34 results on '"Arun C. Nachiappan"'
Search Results
2. Management Strategies for Patients Presenting With Symptomatic Lymphadenopathy and Breast Edema After Recent COVID-19 Vaccination
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Meng, Hao, Christine E, Edmonds, Arun C, Nachiappan, Emily F, Conant, and Samantha P, Zuckerman
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COVID-19 Vaccines ,SARS-CoV-2 ,Vaccination ,COVID-19 ,Edema ,Humans ,Lymphadenopathy ,Breast Neoplasms ,Female ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Early Detection of Cancer ,Mammography - Abstract
Ipsilateral axillary lymphadenopathy is a well-documented finding associated with COVID-19 vaccination. Varying guidelines have been published for the management of asymptomatic patients who have a history of recent vaccination and present with incidental lymphadenopathy at screening mammography. Some experts recommend follow-up imaging, and others suggest that clinical management, rather than repeat imaging or biopsy, is appropriate. Symptomatic patients with lymphadenopathy and/or additional abnormal imaging findings should be treated differently depending on risk factors and clinical scenarios. Although ipsilateral lymphadenopathy is well documented, ipsilateral breast edema after COVID-19 vaccination has been rarely reported. The combination of ipsilateral lymphadenopathy and diffuse breast edema after COVID-19 vaccination presents a clinical management challenge because edema can obscure underlying abnormalities at imaging. For symptomatic patients with lymphadenopathy and associated breast parenchymal abnormality, prompt action is appropriate, including diagnostic evaluation and consideration of tissue sampling. This approach may prevent delays in diagnosis and treatment of patients with malignancy masked by symptoms from the vaccination.
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- 2022
3. Comparative Evaluation of Choose Your Own Adventure and Traditional Linear Case Formats in Radiology Small Group Teaching
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Sarah P. Thomas, Ramie Fathy, Savannah Aepli, Caitlin B. Clancy, Gregg Y. Lipschik, Scott A. Simpson, Sharyn I. Katz, Robert W. Doms, and Arun C. Nachiappan
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Radiography ,Students, Medical ,Surveys and Questionnaires ,Teaching ,Humans ,Learning ,Radiology, Nuclear Medicine and imaging ,Radiology - Abstract
We aim to compare Choose Your Own Adventure (CYOA) presentation format with linear case format as educational methods for teaching a radiology small group session to medical students.A radiology small group session was held for preclinical second-year medical students in the pulmonary course, whereby eight classrooms of students and eight radiology facilitators were each randomized to do either the linear case format or the nonlinear CYOA presentation format. All students in attendance were administered a survey at the end of the session, which assessed students' perceptions using five-point Likert-type questions. The survey also contained a four-question knowledge quiz on chest radiology. The facilitators were administered a qualitative survey as well. Between-group analyses were performed using Student's t-test.Of the 144 students who attended the small group sessions, 143 students completed the survey (99.3%). The CYOA format group reported significantly greater engagement in the cases (4.5 ± 0.7 vs. 3.8 ± 0.7, p0.001), satisfaction with the format (4.6 ± 0.6 vs. 3.7 ± 0.9, p0.001), and enhancement of clinical decision making skills (4.5 ± 0.6 vs. 3.5 ± 0.9, p0.001). The linear format group reported a greater role for the facilitator to add value (4.6 ± 0.5 vs. 4.3 ± 1.1, p = 0.033). There was no significant difference between groups in performance on the knowledge quiz.Medical students reported higher satisfaction, engagement, and enhanced clinical decision making skills with the CYOA presentation method compared to linear case format for radiology small group learning.
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- 2022
4. First-Year Radiology Residents Teaching Anatomy to First-Year Medical Students: A Symbiotic Relationship
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Preya Shah, Mary H. Scanlon, Cole Thompson, Neal A. Rubinstein, Samantha P. Zuckerman, Maya Galperin-Aizenberg, Austin R. Pantel, and Arun C. Nachiappan
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medicine.medical_specialty ,business.industry ,education ,Anatomy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Teaching skills ,030220 oncology & carcinogenesis ,Medicine ,Gross anatomy ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Educational program ,Academic medicine - Abstract
Objectives Our institution has developed an educational program in which first-year radiology residents teach first-year medical students during gross anatomy laboratory sessions. The purpose of this study is to assess the impact of this program on medical student knowledge and perceptions of radiology, and on resident attitudes toward teaching. Materials and Methods First-year resident pairs taught small groups of medical students during weekly 15-minute interactive sessions, and were evaluated on teaching skills by senior residents. A survey about attitudes toward radiology and a knowledge quiz were sent to the medical students, and a survey about attitudes toward teaching was sent to the first-year radiology residents, both pre-course and post-course. Results Students’ radiology knowledge significantly increased between the pre-course and post-course survey across all categories tested (P Conclusions Resident-led small-group teaching sessions during anatomy laboratory are mutually beneficial for medical students and radiology residents. The program also allows radiology residents to be exposed early on in residency to teaching and academic medicine.
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- 2020
5. Thoracic Imaging of Non-Small Cell Lung Cancer Treated With Anti-programmed Death Receptor-1 Therapy
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Charu Aggarwal, Stephen J Bagley, Mark M. Hammer, Arun C. Nachiappan, Corey J. Langer, Sharyn I. Katz, Charles B. Simone, and Joshua Bauml
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0301 basic medicine ,medicine.medical_specialty ,Side effect ,business.industry ,Medical record ,Retrospective cohort study ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Monoclonal ,Carcinoma ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Lung cancer ,Pseudoprogression ,Pneumonitis - Abstract
Purpose Treatment with anti-programmed death receptor-1 (PD-1) therapeutics can lead to unconventional responses and side effect profiles due to their potentiating effects on the immune system. Here we evaluate the radiologic manifestations of anti-PD-1 therapy in the chest in patients with non-small cell lung cancer (NSCLC) receiving anti-PD-1 therapy. Materials and Methods A retrospective review of real-world clinical practice was conducted of all the patients with NSCLC receiving anti-PD-1 therapy at our institution between 2013 and 2016. All patients without adequate clinical or radiologic follow-up data in the electronic medical records were excluded. Imaging examinations for all patients deemed by their thoracic oncologists to have radiologic pseudoprogression or therapy-associated pneumonitis were reviewed by experienced thoracic radiologists. Results A total of 166 patients with NSCLC had available clinical and imaging data for retrospective review. Of these patients, 4 (2%) were considered to have radiologic pseudoprogression, 3 of which manifested as increased tumor size and 1 of which manifested with new lesions. A total of 5 patients (3%) were clinically deemed to have pneumonitis attributable to anti-PD-1 therapy, 4 of which had radiologic manifestations on computed tomography. Conclusion Radiologic pseudoprogression and drug-induced pneumonitis are uncommon but important manifestations of anti-PD-1 therapy on thoracic imaging.
