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1. Asthma is associated with increased severity and duration of rhinitis: A study with the Allergic Rhinitis and its Impact on Asthma classes in the Constances cohort

Author: Marine Savouré, Jean Bousquet, Bénédicte Leynaert, Céline Ribet, Marcel Goldberg, Marie Zins, Bénédicte Jacquemin, and Rachel Nadif
Subjects: ARIA, asthma, duration, rhinitis, severity, Immunologic diseases. Allergy, RC581-607
Abstract: Abstract Background Few population‐based studies have described allergic rhinitis (AR) according to the Allergic Rhinitis and its Impact on Asthma (ARIA) classification, and none have assessed the impact of asthma on this classification. Our aims were to 1) describe AR according to four ARIA classes and 2) within each of the four ARIA classes, compare participants with AR alone versus those with AR and asthma. Methods Cross‐sectional analyses were performed using data from the 2014 annual follow‐up questionnaire of the French adult population‐based cohort Constances. Current AR was defined by the report of sneezing, runny, or blocked nose in the last 12 months and the report of nasal allergies. Following ARIA recommendations, rhinitis was classified according to its severity (mild or moderate‐severe) and duration (intermittent or persistent). Ever asthma was also defined by a questionnaire. Results Among the 4675 participants with AR (57% women, mean age 50.2 ± 12.7 years), 44% were classified as mild/intermittent, 16% mild/persistent, 25% moderate‐severe/intermittent, and 15% moderate‐severe/persistent. Within each of the four ARIA classes, compared to participants with rhinitis alone, participants with rhinitis and asthma had significantly more severe symptoms, more conjunctivitis, a higher mean eosinophil count and more treatments with intra‐nasal corticosteroids and oral antihistamines co‐medication. Conclusions This is a paradigm shift study as for the first time this large population‐based study in adults showed that asthma status has a profound effect on the ARIA classification. Rhinitis alone and rhinitis with asthma represent two distinct phenotypes. These results reinforce the need to include asthma status in the ARIA classification and guidelines.
Published: 2023
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2. Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adultsResearch in context

Author: Tianyu Zhao, Iana Markevych, Elaine Fuertes, Kees de Hoogh, Simone Accordini, Anne Boudier, Lidia Casas, Bertil Forsberg, Judith Garcia Aymerich, Marco Gnesi, Mathias Holm, Christer Janson, Deborah Jarvis, Ane Johannessen, Rudolf A. Jörres, Stefan Karrasch, Benedicte Leynaert, José Antonio Maldonado Perez, Andrei Malinovschi, Jesús Martínez-Moratalla, Lars Modig, Dennis Nowak, James Potts, Nicole Probst-Hensch, José Luis Sánchez-Ramos, Valerie Siroux, Isabel Urrutia Landa, Danielle Vienneau, Simona Villani, Bénédicte Jacquemin, and Joachim Heinrich
Subjects: Air pollution, NDVI, Spirometry, Vital capacity, Forced expiratory volume, Middle aged, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. Methods: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM2.5, NO2, and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age. Findings: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV1 of −2.08 mL/year (95% confidence interval: −2.79, −1.36) and in FVC of −2.86 mL/year (−3.73, −1.99) mL/year over the study period. Associations were robust after adjusting for PM2.5, NO2, and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV1/FVC ratio. Interpretation: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period. Funding: German Research Foundation.
Published: 2023
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3. Long-term exposure to airborne metals and risk of cancer in the French cohort Gazel

Author: Emeline Lequy, Sébastien Leblond, Jack Siemiatycki, Caroline Meyer, Danielle Vienneau, Kees de Hoogh, Marie Zins, Marcel Goldberg, and Bénédicte Jacquemin
Subjects: Arsenic, Cadmium, Moss biomonitoring, Survival analysis, Gazel cohort, Environmental sciences, GE1-350
Abstract: Background: The specific compounds that make ambient fine particulate matter (PM2.5) carcinogen remain poorly identified. Some metals contribute to ambient PM2.5 and possibly to its adverse effects. But the challenge of assessing exposure to airborne metals limits epidemiological studies. Objective: To analyze the relationships between several airborne metals and risk of cancer in a large population. Methods: We estimated the individual exposure to 12 airborne metals of ∼ 12,000 semi-urban and rural participants of the French population-based Gazel cohort using moss biomonitoring data from a 20-year national program. We used principal component analyses (PCA) to derive groups of metals, and focused on six single carcinogenic or toxic metals (arsenic, cadmium, chromium, lead, nickel, and vanadium). We used extended Cox models with attained age as time-scale and time-varying weighted average exposures, adjusted for individual and area-level covariables, to analyze the association between each exposure and all-site combined, bladder, lung, breast, and prostate cancer incidence. Results: We identified 2,401 cases of all-site cancer between 2001 and 2015. Over the follow-up, median exposures varied from 0.22 (interquartile range (IQR): 0.18–0.28) to 8.68 (IQR: 6.62–11.79) µg.g−1 of dried moss for cadmium and lead, respectively. The PCA yielded three groups identified as “anthropogenic”, “crustal”, and “marine”. Models yielded positive associations between most single and groups of metal and all-site cancer, with e.g. hazard ratios of 1.08 (95% CI: 1.03, 1.13) for cadmium or 1.06 (95% CI: 1.02,1.10) for lead, per interquartile range increase. These findings were consistent across supplementary analyses, albeit attenuated when accounting for total PM2.5. Regarding specific site cancers, we estimated positive associations mostly for bladder, and generally with large confidence intervals. Conclusion: Most single and groups of airborne metals, except vanadium, were associated with risk of cancer. These findings may help identify sources or components of PM2.5 that may be involved in its carcinogenicity.
Published: 2023
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4. The effect of short term exposure to outdoor air pollution on fertility

Author: Mireia González-Comadran, Bénédicte Jacquemin, Marta Cirach, Rafael Lafuente, Thomas Cole-Hunter, Mark Nieuwenhuijsen, Mario Brassesco, Buenaventura Coroleu, and Miguel Angel Checa
Subjects: Acute exposure, Particulate matter, Nitrogen dioxide, PM2.5, PM10, NO2, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract: Abstract Background There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable. Methods This prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM2.5 [particulate matter (PM) ≤2.5 μm], PMcoarse (PM between 2.5 and 10μm), PM10 (PM≤10 μm), PM2.5 abs, and NO2 and NOx. Outcomes were analyzed using multi-level regression models, with adjustment for co-pollutants and confouding factors. Two sensitivity analyses were performed. First, the model was adjusted for subacute exposure (received 15 days before ET). The second analysis was based on the first transfer performed on each patient aiming to exclude patients who failed previous transfers. Results One hundred ninety-four women were recruited, contributing with data for 486 embryo transfers. Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM2.5 exposure on 3D after adjusting for subacute exposure, and an increased risk of achieving no pregnancy for PM2.5, PMcoarse and PM10 on 3D. The second sensitivity analysis showed a significant risk of miscarriage for PM2.5 exposure on 3D, and a significant risk of achieving no pregnancy for PM2.5, PMcoarse and PM10 particularly on 3D. No association was observed for nitrogen dioxides on reproductive outcomes. Conclusions Exposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.
Published: 2021
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5. Ambient air pollution exposure and depressive symptoms: Findings from the French CONSTANCES cohort

Author: Mohammad Javad Zare Sakhvidi, Antoine Lafontaine, Emeline Lequy, Claudine Berr, Kees de Hoogh, Danielle Vienneau, Marcel Goldberg, Marie Zins, Cédric Lemogne, and Bénédicte Jacquemin
Subjects: Particulate matter, Black carbon, Nitrogen dioxide, Depression, Mental health, CONSTANCES cohort, Environmental sciences, GE1-350
Abstract: Background and Aim: Few studies have reported the association between air pollution exposure with different dimensions of depression. We aimed to explore this association across different dimensions of depressive symptoms in a large population. Methods: Data from the enrollment phase of the French CONSTANCES cohort (2012–2020) were analyzed cross-sectionally. Annual concentrations of particulate matter with a diameter
Published: 2022
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6. Exposure to ambient air pollution and cognitive decline: Results of the prospective Three-City cohort study

Author: Jeanne Duchesne, Laure-Anne Gutierrez, Isabelle Carrière, Thibault Mura, Jie Chen, Danielle Vienneau, Kees de Hoogh, Catherine Helmer, Bénédicte Jacquemin, Claudine Berr, and Marion Mortamais
Subjects: Air pollution, Cognition, Cohort, Particulate matter, Nitrogen dioxide, Black carbon, Environmental sciences, GE1-350
Abstract: Background: Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive decline. However, there is still some heterogeneity in the findings, with inconsistent results depending on the pollutant and the cognitive domain considered. We wanted to determine whether air pollution was associated with global and domain-specific cognitive decline. Methods: This analysis used data from the French Three-City prospective cohort (participants aged 65 and older at recruitment and followed for up to 12 years). A battery of cognitive tests was administered at baseline and every 2 years, to assess global cognition (Mini Mental State Examination, MMSE), visual memory (Benton Visual Retention Test), semantic fluency (Isaacs Set Test) and executive functions (Trail Making Tests A and B). Exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2) and black carbon (BC) at the participants’ residential address during the 5 years before the baseline visit was estimated with land use regression models. Linear mixed models and latent process mixed models were used to assess the association of each pollutant with global and domain-specific cognitive decline. Results: The participants’ (n = 6380) median age was 73.4 years (IQR: 8.0), and 61.5% were women. At baseline, the median MMSE score was 28 (IQR: 3). Global cognition decline, assessed with the MMSE, was slightly accelerated among participants with higher PM2.5 exposure: one IQR increment in PM2.5 (1.5 µg/m3) was associated with accelerated decline (β: −0.0060 [−0.0112; −0.0007] standard unit per year). Other associations were inconsistent in direction, and of small magnitude. Conclusion: In this large population-based cohort, higher PM2.5 exposure was associated with accelerated global cognition decline. We did not detect any significant association for the specific cognitive domains or the other pollutants. Evidence concerning PM2.5 effects on cognition is growing, but more research is needed on other ambient air pollutants.
Published: 2022
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7. Worldwide prevalence of rhinitis in adults: A review of definitions and temporal evolution

