamamoto, Hideo Iguchi, Tatsuru Yoshida, P. Hoang, Manuel Luna, J. H. Romie, K. Bayer, F. Nocera, F. J. Raab, D.B. DeBra, T. Etzel, K. Y. Franzen, Keisuke Goda, Gavin Davies, Marco G. Tarallo, I. Salzman, D. Farnham, D. Steussy, B. Sears, Akito Araya, V. Schmidt, R. M. S. Schofield, David Jones, Hideaki Kudoh, Benjamin J. Owen, A. M. Gretarsson, Tomiyoshi Haruyama, W. O. Hamilton, R. Gustafson, Erik Katsavounidis, Eugeniy E. Mikhailov, B. J. Cusack, M. Hammond, Kimio Tsubono, Vicky Kalogera, J. Kern, Jeffrey A. Edlund, E. J. Daw, M. J. Lubinski, William E. Butler, D. B. Kozak, E. Myers, K. V. Tokmakov, Takayuki Tomaru, E. Messaritaki, S. Killbourn, Martin Hewitson, Koji Arai, R. Burgess, Daniel C. Woods, B. Rivera, D. Webber, Peter R. Saulson, Hisa-aki Shinkai, L. Jones, M. Lormand, H. Ding, R. Abbott, M. Fine, V. Quetschke, Sheila Rowan, James Whelan, P. Ajith, C. Vorvick, Takashi Uchiyama, Kunihito Ioka, M. Mageswaran, Peter Fritschel, S. Penn, Masao Tokunari, Vladimir B. Braginsky, K. Reithmaier, Andreas Freise, S. R. Rao, Robert Bennett, A. Libson, Marco Aurelio Diaz, D. I. Robertson, Erika D'Ambrosio, Pamela J. Russell, Souichi Telada, Junwei Cao, K. Riles, Martin P McHugh, M. H. P. M. van Putten, S. Tilav, Matthew Pitkin, J. Heefner, Toshitaka Yamazaki, Mayu Katsuki, P. Schwinberg, Yoshihide Kozai, Bangalore Suryanarayana Sathyaprakash, E. Black, Martin M. Fejer, Hideyuki Tagoshi, J. R. Smith, R. Bork, T. Nash, K. C. Cannon, J. Zweizig, R. Wooley, Kazuhiro Hayama, A. Sazonov, J. Mason, Ken-ichi Nakao, W. G. Anderson, K. Oohara, E. Maros, Peter Shawhan, S. Richman, M. Tibbits, B. P. Abbott, Yousuke Itoh, Oliver Jennrich, K. A. Thorne, J. Betzwieser, Kazuaki Kuroda, Koichi Waseda, N. Sato, M. Kawamura, S. Wen, A. Bullington, Michele Vallisneri, I. Zawischa, Robert Spero, Soumya D. Mohanty, Fumiko Kawazoe, D. Ugolini, Carsten Fallnich, Stefan Hild, S. Vass, L. Bogue, A. J. Weinstein, Ik Siong Heng, Shantanu Desai, J. W C McNabb, W. Wu, P. T. Beyersdorf, N. Zotov, W. Kells, Soma Mukherjee, Taketoshi Kasai, K. Mason, Sanjeev Dhurandhar, Kip S. Thorne, Badri Krishnan, Shigemi Otsuka, S. Ray-Majumder, D. Busby, Curt Cutler, T. Findley, C. Gray, Kentaro Somiya, Naoki Seto, D. Ouimette, M. C. Araya, Antony C. Searle, V. V. Frolov, Kevin M. Carter, Frank Seifert, C. N. Colacino, S. B. Anderson, A. Grant, S. Liu, V. Parameshwaraiah, L. Zhang, V. P. Mitrofanov, G. Traylor, Kenji Numata, Masaki Ando, Thomas Corbitt, Akiteru Takamori, Yusaku Hamuro, Joseph M. Kovalik, D. Chin, Stanislav Babak, Walid A. Majid, Yi Chen, M. Hennessy, Q. Z. Shu, David B. Tanner, M. W. Regehr, M. Sung, Duncan A. Brown, S. Wise, S. Grunewald, Brent Ware, Kouichi Sato, M. Pedraza, Maria Alessandra Papa, T. Akutsu, Kenneth G. Libbrecht, Kent Blackburn, N. A. Robertson, Carlo Ungarelli, Walter Winkler, Morag M. Casey, Harald Lück, P. R. Williams, M. Heurs, Toshikazu Suzuki, B. J. Winjum, A. Marin, Yoshio Nishi, A. C. Melissinos, B. Bochner, Massimo Tinto, David Crooks, Philippe Grandclément, P. J. Sutton, Haisheng Rong, Kazuhiro Yamamoto, N. Hindman, Toshifumi Futamase, P. Ehrens, K. Wette, Timothy Evans, R. Coldwell, D. Sigg, S. W. Ballmer, Y. Tsunesada, G. Moreno, J. Logan, R. K. Nayak, Yoshikazu Karasawa, R. J. Dupuis, Youhei Sato, H. Tariq, Shigenori Moriwaki, Vuk Mandic, Ken-ichi Ueda, J. A. Giaime, Katsuaki Kasahara, Eric K. Gustafson, T. T. Lyons, Albert Lazzarini, J. G. Rollins, T. Delker, F. Asiri, S. E. Whitcomb, Adrian C. Ottewill, K. Mailand, Krzysztof Belczynski, R. Mittleman, Kohei Takeno, B. Bland, Nelson Christensen, U. Weiland, Takahiro Tanaka, S. E. Seader, A. Hartunian, Stephen Fairhurst, O. Matherny, B. Barr, J. Worden, A. Rüdiger, Youhei Fujiki, R. Riesen, Roland Schilling, Nobuhiro Tsuda, Gregory M. Harry, M. Lei, I. Yakushin, Hirotaka Takahashi, T. Olson, Keisuke Taniguchi, Guenakh Mitselmakher, A. Khan, Virginio Sannibale, David E. McClelland, O. Spjeld, R. Zhu, Mitsuhiro Fukushima, C. Messenger, W. Hua, L. Sievers, Thomas Cokelaer, Yuriko Yanagi, Aya Sekido, Hideki Ishizuka, D. Barker, S. Chelkowski, S. Roddy, A. M. Sintes, Lee Samuel Finn, M. Barnes, Julien Sylvestre, Yoichi Aso, L. Wallace, R. Frey, S. Márka, Takakazu Shintomi, P. J. King, D. Grimmett, Philip Nutzman, Kenneth A. Strain, A. G. Wiseman, D. C. Coyne, A. Weidner, R. A. Mercer, B. O'Reilly, P. Csatorday, M. V. Plissi, Nobuyuki Kanda, Hartmut Grote, Yukiyoshi Iida, D. Jungwirth, P. E. Lindquist, Peter Aufmuth, V. Chickarmane, B. Bhawal, S. J. Berukoff, Keiko Kokeyama, M. Ito, The LIGO Scientific Collaboration, and TAMA Collaboration
Subjects: Nuclear and High Energy Physics, noise, Frequency band, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, General Relativity and Quantum Cosmology, Coincidence, gravitational wave detectors, Coincident, 0103 physical sciences, black-hole coalescences, ddc:530, 010303 astronomy & astrophysics, QC, Physics, 010308 nuclear & particles physics, Gravitational wave, Bandwidth (signal processing), Detector, LIGO, Amplitude, gravitational waves, light interferometry, network, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
Abstract: We report on the first joint search for gravitational waves by the TAMA and LIGO collaborations. We looked for millisecond-duration unmodelled gravitational-wave bursts in 473 hr of coincident data collected during early 2003. No candidate signals were found. We set an upper limit of 0.12 events per day on the rate of detectable gravitational-wave bursts, at 90% confidence level. From simulations, we estimate that our detector network was sensitive to bursts with root-sum-square strain amplitude above approximately 1-3x10^{-19} Hz^{-1/2} in the frequency band 700-2000 Hz. We describe the details of this collaborative search, with particular emphasis on its advantages and disadvantages compared to searches by LIGO and TAMA separately using the same data. Benefits include a lower background and longer observation time, at some cost in sensitivity and bandwidth. We also demonstrate techniques for performing coincidence searches with a heterogeneous network of detectors with different noise spectra and orientations. These techniques include using coordinated signal injections to estimate the network sensitivity, and tuning the analysis to maximize the sensitivity and the livetime, subject to constraints on the background., Comment: 15 pages, 11 figures, to be submitted to Phys Rev D. Updated author list
Published: 2005

15. First all-sky upper limits from LIGO on the strength of periodic gravitational waves using the Hough transform

Author: A. L. Stuver, B. Lantz, H. Yamamoto, David Crooks, Peter Aufmuth, V. Chickarmane, B. F. Whiting, B. Bhawal, J. S. Noel, S. J. Berukoff, K. D. Zaleski, K. Reithmaier, Andreas Freise, A. Libson, I. Salzman, S. Márka, D. B. Kozak, R. L. Ward, R. DeSalvo, Kenneth A. Strain, A. Weidner, R. A. Mercer, B. O'Reilly, H. Overmier, R. M. S. Schofield, Matthew Pitkin, R. Wooley, P. Csatorday, Alberto Vecchio, Y. Hefetz, Gerhard Heinzel, C. Hardham, Badri Krishnan, I. Leonor, John K. Cannizzo, M. V. Plissi, W. R. Johnston, C. Vorvick, J. Castiglione, Benjamin J. Owen, A. Wilson, Gregory M. Harry, J. H. Romie, Hartmut Grote, Antony C. Searle, M. Lei, D. Sellers, D. Jungwirth, Benno Willke, W. O. Hamilton, P. E. Lindquist, J. Logan, R. K. Nayak, E. Myers, K. Bayer, A. Ageev, K. V. Tokmakov, P. Charlton, A. Di Credico, F. J. Raab, T. Olson, E. Rotthoff, C. A. Shapiro, N. Hindman, R. Rahkola, L. Ruet, M. Coles, M. Guenther, G. Mendell, S. Killbourn, James Whelan, H. Ding, Martin Hewitson, I. A. Bilenko, V. Dergachev, Ian Taylor, Jan Harms, Frank Seifert, A. Khan, Joseph M. Kovalik, Richard L. Savage, Keisuke Goda, W. G. Anderson, Rana X. Adhikari, Virginio Sannibale, David E. McClelland, Alessandra Buonanno, Patrick Brady, Peter Shawhan, Gareth Jones, I. Yakushin, Sanichiro Yoshida, C. Parameswariah, David J. Ottaway, R. Gustafson, Erik Katsavounidis, R. J. Dupuis, B. Machenschalk, M. Tibbits, B. P. Abbott, C. A. Cantley, Adrian C. Ottewill, Lindon J. Robison, H. Tariq, Graham Woan, S. Vass, C. Robinson, M. J. Lubinski, J. Langdale, G. P. Newton, M. Fyffe, Sandra E. Wiley, B. J. Cusack, Robert L. Byer, Stuart Reid, Scott Koranda, Benjamin William Allen, K. Mailand, L. Matone, Morag M. Casey, M. Heurs, Gavin Davies, D. Steussy, B. Sears, D. Rose, B. J. Winjum, Michael E Zucker, M. Rakhmanov, Richard J. K. Taylor, Helena Armandula, E. J. Elliffe, Bernard F. Schutz, Krzysztof Belczynski, R. Mittleman, Nelson Christensen, A. Hartunian, W. Kells, D. Busby, Vicky Kalogera, Gianpietro Cagnoli, Vuk Mandic, S. Meshkov, Karsten Danzmann, M. C. Sumner, Vladimir B. Braginsky, K. Riles, G. Stapfer, H. Ward, A. Sibley, Guenakh Mitselmakher, O. Spjeld, R. Zhu, E. J. Daw, S. R. Rao, J. A. Giaime, Eric K. Gustafson, A. C. Melissinos, J. Hanson, Jeffrey A. Edlund, R. Burgess, Erika D'Ambrosio, Gabriela Gonzalez, Guido Mueller, Manuel Luna, S. Nagano, M. Ashley, V. Re, T. Etzel, T. T. Lyons, D. Redding, O. Matherny, Daniel C. Woods, J. Myers, J. Zweizig, I. Zawischa, J. Allen, N. Hepler, Yousuke Itoh, J. W C McNabb, Robert J. McCarthy, Linqing Wen, Albert Lazzarini, Shourov Chatterji, P. Hoang, Roman Schnabel, Soma Mukherjee, Suvadeep Bose, J. E. Brau, D. I. Robertson, Roy Williams, Rainer Weiss, Philippe Grandclément, P. Ehrens, P. J. Sutton, B. Barr, L. Sievers, P. Schwinberg, R. W. P. Drever, Jolien D. E. Creighton, Shantanu Desai, Haisheng Rong, C. Messenger, Subhasish Mitra, Kip S. Thorne, D. Churches, D. Webber, W. W. Johnson, Robert Spero, Soumya D. Mohanty, J. Mason, Thomas Cokelaer, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, John Veitch, Lindy Blackburn, Chunglee Kim, V. Sandberg, J. Worden, Kevin M. Carter, M. R. Smith, Eugeniy E. Mikhailov, P. G. Murray, T. Regimbau, David Jones, E. Black, M. Barnes, Julien Sylvestre, Martin M. Fejer, J. R. Smith, R. Bork, K. S. Ganezer, W. Hua, T. Findley, S. B. Anderson, Joseph D. Romano, C. King, Kasem Mossavi, D. Ouimette, K. Watts, C. I. Torrie, A. Heptonstall, V. P. Mitrofanov, K. Wette, Juri Agresti, Timothy Evans, A. Rizzi, L. Wallace, R. Coldwell, R. Frey, M. Malec, J. G. Rollins, J. H. Hough, Douglas R. Cook, A. Rüdiger, T. Nash, N. Zotov, K. Mason, Sanjeev Dhurandhar, P. J. King, S. Ray-Majumder, A. Sazonov, M. MacInnis, D. Grimmett, Marco Aurelio Diaz, A. Parameswaran, Philip Nutzman, A. Ivanov, H. Radkins, David B. Tanner, M. Lormand, M. W. Regehr, M. Fine, G. H. Sanders, R. Lawrence, A. M. Gretarsson, Michele Zanolin, D. Sigg, S. W. Ballmer, Peter R. Saulson, T. Delker, A. G. Wiseman, T. Summerscales, G. Moreno, R. S. Amin, Seiji Kawamura, Reinhard Prix, Stefan Goßler, K. T. Reilly, R. Riesen, S. P. Vyachanin, W. Tyler, M. Sung, A. Gillespie, A. Chandler, S. Wise, S. Seel, S. Grunewald, R. Abbott, D. C. Coyne, Michael Landry, Peter H. Sneddon, Roland Schilling, Phil Willems, Raymond G. Beausoleil, R. Balasubramanian, Curt Cutler, E. Messaritaki, Kevin M. Ryan, Osamu Miyakawa, M. Pedraza, A. Bullington, Kevin C. Schlaufman, G. Billingsley, C. N. Colacino, V. V. Frolov, Sheila Rowan, M. C. Araya, D. Barker, Maria Alessandra Papa, Herbert Welling, Kenneth G. Libbrecht, L. Bogue, V. Parameshwaraiah, S. Penn, J. Garofoli, David H. Reitze, Christian J. Killow, Nergis Mavalvala, S. Chelkowski, Pamela J. Russell, S. Richman, A. J. Weinstein, S. Roddy, Oliver Jennrich, Kent Blackburn, W. Wu, B. C. Barish, D. Chin, Stanislav Babak, Walid A. Majid, M. Ito, Yi Chen, K. A. Thorne, J. Betzwieser, J. Heefner, N. A. Robertson, A. M. Sintes, D. Ugolini, M. Hennessy, Q. Z. Shu, Carsten Fallnich, Duncan A. Brown, Lee Samuel Finn, Jordan Camp, Stefan Hild, J. Dalrymple, A. S. Sengupta, D. M. Strom, Brent Ware, A. Grant, S. Liu, K. Kawabe, B. Rivera, L. Zhang, M. Mageswaran, Carlo Ungarelli, Michele Vallisneri, Ik Siong Heng, Walter Winkler, Harald Lück, P. R. Williams, Matthew Evans, L. Cardenas, Yi Pan, S. Klimenko, A. Marin, B. Bochner, Massimo Tinto, B. Bland, U. Weiland, S. E. Seader, Lisa M. Goggin, K. Rawlins, A. Bunkowski, Stephen Fairhurst, M. A. Barton, F. Asiri, S. E. Whitcomb, D.B. DeBra, David H. Shoemaker, K. Y. Franzen, Peter Fritschel, C. Torres, K. C. Cannon, M. Hammond, A. Rodriguez, M. W.E. Smith, J. Kern, L. Jones, C. Barker, Pankaj Sarin, Shinji Miyoki, D. Farnham, C. Aulbert, F. Mann, V. Schmidt, G. Traylor, R. Bennett, William E. Butler, Thomas Corbitt, Akiteru Takamori, Martin P McHugh, M. H. P. M. van Putten, S. Tilav, E. Maros, Laura Cadonati, M. Hrynevych, Susan M. Scott, Teviet Creighton, Herbert Walther, X. Siemens, K. Kötter, C. Wilkinson, F. Nocera, B. Johnson, J. Chapsky, S. Wen, and C. Gray
Subjects: Nuclear and High Energy Physics, Gravitational-wave observatory, interferometer, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, Radio spectrum, General Relativity and Quantum Cosmology, Hough transform, law.invention, precessing neutron-stars, Pulsar, law, 0103 physical sciences, emission, ddc:530, 010306 general physics, QC, Physics, search, detector, 010308 nuclear & particles physics, Gravitational wave, LIGO, geo-600, Neutron star, Amplitude, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
Abstract: We perform a wide parameter space search for continuous gravitational waves over the whole sky and over a large range of values of the frequency and the first spin-down parameter. Our search method is based on the Hough transform, which is a semi-coherent, computationally efficient, and robust pattern recognition technique. We apply this technique to data from the second science run of the LIGO detectors and our final results are all-sky upper limits on the strength of gravitational waves emitted by unknown isolated spinning neutron stars on a set of narrow frequency bands in the range 200-$400 $Hz. The best upper limit on the gravitational wave strain amplitude that we obtain in this frequency range is $4.43\times 10^{-23}$., Comment: 22 pages, 21 figures, to be submitted to Phys. Rev. D
Published: 2005
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16. Limits on gravitational-wave emission from selected pulsars using LIGO data

