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1. Restrictive vs Liberal Blood Transfusions for Patients With Acute Myocardial Infarction and Anemia by Heart Failure Status: An RCT Subgroup Analysis

Author

Ducrocq, Gregory, Cachanado, Marine, Simon, Tabassome, Puymirat, Etienne, Lemesle, Gilles, Lattuca, Benoit, Ariza-Solé, Albert, Silvain, Johanne, Ferrari, Emile, Gonzalez-Juanatey, Jose R., Martínez-Sellés, Manuel, Lermusier, Thibault, Coste, Pierre, Vanzetto, Gerald, Cottin, Yves, Dillinger, Jean G., Calvo, Gonzalo, and Steg, Philippe Gabriel

Published
2024
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2. Economic burden of Cardiac Arrest in Spain: analyzing healthcare costs drivers and treatment strategies cost-effectiveness

Author

Mariano Matilla-García, Paloma Ubeda Molla, Fernando Sánchez Martínez, Albert Ariza-Solé, Rocío Gómez-López, Esteban López de Sá, and Ricard Ferrer

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Cardiac arrest is a major public health issue in Europe. Cardiac arrest seems to be associated with a large socioeconomic burden in terms of resource utilization and health care costs. The aim of this study is the analysis of the economic burden of cardiac arrest in Spain and a cost-effectiveness analysis of the key intervention identified, especially in relation to neurological outcome at discharge. Methods The data comes from the information provided by 115 intensive care and cardiology units from Spain, including information on the care of patients with out-of-hospital cardiac arrest who had a return of spontaneous circulation. The information reported by theses 115 units was collected by a nationwide survey conducted between March and September 2020. Along with number of patients (2631), we also collect information about the structure of the units, temperature management, and prognostication assessments. In this study we analyze the potential association of several factors with neurological outcome at discharge, and the cost associated with the different factors. The cost-effectiveness of using servo-control for temperature management is analyzed by means of a decision model, based on the results of the survey and data collected in the literature, for a one-year and a lifetime time horizon. Results A total of 109 cardiology units provided results on neurological outcome at discharge as evaluated with the cerebral performance category (CPC). The most relevant factor associated with neurological outcome at discharge was ‘servo-control use’, showing a 12.8% decrease in patients with unfavorable neurological outcomes (i.e., CPC3-4 vs. CPC1-2). The total cost per patient (2020 Euros) was €73,502. Only “servo-control use” was associated with an increased mean total cost per hospital. Patients treated with servo-control for temperature management gained in the short term (1 year) an average of 0.039 QALYs over those who were treated with other methods at an increased cost of €70.8, leading to an incremental cost-effectiveness ratio of 1,808 euros. For a lifetime time horizon, the use of servo-control is both more effective and less costly than the alternative. Conclusions Our results suggest the implementation of servo-control techniques in all the units that are involved in managing the cardiac arrest patient from admission until discharge from hospital to minimize the neurological damage to patients and to reduce costs to the health and social security system.

Published
2023
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5. Extended use of dual antiplatelet therapy among older adults with acute coronary syndromes and associated variables: a cohort study

Author

Ariza-Solé, Albert, Mateus-Porta, Gemma, Formiga, Francesc, Garcia-Blas, Sergio, Bonanad, Clara, Núñez-Gil, Iván, Vergara-Uzcategui, Carlos, Díez-Villanueva, Pablo, Bañeras, Jordi, Badia-Molins, Clara, Aboal, Jaime, Carreras-Mora, José, Gabaldón-Pérez, Ana, Parada-Barcia, José Antonio, Martínez-Sellés, Manuel, Comín-Colet, Josep, and Raposeiras-Roubin, Sergio

Published
2023
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7. Clinical profile, management and outcomes of patients with cardiogenic shock undergoing transfer between centers in Spain

Author

Barrionuevo-Sánchez, M. Isabel, Ariza-Solé, Albert, Viana-Tejedor, Ana, del Prado, Náyade, Rosillo, Nicolás, Jorge-Pérez, Pablo, Sánchez-Salado, José Carlos, Lorente, Victòria, Alegre, Oriol, Llaó, Isaac, Martín-Asenjo, Roberto, Bernal, José Luis, Fernández-Pérez, Cristina, Corbí-Pascual, Miguel, Pascual, Júlia, Marcos, Marta, de la Cuerda, Francisco, Carmona, Jesús, Comin-Colet, Josep, and Elola, Francisco Javier

Published
2024
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8. Perfil clínico, abordaje y pronóstico del paciente con shock cardiogénico sometido a traslado interhospitalario en España

Author

Barrionuevo-Sánchez, M. Isabel, Ariza-Solé, Albert, Viana-Tejedor, Ana, del Prado, Náyade, Rosillo, Nicolás, Jorge-Pérez, Pablo, Sánchez-Salado, José Carlos, Lorente, Victòria, Alegre, Oriol, Llaó, Isaac, Martín-Asenjo, Roberto, Bernal, José Luis, Fernández-Pérez, Cristina, Corbí-Pascual, Miguel, Pascual, Júlia, Marcos, Marta, de la Cuerda, Francisco, Carmona, Jesús, Comin-Colet, Josep, and Elola, Francisco Javier

Published
2024
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9. Geriatric conditions and invasive management in frail patients with NSTEMI. A subgroup analysis of a randomized clinical trial

Author

Sanchis, Juan, Bueno, Héctor, García-Blas, Sergio, Gómez-Hospital, Joan A., Martí, David, Martínez-Sellés, Manuel, Domínguez-Pérez, Laura, Díez-Villanueva, Pablo, Barrabés, José A., Marín, Francisco, Villa, Adolfo, Sanmartín, Marcelo, Llibre, Cinta, Sionis, Alessandro, Carol, Antoni, Valero, Ernesto, Calvo, Elena, Morales, María José, Elízaga, Jaime, Gómez, Iván, Alfonso, Fernando, García del Blanco, Bruno, Formiga, Francesc, Núñez, Eduardo, Núñez, Julio, and Ariza-Solé, Albert