Author: Marine Savouré, Jean Bousquet, Jouni J. K. Jaakkola, Maritta S. Jaakkola, Bénédicte Jacquemin, and Rachel Nadif
Subjects: rinitis alérgica, epidemiología, rinitis no alérgica, prevalencia, rinitis, Immunologic diseases. Allergy, RC581-607
Abstract: Abstract Introduction Although rhinitis is among the most common diseases worldwide, rhinitis prevalence in the general adult population is unclear and definitions differ widely. Objective To summarize the literature on rhinitis prevalence in the general adult population and to assess: (1) the prevalence according to different rhinitis definitions overall and in different regions of the world, and (2) the evolution of rhinitis prevalence over time. Methods We conducted an extensive literature review of publications including rhinitis prevalence using Pubmed and Scopus databases up to October 2020. We classified the definitions into three categories: unspecified rhinitis, allergic rhinitis (AR), and nonallergic rhinitis (NAR). Results Among 5878 articles screened, 184 articles were included, presenting 156 different definitions of rhinitis. Rhinitis prevalence ranged from 1% to 63%. The overall median prevalences of unspecified rhinitis, AR and NAR were 29.4%, 18.1% and 12.0%, and they varied according to the geographical location. Rhinitis prevalence tended to increase over time. Conclusions This review highlights the great heterogeneity of the definitions. The majority of studies had focused on AR, while only a few epidemiological data exist on NAR. We found geographical variability in rhinitis prevalence. Most of studies reported an increase of rhinitis prevalence over the last decades.
Published: 2022
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8. Long-term exposure to black carbon and mortality: A 28-year follow-up of the GAZEL cohort

Author: Jun Yang, Mohammad Javad Zare Sakhvidi, Kees de Hoogh, Danielle Vienneau, Jack Siemiatyck, Marie Zins, Marcel Goldberg, Jie Chen, Emeline Lequy, and Bénédicte Jacquemin
Subjects: Air pollutant, Black carbon, Mortality, Long-term exposure, Cohort study, Environmental sciences, GE1-350
Abstract: Background: The current evidence on health effects of long-term exposure to outdoor airborne black carbon (BC) exposure remains scarce. Objectives: To examine the association between long-term exposure to BC and mortality in a large population-based French cohort, with 28 years of follow-up. Methods: Data from the GAZEL cohort were collected between 1989 and 2017. Land use regression model with temporal extrapolation wa used to estimate yearly BC and PM2.5 exposure at the residential addresses from 1989 until censoring for 19,906 participants. Time-varying Cox models with attained age as time-scale was used to estimate the associations between BC and all-cause and cardiovascular mortality, after adjusting for individual and area-level covariates. To handle confounding by PM2.5, we used the residual of BC regressed on PM2.5 as an alternate exposure variable. For all-cause mortality, we also examined effect modification by sex, smoking status, BMI and fruit/vegetable intake. Results: The median of 20-year moving average of BC exposure was 2.02 10−5/m in study population. We found significant associations between BC exposure and all-cause mortality (n = 2357) using both 20-year moving average of BC and residual of BC, with corresponding hazard ratios (HR) of 1.14 (95 %CI: 1.07–1.22) and 1.17 (95 %CI: 1.10–1.24) for an inter-quartile range (IQR) increase (0.86 10−5/m for BC and 0.57 10−5/m for residual of BC). We found a similar association between BC and cardiovascular mortality (n = 277) with a HR of 1.15 (95 %CI: 0.95–1.38). The dose–response relationship between BC and all-cause mortality was monotonic but nonlinear with a steeper slope at high BC levels. In addition, the effect of BC was higher among never-smokers and among those having fruit/vegetables less than twice a week. Conclusions: There was a positive association between long-term exposure to BC and increased mortality risk, reinforcing the emerging evidence that BC is a harmful component of PM2.5.
Published: 2021
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9. Long-term exposures to PM2.5, black carbon and NO2 and prevalence of current rhinitis in French adults: The Constances Cohort

Author: Marine Savouré, Émeline Lequy, Jean Bousquet, Jie Chen, Kees de Hoogh, Marcel Goldberg, Danielle Vienneau, Marie Zins, Rachel Nadif, and Bénédicte Jacquemin
Subjects: Air pollution, Rhinitis, Epidemiology, Black carbon, Environmental sciences, GE1-350
Abstract: Background: Rhinitis is one of the most common disease worldwide with a high and increasing prevalence. There is limited knowledge on the link between long-term exposure to air pollution and rhinitis. Objectives: We aim to study the associations between long-term exposure to air pollutants and self-reported current rhinitis among adults from Constances, a large French population-based cohort. Methods: Current rhinitis was defined at inclusion from questionnaire by the presence of sneezing, runny or blocked nose in the last 12 months without a cold or the flu. Annual concentrations of nitrogen dioxide (NO2), particulate matter ≤ 2.5 µm (PM2.5) and black carbon (BC) were estimated at the participants' residential address by European land-use regression models. Cross-sectional associations between annual exposure to each air pollutant and current rhinitis were estimated using logistic models adjusted for age, sex, smoking, education level and French deprivation index. The health prevention centers were taken into account by marginal models with generalized estimating equations. Several supplementary analyses were performed. Results: Analyses were performed on 127,108 participants (47 years old on average, 54% women, 19% current smokers). The prevalence of current rhinitis, allergic (AR) and non-allergic (NAR) rhinitis were 36%, 25% and 11% respectively. Adjusted ORs for current rhinitis were 1.13 (1.08, 1.17), 1.12 (1.07, 1.17), and 1.11 (1.06, 1.17) per one interquartile range increase of PM2.5 (4.85 µg/m3), BC (0.88 · 10−5 m−1) and NO2 (17.3 µg/m3) respectively. Significant and positive associations were also found for both AR and NAR. Results were similar in men and women, and in the different smoking strata, and were consistent with meta-analysis or after imputing missing covariates. Discussion: An increase of modeled annual average residential exposure to PM2.5, BC, and NO2 was significantly associated with an increase of prevalence of current rhinitis in adults in the French general population. The results suggest that among air pollutants, BC may be of special interest.
Published: 2021
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10. Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

Author: Anaïs Havet, Zhen Li, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Nino Künzli, Bénédicte Jacquemin, Raphaëlle Varraso, Régis Matran, and Rachel Nadif
Subjects: Epidemiology, Outdoor air pollution, Persistent asthma, Oxidative stress, Fluorescent oxidation products, Mediation analysis, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract: Abstract Background Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma. Methods Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003–2007) and EGEA3 (follow-up, 2011–2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM10) and ≤ 2.5 μm were estimated by ESCAPE models (2009–2010), and ozone (O3) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution. Results FlOPs levels increased with PM10 and O3 (adjusted β = 0.04 (95%CI 0.001–0.08), aβ = 0.04 (95%CI 0.009–0.07) per 10 μg/m3, respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08–3.02)). The risk of persistent asthma decreased with exposures to NO2, NOx and PM2.5 (aOR ranging from 0.62 to 0.94), and increased with exposures to PM10, O3, O3-summer and road traffic, the greater effect being observed for O3 (aOR = 1.78, 95% CI 0.73–4.37, per 10 μg/m3). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70–11.9), a positive direct effect of O3 on persistent asthma (OR = 1.68, 95%CI 0.57–7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01–2.29)) accounting for 41% of the total effect. Conclusions Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.
Published: 2019
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11. Long-term exposure to atmospheric metals assessed by mosses and mortality in France

Author: Emeline Lequy, Jack Siemiatycki, Sébastien Leblond, Caroline Meyer, Sergey Zhivin, Danielle Vienneau, Kees de Hoogh, Marcel Goldberg, Marie Zins, and Bénédicte Jacquemin
Subjects: Environmental sciences, GE1-350
Abstract: Background: Long-term exposure to air pollution affects health, but little is known about exposure to atmospheric metals. Estimating exposure to atmospheric metals across large spatial areas remains challenging. Metal concentrations in mosses could constitute a useful proxy. Here, we linked moss biomonitoring and epidemiological data to investigate the associations between long-term exposure to metals and mortality. Methods: We modelled and mapped 13 atmospheric metals from a 20-year national moss biomonitoring program to derive exposure estimates across France. In the population-based Gazel cohort, we included 11,382 participants from low to intermediate population density areas and assigned modelled metals to their residential addresses. We distinguished between airborne metals that are primarily of natural origin and those primarily of anthropogenic origin. Associations were estimated between exposure to metals and mortality (natural-cause, cardiovascular and respiratory), using Cox models, with confounder adjustment at individual level. Findings: Between 1996 and 2017, there were 1313 deaths in the cohort (including 181 cardiovascular and 33 respiratory). Exposure to the anthropogenic metals was associated with an increased risk of natural-cause mortality (hazard ratio of 1.16 [1.08–1.24] per interquartile range of exposure), while metals from natural sources were not. Interpretation: Some atmospheric anthropogenic metals may be associated with excess mortality – even in areas with relatively low levels of exposure to air pollution. Consistent with the previous literature, our findings support the use of moss biomonitoring as a tool to assess health effects of air pollution exposure at individual level.
Published: 2019
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12. Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study

Author: Marion Mortamais, Laure-Anne Gutierrez, Kees de Hoogh, Jie Chen, Danielle Vienneau, Isabelle Carrière, Noémie Letellier, Catherine Helmer, Audrey Gabelle, Thibault Mura, Jordi Sunyer, Tarik Benmarhnia, Bénédicte Jacquemin, and Claudine Berr
Subjects: Cohort, Dementia, Incidence, Elderly, Air pollution, Fine particulate matter, Environmental sciences, GE1-350
Abstract: Background: Emerging epidemiological evidence suggests a relationship between exposure to air pollution and dementia. However, most of the existing studies relied on health administrative databases for the diagnosis of dementia. In a large French population-based cohort (the 3C Study), we assessed the effects of particulate matter ≤2.5 µm (PM2.5), nitrogen dioxide (NO2) and black carbon (BC) on the risk of dementia diagnosed with reliable tools. Methods: Participants aged ≥65 years were recruited between 1999 and 2001 and followed for 12 years. At baseline and every 2 years, dementia was suspected on the basis of the neuropsychological and neurological examination and confirmed by an independent committee of clinicians. Exposure to NO2, BC and PM2.5 at the participants’ residential address was estimated using land use regression models. For each pollutant and year of follow-up, the 10-year moving average of past exposure was estimated. Multilevel spatial random-effects Cox proportional hazards models were used in which exposure was included as a time-varying variable. Analyses were adjusted for individual (age, sex, education, APOE4 genotype, health behaviours) and contextual (neighbourhood deprivation index) confounders. Results: At baseline, the median age of the 7066 participants was 73.4 years, and 62% were women. The median follow-up duration was 10.0 years during which 791 participants developed dementia (n = 541 Alzheimer’s disease (AD) and n = 155 vascular/mixed dementia (VaD)). The 10-year moving average of PM2.5 concentrations ranged from 14.6 to 31.3 µg/m3.PM2.5 concentration was positively associated with dementia risk: HR = 1.20, 95% CI (1.08–1.32) for all-cause dementia, 1.20 (1.09–1.32) for AD, and 1.33 (1.05–1.68) for VaD per 5 µg/m3 PM2.5 increase. No association was detected between NO2 or BC exposure and dementia risk. Conclusion: In this large cohort of older adults, long-term PM2.5 exposure was associated with increased dementia incidence. Reducing PM2.5 emissions might lessen the burden of dementia in aging populations.
Published: 2021
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13. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts

Author: Elaine Fuertes, Jordi Sunyer, Ulrike Gehring, Daniela Porta, Francesco Forastiere, Giulia Cesaroni, Martine Vrijheid, Mònica Guxens, Isabella Annesi-Maesano, Rémy Slama, Dieter Maier, Manolis Kogevinas, Jean Bousquet, Leda Chatzi, Aitana Lertxundi, Mikel Basterrechea, Ana Esplugues, Amparo Ferrero, John Wright, Dan Mason, Rosie McEachan, Judith Garcia-Aymerich, and Bénédicte Jacquemin
Subjects: Environmental sciences, GE1-350
Abstract: Background: Uncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades. Objective: We examined associations of long-term air pollution levels at the home address with pediatric eczema, rhinoconjunctivitis and asthma prevalences in five birth cohorts (BIB, EDEN, GASPII, RHEA and INMA) from seven areas in five European countries. Methods: Current eczema, rhinoconjunctivitis and asthma were assessed in children aged four (N = 6527) and eight years (N = 2489). A multi-morbidity outcome (≥2 conditions versus none) was also defined. Individual outdoor levels of nitrogen dioxide (NO2), nitrogen oxides, mass of particulate matter with an aerodynamic diameter
Published: 2020
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14. Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study

Author: Elaine Fuertes, Iana Markevych, Deborah Jarvis, Danielle Vienneau, Kees de Hoogh, Josep Maria Antó, Gayan Bowatte, Roberto Bono, Angelo G. Corsico, Margareta Emtner, Thorarinn Gislason, José Antonio Gullón, Joachim Heinrich, John Henderson, Mathias Holm, Ane Johannessen, Bénédicte Leynaert, Alessandro Marcon, Pierpaolo Marchetti, Jesús Martínez Moratalla, Silvia Pascual, Nicole Probst-Hensch, José Luis Sánchez-Ramos, Valerie Siroux, Johan Sommar, Joost Weyler, Nino Kuenzli, Bénédicte Jacquemin, and Judith Garcia-Aymerich
Subjects: Environmental sciences, GE1-350
Abstract: Background: Very few studies have examined whether a long-term beneficial effect of physical activity on lung function can be influenced by living in polluted urban areas. Objective: We assessed whether annual average residential concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters 75th percentile (high)). Results: Among current smokers, physical activity and lung function were positively associated regardless of air pollution levels. Among never-smokers, physical activity was associated with lung function in areas with low/medium NO2, PM2.5 mass and PM10 mass concentrations (e.g. mean difference in FVC between active and non-active subjects was 43.0 mL (13.6, 72.5), 49.5 mL (20.1, 78.8) and 49.7 mL (18.6, 80.7), respectively), but these associations were attenuated in high air pollution areas. Only the interaction term of physical activity and PM10 mass for FEV1 among never-smokers was significant (p-value = 0.03). Conclusions: Physical activity has beneficial effects on adult lung function in current smokers, irrespective of residential air pollution levels in Western Europe. Trends among never-smokers living in high air pollution areas are less clear. Keywords: Air pollution, Cohort, Lung function, Physical activity, Smoking
Published: 2018
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15. Ability of ecological deprivation indices to measure social inequalities in a French cohort

Author: Sofia Temam, Raphaëlle Varraso, Carole Pornet, Margaux Sanchez, Aurélie Affret, Bénédicte Jacquemin, Françoise Clavel-Chapelon, Grégoire Rey, Stéphane Rican, and Nicole Le Moual
Subjects: Socioeconomic factors, Deprivation index, Social inequalities, Public aspects of medicine, RA1-1270
Abstract: Abstract Background Despite the increasing interest in place effect to explain health inequalities, there is currently no consensus on which kind of area-based socioeconomic measures researchers should use to assess neighborhood socioeconomic position (SEP). The study aimed to evaluate the reliability of different area-based deprivation indices (DIs) in capturing socioeconomic residential conditions of French elderly women cohort. Methods We assessed area-based SEP using 3 DIs: Townsend Index, French European Deprivation Index (FEDI) and French Deprivation index (FDep), among women from E3N (Etude épidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale). DIs were derived from the 2009 French census at IRIS level (smallest geographical units in France). Educational level was used to evaluate individual-SEP. To evaluate external validity of the 3 DIs, associations between two well-established socially patterned outcomes among French elderly women (smoking and overweight) and SEP, were compared. Odd ratios were computed with generalized estimating equations to control for clustering effects from participants within the same IRIS. Results The analysis was performed among 63,888 women (aged 64, 47% ever smokers and 30% overweight). Substantial agreement was observed between the two French DIs (Kappa coefficient = 0.61) and between Townsend and FEDI (0.74) and fair agreement between Townsend and FDep (0.21). As expected among French elderly women, those with lower educational level were significantly less prone to be ever smoker (Low vs. High; OR [95% CI] = 0.43 [0.40–0.46]) and more prone to being overweight (1.89 [1.77–2.01]) than women higher educated. FDep showed expected associations at area-level for both smoking (most deprived vs. least deprived quintile; 0.77 [0.73–0.81]) and overweight (1.52 [1.44–1.62]). For FEDI opposite associations with smoking (1.13 [1.07–1.19]) and expected association with overweight (1.20 [1.13–1.28]) were observed. Townsend showed opposite associations to those expected for both smoking and overweight (1.51 [1.43–1.59]; 0.93 [0.88–0.99], respectively). Conclusion FDep seemed reliable to capture socioeconomic residential conditions of the E3N women, more educated in average than general French population. Results varied strongly according to the DI with unexpected results for some of them, which suggested the importance to test external validity before studying social disparities in health in specific populations.
Published: 2017
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16. Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study.

Author: Emilie Burte, Jean Bousquet, Raphaëlle Varraso, Frédéric Gormand, Jocelyne Just, Régis Matran, Isabelle Pin, Valérie Siroux, Bénédicte Jacquemin, and Rachel Nadif
Subjects: Medicine, Science
Abstract: The classification of rhinitis in adults is missing in epidemiological studies.To identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used. Allergic sensitization was defined by at least one positive skin prick test to 12 aeroallergens. Mixture model was used to cluster participants, independently in those without (Asthma-, n = 582) and with asthma (Asthma+, n = 401).Three clusters were identified in both groups: 1) Cluster A (55% in Asthma-, and 22% in Asthma+) mainly characterized by the absence of nasal symptoms, 2) Cluster B (23% in Asthma-, 36% in Asthma+) mainly characterized by nasal symptoms all over the year, sinusitis and a low prevalence of positive skin prick tests, and 3) Cluster C (22% in Asthma-, 42% in Asthma+) mainly characterized by a peak of nasal symptoms during spring, a high prevalence of positive skin prick tests and a high report of hay fever, allergic rhinitis and conjunctivitis. The highest rate of polysensitization (80%) was found in participants with comorbid asthma and allergic rhinitis.This cluster analysis highlighted three clusters of rhinitis with similar characteristics than those known by clinicians but differing according to allergic sensitization, and this whatever the asthma status. These clusters could be easily rebuilt using a small number of variables.
Published: 2015
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17. Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.

Author: Margaux Sanchez, Jean Bousquet, Nicole Le Moual, Bénédicte Jacquemin, Françoise Clavel-Chapelon, Marc Humbert, Francine Kauffmann, Pascale Tubert-Bitter, and Raphaëlle Varraso
Subjects: Medicine, Science
Abstract: Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could reflect disease variability 2) these patterns may further be classified according to asthma severity/control. Among 70,428 French women, we used seven questionnaires (1992-2005) and a comprehensive reimbursement database (2004-2009) to define three reliable asthma patterns based on repeated positive answers to the ever asthma attack question: "never asthma" (n = 64,061); "inconsistent" ("yes" followed by "no", n = 3,514); "consistent" (fully consistent positive answers, n = 2,853). The "Inconsistent" pattern was related to both long-term (childhood-onset asthma with remission in adulthood) and short-term (reported asthma attack in the last 12 months, associated with asthma medication) asthma variability, showing that repeated questions are relevant markers of the variable expression of asthma. Furthermore, in this pattern, the number of positive responses (1992-2005) predicted asthma drug consumption in subsequent years, a marker of disease severity. The "Inconsistent" pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected.
Published: 2013
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18. Contact with hospital syringes containing body fluids: implications for medical waste management regulation Jeringas en contacto con sangre y fluidos corporales utilizadas en el hospital: implicaciones para el manejo de desechos hospitalarios

Author: Patricia Volkow, Bénédicte Jacquemin, Diana Vilar-Compte, and José Ramón Castillo
Subjects: residuos de hospitales, jeringas, manejo de residuos, México, medical waste, syringes, waste management, Mexico, Public aspects of medicine, RA1-1270
Abstract: OBJECTIVE: To determine amount of syringes used in the hospital and extent of contact with blood and body fluids of these syringes. MATERIAL AND METHODS: Syringe use was surveyed at a tertiary care center for one week; syringes were classified into the following four categories according to use: a) contained blood; b) contained other body fluids (urine, gastric secretion, cerebrospinal fluid, wound drainage); c) used exclusively for drug dilution and application in plastic intravenous (IV) tubes, and d) for intramuscular (IM), subcutaneous (SC), or intradermic (ID) injections. RESULTS: A total of 7 157 plastic disposable syringes was used; 1 227 (17%) contained blood during use, 346 (4.8%), other body fluids, 5 257 (73%) were used exclusively for drug dilution and application in plastic IV lines, and 327 (4.5%) were utilized for IM, SC, or ID injections. An estimated 369 140 syringes used annually, or eight syringes per patient per in-hospital day. All syringes were disposed of as regulated medical waste, in observance of the law. CONCLUSIONS: There is an urgent need to review recommendations for medical waste management by both international agencies and local governments, based on scientific data and a cost-benefit analysis, to prevent resource waste and further environmental damage.OBJETIVO: Cuantificar el número de jeringas que se utilizan en el hospital y calcular cuántas de éstas entran en contacto con sangre o fluidos corporales. MATERIAL Y MÉTODOS: Se hizo una encuesta del uso de jeringas en un hospital de tercer nivel de atención durante toda una semana. Se clasificaron, de acuerdo con el uso que se les dio, en cuatro categorías: a) aspiración de sangre, b) otros fluidos corporales (orina, secreción gástrica, líquido cefalorraquídeo, drenaje de herida, etcétera), c) uso exclusivo para diluir medicamentos y administrarlos a través de tubos de terapia intravenosa, d) para aplicación de inyecciones intramusculares (IM), subcutáneas (SC) o intradérmicas (ID). RESULTADOS: Se utilizó un total de 7 157 jeringas plásticas desechables, 1 227 (17%) de las cuales contuvieron sangre durante su uso, 346 (4.8%) otros líquidos corporales, 5 257 (73%) se usaron exclusivamente para diluir medicamentos y administrarlos mediante tubos de terapia intravenosa, y 327 (4.5%) se usaron para inyecciones IM, SC o ID. El consumo anual de jeringas estimado fue de 369 140, o sea ocho jeringas por paciente por día de hospitalización. Todas las jeringas fueron desechadas como residuo peligroso biológico infeccioso (RPBI) de acuerdo con la Norma -087 Ecol 1995. CONCLUSIONES: Existe una necesidad urgente de revisar las recomendaciones para el manejo de la basura médica regulada, tanto por agencias internacionales como por los gobiernos locales, que deberán basarse en información científica y en un análisis de costo beneficio para evitar el dispendio de recursos y un mayor daño al medio ambiente.
Published: 2003

