265 results on '"Böhringer S"'
Search Results
2. Development of a body dysmorphic disorder screener for DSM-5 (BDDS-5)
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Van Rood, Y.R., Wyk van, N., Böhringer, S., van der Wee, N.J.A., Möllmann, A., and Dingemans, A.E.
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- 2023
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3. OP0033 FIBROBLAST GENE, FKBP7 INDUCED BY Ca2+DEPENDENT ER STRESS ASSOCIATED WITH CLINICAL OUTCOME IN RHEUMATOID ARTHRITIS AND CROHN’S DISEASE; MULTI-CENTRE GWAS AND FUNCTIONAL STUDIES
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Maurits, M. P., primary, Cameron, A., additional, Jelinsky, S., additional, Blüml, S., additional, Abasolo, L., additional, Askling, J., additional, Barton, A., additional, Böhringer, S., additional, Cope, A., additional, De, S., additional, Emery, P., additional, Eyre, S., additional, Gaddi, V. P., additional, González-Álvaro, I., additional, Goodyear, C. S., additional, Hu, X., additional, Huizinga, T., additional, Johannesson, M., additional, Jurado-Zapata, S., additional, Klareskog, L., additional, Lendrem, D., additional, Martin, P., additional, Mc Innes, I. B., additional, Micheroli, R., additional, Morgan, A., additional, Morton, F., additional, Naamane, N., additional, Nagafuchi, Y., additional, Orozco, G., additional, Padyukov, L., additional, Paterson, C., additional, Pitzalis, C., additional, Plant, D., additional, Porter, D., additional, Reynard, L., additional, Rodriguez Rodriguez, L., additional, Sieghart, D., additional, Studenic, P., additional, Taylor, J., additional, Toes, R. E. M., additional, Van den Akker, E. B., additional, Van der Helm – van Mil, A. H. M., additional, Vaskimo, L., additional, Verstappen, S., additional, Westerlind, H., additional, Isaacs, J., additional, Lewis, M., additional, Pratt, A., additional, Ospelt, C., additional, Winkler, A., additional, Thomas, R., additional, and Knevel, R., additional
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- 2024
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4. Identification of pharmacogenetic biomarkers for efficacy of cytoreductive surgery plus hyperthermic intraperitoneal mitomycin C in patients with colorectal peritoneal metastases
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Hulshof, E.C., Lurvink, R.J., Caserta, N., de Hingh, I.H.J.T., van Wezel, T., Böhringer, S., Swen, J.J., Gelderblom, H., Guchelaar, H.J., and Deenen, M.J.
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- 2020
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5. Percentile curves for the knee injury and osteoarthritis outcome score in the middle-aged Dutch population
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Loef, M., Kroon, F.P.B., Böhringer, S., Roos, E.M., Rosendaal, F.R., and Kloppenburg, M.
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- 2020
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6. Religiosität und Spiritualität in der Facharztweiterbildung: Eine Umfrage bei den Weiterbildungsermächtigten für Psychiatrie und Psychotherapie
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Freund, H., Böhringer, S., Utsch, M., and Hauth, I.
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- 2018
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7. OP0016 ABATACEPT TO SILENCE ANTI-CITRULLINATED PROTEIN ANTIBODY-EXPRESSING B CELLS IN RHEUMATOID ARTHRITIS: THE ASCARA TRIAL
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Blomberg, N., primary, Kwekkeboom, J., additional, Böhringer, S., additional, Huizinga, T., additional, Toes, R., additional, and Scherer, H. U., additional
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- 2023
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8. POS0181 THE IMPACT OF AUTOANTIBODIES (RF AND ACPA) ON THE EFFICACY OF BIOLOGICAL DISEASE-MODIFYING ANTIRHEUMATIC DRUGS IN RHEUMATOID ARTHRITIS: META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
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Takase-Minegishi, K., primary, Böhringer, S., additional, Nam, J., additional, Kaneko, Y., additional, Behrens, F., additional, Saevarsdottir, S., additional, Detert, J., additional, Leirisalo-Repo, M., additional, Van der Heijde, D., additional, Landewé, R. B. M., additional, Ramiro, S., additional, and Van der Woude, D., additional
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- 2023
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9. Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.
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Eektimmerman, F., Swen, J.J., Broeder, A.A. den, Hazes, J.M., Kurreeman, F.S., Verstappen, S.M.M., Nair, N., Pawlik, A., Nurmohamed, M.T., Dolžan, V., Böhringer, S., Allaart, C.F., Guchelaar, H.J., Eektimmerman, F., Swen, J.J., Broeder, A.A. den, Hazes, J.M., Kurreeman, F.S., Verstappen, S.M.M., Nair, N., Pawlik, A., Nurmohamed, M.T., Dolžan, V., Böhringer, S., Allaart, C.F., and Guchelaar, H.J.
- Abstract
01 april 2023, Item does not contain fulltext, Hepatotoxicity is a serious adverse drug reaction related to methotrexate (MTX). However, the cause of drug-induced liver injury (DILI) is still unclear and unpredictable. Genetic risk factors may predispose for MTX-DILI. Therefore, we conducted a nested case-control genome-wide association study to explore genetic risk factors associated with MTX-DILI. Seven international groups contributed blood samples and data of patients with rheumatoid arthritis who used MTX. MTX-DILI was defined as an alanine aminotransferase (ALT) level of at least three times the upper limit of normal (ULN), to increase contrast controls ALT levels did not raise above two times the ULN. Per study site, control subjects and patients with MTX-DILI (ratio 3:1) were matched for age, gender, and duration of MTX use. Patients were genotyped using Illumina GSA MD-24v1-0 and data were imputed using the 1000 Genomes reference panel. Single-nucleotide polymorphisms (SNPs) were analyzed using an additive genetic model, corrected for sex, country, and age. A P-value of ≤ 5 × 10(-8) was considered significant, whereas a P-value of ≤ 5 × 10(-6) was considered suggestive. A total of 108 MTX-DILI cases and 311 controls were included for association analysis. None of the SNPs were significantly associated with MTX-DILI. However, we found seven suggestive genetic variants associated with MTX-DILI (P-values 7.43 × 10(-8) to 4.86 × 10(-6) ). Of those, five SNPs were in the intronic protein-coding regions of FTCDNL1, BCOR, FGF14, RBMS3, and PFDN4/DOK5. Investigation of candidates SPATA9 (rs72783407), PLCG2 (rs60427389), RAVER2 (rs72675408), JAK1 (rs72675451), PTPN2 (rs2476601), MTHFR C677T (rs1801133), and into the HLA region did not show significant findings. No genetic variants associated with MTX-DILI were found, whereas suggestive SNPs need further investigation.
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- 2023
10. The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort
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Loef, M., primary, van de Stadt, L., additional, Böhringer, S., additional, Bay-Jensen, A.-C., additional, Mobasheri, A., additional, Larkin, J., additional, Lafeber, F.P.J.G., additional, Blanco, F.J., additional, Haugen, I.K., additional, Berenbaum, F., additional, Giera, M., additional, Ioan-Facsinay, A., additional, and Kloppenburg, M., additional
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- 2022
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11. The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort
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UMC Utrecht Holding, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Loef, M., van de Stadt, L., Böhringer, S., Bay-Jensen, A. C., Mobasheri, A., Larkin, J., Lafeber, F. P.J.G., Blanco, F. J., Haugen, I. K., Berenbaum, F., Giera, M., Ioan-Facsinay, A., Kloppenburg, M., UMC Utrecht Holding, Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Regenerative Medicine and Stem Cells, Loef, M., van de Stadt, L., Böhringer, S., Bay-Jensen, A. C., Mobasheri, A., Larkin, J., Lafeber, F. P.J.G., Blanco, F. J., Haugen, I. K., Berenbaum, F., Giera, M., Ioan-Facsinay, A., and Kloppenburg, M.
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- 2022
12. Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib
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Diekstra, M.H.M., Swen, J.J., Zanden, L.F.M. van der, Vermeulen, S.H., Boven, E., Mathijssen, R.H., Fukunaga, K., Mushiroda, T., Hongo, F., Oosterwijk, E., Cambon-Thomsen, A., Castellano, D., Fritsch, A., Donas, J.G., Rodriguez-Antona, C., Ruijtenbeek, R., Radu, M.T., Eisen, T., Junker, K., Roessler, M., Jaehde, U., Miki, T., Böhringer, S., Kubo, M., Kiemeney, L.A.L.M., Guchelaar, H.J., Diekstra, M.H.M., Swen, J.J., Zanden, L.F.M. van der, Vermeulen, S.H., Boven, E., Mathijssen, R.H., Fukunaga, K., Mushiroda, T., Hongo, F., Oosterwijk, E., Cambon-Thomsen, A., Castellano, D., Fritsch, A., Donas, J.G., Rodriguez-Antona, C., Ruijtenbeek, R., Radu, M.T., Eisen, T., Junker, K., Roessler, M., Jaehde, U., Miki, T., Böhringer, S., Kubo, M., Kiemeney, L.A.L.M., and Guchelaar, H.J.