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- 2019
6. Response to Letter to the Editor: Augmented Reality and Mixed Reality Head-Mounted Displays for Anatomy Education
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Joanna K. Weeks, Brian Park, Jina Pakpoor, and Arun C. Nachiappan
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Letter to the editor ,Augmented Reality ,Students, Medical ,Head (linguistics) ,Computer science ,Virtual Reality ,Virtual reality ,Anatomy education ,Mixed reality ,X ray computed ,Computer graphics (images) ,Educational Status ,Humans ,Radiology, Nuclear Medicine and imaging ,Augmented reality ,Tomography, X-Ray Computed - Published
- 2021
7. The Role of Imaging in the Management of Suspected or Known COVID-19 Pneumonia: A Multidisciplinary Perspective
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Arun C. Nachiappan, Friedrich Knollmann, Harold Litt, Rosita Shah, Sharyn I. Katz, Benoit Desjardins, Eduardo J. Mortani Barbosa, Nova Panebianco, Cameron Baston, Leonid Roshkovan, Tessa S. Cook, Narainder K. Gupta, Scott A. Simpson, Maya Galperin-Aizenberg, N.N. Chatterjee, Jeffrey C. Thompson, and Saurabh Jha
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Pulmonary and Respiratory Medicine ,Diagnostic Imaging ,medicine.medical_specialty ,Pneumonia, Viral ,Disease ,medicine.disease_cause ,Diagnosis, Differential ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Multidisciplinary approach ,Pandemic ,medicine ,Eosinophilic pneumonia ,Humans ,030212 general & internal medicine ,Intensive care medicine ,Pandemics ,Coronavirus ,Ultrasonography ,Modalities ,business.industry ,SARS-CoV-2 ,COVID-19 ,medicine.disease ,Pneumonia ,030228 respiratory system ,Radiography, Thoracic ,Differential diagnosis ,business ,Coronavirus Infections ,Tomography, X-Ray Computed - Abstract
Coronavirus disease (COVID-19) is an illness caused by a novel coronavirus that has rapidly escalated into a global pandemic leading to an urgent medical effort to better characterize this disease biologically, clinically, and by imaging. In this review, we present the current approach to imaging of COVID-19 pneumonia. We focus on the appropriate use of thoracic imaging modalities to guide clinical management. We also describe radiologic findings that are considered typical, atypical, and generally not compatible with COVID-19. Furthermore, we review imaging examples of COVID-19 imaging mimics, such as organizing pneumonia, eosinophilic pneumonia, and other viral infections.
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- 2020
8. Harnessing Augmented Reality and CT to Teach First-Year Medical Students Head and Neck Anatomy
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Joanna K. Weeks, Stephen Prouty, Jina Pakpoor, Neal A. Rubinstein, B. Park, Nicole J. Robinson, and Arun C. Nachiappan
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medicine.medical_specialty ,business.product_category ,Recall ,Headset ,education ,Article ,Mixed reality ,Session (web analytics) ,030218 nuclear medicine & medical imaging ,Visualization ,Test (assessment) ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Laptop ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Augmented reality ,Psychology ,business - Abstract
RATIONALE AND OBJECTIVES: Three-dimensional (3D) visualization has been shown to benefit new generations of medical students and physicians-in-training in a variety of contexts. However, there is limited research directly comparing student performance after using 3Dtools to those using two-dimensional (2D) screens. MATERIALS AND METHODS: A CT was performed on a donated cadaver and a 3D CT hologram was created. A total of 30 first-year medical students were randomly assigned into two groups to review head and neck anatomy in a teaching session that incorporated CT. The first group used an augmented reality headset, while the second group used a laptop screen. The students were administered a five-question anatomy test before and after the session. Two-tailed t-tests were used for statistical comparison of pretest and posttest performance within and between groups. A feedback survey was distributed for qualitative data. RESULTS: Pretest vs. posttest comparison of average percentage of questions answered correctly demonstrated both groups showing significant in-group improvement (p < 0.05), from 59% to 95% in the augmented reality group, and from 57% to 80% in the screen group. Between-group analysis indicated that posttest performance was significantly better in the augmented reality group (p = 0.022, effect size = 0.73). CONCLUSION: Immersive 3D visualization has the potential to improve short-term anatomic recall in the head and neck compared to traditional 2D screen-based review, as well as engage millennial learners to learn better in anatomy laboratory. Our findings may reflect additional benefit gained from the stereoscopic depth cues present in augmented reality-based visualization.
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- 2020
9. Disease Progression Modeling in Chronic Obstructive Pulmonary Disease
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Barry J. Make, Venkata Bandi, Douglas Stinson, Ella A. Kazerooni, Harry B. Rossiter, Farnoush Banaei-Kashani, Xavier Soler, Arun C. Nachiappan, Paul J. Friedman, Karen M. Horton, Terri H. Beaty, Christine H. Wendt, Andrew Yen, Philip F. Judy, Ferdouse Begum, Jeffrey L. Curtis, Lystra P. Hayden, Joe W. Ramsdell, Peter J. Castaldi, Alejandro P. Comellas, Emily S. Wan, Susan Murray, Aladin M. Boriek, David Pace, Jessica Bon, Nadia N. Hansel, Chandra Dass, Marilyn G. Foreman, Neil R. MacIntyre, Kartik Shenoy, David A. Lynch, Brian D. Hobbs, Raúl San José Estépar, John D. Newell, Philip Alapat, Karin F. Hoth, Stephen M. Humphries, Robert M. Steiner, Alessandra Adami, R.P. Bowler, Parag Desai, Mustafa Al Qaisi, Anna Rozenshtein, Joel L. Weissfeld, Robert A. Wise, Nan M. Laird, Margaret M. Parker, Felix J. S. Bragman, Camille M. Moore, Abbie Begnaud, Allison A. Lambert, Elizabeth Guy, Michael R. Jacobs, Mario E. Ruiz, Dawn L. DeMeo, Sungho Won, Alex Kluiber, Amit D. Parulekar, John H. M. Austin, Nathaniel Marchetti, Dandi Qiao, Douglas Everett, Joseph H. Tashjian, Juerg Tschirren, Kendra A. Young, Adel Boueiz, James D. Crapo, Gregory L. Kinney, Richard Casaburi, Russell P. Bowler, Daniel C. Alexander, Francis Cordova, Craig P. Hersh, George R. Washko, H. Page McAdams, Amir Sharafkhaneh, A. James Mamary, J. Michael Wells, Lacey Washington, MeiLan K. Han, Mark T. Dransfield, Nirupama Putcha, Craig J. Galbán, Dmitry Prokopenko, Eric A. Hoffman, Gloria Westney, Katerina Kechris, Bojidar Rangelov, Carla Wilson, Charlene McEvoy, Divay Chandra, Edwin J R van Beek, Carlos H. Martinez, Kalpatha Guntupalli, Gregory D.N. Pearson, Diego Maselli-Caceres, James C. Ross, Katherine A. Pratte, Christoph Lange, David Ciccolella, Charlie Lan, R. Graham Barr, Phuwanat Sakornsakolpat, Aditi Satti, Irene Swift, Robert H. Brown, Hans Fischer, Victor Kim, Maria Elena Vega-Sanchez, Sandra G. Adams, Belinda D’Souza, Perry G. Pernicano, Bram van Ginneken, Hrudaya Nath, Byron Thomashow, Jim Crooks, Joanne Billings, Jered Sieren, Eitan Halper-Stromberg, Matthew J. Budoff, William C. Bailey, Eva M. van Rikxoort, Merry-Lynn McDonald, Francine L. Jacobson, Edwin K. Silverman, John E. Hokanson, Robert L. Jensen, John Hughes, Michael H. Cho, Alexandra L. Young, Steven G. Kelsen, Janos Porszasz, Jacqueline B. Hetmanski, Alex Swift, John R. Hurst, Elizabeth A. Regan, Anand S Iyer, Frank C. Sciurba, Mustafa A. Atik, Gerard J. Criner, Antonio Anzueto, Sharon M. Lutz, David J. Hawkes, Carl R. Fuhrman, William W. Stringer, Harvey O. Coxson, Berend C. Stoel, Eugene Berkowitz, Joyce D. Schroeder, Tadashi Allen, Surya P. Bhatt, Matthew Strand, Brad H. Thompson, Nicola A. Hanania, Brian Bell, Teresa Gray, Gilbert E. D'Alonzo, and Richard Rosiello