Published
2024
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10. Efficacy and safety of bempedoic acid in acute coronary syndrome. Design of the clinical trial ES-BempeDACS

Author

Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Pérez Rivera, José Ángel, Jorge Pérez, Pablo, Ayesta López, Ana, Viana Tejedor, Ana, Corbí Pascual, Miguel José, Carrasquer, Anna, Jiménez Méndez, César, González Cambeiro, Cristina, Uribarri González, Aitor, Bonanad Lozano, Clara, Marcos Mangas, Marta, Merino-Merino, Ana, Sánchez-Corral, Ester, Santos-Sánchez, Isabel, Aguilar-Iglesias, Lara, Alen, Alberto, Rozado Castaño, José, Mínguez de la Guía, Ester, López Vázquez, Macarena, Salmerón Martínez, Francisco Manuel, Avivar Sáez, Ylènia, Villar Ruiz, Alberto, Panera de la Mano, José Antonio, García García, Marina Teresa, Pérez-Asensio, Ana, Bompart, Daznia, Zaharia, Georgiana, and Ariza-Solé, Albert

Published
2024
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11. Eficacia y seguridad del ácido bempedoico en el síndrome coronario agudo. Diseño del ensayo clínico ES-BempeDACS

Author

Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Pérez Rivera, José Ángel, Jorge Pérez, Pablo, Ayesta López, Ana, Viana Tejedor, Ana, Corbí Pascual, Miguel José, Carrasquer, Anna, Jiménez Méndez, César, González Cambeiro, Cristina, Uribarri González, Aitor, Bonanad Lozano, Clara, Marcos Mangas, Marta, Merino-Merino, Ana, Sánchez-Corral, Ester, Santos-Sánchez, Isabel, Aguilar-Iglesias, Lara, Alen, Alberto, Rozado Castaño, José, Mínguez de la Guía, Ester, López Vázquez, Macarena, Salmerón Martínez, Francisco Manuel, Avivar Sáez, Ylènia, Villar Ruiz, Alberto, Panera de la Mano, José Antonio, García García, Marina Teresa, Pérez-Asensio, Ana, Bompart, Daznia, Zaharia, Georgiana, and Ariza-Solé, Albert

Published
2024
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13. Clinical profile and prognosis of young patients with ST-elevation myocardial infarction managed by the emergency-intervention Codi IAM network

Author

Flores-Umanzor, Eduardo, Cepas-Guillén, Pedro, Freixa, Xavier, Regueiro, Ander, Tizón-Marcos, Helena, Brugaletta, Salvatore, Ariza-Solé, Albert, Calvo, Margarita, Forado, Ilana, Carrillo, Xavier, Cárdenas, Mérida, Rojas, Sergio Giovanny, Muñoz, Juan Francisco, García-Picart, Joan, Lidón, Rosa María, Sabaté, Manel, Masotti, Mónica, and Roqué, Mercè

Published
2023
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14. Perfil clínico y pronóstico de pacientes jóvenes con infarto agudo de miocardio con elevación del segmento ST tratados en la red Codi IAM

Author

Flores-Umanzor, Eduardo, Cepas-Guillén, Pedro, Freixa, Xavier, Regueiro, Ander, Tizón-Marcos, Helena, Brugaletta, Salvatore, Ariza-Solé, Albert, Calvo, Margarita, Forado, Ilana, Carrillo, Xavier, Cárdenas, Mérida, Rojas, Sergio Giovanny, Muñoz, Juan Francisco, García-Picart, Joan, Lidón, Rosa María, Sabaté, Manel, Masotti, Mónica, and Roqué, Mercè

Published
2023
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15. Extended use of dual antiplatelet therapy among older adults with acute coronary syndromes and associated variables: a cohort study

Author

Albert Ariza-Solé, Gemma Mateus-Porta, Francesc Formiga, Sergio Garcia-Blas, Clara Bonanad, Iván Núñez-Gil, Carlos Vergara-Uzcategui, Pablo Díez-Villanueva, Jordi Bañeras, Clara Badia-Molins, Jaime Aboal, José Carreras-Mora, Ana Gabaldón-Pérez, José Antonio Parada-Barcia, Manuel Martínez-Sellés, Josep Comín-Colet, and Sergio Raposeiras-Roubin

Subjects
Elderly, Acute coronary syndromes, Dual antiplatelet therapy, Bleeding risk, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract Background Current guidelines recommend extending the use of dual antiplatelet therapy (DAPT) beyond 1 year in patients with an acute coronary syndrome (ACS) and a high risk of ischaemia and low risk of bleeding. No data exist about the implementation of this strategy in older adults from routine clinical practice. Methods We conducted a Spanish multicentre, retrospective, observational registry-based study that included patients with ACS but no thrombotic or bleeding events during the first year of DAPT after discharge and no indication for oral anticoagulants. High bleeding risk was defined according to the Academic Research Consortium definition. We assessed the proportion of cases of extended DAPT among patients 65 ≥ years that went beyond 1 year after hospitalisation for ACS and the variables associated with the strategy. Results We found that 48.1% (928/1,928) of patients were aged ≥ 65 years. DAPT was continued beyond 1 year in 32.1% (298/928) of patients ≥ 65; which was a similar proportion as with their younger counterparts. There was no significant correlation between a high bleeding risk and DAPT duration. Contrastingly, there was a strong correlation between the extent of coronary disease and DAPT duration (p

