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1. Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

Author: Ibanez, Laura, Heitsch, Laura, Carrera, Caty, Farias, Fabiana HG, Del Aguila, Jorge L, Dhar, Rajat, Budde, John, Bergmann, Kristy, Bradley, Joseph, Harari, Oscar, Phuah, Chia Ling, Lemmens, Robin, Viana Oliveira Souza, Alessandro A, Moniche, Francisco, Cabezas-Juan, Antonio, Arenillas, Juan Francisco, Krupinksi, Jerzy, Cullell, Natalia, Torres-Aguila, Nuria, Muiño, Elena, Cárcel-Márquez, Jara, Marti-Fabregas, Joan, Delgado-Mederos, Raquel, Marin-Bueno, Rebeca, Hornick, Alejandro, Vives-Bauza, Cristofol, Navarro, Rosa Diaz, Tur, Silvia, Jimenez, Carmen, Obach, Victor, Segura, Tomas, Serrano-Heras, Gemma, Chung, Jong Won, Roquer, Jaume, Soriano-Tarraga, Carol, Giralt-Steinhauer, Eva, Mola-Caminal, Marina, Pera, Joanna, Lapicka-Bodzioch, Katarzyna, Derbisz, Justyna, Davalos, Antoni, Lopez-Cancio, Elena, Muñoz, Lucia, Tatlisumak, Turgut, Molina, Carlos, Ribo, Marc, Bustamante, Alejandro, Sobrino, Tomas, Castillo-Sanchez, Jose, Campos, Francisco, Rodriguez-Castro, Emilio, Arias-Rivas, Susana, Rodríguez-Yáñez, Manuel, Herbosa, Christina, Ford, Andria L, Gutierrez-Romero, Alonso, Uribe-Pacheco, Rodrigo, Arauz, Antonio, Lopes-Cendes, Iscia, Lowenkopf, Theodore, Barboza, Miguel A, Amini, Hajar, Stamova, Boryana, Ander, Bradley P, Sharp, Frank R, Kim, Gyeong Moon, Bang, Oh Young, Jimenez-Conde, Jordi, Slowik, Agnieszka, Stribian, Daniel, Tsai, Ellen A, Burkly, Linda C, Montaner, Joan, Fernandez-Cadenas, Israel, Lee, Jin Moo, and Cruchaga, Carlos
Subjects: Epidemiology, Health Sciences, Human Genome, Stroke, Genetics, Brain Disorders, Biotechnology, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Neurological, Bayes Theorem, Brain Ischemia, Genome-Wide Association Study, Humans, Ischemic Stroke, United States, ischaemic stroke, neuroprotection, genetics, NIHSS, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences, Psychology
Abstract: During the first hours after stroke onset, neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between the National Institutes of Health Stroke Scale (NIHSS) within 6 h of stroke onset and NIHSS at 24 h. A total of 5876 individuals from seven countries (Spain, Finland, Poland, USA, Costa Rica, Mexico and Korea) were studied using a multi-ancestry meta-analyses. We found that 8.7% of NIHSS at 24 h of variance was explained by common genetic variations, and also that early neurological instability has a different genetic architecture from that of stroke risk. Eight loci (1p21.1, 1q42.2, 2p25.1, 2q31.2, 2q33.3, 5q33.2, 7p21.2 and 13q31.1) were genome-wide significant and explained 1.8% of the variability suggesting that additional variants influence early change in neurological deficits. We used functional genomics and bioinformatic annotation to identify the genes driving the association from each locus. Expression quantitative trait loci mapping and summary data-based Mendelian randomization indicate that ADAM23 (log Bayes factor = 5.41) was driving the association for 2q33.3. Gene-based analyses suggested that GRIA1 (log Bayes factor = 5.19), which is predominantly expressed in the brain, is the gene driving the association for the 5q33.2 locus. These analyses also nominated GNPAT (log Bayes factor = 7.64) ABCB5 (log Bayes factor = 5.97) for the 1p21.1 and 7p21.1 loci. Human brain single-nuclei RNA-sequencing indicates that the gene expression of ADAM23 and GRIA1 is enriched in neurons. ADAM23, a presynaptic protein and GRIA1, a protein subunit of the AMPA receptor, are part of a synaptic protein complex that modulates neuronal excitability. These data provide the first genetic evidence in humans that excitotoxicity may contribute to early neurological instability after acute ischaemic stroke.
Published: 2022

2. Clinical characterisation of patients in the post-acute stage of anti-NMDA receptor encephalitis: a prospective cohort study and comparison with patients with schizophrenia spectrum disorders

Author: Páramo, Dolores, Medrano, Vicente, Casado, Virginia, Guanyabens, Nicolau, Giné-Servén, Eloi, Ángeles del Real, María, Pardo, Javier, Martin-Gil, Leticia, Barrero-Hernández, Francisco Javier, García-Barragán, Nuria, Falip, Mercè, Simó, Marta, Rodríguez, Eloy, Ruiz Ezquerro, Juan José, Bataller, Luis, Safont, Gemma, Vicente-Hervàs, José, Brieva, Luis, Casado, Ignacio, Portilla, Juan Carlos, Escalante, Sònia, Arenillas, Juan Francisco, Erro, Elena, Jericó-Pascual, Ivonne, Fuerte-Hortigón, Alejandro, Morató, Alba, Saiz, Albert, Blanco, Yolanda, Sepúlveda, Maria, Ruiz, Raquel, Naranjo, Laura, Rodés, Maria, Aguilar, Esther, Alba, Mercè, Caballero, Eva, Guasp, Mar, Rosa-Justicia, Mireia, Muñoz-Lopetegi, Amaia, Martínez-Hernández, Eugenia, Armangué, Thais, Sugranyes, Gisela, Stein, Heike, Borràs, Roger, Prades, Laia, Ariño, Helena, Planagumà, Jesús, De-La-Serna, Elena, Escudero, Domingo, Llufriu, Sara, Sánchez-Valle, Raquel, Santamaria, Joan, Compte, Albert, Castro-Fornieles, Josefina, and Dalmau, Josep
Published: 2022
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3. Anosmia is associated with lower in-hospital mortality in COVID-19

Author: Talavera, Blanca, García-Azorín, David, Martínez-Pías, Enrique, Trigo, Javier, Hernández-Pérez, Isabel, Valle-Peñacoba, Gonzalo, Simón-Campo, Paula, de Lera, Mercedes, Chavarría-Miranda, Alba, López-Sanz, Cristina, Gutiérrez-Sánchez, María, Martínez-Velasco, Elena, Pedraza, María, Sierra, Álvaro, Gómez-Vicente, Beatriz, Guerrero, Ángel, and Arenillas, Juan Francisco
Published: 2020
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4. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author: Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera, José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.
Published: 2018
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5. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author: Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera., José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.
Published: 2018
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6. Embolic Events in Infective Endocarditis: A Comprehensive Review.

