7 results on '"Azahara Martinez-Lopez"'
Search Results
2. Childhood florid follicular hyperplasia with immunoglobulin light-chain restriction in the gastrointestinal tract
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Juan Luis Afonso-Martin, Ana Batlle, Francisco Mazorra, Santiago Montes-Moreno, Sonia González de Villambrosia, Miguel A. Piris, Thomas M. Grogan, Rafael Ramos, Azahara Martinez-Lopez, and Universidad de Cantabria
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Male ,Pathology ,medicine.medical_specialty ,Histology ,Lymphoproliferative disorders ,Rectum ,Appendix ,Biology ,Immunoglobulin light chain ,Pathology and Forensic Medicine ,medicine ,Humans ,Overdiagnosis ,Child ,music ,In Situ Hybridization, Fluorescence ,B cell ,Gastrointestinal tract ,Hyperplasia ,music.instrument ,General Medicine ,medicine.disease ,Immunohistochemistry ,Follicular hyperplasia ,Lymphoproliferative Disorders ,medicine.anatomical_structure ,Child, Preschool ,Immunology ,biology.protein ,Female ,Immunoglobulin Light Chains ,Antibody ,Multiplex Polymerase Chain Reaction - Abstract
Aims Immunoglobulin light-chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders. Methods and results Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6 years). Immunohistochemical studies revealed lambda light-chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow-up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations. Conclusions Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light-chain restriction is not necessarily a marker of monoclonality.
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- 2014
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3. MYD88 (L265P) somatic mutation in marginal zone B-cell lymphoma
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Manuela Mollejo, Azahara Martinez-Lopez, Santiago Montes-Moreno, Carmen Almaraz, Nerea Martinez, Jose B. Revert, Miguel A. Piris, Laura Cereceda, and Soraya Curiel-Olmo
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Adult ,Male ,Paraproteinemia ,Pathology ,medicine.medical_specialty ,Polymerase Chain Reaction ,Pathology and Forensic Medicine ,Germline mutation ,medicine ,Biomarkers, Tumor ,Humans ,Splenic marginal zone lymphoma ,B cell ,Aged ,Aged, 80 and over ,business.industry ,Waldenstrom macroglobulinemia ,Lymphoma, B-Cell, Marginal Zone ,Middle Aged ,medicine.disease ,Lymphoma ,medicine.anatomical_structure ,Mutation (genetic algorithm) ,Mutation ,Myeloid Differentiation Factor 88 ,Surgery ,Marginal zone B-cell lymphoma ,Female ,Anatomy ,Waldenstrom Macroglobulinemia ,business - Abstract
MYD88 L265P is a somatic mutation that has been identified in about 90% of Waldenstrom macroglobulinemia/lymphoplasmacytic lymphomas (LPLs). It has also been detected in a subset of marginal zone lymphoma (MZL) cases, but the frequency and clinical and histologic features of these mutated MZL cases has only been partially characterized. We have developed a customized TaqMan allele-specific polymerase chain reaction for sensitive detection of this mutation in paraffin-embedded tissue. We analyzed samples from 19 patients with LPL, 88 patients with splenic marginal zone lymphoma (SMZL), 8 patients with nodal marginal zone lymphoma (NMZL), 21 patients with extranodal mucosa-associated lymphoid tissue (MALT), and 2 patients with B-cell lymphoma not otherwise specified. By integrating mutational, histologic, and clinical data, 5 cases were reclassified as LPL. After reclassification, MYD88 L265P was detected in 13/86 (15%) SMZL and in 19/24 LPL (79%) cases. The mutation was absent from NMZL and MALT cases. A strong correlation was found between the presence of an IgM monoclonal paraproteinemia and the MYD88 L265P mutation (P
