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La proporción de personas mayores de 60 años en todo el mundo se duplicará entre 2015 y 2050, pasando del 12% al 22%, lo que generará una mayor demanda de servicios en centros gerontológicos. Una de las principales causas de morbimortalidad en los adultos mayores, son las caídas, considerándose unos de los síndromes geriátricos más importantes. El desarrollo de programas de ejercicio físico podrían ser beneficios en la prevención de las caídas. Objetivo: El objetivo general de este trabajo es analizar el efecto de programas de ejercicio físico en relación a la reducción de caídas en personas mayores que residen en centros gerontológicos. Metodología: Para el desarrollo de los objetivos planteados, se elaboró una revisión bibliográfica, elaborando una cadena de búsqueda a través de la inclusión de la estructura PIO en diferentes bases de datos (o metabuscador) (Pubmed, Biblioteca Virtual de la Salud, Cuiden y Biblioteca Cochrane.). Resultados: Los programas de ejercicio físico en el colectivo de adultos mayores institucionalizados como estrategia para la reducción de caídas ha logrado reducir las caías significativamente, aunque no en todos los planes de ejercicio físico son efectivos para tal fin. Discusión: Son varios los puntos que validan la utilidad de un programa de ejercicio físico para obtener beneficios en la tasa de caídas, como son el tipo de programa y la duración del mismo. Conclusiones: Las intervenciones de ejercicio físico en ancianos institucionalizados evidencian que el ejercicio físico puede reducir las caídas, además de minimizar el riesgo de estas y mejorar el rendimiento físico, otorgando una mayor calidad de vida en ese segmento de la población.

[EN]Abstract The aim of the study was to measure the associations between and the evolution of gender awareness, gender-related health knowledge and patient pain legitimation among nursing students. Background Evidence indicates that gender equity skills are still lacking among nurses. Indeed, several studies report gender-biased patient assessment and care, arguing that greater attention should be paid to the gender perspective at university, in order to train nurses who are sensitive to this issue. Recently, certain gender perspective measurement scales have been adapted to the nursing population, offering new opportunities for the educational field. Design A quasi-experimental study was used for this study. Methods This study was conducted in the second semester of the first year of the Nursing Degree run by the University of the Basque Country. A sample of 103 students enrolled in the Anthropology, Ethics and Legislation module completed the Nijmegen Gender Awareness in Medicine Scale, the Pain Legitimation Scale and the Gender Perspective Health Knowledge Scale before and after the second semester, during which part of the syllabus focused on developing gender equity skills. Data were collected between January - April 2022. Results We found positive correlations between gender-related health knowledge and pain legitimation at post-test, and between said knowledge and gender sensitivity at both pre- and post-test (p < 0.05). The repeated measures indicated that traditional expositive teaching did not increase overall scores for gender awareness, gender-related health knowledge or pain legitimation. Conclusions The results suggest that gender-related health knowledge may be a key modifiable factor that leads to enhanced gender awareness in dealings with patients. However, traditional expositive lectures were not enough to produce a robust increase in gender awareness, pain legitimation or gender-related health knowledge levels. The effectiveness of active teachin

Given the increasing prevalence of frailty and its implications for public health, the identification of biomarkers to detect frailty is essential. Sestrin-1 is a protein with a protective role in muscle function. This study aimed to determine whether the serum sestrin-1 concentration differed between frail and non-frail populations and to investigate its association with frailty-related variables in 225 older women and men living in nursing homes (Gipuzkoa, Spain). Serum sestrin-1 concentration was measured by ELISA. Frailty, dependence, anthropometry, physical function, and physical activity were determined by validated tests and tools. The associations between sestrin-1 concentration and the other variables were determined using generalized linear models. The differences between frail and non-frail individuals were analyzed by the Mann–Whitney U-test, and receiver operating characteristic (ROC) curves were constructed to calculate the capability of sestrin-1 to detect frailty. Unexpectedly, frail individuals - according to the Fried Frailty Phenotype or the Clinical Frailty Scale - had higher serum sestrin-1 concentrations than non-frail individuals. Furthermore, the higher serum sestrin-1 concentration was associated with the increased frailty scores and dependence as well as the poorer physical function and the less physical activity. Given the contradictory results regarding serum sestrin-1 and frailty, further investigation is required to propose it as a molecular biomarker of frailty.