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Pulmonary disease ,Critical Care and Intensive Care Medicine ,Machine Learning ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Aged ,COPD ,business.industry ,Disease progression ,Editorials ,Original Articles ,Middle Aged ,Models, Theoretical ,respiratory system ,medicine.disease ,respiratory tract diseases ,030228 respiratory system ,Disease Progression ,Bronchitis ,Female ,Ct imaging ,business ,Tomography, X-Ray Computed ,Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] - Abstract
Contains fulltext : 220761.pdf (Publisher’s version ) (Open Access) Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD) renders identifying different trajectories of disease progression challenging.Objectives: To identify subtypes of patients with COPD with distinct longitudinal progression patterns using a novel machine-learning tool called "Subtype and Stage Inference" (SuStaIn) and to evaluate the utility of SuStaIn for patient stratification in COPD.Methods: We applied SuStaIn to cross-sectional computed tomography imaging markers in 3,698 Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1-4 patients and 3,479 controls from the COPDGene (COPD Genetic Epidemiology) study to identify subtypes of patients with COPD. We confirmed the identified subtypes and progression patterns using ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) data. We assessed the utility of SuStaIn for patient stratification by comparing SuStaIn subtypes and stages at baseline with longitudinal follow-up data.Measurements and Main Results: We identified two trajectories of disease progression in COPD: a "Tissue-->Airway" subtype (n = 2,354, 70.4%), in which small airway dysfunction and emphysema precede large airway wall abnormalities, and an "Airway-->Tissue" subtype (n = 988, 29.6%), in which large airway wall abnormalities precede emphysema and small airway dysfunction. Subtypes were reproducible in ECLIPSE. Baseline stage in both subtypes correlated with future FEV1/FVC decline (r = -0.16 [P < 0.001] in the Tissue-->Airway group; r = -0.14 [P = 0.011] in the Airway-->Tissue group). SuStaIn placed 30% of smokers with normal lung function at elevated stages, suggesting imaging changes consistent with early COPD. Individuals with early changes were 2.5 times more likely to meet COPD diagnostic criteria at follow-up.Conclusions: We demonstrate two distinct patterns of disease progression in COPD using SuStaIn, likely representing different endotypes. One third of healthy smokers have detectable imaging changes, suggesting a new biomarker of "early COPD."
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- 2020
10. Radiologic Pseudoprogression during Anti–PD-1 Therapy for Advanced Non–Small Cell Lung Cancer
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Charles B. Simone, Stephen J Bagley, Jeffrey C. Thompson, Charu Aggarwal, Arun C. Nachiappan, Corey J. Langer, Sharyn I. Katz, Mark M. Hammer, and Joshua Bauml
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0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Disease Response ,business.industry ,Medical record ,Incidence (epidemiology) ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Oncology ,Response Evaluation Criteria in Solid Tumors ,030220 oncology & carcinogenesis ,medicine ,Radiology ,Nivolumab ,Lung cancer ,business ,Pseudoprogression ,Immune-Related Response Criteria - Abstract
Introduction Anti–programmed cell death protein 1 (PD-1) therapy can lead to unconventional tumor responses, including radiologic pseudoprogression. Here we have determined the real-world incidence of radiologic pseudoprogression in advanced NSCLC and compared radiologic response criteria for assessment of disease response. Methods The electronic medical records of all patients with NSCLC who were receiving anti–PD-1 therapy at our institution over a 3-year period were retrospectively reviewed, and patients with clinically suspected radiologic pseudoprogression were identified. Patients without available follow-up imaging or clinical data were excluded. Imaging examinations were then analyzed to determine whether progression was confirmed on subsequent reimaging. Assessments of tumor response by the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1 (RECIST 1.1), the unidimensional immune-related response criteria (iRRC), and the iRECIST criteria for all patients were performed and compared. Results A total of 228 consecutive patients began receiving anti–PD-1 therapy over a 3-year period. Of the 166 of these patients who were evaluable, most (80%) received nivolumab. Fifteen patients (9%) were clinically suspected of having radiologic pseudoprogression on account of tumor enlargement and/or development of new lesions on computed tomography images during the first 4 to 6 weeks of therapy, and they continued receiving anti–PD-1 therapy. Three of these patients (2%) demonstrated evidence of radiologic pseudoprogression at first reimaging. The iRRC and immune RECIST criteria were more accurate in classifying radiologic pseudoprogression as nonprogression; none of the three cases were deemed progression by the iRRC or immune RECIST, whereas all three cases were determined to be progression according to the Response Evaluation Criteria in Solid Tumors, version 1.1. Conclusions Radiologic pseudoprogression is a clinical challenge but an uncommon occurrence in patients with NSCLC who are receiving anti–PD-1 therapy.
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- 2018
11. Pulmonary Tuberculosis: Role of Radiology in Diagnosis and Management
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Girish S. Shroff, Mark M. Hammer, Daniel Ocazionez, Kasra Rahbar, Sharyn I. Katz, Elizabeth Guy, Xiao Shi, Arun C. Nachiappan, Alan E Schlesinger, and Eduardo J. Mortani Barbosa
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medicine.medical_specialty ,Tuberculosis ,business.industry ,Radiography ,MEDLINE ,Mycobacterium tuberculosis ,medicine.disease ,Bacterial Typing Techniques ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Pulmonary tuberculosis ,health services administration ,medicine ,Humans ,Radiography, Thoracic ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Radiology ,business ,Tuberculosis, Pulmonary - Abstract
Tuberculosis is a public health problem worldwide, including in the United States-particularly among immunocompromised patients and other high-risk groups. Tuberculosis manifests in active and latent forms. Active disease can occur as primary tuberculosis, developing shortly after infection, or postprimary tuberculosis, developing after a long period of latent infection. Primary tuberculosis occurs most commonly in children and immunocompromised patients, who present with lymphadenopathy, pulmonary consolidation, and pleural effusion. Postprimary tuberculosis may manifest with cavities, consolidations, and centrilobular nodules. Miliary tuberculosis refers to hematogenously disseminated disease that is more commonly seen in immunocompromised patients, who present with miliary lung nodules and multiorgan involvement. The principal means of testing for active tuberculosis is sputum analysis, including smear, culture, and nucleic acid amplification testing. Imaging findings, particularly the presence of cavitation, can affect treatment decisions, such as the duration of therapy. Latent tuberculosis is an asymptomatic infection that can lead to postprimary tuberculosis in the future. Patients who are suspected of having latent tuberculosis may undergo targeted testing with a tuberculin skin test or interferon-γ release assay. Chest radiographs are used to stratify for risk and to assess for asymptomatic active disease. Sequelae of previous tuberculosis that is now inactive manifest characteristically as fibronodular opacities in the apical and upper lung zones. Stability of radiographic findings for 6 months distinguishes inactive from active disease. Nontuberculous mycobacterial disease can sometimes mimic the findings of active tuberculosis, and laboratory confirmation is required to make the distinction. Familiarity with the imaging, clinical, and laboratory features of tuberculosis is important for diagnosis and management.