Published
2023
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16. Prognosis of cardiogenic shock secondary to culprit left main coronary artery lesion‐related myocardial infarction

Author

Francisco Galván‐Román, Ignacio Fernández‐Herrero, Albert Ariza‐Solé, José Carlos Sánchez‐Salado, Elena Puerto, Victòria Lorente, Josep Gómez‐Lara, Roberto Martín‐Asenjo, Joan A. Gómez‐Hospital, and Josep Comín‐Colet

Subjects
Acute myocardial infarction, Cardiogenic shock, Left main coronary artery, Percutaneous coronary intervention, Mechanical circulatory support, Heart transplantation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims This study aimed to assess, in patients with cardiogenic shock secondary to unprotected left main coronary artery‐related myocardial infarction (ULMCA‐related AMICS), the incidence and predictors of no recovery of left ventricular function during the admission. Methods and results This was an observational study conducted at two tertiary care centres (2012–20). The main outcome measured was death or requirement for heart transplantation (HT) or left ventricular assist devices (LVAD) during the admission. A total of 70 patients were included. Percutaneous coronary intervention (PCI) was successful in 53/70 patients (75.7%). The combined endpoint of death or requirement of HT or LVAD during the admission occurred in 41/70 patients (58.6%). The highest incidence of the primary endpoint was observed among patients with profound shock and occluded left main coronary artery (LMCA) (20/23, 87%, P

Published
2023
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17. Optimal medical therapy improves outcomes in patients with diabetes mellitus and acute myocardial infarction

Author

Zhang, Dongfeng, Gao, Hai, Song, Xiantao, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Paulo Simao Henriques, Jose, D'Ascenzo, Fabrizio, Saucedo, Jorge, Ramón González-Juanatey, José, Wilton, Stephen B., Kikkert, Wouter J., Nuñez-Gil, Iván, Ariza-Sole, Albert, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Moretti, Claudio, Huczek, Zenon, Nie, Shaoping, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, Southern, Danielle, and Kalpak, Oliver

Published
2023
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18. Antithrombotic Strategy in Secondary Prevention for High-Risk Patients with Previous Acute Coronary Syndrome: Overlap between the PEGASUS Eligibility and the COMPASS Eligibility in a Large Multicenter Registry

Author

Millesimo, Michele, Elia, Edoardo, Marengo, Giorgio, De Filippo, Ovidio, Raposeiras-Roubin, Sergio, Wańha, Wojciech, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Liebetrau, Christoph, Manzano-Fernández, Sergio, Iannaccone, Mario, Henriques, Jose Paulo Simao, Templin, Christian, Wilton, Stephen B., Velicki, Lazar, Xanthopoulou, Ioanna, Correia, Luis, Cerrato, Enrico, Rognoni, Andrea, Nuñez-Gil, Iván, Song, Xiantao, Kawaji, Tetsuma, Quadri, Giorgio, Huczek, Zenon, Paz, Rafael Cobas, Juanatey, José Ramón González, Nie, Shao-Ping, Kawashiri, Masa-aki, Dominguez-Rodriguez, Alberto, Conrotto, Federico, D’Ascenzo, Fabrizio, and De Ferrari, Gaetano Maria

Published
2023
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19. Impact of shock aetiology and hospital characteristics on the clinical profile, management and prognosis of patients with non ACS-related cardiogenic shock

Author

M Isabel Barrionuevo-Sánchez, Albert Ariza-Solé, Náyade del Prado, María García, José Carlos Sánchez-Salado, Victòria Lorente, Oriol Alegre, Isaac Llaó, José Luis Bernal, Cristina Fernández-Pérez, Francisco Galván-Román, Francisco de la Cuerda, Júlia Pascual, Angel Cequier, Josep Comin-Colet, and Francisco Javier Elola

Subjects
Non ACS-related Cardiogenic Shock, Prognosis, Intensive Cardiac Care Unit, Management, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: A significant proportion of cases of cardiogenic shock (CS) are due aetiologies other than acute coronary syndromes (non ACS-CS). We assessed differences regarding clinical profile, management, and prognosis according to the cause of CS among nonselected patients with CS from a large nationwide database. Methods: We performed an observational study including patients admitted from the hospitals of the Spanish National Health System (SNHS) with a principal or secondary diagnosis code of CS (2016-2019). Data were obtained from the Minimum Basic Data Set (MBDS). Hospitals were classified according to the availability of cardiology related resources, as well as the availability of Intensive Cardiac Care Unit (ICCU). Results: A total of 10,826 episodes of CS were included, of whom 5,495 (50.8%) were non-ACS related. Non ACS-CS patients were younger (71.5 vs. 72.4 years) and had a lower burden of arteriosclerosis-related comorbidities. Non ACS-CS cases underwent less often invasive procedures and presented lower in-hospital mortality (57.1% vs. 61%,p

Published
2023
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20. Código shock cardiogénico 2023. Documento de expertos para una organización multidisciplinaria que permita una atención de calidad

Author

Martínez-Sellés, Manuel, Hernández-Pérez, Francisco José, Uribarri, Aitor, Martín Villén, Luis, Zapata, Luis, Alonso, Joaquín J., Amat-Santos, Ignacio J., Ariza-Solé, Albert, Barrabés, José A., Barrio, José María, Canteli, Ángela, Alonso-Fernández-Gatta, Marta, Corbí Pascual, Miguel J., Díaz, Domingo, Crespo-Leiro, María G., de la Torre-Hernández, Jose María, Ferrera, Carlos, García González, Martín J., García-Carreño, Jorge, García-Guereta, Luis, García Quintana, Antonio, Jorge Pérez, Pablo, González-Juanatey, José R., López de Sá, Esteban, Sánchez, Pedro Luis, Monteagudo, María, Palomo López, Nora, Reyes, Guillermo, Rosell, Fernando, Solla Buceta, Miguel Antonio, Segovia-Cubero, Javier, Sionis Green, Alessandro, Stepanenko, Alexander, Iglesias Álvarez, Diego, Viana Tejedor, Ana, Voces, Roberto, Fuset Cabanes, María Paz, Gimeno Costa, José Ricardo, Díaz, José, and Fernández-Avilés, Francisco