Author: Peter Aufmuth, Y. Hefetz, Gerhard Heinzel, C. Hardham, V. Chickarmane, C. Gray, Benno Willke, H. Tariq, P. Williams, Alessandra Buonanno, Erika D'Ambrosio, T. Summerscales, D. B. Kozak, K. D. Zaleski, Laura Cadonati, Susan M. Scott, Teviet Creighton, Herbert Walther, C. Torres, X. Siemens, K. Kötter, C. Messenger, B. Bhawal, Peter Fritschel, M. Lormand, M. Fine, G. Traylor, Thomas Corbitt, Akiteru Takamori, C. Vorvick, F. Nocera, Alicia M. Sintes, R. DeSalvo, P. G. Murray, T. Regimbau, C. I. Torrie, A. Heptonstall, G. Billingsley, Phil Willems, A. Bullington, L. Bogue, V. V. Frolov, Kip S. Thorne, R. L. Savage, D. M. Strom, J. A. Giaime, Eric K. Gustafson, J. H. Hough, M. Barnes, Julien Sylvestre, W. Hua, Shuhei Yoshida, D. Farnham, J. Romie, Douglas R. Cook, Walter Winkler, Michael Kramer, L. Matone, V. Parameshwaraiah, F. Asiri, A. M. Gretarsson, B. Lantz, W. G. Anderson, E. Messaritaki, I. Salzman, V. P. Mitrofanov, Michele Zanolin, S. Seel, Keisuke Goda, M. A. Barton, Shigeo Nagano, S. Roddy, N. A. Robertson, F. J. Raab, Harald Lück, W. R. Johnston, Peter Shawhan, Robert Spero, Soumya D. Mohanty, Jeffrey A. Edlund, D. Chin, Stanislav Babak, J. Garofoli, B. F. Whiting, M. Tibbits, B. P. Abbott, Benjamin J. Owen, Sheila Rowan, C. Wilkinson, H. Ward, Erik Katsavounidis, V. Re, Badri Krishnan, V. Sannibale, L. Wallace, R. Burgess, R. Frey, K. V. Tokmakov, William E. Butler, D.B. DeBra, N. Zotov, Albrecht Rüdiger, Antony C. Searle, M. J. Lubinski, A. Wilson, T. T. Lyons, R. Taylor, B. J. Cusack, Duncan A. Brown, Rainer Weiss, K. Y. Franzen, S. Vass, H. Overmier, Martin Hewitson, R. W. P. Drever, Vladimir B. Braginsky, John Worden, A. Ageev, Frank Seifert, Adrian C. Ottewill, D. I. Robertson, Graham Woan, W. W. Johnson, Joseph M. Kovalik, K. Riles, K. Mailand, J. Logan, R. K. Nayak, K. Mason, Robert L. Byer, Stuart Reid, Jan Harms, Martin P McHugh, Brent Ware, Krzysztof Belczynski, M. H. P. M. van Putten, D. Grimmett, Philip Nutzman, M. Hammond, J. Heefner, Sanjeev Dhurandhar, S. Ray-Majumder, W. Kells, D. Busby, C. A. Shapiro, S. Berukoff, Lindon J. Robison, Corey Cutler, H. Yamamoto, R. Mittleman, Nelson Christensen, A. Hartunian, Michael E Zucker, Jordan Camp, R. Rahkola, Yousuke Itoh, Helena Armandula, S. E. Whitcomb, E. J. Elliffe, S. Gossler, T. Findley, S. R. Rao, G. Mendell, J. Kern, M. Rakhmanov, L. Jones, M. Coles, Simon Chelkowski, S. Tilav, Bernard F. Schutz, C. A. Cantley, C. N. Colacino, A. G. Wiseman, G. Stapfer, A. S. Sengupta, G. Newton, J. Hanson, Benjamin William Allen, Robert Bennett, A. J. Weinstein, Karsten Danzmann, M. C. Sumner, W. Wu, John Veitch, Carlo Ungarelli, M. Ashley, M. Landry, Michael D. Smith, Robert J. McCarthy, Linqing Wen, C. Parameswariah, S. Meshkov, M. C. Araya, D. C. Coyne, W. O. Hamilton, Guido Mueller, D. Rose, E. Maros, M. MacInnis, Michele Vallisneri, Ik Siong Heng, Patrick Brady, K. Reithmaier, P. Russell, Andreas Freise, Matthew Evans, L. Cardenas, M. Malec, Scott Koranda, S. Killbourn, S. Márka, James Whelan, Yi Pan, Joseph D. Romano, C. King, Yi Chen, M. Hennessy, Q. Z. Shu, J. Langdale, M. Fyffe, S. Wise, Sandra E. Wiley, Gabriela Gonzalez, A. Grant, S. Liu, P. Schwinberg, A. Libson, Matthew Pitkin, I. Leonor, S. Grunewald, D. Steussy, B. Sears, R. J. Dupuis, Kasem Mossavi, R. Wooley, L. Zhang, Andrew Lyne, S. Klimenko, Marco Aurelio Diaz, Jolien D. E. Creighton, Vicky Kalogera, Shinji Miyoki, V. Schmidt, B. Bochner, K. Bayer, W. Majid, D. Barker, Lindy Blackburn, K. Rawlins, Chunglee Kim, M. Guenther, Gregory M. Harry, E. J. Daw, M. Lei, Roman Schnabel, V. Sandberg, J. E. Brau, Kenneth A. Strain, A. Weidner, Kenneth G. Libbrecht, Albert Lazzarini, R. A. Mercer, Roy Williams, D. Churches, T. Etzel, K. S. Ganezer, A. Chandler, Massimo Tinto, C. Aulbert, I. Zawischa, A. Sibley, S. Wen, Rana X. Adhikari, A. Khan, R. Gustafson, B. Machenschalk, K. Watts, K. T. Reilly, S. Penn, D. Redding, B. O'Reilly, A. Sazonov, David E. McClelland, J. W C McNabb, N. Hepler, R. Zhu, S. Chatterji, A. Ivanov, A. Rizzi, B. Bland, Seiji Kawamura, T. Olson, Reinhard Prix, H. Radkins, U. Weiland, Soma Mukherjee, D. Jungwirth, P. Hoang, S. Richman, Oliver Jennrich, Kevin M. Carter, J. Zweizig, P. Csatorday, S. B. Anderson, Osamu Miyakawa, David H. Reitze, Lee Samuel Finn, A. Marin, David H. Shoemaker, R. Amin, D. Webber, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, E. Black, David B. Tanner, M. W. Regehr, S. P. Vyachanin, W. Tyler, Raymond G. Beausoleil, Kevin C. Schlaufman, Peter H. Sneddon, Herbert Welling, Nergis Mavalvala, Martin M. Fejer, R. Balasubramanian, J. R. Smith, J. Mason, S. E. Seader, R. Bork, Christian J. Killow, T. Nash, K. A. Thorne, J. Betzwieser, D. Ugolini, B. C. Barish, M. V. Plissi, M. Pedraza, T. Delker, Kris Ryan, J. Rollins, Maria Alessandra Papa, I. Yakushin, F. Mann, Kent Blackburn, Alberto Vecchio, Hartmut Grote, Guenakh Mitselmakher, Carsten Fallnich, Stefan Hild, A. Bunkowski, K. Kawabe, B. Rivera, David Jones, M. Hrynevych, B. Johnson, M. Mageswaran, P. E. Lindquist, C. Barker, R. Schofield, M. Ito, L. Sievers, Thomas Cokelaer, Peter R. Saulson, H. Ding, J. Chapsky, R. Abbott, Stephen Fairhurst, A. L. Stuver, O. Matherny, Phil D. C. King, J. S. Noel, J. Castiglione, P. Charlton, M. R. Smith, D. Ouimette, A. Di Credico, B. Barr, I. A. Bilenko, V. Dergachev, Ian Taylor, David J. Ottaway, Philippe Grandclément, P. J. Sutton, Haisheng Rong, R. Riesen, Roland Schilling, G. H. Sanders, R. Lawrence, Gianpietro Cagnoli, J. Myers, Suvadeep Bose, Morag M. Casey, M. Heurs, B. J. Winjum, David Crooks, N. Hindman, E. Rotthoff, P. Ehrens, Timothy Evans, R. Coldwell, D. Sigg, S. W. Ballmer, G. Moreno, A. Gillespie, and The LIGO Scientific Collaboration
Subjects: Astrophysics::High Energy Astrophysical Phenomena, Phase (waves), General Physics and Astronomy, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), Gravity waves, Interferometric detectors, Strain limit, 01 natural sciences, General Relativity and Quantum Cosmology, Gravitation, Pulsar, 0103 physical sciences, ddc:530, 010303 astronomy & astrophysics, QC, Pulsars, Physics, 010308 nuclear & particles physics, Gravitational wave, Radio observation, Detector, Astrophysics (astro-ph), Astrophysics::Instrumentation and Methods for Astrophysics, Gravitational effects, Astronomy, Gravitational-wave signals, LIGO, Upper limits, Interferometry, Amplitude, Gravitational-wave emission, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, Radio pulsars, Coherent multidetector analysis
Abstract: We place direct upper limits on the amplitude of gravitational waves from 28 isolated radio pulsars by a coherent multi-detector analysis of the data collected during the second science run of the LIGO interferometric detectors. These are the first direct upper limits for 26 of the 28 pulsars. We use coordinated radio observations for the first time to build radio-guided phase templates for the expected gravitational wave signals. The unprecedented sensitivity of the detectors allow us to set strain upper limits as low as a few times $10^{-24}$. These strain limits translate into limits on the equatorial ellipticities of the pulsars, which are smaller than $10^{-5}$ for the four closest pulsars., Comment: 6 pages, 2 figures
Published: 2005
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17. Setting upper limits on the strength of periodic gravitational waves from PSRJ1939+2134using the first science data from the GEO 600 and LIGO detectors