- Published
- 2017
12. Delayed-Phase Enhancement for Evaluation of Malignant Pleural Mesothelioma on Computed Tomography: A Prospective Cohort Study
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Ian Berger, Joseph DiRienzi, Drew A. Torigian, E. Paul Wileyto, Andrew R. Haas, Akash R. Patel, Sharyn I. Katz, Maya Galperin-Aizenberg, Arun C. Nachiappan, Evan W. Alley, Urooj Khalid, Keith A. Cengel, Eduardo J. Mortani Barbosa, Leonid Roshkovan, Sunil Singhal, and Sally McNulty
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Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Cancer Research ,medicine.medical_specialty ,Time Factors ,Pleural Neoplasms ,medicine.medical_treatment ,Computed tomography ,Malignancy ,Cohort Studies ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Lung cancer ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Pleural mesothelioma ,Mesothelioma, Malignant ,Middle Aged ,medicine.disease ,Tumor Burden ,Radiation therapy ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Female ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Pleurodesis - Abstract
BACKGROUND Radiologic assessment of malignant pleural mesothelioma (MPM) on computed tomography (CT) imaging can be limited by similar attenuations of MPM and adjacent tissues. This can result in inaccuracies in defining the presence and extent of pleural tumor burden. We hypothesized that increasing the time delay for pleural enhancement will optimize discrimination between MPM and noncancerous tissues on CT. Here we conduct a prospective observational study to determine the optimal time delay for imaging MPM on CT. PATIENTS AND METHODS Adult MPM patients (n = 15) were enrolled in this prospective exploratory imaging trial. Patients with < 1 cm MPM thickness, prior pleurectomy, pleurodesis, pleural radiotherapy, or antiangiogenic therapy were excluded. All patients underwent a dynamically-enhanced CT with multiple time delays (0 - 10 minutes) after intravenous contrast administration. Tumor tissue attenuation was measured at each phase of enhancement. A qualitative assessment of tumor enhancement kinetics was also performed. The optimal phase of enhancement based on qualitative lesion conspicuity and quantitative tumor enhancement was then compared. RESULTS MPM tumor enhancement was quantitatively and qualitatively increased at time delays beyond the conventional time delay for thoracic CT imaging (40-60 seconds). Patient tumor enhancement kinetics, displayed as the fraction of maximal tumor tissue attenuation as a function of time, revealed an optimal time delay of 230 to 300 seconds after intravenous contrast administration. There was an association between degree of tumor enhancement and subjective lesion conspicuity. CONCLUSION Optimal MPM contrast enhancement occurs at a later phase than typically acquired with conventional thoracic CT imaging.
- Published
- 2021
13. Patient-Centered and Specialty-Specific Case Work-Up: An Effective Method for Teaching Appropriateness of Imaging to Medical Students
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Sean Novak, Sharyn I. Katz, Arun C. Nachiappan, John M. Choi, Mike Sheng, Scott Simpson, Eleanor Gillis, and Preya Shah
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Research design ,medicine.medical_specialty ,Students, Medical ,Teaching method ,education ,Specialty ,Session (web analytics) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Patient-Centered Care ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Curriculum ,business.industry ,Teaching ,Preceptor ,Problem-Based Learning ,Work-up ,030220 oncology & carcinogenesis ,Active learning ,Educational Status ,business ,Radiology - Abstract
Our institution has developed a mini-course program within the diagnostic radiology elective curriculum that promotes active learning, using patient cases specifically tailored to students' future specialties. The purpose of this study is to evaluate the effectiveness of this mini-course on medical student knowledge of imaging appropriateness and attitude toward radiologist consultation.During each month-long radiology elective course, students were divided into teams of up to four students based on their specialty interest and assigned recent patient cases with imaging findings relevant to their specialties. The students researched their customized patient cases, integrated pertinent clinical and imaging findings, and presented their findings in a final preceptor-led session. A five-point Likert-type item preprogram and postprogram survey assessing knowledge of imaging appropriateness and attitude toward radiologist consultation was sent to the enrolled medical students.Out of 36 medical students, 33 (92%) completed the preprogram survey and 31 (86%) completed the postprogram survey. Students reported improved confidence in knowledge of imaging appropriateness, such as indications for intravenous contrast (p0.0005) and oral contrast (p0.0005). Furthermore, students reported an improved understanding of how to utilize radiologists (p0.005) and how to provide pertinent clinical historical information when requesting a radiology exam (p0.0005). Students reported that researching the patient's historical and clinical information in conjunction with the radiology images made them more invested in the case.Assigning customized patient cases to medical students on diagnostic radiology elective, tailored to their future specialties, is an effective and active way to teach imaging appropriateness and to improve attitudes toward radiologist consultation.
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- 2018
14. Impact of Early Radiology Research Experiences on Medical Student Perceptions of Radiology and Research
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Scott O. Trerotola, Arun C. Nachiappan, Sharyn I. Katz, David A. Mankoff, Preya Shah, Mike Sheng, Eduardo J. Mortani Barbosa, and Maya Galperin-Aizenberg
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Student perceptions ,medicine.medical_specialty ,Biomedical Research ,Students, Medical ,business.industry ,education ,Specialty ,Research skills ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,ComputingMilieux_COMPUTERSANDEDUCATION ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Abstract
Rationale and objectives To promote opportunities for medical students to gain early exposure to radiology and research, our institution has initiated programs which fund summer radiology research projects for rising second-year medical students. This study assesses the impact of these faculty-mentored summer research experiences on medical student perceptions of radiology and research, in terms of both knowledge and interest. Materials and methods A voluntary, anonymous survey was administered to students both before and after the summer research period. Both the pre-program survey and post-program survey included 7-point Likert-scale questions (1 = strongly disagree; 7 = strongly agree) to evaluate students’ perceptions about research and students’ perceptions about radiology as a specialty. Faculty mentors were sent an analogous post-program survey that included an evaluation of their student's research skills. Results The surveys were completed by 9 of 11 students and 10 of 11 mentors. Students’ perceived knowledge of radiology as a specialty improved (P = 0.02) between the pre-program survey and post-program survey. Similarly, there was an increase in students’ perceived knowledge of research skills (P = 0.02) between the pre-program survey and post-program survey, with student ratings of research skills consistent with those of mentors. High student interest in both radiology and research was maintained over the course of the program. Conclusion Our pilot study suggests that summer research experiences can improve knowledge of radiology and research among medical students. Continued evaluation of this annual program will allow us to enhance the benefit to medical students and thereby bolster interest in academic radiology.