Published
2023
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21. Coronariografía urgente en los pacientes con parada cardiaca extrahospitalaria sin elevación del segmento ST. Ensayo clínico COUPE

Author

Viana-Tejedor, Ana, Andrea-Riba, Rut, Scardino, Claudia, Ariza-Solé, Albert, Bañeras, Jordi, García-García, Cosme, Jiménez Mena, Manuel, Vila, Monserrat, Martínez-Sellés, Manuel, Pastor, Gemma, García Acuña, José María, Loma-Osorio, Pablo, García Rubira, Juan Carlos, Jorge Pérez, Pablo, Pastor, Pablo, Ferrera, Carlos, Noriega, Francisco J., Pérez Macías, Natalia, Fernández-Ortiz, Antonio, and Pérez-Villacastín, Julián

Published
2023
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22. Impacto de la movilización en pacientes portadores de soporte circulatorio mecánico de corta duración tipo Levitronix® CentriMag como puente a trasplante cardíaco

Author

Chicano-Corrales, A., Bañeras-Rius, J., de Frutos, F., Sánchez-Salado, J.C., Ariza-Solé, A., Blasco-Lucas, A., Sbraga, F., Díez-López, C., Calvo-Barriuso, E., Castillo García, J., Molina-Mazón, C.S., López-López, A., Tinoco-Amorós, I., Abellán-García, A., and González-Costello, J.

Published
2023
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24. Coronavirus: la emergencia geriátrica de 2020. Documento conjunto de la Sección de Cardiología Geriátrica de la Sociedad Española de Cardiología y la Sociedad Española de Geriatría y Gerontología

Author

Bonanad, C., García-Blas, S., Díez-Villanueva, P., Ayesta, A., Sanchis Forés, J., Ariza-Solé, A., Martínez-Sellés, M., Tarazona-Santabalbina, F.J., Vidán-Austiz, M., Formiga, F., Bonanad, Clara, García-Blas, Sergio, Tarazona-Santabalbina, Francisco José, Díez-Villanueva, Pablo, Ayesta, Ana, Sanchis Forés, Juan, Vidán-Austiz, María Teresa, Formiga, Francesc, Ariza-Solé, Albert, and Martínez-Sellés, Manuel

Published
2020
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25. Ischemic-hemorrhagic balance in diabetic and non-diabetic patients after acute coronary syndrome

Author

Domínguez-Rodríguez, Luis Manuel, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Cespón-Fernández, María, Melendo-Viu, María, D’Ascenzo, Fabrizio, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Quadri, Giorgio, Rognoni, Andrea, Boccuzzi, Giacome, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Flores-Blanco, Pedro, Garay, Alberto, Varbella, Ferdinando, Tommassini, Francesco, Gallo, Diego, Morbiducci, Umberto, Domínguez-Rodríguez, Alberto, Valdés, Mariano, Cequier, Ángel, Gaita, Fiorenzo, Alexopoulos, Dimitrios, and Íñiguez-Romo, Andrés

Published
2022
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26. The impact of sex and physical performance on long-term mortality in older patients with myocardial infarction

Author

Tonet, Elisabetta, Ariza-Solé, Albert, Serenelli, Matteo, Formiga, Francesc, Sanchis, Juan, Pavasini, Rita, Diez-Villanueva, Pablo, Vitali, Francesco, Bonanad, Clara, Grazzi, Giovanni, Carol, Antoni, Chiaranda, Giorgio, Pompei, Graziella, Cardelli, Laura Sofia, Caglioni, Serena, Gibiino, Federico, Volpato, Stefano, and Campo, Gianluca

Published
2022
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30. The impact of sex and physical performance on long-term mortality in older patients with myocardial infarction

Author

Elisabetta Tonet, Albert Ariza-Solé, Matteo Serenelli, Francesc Formiga, Juan Sanchis, Rita Pavasini, Pablo Diez-Villanueva, Francesco Vitali, Clara Bonanad, Giovanni Grazzi, Antoni Carol, Giorgio Chiaranda, Graziella Pompei, Laura Sofia Cardelli, Serena Caglioni, Federico Gibiino, Stefano Volpato, and Gianluca Campo

Subjects
Acute coronary syndrome, Sex, Physical performance, Elderly, Mortality, Medicine
Abstract

Abstract Background Sex influences outcome of patients with acute coronary syndrome (ACS). If there is a relationship between sex and physical performance is unknown. Methods The analysis is based on older (≥70 years) ACS patients included in the FRASER, HULK, and LONGEVO SCA prospective studies. Physical performance was assessed by Short Physical Performance Battery (SPPB). The primary outcome was all-cause mortality. Results The study included 1388 patients, and 441 (32%) were women. At presentation, women were older and more compromised than men. After a median follow-up of 998 [730–1168] days, all-cause death occurred in 334 (24.1%) patients. At univariate analysis, female sex was related to increased risk of death. After adjustments for confounding factors, female sex was no longer associated with mortality. Women showed poor physical performance compared with men (p < 0.001). SPPB values emerged as an independent predictor of death. Including clinical features and SPPB in the multivariable model, we observed a paradigm shift in the prognostic role of female sex that becomes a protective factor (HR 0.73, 95% CI 0.56–0.96). Sex and physical performance showed a significant interaction (p = 0.03). For lower SPPB values (poor physical performance), sex-related changes in mortality were not recorded, while in patients with higher SPPB values (preserved physical performance), female sex was associated with better survival. Conclusions Two key findings emerged from the present real-life cohort of older ACS patients: (i) physical performance strongly influences long-term mortality; (ii) women with preserved physical performance have a better outcome compared to men. Trial registration www.clinicaltrials.gov NCT02386124 and NCT03021044