[EN]Angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) are two of the main components of the renin-angiotensin system (RAS). Imbalanced RAS showing lower ACE2 has been associated with increased cardiovascular risk, muscular pathologies, sarcopenia, frailty, other age-related pathologies and a poorer health status. However, its role in aging remains unclear. Thus, the aim of this work was to analyze the serum enzymatic activity of ACE and ACE2, the ACE/ACE2 ratio and its association with anthropometric parameters, blood pressure, physical function, dependence and frailty in older people living in nursing homes. This study is a secondary analysis of baseline data from two randomized clinical trials in a population of 228 older individuals living in nursing homes (Spain). Serum ACE and ACE2 enzymatic activities were measured by fluorimetry. Variables linked to cardiovascular risk, physical function, dependence and frailty were measured using validated tests, indexes and scales. Association between ACE, ACE2 serum activities, the ACE/ACE2 ratio and the rest of the quantitative variables were assessed by Pearson's correlations and by partial correlations controlled by age and sex. The association between serum ACE and ACE2 activities, the ACE/ACE2 ratio and frailty scores was analyzed by generalized linear models with and without controlling for sex and age. Differences in enzymatic activities between sexes and between frail and non-frail individuals were analyzed using Student's t-test and general linear models to control analysis by age and sex. We found that higher serum ACE2 activity was associated with a higher body mass index, worse physical function, greater dependence and increased frailty. This association is consistent with the elevation of circulating ACE2 in certain pathological conditions and in line with RAS deregulation in muscular dystrophies. Serum ACE2 activity, in combination with other molecules, could be proposed as a biom

[EN] This study analyzed the effects of an individualized and progressive multicomponent exercise program on blood pressure, cardiorespiratory fitness, and body composition in long-term care residents. This was a single-blind, multicenter, randomized controlled trial performed in 10 long-term care settings and involved 112 participants. Participants were randomly assigned to a control group or an intervention group. The control group participated in routine activities; the intervention group participated in a six-month individualized and progressive multicomponent exercise program focused on strength, balance, and walking recommendations. The intervention group maintained peak VO2, oxygen saturation, and resting heart rate, while the control group showed a significant decrease in peak VO2 and oxygen saturation and an increase in resting heart rate throughout the six-month period. Individualized and progressive multicomponent exercise programs comprising strength, balance, and walking recommendations appear to be effective in preventing cardiorespiratory fitness decline in older adults living in long-term care settings.

Sarrera: Bularreko minbizia, emakumeetan ematen den minbizien artean ohikoena da, munduan zehar dauden emakumeen heriotza-tasa handienaren arrazoia izanik. 2020an 2,2 milioi kasu baino gehiago eman ziren munduan zehar, Espainian, besteak beste 34.088 kasu berri diagnostikatu ziren. Mastektomia tratamenduaren parte izateak, kirurgia ondoren emakumearen bizi-kalitatean eragin nabarmena du, honen beherakada ekarriz. Helburua: Lan honen helburu orokorra da mastektomia burututako bularreko minbizia duten emakumeen bizi-kalitatean, ariketa fisikoa barne hartzen duten erizaintza-zainketek duten eragina aztertzea. Metodología: Ezarritako helburu desberdinak garatzeko, errebisio narratiboa erabili da, dagokion PIO egitura aplikatuz datu-base bakoitzean (Pubmed, BVS, Dialnet eta Cochrane). Informazio gehiago lortu ahal izateko, hainbat web-orri kontsultatu dira. Emaitzak: Emakume hauen bizi-kalitateari dagokionez, ariketa fisikoa estrategia bezala erabiltzeak emaitza esanguratsuak lortu ditu, hala nola, arlo fisiko nahiz afektiboaren beherakadan. Ariketa fisiko mota desberdinak daude. Horrez gain, ariketa fisikoa barne hartzen dituzten zainketetan, erizainaren papera garrantzia handikoa da. Eztabaida: Hainbat dira mastektomia burututako emakumeen bizi-kalitatean ariketa fisikoa barne hartzen dituzten erizaintza-zainketen inguruan sortu diren eztabaidak. Onuren mantenurako, ariketa fisikoarekiko atxikipena bermatzea garrantzitsua litzateke paziente hauetan. Ondorioak: Bizi-kalitatearen beherakada ekiditeko, ariketa fisikoa lantzen jarraitzea gomendatzen da, arlo fisikoa indartzeaz gainera, arlo psikologiko eta soziala salbu mantentzeaz arduratzen da. Onura hauek etorkizunean mantendu ahal izateko, erizainaren laguntzarekin batera, garrantzitsua izango da pazienteak tratamenduarekiko atxikipena eta egokitutako entrenamendua betetzea.