- Published
- 2018
15. Imaging of Intrathoracic Paragangliomas
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Horacio Murillo, Daniel Ocazionez, Arun C. Nachiappan, Carlos S. Restrepo, Ameya Baxi, Abhishek Chaturvedi, Girish S. Shroff, Daniel Vargas, and Demetrius L. Dicks
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Surgical resection ,Adult ,Male ,medicine.medical_specialty ,Computed tomography ,Aortopulmonary window ,030218 nuclear medicine & medical imaging ,Paraganglioma ,03 medical and health sciences ,Preoperative embolization ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Vascular supply ,Selective angiography ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Middle Aged ,Thoracic Neoplasms ,medicine.disease ,030220 oncology & carcinogenesis ,Positron-Emission Tomography ,Female ,Radiology ,business ,Posterior mediastinum - Abstract
Intrathoracic paragangliomas are uncommon and only represent 1%-2% of paragangliomas. They are most commonly found in mediastinal compartments (aortopulmonary window or posterior mediastinum). Computed tomography, magnetic resonance, and specific nuclear medicine radiotracers are routinely used to characterize these lesions and help exclude other more common conditions. Selective angiography is currently used for preoperative embolization and mapping of the vascular supply before surgical resection, rather than for diagnostic purposes alone.
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- 2017
16. The value of delayed phase enhanced imaging in malignant pleural mesothelioma
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Urooj Khalid, Evan W. Alley, Maya Galperin-Aizenberg, Andrew R. Haas, Narainder K. Gupta, Warren B. Gefter, Akash M. Patel, Drew A. Torigian, Charles B. Simone, Arun C. Nachiappan, E. Paul Wileyto, Sharyn I. Katz, Eduardo J. Mortani Barbosa, Ian Berger, Keith A. Cengel, and Sunil Singhal
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,Pleural mesothelioma ,business.industry ,Local tumor invasion ,Pleural Tumor ,Magnetic resonance imaging ,Delayed phase ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,Tumor enhancement ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Dynamic contrast-enhanced MRI ,medicine ,Original Article ,Radiology ,medicine.symptom ,business - Abstract
Cross-sectional imaging of malignant pleural mesothelioma (MPM) can underestimate the presence of local tumor invasion. Since accurate staging is vital optimal choice of therapy, techniques that optimize pleural imaging are needed. Here we estimate the optimal timing of MPM enhancement on magnetic resonance imaging (MRI).All MPM patients with intravenous (IV) contrast enhanced staging MRI between 2000-2016 at our institution were retrospectively selected for image analysis. Patients with incomplete imaging protocol and maximum pleural tumor thickness1 cm were excluded. Quantitative measurements of tumor signal intensity were obtained on pre-contrast and post-contrast phases where MRI acquisition parameters were fixed. Using best-fit model curves, predicted maximum time points of enhancement were determined using a simulation of predicted values. Additionally, a qualitative assessment of tumor conspicuity was performed at all IV contrast time delays imaged. A statistical analysis assessed for correlation between qualitative lesion conspicuity and quantitative tumor enhancement.Of the 42 MPM patients who had undergone staging MRI during the study period, 12 patients met the study criteria. Peak tumor enhancement was between 150 and 300 sec following IV contrast administration. Within this time window, 80% of patients are projected to have reached80%,85%, and90% peak tumor enhancement. There was a statistically significant correlation between increasing tumor enhancement and subjective lesion conspicuity.Optimal MPM enhancement on MRI likely occurs at a time delay between 2.5-5 min following IV contrast administration. Further study of delayed phase enhancement of MPM with dynamic contrast enhanced MRI is warranted.
- Published
- 2017
17. Limited Utility of Pulmonary Nodule Risk Calculators for Managing Large Nodules
- Author
-
Mark M. Hammer, Arun C. Nachiappan, and Eduardo J. Mortani Barbosa
- Subjects
Male ,medicine.medical_specialty ,Lung Neoplasms ,Biopsy ,Risk Assessment ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Pulmonary nodule ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Lung cancer ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Patient Selection ,Solitary Pulmonary Nodule ,Nodule (medicine) ,Middle Aged ,medicine.disease ,Predictive value ,Optimal management ,Tumor Burden ,030220 oncology & carcinogenesis ,Predictive value of tests ,Tissue diagnosis ,Female ,Radiology ,medicine.symptom ,business ,Tomography, X-Ray Computed - Abstract
Rationale and Objectives The optimal management of large pulmonary nodules, at higher risk for lung cancer, has not been determined, and it remains unclear as to which patients should undergo follow-up imaging vs invasive tissue diagnosis via biopsy or surgical resection. Materials and Methods Through search of radiology reports, 86 nodules from our institution were identified using the inclusion criterion of solid nodules measuring greater than 8 mm. We evaluated these nodules with a number of risk prediction calculators, including the Brock University model, and compared these against the proven diagnosis. Results Of 86 nodules, 59 (69%) nodules were malignant. The most accurate predictive model, the Brock University calculator, underestimated the risk for this group at 33%. At its optimal threshold, this model had a positive predictive value of 81% and negative predictive value of 53%. Notwithstanding the low negative predictive value, the positive predictive value was no better than patients clinically selected for biopsy (86% of biopsies were malignant). Conclusion Existing nodule risk prediction calculators are of limited usage in guiding the management of large pulmonary nodules. At present, the accuracy of these models in this setting is inferior to expert clinical judgment, and future work is needed to develop management algorithms for higher-risk nodules.
- Published
- 2017
18. 729. Comparing Length of Stay and Clinical Outcomes for Hospitalized Patients at Bridgeport Hospital who Received Baloxavir Marboxil (BM) or Oseltamivir Phosphate (OP) During the 2018–2019 Influenza Season
- Author
-
Arun C Nachiappan and Wei-Teng Yang
- Subjects
medicine.medical_specialty ,Oseltamivir ,business.industry ,Hospitalized patients ,Influenza season ,medicine.disease ,Intensive care unit ,law.invention ,Pneumonia ,chemistry.chemical_compound ,Abstracts ,Infectious Diseases ,Oncology ,chemistry ,law ,Internal medicine ,Oseltamivir Phosphate ,Poster Abstracts ,medicine ,Bronchitis ,business ,Asthma - Abstract
Background BM has been approved for the management of acute uncomplicated influenza in otherwise healthy individuals between age 12 and 64, and found to have a greater reduction in viremia. The original trial excluded hospitalized patients and those with co-morbidities. Methods This is a single-center, retrospective analysis of hospitalized patients diagnosed with influenza between October 1, 2018 and March 31, 2019. This study excluded those diagnosed before the addition of BM to the hospital formulary; those who were not treated with antivirals, treated before admission, or treated with both antivirals; those younger than 12 years old; and those who remain hospitalized. The relationship between length of stay and antiviral used was ascertained using t-test and multivariate linear regression. Due to heterogeneity in reasons for hospitalization, analysis was stratified by the main reasons for hospitalization. T-test and Wilcoxon’s rank-sum test were used for continuous variables, and Pearson’s chi-squared test was used for categorical variables. The significance level was 0.05. Results The study population (n = 145) has a mean age of 66.5 years; of whom, 43% are male. In terms of patient characteristics, those treated with BM (n = 105) vs. OP (n = 40) were older, less frequently admitted to ICU and of differing ethnic composition. The length of stay was similar in those treated with BM vs. OP in both univariate and multivariate linear regression (5.5 (5.3) vs. 8.2 (11.4) days, P = 0.33). In addition, the length of stay was similar in those treated with BM vs. OP when stratified by reasons for hospitalization: pneumonia/bronchitis (6.6 (7.1) vs. 8.2 (9.2) days, P = 0.43), obstructive airway disease exacerbation (5.5 (4.8) vs. 4.8 (8.0) days, P = 0.56), elderly with multiple co-morbidities (5.0 (4.0) vs. 3.4 (6.8) days, P = 0.63), reactive airway disease (4.1 (4.8) vs. 7.4 (1.5) days, P = 0.27) or congestive heart failure exacerbation (9.8 (9.0) vs. 5.6 (5.0) days, P = 0.43). Conclusion In hospitalized patients with co-morbidities diagnosed with influenza, there was no difference in length of stay in those who received BM vs. OP. This highlights the need to clarify the role of BM in this population, particularly given its comparable symptom reduction, greater cost, and the emergence of PA138T viral mutant. Disclosures All authors: No reported disclosures.