Published
2022
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32. Invasive Treatment Strategy in Adults With Frailty and Non–ST-Segment Elevation Myocardial Infarction

Author

Sanchis, Juan, primary, Bueno, Héctor, additional, García-Blas, Sergio, additional, Alegre, Oriol, additional, Martí, David, additional, Martínez-Sellés, Manuel, additional, Domínguez-Pérez, Laura, additional, Díez-Villanueva, Pablo, additional, Barrabés, Jose A., additional, Marín, Francisco, additional, Villa, Adolfo, additional, Sanmartín, Marcelo, additional, Llibre, Cinta, additional, Sionís, Alessandro, additional, Carol, Antoni, additional, Fernández-Cisnal, Agustín, additional, Calvo, Elena, additional, Morales, María José, additional, Elízaga, Jaime, additional, Gómez, Iván, additional, Alfonso, Fernando, additional, García del Blanco, Bruno, additional, Formiga, Francesc, additional, Núñez, Eduardo, additional, Núñez, Julio, additional, and Ariza-Solé, Albert, additional

Published
2024
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35. Clinical picture, outcomes and predictors of relapse in eosinophilia-associated coronary vasospasm: data from a European multicentric study

Author

Huang, Florent, primary, Khellaf, Lucas Rémi, additional, Lefèvre, Guillaume, additional, Berti, Alvise, additional, d’Humières, Thomas, additional, Sionis, Alessandro, additional, Ariza Solé, Albert, additional, Bello, Federica, additional, Bermeo Garrido, Juan Andres, additional, Crickx, Etienne, additional, Delvino, Paolo, additional, Emmi, Giacomo, additional, Gaillet, Antoine, additional, Garcia, Gilles, additional, Gavand, Pierre-Edouard, additional, George, Jean-Louis, additional, Gilles, Floriane, additional, Golden, Cécile, additional, de Groote, Pascal, additional, Guffroy, Aurélien, additional, Martis, Nihal, additional, Monti, Sara, additional, Mourlanette, Pierre, additional, Pineton de Chambrun, Marc, additional, Prunier, Fabrice, additional, Regola, Francesca, additional, Seret, Gabriel, additional, Terrier, Benjamin, additional, Tréfond, Ludovic, additional, Souteyrand, Géraud, additional, Varenne, Olivier, additional, Zilio, Filippo, additional, Haziza, Franck, additional, Benamer, Hakim, additional, Kahn, Jean-Emmanuel, additional, Vallée, Alexandre, additional, and Groh, Matthieu, additional

Published
2024
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36. Tendencias temporales en comunicación interventricular posinfarto: resultados del registro CIVIAM

Author

Sánchez Vega, Juan Diego, Alonso Salinas, Gonzalo Luis, Viéitez Flórez, José María, Ariza Solé, Albert, López de Sá, Esteban, Sanz Ruiz, Ricardo, Burgos Palacios, Virginia, Raposeiras-Roubín, Sergio, Gómez Varela, Susana, Sanchis, Juan, Silva Melchor, Lorenzo, Martínez-Seara, Xurxo, Malagón López, Lorena, Zamorano Gómez, José Luis, and Sanmartín Fernández, Marcelo

Published
2021
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37. Carga de comorbilidad y beneficio de la revascularización en ancianos con síndrome coronario agudo

Author

Sanchis, Juan, García Acuña, Jose María, Raposeiras, Sergio, Barrabés, Jose A., Cordero, Alberto, Martínez-Sellés, Manuel, Bardají, Alfredo, Díez-Villanueva, Pablo, Marín, Francisco, Ruiz-Nodar, Juan M., Vicente-Ibarra, Nuria, Alonso Salinas, Gonzalo L., Rigueiro, Pedro, Abu-Assi, Emad, Formiga, Frances, Núñez, Julio, Núñez, Eduardo, and Ariza-Solé, Albert

Published
2021
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39. Sex differences in the impact of frailty in elderly outpatients with heart failure

Author

Pablo Díez-Villanueva, César Jiménez-Méndez, Clara Bonanad, Carolina Ortiz-Cortés, Eduardo Barge-Caballero, Josebe Goirigolzarri, Alberto Esteban-Fernández, Angel Pérez-Rivera, Marta Cobo, Ancor Sanz-García, Francesc Formiga, Albert Ariza-Solé, Manuel Martínez-Sellés, and Fernando Alfonso

Subjects
frailty, heart failure, elderly, sex, prognosis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