19. Indoor visible moulds and rhinitis in adults: The <scp>EGEA</scp> study

Author: Laurent Orsi, Marine Savouré, Jean Bousquet, Bénédicte Jacquemin, Valérie Siroux, Maritta S. Jaakkola, Jouni J. K. Jaakkola, Bénédicte Leynaert, Rachel Nadif, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and University of Oulu
Subjects: [SDV]Life Sciences [q-bio], Immunology, Immunology and Allergy
Abstract: International audience
Published: 2022
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20. Contributors

Author: Aram Anto, Josep M Anto, Fabio Balli, Annabelle Bedard, Anna Bedbrook, Jean Bousquet, Luisa Brussino, Pierre-Régis Burgel, Emilie Burte, Carlos A. Camargo, Jr., G Walter Canonica, Tara F. Carr, Thomas Casale, Lidia Casas, Guillaume Chassagnon, Wienczyslawa Czarlewski, Shyamali C. Dharmage, Orianne Dumas, Joao A Fonseca, Mina Gaga, Bilun Gemicioglu, Sven Günther, Stéfanie Habib, Kohei Hasegawa, Joachim Heinrich, N. Sabrina Idrose, Bénédicte Jacquemin, Ludger Klimek, Violeta Kvedariene, Bénédicte Leynaert, Zhen Li, Renaud Louis, Clémence Martin, Andréanne Morin, Nicole Le Moual, Rachel Nadif, Hiroyuki Nagase, Carole Ober, Jean Pastré, Sanjay B. Patel, Francesca Puggioni, Francisco Gómez Real, Nicolas Roche, Joaquin Sastre, Marine Savouré, Nathan Schoettler, Nicola Scichilone, Bernardo Sousa-Pinto, Maho Suzukawa, Laura Toivonen, Arunas Valiulis, Raphaëlle Varraso, Arzu Yorgancioglu, Eleptherios Zervas, and Torsten Zuberbier
Published: 2023
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21. Association between long-term ambient air pollution exposure and handgrip strength change in the French CONSTANCES cohort

Author: Emilie Burte, Mohammad Javad Zare Sakhvidi, Antoine Lafontaine, Emeline Lequy, Fanny Artaud, Claudine Berr, Marianne Canonico, Alexis Elbaz, Kees de Hoogh, Danielle Vienneau, Marcel Goldberg, Marie Zins, and Bénédicte Jacquemin
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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22. Prenatal exposure to traffic-related air pollution and childhood acute leukaemia in France - GEOCAP Birth 2010-2015

Author: Stéphanie GOUJON, Antoine Lafontaine, Bénédicte Jacquemin, and Jacqueline Clavel
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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23. Greenspace exposure and depressive symptoms: findings from the French CONSTANCES cohort

Author: Mohammad Javad Zare Sakhvidi, Antoine Lafontaine, Emeline Lequy, Claudine Berr, Payam Dadvand, Kees de Hoogh, Danielle Vienneau, Marcel Goldberg, Marie Zins, Cédric Lemogne, and Bénédicte Jacquemin
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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24. Association between greenspace exposure and different domains of cognitive function in the French CONSTANCES cohort

Author: Ana Ramos, Mohammad Javad Zare Sakhvidi, Antoine Lafontaine, Payam Dadvand, Kees de Hoogh, Emeline Lequy, Noémie Letellier, Marion Mortamais, Anna Ozguler, Danielle Vienneau, Marcel Goldberg, Marie Zins, Claudine Berr, and Bénédicte Jacquemin
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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25. Pathways associated with air pollution exposure and cognitive outcomes: a systematic review of the epidemiological studies

Author: Mohammad Javad Zare Sakhvidi, Emilie Burte, AmirHoushang Mehrparvar, Marion Mortamais, Noémie Letellier, Claudine Berr, and Bénédicte Jacquemin
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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26. Association between long-term exposure to air pollution and rhinitis and asthma comorbidities in the Constances cohort

Author: Marine Savouré, Emeline Lequy, Jean Bousquet, Kees de Hoogh, Marcel Goldberg, Danielle Vienneau, Marie Zins, Rachel Nadif, Bénédicte Jacquemin, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, French Environment and Energy Management Agency (FEEMA), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Berlin Institute of Health (BIH), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), MASK-air, Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and International Society for Environmental Epidemiology
Subjects: Air pollution, General Earth and Planetary Sciences, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Asthma, General Environmental Science, Rhinitis
Abstract: International audience; BACKGROUND AND AIM - Asthma and rhinitis are two related respiratory conditions. However, studies that investigated their associations with air pollution have considered them separately. We aimed to study the association between exposure to air pollution and phenotypes of current rhinitis (CR) and current asthma (CA) in Constances, a large French population-based adult cohort. METHODS - CR was defined by the report of sneezing, runny or blocked nose in the last 12 months. CA was defined by the report of lifetime asthma plus having in the last 12 months: taken asthma medication or had an asthma attack, wheezed, woken up with breathing discomfort, been short of breath at rest or exercise, or woken up with shortness of breath. Four categories were considered: non-CR/non-CA, CR/non-CA, non-CR/CA, and CR/CA. Annual exposure to nitrogen dioxide (NO2), particulate matter ≤2.5 µm (PM2.5) and black carbon (BC) was estimated at the participants' residential address by land-use regression models. Cross-sectional analyses at inclusion were performed between air pollutants and the four phenotypes using a multinomial logistic model adjusted for age, sex, smoking, education level and French deprivation index. RESULTS - Among the 173,805 participants included in this analysis (mean age: 47, 54% women), 108,637 (63%) were classified as non-CR/non-CA, 48,712 (28%) CR/non-CA, 6,282 (4%) non-CR/CA, and 10,174 (6%) CR/CA. Using non-CR/non-CA as reference, an increase of an interquartile range of BC (0.86 10-5m-1) was significantly associated with CR/non-CA (OR (CI95%): 1.17 (1.15-1.20)), non-CR/CA (1.10 (1.05-1.15)), and CR/CA (1.12 (1.08-1.16)). Similar associations were observed for PM2.5, NO2, and BC residuals. Regardless of pollutant, associations were significantly higher for the CR/non-CA than for the other groups. CONCLUSIONS - Our results suggest that CR/non-CA phenotype may be more sensitive to the effects of air pollution and that among traffic related air pollutants, BC may be of special interest.
Published: 2022
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27. Associations of prenatal exposure to outdoor PM2.5 and NO2 with childhood respiratory symptoms

Author: Alan Ricardo Patlán-Hernández, Etienne Audureau, Johanna Lepeule, Mélanie Bertin, Ralph Epaud, Sophie Lanone, Charline Warembourg, Christine Monfort, Cécile Chevrier, and Bénédicte Jacquemin
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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28. Association between ambient air pollution exposure and plasma β-amyloid levels in the French Three-City study : preliminary results

Author: Jeanne Duchesne, Laure-Anne Gutierrez, Jie Chen, Danielle Vienneau, Kees de Hoogh, Bénédicte Jacquemin, Karen Ritchie, Claudine Berr, and Marion Mortamais
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2022
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29. Exposure to greenspace and cancer incidence, prevalence, and mortality: A systematic review and meta-analyses

Author: Mohammad Javad Zare Sakhvidi, Jun Yang, Amir Houshang Mehrparvar, Angel M. Dzhambov, AliAsghar Ebrahimi, Payam Dadvand, Bénédicte Jacquemin, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Yazd Shahid Sadoughi University of Medical Sciences - SSU (IRAN) (1), Southern Medical University [Guangzhou], Medical University of Plovdiv, Universitat Pompeu Fabra [Barcelona] (UPF), This study was supported by the ARC Foundation which funded OCAPOL study (A longitudinal observatory of the effects of chronic exposure to outdoor air pollution on cancer risk) within the framework of the CANC'AIR call (CANCAIR-201501234)., and Jonchère, Laurent
Subjects: Male, [SDE] Environmental Sciences, Skin Neoplasms, Environmental Engineering, Incidence, Parks, Recreational, Urbanity, Prostatic Neoplasms, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pollution, Nature, Cross-Sectional Studies, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Neoplasms, [SDE]Environmental Sciences, Prevalence, Humans, Environmental Chemistry, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Non-communicable diseases, Waste Management and Disposal, Natural environment
Abstract: International audience; We conducted a systematic review and meta-analysis of the available literature on the association between greenspace exposure and all-sites and site-specific cancer incidence, prevalence, and mortality in adults. We searched PubMed, Scopus, and Web of Science for original articles published, without language restriction until September 2021. We assessed the risk of bias in each study and the overall quality of evidence for exposure-outcome pairs that were reported in two or more studies. Out of the 18 included studies, cross-sectional studies were the most common study design (n = 8), and most of the studies were conducted in Europe (n = 8). In terms of risk of bias, the majority of cohorts (four out of six) and case-control studies (three out of four) were of good or very good quality, and cross-sectional studies were mostly (five out of eight) of poor quality. Outcomes (incidence, prevalence, mortality) on different cancer sites were reported: lung cancer (n = 9), prostate cancer (n = 4), breast cancer (n = 4), skin cancer (n = 3), colorectal cancer (n = 2), all-sites cancer (n = 2), brain cancer (n = 1), mouth and throat cancer (n = 1), and esophageal cancer (n = 1). The meta-analyses for the breast, lung, and prostate cancer incidence did not show statistically significant associations (for example for breast cancer: hazard ratio = 0.83; 95% confidence interval: 0.47-1.48). For skin cancer, the available evidence suggests that greenspace could be a potential risk factor. For the other cancers, the evidence was non-conclusive. The overall quality of evidence of all of the exposure-outcome pairs was very low. Given the wide confidence interval of the pooled estimates and very low quality of evidence, the findings should be interpreted with caution. Future large and longitudinal studies are needed to assess the potential association of greenspace exposure with cancers, considering types and quality of greenspace, evaluation of cancer sub-types, and adjustment for a sufficient set of covariates.
Published: 2022
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30. Long-term air pollution exposure, greenspace and health-related quality of life in the ECRHS study