Author: Cabezon, Gonzalo, Pulido, Paloma, Díaz, Javier López, de Miguel-Álava, María, Vilacosta, Isidre, García-Azorin, David, Lozano, Adrian, Oña, Andrea, Arenillas, Juan Francisco, and Román, José-Alberto San
Abstract: Infective endocarditis (IE) is a life-threating entity with three main complications: heart failure (HF), uncontrolled infection (UI) and embolic events (EEs). HF and UI are the main indications of cardiac surgery and have been studied thoroughly. On the other hand, much more uncertainty surrounds EEs, which have an abrupt and somewhat unpredictable behaviour. EEs in the setting of IE have unique characteristics that must be explored, such as the potential of hemorrhagic transformation of stroke. Accurately predicting which patients will suffer EEs seems to be pivotal to achieve an optimal management of the disease, but this complex process is still not completely understood. The indication of cardiac surgery in order to prevent EEs in the absence of HF or UI is in question as scientific evidence is controversial and mainly of a retrospective nature. This revision addresses these topics and try to summarize the evidence and recommendations about them. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Investigating the Prognostic Role of Peripheral Inflammatory Markers in Mild Cognitive Impairment

Author: Tondo, Giacomo, primary, Aprile, Davide, additional, De Marchi, Fabiola, additional, Sarasso, Barbara, additional, Serra, Paola, additional, Borasio, Giordana, additional, Rojo, Esther, additional, Arenillas, Juan Francisco, additional, and Comi, Cristoforo, additional
Published: 2023
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8. Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Author: Trigo, Javier, García-Azorín, David, Planchuelo-Gómez, Álvaro, Martínez-Pías, Enrique, Talavera, Blanca, Hernández-Pérez, Isabel, Valle-Peñacoba, Gonzalo, Simón-Campo, Paula, de Lera, Mercedes, Chavarría-Miranda, Alba, López-Sanz, Cristina, Gutiérrez-Sánchez, María, Martínez-Velasco, Elena, Pedraza, María, Sierra, Álvaro, Gómez-Vicente, Beatriz, Arenillas, Juan Francisco, and Guerrero, Ángel L.
Published: 2020
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9. Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

Author: Carrera, Caty, Cullell, Natalia, Torres-Águila, Nuria, Muiño, Elena, Bustamante, Alejandro, Dávalos, Antonio, López-Cancio, Elena, Ribó, Marc, Molina, Carlos A., Giralt-Steinhauer, Eva, Soriano-Tárraga, Carolina, Mola-Caminal, Marina, Jiménez-Conde, Jordi, Roquer, Jaume, Vives-Bauza, Cristófol, Navarro, Rosa Díaz, Obach, Victor, Arenillas, Juan Francisco, Segura, Tomás, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Freijo, Marimar, Cabezas, Juan Antonio, Tatlisumak, Turgut, Heitsch, Laura, Ibañez, Laura, Cruchaga, Carlos, Lee, Jin-Moo, Strbian, Daniel, Montaner, Joan, and Fernández-Cadenas, Israel
Published: 2019
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10. Intracranial atherosclerotic plaque enhancement and long‐term risk of future strokes: A prospective, longitudinal study

Author: Gómez‐Vicente, Beatriz, primary, Hernández‐Pérez, María, additional, Martínez‐Velasco, Elena, additional, Rodríguez‐Velasco, Margarita, additional, Munuera, Josep, additional, Rubiera, Marta, additional, Vert, Carla, additional, Dorado, Laura, additional, de Lera, Mercedes, additional, Calleja, Ana Isabel, additional, Cortijo, Elisa, additional, Agulla, Jesús, additional, López‐Cancio, Elena, additional, and Arenillas, Juan Francisco, additional
Published: 2022
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11. Clinical characterisation of patients in the post-acute stage of anti-NMDA receptor encephalitis: a prospective cohort study and comparison with patients with schizophrenia spectrum disorders

Author: Guasp, Mar, primary, Rosa-Justicia, Mireia, additional, Muñoz-Lopetegi, Amaia, additional, Martínez-Hernández, Eugenia, additional, Armangué, Thais, additional, Sugranyes, Gisela, additional, Stein, Heike, additional, Borràs, Roger, additional, Prades, Laia, additional, Ariño, Helena, additional, Planagumà, Jesús, additional, De-La-Serna, Elena, additional, Escudero, Domingo, additional, Llufriu, Sara, additional, Sánchez-Valle, Raquel, additional, Santamaria, Joan, additional, Compte, Albert, additional, Castro-Fornieles, Josefina, additional, Dalmau, Josep, additional, Páramo, Dolores, additional, Medrano, Vicente, additional, Casado, Virginia, additional, Guanyabens, Nicolau, additional, Giné-Servén, Eloi, additional, Ángeles del Real, María, additional, Pardo, Javier, additional, Martin-Gil, Leticia, additional, Barrero-Hernández, Francisco Javier, additional, García-Barragán, Nuria, additional, Falip, Mercè, additional, Simó, Marta, additional, Rodríguez, Eloy, additional, Ruiz Ezquerro, Juan José, additional, Bataller, Luis, additional, Safont, Gemma, additional, Vicente-Hervàs, José, additional, Brieva, Luis, additional, Casado, Ignacio, additional, Portilla, Juan Carlos, additional, Escalante, Sònia, additional, Arenillas, Juan Francisco, additional, Erro, Elena, additional, Jericó-Pascual, Ivonne, additional, Fuerte-Hortigón, Alejandro, additional, Morató, Alba, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, Sepúlveda, Maria, additional, Ruiz, Raquel, additional, Naranjo, Laura, additional, Rodés, Maria, additional, Aguilar, Esther, additional, Alba, Mercè, additional, and Caballero, Eva, additional
Published: 2022
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12. Editorial: Understanding stroke recovery to improve outcomes: From acute care to chronic rehabilitation

Author: Conforto, Adriana Bastos, primary, Liew, Sook-Lei, additional, Luft, Andreas R., additional, Kitago, Tomoko, additional, Bernhardt, Julie, additional, and Arenillas, Juan Francisco, additional
Published: 2022
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13. A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype

Author: Cárcel-Márquez, Jara, primary, Muiño, Elena, additional, Gallego-Fabrega, Cristina, additional, Cullell, Natalia, additional, Lledós, Miquel, additional, Llucià-Carol, Laia, additional, Sobrino, Tomás, additional, Campos, Francisco, additional, Castillo, José, additional, Freijo, Marimar, additional, Arenillas, Juan Francisco, additional, Obach, Victor, additional, Álvarez-Sabín, José, additional, Molina, Carlos A., additional, Ribó, Marc, additional, Jiménez-Conde, Jordi, additional, Roquer, Jaume, additional, Muñoz-Narbona, Lucia, additional, Lopez-Cancio, Elena, additional, Millán, Mònica, additional, Diaz-Navarro, Rosa, additional, Vives-Bauza, Cristòfol, additional, Serrano-Heras, Gemma, additional, Segura, Tomás, additional, Ibañez, Laura, additional, Heitsch, Laura, additional, Delgado, Pilar, additional, Dhar, Rajat, additional, Krupinski, Jerzy, additional, Delgado-Mederos, Raquel, additional, Prats-Sánchez, Luis, additional, Camps-Renom, Pol, additional, Blay, Natalia, additional, Sumoy, Lauro, additional, de Cid, Rafael, additional, Montaner, Joan, additional, Cruchaga, Carlos, additional, Lee, Jin-Moo, additional, Martí-Fàbregas, Joan, additional, and Férnandez-Cadenas, Israel, additional
Published: 2022
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14. Thalamic diffusion differences related to cognitive function in white matter lesions