Author: A. S. Sengupta, Michael E Zucker, T. Regimbau, M. R. Pratt, Matthew Evans, C. I. Torrie, K. Reithmaier, Andreas Freise, L. Cardenas, A. Heptonstall, M. Malec, S. Klimenko, Phil Willems, A. Wilson, Albert Lazzarini, D. M. Strom, Marco Aurelio Diaz, D. Rose, Matthew Pitkin, R. Wooley, Rainer Weiss, R. W. P. Drever, W. W. Johnson, M. Lormand, M. Fine, Richard Ingley, I. Zawischa, O. Matherny, A. Bullington, M. Schrempel, L. Bogue, S. Gossler, A. Ageev, Shinji Miyoki, Badri Krishnan, Antony C. Searle, B. Barr, J. Worden, C. A. Cantley, Benjamin William Allen, Karsten Danzmann, M. C. Sumner, Y. Hefetz, Gerhard Heinzel, C. Hardham, Laura Cadonati, Chunglee Kim, W. R. Johnston, J. G. Rollins, C. Aulbert, H. Ward, B. F. Whiting, Joseph M. Kovalik, Peter Aufmuth, D. Farnham, Benno Willke, I. Leonor, Susan M. Scott, Teviet Creighton, R. Riesen, Herbert Walther, Roland Schilling, R. Taylor, V. Chickarmane, T. Delker, Alessandra Buonanno, B. Lantz, S. Meshkov, K. Kötter, V. Schmidt, Erika D'Ambrosio, R. Davies, R. Bennett, William E. Butler, P. Ehrens, S. Traeger, M. Ito, V. Leonhardt, Albrecht Rüdiger, F. Nocera, Martin Hewitson, Alicia M. Sintes, J. Logan, R. K. Nayak, Walter Winkler, C. A. Shapiro, M. MacInnis, D. Redding, A. Ivanov, B. Bland-Weaver, Lindon J. Robison, H. Radkins, Harald Lück, P. Williams, B. Bhawal, Martin P McHugh, B. Mours, M. H. P. M. van Putten, Curt Cutler, S. Tilav, D. Jungwirth, P. Hoang, Peter H. Sneddon, J. D. E. Creighton, Kip S. Thorne, M. Hrynevych, Helena Armandula, E. J. Elliffe, Roy Williams, R. Rahkola, S. P. Vyachanin, W. Tyler, Peter Fritschel, Scott Koranda, E. J. Daw, K. S. Ganezer, T. Etzel, U. Weiland, J. Mason, J. E. Brau, M. R. Smith, L. Matone, Raymond G. Beausoleil, R. Balasubramanian, I. Salzman, D. Churches, K. Watts, M. C. Araya, E. Maros, V. P. Mitrofanov, R. M. S. Schofield, Robert J. McCarthy, A. Sibley, Linqing Wen, G. Traylor, B. Sears, Thomas Corbitt, Timothy Evans, R. Coldwell, D. Sigg, S. W. Ballmer, F. Asiri, P. Schwinberg, E. Rotthoff, M. A. Barton, K. Kawabe, A. M. Gretarsson, Rana X. Adhikari, K. T. Reilly, P. Csatorday, M. V. Plissi, D.B. DeBra, D. Webber, Benjamin J. Owen, Akiteru Takamori, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, E. Black, M. Mageswaran, Kevin C. Schlaufman, Sheila Rowan, Martin M. Fejer, Éanna É. Flanagan, B. Machenschalk, Herbert Welling, S. Wise, Joseph D. Romano, M. Hammond, Nergis Mavalvala, J. R. Smith, S. Grunewald, R. Bork, N. A. Robertson, C. King, K. V. Tokmakov, G. Moreno, Kasem Mossavi, A. Gillespie, H. Tariq, T. Nash, A. Sazonov, M. W.E. Smith, J. Kern, Hartmut Grote, V. Parameswariah, S. E. Whitcomb, B. C. Barish, L. Jones, G. Mendell, Soma Mukherjee, D. H. Shoemaker, Kenneth G. Libbrecht, R. DeSalvo, David Crooks, D. B. Kozak, C. Vorvick, Sanichiro Yoshida, C. Parameswariah, P. E. Lindquist, C. Torres, J. Langdale, G. P. Newton, P. Kloevekorn, A. Chandler, A. J. Weinstein, J. A. Giaime, Eric K. Gustafson, M. Fyffe, Kevin M. Ryan, Gabriela Gonzalez, D. Barker, B. J. Cusack, Graham Woan, G. H. Sanders, R. Lawrence, Robert L. Byer, T. T. Lyons, S. Roddy, W. G. Anderson, B. Bochner, Peter Shawhan, Kenneth A. Strain, A. Weidner, Richard L. Savage, M. Landry, M. Tibbits, B. P. Abbott, Massimo Tinto, J. H. Hough, V. V. Frolov, M. Rakhmanov, Bernard F. Schutz, B. O'Reilly, Lee Samuel Finn, S. Vass, S. R. Rao, Shigeo Nagano, D. Chin, Stanislav Babak, Walid A. Majid, C. N. Colacino, G. Stapfer, W. Kells, M. Barnes, Julien Sylvestre, Duncan A. Brown, Jeffrey A. Edlund, H. Overmier, D. Busby, Douglas R. Cook, J. Hanson, P. McNamara, S. Seel, Guido Mueller, L. Wallace, S. Penn, Alberto Vecchio, Brent Ware, S. Berukoff, C. Messenger, A. Grant, S. Liu, R. Frey, L. Zhang, T. Olson, W. Hua, Keisuke Goda, V. Kalogera, R. Burgess, Kevin M. Carter, Pamela J. Russell, S. Richman, Erik Katsavounidis, S. B. Anderson, Oliver Jennrich, P. J. King, D. Grimmett, Philip Nutzman, M. J. Lubinski, A. Rizzi, David B. Tanner, D. I. Robertson, Vladimir B. Braginsky, K. Riles, M. Coles, M. Guenther, A. G. Wiseman, M. W. Regehr, A. Marin, J. Betzwieser, T. Summerscales, Adrian C. Ottewill, Yousuke Itoh, J. Heefner, M. Pedraza, K. Mailand, G. Billingsley, D. Ugolini, Carsten Fallnich, Krzysztof Belczynski, D. C. Coyne, H. Yamamoto, R. Mittleman, Nelson Christensen, A. Hartunian, Maria Alessandra Papa, Patrick Brady, I. Yakushin, N. Hindman, Seiji Kawamura, Guenakh Mitselmakher, Kent Blackburn, Michele Vallisneri, W. O. Hamilton, Ik Siong Heng, Kenneth D. Skeldon, S. Killbourn, D. Ouimette, S. Márka, R. J. Dupuis, Osamu Miyakawa, David H. Reitze, Christian J. Killow, L. Sievers, Gregory M. Harry, M. Lei, Philippe Grandclément, P. J. Sutton, Haisheng Rong, Gianpietro Cagnoli, A. Khan, Virginio Sannibale, David E. McClelland, Morag M. Casey, M. Heurs, B. J. Winjum, J. Myers, C. Ebeling, Suvadeep Bose, Robert Spero, Soumya D. Mohanty, N. Zotov, K. Mason, Sanjeev Dhurandhar, James Whelan, H. Ding, Xavier Siemens, C. Gray, Yi Chen, M. Hennessy, Q. Z. Shu, J. H. Romie, K. Bayer, F. J. Raab, R. Gustafson, R. Amin, C. Barker-Patton, S. Chatterji, F. Mann, J. Zweizig, J. Chapsky, S. Brozek, H. Naundorf, S. Wen, A. L. Stuver, J. Castiglione, P. Charlton, I. A. Bilenko, Ian Taylor, David J. Ottaway, N. Hepler, Peter R. Saulson, R. Abbott, and Jordan Camp
Subjects: Physics, Nuclear and High Energy Physics, Gravitational-wave observatory, 010308 nuclear & particles physics, Gravitational wave, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astrophysics, 01 natural sciences, Gravitational-wave astronomy, Binary pulsar, LIGO, General Relativity and Quantum Cosmology, Neutron star, Pulsar, Frequency domain, 0103 physical sciences, 010303 astronomy & astrophysics
Abstract: Data collected by the GEO 600 and LIGO interferometric gravitational wave detectors during their first observational science run were searched for continuous gravitational waves from the pulsar J1939+2134 at twice its rotation frequency. Two independent analysis methods were used and are demonstrated in this paper: a frequency domain method and a time domain method. Both achieve consistent null results, placing new upper limits on the strength of the pulsar’s gravitational wave emission. A model emission mechanism is used to interpret the limits as a constraint on the pulsar’s equatorial ellipticity.
Published: 2004
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18. Analysis of LIGO data for gravitational waves from binary neutron stars

Author: B. Abbott, R. Abbott, R. Adhikari, A. Ageev, B. Allen, R. Amin, S. B. Anderson, W. G. Anderson, M. Araya, H. Armandula, F. Asiri, P. Aufmuth, C. Aulbert, S. Babak, R. Balasubramanian, S. Ballmer, B. C. Barish, D. Barker, C. Barker-Patton, M. Barnes, B. Barr, M. A. Barton, K. Bayer, R. Beausoleil, K. Belczynski, R. Bennett, S. J. Berukoff, J. Betzwieser, B. Bhawal, I. A. Bilenko, G. Billingsley, E. Black, K. Blackburn, B. Bland-Weaver, B. Bochner, L. Bogue, R. Bork, S. Bose, P. R. Brady, V. B. Braginsky, J. E. Brau, D. A. Brown, S. Brozek, A. Bullington, A. Buonanno, R. Burgess, D. Busby, W. E. Butler, R. L. Byer, L. Cadonati, G. Cagnoli, J. B. Camp, C. A. Cantley, L. Cardenas, K. Carter, M. M. Casey, J. Castiglione, A. Chandler, J. Chapsky, P. Charlton, S. Chatterji, Y. Chen, V. Chickarmane, D. Chin, N. Christensen, D. Churches, C. Colacino, R. Coldwell, M. Coles, D. Cook, T. Corbitt, D. Coyne, J. D. E. Creighton, T. D. Creighton, D. R. M. Crooks, P. Csatorday, B. J. Cusack, C. Cutler, E. D’Ambrosio, K. Danzmann, R. Davies, E. Daw, D. DeBra, T. Delker, R. DeSalvo, S. Dhurandhar, M. Díaz, H. Ding, R. W. P. Drever, R. J. Dupuis, C. Ebeling, J. Edlund, P. Ehrens, E. J. Elliffe, T. Etzel, M. Evans, T. Evans, C. Fallnich, D. Farnham, M. M. Fejer, M. Fine, L. S. Finn, É. Flanagan, A. Freise, R. Frey, P. Fritschel, V. Frolov, M. Fyffe, K. S. Ganezer, J. A. Giaime, A. Gillespie, K. Goda, G. González, S. Goßler, P. Grandclément, A. Grant, C. Gray, A. M. Gretarsson, D. Grimmett, H. Grote, S. Grunewald, M. Guenther, E. Gustafson, R. Gustafson, W. O. Hamilton, M. Hammond, J. Hanson, C. Hardham, G. Harry, A. Hartunian, J. Heefner, Y. Hefetz, G. Heinzel, I. S. Heng, M. Hennessy, N. Hepler, A. Heptonstall, M. Heurs, M. Hewitson, N. Hindman, P. Hoang, J. Hough, M. Hrynevych, W. Hua, R. Ingley, M. Ito, Y. Itoh, A. Ivanov, O. Jennrich, W. W. Johnson, W. Johnston, L. Jones, D. Jungwirth, V. Kalogera, E. Katsavounidis, K. Kawabe, S. Kawamura, W. Kells, J. Kern, A. Khan, S. Killbourn, C. J. Killow, C. Kim, C. King, P. King, S. Klimenko, P. Kloevekorn, S. Koranda, K. Kötter, J. Kovalik, D. Kozak, B. Krishnan, M. Landry, J. Langdale, B. Lantz, R. Lawrence, A. Lazzarini, M. Lei, V. Leonhardt, I. Leonor, K. Libbrecht, P. Lindquist, S. Liu, J. Logan, M. Lormand, M. Lubinski, H. Lück, T. T. Lyons, B. Machenschalk, M. MacInnis, M. Mageswaran, K. Mailand, W. Majid, M. Malec, F. Mann, A. Marin, S. Márka, E. Maros, J. Mason, K. Mason, O. Matherny, L. Matone, N. Mavalvala, R. McCarthy, D. E. McClelland, M. McHugh, P. McNamara, G. Mendell, S. Meshkov, C. Messenger, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, O. Miyakawa, S. Miyoki, S. Mohanty, G. Moreno, K. Mossavi, B. Mours, G. Mueller, S. Mukherjee, J. Myers, S. Nagano, T. Nash, H. Naundorf, R. Nayak, G. Newton, F. Nocera, P. Nutzman, T. Olson, B. O’Reilly, D. J. Ottaway, A. Ottewill, D. Ouimette, H. Overmier, B. J. Owen, M. A. Papa, C. Parameswariah, V. Parameswariah, M. Pedraza, S. Penn, M. Pitkin, M. Plissi, M. Pratt, V. Quetschke, F. Raab, H. Radkins, R. Rahkola, M. Rakhmanov, S. R. Rao, D. Redding, M. W. Regehr, T. Regimbau, K. T. Reilly, K. Reithmaier, D. H. Reitze, S. Richman, R. Riesen, K. Riles, A. Rizzi, D. I. Robertson, N. A. Robertson, L. Robison, S. Roddy, J. Rollins, J. D. Romano, J. Romie, H. Rong, D. Rose, E. Rotthoff, S. Rowan, A. Rüdiger, P. Russell, K. Ryan, I. Salzman, G. H. Sanders, V. Sannibale, B. Sathyaprakash, P. R. Saulson, R. Savage, A. Sazonov, R. Schilling, K. Schlaufman, V. Schmidt, R. Schofield, M. Schrempel, B. F. Schutz, P. Schwinberg, S. M. Scott, A. C. Searle, B. Sears, S. Seel, A. S. Sengupta, C. A. Shapiro, P. Shawhan, D. H. Shoemaker, Q. Z. Shu, A. Sibley, X. Siemens, L. Sievers, D. Sigg, A. M. Sintes, K. Skeldon, J. R. Smith, M. Smith, M. R. Smith, P. Sneddon, R. Spero, G. Stapfer, K. A. Strain, D. Strom, A. Stuver, T. Summerscales, M. C. Sumner, P. J. Sutton, J. Sylvestre, A. Takamori, D. B. Tanner, H. Tariq, I. Taylor, R. Taylor, K. S. Thorne, M. Tibbits, S. Tilav, M. Tinto, K. V. Tokmakov, C. Torres, C. Torrie, S. Traeger, G. Traylor, W. Tyler, D. Ugolini, M. Vallisneri, M. van Putten, S. Vass, A. Vecchio, C. Vorvick, S. P. Vyachanin, L. Wallace, H. Walther, H. Ward, B. Ware, K. Watts, D. Webber, A. Weidner, U. Weiland, A. Weinstein, R. Weiss, H. Welling, L. Wen, S. Wen, J. T. Whelan, S. E. Whitcomb, B. F. Whiting, P. A. Willems, P. R. Williams, R. Williams, B. Willke, A. Wilson, B. J. Winjum, W. Winkler, S. Wise, A. G. Wiseman, G. Woan, R. Wooley, J. Worden, I. Yakushin, H. Yamamoto, S. Yoshida, I. Zawischa, L. Zhang, N. Zotov, M. Zucker, J. Zweizig, and The LIGO Scientific Collaboration
Subjects: Nuclear and High Energy Physics, Gravitational-wave observatory, relativistic gravity, Milky Way, interferometer, Binary number, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, coalescence rates, General Relativity and Quantum Cosmology, 0103 physical sciences, ddc:530, 010306 general physics, QC, Astrophysics::Galaxy Astrophysics, detectors, pulsar, Physics, inspiraling compact binaries, 010308 nuclear & particles physics, Gravitational wave, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Galaxy, LIGO, laser, Neutron star, Interferometry, search templates, systems, forms, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
Abstract: We report on a search for gravitational waves from coalescing compact binary systems in the Milky Way and the Magellanic Clouds. The analysis uses data taken by two of the three LIGO interferometers during the first LIGO science run and illustrates a method of setting upper limits on inspiral event rates using interferometer data. The analysis pipeline is described with particular attention to data selection and coincidence between the two interferometers. We establish an observational upper limit of $\mathcal{R}, Comment: 17 pages, 9 figures
Published: 2004
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19. Detector description and performance for the first coincidence observations between LIGO and GEO