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- 2015
4. Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma
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Karen Dybkær, Jiayu Chen, Youli Zu, Andrés J.M. Ferreri, Qi Shen, Ganiraju C. Manyam, Zijun Y. Xu-Monette, Kristy L. Richards, Santiago Montes-Moreno, Govind Bhagat, Alexandar Tzankov, Lan Pham, Jooryung Huh, Azahara Martinez-Lopez, John P. Farnen, Lihui Yin, J. Han van Krieken, Maurilio Ponzoni, Xiaoying Zhao, Lijuan Deng, Ken H. Young, William W.L. Choi, Miguel A. Piris, Carlo Visco, Eric D. Hsi, Michael Boe Møller, Attilio Orazi, April Chiu, Jane N. Winter, Li Zhang, and Universidad de Cantabria
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Male ,Lymphoma ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,Myc ,BCL2 ,CXCR4 ,DLBCL ,TP53 mutation ,Antibodies, Monoclonal, Murine-Derived ,Antineoplastic Combined Chemotherapy Protocols ,Cell Line, Tumor ,Cell Proliferation ,Cell Survival ,Chemokine CXCL12 ,Cyclophosphamide ,Disease Progression ,Doxorubicin ,Female ,Gene Expression Regulation, Neoplastic ,Germinal Center ,Humans ,Lymphoma, Large B-Cell, Diffuse ,Middle Aged ,Mutation ,Oligopeptides ,Prednisone ,Prognosis ,Receptors, CXCR4 ,Rituximab ,Transcriptome ,Tumor Suppressor Protein p53 ,Vincristine ,Chemokine receptor ,immune system diseases ,hemic and lymphatic diseases ,Monoclonal ,Receptors ,Tumor ,Diffuse ,3. Good health ,Oncology ,Research Paper ,Murine-Derived ,Biology ,Antibodies ,Cell Line ,medicine ,Large B-Cell ,neoplasms ,Tumor microenvironment ,Neoplastic ,Cell growth ,Germinal center ,medicine.disease ,Gene Expression Regulation ,Cancer research ,Germinal center B-cell like diffuse large B-cell lymphoma ,Diffuse large B-cell lymphoma - Abstract
Contains fulltext : 155086.pdf (Publisher’s version ) (Open Access) Abnormal expression of the chemokine receptor CXCR4 plays an essential role in tumor cell dissemination and disease progression. However, the significance of CXCR4 overexpression in de novo diffuse large B cell lymphoma (DLBCL) is unknown. In 743 patients with de novo diffuse large B cell lymphoma (DLBCL) who received standard Rituximab-CHOP immunochemotherapy, we assessed the expression of CXCR4 and dissected its prognostic significance in various DLBCL subsets. Our results showed that CXCR4+ patients was associated with male, bulky tumor, high Ki-67 index, activated B-cell-like (ABC) subtype, and Myc, Bcl-2 or p53 overexpression. Moreover, CXCR4+ was an independent factor predicting poorer progression-free survival in germinal-center B-cell-like (GCB)-DLBCL, but not in ABC-DLBCL; and in patients with an IPI of 2. The lack of prognostic significance of CXCR4 in ABC-DLBCL was likely due to the activation of p53 tumor suppressor attenuating CXCR4 signaling. Furthermore, concurrent CXCR4+ and BCL2 translocation showed dismal outcomes resembling but independent of MYC/BCL2 double-hit DLBCL. Gene expression profiling suggested that alterations in the tumor microenvironment and immune responses, increased tumor proliferation and survival, and the dissemination of CXCR4+ tumor cells to distant organs or tissues were underlying molecular mechanisms responsible for the CXCR4+ associated poor prognosis.