- Abstract
Contains fulltext : 251723.pdf (Publisher’s version ) (Open Access), Individual response to sunitinib in metastatic renal cell carcinoma (mRCC) patients is highly variable. Earlier, sunitinib outcome was related to single nucleotide polymorphisms (SNPs) in CYP3A5 and ABCB1. Our aim is to provide novel insights into biological mechanisms underlying sunitinib action. We included mRCC patients from the European EuroTARGET consortium (n = 550) and the RIKEN cohort in Japan (n = 204) which were analysed separately and in a meta-analysis of genome-wide association studies (GWAS). SNPs were tested for association with progression-free survival (PFS) and overall survival (OS) using Cox regression. Summary statistics were combined using a fixed effect meta-analysis. SNP rs28520013 in PDLIM3 and the correlated SNPs rs2205096 and rs111356738 both in DSCAM, showed genome-wide significance (p < 5 × 10(-8)) with PFS and OS in the meta-analysis. The variant T-allele of rs28520013 associated with an inferior PFS of 5.1 months compared to 12.5 months in non-carriers (p = 4.02 × 10(-10), HR = 7.26). T-allele carriers of rs28520013 showed an inferior OS of 6.9 months versus 30.2 months in non-carriers (p = 1.62 × 10(-8), HR = 5.96). In this GWAS we identified novel genetic variants in PDLIM3 and DSCAM that impact PFS and OS in mRCC patients receiving sunitinib. The underlying link between the identified genes and the molecular mechanisms of sunitinib action needs to be elucidated.
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- 2022
13. The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort
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Loef, Marieke, van de Stadt, L., Böhringer, S., Bay-Jensen, Anne-C., Mobasheri, Ali, Larkin, Jonathan, Lafeber, Floris P.J.G., Blanco García, Francisco J, Haugen, Ida K., Berenbaum, Francis, Giera, M., Ioan-Facsinay, Andreea, Kloppenburg, Margreet, Loef, Marieke, van de Stadt, L., Böhringer, S., Bay-Jensen, Anne-C., Mobasheri, Ali, Larkin, Jonathan, Lafeber, Floris P.J.G., Blanco García, Francisco J, Haugen, Ida K., Berenbaum, Francis, Giera, M., Ioan-Facsinay, Andreea, and Kloppenburg, Margreet
- Abstract
[Abstract] Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design: We used baseline data from the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) cohort, comprising persons with knee OA fulfilling the clinical American College of Rheumatology classification criteria. Radiographic knee and hand OA severity was quantified with Kellgren-Lawrence sum scores. Knee and hand pain and function were assessed with validated questionnaires. We quantified fasted plasma higher order lipids and oxylipins with liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based platforms. Using penalised linear regression, we assessed the variance in OA severity explained by lipidomics, with adjustment for clinical covariates (age, sex, body mass index (BMI) and lipid lowering medication), measurement batch and clinical centre. Results: In 216 participants (mean age 66 years, mean BMI 27.3 kg/m2, 75% women) we quantified 603 higher order lipids (triacylglycerols, diacylglycerols, cholesteryl esters, ceramides, free fatty acids, sphingomyelins, phospholipids) and 28 oxylipins. Lipidomics explained 3% and 2% of the variance in radiographic knee and hand OA severity, respectively. Lipids were not associated with knee pain or function. Lipidomics accounted for 12% and 6% of variance in hand pain and function, respectively. The investigated OA severity outcomes were associated with the lipidomic fraction of bound and free arachidonic acid, bound palmitoleic acid, oleic acid, linoleic acid and docosapentaenoic acid. Conclusions: Within the APPROACH cohort lipidomics explained a minor portion of the variation in OA severity, which was most evident for the outcome hand pain. Our results suggest that eicosanoids may be involved in OA severity.
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- 2022
14. OP0070 INTERVENTION WITH METHOTREXATE IN ARTHRALGIA AT RISK FOR RHEUMATOID ARTHRITIS TO REDUCE THE DEVELOPMENT OF PERSISTENT ARTHRITIS AND ITS DISEASE BURDEN (TREAT EARLIER): A DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL
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Krijbolder, D., primary, Verstappen, M., additional, van Dijk, B., additional, Dakkak, Y., additional, Burgers, L., additional, Boer, A., additional, Jung Park, Y., additional, De Witt, M., additional, Visser, K., additional, Kok, M. R., additional, Molenaar, E., additional, de Jong, P., additional, Böhringer, S., additional, Huizinga, T., additional, Allaart, C., additional, Niemantsverdriet, E., additional, and van der Helm-van Mil, A., additional
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- 2022
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15. Femmes en Egypte, de l'epoque perse a l'epoque byzantine : Genre et agency
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Boehringer, S, Veisse, A-E, Boehringer, S, and Veisse, A-E
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Issu d'une reflexion partagee entre specialistes de l'Egypte tardive et specialistes des questions de genre antique, ce volume se concentre sur les capacites d'action (agency) des femmes en Egypte, entre le Ve siecle av. J.-C. et le VIIIe siecle ap. J.-C. dans une perspective d'histoire sociale. Plus de 200 noms de femmes emergent de ces travaux, mettant en lumiere la necessite d'une approche mixte des societes antiques. Consulter les oracles, formuler une petition, prendre des decisions, connaitre ses droits, divorcer ou encore tenir des comptes et gerer une entreprise: telles sont les actions, leurs contextes et leurs limites qu'etudient les contributions de ce volume, a partir d'une documentation constituee de papyrus et d'ostraca demotiques, grecs et coptes.
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- 2024
16. POS0123 NEUROPATHIC PAIN SYMPTOMS IN INFLAMMATORY HAND OSTEOARTHRITIS(OA) LOWERS HEALTH RELATED PHYSICAL QUALITY OF LIFE AND MAY REQUIRE ANOTHER APPROACH THAN ANTI-INFLAMMATORY TREATMENT
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Van der Meulen, C., primary, Van de Stadt, L., additional, Kroon, F., additional, Kortekaas, M., additional, Boonen, A., additional, Böhringer, S., additional, Niesters, M., additional, Reijnierse, M., additional, Rosendaal, F., additional, Riyazi, N., additional, Starmans, M., additional, Turkstra, F., additional, Van Zeben, J., additional, Allaart, C., additional, and Kloppenburg, M., additional
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- 2021
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17. Neuropathic pain symptoms in inflammatory hand osteoarthritis (OA) lower quality of life and may require another approach than anti-inflammatory treatment
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van der Meulen, C., primary, van de Stadt, L.A., additional, Kroon, F.P., additional, Kortekaas, M.C., additional, Boonen, A., additional, Böhringer, S., additional, Reijnierse, M., additional, Rosendaal, F.R., additional, Riyazi, N., additional, Starmans, M., additional, Turkstra, F., additional, Van Zeben, J., additional, Allaart, C.F., additional, and Kloppenburg, M., additional
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- 2021
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18. Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease
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Schulte, T., Böhringer, S., Schöls, L., Müller, T., Fischer, C., Riess, O., Przuntek, H., Berger, K., Epplen, J. T., and Krüger, R.
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- 2003
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19. Genetic variants in cell adhesion molecule 1 (CADM1): a validation study of a novel endothelial cell venous thrombosis risk factor: OC 47.2
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De Haan, H G, Bezemer, I D, Van Hylckama Vlieg, A, Vossen, C Y, Böhringer, S, Hasstedt, S J, Levy, S, Rosendaal, F R, and Bovill, E G
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- 2013
20. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis
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Trouw, L. A., Daha, N., Kurreeman, F. A. S., Böhringer, S., Goulielmos, G. N., Westra, H. J., Zhernakova, A., Franke, L., Stahl, E. A., Levarht, E. W. N., Stoeken-Rijsbergen, G., Verduijn, W., Roos, A., Li, Y., Houwing-Duistermaat, J. J., Huizinga, T. W. J., and Toes, R. E. M.
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- 2013
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21. Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations
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Miterski, B, Böhringer, S, Klein, W, Sindern, E, Haupts, M, Schimrigk, S, and Epplen, J T
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- 2002
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22. Genetic variants of C1q are a risk for rheumatoid arthritis
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Jansen, D T S L, Daha, N, Kurreeman, F A S, Böhringer, S, Stoeken-Rijsbergen, G, Houwing-Duistermaat, J J, Huizinga, T W, Toes, R E M, and Trouw, L A
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- 2012
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23. The major risk alleles of age-related macular degeneration (AMD) in CFH do not play a major role in rheumatoid arthritis (RA)
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Trouw, L. A., Böhringer, S., Daha, N. A., Stahl, E. A., Raychaudhuri, S., Kurreeman, F. A., Stoeken-Rijsbergen, G., Houwing-Duistermaat, J. J., Huizinga, T. W., and Toes, R. E.
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- 2011
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24. Genetic variants of C1q are a risk for rheumatoid arthritis: O4
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Daha, N. A., Kurreeman, F. A.S., Böhringer, S., Stoeken-Rijsbergen, G., Houwing-Duistermaat, J. J., Huizinga, T. W., Toes, R. E.M., and Trouw, L. A.