Author: T. Etzel, H. Ward, I. Leonor, Walter Winkler, H. Tariq, P. Schwinberg, D. Webber, Harald Lück, M. MacInnis, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, D. Farnham, T. Regimbau, E. Black, Martin M. Fejer, J. R. Smith, R. Bork, Peter H. Sneddon, B. Lantz, A. Heptonstall, M. Malec, T. Nash, Roy Williams, K. Kawabe, M. Mageswaran, O. Matherny, J. H. Romie, A. Sazonov, V. Schmidt, R. Davies, R. Bennett, William E. Butler, K. Reithmaier, Andreas Freise, Matthew Pitkin, E. Rotthoff, Q. Z. Shu, A. Wilson, R. Wooley, Shinji Miyoki, C. Aulbert, I. Zawischa, J. A. Giaime, Robert J. McCarthy, Eric K. Gustafson, A. Marin, B. Bochner, Phil Willems, M. R. Smith, B. Barr, J. Worden, D. M. Strom, P. Ehrens, Albrecht Rüdiger, Martin P McHugh, Keisuke Goda, Massimo Tinto, Erik Katsavounidis, M. J. Lubinski, K. S. Ganezer, K. Watts, Stefan Goßler, Linqing Wen, Y. Hefetz, S. Roddy, S. Nagano, M. H. P. M. van Putten, S. Tilav, D. Redding, Peter Aufmuth, E. J. Daw, I. Salzman, Joseph D. Romano, Rana X. Adhikari, B. Machenschalk, K. Bayer, C. King, Adrian C. Ottewill, P. Hoang, N. Hepler, V. Chickarmane, R. Riesen, Roland Schilling, Vladimir B. Braginsky, C. A. Shapiro, K. Riles, A. Gillespie, Kasem Mossavi, R. M. S. Schofield, Albert Lazzarini, E. Maros, Timothy Evans, B. Bland-Weaver, K. T. Reilly, C. A. Cantley, Benjamin William Allen, R. Coldwell, Gerhard Heinzel, C. Hardham, Benno Willke, K. Mailand, Kevin C. Schlaufman, N. A. Robertson, H. Naundorf, Benjamin J. Owen, L. Jones, Krzysztof Belczynski, C. Gray, G. H. Sanders, R. Lawrence, Karsten Danzmann, M. C. Sumner, M. Lormand, D. Sigg, S. W. Ballmer, M. Fine, Bernard F. Whiting, R. Mittleman, L. Bogue, Nelson Christensen, Alessandra Buonanno, Yousuke Itoh, A. Chandler, Kevin M. Ryan, Richard J. Abbott, K. V. Tokmakov, Gianpietro Cagnoli, G. Moreno, A. Hartunian, B. Bhawal, S. Penn, Erika D'Ambrosio, S. Chatterji, H. Yamamoto, Laura Cadonati, S. Wise, A. J. Weinstein, V. V. Frolov, S. Grunewald, Badri Krishnan, Herbert Welling, Nergis Mavalvala, B. C. Barish, Richard Ingley, J. Zweizig, F. Asiri, J. G. Rollins, T. T. Lyons, H. Overmier, W. O. Hamilton, Kenneth D. Skeldon, Pamela J. Russell, S. Richman, Antony C. Searle, V. Leonhardt, T. Delker, R. DeSalvo, S. Killbourn, David Crooks, James Whelan, H. Ding, Sergey P. Vyatchanin, M. Landry, Scott Koranda, Oliver Jennrich, A. Bullington, D. Chin, Susan M. Scott, S. E. Whitcomb, Kenneth G. Libbrecht, Teviet Creighton, B. Mours, J. Betzwieser, D. B. Kozak, Stanislav Babak, J. Myers, Walid A. Majid, Herbert Walther, L. Matone, C. Vorvick, M. Schrempel, Kip S. Thorne, W. R. Johnston, S. J. Berukoff, Joseph M. Kovalik, Duncan A. Brown, K. Kötter, J. H. Hough, S. Brozek, Peter R. Saulson, Robert Spero, Soumya D. Mohanty, N. Zotov, R. Taylor, Douglas R. Cook, A. Rizzi, D. Ugolini, Carsten Fallnich, F. Raab, G. Mueller, K. Mason, Richard L. Savage, Michael E Zucker, S. Seel, J. Logan, R. K. Nayak, Brent Ware, C. Ebeling, Suvadeep Bose, Curt Cutler, M. Coles, M. Guenther, R. Rahkola, A. Grant, S. Liu, W. G. Anderson, V. P. Mitrofanov, Jeffrey A. Edlund, F. Nocera, Martin Hewitson, Kevin M. Carter, Alicia M. Sintes, Peter Shawhan, L. Zhang, G. Mendell, A. Sibley, Lindon J. Robison, R. Burgess, Alberto Vecchio, M. Tibbits, B. P. Abbott, S. B. Anderson, C. Colacino, M. C. Araya, T. Summerscales, Xavier Siemens, D. I. Robertson, Patrick Brady, David H. Shoemaker, S. Vass, David B. Tanner, Yi Chen, Helena Armandula, E. J. Elliffe, J. Heefner, Éanna É. Flanagan, R. Amin, M. Hennessy, M. W. Regehr, M. Hrynevych, S. Traeger, Marco Aurelio Diaz, C. Parameswariah, C. Barker-Patton, Peter Fritschel, U. Weiland, W. Kells, Kenneth A. Strain, A. Weidner, Gregory M. Harry, D. Busby, F. Mann, A. L. Stuver, M. Pedraza, Soma Mukherjee, M. Lei, J. Langdale, B. O'Reilly, N. Hindman, Maria Alessandra Papa, B. Sears, T. Olson, M. Fyffe, Gabriela Gonzalez, Michele Vallisneri, Ik Siong Heng, D. Rose, Kent Blackburn, S. Márka, G. Billingsley, D. Ouimette, G. Traylor, Vicky Kalogera, P. Csatorday, R. J. Dupuis, A. Khan, Thomas Corbitt, Akiteru Takamori, Sanichiro Yoshida, M. V. Plissi, J. Chapsky, J. Castiglione, P. Charlton, Graham Woan, Virginio Sannibale, Hartmut Grote, David E. McClelland, D. Barker, Robert L. Byer, D. Jungwirth, Philippe Grandclément, I. A. Bilenko, Ian Taylor, P. J. Sutton, Haisheng Rong, M. Rakhmanov, J. Mason, Morag M. Casey, P. E. Lindquist, David J. Ottaway, M. Heurs, B. J. Winjum, Bernard F. Schutz, Rainer Weiss, M. Ito, Seiji Kawamura, C. Messenger, G. Stapfer, R. W. P. Drever, P. Kloevekorn, J. Hanson, W. Hua, W. W. Johnson, S. Wen, Jordan Camp, A. S. Sengupta, G. Newton, Osamu Miyakawa, David H. Reitze, Christian J. Killow, Lee Samuel Finn, M. R. Pratt, Matthew Evans, L. Cardenas, S. Klimenko, R. Balasubramanian, M. Barnes, Julien Sylvestre, B. J. Cusack, P. McNamara, S. R. Rao, L. Wallace, R. Frey, R. Gustafson, P. J. King, D. Grimmett, Philip Nutzman, M. A. Barton, V. Parameswariah, D.B. DeBra, A. G. Wiseman, M. Hammond, Jolien D. E. Creighton, M. W.E. Smith, J. Kern, C. Torres, Chunglee Kim, D. C. Coyne, S. Dhurandar, A. Ivanov, H. Radkins, W. Tyler, I. Yakushin, Raymond G. Beausoleil, Guenakh Mitselmakher, L. Sievers, J. E. Brau, D. Churches, A. M. Gretarsson, Sheila Rowan, A. Ageev, C. I. Torrie, P. R. Williams, and S. Meshkov
Subjects: Physics, 010308 nuclear & particles physics, Gravitational wave, Detector, FOS: Physical sciences, Astronomy, General Relativity and Quantum Cosmology (gr-qc), General Medicine, Astrophysics, Interference (wave propagation), 01 natural sciences, General Relativity and Quantum Cosmology, LIGO, Coincidence, Interferometry, Observatory, 0103 physical sciences, 010306 general physics, QC, LIGO Scientific Collaboration
Abstract: For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data., 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial changes
Published: 2004

20. Analysis of First LIGO Science Data for Stochastic Gravitational Waves

Author: P. Ehrens, S. Traeger, Erika D'Ambrosio, Morag M. Casey, M. Heurs, B. J. Winjum, Timothy Evans, R. Coldwell, D. Sigg, S. W. Ballmer, G. Moreno, David H. Shoemaker, A. Gillespie, David Crooks, J. Logan, R. K. Nayak, N. Hindman, R. Amin, Alberto Vecchio, C. Barker-Patton, F. Mann, Peter Fritschel, Keisuke Goda, Erik Katsavounidis, S. Penn, Pamela J. Russell, S. Richman, Oliver Jennrich, E. Rotthoff, R. Rahkola, H. Ward, A. Ivanov, H. Radkins, S. P. Vyachanin, J. Betzwieser, B. Sears, Vicky Kalogera, M. J. Lubinski, M. A. Barton, W. Tyler, Szabolcs Marka, W. R. Johnston, Rana X. Adhikari, B. Machenschalk, R. Taylor, D. Ugolini, Carsten Fallnich, J. Kovalik, G. Mendell, F. Asiri, Kip S. Thorne, J. Chapsky, J. Heefner, Raymond G. Beausoleil, A. Rizzi, Gerhard Heinzel, C. Hardham, Benno Willke, D. Farnham, Robert Spero, Soumya D. Mohanty, N. Zotov, A. M. Gretarsson, Badri Krishnan, Antony C. Searle, D.B. DeBra, K. Mason, T. Summerscales, Gregory M. Harry, M. Lei, T. Olson, Sanjeev Dhurandhar, C. Parameswariah, Sheila Rowan, V. Schmidt, B. Mours, Lindon J. Robison, J. Mason, Vladimir B. Braginsky, K. Riles, R. Balasubramanian, Alessandra Buonanno, M. MacInnis, B. F. Whiting, L. Jones, A. Khan, V. P. Mitrofanov, Peter R. Saulson, Michael Landry, R. Davies, R. Bennett, William E. Butler, M. Hammond, U. Weiland, J. Langdale, M. Fyffe, C. Gray, M. C. Araya, Helena Armandula, Albrecht Rüdiger, Virginio Sannibale, M. Ito, Walter Winkler, Peter H. Sneddon, David E. McClelland, E. J. Elliffe, Harald Lück, G. Billingsley, Martin P McHugh, G. Traylor, M. R. Smith, M. H. P. M. van Putten, M. W.E. Smith, J. Kern, Thomas Corbitt, Albert Lazzarini, P. R. Williams, Sanichiro Yoshida, W. Hua, Gabriela Gonzalez, A. Ageev, Graham Woan, Robert L. Byer, Xavier Siemens, Adrian C. Ottewill, Yousuke Itoh, S. Tilav, Jolien D. E. Creighton, Michele Vallisneri, Michael E Zucker, Ik Siong Heng, C. A. Shapiro, M. Rakhmanov, Akiteru Takamori, J. E. Brau, K. Mailand, E. Maros, Krzysztof Belczynski, H. Overmier, B. Bland-Weaver, Bernard F. Schutz, Yi Chen, R. Mittleman, D. Churches, Nelson Christensen, M. Hennessy, Q. Z. Shu, A. Hartunian, Chunglee Kim, G. Stapfer, J. Hanson, A. L. Stuver, T. Etzel, B. Bochner, A. Wilson, Massimo Tinto, Guido Mueller, O. Matherny, R. J. Dupuis, A. Chandler, Laura Cadonati, D. Ouimette, J. H. Romie, K. Bayer, J. G. Rollins, Kevin M. Ryan, B. Barr, S. Nagano, B. Lantz, J. Worden, D. Redding, P. Schwinberg, R. DeSalvo, J. Castiglione, P. Charlton, F. J. Raab, V. Parameswariah, M. Coles, M. Guenther, Scott Koranda, L. Matone, Philippe Grandclément, S. Meshkov, P. J. Sutton, Haisheng Rong, I. Salzman, V. Leonhardt, D. Webber, K. Kawabe, R. Gustafson, T. Delker, Susan M. Scott, Teviet Creighton, V. Quetschke, Bangalore Suryanarayana Sathyaprakash, E. Black, H. Tariq, D. Jungwirth, P. Hoang, R. M. S. Schofield, Benjamin J. Owen, I. A. Bilenko, Ian Taylor, C. Torres, S. Chatterji, Shinji Miyoki, Herbert Walther, Martin M. Fejer, J. R. Smith, R. Bork, Marco Aurelio Diaz, M. Mageswaran, K. Reithmaier, T. Nash, A. Sibley, Andreas Freise, K. V. Tokmakov, David J. Ottaway, R. Riesen, K. Kötter, Matthew Pitkin, A. Sazonov, R. Wooley, N. Hepler, Patrick Brady, C. Messenger, J. Zweizig, C. A. Cantley, A. J. Weinstein, S. Brozek, Curt Cutler, G. H. Sanders, R. Lawrence, Richard L. Savage, D. B. Kozak, Robert J. McCarthy, Roland Schilling, C. Vorvick, Benjamin William Allen, I. Zawischa, Linqing Wen, F. Nocera, Martin Hewitson, C. Aulbert, P. Kloevekorn, Karsten Danzmann, M. C. Sumner, Seiji Kawamura, V. V. Frolov, J. A. Giaime, Eric K. Gustafson, T. Regimbau, Y. Hefetz, C. I. Torrie, A. Heptonstall, M. Malec, A. Grant, S. Liu, S. Wen, W. G. Anderson, Joseph D. Romano, D. Chin, C. King, Gianpietro Cagnoli, Phil Willems, Peter Shawhan, Jeffrey A. Edlund, M. Tibbits, B. P. Abbott, T. T. Lyons, L. Zhang, Kasem Mossavi, Osamu Miyakawa, David H. Reitze, Christian J. Killow, Stanislav Babak, Walid A. Majid, S. Vass, Duncan A. Brown, D. M. Strom, Richard J. Abbott, W. Kells, D. Busby, Brent Ware, R. Burgess, J. Myers, C. Ebeling, Suvadeep Bose, S. Wise, S. Grunewald, M. Hrynevych, D. I. Robertson, Kenneth G. Libbrecht, Roy Williams, K. S. Ganezer, K. Watts, S. E. Whitcomb, Stefan Goßler, K. T. Reilly, Kevin C. Schlaufman, Herbert Welling, Nergis Mavalvala, S. J. Berukoff, Kevin M. Carter, S. B. Anderson, David B. Tanner, M. W. Regehr, A. Marin, M. Pedraza, Maria Alessandra Papa, Kent Blackburn, N. A. Robertson, I. Leonor, E. J. Daw, D. Rose, Rainer Weiss, R. W. P. Drever, W. W. Johnson, M. Lormand, M. Fine, Richard Ingley, A. Bullington, M. Schrempel, L. Bogue, Jordan Camp, A. S. Sengupta, G. Newton, M. R. Pratt, Matthew Evans, L. Cardenas, S. Klimenko, C. Colacino, Kenneth A. Strain, A. Weidner, B. O'Reilly, Peter Aufmuth, V. Chickarmane, H. Naundorf, B. Bhawal, P. Csatorday, M. V. Plissi, Hartmut Grote, P. E. Lindquist, Soma Mukherjee, H. Yamamoto, W. O. Hamilton, Kenneth D. Skeldon, S. Killbourn, James Whelan, H. Ding, J. H. Hough, Douglas R. Cook, S. Seel, I. Yakushin, Guenakh Mitselmakher, Flanagan, L. Sievers, M. Barnes, Julien Sylvestre, P. McNamara, L. Wallace, R. Frey, P. J. King, D. Grimmett, Philip Nutzman, A. G. Wiseman, D. C. Coyne, D. Barker, S. Roddy, A. M. Sintes, Lee Samuel Finn, B. C. Barish, B. J. Cusack, S. R. Rao, and The LIGO Scientific Collaboration
Subjects: Nuclear and High Energy Physics, Gravitational-wave observatory, Frequency band, interferometer, FOS: Physical sciences, Astrophysics, General Relativity and Quantum Cosmology (gr-qc), 01 natural sciences, General Relativity and Quantum Cosmology, 0103 physical sciences, ddc:530, Limit (mathematics), 010306 general physics, QC, Physics, detector, 010308 nuclear & particles physics, Gravitational wave, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Spectral density, LIGO, laser, radiation, Interferometry, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, upper limit
Abstract: We present the analysis of between 50 and 100 hrs of coincident interferometric strain data used to search for and establish an upper limit on a stochastic background of gravitational radiation. These data come from the first LIGO science run, during which all three LIGO interferometers were operated over a 2-week period spanning August and September of 2002. The method of cross-correlating the outputs of two interferometers is used for analysis. We describe in detail practical signal processing issues that arise when working with real data, and we establish an observational upper limit on a f^{-3} power spectrum of gravitational waves. Our 90% confidence limit is Omega_0 h_{100}^2 < 23 in the frequency band 40 to 314 Hz, where h_{100} is the Hubble constant in units of 100 km/sec/Mpc and Omega_0 is the gravitational wave energy density per logarithmic frequency interval in units of the closure density. This limit is approximately 10^4 times better than the previous, broadband direct limit using interferometric detectors, and nearly 3 times better than the best narrow-band bar detector limit. As LIGO and other worldwide detectors improve in sensitivity and attain their design goals, the analysis procedures described here should lead to stochastic background sensitivity levels of astrophysical interest., 26 pages, 17 figures
Published: 2003
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21. LIGO optics: initial and advanced

