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2. MMR vaccination induces trained immunity via functional and metabolic reprogramming of [gamma][delta] T cells

Author

Roring, Rutger J., Debisarun, Priya A., Botey-Bataller, Javier, Suen, Tsz Kin, Bulut, Ozlem, Kilic, Gizem, Koeken, Valerie A.C.M., Sarlea, Andrei, Bahrar, Harsh, Dijkstra, Helga, Lemmers, Heidi, Gossling, Katharina L., Ruchel, Nadine, Ostermann, Philipp N., Muller, Lisa, Schaal, Heiner, Adams, Ortwin, Borkhardt, Arndt, Ariyurek, Yavuz, de Meijer, Emile J., Kloet, Susan L., Oever, Jaap ten, Placek, Katarzyna, Li, Yang, and Netea, Mihai G.

Subjects
Vaccination -- Health aspects, Tetanus antitoxin -- Health aspects, T cells -- Health aspects, BCG vaccines -- Health aspects, RNA sequencing -- Health aspects, BCG -- Health aspects, Measles-mumps-rubella vaccine -- Health aspects, Ethylenediaminetetraacetic acid -- Health aspects, Killer cells -- Health aspects, Health care industry
Abstract

The measles, mumps, and rubella (MMR) vaccine protects against all-cause mortality in children, but the immunological mechanisms mediating these effects are poorly known. We systematically investigated whether MMR can induce long- term functional changes in innate immune cells, a process termed trained immunity, that could at least partially mediate this heterologous protection. In a randomized, placebo-controlled trial, 39 healthy adults received either the MMR vaccine or a placebo. Using single-cell RNA-Seq, we found that MMR caused transcriptomic changes in [CD14.sup.+] monocytes and NK cells, but most profoundly in [gamma][delta] T cells. Monocyte function was not altered by MMR vaccination. In contrast, the function of [gamma][delta] T cells was markedly enhanced by MMR vaccination, with higher production of TNF and IFN-[gamma], as well as upregulation of cellular metabolic pathways. In conclusion, we describe a trained immunity program characterized by modulation of [gamma][delta] T cell function induced by MMR vaccination., Introduction Vaccines are developed to target specific pathogens. However, an accumulating body of evidence suggests that certain live-attenuated vaccines provide a broad spectrum of protection against heterologous infections as well [...]

Published
2024
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6. Eicosapentaenoic acid induces an anti-inflammatory transcriptomic landscape in T cells implicating a pathway independent of triglyceride lowering in cardiovascular risk reduction

Author

Reilly, Nathalie A., primary, Dekkers, Koen F., additional, Molenaar, Jeroen, additional, Arumugam, Sinthuja, additional, Kuipers, Thomas B., additional, Ariyurek, Yavuz, additional, Hoeksema, Marten A., additional, Jukema, J. Wouter, additional, and Heijmans, Bastiaan T., additional

Published
2024
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7. CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

Author

Vukic, Maja, primary, Chouaref, Jihed, additional, Della Chiara, Veronica, additional, Dogan, Serkan, additional, Ratner, Fallon, additional, Hogenboom, Jenna Z. M., additional, Epp, Trevor A., additional, Chawengsaksophak, Kallayanee, additional, Vonk, Kelly K. D., additional, Breukel, Cor, additional, Ariyurek, Yavuz, additional, San Leon Granado, David, additional, Kloet, Susan L., additional, and Daxinger, Lucia, additional

Published
2024
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8. MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells

Author

Röring, Rutger J., primary, Debisarun, Priya A., additional, Botey-Bataller, Javier, additional, Suen, Tsz Kin, additional, Bulut, Ozlem, additional, Kilic, Gizem, additional, Koeken, Valerie A.C.M., additional, Sarlea, Andrei, additional, Bahrar, Harsh, additional, Dijkstra, Helga, additional, Lemmers, Heidi, additional, Gössling, Katharina L., additional, Rüchel, Nadine, additional, Ostermann, Philipp N., additional, Müller, Lisa, additional, Schaal, Heiner, additional, Adams, Ortwin, additional, Borkhardt, Arndt, additional, Ariyurek, Yavuz, additional, de Meijer, Emile J., additional, Kloet, Susan L., additional, ten Oever, Jaap, additional, Placek, Katarzyna, additional, Li, Yang, additional, and Netea, Mihai G., additional

Published
2024
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9. Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice

Author

Kuijper, Elsa C., primary, Overzier, Maurice, additional, Suidgeest, Ernst, additional, Dzyubachyk, Oleh, additional, Maguin, Cecile, additional, Pérot, Jean-Baptiste, additional, Flament, Julien, additional, Ariyurek, Yavuz, additional, Mei, Hailiang, additional, Buijsen, Ronald A.M., additional, van der Weerd, Louise, additional, and van Roon-Mom, Willeke, additional

Published
2023
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13. MMR vaccination induces a trained immunity program characterized by functional and metabolic reprogramming of γδ T cells

Author

Röring, Rutger J., primary, Debisarun, Priya A., additional, Botey-Bataller, Javier, additional, Suen, Tsz Kin, additional, Bulut, Özlem, additional, Kilic, Gizem, additional, Koeken, Valerie A. C. M., additional, Sarlea, Andrei, additional, Bahrar, Harsh, additional, Dijkstra, Helga, additional, Lemmers, Heidi, additional, Gössling, Katharina L., additional, Rüchel, Nadine, additional, Ostermann, Philipp N., additional, Müller, Lisa, additional, Schaal, Heiner, additional, Adams, Ortwin, additional, Borkhardt, Arndt, additional, Ariyurek, Yavuz, additional, de Meijer, Emile J., additional, Kloet, Susan, additional, ten Oever, Jaap, additional, Placek, Katarzyna, additional, Li, Yang, additional, and Netea, Mihai G., additional

Published
2022
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18. Adenine base editing of the polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy