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- 2011
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25. The major risk alleles of age related macular degeneration in CFH, do not play a major role in rheumatoid arthritis
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Shi, J, Böhringer, S, Stahl, E A, Raychaudhuri, S, Kurreeman, F A, Houwing-Duistermaat, J J, Huizinga, T W, Toes, R E, and Trouw, L A
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- 2011
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26. Genetic variants of C1q are a risk for rheumatoid arthritis
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Trouw, L A, Kurreeman, F A S, Daha, N, Böhringer, S, Stoeken-Rijsbergen, G, Houwing-Duistermaat, J J, Huizinga, T W, and Toes, R E
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- 2011
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27. Voice outcome after unilateral ELS type III or bilateral type II resections for T1-T2 glottic carcinoma: Results after 1 year
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Loon, Y. (Yda) van, Hendriksma, Martine, Heijnen, Bas J., Kamp, V.A.H. (Vivienne) van de, Hakkesteegt, M.M. (Marieke), Böhringer, S. (Stefan), Langeveld, T.P.M. (ton), M.A. de Jong MD., PhD, Klop, W.M.C. (Martin), Baatenburg de Jong, R.J. (Robert Jan), Sjögren, E.V. (Elisabeth), Loon, Y. (Yda) van, Hendriksma, Martine, Heijnen, Bas J., Kamp, V.A.H. (Vivienne) van de, Hakkesteegt, M.M. (Marieke), Böhringer, S. (Stefan), Langeveld, T.P.M. (ton), M.A. de Jong MD., PhD, Klop, W.M.C. (Martin), Baatenburg de Jong, R.J. (Robert Jan), and Sjögren, E.V. (Elisabeth)
- Abstract
Background: Voice outcome was assessed in patients with extended T1 and limited T2 glottic carcinoma, treated with a unilateral type III or a bilateral type II resection according to the European Laryngological Society (ELS) classification. Methods: Objective evaluation (acoustic and aerodynamic parameters), perceptual evaluation (GRBAS), and patients' self-assessment (voice handicap index [VHI]) were performed before and 1 year after treatment. Results were evaluated according to ELS resection type and the involvement of the anterior commissure. Results: The majority of voice parameters in all resection subgroups showed an improvement of the mean score 1 year postoperatively. Grade of dysphonia varied between 1.15 and 1.66 postoperatively and VHI score varied from 23.3 to 24.5. Conclusion: Voice outcome after ELS unilateral type III or a bilateral type II resection for extended T1 and limited T2 glottic carcinoma is good with mild to very moderate perceptive dysphonia and low self-reported voice impairment.
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- 2019
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28. Predicting time on the waiting list for HLA matched corneal grafts
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Böhringer, D., Reinhard, T., Böhringer, S., Enczmann, J., Godehard, E., and Sundmacher, R.
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- 2002
29. Three-dimensional soft tissue effects of mandibular midline distraction and surgically assisted rapid maxillary expansion: an automatic stereophotogrammetry landmarking analysis
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Gül, A., primary, de Jong, M.A., additional, de Gijt, J.P., additional, Wolvius, E.B., additional, Kayser, M., additional, Böhringer, S., additional, and Koudstaal, M.J., additional
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- 2019
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30. Ensemble landmarking of 3D facial surface scans
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Jong, M.A. (Markus) de, Hysi, P.G. (Pirro), Spector, T.D. (Timothy), Niessen, W.J. (Wiro), Koudstaal, M.J. (Maarten), Wolvius, E.B. (Eppo), Kayser, M.H. (Manfred), Böhringer, S. (Stefan), Jong, M.A. (Markus) de, Hysi, P.G. (Pirro), Spector, T.D. (Timothy), Niessen, W.J. (Wiro), Koudstaal, M.J. (Maarten), Wolvius, E.B. (Eppo), Kayser, M.H. (Manfred), and Böhringer, S. (Stefan)
- Abstract
Landmarking of 3D facial surface scans is an important analysis step in medical and biological applications, such as genome-wide association studies (GWAS). Manual landmarking is often employed with considerable cost and rater dependent variability. Landmarking automatically with minimal training is therefore desirable. We apply statistical ensemble methods to improve automated landmarking of 3D facial surface scans. Base landmarking algorithms using features derived from 3D surface scans are combined using either bagging or stacking. A focus is on low training complexity of maximal 40 training samples with template based landmarking algorithms that have proved successful in such applications. Additionally, we use correlations between landmark coordinates by introducing a search strategy guided by principal components (PCs) of training landmarks.
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- 2018
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31. New genetic loci link adipose and insulin biology to body fat distribution
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Shungin, D, Winkler, T, Croteau Chonka, D, Ferreira, T, Locke, A, Mägi, R, Strawbridge, R, Pers, T, Fischer, K, Justice, A, Workalemahu, T, Wu, J, Buchkovich, M, Heard Costa, N, Roman, T, Drong, A, Song, C, Gustafsson, S, Day, F, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J, Scherag, A, Vedantam, S, Wood, A, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg Gresham, J, Buyske, S, Demirkan, A, Ehret, G, Feitosa, M, Goel, A, Jackson, A, Johnson, T, Kleber, M, Kristiansson, K, Mangino, M, Leach, I, Medina Gomez, C, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Stanca'Kova', A, Sung, Y, Tanaka, T, Teumer, A, Van Vliet Ostaptchouk, J, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, G, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, D, Caspersen, I, Clarke, R, Daw, E, Deelen, J, Deelman, E, Delgado, G, Doney, A, 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- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
32. THE IMPACT OF AUTOANTIBODIES (RF AND ACPA) ON THE EFFICACY OF BIOLOGICAL DISEASE-MODIFYING ANTIRHEUMATIC DRUGS IN RHEUMATOID ARTHRITIS: META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.
- Author
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Takase-Minegishi, K., Böhringer, S., Nam, J., Kaneko, Y., Behrens, F., Saevarsdottir, S., Detert, J., Leirisalo-Repo, M., Van der Heijde, D., Landewé, R. B. M., Ramiro, S., and Van der Woude, D.
- Published
- 2023
- Full Text
- View/download PDF
33. Novel quantitative pigmentation phenotyping enhances genetic association, epistasis, and prediction of human eye colour
- Author
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Wollstein, A. (Andreas), Walsh, S. (Susan), Liu, F. (Fan), Chakravarthy, U. (Usha), Rahu, M., Seland, J.H. (Johan ), Soubrane, G., Tomazzoli, L. (Laura), Topouzis, F. (Fotis), Vingerling, J.R. (Hans), Vioque, J. (Jesus), Böhringer, S. (Stefan), Fletcher, A.E. (Astrid E.), Kayser, M.H. (Manfred), Wollstein, A. (Andreas), Walsh, S. (Susan), Liu, F. (Fan), Chakravarthy, U. (Usha), Rahu, M., Seland, J.H. (Johan ), Soubrane, G., Tomazzoli, L. (Laura), Topouzis, F. (Fotis), Vingerling, J.R. (Hans), Vioque, J. (Jesus), Böhringer, S. (Stefan), Fletcher, A.E. (Astrid E.), and Kayser, M.H. (Manfred)
- Abstract
Success of genetic association and the prediction of phenotypic traits from DNA are known to depend on the accuracy of phenotype characterization, amongst other parameters. To overcome limitations in the characterization of human iris pigmentation, we introduce a fully automated approach that specifies the areal proportions proposed to represent differing pigmentation types, such as pheomelanin, eumelanin, and non-pigmented areas within the iris. We demonstrate the utility of this approach using high-resolution digital eye imagery and genotype data from 12 selected SNPs from over 3000 European samples of seven populations that are part of the EUREYE study. In comparison to previous quantification approaches, (1) we achieved an overall improvement in eye colour phenotyping, which provides a better separation of manually defined eye colour categories. (2) Single nucleotide polymorphisms (SNPs) known to be involved in human eye colour variation showed stronger associations with our approach. (3) We found new and confirmed previously noted SNP-SNP interactions. (4) We increased SNP-based prediction accuracy of quantitative eye colour. Our findings exemplify that precise quantification using the perceived biological basis of pigmentation leads to enhanced genetic association and prediction of eye colour. We expect our approach to deliver new pigmentation genes when applied to genome-wide association testing.
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- 2017
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34. Detection of localized overload during the bedding of patient as an alarm system for decubitus prophylaxes
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Böhringer, S., Suter, Ch, Jeker, M., Hradetzky, D., Böhringer, S., Suter, Ch, Jeker, M., and Hradetzky, D.
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- 2017
35. Optimization of a Miniaturized Electrospray Device by Combining High Speed Video Imaging and Fem Modelling
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Böhringer, S., Kalle, C., Hradetzky, D., Böhringer, S., Kalle, C., and Hradetzky, D.
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- 2017
36. Decubitus prophylaxes in surgery: A novel approach using active load controlled bedding system
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Hradetzky, D., Messerli, D., Harsch, S., Jeker, M., Böhringer, S., Schkommodau, E., Hradetzky, D., Messerli, D., Harsch, S., Jeker, M., Böhringer, S., and Schkommodau, E.