Sarrera: Minbizia gaur egun heriotza gehien eragiten dituen gaixotasuna da. Minbiziaren aurkako tratamenduak albo-ondorio ugari eragiten ditu gaixoarengan, honen bizikalitatea apalduz. Azken urteetan ikuspuntu holistiko eta integrala barne hartzen dituzten terapia osagarrien aplikazioak gora egin du, eta horien artean musikaren erabilera aurki dezakegu. Musika bidezko interbentzioak bizi-kalitatea hobetzeko eraginkorrak direla frogatu da hainbat gaixotasun desberdinen aurrean. Helburua: Musika bidezko interbentzioek paziente onkologikoen bizi-kalitatean zein eragin duten aztertzea da lan honen helburu nagusia. Metodologia: Errebisio narratiboa egin da. Bilaketa bibliografikorako Pubmed, Biblioteca Virtual de la Salud (BVS), Trip Database, Dialnet eta Cuiden datu-baseak erabili dira. Honez gain, informazio gehiago lortzeko asmoz, hainbat erakunderen weborriak kontsultatu dira. Barneratze- eta kanporatze-irizpideak aplikatu ondoren lanerako erabilgarriak izan diren 21 artikulu eta 6 erakunderen web-orrirekin egin da lan. Emaitzak: Musikoterapia musikoterapeutak aplikaturiko musikaren erabilera da, musika-medikuntza osasun-langile batek (erizainak) eskainitako musika entzuteari deritzo. Ikerketa gehienek musikoterapia aztertu dute, baina musika-medikuntza ere artikulu ugaritan izan da aztertua. Musikoterapian erizainak musikoterapeutarekin batera diziplina arteko taldean egin beharko du lan, pazientearen balorazioa eginaz besteak beste. Musika-medikuntzan berriz, erizainak musika saioak gidatu ditzake, bere esku dagoen interbentzioa baita. Hala ere, musika interbentzioen inguruko aurretiazko prestakuntza garrantzitsua izango da. Bai musikoterapiak bai musika-medikuntzak bizikalitatean eragin positiboa dutela ikusi da, baita antsietatea, depresioa eta mina hobetzeari dagokionez ere. Eztabaida: Hainbat eztabaidagai sortu dira musika bidezko interbentzioen eta erizainaren rolaren inguruan. Alde batetik, musika interbentzioen terminologia gatazka eta musika saio mota, irau

Sarrera: Espainian, minbizien intzidentziaren hirugarren postuan, minbizi hematologikoak aurkitzen dira eta hauen artean prebalentzia altuena linfoma eta leuzemia minbizi motak dute. Minbizia dutenen artean aurkitzen den sintomarik ohikoena minbiziarekin lotutako nekea da eta nabarmena da honek, pazienteen bizi-kalitatean eragin handia duela. Honen harira, jarduera fisikoa, minbiziarekin lotuta dagoen neke hori murrizteko tresna lagungarria izan daitekeela aipatu beharra dago. Helburua: Lan honen helburu nagusia linfoma eta leuzemia minbizia duten pazienteen bizi-kalitatean eta nekean erizaintza zainketak barne hartzen dituen jarduera fisikoak duen eragina aztertzea da. Metodologia: Ikerketa galderari erantzuteko errebisio narratibo bat erabili da eta PIO egituraren bitartez artikuluen bilaketa jorratu da. Bilaketa bibliografiko hau egiteko datu-base ezberdinak erabili dira, hala nola, PubMed, Biblioteca Virtual de la Salud, Dialnet, Cuiden eta Cochrane. Bilaketa mugatzeko iragazkien erabilera egin da eta barneratze eta baztertze irizpideak aplikatu dira. Azkenik, web-orrien bitartez lana osatzeko informazioa lortu da. Emaitzak: Erizaintza zainketak barne hartzen dituen jarduera fisikoko programen artean erabilienak aerobikoa eta indar ariketak direla agerikoa da, hauek jorratzerakoan eta zenbait eskalen bitartez ebaluatu ondoren, aztertu da nekearen murrizketa eta bizi-kalitatearen hobekuntza nabaria dela. Linfoma eta leuzemia parekatzerakoan, bi minbizietan nabaria da jarduera fisikoko programen onura, nahiz eta zenbait ikerketetan hobekuntzarik ez lortu. Horrez gain, programa horien bitartez pazienteen funtzio fisikoa, mina, loaren nahasmendua, antsietatea, egoera psiko-sozialaren, etab. hobekuntza nabarmena da. Eztabaida: Ikerketen emaitzak aztertuta, nabarmena da nekea murriztea eta bizi-kalitatea hobetzea lortu duten ikerketak gehiengoak direla. Gainera, aztertu den moduan, erizaintza zainketak barne hartzen dituen jarduera fisikoko programa zehatza dira eragi