Author

Šikrová, Darina, Cadar, Vlad A, Ariyurek, Yavuz, Laros, Jeroen F J, Balog, Judit, and van der Maarel, Silvère M

Subjects
musculoskeletal diseases, DUX4, base editing, polyadenylation signal, facioscapulohumeral muscular dystrophy, CRISPR-Cas9, gene therapy
Abstract

Facioscapulohumeral muscular dystrophy (FSHD) is caused by chromatin relaxation of the D4Z4 repeat resulting in misexpression of the D4Z4-encoded DUX4 gene in skeletal muscle. One of the key genetic requirements for the stable production of full-length DUX4 mRNA in skeletal muscle is a functional polyadenylation signal (ATTAAA) in exon three of DUX4 that is used in somatic cells. Base editors hold great promise to treat DNA lesions underlying genetic diseases through their ability to carry out specific and rapid nucleotide mutagenesis even in postmitotic cells such as skeletal muscle. In this study, we present a simple and straightforward strategy for mutagenesis of the somatic DUX4 polyadenylation signal by adenine base editing in immortalized myoblasts derived from independent FSHD-affected individuals. We show that mutating this critical cis-regulatory element results in downregulation of DUX4 mRNA and its direct transcriptional target genes. Our findings identify the somatic DUX4 polyadenylation signal as a therapeutic target and represent the first step toward clinical application of the CRISPR-Cas9 base editing platform for FSHD gene therapy.

Published
2021

20. Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene

Author

Yu Sun, Almomani, Rowida, Aten, Emmelien, Celli, Jacopo, Heijden, Jaap van der, Venselaar, Hanka, Robertson, Stephen P., Baroncini, Anna, Franco, Brunella, Basel-Vanagaite, Lina, Horii, Emiko, Drut, Ricardo, Ariyurek, Yavuz, Dunnen, Johan T. den, and Breuning, Martijn H.

Subjects
Dwarfism -- Genetic aspects, Gene expression -- Analysis, Gene mutations -- Analysis, Nucleotides -- Research, Biological sciences
Abstract

X-exome capture and sequencing was performed to identify a mutation at the last nucleotide of exon 31 of the FLNA gene as the most likely cause of the terminal osseous dysplasia (TOD) disease which is an x-linked dominant male-lethal disease characterized by skeletal dysplasia of the limbs, pigmentary defects of the skin and recurrent digital fibroma with onset in female infancy. The data obtained revealed that TOD is caused by single recurrent mutation in the FLNA gene.

Published
2010

21. Detailed genetic and functional analysis of the hDMDdel52/mdx mouse model

Author

Yavas, Alper, primary, Weij, Rudie, additional, van Putten, Maaike, additional, Kourkouta, Eleni, additional, Beekman, Chantal, additional, Puoliväli, Jukka, additional, Bragge, Timo, additional, Ahtoniemi, Toni, additional, Knijnenburg, Jeroen, additional, Hoogenboom, Marlies Elisabeth, additional, Ariyurek, Yavuz, additional, Aartsma-Rus, Annemieke, additional, van Deutekom, Judith, additional, and Datson, Nicole, additional

Published
2020
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27. Deep Sequencing to Reveal New Variants in Pooled DNA Samples

Author

Out, Astrid A., Minderhout, Ivonne J.H.M. van, Goeman, Jelle J., Ariyurek, Yavuz, Ossowski, Stephan, Schneeberger, Korbinian, Weigel, Detlef, Galen, Michiel van, Taschner, Peter E.M., Tops, Carli M.J., Breuning, Martijn H., Ommen, Gert-Jan B. van, Dunnen, Johan T. den, Devilee, Peter, and Hes, Frederik J.

Published
2009
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30. Immune stimuli shape the small non-coding transcriptome of extracellular vesicles released by dendritic cells

Author

Driedonks, Tom A P, van der Grein, Susanne G, Ariyurek, Yavuz, Buermans, Henk P J, Jekel, Henrike, Chow, Franklin W N, Wauben, Marca H M, Buck, Amy H, 't Hoen, Peter A C, Nolte-'t Hoen, Esther N M, LS Celbiologie-Algemeen, and dB&C I&I

Subjects
Immune activation, Immune suppression, Biomarker, Extracellular RNA, Small RNA sequencing
Abstract

The release and uptake of nano-sized extracellular vesicles (EV) is a highly conserved means of intercellular communication. The molecular composition of EV, and thereby their signaling function to target cells, is regulated by cellular activation and differentiation stimuli. EV are regarded as snapshots of cells and are, therefore, in the limelight as biomarkers for disease. Although research on EV-associated RNA has predominantly focused on microRNAs, the transcriptome of EV consists of multiple classes of small non-coding RNAs with potential gene-regulatory functions. It is not known whether environmental cues imposed on cells induce specific changes in a broad range of EV-associated RNA classes. Here, we investigated whether immune-activating or -suppressing stimuli imposed on primary dendritic cells affected the release of various small non-coding RNAs via EV. The small RNA transcriptomes of highly pure EV populations free from ribonucleoprotein particles were analyzed by RNA sequencing and RT-qPCR. Immune stimulus-specific changes were found in the miRNA, snoRNA, and Y-RNA content of EV from dendritic cells, whereas tRNA and snRNA levels were much less affected. Only part of the changes in EV-RNA content reflected changes in cellular RNA, which urges caution in interpreting EV as snapshots of cells. By comprehensive analysis of RNA obtained from highly purified EV, we demonstrate that multiple RNA classes contribute to genetic messages conveyed via EV. The identification of multiple RNA classes that display cell stimulation-dependent association with EV is the prelude to unraveling the function and biomarker potential of these EV-RNAs.