Author: Fernández-Andújar, Marina, Soriano-Raya, Juan José, Miralbell, Júlia, López-Cancio, Elena, Cáceres, Cynthia, Bargalló, Núria, Barrios, Maite, Arenillas, Juan Francisco, Toran, Pere, Alzamora, Maite, Clemente, Imma, Dávalos, Antoni, and Mataró, Maria
Published: 2014
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15. Stroke genetics informs drug discovery and risk prediction across ancestries

Author: Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie, Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie
Abstract: Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
Published: 2022

16. Editorial: Understanding stroke recovery to improve outcomes: From acute care to chronic rehabilitation

Author: Conforto, Adriana Bastos, Liew, Sook-Lei, Luft, Andreas R; https://orcid.org/0000-0001-9865-7382, Kitago, Tomoko; https://orcid.org/0000-0003-0222-6698, Bernhardt, Julie, Arenillas, Juan Francisco, Conforto, Adriana Bastos, Liew, Sook-Lei, Luft, Andreas R; https://orcid.org/0000-0001-9865-7382, Kitago, Tomoko; https://orcid.org/0000-0003-0222-6698, Bernhardt, Julie, and Arenillas, Juan Francisco
Published: 2022

17. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

Author: Fernández-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafria, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado, Pilar, Ribó, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Marimar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez-Sabín, José, Molina, Carlos A., Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Perez de la Ossa, Natalia, Martinez-Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Canovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Davalos, Antoni, Roquer, Jaume, Arenillas, Juan Francisco, Martí-Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, and Montaner, Joan
Published: 2017
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18. Intracranial atherosclerotic plaque enhancement and long‐term risk of future strokes: A prospective, longitudinal study.

Author: Gómez‐Vicente, Beatriz, Hernández‐Pérez, María, Martínez‐Velasco, Elena, Rodríguez‐Velasco, Margarita, Munuera, Josep, Rubiera, Marta, Vert, Carla, Dorado, Laura, de Lera, Mercedes, Calleja, Ana Isabel, Cortijo, Elisa, Agulla, Jesús, López‐Cancio, Elena, and Arenillas, Juan Francisco
Subjects: STROKE, ATHEROSCLEROTIC plaque, TRANSIENT ischemic attack, RECEIVER operating characteristic curves, ASYMPTOMATIC patients
Abstract: Background and Purpose: The prognostic significance of postcontrast enhancement of intracranial atheromatous plaque is uncertain. Prospective, long‐term follow‐up studies in Caucasians, using a multicenter design, are lacking. We aimed to evaluate whether this radiological sign predicts long‐term new stroke in symptomatic and asymptomatic intracranial atherosclerotic disease (ICAD) patients. Methods: This was a prospective, observational, longitudinal, multicenter study. We included a symptomatic and an asymptomatic cohort of ICAD patients that underwent 3T MRI including high‐resolution sequences focused on the atheromatous plaque. We evaluated grade of stenosis, plaque characteristics, and gadolinium enhancement ratio (postcontrast plaque signal/postcontrast corpus callosum signal). The occurrence of new events was evaluated at 3, 6, 9, and 12 months and annually thereafter. The association between plaque characteristics and new stroke was studied using Cox multiple regression survival analysis and Kaplan‐Meier curves. Results: Forty‐eight symptomatic and 13 asymptomatic patients were included. During 56.3 ± 16.9 months, 11 patients (18%) suffered a new event (seven ischemic, two hemorrhagic, and two transient ischemic attacks). A receiver operating characteristic curve identified an enhancement ratio of >1.77 to predict a new event. In a multivariable Cox regression, postcontrast enhancement ratio >1.77 (hazard ratio [HR]= 3.632; 95% confidence interval [CI], 1.082‐12.101) and cerebral microbleeds (HR = 5.244; 95% CI, 1.476‐18.629) were independent predictors of future strokes. Patients with a plaque enhancement ratio >1.77 had a lower survival free of events (p <.05). Conclusions: High intracranial postcontrast enhancement is a long‐term predictor of new stroke in ICAD patients. Further studies are needed to elucidate whether postcontrast enhancement reflects inflammatory activity of intracranial atheromatous plaque. [ABSTRACT FROM AUTHOR]
Published: 2023
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19. Editorial: Understanding stroke recovery to improve outcomes: From acute care to chronic rehabilitation.

Author: Bastos Conforto, Adriana, Sook-Lei Liew, Luft, Andreas R., Tomoko Kitago, Bernhardt, Julie, and Arenillas, Juan Francisco
Subjects: REHABILITATION
Published: 2022
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20. Tract-Specific Fractional Anisotropy Predicts Cognitive Outcome in a Community Sample of Middle-Aged Participants with White Matter Lesions

Author: Soriano-Raya, Juan José, Miralbell, Júlia, López-Cancio, Elena, Bargalló, Núria, Arenillas, Juan Francisco, Barrios, Maite, Cáceres, Cynthia, Toran, Pere, Alzamora, Maite, Dávalos, Antoni, and Mataró, Maria
Published: 2014
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21. Relative Cerebral Blood Volume as a Marker of Durable Tissue-at-Risk Viability in Hyperacute Ischemic Stroke

Author: Cortijo, Elisa, Calleja, Ana Isabel, García-Bermejo, Pablo, Mulero, Patricia, Pérez-Fernández, Santiago, Reyes, Javier, Muñoz, M Fe, Martínez-Galdámez, Mario, and Arenillas, Juan Francisco
Published: 2014
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22. Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma

Author: Carrera, Caty, primary, Cárcel-Márquez, Jara, additional, Cullell, Natalia, additional, Torres-Águila, Nuria, additional, Muiño, Elena, additional, Castillo, José, additional, Sobrino, Tomás, additional, Campos, Francisco, additional, Rodríguez-Castro, Emilio, additional, Llucià-Carol, Laia, additional, Millán, Mònica, additional, Muñoz-Narbona, Lucía, additional, López-Cancio, Elena, additional, Bustamante, Alejandro, additional, Ribó, Marc, additional, Álvarez-Sabín, José, additional, Jiménez-Conde, Jordi, additional, Roquer, Jaume, additional, Giralt-Steinhauer, Eva, additional, Soriano-Tárraga, Carolina, additional, Mola-Caminal, Marina, additional, Vives-Bauza, Cristófol, additional, Navarro, Rosa Díaz, additional, Tur, Silvia, additional, Obach, Victor, additional, Arenillas, Juan Francisco, additional, Segura, Tomás, additional, Serrano-Heras, Gemma, additional, Martí-Fàbregas, Joan, additional, Delgado-Mederos, Raquel, additional, Freijo-Guerrero, M Mar, additional, Moniche, Francisco, additional, Cabezas, Juan Antonio, additional, Castellanos, Mar, additional, Gallego-Fabrega, Cristina, additional, González-Sanchez, Jonathan, additional, Krupinsky, Jurek, additional, Strbian, Daniel, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Lemmens, Robin, additional, Slowik, Agnieszka, additional, Pera, Johanna, additional, Kittner, Steven, additional, Cole, John, additional, Heitsch, Laura, additional, Ibañez, Laura, additional, Cruchaga, Carlos, additional, Lee, Jin-Moo, additional, Montaner, Joan, additional, and Fernández-Cadenas, Israel, additional
Published: 2021
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23. Neurological symptoms in Covid‐19 patients in the emergency department

