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Childhood florid follicular hyperplasia with immunoglobulin light-chain restriction in the gastrointestinal tract

Authors :
Juan Luis Afonso-Martin
Ana Batlle
Francisco Mazorra
Santiago Montes-Moreno
Sonia González de Villambrosia
Miguel A. Piris
Thomas M. Grogan
Rafael Ramos
Azahara Martinez-Lopez
Universidad de Cantabria
Source :
Histopathology Volume 65, Issue 6, 2014 Pages 805–813, UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC)
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

Aims Immunoglobulin light-chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders. Methods and results Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6 years). Immunohistochemical studies revealed lambda light-chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow-up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations. Conclusions Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light-chain restriction is not necessarily a marker of monoclonality.

Details

ISSN :
03090167
Volume :
65
Database :
OpenAIRE
Journal :
Histopathology
Accession number :
edsair.doi.dedup.....77b1789227c19c6f774cf35acc9e5b13
Full Text :
https://doi.org/10.1111/his.12511