Author: Anne, Boudier, Iana, Markevych, Bénédicte, Jacquemin, Michael J, Abramson, Simone, Accordini, Bertil, Forsberg, Elaine, Fuertes, Judith, Garcia-Aymerich, Joachim, Heinrich, Ane, Johannessen, Bénédicte, Leynaert, Isabelle, Pin, Valérie, Siroux, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), CHU Grenoble, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Monash university, Università degli studi di Verona = University of Verona (UNIVR), Umeå University, Imperial College London, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), Ludwig-Maximilians University [Munich] (LMU), University of Bergen (UiB), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier Universitaire [Grenoble] (CHU), The present analyses are part of the NEVADA project funded by the French Direction Générale de l'Offre de Soin (DGOS), call PHRC-2012.The local investigators and funding agencies for the European Community Respiratory Health Survey (ECRHS I, ECRHS II and ECRHS III) are reported in the online supplementary file.Coordination of the ECRHS I was supported by the European Commission as part of the 'Quality of Life' program and the authors and participants are grateful to the late C. Baya and M. Hallen for their help during the study and K. Vuylsteek and the members of the COMAC for their support. Coordination of the ECRHS II was supported by the European Commission as part of the 'Quality of Life' program (Grant: QLK4-CT-1999-01237). The coordination of the ECRHS 3 was funded through the Medical Research Council (Grant: 92091). NDVI calculations were conducted within the framework of the Ageing Lungs In European Cohorts study that was funded by the European Union's Horizon 2020 research and innovation program under (Grant: 633212). Iana Markevych is currently supported from the 'NeuroSmog: Determining the impact of air pollution on the developing brain' (Nr. POIR.04.04.00-1763/18-00) which is implemented as part of the TEAM-NET programme of the Foundation for Polish Science, co-financed from EU resources, obtained from the European Regional Development Fund under the Smart Growth Operational Programme. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019–2023' Program (CEX2018-000806-S), and the Generalitat de Catalunya through the CERCA Program., and Jonchère, Laurent
Subjects: Adult, Male, Environmental Engineering, greenness, PM, Epidemiology, Parks, Recreational, [SDV]Life Sciences [q-bio], Nitrogen Dioxide, Well-being, NO(2), NO2, rhinitis, well-being, Air Pollution, Humans, Environmental Chemistry, European Union, Waste Management and Disposal, Rhinitis, Air Pollutants, asthma, greenness, NO2, PM, well-being, Environmental Exposure, asthma, Health Surveys, Pollution, Asthma, [SDV] Life Sciences [q-bio], Greenness, Quality of Life, Female, Particulate Matter, epidemiology
Abstract: International audience; BACKGROUND: Associations of long-term exposure to air pollution and greenspace with health-related quality of life (HRQOL) are poorly studied and few studies have accounted for asthma-rhinitis status. OBJECTIVE: To assess the associations of air pollution and greenspace with HRQOL and whether asthma and/or rhinitis modify these associations. METHODS: The study was based on the participants in the second (2000-2002, n = 6542) and third (2011-2013, n = 3686) waves of the European Community Respiratory Health Survey (ECRHS) including 19 centres. The mean follow-up time was 11.3 years. HRQOL was assessed by the SF-36 Physical and Mental Component Summary scores (PCS and MCS). NO(2), PM(2.5) and PM(10) annual concentrations were estimated at the residential address from existing land-use regression models. Greenspace around the residential address was estimated by the (i) mean of the Normalized Difference Vegetation Index (NDVI) and by the (ii) presence of green spaces within a 300 m buffer. Associations of each exposure variable with PCS and MCS were assessed by mixed linear regression models, accounting for the multicentre design and repeated data, and adjusting for potential confounders. Analyses were stratified by asthma-rhinitis status. RESULTS: The mean (SD) age of the ECRHS-II and III participants was 43 (7.1) and 54 (7.2) years, respectively, and 48 % were men. Higher NO(2), PM(2.5) and PM(10) concentrations were associated with lower MCS (regression coefficients [95%CI] for one unit increase in the inter-quartile range of exposures were -0.69 [-1.23; -0.15], -1.79 [-2.88; -0.70], -1.80 [-2.98; -0.62] respectively). Higher NDVI and presence of forests were associated with higher MCS. No consistent associations were observed for PCS. Similar association patterns were observed regardless of asthma-rhinitis status. CONCLUSION: European adults who resided at places with higher air pollution and lower greenspace were more likely to have lower mental component of HRQOL. Asthma or rhinitis status did not modify these associations.
Published: 2022
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31. Rhinitis phenotypes and multimorbidities in the general population Constances cohort

Author: Marine Savouré, Jean Bousquet, Bénédicte Leynaert, Adeline Renuy, Valérie Siroux, Marcel Goldberg, Marie Zins, Bénédicte Jacquemin, Rachel Nadif, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin Institute of Health (BIH), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), L'Oreal USA, Caisse nationale d'assurance maladie, Merck Sharp and Dohme, Agence de l'Environnement et de la Maîtrise de l'Energie, AstraZeneca, Agence Nationale de la Recherche ANR-11-INBS-0002 Université Paris-Saclay, and ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011)
Subjects: Pulmonary and Respiratory Medicine, [SDV]Life Sciences [q-bio], [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract: BackgroundScarce epidemiological studies have characterised allergic rhinitis (AR) and non-allergic rhinitis (NAR) in adults. In a population-based cohort, our aims were to 1) describe rhinitis, AR and NAR, and 2) explore how asthma and conjunctivitis may lead to the identification of novel rhinitis phenotypes.MethodsIn this cross-sectional analysis, current rhinitis was defined as present in the last 12 months using a questionnaire from the French CONSTANCES cohort. Participants with current rhinitis reporting nasal allergies were considered as AR, otherwise as NAR. We described AR and NAR phenotypes, and their phenotypes including co-occurrence with ever-asthma and ever-conjunctivitis.ResultsAmong the 20 772 participants included in this analysis (mean±sdage 52.6±12.6 years; 55.2% female), crude prevalences of AR and NAR were 28.0% and 10.9%. AR participants more frequently reported persistent rhinitis (31.6%versus25.1%) and moderate-to-severe rhinitis (40.1%versus24.2%) than NAR participants. Among AR or NAR participants, those with ever-asthma reported more moderate-to-severe rhinitis. Participants with AR, ever-asthma and ever-conjunctivitis had an earlier age of rhinitis onset, more severe rhinitis and higher eosinophil counts than participants in other groups. Results were replicated in another cohort.ConclusionsIn this large population-based cohort, 40% reported current rhinitis, with a lower prevalence of moderate-to-severe rhinitis than in clinical practice. For the first time in a general adult population, we showed that AR and NAR alone or in combination with asthma or in combination with asthma and conjunctivitis are different phenotypes. These results provide new insights on how best to manage rhinitis and its multimorbidities.
Published: 2022
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32. Association between Outdoor Air Pollution Exposure and Handgrip Strength: Findings from the French CONSTANCES Study

Author: Mohammad Javad Zare Sakhvidi, Antoine Lafontaine, Jun Yang, Emeline Lequy, Fanny Artaud, Marianne Canonico, Anna Ozguler, Danielle Vienneau, Marie Zins, Bénédicte Jacquemin, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Institut Gustave Roussy (IGR), Mode de vie, génétique et santé : études intégratives et transgénérationnelles (U1018 (Équipe 9)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), This study was funded by the agence national de recherche (ANR, French National Research Agency) (ANR-17-CE36-0005) and by Fondation de France (Engt 00089829). The CONSTANCES Cohort Study is supported and funded by the CNAM. The CONSTANCES Cohort Study is an Infrastructure nationale en Biologie et Santé and beneﬁts from a grant from the ANR (ANR-11-INBS-0002) and from the Ministry of Research. CONSTANCES is also partly funded by Merck Sharp & Dohme (MSD), and l’Oréal., ANR-17-CE36-0005,PoCoMo,Étude des effets de la pollution atmosphérique sur les processus cognitifs dans la cohorte Constances(2017), Chard-Hutchinson, Xavier, and Étude des effets de la pollution atmosphérique sur les processus cognitifs dans la cohorte Constances - - PoCoMo2017 - ANR-17-CE36-0005 - AAPG2017 - VALID
Subjects: Air Pollutants, Hand Strength, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Health, Toxicology and Mutagenesis, Air Pollution, Air Pollution, Indoor, Public Health, Environmental and Occupational Health, Particulate Matter, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Environmental Exposure, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2022
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33. Greenspace exposure and children behavior: A systematic review

Author: Mohammad Javad Zare Sakhvidi, Pablo Knobel, Mariska Bauwelinck, Carmen de Keijzer, Lilian Marie Boll, Giuseppina Spano, Monica Ubalde-Lopez, Giovanni Sanesi, Amir Houshang Mehrparvar, Bénédicte Jacquemin, Payam Dadvand, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre de Ciència i Tecnologia Forestal de Catalunya (CTFC), Vrije Universiteit Brussel (VUB), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), CIBER de Epidemiología y Salud Pública (CIBERESP), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Yazd University, Chard-Hutchinson, Xavier, Faculty of Economic and Social Sciences and Solvay Business School, Sociology, and Interface Demography
Subjects: [SDE] Environmental Sciences, Parks, Recreational, [SDV]Life Sciences [q-bio], Neurodevelopmental disorders, Urbanization, Child Behavior, Environmental engineering, Pollution, Nature, Cohort Studies, [SDV] Life Sciences [q-bio], Attention Deficit Disorder with Hyperactivity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Surveys and Questionnaires, [SDE]Environmental Sciences, Humans, Environmental Chemistry, Psychology, Mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Waste Management and Disposal, Child development
Abstract: International audience; We systematically reviewed the existing evidence (until end of November 2021) on the association between long-term exposure to greenspace and behavioral problems in children according to the PRISMA 2020. The review finally reached 29 relevant studies of which, 17 were cross-sectional, 11 were cohort, and one was a case-control. Most of the studies were conducted in Europe (n = 14), followed by the USA (n = 8), and mainly (n = 21) from 2015 onwards. The overall quality of the studies in terms of risk of bias was "fair" (mean quality score = 5.4 out of 9) according to the Newcastle-Ottawa Scale. Thirteen studies (45%) had good or very good quality in terms of risk of bias. The strength and difficulty questionnaire was the most common outcome assessment instrument. Exposure to the greenspace in the reviewed studies was characterized based on different indices (availability, accessibility, and quality), mostly at residential address locations. Association of exposure to different types of greenspace were reported for nine different behavioral outcomes including total behavioral difficulties (n = 16), attention deficit hyperactivity disorder (ADHD) symptoms and severity (n = 15), ADHD diagnosis (n = 10), conduct problems (n = 10), prosocial behavior (n = 10), emotional symptoms (n = 8), peer-relationship problems (n = 8), externalizing disorders (n = 6), and internalizing disorders (n = 5). Most of the reported associations (except for conduct problems) were suggestive of beneficial association of greenspace exposure with children’s behaviors; however, the studies were heterogeneous in terms of their exposure indicators, study design, and the outcome definition.
Published: 2022
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34. Outdoor air pollution exposure and cognitive performance: findings from the enrolment phase of the CONSTANCES cohort