Author: García‐Azorín, David, primary, Trigo, Javier, additional, Martínez‐Pías, Enrique, additional, Hernández‐Pérez, Isabel, additional, Valle‐Peñacoba, Gonzalo, additional, Talavera, Blanca, additional, Simón‐Campo, Paula, additional, Lera, Mercedes, additional, Chavarría‐Miranda, Alba, additional, López‐Sanz, Cristina, additional, Gutiérrez‐Sánchez, María, additional, Martínez‐Velasco, Elena, additional, Pedraza, María, additional, Sierra, Álvaro, additional, Gómez‐Vicente, Beatriz, additional, Guerrero, Ángel, additional, and Arenillas, Juan Francisco, additional
Published: 2021
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24. Cognitive Patterns in Relation to Biomarkers of Cerebrovascular Disease and Vascular Risk Factors

Author: Miralbell, Júlia, López-Cancio, Elena, López-Oloriz, Jorge, Arenillas, Juan Francisco, Barrios, Maite, Soriano-Raya, Juan José, Galán, Amparo, Cáceres, Cynthia, Alzamora, Maite, Pera, Guillem, Toran, Pere, Dávalos, Antoni, and Mataró, Maria
Published: 2013
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25. Additional file 1 of Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Author: Trigo, Javier, García-Azorín, David, Planchuelo-Gómez, Álvaro, Martínez-Pías, Enrique, Talavera, Blanca, Hernández-Pérez, Isabel, Valle-Peñacoba, Gonzalo, Simón-Campo, Paula, Lera, Mercedes De, Chavarría-Miranda, Alba, López-Sanz, Cristina, Gutiérrez-Sánchez, María, Martínez-Velasco, Elena, Pedraza, María, Sierra, Álvaro, Gómez-Vicente, Beatriz, Arenillas, Juan Francisco, and Guerrero, Ángel L.
Abstract: Additional file 1: Summary of the screening proccess.
Published: 2020
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26. Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke

Author: Ibanez, Laura, primary, Heitsch, Laura, additional, Carrera, Caty, additional, Farias, Fabiana H.G., additional, Dhar, Rajat, additional, Budde, John, additional, Bergmann, Kristy, additional, Bradley, Joseph, additional, Harari, Oscar, additional, Phuah, Chia-Ling, additional, Lemmens, Robin, additional, Oliveira Souza, Alessandro A. Viana, additional, Moniche, Francisco, additional, Cabezas-Juan, Antonio, additional, Arenillas, Juan Francisco, additional, Krupinksi, Jerzy, additional, Cullell, Natalia, additional, Torres-Aguila, Nuria, additional, Muiño, Elena, additional, Cárcel-Márquez, Jara, additional, Marti-Fabregas, Joan, additional, Delgado-Mederos, Raquel, additional, Marin-Bueno, Rebeca, additional, Hornick, Alejandro, additional, Vives-Bauza, Cristofol, additional, Navarro, Rosa Diaz, additional, Tur, Silvia, additional, Jimenez, Carmen, additional, Obach, Victor, additional, Segura, Tomas, additional, Serrano-Heras, Gemma, additional, Chung, Jong-Won, additional, Roquer, Jaume, additional, Soriano-Tarraga, Carol, additional, Giralt-Steinhauer, Eva, additional, Mola-Caminal, Marina, additional, Pera, Joanna, additional, Lapicka-Bodzioch, Katarzyna, additional, Derbisz, Justyna, additional, Davalos, Antoni, additional, Lopez-Cancio, Elena, additional, Muñoz, Lucia, additional, Tatlisumak, Turgut, additional, Molina, Carlos, additional, Ribo, Marc, additional, Bustamante, Alejandro, additional, Sobrino, Tomas, additional, Castillo-Sanchez, Jose, additional, Campos, Francisco, additional, Rodriguez-Castro, Emilio, additional, Arias-Rivas, Susana, additional, Rodríguez-Yáñez, Manuel, additional, Herbosa, Christina, additional, Ford, Andria L., additional, Arauz, Antonio, additional, Lopes-Cendes, Iscia, additional, Lowenkopf, Theodore, additional, Barboza, Miguel A., additional, Amini, Hajar, additional, Stamova, Boryana, additional, Ander, Bradley P., additional, Sharp, Frank R, additional, Kim, Gyeong Moon, additional, Bang, Oh Young, additional, Jimenez-Conde, Jordi, additional, Slowik, Agnieszka, additional, Stribian, Daniel, additional, Tsai, Ellen A., additional, Burkly, Linda C., additional, Montaner, Joan, additional, Fernandez-Cadenas, Israel, additional, Lee, Jin-Moo, additional, and Cruchaga, Carlos, additional
Published: 2020
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27. Biological Signatures of Asymptomatic Extra- and Intracranial Atherosclerosis: The Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) Study

Author: López-Cancio, Elena, Galán, Amparo, Dorado, Laura, Jiménez, Marta, Hernández, María, Millán, Mónica, Reverté, Silvia, Suñol, Anna, Barallat, Jaume, Massuet, Anna, Alzamora, Maria Teresa, Dávalos, Antonio, and Arenillas, Juan Francisco
Published: 2012
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28. Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance

Author: Lamonja-Vicente, Noemí, primary, Dacosta-Aguayo, Rosalia, additional, López-Olóriz, Jorge, additional, Prades-Senovilla, Laia, additional, Roig-Coll, Francesca, additional, Castells-Sánchez, Alba, additional, Soriano-Raya, Juan José, additional, Clemente, Inmaculada, additional, Miralbell, Júlia, additional, Barrios, Maite, additional, López-Cancio, Elena, additional, Cáceres, Cynthia, additional, Arenillas, Juan Francisco, additional, Millán, Mónica, additional, Torán, Pere, additional, Pera, Guillem, additional, Fores, Rosa, additional, Alzamora, Maria Teresa, additional, Mataró, Maria, additional, and Via, Marc, additional
Published: 2020
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29. Neurological Comorbidity Is a Predictor of Death in Covid-19 Disease: A Cohort Study on 576 Patients

