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WOS: 000311653300001 In this study, the evaluation of therapeutic effects of probiotic bacteria, in comparison with single supportive and symptomatic therapy. in CPV (canine parvovirus) infection was aimed. A total of 20 naturally infected dogs, 1-6 months old, exhibiting enteritis and for which the diagnosis were confirmed by an ELISA commercially available test, were randomly divided into two equal groups. Only supportive and symptomatic therapy was applied in group I, whereas a commercial probiotic product which contained different probiotic bacteria (VSL#3) was used as adjuvant oral therapy in the group II. Clinical scores established from complete clinical examinations performed at the beginning and on every subsequent day during the therapy and haematological parameters determined before and 5 days after treatments were compared between the 2 groups. A moderate anaemia (low haemoglobinemia) coupled to reduction in the mean corpuscular volume and haemoglobin concentration was evidenced in 55% of parvovirus infected clogs and a relatively leukopenia when compared with after the treatment was observed in all diseased animals. Seven (70%) and nine (90%) dogs in the groups I and II respectively, survived during the trial. Moreover, the clinical scores have declined significantly more rapidly in the group II than in the group I. While the erythrocyte parameters have not significantly differed between the 2 groups, leukocyte and lymphocyte numerations were significantly improved during the treatment course only in clogs additionally treated with probiotics. The present study indicates that probiotics may be beneficial in CPV therapy. especially for shortening the recovery time, under optimal care conditions. Commission of Scientific Research Projects of Ondokuz Mayis UniversityOndokuz Mayis University [VET- 014] This study was supported by the Commission of Scientific Research Projects of Ondokuz Mayis University (Project No: VET- 014).

WOS: 000287897300001 In this study, the effects of florfenicol and tulathromycin on clinical recovery and acute-phase proteins in bovine respiratory diseases (BRD) were evaluated under the field conditions. A total of 30 local race feedlot cattle were used in the study. Twenty naturally infected beef and 10 healthy beef were used for the experimental and control groups, respectively. Sick animals were randomly divided into two groups of 10 and subcutaneously 40 mg per kg florfenicol was administrated in group I and 2.5 mg per kg tulathromycin was administrated in group II as single dose. The animals were clinically examined before (0 h) and 9 days after the treatment. Also, blood samples were taken and serum haptoglobin and serum amyloid A concentrations were measured before and 9 days after the treatment. It was concluded that although the clinical findings and recovery were not always correlated with serum acute phase proteins levels, florfenicol and tulathromycin can be effective for BRD therapy under field conditions.

Bozkurt, Ayhan/0000-0002-5794-709X; GULBAHAR, MUSTAFA YAVUZ/0000-0001-8268-7659 WOS: 000263479400002 In this Study, a total of 50 male Sprague-Dawley rats were usec for comparative evaluation of therapeutic effects of different probiotics, VSL#3 (a combination of different probiotic bacteria), Lactobacillus acidophilus, and kefir in enterocolitis induced by subcutaneous administration of indomethacin (7.5 mg/kg) twice at 24-hour interval as the experimental Inflammatory bowel disease (IBD) 1-model. Probiotics were orally administered by orogastric gavage on a daily basis for 7 days after induction of IBD, and then rats were euthanased and tissue samples were obtained for macroscopical and histopathological investigations. At the end of the study, it was concluded that therapeutic efficiency of nix probiotic product, which contained different commercial probiotic bacterial strains, was determined in IBD, and therapeutic efficiency of I was also found to be notable in IBD. However, therapeutic activity of Lactobacillus ocidophilus alone was not satisfactory for BD therapy.