Sarrera. Minbiziak gaur egun duen prebalentzia geroz eta altuagoa dela eta, harekin eta haren tratamenduekin lotutako albo-ondorioak pairatzen dituzten pazienteen prebalentzia ere handitzen ari da. Pazienteek sufritzen duten albo-ondorio bat funtzio kognitiboaren narriadura da, paziente hauen bizi-kalitatean okerrera eragiten duelarik. Funtzio kognitiboaren narriadura gutxitzeko ariketa fisikoa interbentzio posible bat izan daiteke. Helburua. Ariketa fisikoak barneratzen duen erizaintzako zainketak paziente onkologikoen funtzio kognitiboan duen eragina aztertzea da errebisio honen helburu nagusia. Helburu zehatzei dagokienez, paziente onkologikoen funtzio kognitiboaren narriadura ezagutzea, narriadura kognitiboa gutxitzeko ariketa fisikoko zein interbentzio diren onuragarriak zehaztea eta minbizi ezberdinetan ematen den narriadura kognitiboan ariketa fisikoaren onurak aztertzea dira. Metodologia. Bilaketa bibliografiko baten bitartez egindako errebisio hau aurrera eramateko, osasun-zientzietako datu base ezberdinak erabili dira: Pubmed, Dialnet eta BVS (Biblioteca Virtual de la Salud). PIO egitura jarraituta bilaketa burutu da, guztira 17 artikulu lortuz. Horrez gain, gaiarekin erlazionatutako organismo ofizialen hiru web-gune ere erabili dira informazio gehigarria lortzeko, Asociación Española Contra el Cáncer, Osasunaren Mundu Erakundea eta Sociedad Española de Oncología Médica. Emaitzak. Minbizia duten pazienteetan ariketa fisikoa egitea eraginkorra da funtzio kognitiboaren narriadura hobetzeko interbentzio bezala; izan ere ikerketetan ondorio positiboak ageri dira alderdi desberdinetan: lan-memorian, memoria bisualean, funtzio exekutiboan, abiadura psikomotorrean eta prozesatze abiaduran besteak beste. Eztabaida. Ariketa fisikoa funtzio kognitiboa hobetzeko baliagarria dela frogatu da, baina ariketa fisikoko mota ezberdinetako ikerketak egin dira orain arte, eta programa optimo bat falta da. Ondorioak. Narriadura kognitiboa tratatzeko ariketa fisiko aerobikoa, i

Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, s-klotho has been proposed as a molecular biomarker of frailty and dependence. This study is a secondary analysis of data from a clinical trial performed in a population of 103 older individuals living in 10 nursing homes in Gipuzkoa (Spain). We aimed to elucidate associations between s-klotho (as measured by enzyme-linked immunosorbent assay) and body composition, physical fitness, and cognition, as well as frailty and dependence (determined using validated tests and scales). In addition, we investigated the association of s-klotho concentration with falls in the six months following the initial assessment. Low s-klotho levels were associated with a lower score in the psychological component of the Tilburg Frailty Indicator, a worse score in the Coding Wechsler Adult Intelligence Scale, and a greater dependence in activities of daily living. Moreover, participants with lower s-klotho concentrations suffered more falls during the 6 months after the assessment. Future translational research should aim to validate klotho's putative role as a biomarker that could identify the risk of aging-related adverse events in clinical practice.