Published
2018

31. Additional file 1: of Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing

Author

Anvar, Seyed, Allard, Guy, Tseng, Elizabeth, Sheynkman, Gloria, Klerk, Eleonora De, Vermaat, Martijn, Yin, Raymund, Johansson, Hans, Ariyurek, Yavuz, Dunnen, Johan Den, Turner, Stephen, and Hoen, Peter

Abstract

This document contains additional supporting evidence for this study that are presented in form of supplemental tables and figures. (PDF 11005 kb)

Published
2018
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32. New methods for next generation sequencing based microRNA expression profiling

Author

den Dunnen Johan T, van Ommen Gertjan, Ariyurek Yavuz, Buermans Henk PJ, and 't Hoen Peter AC

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background MicroRNAs are small non-coding RNA transcripts that regulate post-transcriptional gene expression. The millions of short sequence reads generated by next generation sequencing technologies make this technique explicitly suitable for profiling of known and novel microRNAs. A modification to the small-RNA expression kit (SREK, Ambion) library preparation method for the SOLiD sequencing platform is described to generate microRNA sequencing libraries that are compatible with the Illumina Genome Analyzer. Results High quality sequencing libraries can successfully be prepared from as little as 100 ng small RNA enriched RNA. An easy to use perl-based analysis pipeline called E-miR was developed to handle the sequencing data in several automated steps including data format conversion, 3' adapter removal, genome alignment and annotation to non-coding RNA transcripts. The sample preparation and E-miR pipeline were used to identify 37 cardiac enriched microRNAs in stage 16 chicken embryos. Isomir expression profiles between the heart and embryo were highly correlated for all miRNAs suggesting that tissue or cell specific miRNA modifications do not occur. Conclusions In conclusion, our alternative sample preparation method can successfully be applied to generate high quality miRNA sequencing libraries for the Illumina genome analyzer.

Published
2010
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33. Can subtle changes in gene expression be consistently detected with different microarray platforms?

Author

Kuiper Rowan, de Hollander Mattias, Ariyurek Yavuz, Vossen Rolf HAM, Schenk Geert J, Vreugdenhil Erno, 't Hoen Peter AC, Pedotti Paola, van Ommen Gertjan JB, den Dunnen Johan T, Boer Judith M, and de Menezes Renée X

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The comparability of gene expression data generated with different microarray platforms is still a matter of concern. Here we address the performance and the overlap in the detection of differentially expressed genes for five different microarray platforms in a challenging biological context where differences in gene expression are few and subtle. Results Gene expression profiles in the hippocampus of five wild-type and five transgenic δC-doublecortin-like kinase mice were evaluated with five microarray platforms: Applied Biosystems, Affymetrix, Agilent, Illumina, LGTC home-spotted arrays. Using a fixed false discovery rate of 10% we detected surprising differences between the number of differentially expressed genes per platform. Four genes were selected by ABI, 130 by Affymetrix, 3,051 by Agilent, 54 by Illumina, and 13 by LGTC. Two genes were found significantly differentially expressed by all platforms and the four genes identified by the ABI platform were found by at least three other platforms. Quantitative RT-PCR analysis confirmed 20 out of 28 of the genes detected by two or more platforms and 8 out of 15 of the genes detected by Agilent only. We observed improved correlations between platforms when ranking the genes based on the significance level than with a fixed statistical cut-off. We demonstrate significant overlap in the affected gene sets identified by the different platforms, although biological processes were represented by only partially overlapping sets of genes. Aberrances in GABA-ergic signalling in the transgenic mice were consistently found by all platforms. Conclusion The different microarray platforms give partially complementary views on biological processes affected. Our data indicate that when analyzing samples with only subtle differences in gene expression the use of two different platforms might be more attractive than increasing the number of replicates. Commercial two-color platforms seem to have higher power for finding differentially expressed genes between groups with small differences in expression.

Published
2008
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34. Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

Author

Vértesy, Ábel, Arindrarto, Wibowo, Roost, Matthias S., Reinius, Björn, Torrens-Juaneda, Vanessa, Bialecka, Monika, Moustakas, Ioannis, Ariyurek, Yavuz, Kuijk, Ewart, Mei, Hailiang, Sandberg, Rickard, Van Oudenaarden, Alexander, Chuva De Sousa Lopes, Susana M., Vértesy, Ábel, Arindrarto, Wibowo, Roost, Matthias S., Reinius, Björn, Torrens-Juaneda, Vanessa, Bialecka, Monika, Moustakas, Ioannis, Ariyurek, Yavuz, Kuijk, Ewart, Mei, Hailiang, Sandberg, Rickard, Van Oudenaarden, Alexander, and Chuva De Sousa Lopes, Susana M.

Published
2018

35. Immune stimuli shape the small non-coding transcriptome of extracellular vesicles released by dendritic cells

Author

LS Celbiologie-Algemeen, dB&C I&I, Driedonks, Tom A P, van der Grein, Susanne G, Ariyurek, Yavuz, Buermans, Henk P J, Jekel, Henrike, Chow, Franklin W N, Wauben, Marca H M, Buck, Amy H, 't Hoen, Peter A C, Nolte-'t Hoen, Esther N M, LS Celbiologie-Algemeen, dB&C I&I, Driedonks, Tom A P, van der Grein, Susanne G, Ariyurek, Yavuz, Buermans, Henk P J, Jekel, Henrike, Chow, Franklin W N, Wauben, Marca H M, Buck, Amy H, 't Hoen, Peter A C, and Nolte-'t Hoen, Esther N M

Published
2018

36. Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

Author

Genetica, CMM Groep Cuppen, Cancer, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Vértesy, Ábel, Arindrarto, Wibowo, Roost, Matthias S., Reinius, Björn, Torrens-Juaneda, Vanessa, Bialecka, Monika, Moustakas, Ioannis, Ariyurek, Yavuz, Kuijk, Ewart, Mei, Hailiang, Sandberg, Rickard, Van Oudenaarden, Alexander, Chuva De Sousa Lopes, Susana M., Genetica, CMM Groep Cuppen, Cancer, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Vértesy, Ábel, Arindrarto, Wibowo, Roost, Matthias S., Reinius, Björn, Torrens-Juaneda, Vanessa, Bialecka, Monika, Moustakas, Ioannis, Ariyurek, Yavuz, Kuijk, Ewart, Mei, Hailiang, Sandberg, Rickard, Van Oudenaarden, Alexander, and Chuva De Sousa Lopes, Susana M.