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- 2017
37. Religiosität und Spiritualität in der Facharztweiterbildung
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Freund, H., primary, Böhringer, S., additional, Utsch, M., additional, and Hauth, I., additional
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- 2017
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38. A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function
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McCarthy, M.I., Porcu, E., Medici, M., Pistis, G., Volpato, C.B., Wilson, S.G., Cappola, A.R., Bos, S.D., Deelen, J., den Heijer, M., Freathy, R.M., Lahti, J., Liu, C., Lopez, L.M., Nolte, I.M., O'Connell, J.R., Tanaka, T., Trompet, S., Arnold, A., Bandinelli, S., Beekman, M., Böhringer, S., Brown, S.J., Buckley, B.M., Camaschella, C., de Craen, A.J.M., Davies, G., de Visser, M.C.H., Ford, I., Forsen, T., Frayling, T.M., Fugazzola, L., Gögele, M., Hattersley, A.T., Hermus, A.R., Hofman, A., Houwing-Duistermaat, J.J., Jensen, R.A., Kajantie, E., Kloppenburg, M., Lim, E.M., Masciullo, C., Mariotti, S., Minelli, C., Mitchell, B.D., Nagaraja, R., Netea-Maier, R.T., Palotie, A., Persani, L., Piras, M.G., Psaty, B.M., Räikkönen, K., Richards, J.B., Rivadeneira, F., Sala, C., Sabra, M.M., Sattar, N., Shields, B.M., Soranzo, N., Starr, J.M., Stott, D.J., Sweep, F.C.G.J., Usala, G., van der Klauw, M.M., van Heemst, D., van Mullem, A., H.Vermeulen, S., Visser, W.E., Walsh, J.P., Westendorp, R.G.J., Widen, E., Zhai, G., Cucca, F., Deary, I.J., Eriksson, J.G., Ferrucci, L., Fox, C.S., Jukema, J.W., Kiemeney, L.A., Pramstaller, P.P., Schlessinger, D., Shuldiner, A.R., Slagboom, E.P., Uitterlinden, A.G., Vaidya, B., Visser, T.J., Wolffenbuttel, B.H.R., Meulenbelt, I., Rotter, J.I., Spector, T.D., Hicks, A.A., Toniolo, D., Sanna, S., Peeters, R.P., Naitza, S., Internal Medicine, Clinical Genetics, Public Health, Epidemiology, Internal medicine, ICaR - Circulation and metabolism, Behavioural Sciences, Clinicum, Department of General Practice and Primary Health Care, Children's Hospital, Lastentautien yksikkö, Institute for Molecular Medicine Finland, Haartman Institute (-2014), Department of Medical and Clinical Genetics, Diabetes and Obesity Research Program, Developmental Psychology Research Group, Genomics of Neurological and Neuropsychiatric Disorders, Genomic Discoveries and Clinical Translation, Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Porcu, E, Medici, M, Pistis, G, Volpato, Cb, Wilson, Sg, Cappola, Ar, Bos, Sd, Deelen, J, DEN HEIJER, M, Freathy, Rm, Lahti, J, Liu, C, Lopez, Lm, Nolte, Im, O'Connell, Jr, Tanaka, T, Trompet, S, Arnold, A, Bandinelli, S, Beekman, M, Böhringer, S, Brown, Sj, Buckley, Bm, Camaschella, Clara, DE CRAEN, Aj, Davies, G, DE VISSER, Mc, Ford, I, Forsen, T, Frayling, Tm, Fugazzola, L, Gögele, M, Hattersley, At, Hermus, Ar, Hofman, A, HOUWING DUISTERMAAT, Jj, Jensen, Ra, Kajantie, E, Kloppenburg, M, Lim, Em, Masciullo, C, Mariotti, S, Minelli, C, Mitchell, Bd, Nagaraja, R, NETEA MAIER, Rt, Palotie, A, Persani, L, Piras, Mg, Psaty, Bm, Räikkönen, K, Richards, Jb, Rivadeneira, F, Sala, C, Sabra, Mm, Sattar, N, Shields, Bm, Soranzo, N, Starr, Jm, Stott, Dj, Sweep, Fc, Usala, G, VAN DER KLAUW, Mm, VAN HEEMST, D, VAN MULLEM, A, Vermeulen, Sh, Visser, We, Walsh, Jp, Westendorp, Rg, Widen, E, Zhai, G, Cucca, F, Deary, Ij, Eriksson, Jg, Ferrucci, L, Fox, C, Jukema, Jw, Kiemeney, La, Pramstaller, Pp, Schlessinger, D, Shuldiner, Ar, Slagboom, Ep, Uitterlinden, Ag, Vaidya, B, Visser, Tj, Wolffenbuttel, Bh, Meulenbelt, I, Rotter, Ji, Spector, Td, Hicks, Aa, Toniolo, D, Sanna, S, Peeters, Rp, and Naitza, S.
- Subjects
Male ,Cancer Research ,endocrine system diseases ,Factor binding protein 5 ,Thyroid Gland ,FACTOR BINDING PROTEIN-5 ,Thyrotropin ,Genome-wide association study ,Expression ,Aetiology, screening and detection [ONCOL 5] ,Growth ,Hyperthyroidism ,CLEFT-PALATE ,Serum TSH ,0302 clinical medicine ,Euthyroid ,Genetics (clinical) ,0303 health sciences ,Sex Characteristics ,factor binding protein-S ,Thyroid ,3. Good health ,medicine.anatomical_structure ,Phenotype ,NFIA ,Cleft palate ,GROWTH ,Genome wide Association ,Female ,Thyroid function ,hormones, hormone substitutes, and hormone antagonists ,Research Article ,Signal Transduction ,EXPRESSION ,medicine.medical_specialty ,endocrine system ,lcsh:QH426-470 ,cleft-palate ,515 Psychology ,education ,030209 endocrinology & metabolism ,Biology ,Polymorphism, Single Nucleotide ,Molecular epidemiology [NCEBP 1] ,03 medical and health sciences ,Thyroid-stimulating hormone ,Hypothyroidism ,SERUM TSH ,Internal medicine ,medicine ,Genetics ,Humans ,Hormonal regulation Translational research [IGMD 6] ,GENOME-WIDE ASSOCIATION ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Health aging / healthy living Cardiovascular diseases [IGMD 5] ,030304 developmental biology ,Molecular epidemiology Aetiology, screening and detection [NCEBP 1] ,Polymorphism, Genetic ,THYROTROPIN ,HORMONE PATHWAY GENES ,Hormonal regulation [IGMD 6] ,R1 ,Thyroxine ,Common variation ,lcsh:Genetics ,Endocrinology ,HYPOTHYROIDISM ,Hormone pathway genes ,genome-wide association ,Hormonal regulation Aetiology, screening and detection [IGMD 6] ,3111 Biomedicine ,COMMON VARIATION ,Hormone ,FOXE1 ,Genome-Wide Association Study ,Developmental Biology - Abstract
Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4, in up to 26,420 and 17,520 euthyroid subjects, respectively. Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1, SASH1, GLIS3) and FT4 (LHX3, FOXE1, AADAT, NETO1/FBXO15, LPCAT2/CAPNS2). Notably, only limited overlap was detected between TSH and FT4 associated signals, in spite of the feedback regulation of their circulating levels by the hypothalamic-pituitary-thyroid axis. Five of the reported loci (PDE8B, PDE10A, MAF/LOC440389, NETO1/FBXO15, and LPCAT2/CAPNS2) show strong gender-specific differences, which offer clues for the known sexual dimorphism in thyroid function and related pathologies. Importantly, the TSH-associated loci contribute not only to variation within the normal range, but also to TSH values outside the reference range, suggesting that they may be involved in thyroid dysfunction. Overall, our findings explain, respectively, 5.64% and 2.30% of total TSH and FT4 trait variance, and they improve the current knowledge of the regulation of hypothalamic-pituitary-thyroid axis function and the consequences of genetic variation for hypo- or hyperthyroidism., Author Summary Levels of thyroid hormones are tightly regulated by TSH produced in the pituitary, and even mild alterations in their concentrations are strong indicators of thyroid pathologies, which are very common worldwide. To identify common genetic variants associated with the highly heritable markers of thyroid function, TSH and FT4, we conducted a meta-analysis of genome-wide association studies in 26,420 and 17,520 individuals, respectively, of European ancestry with normal thyroid function. Our analysis identified 26 independent genetic variants regulating these traits, several of which are new, and confirmed previously detected polymorphisms affecting TSH (within the PDE8B gene and near CAPZB, MAF/LOC440389, and NR3C2) and FT4 (within DIO1) levels. Gender-specific differences in the genetic effects of several variants for TSH and FT4 levels were identified at several loci, which offer clues to understand the known sexual dimorphism in thyroid function and pathology. Of particular clinical interest, we show that TSH-associated loci contribute not only to normal variation, but also to TSH values outside reference range, suggesting that they may be involved in thyroid dysfunction. Overall, our findings add to the developing landscape of the regulation of thyroid homeostasis and the consequences of genetic variation for thyroid related diseases.