Author: García-Azorín, David, primary, Martínez-Pías, Enrique, additional, Trigo, Javier, additional, Hernández-Pérez, Isabel, additional, Valle-Peñacoba, Gonzalo, additional, Talavera, Blanca, additional, Simón-Campo, Paula, additional, de Lera, Mercedes, additional, Chavarría-Miranda, Alba, additional, López-Sanz, Cristina, additional, Gutiérrez-Sánchez, María, additional, Martínez-Velasco, Elena, additional, Pedraza, María, additional, Sierra, Álvaro, additional, Gómez-Vicente, Beatriz, additional, Guerrero, Ángel, additional, Ezpeleta, David, additional, Peñarrubia, María Jesús, additional, Gómez-Herreras, Jose Ignacio, additional, Bustamante-Munguira, Elena, additional, Abad-Molina, Cristina, additional, Orduña-Domingo, Antonio, additional, Ruiz-Martin, Guadalupe, additional, Jiménez-Cuenca, María Isabel, additional, Juarros, Santiago, additional, del Pozo-Vegas, Carlos, additional, Dueñas-Gutierrez, Carlos, additional, de Paula, Jose María Prieto, additional, Cantón-Álvarez, Belén, additional, Vicente, Jose Manuel, additional, and Arenillas, Juan Francisco, additional
Published: 2020
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30. Third Ventricle Width Assessed by Transcranial Sonography as Predictor of Long-Term Cognitive Impairment

Author: Crespo-Cuevas, Ane Miren, primary, López-Cancio, Elena, additional, Cáceres, Cynthia, additional, González, Anna, additional, Ispierto, Lourdes, additional, Hernández-Pérez, María, additional, Mataró, María, additional, Planas, Anna, additional, Canento, Tamara, additional, Martín, Lorena, additional, Arenillas, Juan Francisco, additional, Alvarez, Ramiro, additional, and Vilas, Dolores, additional
Published: 2020
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31. Structural brain changes and cognition in relation to markers of vascular dysfunction

Author: Miralbell, Julia, Soriano, Juan José, Spulber, Gabriela, López-Cancio, Elena, Arenillas, Juan Francisco, Bargalló, Núria, Galán, Amparo, Barrios, Maria Teresa, Cáceres, Cynthia, Alzamora, Maria Teresa, Pera, Guillem, Kivipelto, Miia, Wahlund, Lars-Olof, Dávalos, Antoni, and Mataró, Maria
Published: 2012
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32. Age- and Sex-Specific Risk Profiles and In-Hospital Mortality in 13,932 Spanish Stroke Patients