Author: Mohammad Javad Zare Sakhvidi, Jun Yang, Emeline Lequy, Jie Chen, Kees de Hoogh, Noémie Letellier, Marion Mortamais, Anna Ozguler, Danielle Vienneau, Marie Zins, Marcel Goldberg, Claudine Berr, Bénédicte Jacquemin, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Utrecht University [Utrecht], Swiss Tropical and Public Health Institute [Basel], Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), The Caisse Nationale d’Assurance Maladie, and partly funded by Merck Sharp and Dohme and L’Oréal, the French National Research Agency, and Fondation de France., and Chard-Hutchinson, Xavier
Subjects: Adult, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Health (social science), Adolescent, Health Policy, Public Health, Environmental and Occupational Health, Medicine (miscellaneous), [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Environmental Exposure, Middle Aged, Young Adult, Cognition, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Air Pollution, Humans, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Particulate Matter, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Aged
Abstract: Background Air pollution exposure is one of the modifiable risk factors of cognitive decline. We aimed to test the association between exposure to several outdoor air pollutants and domain-specific cognitive performance. Methods In this cross-sectional study, we used data from the enrolment phase of the French CONSTANCES cohort. From the 220 000 people (aged 18-69 years) randomly recruited in the French CONSTANCES cohort, participants aged 45 years old or older (104 733 people) underwent a comprehensive cognitive assessment (verbal episodic memory, language skills, and executive functions). After exclusion of those who were not suitable for our analysis, 61 462 participants with available data were included in the analyses. We used annual mean concentrations at residential addresses, derived from land-use regression models, to assign exposure to particulate matter with aerodynamic diameters less than 2·5 μm (PM2·5), nitrogen dioxide (NO2), and black carbon. We used multiple linear regression models with different covariate adjustments to test the associations between each pollutant and cognitive outcomes. We did several sensitivity analyses, including multilevel modelling, meta-analysis by centre of recruitment, and exclusion of specific population groups. Findings We found significantly poorer cognitive function, especially on semantic fluency and domains of executive functions, with an increase in exposure to black carbon and NO2. Exposure to PM2·5 was mainly significant for the semantic fluency test. We found that decrease in cognitive performance with an increase of one interquartile range of exposure ranged from 1% to nearly 5%. The largest effect size (percentage decrease) for both PM2.5 and NO2 was found for the semantic fluency test (PM2.5 4·6%, 95% CI 2·1-6·9 and NO2 3·8%, 1·9-5·7), whereas for black carbon, the largest effect size was found for the digit symbol substitution test of the domains of executive functions (4·5%, 2·7-6·3). Monotonic and linear exposure-response associations were found between air pollution exposure and cognitive performance, starting from a low level of exposures. Interpretation Significantly poorer cognitive performance was associated with exposure to outdoor air pollution even at low levels of exposure. This highlights the importance of further efforts to reduce exposure to air pollution. Funding The Caisse Nationale d'Assurance Maladie, and partly funded by Merck Sharp & Dohme and L'Oréal, the French National Research Agency, and Fondation de France. Translation For the French translation of the abstract see Supplementary Materials section.
Published: 2022
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35. Long-term air pollution exposure, greenness and health-related quality of life (HRQOL) in ECRHS

Author: Bénédicte Jacquemin, Bénédicte Leynaert, Joachim Heinrich, Elaine Fuertes, Anne Boudier, Iana Markevych, Michael J. Abramson, Ane Johanessen, Judith Garcia-Aymerich, Isabelle Pin, Valérie Siroux, Simone Accordini, Bertil Forsberg, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Monash University [Melbourne], Università degli studi di Verona = University of Verona (UNIVR), Umeå University, Imperial College London, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Helmholtz Zentrum München = German Research Center for Environmental Health, University of Bergen (UiB), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, and Centre Hospitalier Universitaire [Grenoble] (CHU)
Subjects: Quality of life, Health related quality of life, business.industry, [SDV]Life Sciences [q-bio], Environmental health, Air pollution exposure, Medicine, Environment, business, ComputingMilieux_MISCELLANEOUS, Asthma, Term (time)
Abstract: International audience
Published: 2021
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36. Exposure to airborne cadmium and lead and cognitive function in an adult population in rural France

Author: Jun Yang, Marie Zins, Claudine Berr, Noemie Letellier, Bénédicte Jacquemin, Antoine Lafontaine, Emeline Lequy, Sébastien Leblond, Mohammad Javad Zare Sakhvidi, Marcel Goldberg, and Caroline Meyer
Subjects: Cadmium, Lead (geology), chemistry, business.industry, Environmental health, Adult population, General Earth and Planetary Sciences, Medicine, chemistry.chemical_element, Cognition, business, General Environmental Science
Published: 2021
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37. Long-term exposure to air pollution and incidence of rhinitis in adults in the French population-based cohort Constances

Author: Marie Zins, Bénédicte Jacquemin, Kees de Hoogh, Marine Savouré, Emeline Lequy, Jean Bousquet, Rachel Nadif, Jie Chen, Marcel Goldberg, and Danielle Vienneau
Subjects: Population based cohort, business.industry, Incidence (epidemiology), Environmental health, Air pollution, General Earth and Planetary Sciences, Medicine, business, medicine.disease_cause, General Environmental Science, Term (time)
Published: 2021
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38. Association between air pollution exposure and handgrip strength as a marker of frailty: findings from the French CONSTANCES cohort

Author: Danielle Vienneau, Jun Yang, Marcel Goldberg, Bénédicte Jacquemin, Marianne Canonico, Fanny Artaud, Marie Zins, Claudine Berr, Mohammad Javad Zare Sakhvidi, Alexis Elbaz, Emeline Lequy, Jie Chen, Kees de Hoogh, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Utrecht University [Utrecht], Swiss Tropical and Public Health Institute [Basel], and International Society for Environmental Epidemiology
Subjects: Frailty, Particulate matters, business.industry, Air pollution exposure, Air pollution, medicine.disease_cause, CONSTANCES Cohort, Handgrip strength, Human health, Black carbon, Environmental health, Cohort, General Earth and Planetary Sciences, Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, General Environmental Science, Nitrogen dioxide
Abstract: International audience; BACKGROUND AND AIM - Air pollution exposure negatively affects human health and might also be linked to frailty. We aimed to evaluate whether exposure to air pollution is associated with poorer handgrip strength, a marker of frailty. METHODS - Data from the enrollment phase of the French CONSTANCES cohort participants aged 45-years and more were analyzed cross-sectionally. Modeled concentrations of PM2.5, black carbon, and NO2 from the ELAPSE land-use regression model were assigned to the residential address of each participant. Sex-specific maximum handgrip strength (HGSmax) was used as an outcome in multilevel linear regression models adjusted for a set of confounders (reported as β and 95% confidence interval (CI)), using the center of recruitment as a clustering factor. Subgroup analyses were performed across different levels of urbanicity and different personal variables including clinical risk factors. RESULTS - Of the 53,379 participants (mean age 57.4±7.2 years), 50.3% were women. The median concentration of PM2.5, black carbon, and NO2 was 16.1 (IQR=3.8) µg/m3, 1.6 (IQR=0.7) 10-5/m, and 22.5 (IQR=13.7) µg/m3, respectively. HGSmax in men was significantly higher than in women (42.1 vs. 25.6 kg). Exposure to all the three pollutants was associated with lower HGSmax in both sexes (e.g. β= -0.08; 95% CI: -0.11: -0.04 in men, and β= -0.08; 95% CI: -0.12: -0.04 in women per 3.8 µg/m3 exposure to PM2.5 in the adjusted model). Significantly stronger associations were found for all three pollutants (in single pollutant models) in men aged 65 years and older compared to younger men. Men with diabetes, depression, and cardiovascular disease tended to have poorer HGSmax associated with exposure to all of the pollutants. Stratified results for women were less conclusive. CONCLUSIONS - In this large general population study, air pollution was associated with poorer HGS, especially in men. It is of importance because HGS is a marker of general well-being and frailty.
Published: 2021
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39. Air pollution exposure and different dimensions of depression: findings from the French CONSTANCES cohort

Author: Marcel Goldberg, Emeline Lequy, Marie Zins, Bénédicte Jacquemin, Jie Chen, Claudine Berr, Mohammad Javad Zare Sakhvidi, Cédricberr Lemogne, Jun Yang, Danielle Vienneau, Kees de Hoogh, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Utrecht University [Utrecht], Swiss Tropical and Public Health Institute [Basel], Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), and International Society for Environmental Epidemiology (ISEE)
Subjects: Particulate matters, business.industry, Air pollution exposure, Depressive symptoms, CONSTANCES Cohort, Black carbon, Environmental health, Cohort, General Earth and Planetary Sciences, Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Depression (differential diagnoses), Nitrogen dioxide, General Environmental Science
Abstract: International audience; BACKGROUND AND AIM - The evidence for the association between air pollution exposure and depression is growing. We aim to explore this association across different dimensions of depressive symptoms. METHODS - Data from the enrollment phase of the French CONSTANCES cohort were analyzed cross-sectionally. Annual concentrations of PM2.5, black carbon (BC), and Nitrogen dioxide (NO2) from the ELAPSE land-use regression models were assigned at the residential addresses of participants. The z-score of depressive symptoms measured by the Centre of Epidemiologic Studies Depression (CES-D) questionnaire, and its four dimensions (depressive affect, interpersonal relations, low positive affect, somatic complaints) were used as outcomes in multiple linear regression models (reported as β and 95% confidence interval (CI) for an interquartile range (IQR) increase in exposure), for each pollutant separately. Stratified analyses were performed by sex, income, family status, education and community-level deprivation index. RESULTS - Of the 116,170 included participants (mean age: 46.4±13.6 years), 53.2% were women. The median exposure to PM2.5, BC and NO2 was 14.4 µg/m3 (IQR=4.4), 1.4 10-5/m (IQR=0.8), and 19.8 µg/m3 (IQR=15.3), respectively. The prevalence of depressive symptoms in women was higher than in men (27.7% vs. 17.0%). Exposure to BC and NO2 were significantly associated with higher total CES-D and all dimensions scores. PM2.5 was associated with depressive affect only (β= 0.03; 95% CI=0.01: 0.04). For all models and pollutants, the largest estimate was observed for the depressive affect. We found stronger associations for men, lower-income participants, low education groups, and those living alone. CONCLUSIONS - Air pollution exposure was associated with all dimensions of depressive symptoms and not only somatic complaints. Considering the burden related to depression, its prevalence, and the increasing trend of urbanization which is associated with higher exposure to pollutants, our findings are of utmost importance.
Published: 2021
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40. Questionnaire as an alternative of skin prick tests to differentiate allergic from non-allergic rhinitis in epidemiological studies