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- 2013
39. Zeiterfassung in ophthalmologischen klinischen Studien. Eine multizentrische Feldstudie.
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Böhringer, D., Goos, D., Ach, T., Feltgen, N., Fleckenstein, M., Kohnen, T., Lorenz, K., Pielen, A., Spital, G., Wilhelm, B., Böhringer, S., and Reinhard, T.
- Abstract
Copyright of Der Ophthalmologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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40. Microarray gene expression analysis to evaluate cell type specific expression of targets relevant for immunotherapy of hematological malignancies
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Pont, MJ, Honders, MW, Kremer, AN, Van Kooten, C, Out, C, Hiemstra, PS, De Boer, HC, Jager, MJ, Schmelzer, E, Vries, RG, Al Hinai, AS, Kroes, WG, Monajemi, R, Goeman, JJ, Böhringer, S, Marijt, WAF, Falkenburg, JHF, Griffioen, M, Pont, MJ, Honders, MW, Kremer, AN, Van Kooten, C, Out, C, Hiemstra, PS, De Boer, HC, Jager, MJ, Schmelzer, E, Vries, RG, Al Hinai, AS, Kroes, WG, Monajemi, R, Goeman, JJ, Böhringer, S, Marijt, WAF, Falkenburg, JHF, and Griffioen, M
- Abstract
Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation and more recently by targeted therapy with chimeric antigen or T-cell receptor-engineered T cells. However, dependent on the tissue distribution of the antigens that are targeted, anti-tumor responses can be accompanied by undesired side effects. Therefore, detailed tissue distribution analysis is essential to estimate potential efficacy and toxicity of candidate targets for immunotherapy of hematological malignancies. We performed microarray gene expression analysis of hematological malignancies of different origins, healthy hematopoietic cells and various non-hematopoietic cell types from organs that are often targeted in detrimental immune responses after allogeneic stem cell transplantation leading to graft-versus-host disease. Non-hematopoietic cells were also cultured in the presence of IFN-γ to analyze gene expression under inflammatory circumstances. Gene expression was investigated by Illumina HT12.0 microarrays and quality control analysis was performed to confirm the cell-type origin and exclude contamination of non-hematopoietic cell samples with peripheral blood cells. Microarray data were validated by quantitative RT-PCR showing strong correlations between both platforms. Detailed gene expression profiles were generated for various minor histocompatibility antigens and B-cell surface antigens to illustrate the value of the microarray dataset to estimate efficacy and toxicity of candidate targets for immunotherapy. In conclusion, our microarray database provides a relevant platform to analyze and select candidate antigens with hematopoietic (lineage)-restricted expression as potential targets for immunotherapy of hematological cancers.
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- 2016
41. Microarray gene expression analysis to evaluate cell type specific expression of targets relevant for immunotherapy of hematological malignancies
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Pont, M. J., Honders, M. W., Kremer, A. N., Van Kooten, C., Out, C., Hiemstra, P. S., De Boer, H. C., Jager, M. J., Schmelzer, E., Vries, R. G., Al Hinai, A. S., Kroes, W. G., Monajemi, R., Goeman, J. J., Böhringer, S., Marijt, W. A F, Falkenburg, J. H F, Griffioen, M., Pont, M. J., Honders, M. W., Kremer, A. N., Van Kooten, C., Out, C., Hiemstra, P. S., De Boer, H. C., Jager, M. J., Schmelzer, E., Vries, R. G., Al Hinai, A. S., Kroes, W. G., Monajemi, R., Goeman, J. J., Böhringer, S., Marijt, W. A F, Falkenburg, J. H F, and Griffioen, M.
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- 2016
42. Microarray gene expression analysis to evaluate cell type specific expression of targets relevant for immunotherapy of hematological malignancies
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Hubrecht Institute with UMC, Pont, M. J., Honders, M. W., Kremer, A. N., Van Kooten, C., Out, C., Hiemstra, P. S., De Boer, H. C., Jager, M. J., Schmelzer, E., Vries, R. G., Al Hinai, A. S., Kroes, W. G., Monajemi, R., Goeman, J. J., Böhringer, S., Marijt, W. A F, Falkenburg, J. H F, Griffioen, M., Hubrecht Institute with UMC, Pont, M. J., Honders, M. W., Kremer, A. N., Van Kooten, C., Out, C., Hiemstra, P. S., De Boer, H. C., Jager, M. J., Schmelzer, E., Vries, R. G., Al Hinai, A. S., Kroes, W. G., Monajemi, R., Goeman, J. J., Böhringer, S., Marijt, W. A F, Falkenburg, J. H F, and Griffioen, M.
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- 2016
43. Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies
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Pont, M. J., primary, Honders, M. W., additional, Kremer, A. N., additional, van Kooten, C., additional, Out, C., additional, Hiemstra, P. S., additional, de Boer, H. C., additional, Jager, M. J., additional, Schmelzer, E., additional, Vries, R. G., additional, Al Hinai, A. S., additional, Kroes, W. G., additional, Monajemi, R., additional, Goeman, J. J., additional, Böhringer, S., additional, Marijt, W. A. F., additional, Falkenburg, J. H. F., additional, and Griffioen, M., additional
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- 2016
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44. New genetic loci link adipose and insulin biology to body fat distribution.
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ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, GLGC, ICBP, Dastani, Z., Hivert, MF., Timpson, N., Perry, JR., Yuan, X., Scott, RA., Henneman, P., Heid, IM., Kizer, JR., Lyytikainen, LP., Fuchsberger, C., Tanaka, T., Morris, AP., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., Pankow, JS., Uh, HW., Wu, Y., Bidulescu, A., Rasmussen-Torvik, LJ., Greenwood, CM., Ladouceur, M., Grimsby, J., Manning, AK., Liu, CT., Kooner, J., Mooser, VE., Vollenweider, P., Kapur, KA., Chambers, J., Wareham, NJ., Langenberg, C., Frants, R., Willemsvan-vanDijk, K., Oostra, BA., Willems, SM., Lamina, C., Winkler, T., Psaty, BM., Tracy, RP., Brody, J., Chen, I., Viikari, J., Kähönen, M., Pramstaller, PP., Evans, DM., St Pourcain, B., Sattar, N., Wood, A., Bandinelli, S., Carlson, OD., Egan, JM., Böhringer, S., van Heemst, D., Kedenko, L., Kristiansson, K., Nuotio, ML., Loo, BM., Harris, T., Garcia, M., Kanaya, A., Haun, M., Klopp, N., Wichmann, HE., Deloukas, P., Katsareli, E., Couper, DJ., Duncan, BB., Kloppenburg, M., Adair, LS., Borja, JB., Wilson, JG., Musani, S., Guo, X., Johnson, T., Semple, R., Teslovich, TM., Allison, MA., Redline, S., Buxbaum, SG., Mohlke, KL., Meulenbelt, I., Ballantyne, CM., Dedoussis, GV., Hu, FB., Liu, Y., Paulweber, B., Spector, TD., Slagboom, P., Ferrucci, L., Jula, A., Perola, M., Raitakari, O., Florez, JC., Salomaa, V., Eriksson, JG., Frayling, TM., Hicks, AA., Lehtimäki, T., Smith, GD., Siscovick, DS., Kronenberg, F., van