Author: A. Alexandrovski, B. Bochner, Gary H. Sanders, Roger K. Route, Martin M. Fejer, W. Kells, Gregory M. Harry, G. Billingsley, J. H. Hough, Eric K. Gustafson, Sheila Rowan, Rainer Weiss, Albert Lazzarini, Nergis Mavalvala, Jordan Camp, Stanley L. Whitcomb, Exarhos, Gregory J., Guenther, Arthur H., Lewis, Keith L., Soileau, M. J., and Stolz, Christopher J.
Subjects: Physics, Interferometry, Birefringence, Optics, business.industry, Detector, Astronomical interferometer, Adaptive optics, business, LIGO
Abstract: The LIGO project has completed the installation of large fused silica optical components in the vacuum systems of its observatories. Commissioning work on the Hanford 2 km interferometer has determined an upper limit to the optics losses, allowing comparison with design and pre-installation testing. Planning and development of sapphire optics for the next generation, advanced LIGO detector is now underway, including polishability, optical homogeneity, absorption, and birefringence. The advanced optics development also includes research aimed at lowering coating loss.
Published: 2002

22. Advances in the identification of bacteria and yeast

Author: B, Bochner
Subjects: Gram-Negative Bacteria, Humans, Gram-Positive Bacteria, Microbiology
Published: 1993

23. 1034 CLINICAL OUTCOMES OF PRIMARY BLADDER CARCINOMA IN SITU IN A CONTEMPORARY SERIES

Author: D. Chade, S.F. Shariat, G. Godoy, C. Savage, A. Cronin, B. Bochner, S.M.D. Donat, H. Herr, and G. Dalbagni
Subjects: Urology
Published: 2010
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24. [Adoptive immunotherapy and metastasized cancer of the kidney. Regulator effects of interleukin-4 on tumor infiltrating lymphocytes (TIL)]

Author: C, Peyret, B, Bochner, T Y, Lee, C L, Tso, J B, Dekernion, and A, Belldegrun
Subjects: Lymphocytes, Tumor-Infiltrating, Phenotype, Tumor Cells, Cultured, Humans, Interleukin-2, Interleukin-4, Adenocarcinoma, Neoplasm Metastasis, Killer Cells, Lymphokine-Activated, Immunotherapy, Adoptive, Kidney Neoplasms, Lymphocyte Subsets
Abstract: Adoptive immunotherapy is a new therapeutic approach of the treatment of advanced renal cell cancer. Experimental studies have shown that the cells with the highest cytolytic activity are tumor infiltrating lymphocytes (TIL). The effects of interleukin-4 (IL-4) on the expansion, proliferation, phenotype and antitumor activity of TIL were studied. Cultures were obtained from three primary renal tumors and one group of tumor invaded, regional lymph nodes. IL-4 induced a significant increase in lymphocytes expansion and proliferation, but the response was dependent of the concurrent dose of IL-2 in culture. TIL grown in the presence of IL-4 significantly reduced the level of non specific, non MHC restricted antitumor activity while exhibiting no effect on the level of autologous killing. The effects of irradiated autologous tumor stimulation on TIL cultures were also evaluated. Addition of autologous tumor increased expansion and proliferation of all cultures and significantly enhanced levels of autologous killing. IL-4 and autologous tumor stimulation are effective growth factors when used in combination with a lose dose IL-2 regimen and may be of significant benefit in the expansion of TIL for clinical trials.
Published: 1991

25. Reply

Author: B BOCHNER
Subjects: Immunology, Immunology and Allergy
Published: 1992
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26. Ion Exchange Resin-Catalyzed Esterification of Salicylic Acid with Methanol

Author: S. M. Gerber, M. B. Bochner, W. R. Vieth, and A. J. Rodger
Subjects: chemistry.chemical_compound, chemistry, Biochemistry, General Engineering, Methanol, Ion-exchange resin, Salicylic acid, Nuclear chemistry, Catalysis
Published: 1965
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27. Increasing Life Expectancy in Patients with Genitourinary Malignancies: Impact of Treatment Burden on Disease Management and Quality of Life.

Author: St-Laurent MP, Bochner B, Catto J, Davies BJ, Fankhauser CD, Garg T, Hamilton-Reeves J, Master V, Jensen BT, Lauridsen SV, Wulff-Burchfield E, and Psutka SP
Abstract: Background and Objective: Treatment burden refers to the overall impact of medical treatments on a patient's well-being and daily life. Our objective is to evaluate the impact of treatment burden on quality of life (QoL) in patients with genitourinary (GU) malignancies, highlighting the importance of patient-reported outcomes (PROs) in clinical trials to inform treatment decisions and improve patient care., Methods: We conducted a narrative review of clinical trials focused on GU malignancy (prostate, bladder, and kidney) between January 2000 and June 2024, analyzing related PROs and findings regarding treatment burden., Key Findings and Limitations: Recent landmark clinical trials demonstrate significant improvements in overall survival across GU malignancies with novel therapies. However, the reporting of QoL outcomes in these trials is often inadequate, with many lacking comprehensive data or long-term impact. Current publications are increasingly evaluating treatment burden and its impact on patient well-being as a critical outcome, but most clinical trials to date have failed to assess treatment burden across key domains including financial, time and travel, and medication management., Conclusions and Clinical Implications: While advancements in treatment have extended longevity in patients with GU malignancies, the treatment burden associated with the receipt of novel agents and its implications for QoL remain inadequately uncharacterized., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2024
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28. Five-year quality-of-life assessment by urinary diversion type after pelvic Exenterations.

Author: Moufarrij S, Dagher C, Filippova OT, Zhou Q, Iasonos A, Abu-Rustum NR, Mueller JJ, Leitao MM, Sandhu J, Bochner B, Carter J, Chi DS, and Sonoda Y
Subjects: Humans, Female, Middle Aged, Retrospective Studies, Aged, Longitudinal Studies, Genital Neoplasms, Female surgery, Genital Neoplasms, Female psychology, Body Image psychology, Adult, Surveys and Questionnaires, Neoplasm Recurrence, Local psychology, Quality of Life, Urinary Diversion methods, Urinary Diversion psychology, Pelvic Exenteration methods, Pelvic Exenteration adverse effects, Pelvic Exenteration psychology
Abstract: Objective: To determine whether urinary diversion procedures performed at time of pelvic exenteration affect quality of life in patients with recurrent gynecologic malignancies., Methods: We performed a retrospective secondary longitudinal analysis of quality of life according to type of urinary diversion patients received. Participants completed a series of validated questionnaires at various time points. We allocated patients based on urinary diversion type to either the continent group (CD; 29 [55 %]) or noncontinent group (NCD; 24 [45 %])., Results: We noted a significant improvement in global health scores from baseline over time (time p = 0.027). Physical functioning scores showed a statistically significant difference over time (at 24 months: NCD, -4.3 [95 % CI, -14.1 to 5.4]; CD, 0.4 [95 % CI, -7.1 to 7.9]. p < 0.001). Social functioning scores were persistently higher for the CD vs NCD group at all time points but did not differ significantly between the groups at baseline (p = 0.75) or over time within the same group (time p = 0.122). Body image scores significantly decreased (reduced burden) over time for both groups (p = 0.044) and were consistently higher in the NCD vs CD group., Conclusions: Patients experienced a return to their baseline quality of life within a year of surgery. Clinicians should prioritize and improve identifying and discussing postoperative challenges such as changes in physical and social functioning and body image., Competing Interests: Declaration of competing interest Dr. Abu-Rustum reported grants or contracts paid to the institution from GRAIL. Dr. Leitao Jr. reported ad-hoc speaker fees from Intuitive Surgical, Inc.; and advisory board participation for Johnson & Johnson/Ethicon and Immunogen. Dr. Bochner reported consulting fees from Olympus. Dr. Carter reported grants from the Breast Cancer Research Foundation; consulting fees from Sprout; and speaker fees from MedCo. Dr. Chi reported speaker fees from AstraZeneca; advisory board participation for Verthermia Acquio and Biom ‘Up; and stock ownership for Doximity and BioNTech SE. No other disclosures were reported., (Copyright © 2024. Published by Elsevier Inc.)
Published: 2024
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29. Multiparametric MRI in Era of Artificial Intelligence for Bladder Cancer Therapies.

Author: Akin O, Lema-Dopico A, Paudyal R, Konar AS, Chenevert TL, Malyarenko D, Hadjiiski L, Al-Ahmadie H, Goh AC, Bochner B, Rosenberg J, Schwartz LH, and Shukla-Dave A
Abstract: This review focuses on the principles, applications, and performance of mpMRI for bladder imaging. Quantitative imaging biomarkers (QIBs) derived from mpMRI are increasingly used in oncological applications, including tumor staging, prognosis, and assessment of treatment response. To standardize mpMRI acquisition and interpretation, an expert panel developed the Vesical Imaging-Reporting and Data System (VI-RADS). Many studies confirm the standardization and high degree of inter-reader agreement to discriminate muscle invasiveness in bladder cancer, supporting VI-RADS implementation in routine clinical practice. The standard MRI sequences for VI-RADS scoring are anatomical imaging, including T 2 w images, and physiological imaging with diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI). Physiological QIBs derived from analysis of DW- and DCE-MRI data and radiomic image features extracted from mpMRI images play an important role in bladder cancer. The current development of AI tools for analyzing mpMRI data and their potential impact on bladder imaging are surveyed. AI architectures are often implemented based on convolutional neural networks (CNNs), focusing on narrow/specific tasks. The application of AI can substantially impact bladder imaging clinical workflows; for example, manual tumor segmentation, which demands high time commitment and has inter-reader variability, can be replaced by an autosegmentation tool. The use of mpMRI and AI is projected to drive the field toward the personalized management of bladder cancer patients.
Published: 2023
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30. Radical Cystectomy in the Treatment of Invasive Bladder Cancer: Long-Term Results in 1,054 Patients.

Author: Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, and Skinner D
Abstract: Purpose: To evaluate our long-term experience with patients treated uniformly with radical cystectomy and pelvic lymph node dissection for invasive bladder cancer and to describe the association of the primary bladder tumor stage and regional lymph node status with clinical outcomes., Patients and Methods: All patients undergoing radical cystectomy with bilateral pelvic iliac lymphadenectomy, with the intent to cure, for transitional-cell carcinoma of the bladder between July 1971 and December 1997, with or without adjuvant radiation or chemotherapy, were evaluated. The clinical course, pathologic characteristics, and long-term clinical outcomes were evaluated in this group of patients., Results: A total of 1,054 patients (843 men [80%] and 211 women) with a median age of 66 years (range, 22 to 93 years) were uniformly treated. Median follow-up was 10.2 years (range, 0 to 28 years). There were 27 (2.5%) perioperative deaths, with a total of 292 (28%) early complications. Overall recurrence-free survival at 5 and 10 years for the entire cohort was 68% and 66%, respectively. The 5- and 10-year recurrence-free survival for patients with organ-confined, lymph node-negative tumors was 92% and 86% for P0 disease, 91% and 89% for Pis, 79% and 74% for Pa, and 83% and 78% for P1 tumors, respectively. Patients with muscle invasive (P2 and P3a), lymph node-negative tumors had 89% and 87% and 78% and 76% 5- and 10-year recurrence-free survival, respectively. Patients with nonorgan-confined (P3b, P4), lymph node-negative tumors demonstrated a significantly higher probability of recurrence compared with those with organ-confined bladder cancers ( P < .001). The 5- and 10-year recurrence-free survival for P3b tumors was 62% and 61%, and for P4 tumors was 50% and 45% , respectively. A total of 246 patients (24%) had lymph node tumor involvement. The 5- and 10-year recurrence-free survival for these patients was 35%, and 34%, respectively, which was significantly lower than for patients without lymph node involvement ( P < .001). Patients could also be stratified by the number of lymph nodes involved and by the extent of the primary bladder tumor (p stage). Patients with fewer than five positive lymph nodes, and whose p stage was organ-confined had significantly improved survival rates. Bladder cancer recurred in 311 patients (30%) . The median time to recurrence among those patients in whom the cancer recurred was 12 months (range, 0.04 to 11.1 years). In 234 patients (22%) there was a distant recurrence, and in 77 patients (7%) there was a local (pelvic) recurrence., Conclusion: These data from a large group of patients support the aggressive surgical management of invasive bladder cancer. Excellent long-term survival can be achieved with a low incidence of pelvic recurrence.
Published: 2023
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31. Hypofractionated Radiation Therapy (Hypo-RT) for the Treatment of Localized Bladder Cancer.