Author: Isabelle Pin, Laurent Orsi, Jean Bousquet, Valérie Siroux, Bénédicte Jacquemin, Marine Savouré, Rachel Nadif, Emilie Burte, Jocelyne Just, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Merck Sharp and Dohme, Agence de l'Environnement et de la Maîtrise de l'Energie, and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: medicine.medical_specialty, Non-allergic rhinitis, [SDV]Life Sciences [q-bio], Immunology, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Epidemiology, medicine, Hypersensitivity, Immunology and Allergy, Humans, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Rhinitis, Skin Tests, 0303 health sciences, business.industry, Allergens, medicine.disease, Dermatology, Rhinitis, Allergic, 3. Good health, Epidemiologic Studies, 030228 respiratory system, business
Abstract: National audience
Published: 2021
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41. Greenspace exposure and cancer incidence: A 27-year follow-up of the French GAZEL cohort

Author: Emeline Lequy, Marie Zins, Danielle Vienneau, Bénédicte Jacquemin, Marcel Goldberg, Mohammad Javad Zare Sakhvidi, Payam Dadvand, Jun Yang, Kees de Hoogh, Jack Siemiatycki, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Swiss Tropical and Public Health Institute [Basel], Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Université de Paris (UP), This study was supported by the ARC Foundation which funded OCAPOL study (A longitudinal observatory of the effects of chronic exposure to outdoor air pollution on cancer risk) within the framework of the CANC'AIR call. Payam Dadvand is funded by a Ramón y Cajal fellowship (RYC-201210995) awarded by the Spanish Ministry of Economy and Competitiveness., Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université Paris Cité (UPCité), and Chard-Hutchinson, Xavier
Subjects: Male, Longitudinal study, Environmental Engineering, 010504 meteorology & atmospheric sciences, Parks, Recreational, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, 010501 environmental sciences, 01 natural sciences, Cohort Studies, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, Neoplasms, medicine, Humans, Environmental Chemistry, Waste Management and Disposal, 0105 earth and related environmental sciences, 2. Zero hunger, Proportional hazards model, business.industry, Incidence, Hazard ratio, Cancer, medicine.disease, Pollution, [SDE.ES]Environmental Sciences/Environmental and Society, 3. Good health, [SDV] Life Sciences [q-bio], Greenspace, Environmental health, Cancer incidence, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cohort, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, [SDE.ES] Environmental Sciences/Environmental and Society, Skin cancer, business, Follow-Up Studies, Demography
Abstract: International audience; BACKGROUND: Greenspace exposure has been suggested to be associated with a range of health outcomes. The available evidence on the association of this exposure with cancer is still very scarce and inconsistent. OBJECTIVES: We aimed to study the association between greenspace exposure and all-site and site-specific (prostate, breast, colorectal, bladder, lung, and malignant melanoma of skin) cancer incidence in the GAZEL cohort. METHODS: This study was based on over 27 years of follow-up (1989-2016) of 19,408 participants across France. We assessed the residential greenspace exposure within several buffers as well as residential proximity to green spaces (agricultural, urban, and forests) in each follow-up. We used time-dependent Cox models, controlling for time-varying personal and area-level variables, with different lags between exposure and outcome. Additional analysis was conducted according to the urban-rural residence of the participants’ over follow-up. RESULTS: Over the 294,645 person-years of follow-up, we registered 4075 incident cases of cancer. We found an increase in the risk for all-sites cancer with an inter-quartile range increase of Normalized Difference in Vegetation Index across different buffers (hazard ratio (HR) of 1.08; 95% CI: 1.02, 1.14 for the 100 m buffer). We found a positive association of all-sites cancer with proximity to agricultural lands (HR: 1.03; 95% CI: 1.00, 1.05), and forests (HR:1.04; 95% CI: 1.00, 1.07), but not with urban green spaces. The cancer site-specific analyses suggested a protective role of greenspace for breast, lung, and colorectal cancers (e.g. breast cancer HR at 100 m buffer: 0.82; 95% CI: 0.69, 0.99). Non-significant associations were observed for prostate, bladder, and skin cancer. Stratified analyses based on urban, semi-urban, and rural classification did not suggest any differential pattern. CONCLUSION: We identified an increased risk of all-site cancer with increased greenspace and proximity to agricultural lands and forests; whereas potential protective role of greenspace for breast cancer.
Published: 2021
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42. Contribution of Long-Term Exposure to Outdoor Black Carbon to the Carcinogenicity of Air Pollution: Evidence regarding Risk of Cancer in the Gazel Cohort

Author: Kees de Hoogh, Jean-François Dupuy, Jack Siemiatycki, Valérie Garès, Bénédicte Jacquemin, Ole Hertel, Danielle Vienneau, Emeline Lequy, Marcel Goldberg, Jesper H. Christensen, Marie Zins, Sergey Zhivin, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Swiss Tropical and Public Health Institute [Basel], Institut de Recherche Mathématique de Rennes (IRMAR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Aarhus University [Aarhus], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), ARC Foundation (OCAPOL, CANCAIR-201501234), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and HAL UR1, Admin
Subjects: Adult, Fine particulate, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Air pollution, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Air Pollution, Neoplasms, medicine, Aerodynamic diameter, Humans, 030212 general & internal medicine, Carcinogen, 0105 earth and related environmental sciences, Air Pollutants, Research, Public Health, Environmental and Occupational Health, Carbon black, Environmental Exposure, Carbon, 3. Good health, [SDV] Life Sciences [q-bio], 13. Climate action, Cohort, Environmental science, Particulate Matter
Abstract: BACKGROUND: Black carbon (BC), a component of fine particulate matter [particles with an aerodynamic diameter ≤2:5 lm (PM2:5)], may contribute to carcinogenic effects of air pollution. Until recently however, there has been little evidence to evaluate this hypothesis. OBJECTIVE: This study aimed to estimate the associations between long-term exposure to BC and risk of cancer. This study was conducted within the French Gazel cohort of 20,625 subjects. METHODS: We assessed exposure to BC by linking subjects’ histories of residential addresses to a map of European black carbon levels in 2010 with back-and forward-extrapolation between 1989 and 2015. We used extended Cox models, with attained age as time-scale and time-varying cumulative exposure to BC, adjusted for relevant sociodemographic and lifestyle variables. To consider latency between exposure and cancer diagnosis, we implemented a 10-y lag, and as a sensitivity analysis, a lag of 2 y. To isolate the effect of BC from that of total PM2:5, we regressed BC on PM2:5 and used the residuals as the exposure variable. RESULTS: During the 26-y follow-up period, there were 3,711 incident cancer cases (all sites combined) and 349 incident lung cancers. Median base-line exposure in 1989 was 2.65 10−5 /m [interquartile range (IQR): 2.23–3.33], which generally slightly decreased over time. Using 10 y as a lag-time in our models, the adjusted hazard ratio per each IQR increase of the natural log-transformed cumulative BC was 1.17 (95% confidence interval: 1.06, 1.29) for all-sites cancer combined and 1.31 (0.93, 1.83) for lung cancer. Associations with BC residuals were also positive for both outcomes. Using 2 y as a lag-time, the results were similar. DISCUSSION: Our findings for a cohort of French adults suggest that BC may partly explain the association between PM2:5 and lung cancer. Additional studies are needed to confirm our results and further disentangle the effects of BC, total PM2:5, and other constituents. https://doi.org/10.1289/EHP8719.
Published: 2021
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43. The effect of short term exposure to outdoor air pollution on fertility

Author: Mark J. Nieuwenhuijsen, Tom Cole-Hunter, Bénédicte Jacquemin, Mireia González-Comadran, Rafael Lafuente, Miguel A. Checa, Marta Cirach, Mario Brassesco, Buenaventura Coroleu, IMIM-Hospital del Mar, Generalitat de Catalunya, École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CIBER de Epidemiología y Salud Pública (CIBERESP), University of Copenhagen = Københavns Universitet (KU), Instituto de Salud Carlos IIIInstituto de Salud Carlos IIIEuropean Commission [PI13/00454], AGAUR (Agency for Management of University and Research Grants, Generalitat de Catalunya), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and University of Copenhagen = Københavns Universitet (UCPH)
Subjects: Male, Time Factors, QH471-489, PM, [SDV]Life Sciences [q-bio], Air pollution, medicine.disease_cause, NO2, Miscarriage, Cohort Studies, 0302 clinical medicine, Endocrinology, Risk Factors, Pregnancy, 030212 general & internal medicine, Prospective cohort study, media_common, Nitrogen dioxide, ASSOCIATIONS, RISK, Air Pollutants, 030219 obstetrics & reproductive medicine, Obstetrics, Reproduction, Pregnancy Outcome, Obstetrics and Gynecology, Embryo transfer, Treatment Outcome, CARDIOVASCULAR-DISEASE, (2 5), Female, HEALTH, Infertility, Female, MAJOR ROADWAYS, Adult, medicine.medical_specialty, media_common.quotation_subject, EUROPEAN COHORTS, Reproductive medicine, Fertility, Fertilization in Vitro, PM2.5, ESCAPE, NO, PARTICULATE-MATTER, 03 medical and health sciences, PM10, LUNG-CANCER, Air Pollution, Acute exposure, medicine, Humans, business.industry, Research, Infant, Newborn, Environmental Exposure, Gynecology and obstetrics, medicine.disease, Abortion, Spontaneous, PHYSICAL-ACTIVITY, Reproductive Medicine, 13. Climate action, Spain, RG1-991, business, Particulate matter, Developmental Biology
Abstract: BackgroundThere is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable.MethodsThis prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM2.5[particulate matter (PM) ≤2.5 μm], PMcoarse(PM between 2.5 and 10μm), PM10(PM≤10 μm), PM2.5abs, and NO2and NOx. Outcomes were analyzed using multi-level regression models, with adjustment for co-pollutants and confouding factors. Two sensitivity analyses were performed. First, the model was adjusted for subacute exposure (received 15 days before ET). The second analysis was based on the first transfer performed on each patient aiming to exclude patients who failed previous transfers.ResultsOne hundred ninety-four women were recruited, contributing with data for 486 embryo transfers.Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM2.5exposure on 3D after adjusting for subacute exposure, and an increased risk of achieving no pregnancy for PM2.5, PMcoarseand PM10on 3D.The second sensitivity analysis showed a significant risk of miscarriage for PM2.5exposure on 3D, and a significant risk of achieving no pregnancy for PM2.5, PMcoarseand PM10 particularly on 3D. No association was observed for nitrogen dioxides on reproductive outcomes.ConclusionsExposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.
Published: 2021
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44. Assessing the impact of exposome on the course of chronic obstructive pulmonary disease and cystc fibrosis

Author: Manon Benjdir, Étienne Audureau, Ariel Beresniak, Patrice Coll, Ralph Epaud, Kristina Fiedler, Bénédicte Jacquemin, Laurent Niddam, Spyros N. Pandis, Gerhard Pohlmann, Torkjel M. Sandanger, Kai Simmons, Mette Sørensen, Patrick Wagner, Sophie Lanone
Published: 2021
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45. Assessing the impact of exposome on the course of chronic obstructive pulmonary disease and cystc fibrosis: The REMEDIA European Project Approach