Duijn, C., Loos, RJ., Waterworth, DM., Meigs, JB., Dupuis, J., Richards, JB., Willenborg, C., Farrall, M., Assimes, TL., Thompson, JR., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, BA., Stirrups, K., König, IR., Cazier, JB., Johansson£££Åsa£££ Å., Hall, AS., Lee, JY., Willer, CJ., Chambers, JC., Esko£££Tõnu£££ T., Folkersen, L., Goel, A., Grundberg, E., Havulinna, AS., Ho, WK., Hopewell, JC., Eriksson, N., Kleber, ME., Lundmark, P., Lyytikäinen, LP., Rafelt, S., Shungin, D., Strawbridge, RJ., Thorleifsson, G., Tikkanen, E., Van Zuydam, N., Voight, BF., Waite, LL., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, AJ., Barroso£££Inês£££ I., Braund, PS., Burgdorf, C., Claudi-Boehm, S., Cox, D., Dimitriou, M., Do, R., Doney, AS., El Mokhtari, N., Eriksson, P., Fischer, K., Fontanillas, P., Franco-Cereceda, A., Gigante, B., Groop, L., Gustafsson, S., Hager, J., Hallmans, G., Han, BG., Hunt, SE., Kang, HM., Illig, T., Kessler, T., Knowles, JW., Kolovou, G., Kuusisto, J., Langford, C., Leander, K., Lokki, ML., Lundmark, A., McCarthy, MI., Meisinger, C., Melander, O., Mihailov, E., Maouche, S., Morris, AD., Müller-Nurasyid, M., Nikus, K., Peden, JF., Rayner, NW., Rasheed, A., Rosinger, S., Rubin, D., Rumpf, MP., Schäfer, A., Sivananthan, M., Song, C., Stewart, AF., Tan, ST., Thorgeirsson, G., van der Schoot CE., Wagner, PJ., Wells, GA., Wild, PS., Yang, TP., Amouyel, P., Arveiler, D., Basart, H., Boehnke, M., Boerwinkle, E., Brambilla, P., Cambien, F., Cupples, AL., de Faire, U., Dehghan, A., Diemert, P., Epstein, SE., Evans, A., Ferrario, MM., Ferrières, J., Gauguier, D., Go, AS., Goodall, AH., Gudnason, V., Hazen, S., Holm, H., Iribarren, C., Jang, Y., Kee, F., Kim, HS., Koenig, W., Kratzer, W., Kuulasmaa, K., Laakso, M., Laaksonen, R., Lind, L., Ouwehand, WH., Parish, S., Park, JE., Pedersen, NL., Peters, A., Quertermous, T., Rader, DJ., Schadt, E., Shah, SH., Sinisalo, J., Stark, K., Stefansson, K., Trégouët, DA., Virtamo, J., Wallentin, L., Wareham, N., Zimmermann, ME., Nieminen, MS., Hengstenberg, C., Sandhu, MS., Pastinen, T., Syvänen, AC., Hovingh, GK., Dedoussis, G., Franks, PW., Metspalu, A., Zalloua, PA., Siegbahn, A., Schreiber, S., Ripatti, S., Blankenberg, SS., Clarke, R., Boehm, BO., O'Donnell, C., Reilly, MP., März, W., Collins, R., Kathiresan, S., Hamsten, A., Kooner, JS., Thorsteinsdottir, U., Danesh, J., Palmer, CN., Roberts, R., Watkins, H., Schunkert, H., Samani, NJ., Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, CA., Olden, M., Chen, MH., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, MC., O'Seaghdha, CM., Glazer, N., Smith, AV., O'Connell, JR., Struchalin, M., Li, G., Johnson, AD., Gierman, HJ., Feitosa, M., Hwang, SJ., Atkinson, EJ., Cornelis, MC., Tönjes, A., Chouraki, V., Holliday, EG., Sorice, R., Kutalik, Z., Deshmukh, H., Ulivi, S., Chu, AY., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Harris, TB., Launer, LJ., Aspelund, T., Eiriksdottir, G., Mitchell, BD., Schmidt, H., Cavalieri, M., Rao, M., Demirkan, A., de Andrade, M., Turner, ST., Ding, J., Andrews, JS., Freedman, BI., Döring, A., Wichmann, H-., Kolcic, I., Zemunik, T., Boban, M., Minelli, C., Wheeler, HE., Igl, W., Zaboli, G., Wild, SH., Wright, AF., Campbell, H., Ellinghaus, 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- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
45. New genetic loci link adipose and insulin biology to body fat distribution
- Author
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Shungin, D. (Dmitry), Winkler, T.W. (Thomas W.), Croteau-Chonka, D.C. (Damien), Ferreira, T. (Teresa), Locke, A. (Adam), Mägi, R. (Reedik), Strawbridge, R.J. (Rona), Pers, T.H. (Tune), Fischer, K. (Krista), Justice, A.E. (Anne), Workalemahu, T. (Tsegaselassie), Wu, J.M.W. (Joseph M. W.), Buchkovich, M.L. (Martin), Heard-Costa, N.L. (Nancy), Roman, T.S. (Tamara S.), Drong, A. (Alexander), Song, C. (Ci), Gustafsson, S. (Stefan), Day, F.R. (Felix), Esko, T. (Tõnu), Fall, M. (Magnus), Kutalik, Z. (Zolta'n), Luan, J., Randall, J.C. (Joshua), Scherag, A. (Andre), Vedantam, S. (Sailaja), Wood, A.R. (Andrew), Chen, J. (Jin), Fehrmann, R.S.N. (Rudolf), Karjalainen, J. (Juha), Kahali, B. (Bratati), Liu, C.-T. (Ching-Ti), Schmidt, E.M. (Ellen), Absher, D. (Devin), Amin, N. (Najaf), Beekman, M. (Marian), Bragg-Gresham, J.L. (Jennifer L.), Buyske, S. (Steven), Demirkan, A. (Ayşe), Ehret, G.B. (Georg), Feitosa, M.F. (Mary Furlan), Goel, A. (Anuj), Jackson, A.U. (Anne), Johnson, T. (Toby), Kleber, M.E. (Marcus), Kristiansson, K. (Kati), Mangino, M. (Massimo), Leach, I.M. (Irene Mateo), Medina-Gomez, M.C. (Carolina), Palmer, C. (Cameron), Pasko, D. (Dorota), Pechlivanis, S. (Sonali), Peters, M.J. (Marjolein), Prokopenko, I. (Inga), Stanca'kova', A. (Alena), Sung, Y.J. (Yun Ju), Tanaka, T. (Toshiko), Teumer, A. (Alexander), Vliet-Ostaptchouk, J.V. (Jana) van, Yengo, L. (Loic), Zhang, W. (Weihua), Albrecht, E. (Eva), Ärnlöv, J. (Johan), Arscott, G.M. (Gillian M.), Bandinelli, S. (Stefania), Barrett, A. (Angela), Bellis, C. (Claire), Bennett, A.J. (Amanda), Berne, C. (Christian), Blüher, M. (Matthias), Böhringer, S. (Stefan), Bonnet, F. (Fabrice), Böttcher, Y. (Yvonne), Bruinenberg, M. (M.), Carba, D.B. (Delia B.), Caspersen, I.H. (Ida H.), Clarke, R. (Robert), Daw, E.W. (E. Warwick), Deelen, J. (Joris), Deelman, E. (Ewa), Delgado, G., Doney, A.S.F. (Alex), Eklund, N. (Niina), Erdos, M.R. (Michael), Estrada Gil, K. (Karol), Eury, E. (Elodie), Friedrich, N. 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(Colin), Pedersen, N.L. (Nancy L.), Perola, M. (Markus), Perusse, L. (Louis), Peters, U. (Ulrike), Power, C. (Christopher), Quertermous, T. (Thomas), Rauramaa, R. (Rainer), Rivadeneira Ramirez, F. (Fernando), Saaristo, T. (Timo), Saleheen, D., Sinisalo, J. (Juha), Slagboom, P.E. (Eline), Snieder, H. (Harold), Spector, T.D. (Timothy), Thorsteinsdottir, U. (Unnur), Stumvoll, M. (Michael), Tuomilehto, J. (Jaakko), Uitterlinden, A.G. (André), Uusitupa, M. (Matti), Harst, P. (Pim) van der, Veronesi, G. (Giovanni), Walker, M. (Mark), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wichmann, H.E. (Heinz Erich), Abecasis, G.R. (Gonçalo), Assimes, T.L. (Themistocles), Berndt, S.I. (Sonja), Boehnke, M. (Michael), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Franke, L. (Lude), Frayling, T.M. (Timothy), Groop, L. (Leif), Hunter, D. (David), Kaplan, R.C. (Robert), O´Connell, J.R., Qi, L. (Lu), Schlessinger, D. (David), Strachan, D.P. (David), Zwart, J-A. (John-Anker), Duijn, C.M. (Cornelia) van, Willer, C.J. (Cristen), Visscher, P.M. (Peter), Yang, J. (Joanna), Hirschhorn, J.N. (Joel N.), Zillikens, M.C. (Carola), McCarthy, M.I. (Mark), Speliotes, E.K. (Elizabeth), North, K.E. (Kari), Fox, C.S. (Caroline S.), Barroso, I.E. (Inês), Franks, P.W. (Paul), Anderson, D. (Denise), Ingelsson, E. (Erik), Heid, I.M. (Iris), Loos, R.J.F. (Ruth), Cupples, L.A. (Adrienne), Morris, A.P. (Andrew), Lindgren, C.M. (Cecilia), Mohlke, K.L. (Karen), Shungin, D. (Dmitry), Winkler, T.W. (Thomas W.), Croteau-Chonka, D.C. (Damien), Ferreira, T. (Teresa), Locke, A. (Adam), Mägi, R. (Reedik), Strawbridge, R.J. (Rona), Pers, T.H. (Tune), Fischer, K. (Krista), Justice, A.E. (Anne), Workalemahu, T. (Tsegaselassie), Wu, J.M.W. (Joseph M. W.), Buchkovich, M.L. (Martin), Heard-Costa, N.L. (Nancy), Roman, T.S. (Tamara S.), Drong, A. (Alexander), Song, C. (Ci), Gustafsson, S. (Stefan), Day, F.R. (Felix), Esko, T. (Tõnu), Fall, M. (Magnus), Kutalik, Z. (Zolta'n), Luan, J., Randall, J.C. (Joshua), Scherag, A. (Andre), Vedantam, S. (Sailaja), Wood, A.R. (Andrew), Chen, J. (Jin), Fehrmann, R.S.N. (Rudolf), Karjalainen, J. (Juha), Kahali, B. (Bratati), Liu, C.