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Childhood florid follicular hyperplasia with immunoglobulin light-chain restriction in the gastrointestinal tract
- Source :
- Histopathology Volume 65, Issue 6, 2014 Pages 805–813, UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC)
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Aims Immunoglobulin light-chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders. Methods and results Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6 years). Immunohistochemical studies revealed lambda light-chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow-up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations. Conclusions Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light-chain restriction is not necessarily a marker of monoclonality.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Histology
Lymphoproliferative disorders
Rectum
Appendix
Biology
Immunoglobulin light chain
Pathology and Forensic Medicine
medicine
Humans
Overdiagnosis
Child
music
In Situ Hybridization, Fluorescence
B cell
Gastrointestinal tract
Hyperplasia
music.instrument
General Medicine
medicine.disease
Immunohistochemistry
Follicular hyperplasia
Lymphoproliferative Disorders
medicine.anatomical_structure
Child, Preschool
Immunology
biology.protein
Female
Immunoglobulin Light Chains
Antibody
Multiplex Polymerase Chain Reaction
Subjects
Details
- ISSN :
- 03090167
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Histopathology
- Accession number :
- edsair.doi.dedup.....77b1789227c19c6f774cf35acc9e5b13
- Full Text :
- https://doi.org/10.1111/his.12511