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The effect of short term exposure to outdoor air pollution on fertility
- Source :
- Gonzalez-Comadran, M, Jacquemin, B, Cirach, M, Lafuente, R, Cole-Hunter, T, Nieuwenhuijsen, M, Brassesco, M, Coroleu, B & Angel Checa, M 2021, ' The effect of short term exposure to outdoor air pollution on fertility ', Reproductive Biology and Endocrinology, vol. 19, no. 1, 151 . https://doi.org/10.1186/s12958-021-00838-6, Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-9 (2021), Reproductive Biology and Endocrinology : RB&E, Reproductive Biology and Endocrinology, Reproductive Biology and Endocrinology, 2021, 19 (1), ⟨10.1186/s12958-021-00838-6⟩, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Publication Year :
- 2021
-
Abstract
- BackgroundThere is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable.MethodsThis prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM2.5[particulate matter (PM) ≤2.5 μm], PMcoarse(PM between 2.5 and 10μm), PM10(PM≤10 μm), PM2.5abs, and NO2and NOx. Outcomes were analyzed using multi-level regression models, with adjustment for co-pollutants and confouding factors. Two sensitivity analyses were performed. First, the model was adjusted for subacute exposure (received 15 days before ET). The second analysis was based on the first transfer performed on each patient aiming to exclude patients who failed previous transfers.ResultsOne hundred ninety-four women were recruited, contributing with data for 486 embryo transfers.Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM2.5exposure on 3D after adjusting for subacute exposure, and an increased risk of achieving no pregnancy for PM2.5, PMcoarseand PM10on 3D.The second sensitivity analysis showed a significant risk of miscarriage for PM2.5exposure on 3D, and a significant risk of achieving no pregnancy for PM2.5, PMcoarseand PM10 particularly on 3D. No association was observed for nitrogen dioxides on reproductive outcomes.ConclusionsExposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.
- Subjects :
- Male
Time Factors
QH471-489
PM
[SDV]Life Sciences [q-bio]
Air pollution
medicine.disease_cause
NO2
Miscarriage
Cohort Studies
0302 clinical medicine
Endocrinology
Risk Factors
Pregnancy
030212 general & internal medicine
Prospective cohort study
media_common
Nitrogen dioxide
ASSOCIATIONS
RISK
Air Pollutants
030219 obstetrics & reproductive medicine
Obstetrics
Reproduction
Pregnancy Outcome
Obstetrics and Gynecology
Embryo transfer
Treatment Outcome
CARDIOVASCULAR-DISEASE
(2 5)
Female
HEALTH
Infertility, Female
MAJOR ROADWAYS
Adult
medicine.medical_specialty
media_common.quotation_subject
EUROPEAN COHORTS
Reproductive medicine
Fertility
Fertilization in Vitro
PM2.5
ESCAPE
NO
PARTICULATE-MATTER
03 medical and health sciences
PM10
LUNG-CANCER
Air Pollution
Acute exposure
medicine
Humans
business.industry
Research
Infant, Newborn
Environmental Exposure
Gynecology and obstetrics
medicine.disease
Abortion, Spontaneous
PHYSICAL-ACTIVITY
Reproductive Medicine
13. Climate action
Spain
RG1-991
business
Particulate matter
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14777827
- Database :
- OpenAIRE
- Journal :
- Gonzalez-Comadran, M, Jacquemin, B, Cirach, M, Lafuente, R, Cole-Hunter, T, Nieuwenhuijsen, M, Brassesco, M, Coroleu, B & Angel Checa, M 2021, ' The effect of short term exposure to outdoor air pollution on fertility ', Reproductive Biology and Endocrinology, vol. 19, no. 1, 151 . https://doi.org/10.1186/s12958-021-00838-6, Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-9 (2021), Reproductive Biology and Endocrinology : RB&E, Reproductive Biology and Endocrinology, Reproductive Biology and Endocrinology, 2021, 19 (1), ⟨10.1186/s12958-021-00838-6⟩, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Accession number :
- edsair.doi.dedup.....3095b061bae6f6a3876398739d3e5e56