- Published
- 2019
19. Bronchobiliary Fistula Localized by Cholescintigraphy with Single-Photon Emission Computed Tomography
- Author
-
Arun C. Nachiappan, Maddy Artunduaga, Niraj Patel, Elizabeth Guy, and Julie A Wendt
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,bronchobiliary fistula ,Preoperative planning ,medicine.diagnostic_test ,single-photon emission computed tomography ,business.industry ,lcsh:R895-920 ,Rare entity ,Case Report ,Single-photon emission computed tomography ,Cholescintigraphy ,cholescintigraphy ,Biliptysis ,medicine ,Bronchobiliary fistula ,Radiology ,Surgical treatment ,business ,Nuclear medicine ,Emission computed tomography - Abstract
Biliptysis is an important clinical feature to recognize as it is associated with bronchobiliary fistula, a rare entity. Bronchobiliary fistulas have been diagnosed with planar cholescintigraphy. However, cholescintigraphy with single-photon emission computed tomography (SPECT) can better spatially localize a bronchobiliary fistula as compared to planar cholescintigraphy alone, and is useful for preoperative planning if surgical treatment is required. Here, we present the case of a 23-year-old male who developed a bronchobiliary fistula in the setting of posttraumatic and postsurgical infection, which was diagnosed and localized by cholescintigraphy with SPECT.
- Published
- 2015
20. Pathology of the Trachea and Central Bronchi
- Author
-
Carlos S. Restrepo, Daniel Ocazionez, Girish S. Shroff, Pushpender Gupta, Daniel Vargas, Arun C. Nachiappan, Carol C. Wu, and Brett W. Carter
- Subjects
Pathology ,medicine.medical_specialty ,Tracheal Diseases ,Contrast Media ,Computed tomography ,030218 nuclear medicine & medical imaging ,Computed tomographic ,03 medical and health sciences ,0302 clinical medicine ,X ray computed ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Bronchial Diseases ,medicine.diagnostic_test ,business.industry ,food and beverages ,respiratory system ,Tomography x ray computed ,Lung disease ,030220 oncology & carcinogenesis ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
A wide variety of disorders can affect the trachea and central bronchi. Computed tomography is the imaging modality of choice in the evaluation of tracheobronchial disease. Tracheobronchial abnormalities are sometimes incidentally detected on routine imaging or when imaging is performed for another reason. Abnormalities of the tracheobronchial tree, however, can be easily missed because they can be subtle. Furthermore, because symptoms in patients with tracheobronchial disorders often overlap symptoms of lung disease, radiologists may focus their attention on the lungs and overlook the tracheobronchial tree. In this article, we review a wide range of tracheobronchial diseases with emphasis on their computed tomographic appearances.
- Published
- 2016
21. Laparoscopic sleeve gastrectomy: a guide to postoperative anatomy and complications
- Author
-
Carlos A. Farinas, David P. Katz, Felix Spiegel, Arun C. Nachiappan, Marc H. Willis, Cliff J. Whigham, Stephen R. Lee, and Collin D. Bray
- Subjects
medicine.medical_specialty ,Laparoscopic sleeve gastrectomy ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Urology ,medicine.medical_treatment ,General surgery ,education ,Gastroenterology ,General Medicine ,Anatomy ,Obesity, Morbid ,Postoperative Complications ,Tomography x ray computed ,Gastrectomy ,X ray computed ,medicine ,Humans ,Laparoscopy ,Radiology, Nuclear Medicine and imaging ,Tomography, X-Ray Computed ,business - Abstract
The purpose of this pictorial essay is to review the surgical technique, postoperative anatomy, and potential complications of the laparoscopic sleeve gastrectomy. As the laparoscopic sleeve gastrectomy becomes an increasingly popular bariatric surgery, it is important for radiologists to familiarize themselves with the procedure and possible complications.
- Published
- 2011
22. Postoperative Imaging in Liver Transplantation: What Radiologists Should Know
- Author
-
Giles W. Boland, Hetal A Verma, Raul N. Uppot, Ajay K. Singh, Sanjay Saini, Arun C. Nachiappan, and Michael A. Blake
- Subjects
medicine.medical_specialty ,Biliary Tract Diseases ,medicine.medical_treatment ,Liver transplantation ,Scintigraphy ,Diagnosis, Differential ,Liver disease ,Cholangiography ,medicine ,Medical imaging ,Humans ,Radiology, Nuclear Medicine and imaging ,Vascular Diseases ,Abscess ,Magnetic resonance cholangiopancreatography ,Endoscopic retrograde cholangiopancreatography ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Endoscopy ,medicine.disease ,Liver Transplantation ,surgical procedures, operative ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
Liver transplantation is now frequently used in the treatment of end-stage liver disease. Therefore, it is important that radiologists be aware of common anastomotic techniques and expected postoperative imaging findings. Imaging is most useful in evaluating for posttransplantation complications, which are broadly classified into vascular, biliary, and other complications. Hepatic artery thrombosis is the most significant complication and is often associated with graft failure. Radiologists have multiple modalities at their disposal for optimal evaluation. Doppler ultrasonography (US) is the preliminary imaging modality for gross evaluation of the liver parenchyma, biliary tree, and vasculature for abnormalities. When US findings are indeterminate or there is persistent clinical suspicion for an abnormality, computed tomography (CT) is often performed. The major indications for CT are detection of bile leak, hemorrhage, and abscess, but CT is also useful in the assessment of the vasculature. T-tube cholangiography and magnetic resonance cholangiopancreatography are the best noninvasive imaging tools for evaluating for biliary stricture. Some investigators would argue that endoscopic retrograde cholangiopancreatography (ERCP) is a better diagnostic imaging modality; however, ERCP is invasive. Hepatobiliary scintigraphy is optimal for the evaluation of biliary leakage. Early detection of posttransplantation complications will help lower morbidity rates and will likely allow graft salvage in selected cases.