Published
2018

37. Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

Author

Vértesy, Ábel, primary, Arindrarto, Wibowo, additional, Roost, Matthias S., additional, Reinius, Björn, additional, Torrens-Juaneda, Vanessa, additional, Bialecka, Monika, additional, Moustakas, Ioannis, additional, Ariyurek, Yavuz, additional, Kuijk, Ewart, additional, Mei, Hailiang, additional, Sandberg, Rickard, additional, van Oudenaarden, Alexander, additional, and Chuva de Sousa Lopes, Susana M., additional

Published
2018
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39. Full-length mRNA sequencing uncovers a widespread coupling between transcription and mRNA processing

Author

Anvar, Seyed Yahya, primary, Allard, Guy, additional, Tseng, Elizabeth, additional, Sheynkman, Gloria, additional, de Klerk, Eleonora, additional, Vermaat, Martijn, additional, Yin, Raymund H., additional, Johansson, Hans E., additional, Ariyurek, Yavuz, additional, den Dunnen, Johan T., additional, Turner, Stephen W., additional, and 't Hoen, Peter A.C., additional

Published
2017
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41. KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas

Author

Roost, Matthias S., Van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P., Arindrarto, Wibowo, Devalla, Harsha D., Passier, Robert, Mummery, Christine L., Carlotti, Françoise, De Koning, Eelco J P, Van Zwet, Erik W., Goeman, Jelle J., Chuva De Sousa Lopes, Susana M., Roost, Matthias S., Van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P., Arindrarto, Wibowo, Devalla, Harsha D., Passier, Robert, Mummery, Christine L., Carlotti, Françoise, De Koning, Eelco J P, Van Zwet, Erik W., Goeman, Jelle J., and Chuva De Sousa Lopes, Susana M.

Published
2015

42. KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas

Author

Roost, Matthias S, van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P, Arindrarto, Wibowo, Devalla, Harsha D, Passier, Robert, Mummery, Christine L, Carlotti, Françoise, de Koning, Eelco J P, van Zwet, Erik W, Goeman, Jelle J, Chuva de Sousa Lopes, Susana M, Roost, Matthias S, van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P, Arindrarto, Wibowo, Devalla, Harsha D, Passier, Robert, Mummery, Christine L, Carlotti, Françoise, de Koning, Eelco J P, van Zwet, Erik W, Goeman, Jelle J, and Chuva de Sousa Lopes, Susana M

Abstract

Differentiated derivatives of human pluripotent stem cells in culture are generally phenotypically immature compared to their adult counterparts. Their identity is often difficult to determine with certainty because little is known about their human fetal equivalents in vivo. Cellular identity and signaling pathways directing differentiation are usually determined by extrapolating information from either human adult tissue or model organisms, assuming conservation with humans. To resolve this, we generated a collection of human fetal transcriptional profiles at different developmental stages. Moreover, we developed an algorithm, KeyGenes, which uses this dataset to quantify the extent to which next-generation sequencing or microarray data resemble specific cell or tissue types in the human fetus. Using KeyGenes combined with the human fetal atlas, we identified multiple cell and tissue samples unambiguously on a limited set of features. We thus provide a flexible and expandable platform to monitor and evaluate the efficiency of differentiation in vitro.

Published
2015

43. KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas

Author

Hubrecht Institute with UMC, Regenerative Medicine and Stem Cells, Roost, Matthias S., Van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P., Arindrarto, Wibowo, Devalla, Harsha D., Passier, Robert, Mummery, Christine L., Carlotti, Françoise, De Koning, Eelco J P, Van Zwet, Erik W., Goeman, Jelle J., Chuva De Sousa Lopes, Susana M., Hubrecht Institute with UMC, Regenerative Medicine and Stem Cells, Roost, Matthias S., Van Iperen, Liesbeth, Ariyurek, Yavuz, Buermans, Henk P., Arindrarto, Wibowo, Devalla, Harsha D., Passier, Robert, Mummery, Christine L., Carlotti, Françoise, De Koning, Eelco J P, Van Zwet, Erik W., Goeman, Jelle J., and Chuva De Sousa Lopes, Susana M.