Author: Moore A, Lobaugh SM, Zhang Z, Rosenberg JE, Iyer G, Teo MY, Bochner B, Donahue T, Nunez DA, Dreyfuss A, Gorovets D, Zelefsky MJ, and Kollmeier MA
Abstract: Background: Various radiotherapeutic regimens are used in the treatment of bladder cancer., Objective: We aimed to evaluate early toxicity and outcomes associated with hypofractionated radiation therapy (Hypo-RT), 55Gy in 20 fractions., Material and Methods: We identified 40 patients who received definitive Hypo-RT for localized bladder cancer. Most patients were men (62.5%), elderly (median age 82), had high Charlson Comorbidity Index score (median 7, range 4-9) and were nonsurgical candidates (80%). Sixty-eight percent had a macroscopically complete transurethral resection of bladder tumor (TURBT) and 33 patients (82.5%) received concurrent chemotherapy. Acute (< =3mo) and late (>3mo) toxicities were assessed according to CTCAE v4.0. Survival outcomes were estimated using the Kaplan-Meier method. Median follow up after Hypo-RT was 32 months (95% CI: 28-49 months)., Results: Overall rates of acute grade 2 genitourinary (GU) and gastrointestinal (GI) toxicities were 40% each, most commonly urinary frequency and diarrhea. Two cases of acute grade 3 GU/GI toxicity occurred. Late grade 2+ toxicity occurred in 3 patients (7.5%): 2 grade 2 GU and 1 grade 3 GI. Seventy-seven percent achieved a complete response (CR). Six patients (20%) developed disease recurrence at a median time of 9.1 months. The estimated 2-year DFS and 2-year DSS rate were 59% (95% CI, 45-78%) and 78% (95% CI, 65-93%), respectively. Receipt of concurrent chemotherapy ( p = 0.003) and achieving a CR ( p = 0.018) were univariably associated with improved DSS. Tis component was associated with worse DSS ( p = 0.015)., Conclusion: Hypo-RT had a favorable toxicity profile and encouraging cancer control outcomes in this mostly elderly and frail patient cohort., Competing Interests: Jonathan E. Rosenberg and Bernard Bochner are Editorial Board Members of this journal, but were not involved in the peer-review process nor had access to any information regarding its peer-review. Assaf Moore, Stephanie M. Lobaugh, Zhigang Zhang, Gopa Iyer, Min Yuen Teo, Timothy Donahue, David Aramburu Nunez, Alexandra Dreyfuss, Daniel Gorovets, Michael J. Zelefsky and Marisa A. Kollmeier report no perceived conflicts of interest relevant to the current work., (© 2023 – The authors. Published by IOS Press.)
Published: 2023
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32. Feasibility of a geriatric comanagement (GERICO) pilot program for patients 75 and older undergoing radical cystectomy.

Author: Letica-Kriegel AS, Tin AL, Nash GM, Benfante NE, McNeil N, Vickers AJ, Bochner B, Donat SM, Goh A, Dalbagni G, Donahue T, Cha EK, Pietzak E, Herr H, Korc-Grodzicki B, and Shahrokni A
Subjects: Aged, Cystectomy, Feasibility Studies, Female, Humans, Male, Pandemics, Pilot Projects, Prospective Studies, Retrospective Studies, COVID-19, Urinary Bladder Neoplasms surgery
Abstract: Background: Retrospective studies have shown the beneficial impact of geriatric comanagement (GERICO) on perioperative outcomes of older adults with cancer. We prospectively assessed the feasibility of perioperative GERICO for older adults with bladder cancer undergoing radical cystectomy., Methods: We conducted a pilot study wherein all patients 75 years and older undergoing radical cystectomy between October 2019 and November 2020 were referred to the Geriatric Service preoperatively. Feasibility was defined according to the percentage of patients who received preoperative evaluation by the Geriatrics Service, who were followed for more than 80% of their inpatient days and who had their surgery rescheduled for logistical reasons. Urology advanced practice provider (APP) satisfaction with the program was measured via an 11-item survey., Results: Sixty-six eligible patients underwent radical cystectomy in the stated time frame; 59 (89%; 95% confidence interval [CI], 79-97%) were referred to the Geriatric Service for evaluation. The median age of patients who had geriatric comanagement was 79 years; 40 (68%) were male. Forty-one patients (69%) were visited on at least 80% of the days in which they were not in the intensive care unit. No surgeries were rescheduled for logistical reasons. Nine of the 12 urology APPs (75%) responded to the survey; all nine "somewhat" or "strongly" agreed with statements indicating satisfaction with the program., Conclusion: Despite the challenges of the COVID-19 pandemic, we showed that perioperative GERICO is feasible. Fully powered prospective randomized controlled trials should be conducted to assess GERICO's impact on perioperative outcomes of older adults with cancer., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
Published: 2022
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33. Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients.

Author: Nguyen B, Fong C, Luthra A, Smith SA, DiNatale RG, Nandakumar S, Walch H, Chatila WK, Madupuri R, Kundra R, Bielski CM, Mastrogiacomo B, Donoghue MTA, Boire A, Chandarlapaty S, Ganesh K, Harding JJ, Iacobuzio-Donahue CA, Razavi P, Reznik E, Rudin CM, Zamarin D, Abida W, Abou-Alfa GK, Aghajanian C, Cercek A, Chi P, Feldman D, Ho AL, Iyer G, Janjigian YY, Morris M, Motzer RJ, O'Reilly EM, Postow MA, Raj NP, Riely GJ, Robson ME, Rosenberg JE, Safonov A, Shoushtari AN, Tap W, Teo MY, Varghese AM, Voss M, Yaeger R, Zauderer MG, Abu-Rustum N, Garcia-Aguilar J, Bochner B, Hakimi A, Jarnagin WR, Jones DR, Molena D, Morris L, Rios-Doria E, Russo P, Singer S, Strong VE, Chakravarty D, Ellenson LH, Gopalan A, Reis-Filho JS, Weigelt B, Ladanyi M, Gonen M, Shah SP, Massague J, Gao J, Zehir A, Berger MF, Solit DB, Bakhoum SF, Sanchez-Vega F, and Schultz N
Subjects: Cohort Studies, Female, Humans, Male, Organ Specificity genetics, Prospective Studies, Genomics, High-Throughput Nucleotide Sequencing, Neoplasm Metastasis genetics, Neoplasm Metastasis pathology
Abstract: Metastatic progression is the main cause of death in cancer patients, whereas the underlying genomic mechanisms driving metastasis remain largely unknown. Here, we assembled MSK-MET, a pan-cancer cohort of over 25,000 patients with metastatic diseases. By analyzing genomic and clinical data from this cohort, we identified associations between genomic alterations and patterns of metastatic dissemination across 50 tumor types. We found that chromosomal instability is strongly correlated with metastatic burden in some tumor types, including prostate adenocarcinoma, lung adenocarcinoma, and HR+/HER2+ breast ductal carcinoma, but not in others, including colorectal cancer and high-grade serous ovarian cancer, where copy-number alteration patterns may be established early in tumor development. We also identified somatic alterations associated with metastatic burden and specific target organs. Our data offer a valuable resource for the investigation of the biological basis for metastatic spread and highlight the complex role of chromosomal instability in cancer progression., Competing Interests: Declaration of interests S.C. receives consulting fees from Novartis, Lilly, and Sanofi and research funding from Daiichi-Sankyo and Paige.ai. J.J.H. receives consulting fees from Bristol Myers Squibb, Merck, Exelexis, Eisai, QED, Cytomx, Zymeworks, Adaptiimmune, and ImVax and research funding from Bristol Myers Squibb. C.A.I.-D. receives research funding from Bristol Myers Squibb. P. Razavi received consultation/Ad board/Honoraria from Novartis, Foundation Medicine, AstraZeneca, Epic Sciences, Inivata, Natera, and Tempus and institutional grant/funding from Grail, Illumina, Novartis, Epic Sciences, and ArcherDx. C.M.R. has consulted regarding oncology drug development with AbbVie, Amgen, Astra Zeneca, Epizyme, Genentech/Roche, Ipsen, Jazz, Lilly, and Syros and serves on the scientific advisory boards of Bridge Medicines, Earli, and Harpoon Therapeutics. D.Z. receives research funding from Astra Zeneca, Plexxikon, and Genentech and consulting fees from Merck, Synlogic Therapeutics, GSK, Bristol Myers Squibb, Genentech, Xencor, Memgen, Immunos, Agenus, Hookipa, Calidi, and Synthekine. B.W. has an ad hoc membership advisory board Repare Therapeutics. W.A. receives speaking honoraria from Roche, Medscape, Aptitude Health, and Clinical Education Alliance; consulting fees from Clovis Oncology, Janssen, ORIC pharmaceuticals, Daiichi Sankyo; and research funding from AstraZeneca, Zenith Epigenetics, Clovis Oncology, ORIC pharmaceuticals, and Epizyme. G.K.A.-A. receives research funding from Arcus, Agios, Astra Zeneca, Bayer, BioNtech, BMS, Celgene, Flatiron, Genentech/Roche, Genoscience, Incyte, Polaris, Puma, QED, Sillajen, and Yiviva and consulting fees from Adicet, Agios, Astra Zeneca, Alnylam, Autem, Bayer, Beigene, Berry Genomics, Cend, Celgene, CytomX, Eisai, Eli Lilly, Exelixis, Flatiron, Genentech/Roche, Genoscience, Helio, Incyte, Ipsen, Legend Biotech, Loxo, Merck, MINA, Nerviano, QED, Redhill, Rafael, Silenseed, Sillajen, Sobi, Surface Oncology, Therabionics, Twoxar, Vector, and Yiviva. E.M.O. receives research funding from Genentech/Roche, Celgene/BMS, BioNTech, BioAtla, AstraZeneca, Arcus, Elicio, Parker Institute, and AstraZeneca and consulting fees from Cytomx Therapeutics (DSMB), Rafael Therapeutics (DSMB), Sobi, Silenseed, Tyme, Seagen, Molecular Templates, Boehringer Ingelheim, BioNTech, Ipsen, Polaris, Merck, IDEAYA, Cend, AstraZeneca, Noxxon, BioSapien, Bayer (spouse), Genentech-Roche (spouse), Celgene-BMS (spouse), and Eisai (spouse). M.A.P. receive consulting fees from BMS, Merck, Array BioPharma, Novartis, Incyte, NewLink Genetics, Aduro, Eisai, and Pfizer; honoraria from BMS and Merck; research support from RGenix, Infinity, BMS, Merck, Array BioPharma, Novartis, and AstraZeneca. G.J.R. has institutional research funding from Mirait, Takeda, Merck, Roche, Novartis, and Pfizer. S.F.B. holds a patent related to some of the work described targeting CIN in advanced cancer. He owns equity in, receives compensation from, and serves as a consultant and the scientific advisory board and board of directors of Volastra Therapeutics Inc. A.N.S. has advisory board/personal fees from Bristol-Myers Squibb, Immunocore, and Castle Biosciences; research support from Bristol-Myers Squibb, Immunocore, Xcovery, Polaris, Novartis, Pfizer, and Checkmate Pharmaceuticals; and research funding from OBI-Pharma, GSK, Silenseed, BMS, and Lilly. R.Y. receives consulting fees from Array BioPharma/Pfizer, Mirati Therapeutics, and Natera and research funding from Pfizer and Boehringer Ingelheim. D.R.J. is member of the advisory council for Astra Zeneca and member of the Clinical Trial Steering Committee for Merck. D.M. reports disclosures from AstraZeneca, Johnson & Johnson, Boston Scientific, Bristol-Myers Squibb, and Merck. S.P.S. is shareholder and consultant for Canexia Health Inc. M.F.B receives consulting fees from Roche, Eli Lilly, and PetDx and research funding from Grail. D.B.S. has received consulted for and received honoraria from Pfizer, Lilly/Loxo Oncology, Vividion Therapeutics, Scorpion Therapetuics, and BridgeBio. B.N. is an employee of Loxo Oncology at Lilly., (Copyright © 2022 Elsevier Inc. All rights reserved.)
Published: 2022
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34. Definition of a Structured Training Curriculum for Robot-assisted Radical Cystectomy with Intracorporeal Ileal Conduit in Male Patients: A Delphi Consensus Study Led by the ERUS Educational Board.

Author: Dell'Oglio P, Turri F, Larcher A, D'Hondt F, Sanchez-Salas R, Bochner B, Palou J, Weston R, Hosseini A, Canda AE, Bjerggaard J, Cacciamani G, Olsen KØ, Gill I, Piechaud T, Artibani W, van Leeuwen PJ, Stenzl A, Kelly J, Dasgupta P, Wijburg C, Collins JW, Desai M, van der Poel HG, Montorsi F, Wiklund P, and Mottrie A
Subjects: Curriculum, Cystectomy methods, Delphi Technique, Humans, Male, Treatment Outcome, Robotic Surgical Procedures methods, Robotics, Urinary Bladder Neoplasms surgery, Urinary Diversion
Abstract: Robot-assisted radical cystectomy (RARC) continues to expand, and several surgeons start training for this complex procedure. This calls for the development of a structured training program, with the aim to improve patient safety during RARC learning curve. A modified Delphi consensus process was started to develop the curriculum structure. An online survey based on the available evidence was delivered to a panel of 28 experts in the field of RARC, selected according to surgical and research experience, and expertise in running training courses. Consensus was defined as ≥80% agreement between the responders. Overall, 96.4% experts completed the survey. The structure of the RARC curriculum was defined as follows: (1) theoretical training; (2) preclinical simulation-based training: 5-d simulation-based activity, using models with increasing complexity (ie, virtual reality, and dry- and wet-laboratory exercises), and nontechnical skills training session; (3) clinical training: modular console activity of at least 6 mo at the host center (a RARC case was divided into 11 steps and steps of similar complexity were grouped into five modules); and (4) final evaluation: blind review of a video-recorded RARC case. This structured training pathway will guide a starting surgeon from the first steps of RARC toward independent completion of a full procedure. Clinical implementation is urgently needed. PATIENT SUMMARY: Robot-assisted radical cystectomy (RARC) is a complex procedure. The first structured training program for RARC was developed with the goal of aiding surgeons to overcome the learning curve of this procedure, improving patients' safety at the same time., (Copyright © 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Published: 2022
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35. Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference.