Author: Purroy, Francisco, primary, Vena, Ana, additional, Forné, Carles, additional, de Arce, Ana María, additional, Dávalos, Antonio, additional, Fuentes, Blanca, additional, Arenillas, Juan Francisco, additional, Krupinski, Jerzy, additional, Gómez-Choco, Manuel, additional, Palomeras, Ernest, additional, Martí-Fábregas, Joan, additional, Castillo, José, additional, Ustrell, Xavier, additional, Tejada, Javier, additional, Masjuan, Jaime, additional, Garcés, Moisés, additional, Benabdelhak, Ikram, additional, and Serena, Joaquin, additional
Published: 2019
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33. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author: Contreras Muruaga, M.M., primary, Reig, G., additional, Vivancos, J., additional, González, A., additional, Cardona, P., additional, Ramírez-Moreno, J.M., additional, Martí-Fábregas, J., additional, Suárez Fernández, C., additional, Pose, Antonio, additional, Díaz, José Antonio, additional, Rodríguez, Manuel, additional, Pena, Marta, additional, Arias, Susana, additional, Larrosa, Davinia, additional, González, Álvaro, additional, Rodríguez, Elisa, additional, González, Montserrat, additional, Fernández, Dolores, additional, Barbagelata, Cristina, additional, Raña, Natividad, additional, Freire, Santiago, additional, Cerqueiro, J. Manuel, additional, Guerrero, Héctor, additional, Ramos, Laura, additional, Álvarez, Leticia, additional, de Lis, José M., additional, Caro, Carmen, additional, Seijo, Manuel, additional, Mederer, Susana, additional, de Zarraga, Miguel Alberto, additional, Ferreiro, José, additional, Terrero, José M., additional, Arias, Mónica, additional, Pérez, Roberto, additional, Sánchez, Joaquín, additional, Maciñeiras, José, additional, Fernández, Julián, additional, Jaén, Fernando, additional, Esteva, David, additional, Zamora, Mónica, additional, Navarrete, Nuria, additional, García, Javier, additional, Mérida, Luis, additional, Corrales, Miguel Ángel, additional, Quirós, Raúl, additional, Cantero, Jesús, additional, Barrero, Francisco Javier, additional, Villegas, Inmaculada, additional, Castro, José, additional, Foronda, Jesús, additional, Carrillo, Dionisio, additional, Vega, Jesús, additional, Trujillo, José Antonio, additional, Montero, Manuel, additional, Jurado, Ana, additional, Sánchez, Carlos, additional, Agüera-Morales, Eduardo, additional, Sánchez, María, additional, Durán, Purificación, additional, Fernández de la Puerta, Rafael, additional, Pérez de la Blanca, María, additional, Martínez, María Paz, additional, Fernández, Óscar, additional, Tamayo, José Antonio, additional, Bustamante, Rafael, additional, Serrano, Pedro Jesús, additional, Arjona, Antonio, additional, Fernández, Javier, additional, Payan, Manuel, additional, Gómez, Ricardo, additional, Peña, Daniel, additional, Cabrerizo, Enrique, additional, Salgado, Fernando, additional, Ivanova Georgieva, Radka, additional, Gil-Núñez, Antonio, additional, Bello, Elena, additional, Díaz, Fernando, additional, Medina, Antonio, additional, Castellano, Ana, additional, Miranda, Yesica, additional, Fabre, Óscar, additional, García Polo, Iluminada, additional, Ibáñez, Patricia, additional, Sainz, Clara, additional, Sierra, Fernando, additional, Aragón, Esther, additional, Díaz, Jaime, additional, Aguilar, Fernando, additional, Ortega, María Ángeles, additional, Egido, José Antonio, additional, Pontes, José Carlos, additional, García, Miguel Ángel, additional, Cabrera, Francisco, additional, Batalla, Blanca, additional, Culla, Alex, additional, Molina, Carlos, additional, Flores, Alan, additional, Seró, Laia, additional, Muchada, Marian, additional, Meler, Pilar, additional, Boned-Riera, Sandra, additional, Cánovas, David, additional, Estela, Jordi, additional, Font, Juli, additional, Purroy, Francisco, additional, Benabdelhak, Ikram, additional, Sanahuja, Jordi, additional, Roquer, Jaume, additional, Rodríguez, Ana, additional, Ois, Ángel, additional, Cuadrado, Elisa, additional, Jiménez, Jordi, additional, Nogués, Xavier, additional, Kuprinski, Jerzy, additional, German, Antoni, additional, Irigoyen, Daniel, additional, Cara, Juan José, additional, Font, Maria Àngels, additional, Huertas, Sonia, additional, Martínez-Domeño, Alejandro, additional, Arroyo, Juan Antonio, additional, Delgado-Mederos, Raquel, additional, Gómez-Choco, Manuel Jesús, additional, Mengual, Juan José, additional, García, Sonia M., additional, Castellanos, M. del Mar, additional, van Eedenburg, Cecile, additional, Cañas, Imma, additional, Espinosa, Jordi, additional, Montull, Santiago, additional, Quesada, Helena, additional, Ustrell, Xavier, additional, Homedes, Christian, additional, Navalpotro, Irene, additional, Casanova, Jordi, additional, Lago, Aida Pilar, additional, Morata, Carmen, additional, Gorriz, David, additional, Moreno, Iván, additional, Tembl, José, additional, Ponz, Alejandro, additional, Fonseca, M. José, additional, Chamarro, Raquel, additional, Gil, Rosario, additional, Oliver, Vicente, additional, Pampliega, Ana, additional, Artero, Arturo, additional, Puchades, Francesc, additional, Landete, Lamberto, additional, Vilar, Carlos, additional, Jiménez, Carmen, additional, Vives, Bárbara, additional, Moragues, M. Dolores, additional, Díaz, Rosa, additional, Tur, Silvia, additional, Escribano, José Bernardo, additional, Lucas, César, additional, Martínez, Francisco, additional, Pons, José Miguel, additional, Romero, Amparo, additional, García, David, additional, Pérez, José, additional, Villaverde, Ramón, additional, Martínez, Salvadora, additional, Rodríguez, Aida, additional, Tejero, Carlos, additional, Pérez, Cristina, additional, Mostacero, Enrique, additional, Fernández, Covadonga, additional, Luna, Alain, additional, Pérez, Tomás, additional, González, Félix, additional, de Arce, Ana, additional, Martínez, Maite, additional, Díez, Noemí, additional, Gállego, Jaime, additional, Zandio, Beatriz, additional, Herrera, María, additional, Aymerich, Nuria, additional, Muñoz, Roberto, additional, Marta, Javier, additional, Artal, Jorge, additional, Errea, José M., additional, Timiraos, Juan José, additional, Moreno, M. Pilar, additional, Freijo, Mar, additional, García, Juan Manuel, additional, Gil, M. Carmen, additional, Revilla, M. Ángeles, additional, Palacio, Enrique, additional, Vázquez, José Luis, additional, Bestué, María, additional, Latorre, Ana, additional, Calvo, Eva, additional, Ballester, Laura, additional, Serrano, Marta, additional, Juega, Jesús M., additional, López, M. Ángeles, additional, Irimia, Pablo, additional, Imaz, Laura, additional, Fuentes, Blanca, additional, Sanz, Borja Enrique, additional, Beltrán, Luis, additional, Ruiz, Gerardo, additional, Martínez, Patricia, additional, Sánchez, Demetrio, additional, Barroso, Emilio, additional, Molina, Igor, additional, Budiño, Marco Antonio, additional, Masjuan, Jaime, additional, de Felipe, Alicia, additional, Matute, Consuelo, additional, Tejada, Javier, additional, Morán, Alberto, additional, Fernández, Esther, additional, Riveira, M. del Carmen, additional, Carnedo, Joaquín, additional, Manquillo, Antonio, additional, González, Raquel, additional, Fernández, José Carlos, additional, Guillan, Marta, additional, Yebra, Miguel, additional, Trejo, José M., additional, Saiz, Jesús, additional, Martínez-Acitores, Juan Carlos, additional, Bravo, Yolanda, additional, Arenillas, Juan Francisco, additional, Calleja, Ana, additional, Cortijo, Elisa, additional, Reyes, Javier, additional, López, Luis, additional, Muñoz, Pedro Luis, additional, Fidalgo, M. Ángeles, additional, Hernández, Jacinto, additional, Gómez, José Carlos, additional, Morán, José Carlos, additional, Gonzalo, Sonia, additional, Marrero, Jorge, additional, Satué, José Ángel, additional, Belinchón, Juan Carlos, additional, Moniche, Francisco, additional, Calderón, Enrique, additional, Escudero, Irene, additional, de la Torre, Javier, additional, Casado, Ignacio, additional, Antón, Joaquín, additional, Portilla, Juan Carlos, additional, Luengo, Juan, additional, Rosal, Joan, additional, Calzado, Elena, additional, Anglada, Juan Carlos, additional, Girón, Juan, additional, Ramírez, José M., additional, Pijierro, Agustín, additional, Roa, Ana, additional, Romero, Jorge, additional, Aguayo, Mariano, additional, Borrachero, Cristina, additional, Sanz, Gema, additional, Gómez, M. José, additional, Rico, Miguel Ángel, additional, Cayon, Antonio, additional, Carmona, Eduardo, additional, Cerro, Román, additional, López, Rafael, additional, Aguirre, Alfonso, additional, Lozano, Francisco, additional, and Rivera, José M., additional
Published: 2018
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34. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author: Contreras Muruaga, M.M., primary, Reig, G., additional, Vivancos, J., additional, González, A., additional, Cardona, P., additional, Ramírez-Moreno, J.M., additional, Martí-Fábregas, J., additional, Suárez Fernández, C., additional, Pose, Antonio, additional, Díaz, José Antonio, additional, Rodríguez, Manuel, additional, Pena, Marta, additional, Arias, Susana, additional, Larrosa, Davinia, additional, González, Álvaro, additional, Rodríguez, Elisa, additional, González, Montserrat, additional, Fernández, Dolores, additional, Barbagelata, Cristina, additional, Raña, Natividad, additional, Freire, Santiago, additional, Cerqueiro, J. Manuel, additional, Guerrero, Héctor, additional, Ramos, Laura, additional, Álvarez, Leticia, additional, de Lis, José M., additional, Caro, Carmen, additional, Seijo, Manuel, additional, Mederer, Susana, additional, de Zarraga, Miguel Alberto, additional, Ferreiro, José, additional, Terrero, José M., additional, Arias, Mónica, additional, Pérez, Roberto, additional, Sánchez, Joaquín, additional, Maciñeiras, José, additional, Fernández, Julián, additional, Jaén, Fernando, additional, Esteva, David, additional, Zamora, Mónica, additional, Navarrete, Nuria, additional, García, Javier, additional, Mérida, Luis, additional, Corrales, Miguel Ángel, additional, Quirós, Raúl, additional, Cantero, Jesús, additional, Barrero, Francisco Javier, additional, Villegas, Inmaculada, additional, Castro, José, additional, Foronda, Jesús, additional, Carrillo, Dionisio, additional, Vega, Jesús, additional, Trujillo, José Antonio, additional, Montero, Manuel, additional, Jurado, Ana, additional, Sánchez, Carlos, additional, Agüera-Morales, Eduardo, additional, Sánchez, María, additional, Durán, Purificación, additional, Fernández de la Puerta, Rafael, additional, Pérez de la Blanca, María, additional, Martínez, María Paz, additional, Fernández, Óscar, additional, Tamayo, José Antonio, additional, Bustamante, Rafael, additional, Serrano, Pedro Jesús, additional, Arjona, Antonio, additional, Fernández, Javier, additional, Payan, Manuel, additional, Gómez, Ricardo, additional, Peña, Daniel, additional, Cabrerizo, Enrique, additional, Salgado, Fernando, additional, Ivanova Georgieva, Radka, additional, Gil-Núñez, Antonio, additional, Bello, Elena, additional, Díaz, Fernando, additional, Medina, Antonio, additional, Castellano, Ana, additional, Miranda, Yesica, additional, Fabre, Óscar, additional, García Polo, Iluminada, additional, Ibáñez, Patricia, additional, Sainz, Clara, additional, Sierra, Fernando, additional, Aragón, Esther, additional, Díaz, Jaime, additional, Aguilar, Fernando, additional, Ortega, María Ángeles, additional, Egido, José Antonio, additional, Pontes, José Carlos, additional, García, Miguel Ángel, additional, Cabrera, Francisco, additional, Batalla, Blanca, additional, Culla, Alex, additional, Molina, Carlos, additional, Flores, Alan, additional, Seró, Laia, additional, Muchada, Marian, additional, Meler, Pilar, additional, Boned-Riera, Sandra, additional, Cánovas, David, additional, Estela, Jordi, additional, Font, Juli, additional, Purroy, Francisco, additional, Benabdelhak, Ikram, additional, Sanahuja, Jordi, additional, Roquer, Jaume, additional, Rodríguez, Ana, additional, Ois, Ángel, additional, Cuadrado, Elisa, additional, Jiménez, Jordi, additional, Nogués, Xavier, additional, Kuprinski, Jerzy, additional, German, Antoni, additional, Irigoyen, Daniel, additional, Cara, Juan José, additional, Font, Maria Àngels, additional, Huertas, Sonia, additional, Martínez-Domeño, Alejandro, additional, Arroyo, Juan Antonio, additional, Delgado-Mederos, Raquel, additional, Gómez-Choco, Manuel Jesús, additional, Mengual, Juan José, additional, García, Sonia M., additional, Castellanos, M. del Mar, additional, van Eedenburg, Cecile, additional, Cañas, Imma, additional, Espinosa, Jordi, additional, Montull, Santiago, additional, Quesada, Helena, additional, Ustrell, Xavier, additional, Homedes, Christian, additional, Navalpotro, Irene, additional, Casanova, Jordi, additional, Lago, Aida Pilar, additional, Morata, Carmen, additional, Gorriz, David, additional, Moreno, Iván, additional, Tembl, José, additional, Ponz, Alejandro, additional, Fonseca, M. José, additional, Chamarro, Raquel, additional, Gil, Rosario, additional, Oliver, Vicente, additional, Pampliega, Ana, additional, Artero, Arturo, additional, Puchades, Francesc, additional, Landete, Lamberto, additional, Vilar, Carlos, additional, Jiménez, Carmen, additional, Vives, Bárbara, additional, Moragues, M. Dolores, additional, Díaz, Rosa, additional, Tur, Silvia, additional, Escribano, José Bernardo, additional, Lucas, César, additional, Martínez, Francisco, additional, Pons, José Miguel, additional, Romero, Amparo, additional, García, David, additional, Pérez, José, additional, Villaverde, Ramón, additional, Martínez, Salvadora, additional, Rodríguez, Aida, additional, Tejero, Carlos, additional, Pérez, Cristina, additional, Mostacero, Enrique, additional, Fernández, Covadonga, additional, Luna, Alain, additional, Pérez, Tomás, additional, González, Félix, additional, de Arce, Ana, additional, Martínez, Maite, additional, Díez, Noemí, additional, Gállego, Jaime, additional, Zandio, Beatriz, additional, Herrera, María, additional, Aymerich, Nuria, additional, Muñoz, Roberto, additional, Marta, Javier, additional, Artal, Jorge, additional, Errea, José M., additional, Timiraos, Juan José, additional, Moreno, M. Pilar, additional, Freijo, Mar, additional, García, Juan Manuel, additional, Gil, M. Carmen, additional, Revilla, M. Ángeles, additional, Palacio, Enrique, additional, Vázquez, José Luis, additional, Bestué, María, additional, Latorre, Ana, additional, Calvo, Eva, additional, Ballester, Laura, additional, Serrano, Marta, additional, Juega, Jesús M., additional, López, M. Ángeles, additional, Irimia, Pablo, additional, Imaz, Laura, additional, Fuentes, Blanca, additional, Sanz, Borja Enrique, additional, Beltrán, Luis, additional, Ruiz, Gerardo, additional, Martínez, Patricia, additional, Sánchez, Demetrio, additional, Barroso, Emilio, additional, Molina, Igor, additional, Budiño, Marco Antonio, additional, Masjuan, Jaime, additional, de Felipe, Alicia, additional, Matute, Consuelo, additional, Tejada, Javier, additional, Morán, Alberto, additional, Fernández, Esther, additional, Riveira, M. del Carmen, additional, Carnedo, Joaquín, additional, Manquillo, Antonio, additional, González, Raquel, additional, Fernández, José Carlos, additional, Guillan, Marta, additional, Yebra, Miguel, additional, Trejo, José M., additional, Saiz, Jesús, additional, Martínez-Acitores, Juan Carlos, additional, Bravo, Yolanda, additional, Arenillas, Juan Francisco, additional, Calleja, Ana, additional, Cortijo, Elisa, additional, Reyes, Javier, additional, López, Luis, additional, Muñoz, Pedro Luis, additional, Fidalgo, M. Ángeles, additional, Hernández, Jacinto, additional, Gómez, José Carlos, additional, Morán, José Carlos, additional, Gonzalo, Sonia, additional, Marrero, Jorge, additional, Satué, José Ángel, additional, Belinchón, Juan Carlos, additional, Moniche, Francisco, additional, Calderón, Enrique, additional, Escudero, Irene, additional, de la Torre, Javier, additional, Casado, Ignacio, additional, Antón, Joaquín, additional, Portilla, Juan Carlos, additional, Luengo, Juan, additional, Rosal, Joan, additional, Calzado, Elena, additional, Anglada, Juan Carlos, additional, Girón, Juan, additional, Ramírez, José M., additional, Pijierro, Agustín, additional, Roa, Ana, additional, Romero, Jorge, additional, Aguayo, Mariano, additional, Borrachero, Cristina, additional, Sanz, Gema, additional, Gómez, M. José, additional, Rico, Miguel Ángel, additional, Cayon, Antonio, additional, Carmona, Eduardo, additional, Cerro, Román, additional, López, Rafael, additional, Aguirre, Alfonso, additional, Lozano, Francisco, additional, and Rivera., José M., additional
Published: 2018
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35. Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance.