- Published
- 2010
23. Case 195
- Author
-
Farbod Nasseri, Geraldine J. Chen, and Arun C. Nachiappan
- Subjects
Radiology, Nuclear Medicine and imaging - Published
- 2013
24. E-cigarettes: promise or threat?
- Author
-
Arun C. Nachiappan and T. S. Selvavinayagam
- Abstract
Use of the electronic cigarette or electronic nicotine delivery system (ENDS) is increasing globally. Its vapour delivers nicotine without the 6000 odd chemicals released during cigarette smoking and the associated harm. Experts are divided on whether ENDS promise reduction in tobacco use or threaten tobacco control. This review presents up-to-date evidence. Two trials showed an increase in cessation, but not a reduction in cigarette use. Eight cohort studies showed no increase in cessation, and two cohort studies and a recent trial showed an increased reduction in cigarette use. A US population study showed association between ENDS use and smoking cessation. Nicotine addiction and potential harm to non-smokers who use ENDS are key concerns. Nicotine affects lung and brain development. An increase in accidental poisoning, though mild, is reported in children. No significant short term health effects are reported. When heated, ENDS may emit potential toxic and carcinogenic substances such as aldehydes, acrolein, flavouring agents etc. at very low levels - but their long term impact is not known. ENDS bring potential benefits to smokers, but there are concerns about their potential for nicotine addiction, gateway effect and renormalisation of smoking. However, in the UK and the US, a rise in ENDS use is associated with a fall in the prevalence of smoking. Countries differ in their approach to ENDS. India seems to be edging towards a total ban. India should collect local data and conduct research to monitor the impact and make informed, evidence based decisions, where needed.
- Published
- 2017
25. CT Dose Reduction Workshop: An Active Educational Experience
- Author
-
Shelley Kumar, Leonardo I. Valentin, Podimannil S. Philip, Arun C. Nachiappan, Rafael A. Vicens, Zeyad A. Metwalli, Erik V. Soloff, and Alfred Delumpa
- Subjects
Protocol (science) ,medicine.medical_specialty ,Quality management ,business.industry ,education ,Radiation dose ,Internship and Residency ,Resident education ,Radiation Dosage ,Quality Improvement ,Confidence interval ,Patient safety ,Radiation Protection ,Education, Medical, Graduate ,Surveys and Questionnaires ,Renal mass ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Dose reduction ,Patient Safety ,business ,Radiology ,Tomography, X-Ray Computed - Abstract
Purpose: Improving patient safety by minimizing CT radiation dose, while maintaining diagnostic image quality, has become an important skill in diagnostic radiology. The aim of this study was to examine the value of an educational workshop for optimizing CT protocols in an academic department, and to assess its impact on resident education. Methods: The CT Dose Reduction Workshop met monthly for 1 year, to teach and implement dose reduction strategies. Changes were made to CT protocols through group consensus while participants kept up to date with current literature. A survey was sent to 48 radiology residents and 32 attending radiologists in the department, including both participants and nonparticipants, after completion of the workshop, to assess its utility. The survey used a 5-point Likert-type scale. Average doses for a specific CT protocol before and after the workshop were compared. Results: About 80% of respondents agreed or strongly agreed that the workshop was essential. Workshop participants expressed greater confidence in their knowledge of dose reduction techniques, with a mean score of 3.74 (95% confidence interval, 3.35-4.13), compared with nonparticipants, who had a mean score of 3.00 (95% confidence interval, 2.64-3.36) (P < .01). Dose reductions were established across numerous CT protocols. For instance, the average total dose-length product in renal mass protocol CT examinations decreased by 54% (P < .0001). Conclusions: A CT dose reduction workshop increases participants’ confidence in knowledge of dose reduction techniques, fosters a culture of safety and quality improvement in the department, and reduces radiation dose to patients.
- Published
- 2014
26. The Effect of Needle Gauge on the Risk of Pneumothorax and Chest Tube Placement After Percutaneous Computed Tomographic (CT)-Guided Lung Biopsy
- Author
-
Joe Ensor, Sanjay Gupta, Rony Avritscher, Asher Philip, J. Kuban, Steven Y. Huang, Arun C. Nachiappan, Geraldine J. Chen, Armeen Mahvash, Ravi Murthy, Alda L. Tam, Michael J. Wallace, David C. Madoff, Kamran Ahrar, and Judy Ahrar
- Subjects
Adult ,Image-Guided Biopsy ,Male ,medicine.medical_specialty ,Percutaneous ,Adolescent ,Lung biopsy ,Radiography, Interventional ,Cohort Studies ,Young Adult ,Risk Factors ,Biopsy ,NEEDLE GAUGE ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Child ,Lung ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Biopsy, Needle ,Pneumothorax ,Equipment Design ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Chest tube placement ,medicine.anatomical_structure ,Needles ,Chest Tubes ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed - Abstract
The aim of this study was to evaluate the effect of coaxial guide needle gauge (18 vs. 19 gauge) on the risk of pneumothorax and chest tube placement after CT-guided lung biopsy. Imaging records of all patients who had undergone CT-guided lung biopsies at our institution from March 1, 2006 to December 9, 2010 were retrospectively reviewed. Univariate and multivariate logistic regression analyses were performed to assess the effect of various patient-, lesion-, and procedure-related variables on subsequent pneumothorax and chest tube placement rates. The study included 4262 biopsies (2304 with 18-gauge and 1958 with 19-gauge coaxial guide needles) in 3917 patients. The rates of pneumothorax and chest tube placement were 30.2 and 15 %, respectively. Pneumothorax occurred in 35 % of procedures performed with 18-gauge needles and in 24.5 % of procedures performed with 19-gauge needles (p
- Published
- 2014
27. Operator radiation dose reduction during fluoroscopic interventional procedures
- Author
-
Arun C. Nachiappan, John A. Hancock, David M. Wynne, Ray Cody Mayo, Cliff J. Whigham, Gary L. Horn, Benjamin R. Archer, and Stephanie C. Spann
- Subjects
medicine.medical_specialty ,Safety Management ,business.industry ,Radiography ,medicine.medical_treatment ,Radiation dose ,Radiation Exposure ,Radiography, Interventional ,Texas ,Radiation exposure ,Operator (computer programming) ,Radiation Protection ,Occupational Exposure ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Occupational exposure ,Radiation protection ,business ,Nuclear medicine ,Radiology ,Reduction (orthopedic surgery) - Published
- 2014
28. Case 195: chondrosarcoma of the posterior mediastinum
- Author
-
Geraldine J. Chen, Arun C. Nachiappan, and Farbod Nasseri
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Biopsy ,Iohexol ,Chondrosarcoma ,Contrast Media ,Ring (chemistry) ,Mediastinal Neoplasms ,Arc (geometry) ,Diagnosis, Differential ,Meglumine ,medicine ,Organometallic Compounds ,Humans ,Radiology, Nuclear Medicine and imaging ,business.industry ,Anatomy ,Middle Aged ,musculoskeletal system ,medicine.disease ,Magnetic Resonance Imaging ,Female ,Radiography, Thoracic ,Radiology ,Signal intensity ,business ,Tomography, X-Ray Computed ,Posterior mediastinum - Abstract
Although chondrosarcoma is rare in the spine, it should be considered when there is a ring and arc appearance of calcifications within adjacent bone and heterogeneous high T2 signal intensity within a paraspinal mass.