Published
2015

44. A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Author

Palmer, Nicholette D, McDonough, Caitrin W, Hicks, Pamela J, Roh, Bong H, Wing, Maria R, An, S Sandy, Hester, Jessica M, Cooke, Jessica N, Bostrom, Meredith A, Rudock, Megan E, Talbert, Matthew E, Lewis, Joshua P, DIAGRAM Consortium, MAGIC Investigators, Ferrara, Assiamira, Lu, Lingyi, Ziegler, Julie T, Sale, Michele M, Divers, Jasmin, Shriner, Daniel, Adeyemo, Adebowale, Rotimi, Charles N, Ng, Maggie CY, Langefeld, Carl D, Freedman, Barry I, Bowden, Donald W, Voight, Benjamin F, Scott, Laura J, Steinthorsdottir, Valgerdur, Morris, Andrew P, Dina, Christian, Welch, Ryan P, Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S, Thorleifsson, Gudmar, McCulloch, Laura J, Ferreira, Teresa, Grallert, Harald, Amin, Najaf, Wu, Guanming, Willer, Cristen J, Raychaudhuri, Soumya, McCarroll, Steve A, Langenberg, Claudia, Hofmann, Oliver M, Dupuis, Josée, Qi, Lu, Segrè, Ayellet V, Van Hoek, Mandy, Navarro, Pau, Ardlie, Kristin, Balkau, Beverley, Benediktsson, Rafn, Bennett, Amanda J, Blagieva, Roza, Boerwinkle, Eric, Bonnycastle, Lori L, Boström, Kristina Bengtsson, Bravenboer, Bert, Bumpstead, Suzannah, Burtt, Noël P, Charpentier, Guillaume, Chines, Peter S, Cornelis, Marilyn, Couper, David J, Crawford, Gabe, Doney, Alex SF, Elliott, Katherine S, Elliott, Amanda L, Erdos, Michael R, Fox, Caroline S, Franklin, Christopher S, Ganser, Martha, Gieger, Christian, Grarup, Niels, Green, Todd, Griffin, Simon, Groves, Christopher J, Guiducci, Candace, Hadjadj, Samy, Hassanali, Neelam, Herder, Christian, Isomaa, Bo, Jackson, Anne U, Johnson, Paul RV, Jørgensen, Torben, Kao, Wen HL, Klopp, Norman, Kong, Augustine, Kraft, Peter, Kuusisto, Johanna, Lauritzen, Torsten, Li, Man, Lieverse, Aloysius, Lindgren, Cecilia M, Lyssenko, Valeriya, Marre, Michel, Meitinger, Thomas, Midthjell, Kristian, Morken, Mario A, Narisu, Narisu, Nilsson, Peter, Owen, Katharine R, Payne, Felicity, Perry, John RB, Petersen, Ann-Kristin, Platou, Carl, Proença, Christine, Prokopenko, Inga, Rathmann, Wolfgang, Rayner, N William, Robertson, Neil R, Rocheleau, Ghislain, Roden, Michael, Sampson, Michael J, Saxena, Richa, Shields, Beverley M, Shrader, Peter, Sigurdsson, Gunnar, Sparsø, Thomas, Strassburger, Klaus, Stringham, Heather M, Sun, Qi, Swift, Amy J, Thorand, Barbara, Tichet, Jean, Tuomi, Tiinamaija, Van Dam, Rob M, Van Haeften, Timon W, Van Herpt, Thijs, Van Vliet-Ostaptchouk, Jana V, Walters, G Bragi, Weedon, Michael N, Wijmenga, Cisca, Witteman, Jacqueline, Bergman, Richard N, Cauchi, Stephane, Collins, Francis S, Gloyn, Anna L, Gyllensten, Ulf, Hansen, Torben, Hide, Winston A, Hitman, Graham A, Hofman, Albert, Hunter, David J, Hveem, Kristian, Laakso, Markku, Mohlke, Karen L, Morris, Andrew D, Palmer, Colin NA, Pramstaller, Peter P, Rudan, Igor, Sijbrands, Eric, Stein, Lincoln D, Tuomilehto, Jaakko, Uitterlinden, Andre, Walker, Mark, Wareham, Nicholas J, Watanabe, Richard M, Abecasis, Goncalo R, Boehm, Bernhard O, Campbell, Harry, Daly, Mark J, Hattersley, Andrew T, Hu, Frank B, Meigs, James B, Pankow, James S, Pedersen, Oluf, Wichmann, H-Erich, Barroso, Inês, Florez, Jose C, Frayling, Timothy M, Groop, Leif, Sladek, Rob, Thorsteinsdottir, Unnur, Wilson, James F, Illig, Thomas, Froguel, Philippe, Van Duijn, Cornelia M, Stefansson, Kari, Altshuler, David, Boehnke, Michael, McCarthy, Mark I, Soranzo, Nicole, Wheeler, Eleanor, Glazer, Nicole L, Bouatia-Naji, Nabila, Mägi, Reedik, Randall, Joshua, Johnson, Toby, Elliott, Paul, Rybin, Denis, Henneman, Peter, Dehghan, Abbas, Hottenga, Jouke Jan, Song, Kijoung, Goel, Anuj, Egan, Josephine M, Lajunen, Taina, Doney, Alex, Kanoni, Stavroula, Cavalcanti-Proença, Christine, Kumari, Meena, Timpson, Nicholas J, Zabena, Carina, Ingelsson, Erik, An, Ping, O'Connell, Jeffrey, Luan, Jian'an, Elliott, Amanda, McCarroll, Steven A, Roccasecca, Rosa Maria, Pattou, François, Sethupathy, Praveen, Ariyurek, Yavuz, Barter, Philip, Beilby, John P, Ben-Shlomo, Yoav, Bergmann, Sven, Bochud, Murielle, Bonnefond, Amélie, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Bumpstead, Suzannah J, Chen, Yii-Der Ida, Chines, Peter, Clarke, Robert, Coin, Lachlan JM, Cooper, Matthew N, Crisponi, Laura, Day, Ian NM, De Geus, Eco JC, Delplanque, Jerome, Fedson, Annette C, Fischer-Rosinsky, Antje, Forouhi, Nita G, Frants, Rune, Franzosi, Maria Grazia, Galan, Pilar, Goodarzi, Mark O, Graessler, Jürgen, Grundy, Scott, Gwilliam, Rhian, Hallmans, Göran, Hammond, Naomi, Han, Xijing, Hartikainen, Anna-Liisa, Hayward, Caroline, Heath, Simon C, Hercberg, Serge, Hicks, Andrew