-T. (Ching-Ti), Schmidt, E.M. (Ellen), Absher, D. (Devin), Amin, N. (Najaf), Beekman, M. (Marian), Bragg-Gresham, J.L. (Jennifer L.), Buyske, S. (Steven), Demirkan, A. (Ayşe), Ehret, G.B. (Georg), Feitosa, M.F. (Mary Furlan), Goel, A. (Anuj), Jackson, A.U. (Anne), Johnson, T. (Toby), Kleber, M.E. (Marcus), Kristiansson, K. (Kati), Mangino, M. (Massimo), Leach, I.M. (Irene Mateo), Medina-Gomez, M.C. (Carolina), Palmer, C. (Cameron), Pasko, D. (Dorota), Pechlivanis, S. (Sonali), Peters, M.J. (Marjolein), Prokopenko, I. (Inga), Stanca'kova', A. (Alena), Sung, Y.J. (Yun Ju), Tanaka, T. (Toshiko), Teumer, A. (Alexander), Vliet-Ostaptchouk, J.V. (Jana) van, Yengo, L. (Loic), Zhang, W. (Weihua), Albrecht, E. (Eva), Ärnlöv, J. (Johan), Arscott, G.M. (Gillian M.), Bandinelli, S. (Stefania), Barrett, A. (Angela), Bellis, C. (Claire), Bennett, A.J. (Amanda), Berne, C. (Christian), Blüher, M. (Matthias), Böhringer, S. (Stefan), Bonnet, F. (Fabrice), Böttcher, Y. (Yvonne), Bruinenberg, M. (M.), Carba, D.B. (Delia B.), Caspersen, I.H. (Ida H.), Clarke, R. (Robert), Daw, E.W. (E. Warwick), Deelen, J. (Joris), Deelman, E. (Ewa), Delgado, G., Doney, A.S.F. (Alex), Eklund, N. (Niina), Erdos, M.R. (Michael), Estrada Gil, K. (Karol), Eury, E. (Elodie), Friedrich, N. (Nele), Garcia, M. (Melissa), Giedraitis, V. (Vilmantas), Gigante, B. (Bruna), Go, A.T.J.I. (Attie), Golay, A. (Alain), Grallert, H. (Harald), Grammer, T.B. (Tanja), Gräsler, J. (Jürgen), Grewal, J. (Jagvir), Groves, C.J. (Christopher), Haller, T. (Toomas), Hallmans, G. (Göran), Hartman, C.A. (Catharina), Hassinen, M. (Maija), Hayward, C. (Caroline), Heikkilä, K. (Kauko), Herzig, K.H., Helmer, Q. (Quinta), Hillege, H.L. (Hans), Holmen, O.L. (Oddgeir), Hunt, S.C. (Steven), Isaacs, A. (Aaron), Ittermann, T. (Till), James, A.L. (Alan), Johansson, I. (Inger), Juliusdottir, T. (Thorhildur), Kalafati, I.-P. (Ioanna-Panagiota), Kinnunen, L. (Leena), Koenig, W. (Wolfgang), Kooner, I.K. (Ishminder K.), Kratzer, W. (Wolfgang), Lamina, C. (Claudia), Leander, K. (Karin), Lee, N.R. (Nanette R.), Lichtner, P. (Peter), Lind, L. (Lars), Lindström, J. (Jaana), Lobbens, S. (Stéphane), Lorentzon, M. (Mattias), MacH, F. (François), Magnusson, P.K. (Patrik), Mahajan, A. (Anubha), McArdle, W.L. (Wendy), Menni, C. (Cristina), Merger, S. (Sigrun), Mihailov, E. (Evelin), Milani, L. (Lili), Mills, R. (Rebecca), Moayyeri, A. (Alireza), Monda, K.L. (Keri), Mooijaart, S.P. (Simon), Mühleisen, T.W. (Thomas), Mulas, A. (Antonella), Müller, G. (Gabriele), Müller-Nurasyid, M. (Martina), Nagaraja, R. (Ramaiah), Nalls, M.A. (Michael), Narisu, N. (Narisu), Glorioso, N. (Nicola), Nolte, I.M. (Ilja M.), Olden, M. (Matthias), Rayner, N.W. (Nigel William), Renström, F. (Frida), Ried, J.S. (Janina), Robertson, N.R. (Neil R.), Rose, L.M. (Lynda), Sanna, S. (Serena), Scharnagl, H. (Hubert), Scholtens, S. (Salome), Sennblad, B. (Bengt), Seufferlein, T. (Thomas), Sitlani, C.M. (Colleen), Smith, A.V. (Davey), Stirrups, K. (Kathy), Stringham, H.M. (Heather), Sundstrom, J. (Johan), Swertz, M. (Morris), Swift, A.J. (Amy), Syvanen, A.C., Tayo, B. (Bamidele), Thorand, B. (Barbara), Thorleifsson, G. (Gudmar), Tomaschitz, A. (Andreas), Troffa, C. (Chiara), Oort, F.V.A. (Floor) van, Verweij, N. (Niek), Vonk, J.M. (Judith), Waite, L. (Lindsay), Wennauer, R. (Roman), Wilsgaard, T. (Tom), Wojczynski, M.K. (Mary ), Wong, A. (Andrew), Zhang, Q. (Qunyuan), Zhao, J.H. (Jing Hua), Brennan, E.P. (Eoin P.), Choi, M. (Murim), Eriksson, P. (Per), Folkersen, L. (Lasse), Franco-Cereceda, A. (Anders), Gharavi, A.G. (Ali G.), Hedman, A.K. (Asa), Hivert, M.-F. (Marie-France), Huang, J. (Jinyan), Kanoni, S. (Stavroula), Karpe, F. (Fredrik), Keildson, S. (Sarah), Kiryluk, K. (Krzysztof), Liang, L. (Liming), Lifton, R.P. (Richard), Ma, B. (Baoshan), McKnight, A.J. (Amy J.), McPherson, R. (Ruth), Metspalu, A. (Andres), Min, J.L. (Josine L.), Moffatt, M.F. (Miriam), Montgomery, G.W. (Grant), Murabito, J. (Joanne), Nicholson, G. (Ggeorge), Dimas, A.S. (Antigone), Olsson, C. (Christian), Perry, J.R.B. (John), Reinmaa, E. (Eva), Salem, R.M. (Rany), Sandholm, N. (Niina), Schadt, E.E. (Eric), Scott, R.A. (Robert), Stolk, L. (Lisette), Vallejo, E.E. (Edgar E.), Westra, H.J. (Harm-Jan), Zondervan, K.T. (Krina), Amouyel, P. (Philippe), Arveiler, D. (Dominique), Bakker, S.J.L. (Stephan), Beilby, J.P. (John), Bergman, R.N. (Richard), Blangero, J. (John), Brown, M.J. (Morris), Burnier, M. (Michel), Campbell, H. (Harry), Chakravarti, A. (Aravinda), Chines, P.S. (Peter), Claudi-Boehm, S. (Simone), Collins, F.S. (Francis), Crawford, D.C. (Dana), Danesh, J. (John), Faire, U. (Ulf) de, Geus, E.J.C. (Eco) de, Dörr, M. (Marcus), Erbel, R. (Raimund), Hagen, K. (Knut), Farrall, M. (Martin), Ferrannini, E. (Ele), Ferrieres, J. (Jean), Forouhi, N.G. (Nita), Forrester, T. (Terrence), Franco, O.H. (Oscar), Gansevoort, R.T. (Ron), Gieger, C. (Christian), Gudnason, V. (Vilmundur), Haiman, C.A. (Christopher), Harris, T.B. (Tamara), Hattersley, A.T. (Andrew), Heliovaara, M. (Markku), Hicks, A.A. (Andrew), Hingorani, A. (Aroon), Hoffmann, W. (Wolfgang), Hofman, A. (Albert), Homuth, G. (Georg), Humphries, S.E. (Steve), Hypponen, E. (Elina), Illig, T. (Thomas), Jarvelin, M.-R. (Marjo-Riitta), Johansen, B. (Berit), Jousilahti, P. (Pekka), Jula, A. (Antti), Kaprio, J. (Jaakko), Kee, F. (F.), Keinanen-Kiukaanniemi, S. (Sirkka), Kooner, J.S. (Jaspal S.), Kooperberg, C. (Charles), Kovacs, P. (Peter), Kraja, A. (Aldi), Kumari, M. (Meena), Kuulasmaa, K. (Kari), Kuusisto, J. (Johanna), Lakka, T.A. (Timo), Langenberg, C. (Claudia), Le Marchand, L. (Loic), Lehtimäki, T. (Terho), Lyssenko, V. (Valeriya), Männistö, S. (Satu), Marette, A. (Andre'), Matise, T.C. (Tara C.), McKenzie, C.A. (Colin A.), McKnight, B. (Barbara), Musk, A.W. (Arthur), Möhlenkamp, S. (Stefan), Morris, A.D. (Andrew), Nelis, M. (Mari), Ohlsson, C. (Claes), Oldehinkel, A.J. (Albertine), Ong, K.K. (Ken K.), Penninx, B.W.J.H. (Brenda), Peters, A. (Annette), Pramstaller, P.P. (Peter Paul), Raitakari, O. (Olli), Rankinen, T. (Tuomo), Rao, D.C. (Dabeeru C.), Rice, T.K. (Treva K.), Ridker, P.M. (Paul), Ritchie, M.D. (Marylyn D.), Rudan, I. (Igor), Salomaa, V. (Veikko), Samani, N.J. (Nilesh), Saramies, J. (Jouko), Sarzynski, M.A. (Mark A.), Schwarz, P.E.H. (Peter E. H.), Shuldiner, A.R. (Alan), Staessen, J.A. (Jan), Steinthorsdottir, V. (Valgerdur), Stolk, R.P. (Ronald), Strauch, K. (Konstantin), Tönjes, A. (Anke), Tremblay, A. (Angelo), Tremoli, E. (Elena), Vohl, M.