Author: Gotlib J, George TI, Carter MC, Austen KF, Bochner B, Dwyer DF, Lyons JJ, Hamilton MJ, Butterfield J, Bonadonna P, Weiler C, Galli SJ, Schwartz LB, Elberink HO, Maitland A, Theoharides T, Ustun C, Horny HP, Orfao A, Deininger M, Radia D, Jawhar M, Kluin-Nelemans H, Metcalfe DD, Arock M, Sperr WR, Valent P, Castells M, and Akin C
Subjects: Disease Management, Disease Susceptibility, Humans, Mastocytosis complications, Research, Translational Research, Biomedical, Mastocytosis diagnosis, Mastocytosis etiology, Mastocytosis therapy
Abstract: The American Initiative in Mast Cell Diseases (AIM) held its inaugural investigator conference at Stanford University School of Medicine in May 2019. The overarching goal of this meeting was to establish a Pan-American organization of physicians and scientists with multidisciplinary expertise in mast cell disease. To serve this unmet need, AIM envisions a network where basic, translational, and clinical researchers could establish collaborations with both academia and biopharma to support the development of new diagnostic methods, enhanced understanding of the biology of mast cells in human health and disease, and the testing of novel therapies. In these AIM proceedings, we highlight selected topics relevant to mast cell biology and provide updates regarding the recently described hereditary alpha-tryptasemia. In addition, we discuss the evaluation and treatment of mast cell activation (syndromes), allergy and anaphylaxis in mast cell disorders, and the clinical and biologic heterogeneity of the more indolent forms of mastocytosis. Because mast cell disorders are relatively rare, AIM hopes to achieve a coordination of scientific efforts not only in the Americas but also in Europe by collaborating with the well-established European Competence Network on Mastocytosis., (Copyright © 2021 American Academy of Allergy, Asthma & Immunology. All rights reserved.)
Published: 2021
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36. Electronic Rapid Fitness Assessment Identifies Factors Associated with Adverse Early Postoperative Outcomes following Radical Cystectomy.

Author: Chesnut GT, Tin AL, Sjoberg DD, Jang B, Benfante N, Sarraf S, Herr H, Donat SM, Dalbagni G, Bochner B, Shahrokni A, and Goh AC
Subjects: Aged, Aged, 80 and over, Digital Technology, Female, Humans, Male, Preoperative Period, Prospective Studies, Time Factors, Cystectomy methods, Geriatric Assessment methods, Postoperative Complications epidemiology, Urinary Bladder Neoplasms surgery
Abstract: Purpose: Frailty is associated with adverse outcomes following radical cystectomy. Prospective tools to identify factors affecting outcomes are needed. We describe a novel electronic rapid fitness assessment to evaluate geriatric patients undergoing radical cystectomy., Materials and Methods: Before undergoing radical cystectomy between February 2015 and February 2018, 80 patients older than age 75 years completed the electronic rapid fitness assessment and were perioperatively comanaged by the Geriatrics Service. Physical function and cognitive function over 12 domains were evaluated and an accumulated geriatric deficit score was compiled. Hospital length of stay, discharge disposition, unplanned intensive care unit admissions, urgent care visits, readmissions, complications and deaths were assessed., Results: A total of 65 patients who underwent radical cystectomy for bladder cancer without concomitant procedures completed the assessment. Median age was 80 (77, 84) years and 52 (80%) were male. A higher proportion of patients with intensive care unit admission, urgent care visit and major complications had impairments identified within electronic rapid fitness assessment domains, including Timed Up and Go. Readmission rates were similar between patients with or without deficits identified. Higher accumulated geriatric deficit score was significantly associated with intensive care unit admission (p=0.035), death within 90 days (p=0.037) and discharge to other than home (p=0.0002)., Conclusions: We demonstrated the feasibility of assessing fitness in patients older than 75 years undergoing radical cystectomy using a novel electronic fitness tool. Physical limitations and overall impairment corresponded to higher intensive care unit admission rates and adverse postoperative outcomes. Larger studies in less resourced environments are required to validate these findings.
Published: 2021
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37. Predictors of Benign Ureteroenteric Anastomotic Strictures After Radical Cystectomy and Urinary Diversion.

Author: Amin KA, Vertosick EA, Stearns G, Fathollahi A, Sjoberg DD, Donat MS, Herr H, Bochner B, Dalbagni G, and Sandhu JS
Subjects: Aged, Anastomosis, Surgical, Cohort Studies, Constriction, Pathologic epidemiology, Female, Humans, Incidence, Male, Middle Aged, Prognosis, Cystectomy methods, Ileum surgery, Postoperative Complications epidemiology, Ureter surgery, Urinary Bladder Neoplasms surgery, Urinary Diversion
Abstract: Objective: To determine predictors of symptomatic ureteroenteric anastomotic strictures (UAS) formation following radical cystectomy (RC) and urinary diversion (UD)., Materials and Methods: A total of 2,888 consecutive patients who underwent open RC at our institution from 1995 to 2014 were included for analysis. Data were collected from institutional databases and individual medical records. Symptomatic benign UAS was defined as percutaneous nephrostomy tube insertion for rising creatinine or unilateral hydronephrosis by comparing preoperative and postoperative imaging. Univariate and multivariable Cox proportional hazards models were utilized to identify features associated with UAS formation., Results: UAS developed in 123 of 2888 patients following RC. There were 94 symptomatic and 29 asymptomatic strictures. Median follow-up was 32 months (IQR 12, 72) for patients without stricture. Higher BMI (P = 0.002), ASA score >2 (P < 0.0001), lymph node positive disease (P = 0.027), and 30-day postoperative grade 3I+ complications (P = 0.017) on univariate analysis and male gender on multivariable analysis were significantly associated with time to stricture development. However, history of prior abdominal surgery (PAS) had the strongest association with time to stricture formation (HR 3.25, 95% CI 1.78, 5.94, P = 0.0001). Risk of developing a stricture within 10 years was 1.9% for patients without PAS vs 9.3% with PAS., Conclusion: Associated factors with an increased risk of benign UAS include higher BMI, ASA score >2, lymph node involvement, grade 3/4 complications within 30 days, male sex, and a history of PAS. We conclude that while surveillance is important for patients who undergo cystectomy for malignancy, it may be beneficial for patients with history of PAS to undergo more intensive follow-up compared to those patients without history of PAS., (Copyright © 2018. Published by Elsevier Inc.)
Published: 2020
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38. Transurethral Resection of Bladder Tumour: The Neglected Procedure in the Technology Race in Bladder Cancer.

Author: Mostafid H, Babjuk M, Bochner B, Lerner SP, Witjes F, Palou J, Roupret M, Shariat S, Gontero P, van Rhijn B, Zigeuner R, Sylvester R, Comperat E, Burger M, Malavaud B, Soloway M, Williams S, Black P, Daneshmand S, Steinberg G, Brausi M, Catto J, and Kamat AM
Subjects: Biomedical Technology, Humans, Urethra, Cystectomy methods, Urinary Bladder Neoplasms surgery
Abstract: Transurethral resection of bladder tumour is the initial, most critical step in the management of bladder cancer; as such, this is a call to arms for the urological community to it the due diligence it deserves regarding technology and training., (Copyright © 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Published: 2020
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39. Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Author: Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, Srinivasan P, Gao J, Chakravarty D, Devlin SM, Hellmann MD, Barron DA, Schram AM, Hameed M, Dogan S, Ross DS, Hechtman JF, DeLair DF, Yao J, Mandelker DL, Cheng DT, Chandramohan R, Mohanty AS, Ptashkin RN, Jayakumaran G, Prasad M, Syed MH, Rema AB, Liu ZY, Nafa K, Borsu L, Sadowska J, Casanova J, Bacares R, Kiecka IJ, Razumova A, Son JB, Stewart L, Baldi T, Mullaney KA, Al-Ahmadie H, Vakiani E, Abeshouse AA, Penson AV, Jonsson P, Camacho N, Chang MT, Won HH, Gross BE, Kundra R, Heins ZJ, Chen HW, Phillips S, Zhang H, Wang J, Ochoa A, Wills J, Eubank M, Thomas SB, Gardos SM, Reales DN, Galle J, Durany R, Cambria R, Abida W, Cercek A, Feldman DR, Gounder MM, Hakimi AA, Harding JJ, Iyer G, Janjigian YY, Jordan EJ, Kelly CM, Lowery MA, Morris LGT, Omuro AM, Raj N, Razavi P, Shoushtari AN, Shukla N, Soumerai TE, Varghese AM, Yaeger R, Coleman J, Bochner B, Riely GJ, Saltz LB, Scher HI, Sabbatini PJ, Robson ME, Klimstra DS, Taylor BS, Baselga J, Schultz N, Hyman DM, Arcila ME, Solit DB, Ladanyi M, and Berger MF
Published: 2017
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40. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Author: Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, Srinivasan P, Gao J, Chakravarty D, Devlin SM, Hellmann MD, Barron DA, Schram AM, Hameed M, Dogan S, Ross DS, Hechtman JF, DeLair DF, Yao J, Mandelker DL, Cheng DT, Chandramohan R, Mohanty AS, Ptashkin RN, Jayakumaran G, Prasad M, Syed MH, Rema AB, Liu ZY, Nafa K, Borsu L, Sadowska J, Casanova J, Bacares R, Kiecka IJ, Razumova A, Son JB, Stewart L, Baldi T, Mullaney KA, Al-Ahmadie H, Vakiani E, Abeshouse AA, Penson AV, Jonsson P, Camacho N, Chang MT, Won HH, Gross BE, Kundra R, Heins ZJ, Chen HW, Phillips S, Zhang H, Wang J, Ochoa A, Wills J, Eubank M, Thomas SB, Gardos SM, Reales DN, Galle J, Durany R, Cambria R, Abida W, Cercek A, Feldman DR, Gounder MM, Hakimi AA, Harding JJ, Iyer G, Janjigian YY, Jordan EJ, Kelly CM, Lowery MA, Morris LGT, Omuro AM, Raj N, Razavi P, Shoushtari AN, Shukla N, Soumerai TE, Varghese AM, Yaeger R, Coleman J, Bochner B, Riely GJ, Saltz LB, Scher HI, Sabbatini PJ, Robson ME, Klimstra DS, Taylor BS, Baselga J, Schultz N, Hyman DM, Arcila ME, Solit DB, Ladanyi M, and Berger MF
Subjects: Cohort Studies, Data Mining, Feasibility Studies, Female, Genomics, High-Throughput Nucleotide Sequencing, Humans, Male, Mutation, Neoplasms pathology, Prospective Studies, Sequence Analysis, DNA, Biomarkers, Tumor genetics, DNA, Neoplasm genetics, Neoplasm Metastasis genetics, Neoplasms genetics
Abstract: Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined tumor types, coupled with an expanding portfolio of molecularly targeted therapies, demands flexible and comprehensive approaches to profile clinically relevant genes across the full spectrum of cancers. We established a large-scale, prospective clinical sequencing initiative using a comprehensive assay, MSK-IMPACT, through which we have compiled tumor and matched normal sequence data from a unique cohort of more than 10,000 patients with advanced cancer and available pathological and clinical annotations. Using these data, we identified clinically relevant somatic mutations, novel noncoding alterations, and mutational signatures that were shared by common and rare tumor types. Patients were enrolled on genomically matched clinical trials at a rate of 11%. To enable discovery of novel biomarkers and deeper investigation into rare alterations and tumor types, all results are publicly accessible.
Published: 2017
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41. A 10-Item Checklist Improves Reporting of Critical Procedural Elements during Transurethral Resection of Bladder Tumor.

Author: Anderson C, Weber R, Patel D, Lowrance W, Mellis A, Cookson M, Lang M, Barocas D, Chang S, Newberger E, Montgomery JS, Weizer AZ, Lee CT, Kava BR, Jackson M, Meraney A, Sjoberg D, Bochner B, Dalbagni G, Donat M, and Herr H
Subjects: Female, Humans, Male, Retrospective Studies, Urologic Surgical Procedures statistics & numerical data, Checklist statistics & numerical data, Cystectomy methods, Natural Orifice Endoscopic Surgery methods, Quality Improvement, Research Report, Urinary Bladder Neoplasms surgery, Urologic Surgical Procedures methods
Abstract: Purpose: Previous studies have demonstrated significant variation in recurrence rates after transurethral resection of bladder tumor, likely due to differences in surgical quality. We sought to create a framework to define, measure and improve the quality of transurethral resection of bladder tumor using a surgical checklist., Materials and Methods: We formed a multi-institutional group of urologists with expertise with bladder cancer and identified 10 critical items that should be performed during every high quality transurethral bladder tumor resection. We prospectively implemented a 10-item checklist into practice and reviewed the operative reports of such resections performed before and after implementation. Results at all institutions were combined in a meta-analysis to estimate the overall change in the mean number of items documented., Results: The operative notes for 325 transurethral bladder tumor resections during checklist use were compared to those for 428 performed before checklist implementation. Checklist use increased the mean number of items reported from 4.8 to 8.0 per resection, resulting in a mean increase of 3.3 items (95% CI 1.9-4.7) on meta-analysis. With the checklist the percentage of reports that included all 10 items increased from 0.5% to 27% (p <0.0001). Surgeons who reported more checklist items tended to have a slightly higher proportion of biopsies containing muscle, although not at conventional significance (p = 0.062)., Conclusions: The use of a 10-item checklist during transurethral resection of bladder tumor improved the reporting of critical procedural elements. Although there was no clear impact on the inclusion of muscle in the specimen, checklist use may enhance surgeon attention to important aspects of the procedure and be a lever for quality improvement., (Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
Published: 2016
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42. Enhanced Recovery after Urological Surgery: A Contemporary Systematic Review of Outcomes, Key Elements, and Research Needs.

Author: Azhar RA, Bochner B, Catto J, Goh AC, Kelly J, Patel HD, Pruthi RS, Thalmann GN, and Desai M
Subjects: Diet, Early Ambulation, Postoperative Complications prevention & control, Recovery of Function, Smoking Cessation, Time Factors, Perioperative Care methods, Urologic Surgical Procedures
Abstract: Context: Enhanced Recovery after Surgery (ERAS) programs are multimodal care pathways that aim to decrease intra-operative blood loss, decrease postoperative complications, and reduce recovery times., Objective: To overview the use and key elements of ERAS pathways, and define needs for future clinical trials., Evidence Acquisition: A comprehensive systematic MEDLINE search was performed for English language reports published before May 2015 using the terms "postoperative period," "postoperative care," "enhanced recovery after surgery," "enhanced recovery," "accelerated recovery," "fast track recovery," "recovery program," "recovery pathway", "ERAS," and "urology" or "cystectomy" or "urologic surgery.", Evidence Synthesis: We identified 18 eligible articles. Patient counseling, physical conditioning, avoiding excessive alcohol and smoking, and good nutrition appeared to protect against postoperative complications. Fasting from solid food for only 6h and perioperative liquid-carbohydrate loading up to 2h prior to surgery appeared to be safe and reduced recovery times. Restricted, balanced, and goal-directed fluid replacement is effective when individualized, depending on patient morbidity and surgical procedure. Decreased intraoperative blood loss may be achieved by several measures. Deep vein thrombosis prophylaxis, antibiotic prophylaxis, and thermoregulation were found to help reduce postsurgical complications, as was a multimodal approach to postoperative nausea, vomiting, and analgesia. Chewing gum, prokinetic agents, oral laxatives, and an early resumption to normal diet appear to aid faster return to normal bowel function. Further studies should compare anesthetic protocols, refine analgesia, and evaluate the importance of robot-assisted surgery and the need/timing for drains and catheters., Conclusions: ERAS regimens are multidisciplinary, multimodal pathways that optimize postoperative recovery., Patient Summary: This review provides an overview of the use and key elements of Enhanced Recovery after Surgery programs, which are multimodal, multidisciplinary care pathways that aim to optimize postoperative recovery. Additional conclusions include identifying effective procedures within Enhanced Recovery after Surgery programs and defining needs for future clinical trials., (Copyright © 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Published: 2016
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43. Quality of life and symptom assessment in randomized clinical trials of bladder cancer: A systematic review.