- Published
- 2013
29. Clinically oriented three-year medical physics curriculum: a new design for the future
- Author
-
Marc H. Willis, Matthew R. Galfione, Raj R. Chinnappan, Arun C. Nachiappan, Pedro J. Diaz-Marchan, Stewart C. Bushong, and Stephen R. Lee
- Subjects
Medical education ,medicine.medical_specialty ,business.industry ,education ,Biophysics ,Internship and Residency ,Resident education ,General Medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Curriculum ,Journal club ,business ,Radiology ,Health Physics - Abstract
OBJECTIVE. Medical physics instruction for diagnostic radiology residency at our institution has been redesigned with an interactive and image-based approach that encourages clinical application. The new medical physics curriculum spans the first 3 years of radiology residency and is integrated with the core didactic curriculum. CONCLUSION. Salient features include clinical medical physics conferences, fundamentals of medical physics lectures, practicums, online modules, journal club, and a final review before the American Board of Radiology core examination.
- Published
- 2012
30. Large Multilocular Thymic Cyst: A Rare Finding in an HIV Positive Adult Female
- Author
-
Farbod Nasseri, Arun C. Nachiappan, David M Berger, and Xiao Shi
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Pathology ,medicine.medical_specialty ,Multilocular Thymic Cyst ,lcsh:R895-920 ,Human immunodeficiency virus (HIV) ,Case Report ,Thymic cyst ,medicine.disease_cause ,Acquired immunodeficiency syndrome (AIDS) ,thymus ,Rare case ,mental disorders ,parasitic diseases ,medicine ,Radiology, Nuclear Medicine and imaging ,follicular hyperplasia ,music ,music.instrument ,Adult female ,business.industry ,virus diseases ,HIV ,medicine.disease ,Follicular hyperplasia ,AIDS ,multilocular thymic cyst ,Immunology ,business - Abstract
Multilocular thymic cysts with follicular hyperplasia are uncommon masses that occur in Human Immunodeficiency Virus (HIV) positive individuals. These cysts mostly present in HIV positive children. Here we report a rare case of multilocular thymic cyst in an HIV positive adult female. In this case report, the radiologic findings of multilocular thymic cyst, management and prognosis are discussed.
- Published
- 2012
31. A proposed medical physics curriculum: preparing for the 2013 ABR examination
- Author
-
Arun C. Nachiappan, David M. Wynne, David P. Katz, Stewart C. Bushong, and Marc H. Willis
- Subjects
Diagnostic Imaging ,Educational measurement ,Medical education ,medicine.medical_specialty ,business.industry ,Physics ,education ,Internship and Residency ,United States ,Education, Medical, Graduate ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Curriculum revision ,sense organs ,Curriculum ,Educational Measurement ,business ,Radiology ,Residency training - Abstract
The upcoming ABR examination format for radiology residents is undergoing significant changes in 2013. This requires adaptation of the didactic curriculum for radiology residents entering in July 2010 to meet these changes. Physics will now be incorporated into the core (qualifying) examination during the third year of residency, instead of being tested as a separate examination that was often taken earlier in residency training in past years. In this article, the authors discuss the past, present, and future of medical physics instruction and outline a revised medical physics curriculum for radiology residents that has been internally approved for implementation at the authors' institution and has not been advocated by any society or by the ABR. Starting with this article, the authors hope to encourage a discussion of physics curriculum revision with other institutions.
- Published
- 2010
32. Radiofrequency ablation in the lung complicated by positive airway pressure ventilation
- Author
-
Jo-Anne O. Shepard, Michael Lanuti, Amita Sharma, and Arun C. Nachiappan
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Lung Neoplasms ,Radiofrequency ablation ,medicine.medical_treatment ,Bronchopleural fistula ,Bone Neoplasms ,Histiocytoma, Malignant Fibrous ,Risk Assessment ,law.invention ,Positive-Pressure Respiration ,law ,mental disorders ,Positive airway pressure ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,In patient ,Continuous positive airway pressure ,Neoplasm Staging ,Lung ,business.industry ,Palliative Care ,Pneumothorax ,respiratory system ,Middle Aged ,Pleural Diseases ,medicine.disease ,Ablation ,Combined Modality Therapy ,respiratory tract diseases ,Surgery ,Scapula ,medicine.anatomical_structure ,Treatment Outcome ,Breathing ,Catheter Ablation ,Bronchial Fistula ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,psychological phenomena and processes ,Follow-Up Studies - Abstract
A patient receiving bilevel positive airway pressure therapy underwent radiofrequency ablation of a pulmonary metastasis from a primary malignant fibrous histiocytoma of the scapula. The patient's postablation course was complicated by a bronchopleural fistula, which was exacerbated by the detrimental effects of positive airway pressure on necrotic lung tissue after the ablation. The use of positive airway pressure devices, including bilevel positive airway pressure and continuous positive airway pressure, in patients undergoing radiofrequency ablation of the lung should be considered as an added risk for developing bronchopleural fistula.
- Published
- 2009
33. Hyperdense Endobronchial Mass - A Rare Manifestation of Metastatic Melanoma
- Author
-
Chul Y Chung, Arun C. Nachiappan, Neda Zarrin-Khameh, and Gauruv S Likhari
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Pathology ,medicine.medical_specialty ,Lung ,Metastatic melanoma ,business.industry ,Melanoma ,lcsh:R895-920 ,Case Report ,multidetector computed tomography ,Endobronchial Mass ,medicine.disease ,Metastasis ,medicine.anatomical_structure ,Endobronchial ,Multidetector computed tomography ,medicine ,melanoma ,metastasis ,Radiology, Nuclear Medicine and imaging ,Differential diagnosis ,business ,neoplasms - Abstract
Parenchymal lung metastases are common in malignant melanoma. However, endobronchial metastatic melanoma is uncommon. In this report, we describe a patient with a hyperdense endobronchial mass diagnosed as a melanoma metastasis. We review the imaging findings of pulmonary metastatic melanoma and discuss the differential diagnosis of an endobronchial mass in adults.
- Published
- 2014
34. Case Report: Tuberculosis IRIS : a mediastinal problem
- Author
-
Andrew R. DiNardo, Laila Woc-Colburn, Leonardo I. Valentin, Elizabeth Y. Chiao, and Arun C. Nachiappan
- Subjects
Pathology ,medicine.medical_specialty ,Tuberculosis ,Perforation (oil well) ,Case Report ,General Biochemistry, Genetics and Molecular Biology ,Mycobacterium tuberculosis ,Immune reconstitution inflammatory syndrome ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Iris (anatomy) ,General Pharmacology, Toxicology and Pharmaceutics ,HIV Infection & AIDS: Clinical ,Mycobacterium tuberculosis, Immune Reconstitution Inflammatory Syndrome, HAART ,biology ,General Immunology and Microbiology ,Esophageal wall ,business.industry ,Articles ,Bacterial Infections ,General Medicine ,biology.organism_classification ,medicine.disease ,Antiretroviral therapy ,medicine.anatomical_structure ,Immunology ,Clinical Immunology ,business - Abstract
We present a case of a 39-year-old male patient with Acquired Immune Deficiency Syndrome (AIDS) who developed Mycobacterium tuberculosis related Immune Reconstitution Inflammatory Syndrome (IRIS) after initiation of Highly Active Antiretroviral Therapy (HAART) treatment. The inflammatory response resulted in mediastinal necrotic lymphadenopathy and subsequent perforation of the esophageal wall.
- Published
- 2013
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