Author: Lamonja-Vicente, Noemí, Dacosta-Aguayo, Rosalia, López-Olóriz, Jorge, Prades-Senovilla, Laia, Roig-Coll, Francesca, Castells-Sánchez, Alba, Soriano-Raya, Juan José, Clemente, Inmaculada, Miralbell, Júlia, Barrios, Maite, López-Cancio, Elena, Cáceres, Cynthia, Arenillas, Juan Francisco, Millán, Mónica, Torán, Pere, Pera, Guillem, Fores, Rosa, Alzamora, Maria Teresa, Mataró, Maria, and Via, Marc
Subjects: BRAIN-derived neurotrophic factor, COGNITIVE aging, C-reactive protein, APOLIPOPROTEIN E, COGNITION, SEX distribution, APOLIPOPROTEINS, GENOTYPES, LONGITUDINAL method
Abstract: Apolipoprotein E (APOE) has an important role in the multiple trajectories of cognitive aging. However, environmental variables and other genes mediate the impact of APOE on cognition. Our main objective was to analyze the effect of APOE genotype on cognition and its interactions and relationships with sex, age, lipid profile, C-reactive protein, and Brain-derived neurotrophic factor (BDNF) genotype in a sample of 648 healthy participants over 50 years of age with a comprehensive neuropsychological assessment. Our results showed that APOE ε2 carriers performed better in the Verbal Memory (p = .002) and Fluency Domains (p = .001). When we studied the effect of sex, we observed that the beneficial effect of APOE ε2 on the normalized values of these cognitive domains occurred only in females (β = 0.735; 95% confidence interval, 0.396-1.074; p = 3.167·10-5 and β = 0.568; 95% confidence interval, 0.276-0.861; p = 1.853·10-4, respectively). Similarly, the sex-specific effects of APOE ε2 were further observed on lipidic and inflammation biomarkers. In the whole sample, APOE ε2 carriers showed significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein. These differences were found only among females. Furthermore, total cholesterol and low-density lipoprotein cholesterol mediated the protective effect of APOE ε2 on cognition in the whole sample and total cholesterol in females, providing candidate physiological mechanisms for the observed genetic effects. Our results show that the neuroprotective role of APOE ε2 in cognition varies with sex and that the lipidic profile partially mediates this protection. Age-related cognitive and functional decline is a continuous biological process with different cognitive trajectories (1). Complex interactions between heritability, environmental influence, and cognitive functions in aging have been highlighted (2). In particular, genetic differences explain around 15%-25% of the variance in life expectancy (3). Therefore, the identification of susceptibility genes and their biological effects on cognitive aging is required to establish interindividual differences in this process and promote early personalized interventions to delay cognitive decline and minimize the financial burden of aging in the health care system. [ABSTRACT FROM AUTHOR]
Published: 2021
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36. Abstract WMP64: Atrial Dysfunction Markers Predicted AF in Elderly Cryptogenic Stroke Patients