IntroductionFrailty is common among patients with heart failure (HF). Our aim was to address the role of frailty in the management and prognosis of elderly men and women with HF.Methods and resultsProspective multicenter registry that included 499 HF outpatients ≥75 years old. Mean age was 81.4 ± 4.3 years, and 193 (38%) were women. Compared with men, women were older (81.9 ± 4.3 vs. 81.0 ± 4.2 years, p = 0.03) and had higher left ventricular ejection fraction (46 vs. 40%, p < 0.001) and less ischemic heart disease (30 vs. 57%, p < 0.001). Women had a higher prevalence of frailty (22 vs. 10% with Clinical Frailty Scale, 34 vs. 15% with FRAIL, and 67% vs. 46% with the mobility visual scale, all p-values < 0.001) and other geriatric conditions (Barthel index ≤90: 14.9 vs. 6.2%, p = 0.003; malnutrition according to Mini Nutritional Assessment Short Formulary ≤11: 55% vs. 42%, p = 0.007; Pfeiffer cognitive test's errors: 1.6 ± 1.7 vs. 1.0 ± 1.6, p < 0.001; depression according to Yesavage test; p < 0.001) and lower comorbidity (Charlson index ≥4: 14.1% vs. 22.1%, p = 0.038). Women also showed worse self-reported quality of life (6.5 ± 2.1 vs. 6.9 ± 1.9, on a scale from 0 to 10, p = 0.012). In the univariate analysis, frailty was an independent predictor of mortality in men [Hazard ratio (HR) 3.18, 95% confidence interval (CI) 1.29–7.83, p = 0.012; HR 4.53, 95% CI 2.08–9.89, p < 0.001; and HR 2.61, 95% CI 1.23–5.43, p = 0.010, according to FRAIL, Clinical Frailty Scale, and visual mobility scale, respectively], but not in women. In the multivariable analysis, frailty identified by the visual mobility scale was an independent predictor of mortality (HR 1.95, 95% CI 1.04–3.67, p = 0.03) and mortality/readmission (HR 2.06, 95% CI 1.05–4.04, p = 0.03) in men.ConclusionsIn elderly outpatients with HF frailty is more common in women than in men. However, frailty is only associated with mortality in men.

Published
2022
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40. Sex differences in the management of patients with acute coronary syndrome: A population-based ecological cross-sectional study in Spain

Author

Ruiz-Nodar, Juan Miguel, Ferreiro, José Luis, Ribera, Aida, Marsal, Josep Ramón, García Acuña, José María, Agra Bermejo, Rosa, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Cordero, Alberto, Bertomeu-González, Vicente, Chacón Piñero, Antonio, Nogales-Asensio, Juan Manuel, Marín Ortuño, Francisco, Esteve-Pastor, María Asunción, Sánchez, Pedro Luis, Fernández-Avilés, Francisco, Gómez Polo, Juan Carlos, Viana Tejedor, Ana, Ariza Solé, Albert, Sanchis, Juan, Martí Sánchez, David, Carballeira Puentes, Damaris, Almendro-Delia, Manuel, Santás-Álvarez, Melisa, Valls-Serral, Amparo, Lozano, Íñigo, Anguita, Manuel, and Cequier, Ángel

Published
2021
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41. International Prospective Registry of Acute Coronary Syndromes in Patients With COVID-19

Author

Kite, Thomas A., Ludman, Peter F., Gale, Chris P., Wu, Jianhua, Caixeta, Adriano, Mansourati, Jacques, Sabate, Manel, Jimenez-Quevedo, Pilar, Candilio, Luciano, Sadeghipour, Parham, Iniesta, Angel M., Hoole, Stephen P., Palmer, Nick, Ariza-Solé, Albert, Namitokov, Alim, Escutia-Cuevas, Hector H., Vincent, Flavien, Tica, Otilia, Ngunga, Mzee, Meray, Imad, Morrow, Andrew, Arefin, Md Minhaj, Lindsay, Steven, Kazamel, Ghada, Sharma, Vinoda, Saad, Aly, Sinagra, Gianfranco, Sanchez, Federico Ariel, Roik, Marek, Savonitto, Stefano, Vavlukis, Marija, Sangaraju, Shankar, Malik, Iqbal S., Kean, Sharon, Curzen, Nick, Berry, Colin, Stone, Gregg W., Gersh, Bernard J., and Gershlick, Anthony H.

Published
2021
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42. Non-ST Elevation Myocardial Infarction in the Elderly. Antithrombotic Therapy and Beyond

Author

Pablo Díez-Villanueva, César Jiménez-Méndez, José Luis Ferreiro, Pedro Cepas-Guillén, Clara Bonanad, Sergio García-Blas, Albert Ariza-Solé, Juan Sanchís, and Manuel Martínez-Sellés

Subjects
elderly, acute coronary syndrome, non-st segment elevation myocardial infarction, antithrombotic therapy, frailty, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Non-ST segment elevation myocardial infarction (NSTEMI) is the most frequent type of acute coronary syndrome in the elderly. Antithrombotic therapy is the cornerstone of pharmacological therapy in the setting of an acute ischemic event, a clinical scenario in which thrombotic and bleeding risks ought to be considered, particularly in older patients. In this article, specific aspects of antithrombotic therapy in elderly patients with NSTEMI are reviewed, including pharmacokinetic and pharmacodynamic characteristics and different clinical situations. The role of frailty and other common geriatric conditions, that are associated with worse prognosis in elderly patients with cardiovascular disease, is also addressed.

Published
2023
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44. Clinical picture, management and risk stratification in patients with cardiogenic shock: does gender matter?

Author

Collado Lledó, Elena, Noriega Sanz, Francisco Javier, Viana Tejedor, Ana Teresa, Ariza Solé, Albert, Collado Lledó, Elena, Noriega Sanz, Francisco Javier, Viana Tejedor, Ana Teresa, and Ariza Solé, Albert