A, Hillman, David R, Hingorani, Aroon D, Hui, Jennie, Hung, Joe, Jula, Antti, Kaakinen, Marika, Kaprio, Jaakko, Kesaniemi, Y Antero, Kivimaki, Mika, Knight, Beatrice, Koskinen, Seppo, Kovacs, Peter, Kyvik, Kirsten Ohm, Lathrop, G Mark, Lawlor, Debbie A, Le Bacquer, Olivier, Lecoeur, Cécile, Li, Yun, Mahley, Robert, Mangino, Massimo, Manning, Alisa K, Martínez-Larrad, María Teresa, McAteer, Jarred B, McPherson, Ruth, Meisinger, Christa, Melzer, David, Meyre, 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H, Willemsen, Gonneke, Witteman, Jaqueline CM, Yarnell, John WG, Zelenika, Diana, Zethelius, Björn, Zhai, Guangju, Zhao, Jing Hua, Zillikens, M Carola, Borecki, Ingrid B, Loos, Ruth JF, Meneton, Pierre, Magnusson, Patrik KE, Nathan, David M, Williams, Gordon H, Silander, Kaisa, Salomaa, Veikko, Smith, George Davey, Bornstein, Stefan R, Schwarz, Peter, Spranger, Joachim, Karpe, Fredrik, Shuldiner, Alan R, Cooper, Cyrus, Dedoussis, George V, Serrano-Ríos, Manuel, Lind, Lars, Palmer, Lyle J, Franks, Paul W, Ebrahim, Shah, Marmot, Michael, Kao, WH Linda, Pramstaller, Peter Paul, Wright, Alan F, Stumvoll, Michael, Hamsten, Anders, Buchanan, Thomas A, Valle, Timo T, Rotter, Jerome I, Siscovick, David S, Penninx, Brenda WJH, Boomsma, Dorret I, Deloukas, Panos, Spector, Timothy D, Ferrucci, Luigi, Cao, Antonio, Scuteri, Angelo, Schlessinger, David, Uda, Manuela, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Waterworth, Dawn M, Vollenweider, Peter, Peltonen, Leena, Mooser, Vincent, Sladek, Robert, 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Uitterlinden, A, Walker, M, Wareham, Nj, Watanabe, Rm, Abecasis, Gr, Boehm, Bo, Campbell, H, Daly, Mj, Hattersley, At, Hu, Fb, Meigs, Jb, Pankow, J, Pedersen, O, Wichmann, He, Barroso, I, Florez, Jc, Frayling, Tm, Groop, L, Sladek, R, Thorsteinsdottir, U, Wilson, Jf, Illig, T, Froguel, P, van Duijn, Cm, Stefansson, K, Altshuler, D, Boehnke, M, Mccarthy, Mi, Soranzo, N, Wheeler, E, Glazer, Nl, Bouatia Naji, N, Mägi, R, Randall, J, Johnson, T, Elliott, P, Rybin, D, Henneman, P, Dehghan, A, Hottenga, Jj, Song, K, Goel, A, Egan, Jm, Lajunen, T, Kanoni, S, Cavalcanti Proença, C, Kumari, M, Timpson, Nj, Zabena, C, Ingelsson, E, An, P, O'Connell, J, Luan, J, Elliott, A, Roccasecca, Rm, Pattou, F, Sethupathy, P, Ariyurek, Y, Barter, P, Beilby, Jp, Ben Shlomo, Y, Bergmann, S, Bochud, M, Bonnefond, A, Borch Johnsen, K, Böttcher, Y, Brunner, E, Bumpstead, Sj, Chen, Yd, Clarke, R, Coin, Lj, Cooper, Mn, Crisponi, L, Day, In, de Geus, Ej, Delplanque, J, Fedson, Ac, Fischer Rosinsky, A, Forouhi, Ng, 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Subjects
Netherlands Twin Register (NTR), Male, Adult, African Americans/genetics, Aged, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2/ethnology, Diabetes Mellitus, Type 2/genetics, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Meta-Analysis as Topic, Middle Aged, Polymorphism, Single Nucleotide, Validation Studies as Topic, Medicin och hälsovetenskap, Linkage disequilibrium, Genetic Screens, endocrine system diseases, lcsh:Medicine, Genome-wide association study, Medical and Health Sciences, 0302 clinical medicine, Endocrinology, Genome Sequencing, lcsh:Science, Medicine(all), Genetics, African Americans, 0303 health sciences, education.field_of_study, INSULIN-RESISTANCE, Multidisciplinary, Agricultural and Biological Sciences(all), LARGE-SCALE ASSOCIATION, STAGE RENAL-DISEASE, COMMON VARIANTS, Genomics, Medicine, Research Article, SUSCEPTIBILITY LOCI, General Science & Technology, Population, Single-nucleotide polymorphism, Biology, DIAGRAM Consortium, 03 medical and health sciences, MAGIC Investigators, SDG 3 - Good Health and Well-being, Genetic linkage, MD Multidisciplinary, Genome-Wide Association Studies, SNP, ddc:610, education, Genotyping, 030304 developmental biology, Diabetic Endocrinology, LINKAGE ANALYSIS, Biochemistry, Genetics and Molecular Biology(all), lcsh:R, TCF7L2 GENE, Case-control study, Computational Biology, nutritional and metabolic diseases, Human Genetics, Diabetes Mellitus Type 2, Stage renal-disease, large-scale association, Susceptibility loci, Insulin-resistance, Fasting glucose, Tissue factor, Homeodomain protein, Linkage analysis, Common variants, TCF7L2 gene, Black or African American, Diabetes Mellitus, Type 2, TISSUE FACTOR, Genetics of Disease, HOMEODOMAIN PROTEIN, Genetic Polymorphism, lcsh:Q, Genome Expression Analysis, 030217 neurology & neurosurgery, Population Genetics, FASTING GLUCOSE
Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Published
2012

45. KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas

Author

Roost, Matthias S., primary, van Iperen, Liesbeth, additional, Ariyurek, Yavuz, additional, Buermans, Henk P., additional, Arindrarto, Wibowo, additional, Devalla, Harsha D., additional, Passier, Robert, additional, Mummery, Christine L., additional, Carlotti, Françoise, additional, de Koning, Eelco J.P., additional, van Zwet, Erik W., additional, Goeman, Jelle J., additional, and Chuva de Sousa Lopes, Susana M., additional

Published
2015
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49. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Author

Dupuis, Josée, Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Soranzo, Nicole, Jackson, Anne U, Wheeler, Eleanor, Glazer, Nicole L, Bouatia-Naji, Nabila, Gloyn, Anna L, Lindgren, Cecilia M, Mägi, Reedik, Morris, Andrew P, Randall, Joshua, Johnson, Toby, Elliott, Paul, Rybin, Denis, Thorleifsson, Gudmar, Steinthorsdottir, Valgerdur, Henneman, Peter, Grallert, Harald, Dehghan, Abbas, Hottenga, Jouke Jan, Franklin, Christopher S, Navarro, Pau, Song, Kijoung, Goel, Anuj, Perry, John R B, Egan, Josephine M, Lajunen, Taina, Grarup, Niels, Sparsø, Thomas, Doney, Alex, Voight, Benjamin F, Stringham, Heather M, Li, Man, Kanoni, Stavroula, Shrader, Peter, Cavalcanti-Proença, Christine, Kumari, Meena, Qi, Lu, Timpson, Nicholas J, Gieger, Christian, Zabena, Carina, Rocheleau, Ghislain, Ingelsson, Erik, An, Ping, O'Connell, Jeffrey, Luan, Jian'an, Elliott, Amanda, McCarroll, Steven A, Payne, Felicity, Roccasecca, Rosa Maria, Pattou, François, Sethupathy, Praveen, Ardlie, Kristin, Ariyurek, Yavuz, Balkau, Beverley, Barter, Philip, Beilby, John P, Ben-Shlomo, Yoav, Benediktsson, Rafn, Bennett, Amanda J, Bergmann, Sven, Bochud, Murielle, Boerwinkle, Eric, Bonnefond, Amélie, Bonnycastle, Lori L, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Bumpstead, Suzannah J, Charpentier, Guillaume, Chen, Yii-Der Ida, Chines, Peter, Clarke, Robert, Coin, Lachlan J M, Cooper, Matthew N, Cornelis, Marilyn, Crawford, Gabe, Crisponi, Laura, Day, Ian N M, de Geus, Eco J C, Delplanque, Jerome, Dina, Christian, Erdos, Michael R, Fedson, Annette C, Fischer-Rosinsky, Antje, Forouhi, Nita G, Fox, Caroline S, Frants, Rune, Franzosi, Maria Grazia, Galan, Pilar, Goodarzi, Mark O, Graessler, Jürgen, Groves, Christopher J, Grundy, Scott, Gwilliam, Rhian, Gyllensten, Ulf, Hadjadj, Samy, Hallmans, Göran, Hammond, Naomi, Han, Xijing, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hayward, Caroline, Heath, Simon C, Hercberg, Serge, Herder, Christian, Hicks, Andrew A, Hillman, David R, Hingorani, Aroon D, Hofman, Albert, Hui, Jennie, Hung, Joe, Isomaa, Bo, Johnson, Paul R V, Jørgensen, Torben, Jula, Antti, Kaakinen, Marika, Kaprio, Jaakko, Kesaniemi, Y Antero, Kivimaki, Mika, Knight, Beatrice, Koskinen, Seppo, Kovacs, Peter, Kyvik, Kirsten Ohm, Lathrop, G Mark, Lawlor, Debbie A, Le Bacquer, Olivier, Lecoeur, Cécile, Li, Yun, Lyssenko, Valeriya, Mahley, Robert, Mangino, Massimo, Manning, Alisa K, Martínez-Larrad, María Teresa, McAteer, Jarred B, McCulloch, Laura J, McPherson, Ruth, Meisinger, Christa, Melzer, David, Meyre, David, Mitchell, Braxton D, Morken, Mario A, Mukherjee, Sutapa, Naitza, Silvia, Narisu, Narisu, Neville, Matthew J, Oostra, Ben A, Orrù, Marco, Pakyz, Ruth, Palmer, Colin N A, Paolisso, Giuseppe, Pattaro, Cristian, Pearson, Daniel, Peden, John F, Pedersen, Nancy L, Perola, Markus, Pfeiffer, Andreas F H, Pichler, Irene, Polasek, Ozren, Posthuma, Danielle, Potter, Simon C, Pouta, Anneli, Province, Michael A, Psaty, Bruce M, Rathmann, Wolfgang, Rayner, Nigel W, Rice, Kenneth, Ripatti, Samuli, Rivadeneira, Fernando, Roden, Michael, Rolandsson, Olov, Sandbaek, Annelli, Sandhu, Manjinder, Sanna, Serena, Sayer, Avan Aihie, Scheet, Paul, Scott, Laura J, Seedorf, Udo, Sharp, Stephen J, Shields, Beverley, Sigurethsson, Gunnar, Sijbrands, Eric J G, Silveira, Angela, Simpson, Laila, Singleton, Andrew, Smith, Nicholas L, Sovio, Ulla, Swift, Amy, Syddall, Holly, Syvänen, Ann-Christine, Tanaka, Toshiko, Thorand, Barbara, Tichet, Jean, Tönjes, Anke, Tuomi, Tiinamaija, Uitterlinden, André G, van Dijk, Ko Willems, van Hoek, Mandy, Varma, Dhiraj, Visvikis-Siest, Sophie, Vitart, Veronique, Vogelzangs, Nicole, Waeber, Gérard, Wagner, Peter J, Walley, Andrew, Walters, G Bragi, Ward, Kim L, Watkins, Hugh, Weedon, Michael N, Wild, Sarah H, Willemsen, Gonneke, Witteman, Jaqueline C M, Yarnell, John W G, Zeggini, Eleftheria, Zelenika, Diana, Zethelius, Björn, Zhai, Guangju, Zhao, Jing Hua, Zillikens, M Carola, Borecki, Ingrid B, Loos, Ruth J F, Meneton, Pierre, Magnusson, Patrik K E, Nathan, David M, Williams, Gordon H, Hattersley, Andrew T, Silander, Kaisa, Salomaa, Veikko, Smith, George Davey, Bornstein, Stefan