Author: Feuerstein MA, Jacobs M, Piciocchi A, Bochner B, Pusic A, Fayers P, Blazeby J, and Efficace F
Subjects: Clinical Decision-Making, Humans, Self Report, Treatment Outcome, Clinical Trials as Topic methods, Quality of Life psychology, Urinary Bladder Neoplasms diagnosis, Urinary Bladder Neoplasms psychology
Abstract: Objectives: Patient-reported outcomes (PRO) help patients, caretakers, clinicians, and policy makers make informed decisions regarding treatment effectiveness. Our objective was to assess the quality of PRO reporting and methodological strengths and weaknesses in randomized controlled trials (RCT) in bladder cancer., Methods: A systematic literature search of bladder cancer RCT published between January 2004 and March 2014 was performed. Relevant studies were evaluated using a predetermined extraction form that included trial demographics, clinical and PRO characteristics, and standards of PRO reporting based on recommendations of the International Society for Quality of Life Research., Results: In total, 9 RCTs enrolling 1,237 patients were evaluated. All studies were in patients with nonmetastatic disease. In 5 RCTs, a PRO was the primary end point. Most RCTs did not report the mode of administration of the PRO instrument or the methods of collecting data. No RCT addressed the statistical approaches for missing data., Conclusions: We found that few RCTs in bladder cancer report PRO as an outcome. Efforts to expand PRO reporting to more RCTs and improve the quality of PRO reporting according to recognized standards are necessary for facilitating clinical decision making., (Copyright © 2015 Elsevier Inc. All rights reserved.)
Published: 2015
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44. Systematic review and cumulative analysis of oncologic and functional outcomes after robot-assisted radical cystectomy.

Author: Yuh B, Wilson T, Bochner B, Chan K, Palou J, Stenzl A, Montorsi F, Thalmann G, Guru K, Catto JW, Wiklund PN, and Novara G
Subjects: Chemotherapy, Adjuvant, Chi-Square Distribution, Disease Progression, Disease-Free Survival, Humans, Lymph Node Excision, Lymphatic Metastasis, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Neoplasm, Residual, Odds Ratio, Postoperative Complications etiology, Risk Factors, Time Factors, Treatment Outcome, Urinary Bladder Neoplasms mortality, Urinary Bladder Neoplasms pathology, Cystectomy adverse effects, Cystectomy mortality, Robotic Surgical Procedures adverse effects, Robotic Surgical Procedures mortality, Urinary Bladder Neoplasms surgery
Abstract: Context: Although open radical cystectomy (ORC) is still the standard approach, laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) are increasingly performed., Objective: To report on a systematic literature review and cumulative analysis of pathologic, oncologic, and functional outcomes of RARC in comparison with ORC and LRC., Evidence Acquisition: Medline, Scopus, and Web of Science databases were searched using a free-text protocol including the terms robot-assisted radical cystectomy or da Vinci radical cystectomy or robot* radical cystectomy. RARC case series and studies comparing RARC with either ORC or LRC were collected. A cumulative analysis was conducted., Evidence Synthesis: The searches retrieved 105 papers, 87 of which reported on pathologic, oncologic, or functional outcomes. Most series were retrospective and had small case numbers, short follow-up, and potential patient selection bias. The lymph node yield during lymph node dissection was 19 (range: 3-55), with half of the series following an extended template (yield range: 11-55). The lymph node-positive rate was 22%. The performance of lymphadenectomy was correlated with surgeon and institutional volume. Cumulative analyses showed no significant difference in lymph node yield between RARC and ORC. Positive surgical margin (PSM) rates were 5.6% (1-1.5% in pT2 disease and 0-25% in pT3 and higher disease). PSM rates did not appear to decrease with sequential case numbers. Cumulative analyses showed no significant difference in rates of surgical margins between RARC and ORC or RARC and LRC. Neoadjuvant chemotherapy use ranged from 0% to 31%, with adjuvant chemotherapy used in 4-29% of patients. Only six series reported a mean follow-up of >36 mo. Three-year disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) rates were 67-76%, 68-83%, and 61-80%, respectively. The 5-yr DFS, CSS, and OS rates were 53-74%, 66-80%, and 39-66%, respectively. Similar to ORC, disease of higher pathologic stage or evidence of lymph node involvement was associated with worse survival. Very limited data were available with respect to functional outcomes. The 12-mo continence rates with continent diversion were 83-100% in men for daytime continence and 66-76% for nighttime continence. In one series, potency was recovered in 63% of patients who were evaluable at 12 mo., Conclusions: Oncologic and functional data from RARC remain immature, and longer-term prospective studies are needed. Cumulative analyses demonstrated that lymph node yields and PSM rates were similar between RARC and ORC. Conclusive long-term survival outcomes for RARC were limited, although oncologic outcomes up to 5 yr were similar to those reported for ORC., Patient Summary: Although open radical cystectomy (RC) is still regarded as the standard treatment for muscle-invasive bladder cancer, laparoscopic and robot-assisted RCs are becoming more popular. Templates of lymph node dissection, lymph node yields, and positive surgical margin rates are acceptable with robot-assisted RC. Although definitive comparisons with open RC with respect to oncologic or functional outcomes are lacking, early results appear comparable., (Copyright © 2014 European Association of Urology. Published by Elsevier B.V. All rights reserved.)
Published: 2015
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45. Urinary diversion after radical cystectomy for bladder cancer: options, patient selection, and outcomes.

Author: Lee RK, Abol-Enein H, Artibani W, Bochner B, Dalbagni G, Daneshmand S, Fradet Y, Hautmann RE, Lee CT, Lerner SP, Pycha A, Sievert KD, Stenzl A, Thalmann G, and Shariat SF
Subjects: Female, Humans, Male, Peer Review, Postoperative Complications pathology, Quality of Life, Treatment Outcome, Urinary Bladder Neoplasms pathology, Urinary Reservoirs, Continent, Cystectomy methods, Patient Selection, Postoperative Complications surgery, Urinary Bladder Neoplasms surgery, Urinary Diversion methods
Abstract: Context: The urinary reconstructive options available after radical cystectomy (RC) for bladder cancer are discussed, as are the criteria for selection of the most appropriate diversion, and the outcomes and complications associated with different diversion options., Objective: To critically review the peer-reviewed literature on the function and oncological outcomes, complications, and factors influencing choice of procedure with urinary diversion after RC for bladder carcinoma., Evidence Acquisition: A Medline search was conducted to identify original articles, review articles, and editorials on urinary diversion in patients treated with RC. Searches were limited to the English language. Keywords included: 'bladder cancer', 'cystectomy', 'diversion', 'neobladder', and 'conduit'. The articles with the highest level of evidence were selected and reviewed, with the consensus of all of the authors of this paper., Evidence Synthesis: Both continent and incontinent diversions are available for urinary reconstruction after RC. In appropriately selected patients, an orthotopic neobladder permits the elimination of an external stoma and preservation of body image without compromising cancer control. However, the patient must be fully educated and committed to the labour-intensive rehabilitation process. He must also be able to perform self-catheterisation if necessary. When involvement of the urinary outflow tract by tumour prevents the use of an orthotopic neobladder, a continent cutaneous reservoir may still offer the opportunity for continence albeit one that requires obligate self-catheterisation. For patients who are not candidates for continent diversion, the ileal loop remains an acceptable and reliable option., Conclusions: Both continent and incontinent diversions are available for urinary reconstruction after RC. Orthotopic neobladders optimally preserve body image, while continent cutaneous diversions represent a reasonable alternative. Ileal conduits represent the fastest, easiest, least complication-prone, and most commonly performed urinary diversion., (© 2013 BJU International.)
Published: 2014
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46. Who should be included in a clinical trial of screening for bladder cancer?: a decision analysis of data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

Author: Vickers AJ, Bennette C, Kibel AS, Black A, Izmirlian G, Stephenson AJ, and Bochner B
Subjects: Aged, Female, Humans, Male, Middle Aged, Risk Factors, Clinical Trials as Topic, Decision Support Techniques, Early Detection of Cancer, Patient Selection, Urinary Bladder Neoplasms diagnosis
Abstract: Background: Because of its relatively low incidence, bladder cancer screening might have a better ratio of benefits to harms if it is restricted to a high-risk population. Data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial were used and simple decision analytic techniques were applied to compare different eligibility criteria for a screening trial., Methods: For a variety of possible eligibility criteria, the percentage of the population aged 55 years to 74 years and classified as being at high risk for developing invasive or high-grade carcinoma, and therefore likely to benefit from screening, was calculated. Regression models were used to calculate a risk score based on age, sex, smoking history, and family history of bladder cancer. The reduction in cases was calculated given hypothetical risk reductions associated with screening. The trade-off between patients screened and tumors avoided was calculated as a net benefit., Results: The 5-year probability of being diagnosed with invasive bladder cancer was 0.24%. Using a risk score > 6 or > 8 as the eligibility criterion for a trial was generally superior to including all older adults. In a typical scenario, a risk score > 6 would result in approximately 25% of the population being screened to prevent 57 invasive or high-grade bladder cancers per 100,000 population; screening the entire population would prevent only an additional 38 cases., Conclusions: Screening for bladder cancer can be optimized by restricting it to a subgroup of patients considered to be at elevated risk. Different eligibility criteria for a screening trial can be compared rationally using decision-analytic techniques., (Copyright © 2012 American Cancer Society.)
Published: 2013
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47. Genome sequencing identifies a basis for everolimus sensitivity.

Author: Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, and Solit DB
Subjects: Clinical Trials, Phase II as Topic, Codon, Nonsense, Disease-Free Survival, Everolimus, Genome, Human, Genome-Wide Association Study, Humans, Mechanistic Target of Rapamycin Complex 1, Molecular Targeted Therapy, Multiprotein Complexes, Neoplasm Metastasis, Neurofibromin 2 genetics, Proteins antagonists & inhibitors, Sequence Deletion, Sirolimus therapeutic use, TOR Serine-Threonine Kinases, Tuberous Sclerosis Complex 1 Protein, Urinary Bladder Neoplasms genetics, Urinary Bladder Neoplasms pathology, Antineoplastic Agents therapeutic use, Drug Resistance, Neoplasm genetics, Sirolimus analogs & derivatives, Tumor Suppressor Proteins genetics, Urinary Bladder Neoplasms drug therapy
Abstract: Cancer drugs often induce dramatic responses in a small minority of patients. We used whole-genome sequencing to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a drug that inhibits the mTOR (mammalian target of rapamycin) signaling pathway. Among the somatic mutations was a loss-of-function mutation in TSC1 (tuberous sclerosis complex 1), a regulator of mTOR pathway activation. Targeted sequencing revealed TSC1 mutations in about 8% of 109 additional bladder cancers examined, and TSC1 mutation correlated with everolimus sensitivity. These results demonstrate the feasibility of using whole-genome sequencing in the clinical setting to identify previously occult biomarkers of drug sensitivity that can aid in the identification of patients most likely to respond to targeted anticancer drugs.
Published: 2012
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48. Davos declaration: allergy as a global problem.

Author: Ring J, Akdis C, Behrendt H, Lauener RP, Schäppi G, Akdis M, Ammann W, de Beaumont O, Bieber T, Bienenstock J, Blaser K, Bochner B, Bousquet J, Crameri R, Custovic A, Czerkinsky C, Darsow U, Denburg J, Drazen J, de Villiers EM, Fire A, Galli S, Haahtela T, zur Hausen H, Hildemann S, Holgate S, Holt P, Jakob T, Jung A, Kemeny M, Koren H, Leung D, Lockey R, Marone G, Mempel M, Menné B, Menz G, Mueller U, von Mutius E, Ollert M, O'Mahony L, Pawankar R, Renz H, Platts-Mills T, Roduit C, Schmidt-Weber C, Traidl-Hoffmann C, Wahn U, and Rietschel E
Subjects: Humans, Global Health, Hypersensitivity
Published: 2012
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49. Advances in mechanisms of asthma, allergy, and immunology in 2011.

Author: Boyce JA, Bochner B, Finkelman FD, and Rothenberg ME
Subjects: Allergy and Immunology, Animals, Cytokines immunology, Disease Susceptibility, Humans, Immunoglobulin E immunology, Immunotherapy, Asthma diagnosis, Asthma immunology, Asthma therapy, Hypersensitivity diagnosis, Hypersensitivity immunology, Hypersensitivity therapy
Abstract: 2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T(H)17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review., (Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)
Published: 2012
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50. Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma.

Author: Al-Ahmadie HA, Iyer G, Janakiraman M, Lin O, Heguy A, Tickoo SK, Fine SW, Gopalan A, Chen YB, Balar A, Riches J, Bochner B, Dalbagni G, Bajorin DF, Reuter VE, Milowsky MI, and Solit DB
Subjects: Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Proteins genetics, Prognosis, Retrospective Studies, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods, Survival Analysis, Urinary Bladder Neoplasms pathology, Urinary Bladder Neoplasms surgery, Mutation, Receptor, Fibroblast Growth Factor, Type 3 genetics, Urinary Bladder Neoplasms genetics
Abstract: FGFR3 mutations are common in low-grade urothelial carcinoma and represent a potential therapeutic target in this disease. Their incidence and functional role in high-grade urothelial carcinoma (HGUC), which displays an increased propensity for recurrence and muscularis propria invasion, is less well defined. We developed a mass spectrometry-based genotyping assay to define the incidence of FGFR3 mutations in a large clinically annotated set of urothelial carcinomas. FGFR3 mutations were found in 17% of HGUC versus 84% of low-grade lesions. Retrospective pathological review of the class of FGFR3 mutant HGUC revealed unique histological features, characterized by a bulky, exophytic component with branching papillary architecture as well as irregular nuclei with a koilocytoid appearance. The predictive value of this histological appearance was confirmed using a prospective set of 49 additional HGUCs. Prospective histological review was able to correctly predict for the presence of an FGFR3 mutation in 13/24 HGUC specimens that exhibited the distinct morphology (54%). All 25 specimens lacking the defined histological features were FGFR3 wild-type for a negative predictive value of 100%. Macrodissection of individual tumours confirmed the presence of the FGFR3 mutant allele in non-invasive and invasive, low and high-grade regions of individual tumours and in the lymph node metastases of patients whose tumours possessed the characteristic morphological signature, suggesting that FGFR3 mutations are not restricted to the more clinically indolent regions of HGUCs. These data suggest that histological screening of HGUCs followed by confirmatory genotyping can be used to enrich for the population of HGUCs most likely to harbour activating mutations in the FGFR-3 receptor tyrosine kinase. Histological review could thus aid in the development of targeted inhibitors of FGFR-3 by facilitating the identification of the subset of patients most likely to harbour activating mutations in the FGFR3 gene., (Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.)
Published: 2011
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