Abstract

El reconocimiento precoz y la estratificación del riesgo son cruciales en el shock cardiogénico (SC). Se ha descrito una menor adherencia a las recomendaciones en mujeres con enfermedades cardiovasculares. Existe poca información sobre las disparidades en el cuadro clínico, el manejo y el rendimiento de las herramientas de estratificación del riesgo en función del sexo en pacientes con SC. Se utilizaron datos del registro multicéntrico Red-Shock. Se incluyeron todos los pacientes consecutivos con SC. Se calcularon las puntuaciones de riesgo de acuerdo a las escalas CardShock e IABP-SHOCK II. El criterio de valoración principal fue la mortalidad intrahospitalaria. La capacidad discriminativa de ambas escalas en función del sexo se evaluó mediante regresión logística binaria, calculando curvas Receiver operating characteristic (ROC) y la correspondiente área bajo la curva (AUC). Resultados: Se incluyeron 793 pacientes, de los cuales 222 (28%) eran mujeres. Las mujeres eran significativamente mayores y presentaban una menor proporción de enfermedad pulmonar obstructiva crónica e infarto de miocardio previo. El SC se relacionó con menor frecuencia con los síndromes coronarios agudos (SCA) en las mujeres. El uso de fármacos vasoactivos, terapia renal sustitutiva, ventilación invasiva, hipotermia terapéutica y soporte circulatorio mecánico fue similar entre ambos grupos. La mortalidad intrahospitalaria fue de 346/793 (43,6%). La mortalidad no fue significativamente diferente según el sexo (p = 0,194). La puntuación de riesgo Cardshock mostró una buena capacidad para predecir la mortalidad intrahospitalaria tanto en hombres (AUC 0,69) como en mujeres (AUC 0,735). Asimismo, el IABP-SHOCK II predijo con éxito la mortalidad intrahospitalaria en ambos grupos (hombre: AUC 0,693; mujeres: AUC 0,722). Conclusiones: No se observaron diferencias significativas en cuanto al manejo y la mortalidad intrahospitalaria en función del sexo. Tanto la puntuación de riesgo CardShock como la, Background: Early recognition and risk stratification are crucial in cardiogenic shock (CS). A lower adherence to recommendations has been described in women with cardiovascular diseases. Little information exists about disparities in clinical picture, management and performance of risk stratification tools according to gender in patients with CS. Methods: Data from the multicenter Red-Shock registry were used. All consecutive patients with CS were included. Both CardShock and IABP-SHOCK II risk scores were calculated. The primary end-point was in-hospital mortality. The discriminative ability of both scores according to gender was assessed by binary logistic regression, calculating Receiver operating characteristic (ROC) curves and the corresponding area under the curve (AUC). Results: A total of 793 patients were included, of whom 222 (28%) were female. Women were significantly older and had a lower proportion of chronic obstructive pulmonary disease and prior myocardial infarction. CS was less often related to acute coronary syndromes (ACS) in women. The use of vasoactive drugs, renal replacement therapy, invasive ventilation, therapeutic hypothermia and mechanical circulatory support was similar between both groups. In-hospital mortality was 346/793 (43.6%). Mortality was not significantly different according to gender (p = 0.194). Cardshock risk score showed a good ability for predicting in-hospital mortality both in man (AUC 0.69) and women (AUC 0.735). Likewise, the IABP-II successfully predicted in-hospital mortality in both groups (man: AUC 0.693; women: AUC 0.722). Conclusions: No significant differences were observed regarding management and in-hospital mortality according to gender. Both the CardShock and IABP-II risk scores depicted a good ability for predicting mortality also in women with CS., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

45. Corrigendum: Dynamics of Emergency Cardiovascular Hospital Admissions and In-Hospital Mortality During the COVID-19 Pandemic: Time Series Analysis and Impact of Socioeconomic Factors

Author

Claudia Álvarez-Martín, Aida Ribera, Josep Ramon Marsal, Albert Ariza-Solé, Santiago Pérez-Hoyos, Gerard Oristrell, Toni Soriano-Colomé, Rafael Romaguera, Jose Ignacio Pijoan, Rosa M. Lidón, Josepa Mauri, and Ignacio Ferreira-González

Subjects
COVID-19, acute coronary syndrome, myocardial infarction, heart failure, time-series, Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2022
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46. 'Impact of age on management and prognosis of resuscitated sudden cardiac death patients'

Author

Jordi Sans Roselló, Maria Vidal-Burdeus, Pablo Loma-Osorio, Alexandra Pons Riverola, Gil Bonet Pineda, Nabil El Ouaddi, Jaime Aboal, Albert Ariza Solé, Claudia Scardino, Cosme García-García, Estefanía Fernández-Peregrina, and Alessandro Sionis

Subjects
Sudden cardiac death, Elderly patients, Neurological outcomes, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Sudden cardiac death (SCD) has a great impact on healthcare due to cardiologic and neurological complications. Admissions of elderly people in Cardiology Intensive Care Units have increased. We assessed the impact of age in presentation, therapeutic management and in vital and neurological prognosis of SCD patients. Methods: We carried out a retrospective, observational, multicenter registry of patients who were admitted with a SCD in 5 tertiary hospitals from January 2013 to December 2020. We divided our cohort into two groups (patients 1 at admission, time to CPR initiation > 5 min, time to ROSC > 20 min and lactate > 2 mmol/L were independent predictors for in-hospital mortality. Non-shockable rhythm, Killip class > 1 at admission, time to CPR initiation > 5 min and time to ROSC > 20 min but not age were independent predictors for poor neurological outcomes. Conclusions: Age determined a less aggressive management and it was associated with a worse vital prognosis in patients admitted with a SCD. Nevertheless, age was not associated with worse neurological outcomes.