-C. (Marie-Claude), Völker, U. (Uwe), Vollenweider, P. (Peter), Wilson, J.F. (James F), Witteman, J.C.M. (Jacqueline), Adair, L.S. (Linda), Bochud, M. (Murielle), Boehm, B.O. (Bernhard), Bornstein, S.R. (Stefan R.), Bouchard, C. (Claude), Cauchi, S. (Ste'phane), Caulfield, M. (Mark), Chambers, J.C. (John C.), Chasman, D.I. (Daniel), Cooper, R.S. (Richard S.), Dedoussis, G.V. (George), Ferrucci, L. (Luigi), Froguel, P. (Philippe), Grabe, H.J. (Hans Jörgen), Hamsten, A. (Anders), Hui, J. (Jennie), Hveem, K. (Kristian), Jöckel, K.-H. (Karl-Heinz), Kivimaki, M. (Mika), Kuh, D. (Diana), Laakso, M. (Markku), Liu, Y. (YongMei), März, W. (Winfried), Munroe, P. (Patricia), Njølstad, I. (Inger), Oostra, B.A. (Ben), Palmer, C.N.A. (Colin), Pedersen, N.L. (Nancy L.), Perola, M. (Markus), Perusse, L. (Louis), Peters, U. (Ulrike), Power, C. (Christopher), Quertermous, T. (Thomas), Rauramaa, R. (Rainer), Rivadeneira Ramirez, F. (Fernando), Saaristo, T. (Timo), Saleheen, D., Sinisalo, J. (Juha), Slagboom, P.E. (Eline), Snieder, H. (Harold), Spector, T.D. (Timothy), Thorsteinsdottir, U. (Unnur), Stumvoll, M. (Michael), Tuomilehto, J. (Jaakko), Uitterlinden, A.G. (André), Uusitupa, M. (Matti), Harst, P. (Pim) van der, Veronesi, G. (Giovanni), Walker, M. (Mark), Wareham, N.J. (Nick), Watkins, H. (Hugh), Wichmann, H.E. (Heinz Erich), Abecasis, G.R. (Gonçalo), Assimes, T.L. (Themistocles), Berndt, S.I. (Sonja), Boehnke, M. (Michael), Borecki, I.B. (Ingrid), Deloukas, P. (Panagiotis), Franke, L. (Lude), Frayling, T.M. (Timothy), Groop, L. (Leif), Hunter, D. (David), Kaplan, R.C. (Robert), O´Connell, J.R., Qi, L. (Lu), Schlessinger, D. (David), Strachan, D.P. (David), Zwart, J-A. (John-Anker), Duijn, C.M. (Cornelia) van, Willer, C.J. (Cristen), Visscher, P.M. (Peter), Yang, J. (Joanna), Hirschhorn, J.N. (Joel N.), Zillikens, M.C. (Carola), McCarthy, M.I. (Mark), Speliotes, E.K. (Elizabeth), North, K.E. (Kari), Fox, C.S. (Caroline S.), Barroso, I.E. (Inês), Franks, P.W. (Paul), Anderson, D. (Denise), Ingelsson, E. (Erik), Heid, I.M. (Iris), Loos, R.J.F. (Ruth), Cupples, L.A. (Adrienne), Morris, A.P. (Andrew), Lindgren, C.M. (Cecilia), and Mohlke, K.L. (Karen)
- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10-8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
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46. Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
- Author
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Draisma, G. (Gerrit), Pool, R. (Reńe), Kobl, M. (Michael), Jansen, R. (Rick), Petersen, A.K., Vaarhorst, A.A.M. (Anika), Yet, I. (Idil), Haller, T. (Toomas), Demirkan, A. (Ayşe), Esko, T. (Tõnu), Zhu, G. (Gu), Böhringer, S. (Stefan), Beekman, M. (Marian), Klinken, J.B. (Jan Bert) van, Römisch-Margl, W. (Werner), Prehn, C. (Cornelia), Adamski, J. (Jerzy), De Craen, A.J.M. (Anton J. M.), Leeuwen, E.M. (Elisa) van, Amin, N. (Najaf), Dharuri, H. (Harish), Westra, H.J. (Harm-Jan), Franke, L. (Lude), Geus, E.J.C. (Eco) de, Hottenga, J.J. (Jouke Jan), Willemsen, G.A.H.M. (Gonneke), Henders, A.K. (Anjali), Montgomery, G.W. (Grant), Dimas, A.S. (Antigone), Whitfield, J.B. (John B.), Penninx, B.W.J.H. (Brenda), Spector, T.D. (Timothy), Metspalu, A. (Andres), Slagboom, P.E. (Eline), Van Dijk, K.W. (Ko Willems), Hoen, P.A.C. (Peter) 't, Strauch, K. (Konstantin), Martin, N.G. (Nicholas), Ommen, G.J. (Gert) van, Illig, T. (Thomas), Bell, J.T. (Jordana), Mangino, M. (Massimo), Suhre, K. (Karsten), McCarthy, M.I. (Mark), Gieger, C. (Christian), Isaacs, A. (Aaron), Duijn, C.M. (Cornelia) van, Boomsma, D.I. (Dorret), Draisma, G. (Gerrit), Pool, R. (Reńe), Kobl, M. (Michael), Jansen, R. (Rick), Petersen, A.K., Vaarhorst, A.A.M. (Anika), Yet, I. (Idil), Haller, T. (Toomas), Demirkan, A. (Ayşe), Esko, T. (Tõnu), Zhu, G. (Gu), Böhringer, S. (Stefan), Beekman, M. (Marian), Klinken, J.B. (Jan Bert) van, Römisch-Margl, W. (Werner), Prehn, C. (Cornelia), Adamski, J. (Jerzy), De Craen, A.J.M. (Anton J. M.), Leeuwen, E.M. (Elisa) van, Amin, N. (Najaf), Dharuri, H. (Harish), Westra, H.J. (Harm-Jan), Franke, L. (Lude), Geus, E.J.C. (Eco) de, Hottenga, J.J. (Jouke Jan), Willemsen, G.A.H.M. (Gonneke), Henders, A.K. (Anjali), Montgomery, G.W. (Grant), Dimas, A.S. (Antigone), Whitfield, J.B. (John B.), Penninx, B.W.J.H. (Brenda), Spector, T.D. (Timothy), Metspalu, A. (Andres), Slagboom, P.E. (Eline), Van Dijk, K.W. (Ko Willems), Hoen, P.A.C. (Peter) 't, Strauch, K. (Konstantin), Martin, N.G. (Nicholas), Ommen, G.J. (Gert) van, Illig, T. (Thomas), Bell, J.T. (Jordana), Mangino, M. (Massimo), Suhre, K. (Karsten), McCarthy, M.I. (Mark), Gieger, C. (Christian), Isaacs, A. (Aaron), Duijn, C.M. (Cornelia) van, and Boomsma, D.I. (Dorret)
- Abstract
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platfo
- Published
- 2015
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47. ABATACEPT TO SILENCE ANTI-CITRULLINATED PROTEIN ANTIBODY-EXPRESSING B CELLS IN RHEUMATOID ARTHRITIS: THE ASCARA TRIAL.
- Author
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Blomberg, N., Kwekkeboom, J., Böhringer, S., Huizinga, T., Toes, R., and Scherer, H. U.
- Published
- 2023
- Full Text
- View/download PDF
48. Discriminating between putative epigenetic osteoarthritis disease drivers and sheer markers
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Hollander, W. den, primary, Ramos, Y.F., additional, Bomer, N., additional, Elzinga, S., additional, Breggen, R. van der, additional, Lakenberg, N., additional, de Dijcker, W.J., additional, Suchiman, E.H., additional, Duijnisveld, B.J., additional, Böhringer, S., additional, Houwing-Duistermaat, J.J., additional, Slagboom, E.P., additional, Bos, S.D., additional, Nelissen, R.G., additional, and Meulenbelt, I., additional
- Published
- 2015
- Full Text
- View/download PDF
49. Data storage layout and architecture of the German T1
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Ressmann, D., Böhringer, S., Halstenberg, S., and Wezel, J. van
- Subjects
DATA processing & computer science ,ddc:004 - Published
- 2007
- Full Text
- View/download PDF
50. Matching of the minor Histocompatibility antigen HLA-A1/H-Y and HA-3 may improve prognosis in corneal transplantation
- Author
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Böhringer, D., Spierings, E., Enczmann, J., Böhringer, S., Sundmacher, R., Goulmy, E.A.J.M., and Reinhard, T.
- Published
- 2006
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