Author: Laurent Niddam, Spyros N. Pandis, Ralph Epaud, Ariel Beresniak, Kai Simmons, Torkjel M Sandanger, Bénédicte Jacquemin, Sophie Lanone, Manon Benjdir, Patrice Coll, Patrick Wagner, Mette Sørensen, Etienne Audureau, Kristina Fiedler, Gerhard Pohlmann, IMRB - GEIC2O/'Genetic and Environmental Interactions in COPD, Cystic fibrosis and Other (rare) respiratory diseases' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - 'Biomechanics and Respiratory Apparatus' [Créteil] (U955 Inserm - UPEC), Data Mining International, Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), INSERM-TRANSFERT [Paris] (IT), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Wellspring Kft [Budapest, Hungary], Foundation for Research and Technology - Hellas (FORTH), Fraunhofer Institute for Toxicology and Experimental Medicine (Fraunhofer ITEM), Fraunhofer (Fraunhofer-Gesellschaft), The Arctic University of Norway [Tromsø, Norway] (UiT), Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Max-Planck-Gesellschaft, Roskilde University, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), The REMEDIA project has received funding from the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No 874753., Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), The Arctic University of Norway (UiT), Publica, and Chard-Hutchinson, Xavier
Subjects: [SDE] Environmental Sciences, Exposome, medicine.medical_specialty, Epidemiology, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Population, Context (language use), Environmental Sciences & Ecology, Disease, EXHALED BREATH CONDENSATE, Cystic fibrosis, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary approach, Medicine, education, Intensive care medicine, 030304 developmental biology, Public, Environmental & Occupational Health, Chronic ostructive pulmonary disease, 0303 health sciences, Global and Planetary Change, education.field_of_study, COPD, Science & Technology, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Pollution, 3. Good health, Biomarker (cell), [SDV] Life Sciences [q-bio], 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Causal inference, [SDE]Environmental Sciences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Life Sciences & Biomedicine, Environmental Sciences
Abstract: Because of the direct interaction of lungs with the environment, respiratory diseases are among the leading causes of environment-related deaths in the world. Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are two highly debilitating diseases that are of particular interest in the context of environmental studies; they both are characterized by a similar progressive loss of lung function with small bronchi alterations, and a high phenotypic variability of unknown origin, which prevents a good therapeutic efficacy. In the last years, there has been an evolution in the apprehension of the study of diseases going from a restricted "one exposure, one disease" approach to a broader concept with other associating factors, the exposome. The overall objective of the REMEDIA project is to extend the understanding of the contribution of the exposome to COPD and CF diseases. To achieve our aim, we will (1) exploit data from existing cohorts and population registries to create a unified global database gathering phenotype and exposome information; (2) develop a flexible individual sensor device combining environmental and biomarker toolkits; (3) use a versatile atmospheric simulation chamber to simulate the health effects of complex exposomes; (4) use machine learning supervised analyses and causal inference models to identify relevant risk factors; and (5) develop econometric and cost-effectiveness models to assess the costs, performance, and cost-effectiveness of a selection of prevention strategies. The results will be used to develop guidelines to better predict disease risks and constitute the elements of the REMEDIA toolbox. The multidisciplinary approach carried out by the REMEDIA European project should represent a major breakthrough in reducing the morbidity and mortality associated with COPD and CF diseases. ispartof: ENVIRONMENTAL EPIDEMIOLOGY vol:5 issue:4 ispartof: location:United States status: published
Published: 2021
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46. Modeling exposure to airborne metals using moss biomonitoring in cemeteries in two urban areas around Paris and Lyon in France

Author: Emeline Lequy, Caroline Meyer, Danielle Vienneau, Claudine Berr, Marcel Goldberg, Marie Zins, Sébastien Leblond, Kees de Hoogh, Bénédicte Jacquemin, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Patrimoine naturel (PatriNat), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Office français de la biodiversité (OFB), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), This study was funded by ANR (ANR-17-CE36-0005) and by Fondation de France (Engt 00089829). The Constances Cohort Study is supported and funded by the Caisse nationale d'assurance maladie (CNAM). The Constances Cohort Study is an 'Infrastructure nationale en Biologie et Santé' and benefits from a grant from ANR (ANR-11-INBS-0002) and from the Ministry of Research. Constances is also partly funded by MSD, and L’Oréal., ANR-17-CE36-0005,PoCoMo,Étude des effets de la pollution atmosphérique sur les processus cognitifs dans la cohorte Constances(2017), ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Institut des Neurosciences de Montpellier (INM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: Antimony, Air Pollutants, [SDV]Life Sciences [q-bio], Health, Toxicology and Mutagenesis, Air pollution, Bryophyta, General Medicine, Toxicology, Pollution, Land-use regression, Exposure surface, Lead, Metals, Metals, Heavy, [SDE]Environmental Sciences, Humans, Cemeteries, Concentration map, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Moss biomonitoring, Biological Monitoring, Environmental Monitoring, Cadmium
Abstract: International audience; Exposure of the general population to airborne metals remains poorly estimated despite the potential health risks. Passive moss biomonitoring can proxy air quality at fine resolution over large areas, mainly in rural areas. We adapted the technique to urban areas to develop fine concentration maps for several metals for Constances cohort’s participants. We sampled Grimmia pulvinata in 77 and 51 cemeteries within ∼50 km of Paris and Lyon city centers, respectively. We developed land-use regression models for 14 metals including cadmium, lead, and antimony; potential predictors included the amount of urban, agricultural, forest, and water around cemeteries, population density, altitude, and distance to major roads. We used both kriging with external drift and land use regression followed by residual kriging when necessary to derive concentration maps (500 × 500 m) for each metal and region. Both approaches led to similar results. The most frequent predictors were the amount of urban, agricultural, or forest areas. Depending on the metal, the models explained part of the spatial variability, from 6% for vanadium in Lyon to 84% for antimony in Paris, but mostly between 20% and 60%, with better results for metals emitted by human activities. Moss biomonitoring in cemeteries proves efficient for obtaining airborne metal exposures in urban areas for the most common metals.
Published: 2022
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47. Influence of exposure assessment methods on associations between long-term exposure to outdoor fine particulate matter and risk of cancer in the French cohort Gazel

Author: Emeline Lequy, Mohammad Javad Zare Sakhvidi, Danielle Vienneau, Kees de Hoogh, Jie Chen, Jean-François Dupuy, Valérie Garès, Emilie Burte, Olivier Bouaziz, Alain Le Tertre, Vérène Wagner, Ole Hertel, Jesper Heile Christensen, Sergey Zhivin, Jack Siemiatycki, Marcel Goldberg, Marie Zins, Bénédicte Jacquemin, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Swiss Tropical and Public Health Institute [Basel], Utrecht University [Utrecht], Institut de Recherche Mathématique de Rennes (IRMAR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Aarhus University [Aarhus], and The Gazel Cohort Study was funded by EDF-GDF, and received grants from CAMIEG (Caisse d'assurance maladie des industries électrique et gazière) and the 'Comité de coordination des CMCAS'. This study was supported by the ARC French Foundation for cancer research (OCAPOL, CANCAIR-201501234).
Subjects: Air Pollutants, Environmental Engineering, PM, Epidemiology, [SDV]Life Sciences [q-bio], PM(2.5), Air pollution, Environmental Exposure, Survival analysis, Pollution, Air Pollution, Neoplasms, [SDE]Environmental Sciences, Humans, Environmental Chemistry, Particulate Matter, Lung cancer, Waste Management and Disposal
Abstract: Background: Many studies investigated the relationship between outdoor fine particulate matter (PM2.5) and cancer. While they generally indicated positive associations, results have not been fully consistent, possibly because of the diversity of methods used to assess exposure. Objectives: To investigate how using different PM2.5 exposure assessment methods influences risk estimates in the large French general population-based Gazel cohort (20,625 participants at enrollment) with a 26-year follow-up with complete residential histories. Methods: We focused on two cancer incidence outcomes: all-sites combined and lung. We used two distinct exposure assessment methods: a western European land use regression (LUR), and a chemistry-dispersion model (Gazel-Air) for France, each with a time series ≥20-years annual concentrations. Spearman correlation coefficient between the two estimates of PM2.5 was 0.71 across all person-years; the LUR tended to provide higher exposures. We used extended Cox models with attained age as time-scale and time-dependent cumulative exposures, adjusting for a set of confounders including sex and smoking, to derive hazard ratios (HRs) and their 95% confidence interval, implementing a 10-year lag between exposure and incidence/censoring. Results: We obtained similar two-piece linear associations for all-sites cancer (3711 cases), with a first slope of HRs of 1.53 (1.24–1.88) and 1.43 (1.19–1.73) for one IQR increase of cumulative PM2.5 exposure for the LUR and the Gazel-Air models respectively, followed by a plateau at around 1.5 for both exposure assessments. For lung cancer (349 cases), the HRs from the two exposure models were less similar, with largely overlapping confidence limits. Conclusion: Our findings using long-term exposure estimates from two distinct exposure assessment methods corroborate the association between air pollution and cancer risk.
Published: 2022
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48. Long-term exposure to ambient air pollution and risk of dementia: results of the prospective Three-City study

Author: L. Gutierrrez, Tarik Benmarhnia, Noémie Letellier, Christophe Tzourio, Bénédicte Jacquemin, Claudine Berr, J. F. Dartigues, Marion Mortamais, K. de Hoogh, and Catherine Helmer
Subjects: Ozone, Ambient air pollution, medicine.disease, complex mixtures, chemistry.chemical_compound, chemistry, Air pollutants, Environmental chemistry, medicine, General Earth and Planetary Sciences, Dementia, Environmental science, Nitrogen dioxide, General Environmental Science
Abstract: BackgroundEmerging epidemiological evidence suggests a relationship between exposure to various air pollutants (AP) (fine particles (PM2.5), ozone (O3), nitrogen dioxide (NO2)) and dementia. Howeve...
Published: 2020
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49. Association between long-term exposure to outdoor black carbon and mortality in the French Gazel Cohort

Author: M. Sakhvidi, Danielle Vienneau, Emeline Lequy, Bénédicte Jacquemin, Marcel Goldberg, J. Yang, Jack Siemiatycki, K. de Hoogh, and Marie Zins
Subjects: business.industry, Cohort, General Earth and Planetary Sciences, Medicine, business, General Environmental Science, Term (time), Demography
Published: 2020
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50. Greenspace exposure and cancer incidence in the Gazel Cohort

Author: Emeline Lequy, P. Dadvand, Bénédicte Jacquemin, Marie Zins, M. Sakhvidi, Jack Siemiatycki, Marcel Goldberg, and J. Yang
Subjects: Cancer incidence, business.industry, Environmental health, Cohort, General Earth and Planetary Sciences, Medicine, business, General Environmental Science
Abstract: Background: Exposure to greenspace has been suggested to be associated with lower cancer incidence; however, the evidence is still very scarce, and controversial. Here, we reported the association ...
Published: 2020
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