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A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
- Source :
- PLoS ONE, 7(1):e29202. PUBLIC LIBRARY SCIENCE, Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, Sandy An, S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Posthuma, D, Penninx, B W J H & Sladek, R 2012, ' A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202, PLoS ONE, Vol 7, Iss 1, p e29202 (2012), PLoS ONE, 7(1), PLoS ONE, PLoS ONE, 7(1):e29202. Public Library of Science, PLoS ONE 7:e29202 (2012), DIAGRAM Consortium & MAGIC Investigators 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', P L o S One, vol. 7, no. 1, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202, Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, An, S S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Navarro, P, Rudan, I, Campbell, H, Wilson, J F, Hayward, C, Vitart, V & Wild, S H & Wright, A F 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202, pp. 1-14 . https://doi.org/10.1371/journal.pone.0029202, Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, An, S S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Langenberg, C, Hofmann, O M, Dupuis, J, Qi, L, Segrè, A V, van Hoek, M, Borch-Johnsen, K, Kyvik, K O & DIAGRAM Consortium 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', P L o S One, vol. 7, no. 1, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202, PLOS ONE, Plos One, vol. 7, no. 1, pp. e29202, PLoS ONE; Vol 7, Yarnell, J & Palmer, N D 2012, ' A Genome-wide association search for Type 2 Diabetes genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202 . https://doi.org/10.1371/journal.pone.0029202
- Publication Year :
- 2012
-
Abstract
- African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P
- Subjects :
- Netherlands Twin Register (NTR)
Male
Adult
African Americans/genetics
Aged
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2/ethnology
Diabetes Mellitus, Type 2/genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Meta-Analysis as Topic
Middle Aged
Polymorphism, Single Nucleotide
Validation Studies as Topic
Medicin och hälsovetenskap
Linkage disequilibrium
Genetic Screens
endocrine system diseases
lcsh:Medicine
Genome-wide association study
Medical and Health Sciences
0302 clinical medicine
Endocrinology
Genome Sequencing
lcsh:Science
Medicine(all)
Genetics
African Americans
0303 health sciences
education.field_of_study
INSULIN-RESISTANCE
Multidisciplinary
Agricultural and Biological Sciences(all)
LARGE-SCALE ASSOCIATION
STAGE RENAL-DISEASE
COMMON VARIANTS
Genomics
Medicine
Research Article
SUSCEPTIBILITY LOCI
General Science & Technology
Population
Single-nucleotide polymorphism
Biology
DIAGRAM Consortium
03 medical and health sciences
MAGIC Investigators
SDG 3 - Good Health and Well-being
Genetic linkage
MD Multidisciplinary
Genome-Wide Association Studies
SNP
ddc:610
education
Genotyping
030304 developmental biology
Diabetic Endocrinology
LINKAGE ANALYSIS
Biochemistry, Genetics and Molecular Biology(all)
lcsh:R
TCF7L2 GENE
Case-control study
Computational Biology
nutritional and metabolic diseases
Human Genetics
Diabetes Mellitus Type 2
Stage renal-disease
large-scale association
Susceptibility loci
Insulin-resistance
Fasting glucose
Tissue factor
Homeodomain protein
Linkage analysis
Common variants
TCF7L2 gene
Black or African American
Diabetes Mellitus, Type 2
TISSUE FACTOR
Genetics of Disease
HOMEODOMAIN PROTEIN
Genetic Polymorphism
lcsh:Q
Genome Expression Analysis
030217 neurology & neurosurgery
Population Genetics
FASTING GLUCOSE
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, 7(1):e29202. PUBLIC LIBRARY SCIENCE, Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, Sandy An, S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Posthuma, D, Penninx, B W J H & Sladek, R 2012, ' A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202, PLoS ONE, Vol 7, Iss 1, p e29202 (2012), PLoS ONE, 7(1), PLoS ONE, PLoS ONE, 7(1):e29202. Public Library of Science, PLoS ONE 7:e29202 (2012), DIAGRAM Consortium & MAGIC Investigators 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', P L o S One, vol. 7, no. 1, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202, Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, An, S S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Navarro, P, Rudan, I, Campbell, H, Wilson, J F, Hayward, C, Vitart, V & Wild, S H & Wright, A F 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202, pp. 1-14 . https://doi.org/10.1371/journal.pone.0029202, Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, An, S S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Langenberg, C, Hofmann, O M, Dupuis, J, Qi, L, Segrè, A V, van Hoek, M, Borch-Johnsen, K, Kyvik, K O & DIAGRAM Consortium 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', P L o S One, vol. 7, no. 1, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202, PLOS ONE, Plos One, vol. 7, no. 1, pp. e29202, PLoS ONE; Vol 7, Yarnell, J & Palmer, N D 2012, ' A Genome-wide association search for Type 2 Diabetes genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202 . https://doi.org/10.1371/journal.pone.0029202
- Accession number :
- edsair.doi.dedup.....373ffe21cfe482b2e100586455896d9e