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Lipoma can arise in any portion in the body where fat tissue is exist. However, lipoma in the oral cavity is rare and reported to occur only in 2-5% of benign tumor in the oral cavity in Japan. We treated a 66-year-old female with a lipoma of the tongue. Oral examination revealed a 27×23mm mass on the left edge of the tongue. The mass was firm on palpation. A T1 weighted axial MR image clearly showed a hyperintense mass with a small area of isointensity. The tumor was excised under general anesthesia. It was encapsulated and measured 50×30×25mm in size. The histopathologic diagnosis was lipoma with muscle components. A review of the Japanese literature showed 55 cases of lipoma of the tongue.

We report a case of hemangioma patient with phlebolith in the masseter.A 10-year-old girl exhibiting buccal swelling when biting consulted our hospital. The protrusion was mobile and when the patient was asked to bite strongly, an elastic soft tumor with slight swelling was detected.Magnetic resonance imaging (MRI) and echography suggested angioma in the masseter. The tumor was excised by external incision.Pathologically, it was diagnosed as cavernous hemangioma. In the lesion, two phleboliths were detected. We report this case and the treatment with reference to the literature.

Hypopharynx hemangioma is a rare disease. We reported a case of a 63-year-old woman who complained of laryngeal discomfort of nine months. Fiberscopy demonstrated a tumor with dark red, regular smooth surface that was located at the left piriform sinus.The tumor was completely excised by Holmium YAG laser. Histological examination revealed that it was a cavernous hemangioma.Recurrence of the tumor has not been observed in the three months since the surgery. The authors considered the effectiveness of the Holmium YAG laser in this case.

GATA factors comprise a small family of transcription regulatory proteins containing two conserved zinc finger DNA binding domains for the consensus sequence (WGATAR). Among the six GATA factors, GATA-1/2/3 factors are prominently expressed in the hematopoietic cell lineage, while GATA-4/5/6 factors show a partly overlapping expression pattern in the heart and endoderm-derived organs. We previously reported that GATA4 and GATA5 were silenced by their promoter hypermethylation in gastrointestinal, lung and ovarian cancers. However, it remains unknown the mechanism underlying loss of GATA transcription factors in gastric carcinogenesis. To clarify the role of GATA, we examined GATA4/5 methylation and their downstream target genes in gastric cancer (GC). By using methylation specific PCR, the methylation frequency of GATA5 (30, 39%) was significantly higher than that of GATA4 (10, 13%) in 77 GC tissues (P Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 200.