WOS: 000251630900008 Trichophytosis is an enzootic skin disease caused by Trichophyton spp. In this study, the beneficial effects of 2 intramuscular injections (10 mL of attenuated T. verrucosum strain (2.5 10(6) agents/mL) at 2 weeks of interval on 9 dermatophytosis affected cows were investigated by evaluation of clinical recovery and measurement of biochemical markers of liver and kidney functions (enzyme AST, ALT and ALP activities and serum BUN, uric acid and creatinine concentrations, respectively) in blood serum collected on days 0 and 14 (before and 6 hours after the intramuscular injection) and on Day 42. Firstly, the presence of virulent T. verrucosum strain in skin lesions of all affected animals was confirmed by isolation and microbiological identification. Total or partial clinical recovery (diminution of the number and size of the skin lesions, reduction of the infected body areas, and disappearance of scurf, scales, hair loss, and keratinisation zones) was observed 4 weeks after the second injection in 66.6% (6/9) and in 33% (3/9) of affected cows respectively. Animals in which clinical recovery was incomplete were the most severely infected before the beginning of treatment. Furthermore, no significant alteration of liver and kidney functions was induced by administration of the attenuated T. verrucosum strain. Consequently, because of the significant reduction of the clinical signs and the absence of side effect, vaccination with attenuated strain of T. verrucosum may be beneficial in the treatment of bovine trichophytosis.

Guvenc, Tolga/0000-0003-1468-3415 WOS: 000254907600039 Clinical signs and necropsy findings were described in a four-year-old female rhesus macaque with diabetes mellitus, resulting from spontaneous amyloidosis. Weakness, polyphagia, polydipsia, and polyuria, which lasted for a few weeks, were determined from anamnesis and clinical investigations. Highly increased serum BUN, AST, ALP levels, glycosuria, and proteinuria was detected in the biochemical analysis. According to these clinical, haematological, and biochemical data, it was thought that the monkey was affected with diabetes mellitus. Despite all efforts to cure the animal, the patient died. Diffuse amyloidosis was detected in the kidney and pancreas at the necropsy and histopathological examinations.

meral, yucel/0000-0001-9099-5061 WOS: 000241012600006 PubMed: 17009812 July 2004, a cow with clinical signs of ovine herpesvirus type-2 infection which is known as sheep associated malignant catarrhal fever (SA-MCF) was reported in Samsun Province in Turkey. Blood samples were collected from the suspected cow, 10 sheep housed with it, and from 150 healthy sheep and 29 healthy cattle randomly selected from different places in Samsun Province. Nested polymerase chain reaction (n-PCR) was used to detect ovine herpesvirus type-2 (OvHV-2) DNA in the suspected cow and competitive-ELISA (c-ELISA) kits were used to detect antibodies against OvHV-2. The suspected cow was found to be n-PCR positive and c-ELISA negative. The serological results were as follows: All 10 (100 %) of sheep housed with the suspected cow and 18 of 29 (62 %) of the randomly selected cattle were found seropositive. All 150 randomly selected healthy sheep were seronegative. The overall percentage of seropositivity was 14.7% (28/190). OvHV-2 DNA was detected in the peripheral blood leucocyte (PBL) samples of the cow and of the 10 sheep housed with the suspected cow.

Cenesiz, Metin/0000-0003-2494-1959; Beyhan, Yunus Emre/0000-0002-1696-4803 WOS: 000345816500003 In this study, clinical and in vivo acaricidal effects of pour-on administered cypermethrin in rabbits with Psoroptes cuniculi were evaluated. Totally 24 rabbits were used in the study. Sixteen rabbits, naturally infested with P. cuniculi were randomly divided into two equal experimental groups and cypermethrin was pour-on administered 5 mg/kg (Group I) and 10 mg/kg (Group II) as a single dose. Also, 8 healthy animals (non-infested with P. cuniculi) exposed only saline were used for the control group. Psoroptic mange was diagnosed and monitored in the experimental groups by otoscopic and microscopic evaluations on Day 0 (pretreatment) and Days 1, 3, 7, 14, and 21 after the treatment. Clinical findings about psoroptic mange were scored, blood cypermethrin concentrations and haematological parameters were determined on the evaluation days. Six rabbits from Group I had P. cuniculi and a statistically important difference was determined between number of infested rabbits of Group I and Group II on Day 21 (p