Published
2022
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47. Influencia de las comorbilidades en la decisión del tratamiento invasivo en ancianos con SCASEST

Author

Vicente Pernias, José María García Acuña, Sergio Raposeiras-Roubín, José A. Barrabés, Alberto Cordero, Manuel Martínez-Sellés, Alfredo Bardají, Pablo Díez-Villanueva, Francisco Marín, Juan M. Ruiz-Nodar, Nuria Vicente-Ibarra, Gonzalo L. Alonso Salinas, Pedro Rigueiro, Emad Abu-Assi, Francesc Formiga, Julio Núñez, Eduardo Núñez, Albert Ariza-Solé, and Juan Sanchis

Subjects
Internal medicine, RC31-1245
Abstract

RESUMEN Introducción y objetivos: La comorbilidad en ancianos con síndrome coronario agudo sin elevación del segmento ST empeora el pronóstico. El objetivo fue analizar la influencia de la carga de comorbilidad en la decisión del tratamiento invasivo en ancianos con SCASEST. Métodos: Se incluyeron 7.211 pacientes mayores de 70 años procedentes de 11 registros españoles. Los datos se analizaron en una base de datos conjunta. Se evaluó la presencia de 6 enfermedades simultáneas y su asociación con la realización de coronariografía durante el ingreso. Resultados: La edad media fue de 79 ± 6 años y la puntuación GRACE media fue de 150 ± 21 puntos. Fueron tratados de manera conservadora 1.179 pacientes (16%). La presencia de cada enfermedad se asoció con un menor abordaje invasivo (ajustado por variables clínicas predictivas): enfermedad cerebrovascular (odds ratio [OR] = 0,78; intervalo de confianza del 95% [IC95%], 0,64-0,95; p = 0,01), anemia (OR = 0,64; IC95%, 0,54-0,76; p < 0,0001), insuficiencia renal (OR = 0,65; IC95%, 0,56-0,75; p < 0,0001), arteriopatía periférica (OR = 0,79; IC95%, 0,65-0,96; p = 0,02), enfermedad pulmonar crónica (OR = 0,85; IC95%, 0,71-0,99; p = 0,05) y diabetes mellitus (OR = 0,85; IC95%, 0,74-0,98; p = 0,03). Asimismo, el aumento del número de enfermedades (carga de comorbilidad) se asoció con menor realización de coronariografías, ajustado por la escala GRACE: 1 enfermedad (OR = 0,66; IC95%, 0,54-0,81); 2 (OR = 0,55; IC95%, 0,45-0,69); 3 (OR = 0,37; IC95%, 0,29-0,47); 4 (OR = 0,33; IC95%, 0,24-0,45); ≥ 5 (OR = 0,21; IC95%, 0,12-0,36); todos p < 0,0001, en comparación con ninguna enfermedad. Conclusiones: Conforme aumenta la comorbilidad disminuye la realización de coronariografías en ancianos con síndrome coronario agudo sin elevación del segmento ST. Se necesitan estudios que investiguen la mejor estrategia diagnóstico-terapéutica en estos pacientes.

Published
2021
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48. Impact of comorbidities in the decision of using invasive management in elderly patients with NSTEACS

Author

Vicente Pernias, José María García Acuña, Sergio Raposeiras-Roubín, José A. Barrabés, Alberto Cordero, Manuel Martínez-Sellés, Alfredo Bardají, Pablo Díez-Villanueva, Francisco Marín, Juan M. Ruiz-Nodar, Nuria Vicente-Ibarra, Gonzalo L. Alonso Salinas, Pedro Rigueiro, Emad Abu-Assi, Francesc Formiga, Julio Núñez, Eduardo Núñez, Albert Ariza-Solé, and Juan Sanchis

Subjects
Medicine
Abstract

ABSTRACT Introduction and objectives: The presence of comorbidities in elderly patients with non-ST-segment elevation acute coronary syndrome worsens its prognosis. The objective of the study was to analyze the impact of the burden of comorbidities in the decision of using invasive management in these patients. Methods: A total of 7211 patients > 70 years old from 11 Spanish registries were included. Individual data were analyzed in a common database. We assessed the presence of 6 comorbidities and their association with coronary angiography during admission. Results: The mean age was 79 ± 6 years and the mean CRACE score was 150 ± 21 points. A total of 1179 patients (16%) were treated conservatively. The presence of each comorbidity was associated with less invasive management (adjusted for predictive clinical variables): cerebrovascular disease (OR, 0.78; 95%CI, 0.64-0.95; P = .01), anemia (OR, 0.64; 95%CI, 0.54-0.76; P < .0001), chronic kidney disease (OR, 0.65; 95%CI, 0.56-0.75; P < .0001), peripheral arterial disease (OR, 0.79; 95%CI, 0.65-0.96; P = .02), chronic lung disease (OR, 0.85; IC95%, 0.71-0.99; P = .05), and diabetes mellitus (OR, 0.85; 95%CI, 0.74-0.98; P < .03). The increase in the number of comorbidities (comorbidity burden) was associated with a reduction in coronary angiographies after...

Published
2021
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50. Beneficial effect of corticosteroids in preventing mortality in patients receiving tocilizumab to treat severe COVID-19 illness

Author

Rubio-Rivas, Manuel, Ronda, Mar, Padulles, Ariadna, Mitjavila, Francesca, Riera-Mestre, Antoni, García-Forero, Carlos, Iriarte, Adriana, Mora, Jose M., Padulles, Nuria, Gonzalez, Monica, Solanich, Xavier, Gasa, Merce, Suarez-Cuartin, Guillermo, Sabater, Joan, Perez-Fernandez, Xose L., Santacana, Eugenia, Leiva, Elisabet, Ariza-Sole, Albert, Dallaglio, Paolo D., Quero, Maria, Soriano, Antonio, Pasqualetto, Alberto, Koo, Maylin, Esteve, Virginia, Antoli, Arnau, Moreno-Gonzalez, Rafael, Yun, Sergi, Cerda, Pau, Llaberia, Mariona, Formiga, Francesc, Fanlo, Marta, Montero, Abelardo, Chivite, David, Capdevila, Olga, Bolao, Ferran, Pinto, Xavier, Llop, Josep, Sabate, Antoni, Guardiola, Jordi, Cruzado, Josep M., Comin-Colet, Josep, Santos, Salud, Jodar, Ramon, and Corbella, Xavier

Published
2020
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