R, Schwarz, Peter, Spranger, Joachim, Karpe, Fredrik, Shuldiner, Alan R, Cooper, Cyrus, Dedoussis, George V, Serrano-Ríos, Manuel, Morris, Andrew D, Lind, Lars, Palmer, Lyle J, Hu, Frank B, Franks, Paul W, Ebrahim, Shah, Marmot, Michael, Kao, W H Linda, Pankow, James S, Sampson, Michael J, Kuusisto, Johanna, Laakso, Markku, Hansen, Torben, Pedersen, Oluf, Pramstaller, Peter Paul, Wichmann, H Erich, Illig, Thomas, Rudan, Igor, Wright, Alan F, Stumvoll, Michael, Campbell, Harry, Wilson, James F, Bergman, Richard N, Buchanan, Thomas A, Collins, Francis S, Mohlke, Karen L, Tuomilehto, Jaakko, Valle, Timo T, Altshuler, David, Rotter, Jerome I, Siscovick, David S, Penninx, Brenda W J H, Boomsma, Dorret I, Deloukas, Panos, Spector, Timothy D, Frayling, Timothy M, Ferrucci, Luigi, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari, van Duijn, Cornelia M, Aulchenko, Yurii S, Cao, Antonio, Scuteri, Angelo, Schlessinger, David, Uda, Manuela, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Waterworth, Dawn M, Vollenweider, Peter, Peltonen, Leena, Mooser, Vincent, Abecasis, Goncalo R, Wareham, Nicholas J, Sladek, Robert, Froguel, Philippe, Watanabe, Richard M, Meigs, James B, Groop, Leif, Boehnke, Michael, McCarthy, Mark I, Florez, Jose C, Barroso, Inês, Dupuis, Josée, Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Soranzo, Nicole, Jackson, Anne U, Wheeler, Eleanor, Glazer, Nicole L, Bouatia-Naji, Nabila, Gloyn, Anna L, Lindgren, Cecilia M, Mägi, Reedik, Morris, Andrew P, Randall, Joshua, Johnson, Toby, Elliott, Paul, Rybin, Denis, Thorleifsson, Gudmar, Steinthorsdottir, Valgerdur, Henneman, Peter, Grallert, Harald, Dehghan, Abbas, Hottenga, Jouke Jan, Franklin, Christopher S, Navarro, Pau, Song, Kijoung, Goel, Anuj, Perry, John R B, Egan, Josephine M, Lajunen, Taina, Grarup, Niels, Sparsø, Thomas, Doney, Alex, Voight, Benjamin F, Stringham, Heather M, Li, Man, Kanoni, Stavroula, Shrader, Peter, Cavalcanti-Proença, Christine, Kumari, Meena, Qi, Lu, Timpson, Nicholas J, Gieger, Christian, Zabena, Carina, Rocheleau, Ghislain, Ingelsson, Erik, An, Ping, O'Connell, Jeffrey, Luan, Jian'an, Elliott, Amanda, McCarroll, Steven A, Payne, Felicity, Roccasecca, Rosa Maria, Pattou, François, Sethupathy, Praveen, Ardlie, Kristin, Ariyurek, Yavuz, Balkau, Beverley, Barter, Philip, Beilby, John P, Ben-Shlomo, Yoav, Benediktsson, Rafn, Bennett, Amanda J, Bergmann, Sven, Bochud, Murielle, Boerwinkle, Eric, Bonnefond, Amélie, Bonnycastle, Lori L, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Bumpstead, Suzannah J, Charpentier, Guillaume, Chen, Yii-Der Ida, Chines, Peter, Clarke, Robert, Coin, Lachlan J M, Cooper, Matthew N, Cornelis, Marilyn, Crawford, Gabe, Crisponi, Laura, Day, Ian N M, de Geus, Eco J C, Delplanque, Jerome, Dina, Christian, Erdos, Michael R, Fedson, Annette C, Fischer-Rosinsky, Antje, Forouhi, Nita G, Fox, Caroline S, Frants, Rune, Franzosi, Maria Grazia, Galan, Pilar, Goodarzi, Mark O, Graessler, Jürgen, Groves, Christopher J, Grundy, Scott, Gwilliam, Rhian, Gyllensten, Ulf, Hadjadj, Samy, Hallmans, Göran, Hammond, Naomi, Han, Xijing, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hayward, Caroline, Heath, Simon C, Hercberg, Serge, Herder, Christian, Hicks, Andrew A, Hillman, David R, Hingorani, Aroon D, Hofman, Albert, Hui, Jennie, Hung, Joe, Isomaa, Bo, Johnson, Paul R V, Jørgensen, Torben, Jula, Antti, Kaakinen, Marika, Kaprio, Jaakko, Kesaniemi, Y Antero, Kivimaki, Mika, Knight, Beatrice, Koskinen, Seppo, Kovacs, Peter, Kyvik, Kirsten Ohm, Lathrop, G Mark, Lawlor, Debbie A, Le Bacquer, Olivier, Lecoeur, Cécile, Li, Yun, Lyssenko, Valeriya, Mahley, Robert, Mangino, Massimo, Manning, Alisa K, Martínez-Larrad, María Teresa, McAteer, Jarred B, McCulloch, Laura J, McPherson, Ruth, Meisinger, Christa, Melzer, David, Meyre, David, Mitchell, Braxton D, Morken, Mario A, 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Abstract

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.

Published
2010
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50. Correction: DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts

Author

Zhernakova, Daria V., primary, de Klerk, Eleonora, additional, Westra, Harm-Jan, additional, Mastrokolias, Anastasios, additional, Amini, Shoaib, additional, Ariyurek, Yavuz, additional, Jansen, Rick, additional, Penninx, Brenda W., additional, Hottenga, Jouke J., additional, Willemsen, Gonneke, additional, de Geus, Eco J., additional, Boomsma, Dorret I., additional, Veldink, Jan H., additional, van den Berg, Leonard H., additional, Wijmenga, Cisca, additional, den Dunnen, Johan T., additional, van Ommen, Gert-Jan B., additional, 't Hoen, Peter A. C., additional, and Franke, Lude, additional

Published
2013
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