Physical activity (PA) during pregnancy has positive health implications for both mother and child. However, current literature indicates that not all pregnant women meet the international recommendations for PA (at least 150 min/week of moderate-to-vigorous PA). The main objective of this study was to assess PA levels among pregnant women in the city of Donostia-San Sebastian and identify their main sociodemographic predictors. We recruited 441 women in the 12th week of pregnancy from the local public obstetric health services. Women wore an accelerometer for one week during two separate time points (1st and 2nd trimesters of pregnancy) and completed a questionnaire assessing several sociodemographic variables as well as self-reported PA. With this information, we estimated women’s overall PA levels during both time points. The fulfillment of PA recommendations raised up to 77% and 85% during the first and second trimesters, respectively. We found that a higher number of children and a greater preference for exercise positively predicted light-to-moderate PA, being the most consistent predictors. The availability of a greater number of cars negatively predicted moderate-to-vigorous PA.

Background Older adults with cancer experience negative long-term functional effects of both cancer and treatments. Exercise may minimize their age-related and cancer-related functional decline. Methods We conducted a multicentre open-label 12 month randomized clinical trial with two parallel arms including participants aged >= 70 years with lymphoma or carcinoma requiring curative treatment. The study started at the beginning of any phase of cancer treatment (surgery, chemotherapy, or radiotherapy). The usual care group (UCG) received the current national recommendations in physical activity (a guideline without specific counselling). The intervention group (IG) received 1 year phoned physical activity advice individually adapted to physical assessment (twice a month during the first 6 months and then monthly). The primary outcome was the proportion of subjects with a 1 year decreased short physical performance battery (SPPB) score of 1 point or more. Physical, cognitive, and clinical secondary outcomes were also investigated. Results We allocated 301 participants (age 76.7 +/- 5.0, female 60.6%) to each group. At baseline, the median SPPB was 10/12 in both groups. Breast was the most frequent tumour site (35.7%). After 1 year, 14.0% of participants in the UCG and 18.7% in the IG had a decrease in SPPB score of 1 point or more (P = 0.772). At 2 years, there was no difference in SPPB, gait speed, International Physical Activity Questionnaire score, and verbal fluency. Subgroup analyses after 2 years showed a decline in SPPB for 29.8% of UCG and 5.0% of IG breast cancer participants (P = 0.006), in 21.7% of UCG and 6.2% of IG female participants (P = 0.019), and in 24.5% of UCG and 11.1% of IG normal nutritional status participants (P = 0.009). Falls, hospitalization, institutionalization, and death rates were similar in both groups. Conclusions Personalized phoned physical activity advice had not reduced functional decline at 1 year but provided preliminary evidence

406 p., Tesi honek barne hartzen dituen bi proiektuak ausazko entsegu klinikoak izan dira. Helburu nagusia hirugarren adineko pertsona zaurgarrietan (batetik hirugarren adineko egoitzetako pertsonetan eta bestetik minbizia zuten hirugarren adineko pertsonetan) ariketa/jarduera fisikoak duen eragina aztertzea izan da:1) Hirugarren adineko egoitzetako pertsonen ohiko jarduera fisikoa eta egoera fisikoa, hitzezko memoria, bizi-kalitatea eta depresioarekin lotuta daudela behatu dugu. Miostatina kontzentrazio altuagoak behatu ditugu egoera fisiko hobea duten hirugarren adineko pertsonetan. Bestetik, norbanakoari egokitutako eta intentsitate moderatuan buruturiko ariketa fisikoko programa gainbegiratuak eraginkorra dirudi hirugarren adineko egoitzetako pertsonen egoera fisikoa, funtzio kognitiboa eta afektibitate-egoera hobetu edo mantentzeko, eta hauskortasuna eta ondorio kaltegarriak murrizteko.2) Telefonoz helarazi diren eta norbanakoan oinarrituriko jarduera fisikoko gomendioek ez dute gaitasun funtzionalaren galera murriztu urte batera, baina ezberdintasun adierazgarriak lortu dira talde esperimentalaren alde emakumeetan eta bularreko minbizia zuten azpi-taldeetan bi urteren ondoren. Beraz, emaitza hauek minbizia duten hirugarren adineko pertsonetan norbanakoan oinarritu diren eta telefonoz helarazi diren jarduera fisikoko gomendioek duten garrantzia azpimarratzen dute.