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- 2015
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5. Persistent polyclonal B-cell lymphocytosis with splenomegaly: histologic description of 2 cases
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Montse Fernandez-Alvarez, Jose Miguel Bosch, Juan Luis Alfonso Martin, Cesar Miranda-Vallina, Miguel A. Piris, Francisco Mazorra, Carlos Ulibarrena, Ana Burdaspal, Azahara Martinez-Lopez, Santiago Montes-Moreno, Valeria Peri, and Lidia Sanchez-Verde
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White pulp ,Adult ,Pathology ,medicine.medical_specialty ,Lymphocytosis ,medicine.medical_treatment ,Splenectomy ,Antigens, CD19 ,Spleen ,Pathology and Forensic Medicine ,medicine ,Humans ,Lymphocyte Count ,Lymphocytes ,biology ,business.industry ,Middle Aged ,medicine.disease ,Clone Cells ,medicine.anatomical_structure ,Immunoglobulin M ,Polyclonal antibodies ,Immunology ,Splenomegaly ,Red pulp ,biology.protein ,Surgery ,Female ,Anatomy ,medicine.symptom ,business ,Infiltration (medical) - Abstract
Persistent polyclonal B-cell lymphocytosis is a rare, benign lymphoproliferative disorder characterized by a stable, polyclonal CD19-positive CD5-negative lymphocytosis, the presence of binucleated lymphocytes in peripheral blood, and a polyclonal increase in serum immunoglobulin-M that may occasionally be accompanied by splenomegaly. Histopathologic diagnosis of these splenectomy specimens is difficult because of the massive spleen infiltration and the rarity of the descriptions of this condition. We describe the histopathologic findings from 2 splenectomy specimens. These included a partially preserved architecture with infiltration of the red pulp by small lymphocytes and partial replacement of the white pulp. Suggestions for identifying the disorder are made.
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- 2013
6. SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms
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Santiago Montes-Moreno, Shirley Quintana-Truyenque, Rocío Ramos-Medina, Azahara Martinez-Lopez, Jorge L. Martínez-Torrecuadrada, Miguel A. Piris, Raquel Pajares, Carlos Barrionuevo Cornejo, Alejandro Parra Cubillos, Socorro María Rodríguez Pinilla, Giovanna Roncador, and Lydia Sanchez-Verde
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Pathology ,medicine.medical_specialty ,Lymphoma ,medicine.drug_class ,Lymphoid Tissue ,Immunology ,Plasmacytoid dendritic cell ,Biology ,Monoclonal antibody ,Biochemistry ,Cell Line, Tumor ,medicine ,Biomarkers, Tumor ,Humans ,Progenitor cell ,ETS transcription factor family ,Cell Biology ,Hematology ,Dendritic Cells ,medicine.disease ,DNA-Binding Proteins ,stomatognathic diseases ,Hematologic Neoplasms ,Immunohistochemistry ,Interleukin-3 receptor ,Transcription Factors - Abstract
SPIB is an Ets transcription factor that is expressed exclusively in mature B cells, T-cell progenitors, and plasmacytoid dendritic cells. In the present study, we developed a novel mAb against the SPIB protein and characterized its expression in major hematolymphoid neoplasms, including a series of 45 cases of blastic plasmacytoid dendritic cell (BPDC) neoplasms and their potential cutaneous mimics. We found that SPIB is expressed heterogeneously among B- and T-cell lymphoma types. Interestingly, SPIB is expressed in a large proportion of nongerminal center type DLBCLs. In cutaneous neoplasms, SPIB is overexpressed in all BPDC neoplasms, but none of its cutaneous mimics. SPIB remains overexpressed in all cases that lack 1 or 2 of the markers used for BPDC neoplasms (ie, CD4, CD56, TCL1, and CD123). We conclude that SPIB expression can be used as a tool for diagnosing BPDC neoplasms, but it needs to be tested in conjunction with the growing arsenal of markers for human plasmacytoid dendritic cells.
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- 2012
7. Clinical and diagnostic relevance of NOTCH2-and KLF2-mutations in splenic marginal zone lymphoma
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Yolanda Campos-Martín, Nerea Martínez, Azahara Martínez-López, Laura Cereceda, Felipe Casado, Patrocinio Algara, David Oscier, Francisco J. Menarguez, Juan F. García, Miguel A Piris, and Manuela Mollejo
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2017
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