BACKGROUND: The purpose of the Aging-ONDUAL-TASK study is to determine if a supervised dual-task program carried out in long-term nursing homes is able to attenuate frailty in a greater extent than the same multicomponent exercise program alone. METHODS: This multicenter randomized controlled trial will include 188 participants who will be randomly allocated to either a multicomponent exercise program or to the same multicomponent program with simultaneous cognitive training (dual-task training). Inclusion criteria are as follows: ≥ 70years, ≥ 50 on the Barthel Index, ≥ 20 on the Mini Examen Cognoscitivo (MEC-35) who are able to stand up and walk independently for 10m. Subjects in the multicomponent group will attend a twice-a-week multicomponent exercise program of 1-h duration per session, consisting of strength and balance exercises. Participants in the dual-task group will perform the same multicomponent exercise program with concurrent individually tailored cognitive tasks. Study assessments will be conducted at baseline and at 3months. The primary outcome measure will be gait speed under dual-task conditions and secondary outcomes will include physical fitness measurements, gait spatiotemporal parameters, cognition and emotional assessments, several frailty scales and objectively measured physical activity. DISCUSSION: The present research will add valuable information to the knowledge around the effects of the dual-task program in long-term nursing home residents, taking altogether physical, cognitive and emotional variables linked to frailty. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry (ANZCTR) with the identifier: ACTRN12618000536268 . Registration date: 11/04/2018.

Background: Few studies have simultaneously examined changes in physical, cognitive and emotional performance throughout the aging process. Methods: Baseline data from an ongoing experimental randomized study were analyzed. Physical activity, handgrip, the Senior Fitness Test, Trail Making Test A, Rey Auditory-Verbal Learning Test, Quality of Life-Alzheimer's Disease Scale (QoL-AD) and the Goldberg Depression Scale were used to assess study participants. Logistic regression models were applied. Trial registration: ACTRN12616001044415 (04/08/2016). Results: The study enrolled 114 participants with a mean age of 84.9 (standard deviation 6.9) years from ten different nursing homes. After adjusting for age, gender and education level, upper limb muscle strength was found to be associated with Rey Auditory-Verbal Learning Test [EXP(B): 1.16, 95% confidence interval (CI): 1.04-1.30] and QoL-AD [EXP(B): 1.18, 95% CI: 1.06-1.31]. Similarly, the number of steps taken per day was negatively associated with the risk of depression according to the Goldberg Depression Scale [EXP(B): 1.14, 95% CI: 1.000-1.003]. Additional analyses suggest that the factors associated with these variables are different according to the need for using an assistive device for walking. In those participants who used it, upper limb muscle strength remained associated with Rey Auditory-Verbal Learning Test [EXP(B): 1.21, 95% CI: 1.01-1.44] and QoL-AD tests [EXP(B): 1.19, 95% CI: 1.02-1.40]. In those individuals who did not need an assistive device for walking, lower limb muscle strength was associated with Rey Auditory-Verbal Learning Test [EXP(B): 1.35, 95% CI: 1.07-1.69], time spent in light physical activity was associated with QoL-AD test [EXP(B): 1.13, 95% CI: 1.00-1.02], and the number of steps walked per day was negatively associated with the risk of depression according to the Goldberg Depression Scale [EXP(B): 1.27, 95% CI: 1.000-1.004]. Conclusions: Muscle strength and physical activity are fa

Background: There is increasing evidence suggesting that cognition and physical frailty interact within a cycle of decline associated with aging which has been called cognitive frailty. Exercise programs have demonstrated to be an effective tool to prevent functional and cognitive decline during aging, but little is known about their potential to restore or maintain functionality in individuals that require long-term nursing care. Besides, WHO has recently highlighted the importance of introducing systematic musculoskeletal health programs for older people living in residential care, as they represent a particularly vulnerable group for the development of noncommunicable diseases. Methods: This is a multicentre randomized controlled trial. 114 participants will be randomly allocated to a usual care group or to an intervention group. Inclusion criteria are as follows: >= 70 years, >= 50 on the Barthel Index, >= 20 on MEC-35 who are capable to stand up and walk independently for 10 m. Subjects in the intervention group will add to the activities scheduled for the control group the participation in a 6 months long multicomponent exercise program designed to improve strength, balance and walking retraining. Study assessments will be conducted at baseline and at 3 and 6 months. The primary outcome is change in function assessed by Short Physical Performance Battery and secondary outcomes include other measurements to assess all together the condition of frailty, which includes functionality, sedentary behaviors, cognitive and emotional status and biological markers. The present study has been approved by the Committee on Ethics in Research of the University of the Basque Country (Humans Committee Code M10/2016/105; Biological Samples Committee Code M30/2016/106). Discussion: Results from this research will show if ageing related functional and cognitive deterioration can be effectively prevented by physical exercise in institutionalized elders. It is expected that the re