Author: Pagola, Jorge, primary, Juega, Jesus, additional, Bustamante, Alejandro, additional, Peñalba, Anna, additional, Gonzalvez, Borja, additional, Moniche, Francisco, additional, Escudero-Martinez, Irene, additional, de Torres, Reyes, additional, Cabezas, Juan Antonio, additional, Arenillas, Juan Francisco, additional, Usero, Maria, additional, De Lera, Mercedes, additional, Montaner, Joan, additional, and Molina, Carlos, additional
Published: 2018
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37. Reported prestroke physical activity is associated with vascular endothelial growth factor expression and good outcomes after stroke

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Ricciardi, Anna Clara, Sobrino, Tomás, Cortés Martínez, Jordi, Pérez de la Ossa, Natalia, Millán, Mònica, Hernández Pérez, María, Gomis Cortina, Meritxell, Dorado, Laura, Muñoz Narbona, Lucía, Campos, Francisco, Arenillas, Juan Francisco, Dávalos Errando, Antoni, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Ricciardi, Anna Clara, Sobrino, Tomás, Cortés Martínez, Jordi, Pérez de la Ossa, Natalia, Millán, Mònica, Hernández Pérez, María, Gomis Cortina, Meritxell, Dorado, Laura, Muñoz Narbona, Lucía, Campos, Francisco, Arenillas, Juan Francisco, and Dávalos Errando, Antoni
Abstract: Physical activity (PhA) prior to stroke has been associated with good outcomes after the ischemic insult, but there is scarce data on the involved molecular mechanisms. Methods: We studied consecutive acute ischemic stroke patients admitted to a single tertiary stroke center. Pre-stroke PhA was evaluated with the International Physical Activity Questionnaire (METS-minute/week). We studied several circulating angiogenic and neurogenic factors at different time-points: Vascular Endothelial Growth Factor (VEGF), Granulocyte Colony-Stimulating Factor (G-CSF) and Brain-Derived Neurotrophic Factor (BDNF) at admission, day 7, and at 3 months. We considered good functional outcome at 3 months (mRS = 2) as primary endpoint, and final infarct volume as secondary outcome. Results: We studied 83 patients with at least two time-point serum determinations (mean age 69.6 years, median NIHSS 17 at admission). Patients more physically active before stroke had a significantly higher increment of serum Vascular Endothelial Growth Factor (VEGF) at 7th day when compared to less active patients. This increment was an independent predictor of good functional outcome at 3 months and was associated with smaller infarct volume in multivariate analyses adjusted for relevant covariates. We did not find independent associations of G-CSF or BDNF levels neither with level of pre-stroke PhA nor with stroke outcomes. Conclusions: Although there are probably more molecular mechanisms by which physical activity exerts its beneficial effects in stroke outcomes, our observation regarding the potential role of VEGF is plausible and in line with previous experimental studies. Further research in this field is needed., Peer Reviewed, Postprint (author's final draft)
Published: 2017

38. Improvement of fatigue in multiple sclerosis by physical exercise is associated to modulation of systemic interferon response

Author: Mulero, Patricia, Almansa, Raquel, Neri, María José, Bermejo-Martin, Jesús Francisco, Archanco, Miguel, Arenillas, Juan Francisco, and Téllez, Nieves
Published: 2015
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39. Factores asociados al mal control de la anticoagulación con antivitaminaK en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author: Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., Suárez Fernández, C., Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, and Rivera., José M.
Abstract: Identificar los factores asociados con el mal control de la anticoagulación con antagonistas de la vitaminaK (AVK) en pacientes con fibrilación auricular no valvular (FANV) atendidos en consultas de Neurología y Medicina Interna de España.
Published: 2018
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40. Deep versus Periventricular White Matter Lesions and Cognitive Function in a Community Sample of Middle-Aged Participants

Author: Soriano-Raya, Juan José, primary, Miralbell, Júlia, additional, López-Cancio, Elena, additional, Bargalló, Núria, additional, Arenillas, Juan Francisco, additional, Barrios, Maite, additional, Cáceres, Cynthia, additional, Toran, Pere, additional, Alzamora, Maite, additional, Dávalos, Antoni, additional, and Mataró, Maria, additional
Published: 2012
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41. Biological Signatures of Brain Damage Associated with High Serum Ferritin Levels in Patients with Acute Ischemic Stroke and Thrombolytic Treatment

Author: Millán, Mónica, primary, Sobrino, Tomás, additional, Arenillas, Juan Francisco, additional, Rodríguez-Yáñez, Manuel, additional, García, María, additional, Nombela, Florentino, additional, Castellanos, Mar, additional, de la Ossa, Natalia Pérez, additional, Cuadras, Patricia, additional, Serena, Joaquín, additional, Castillo, José, additional, and Dávalos, Antoni, additional
Published: 2008
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42. Publisher Correction : Stroke genetics informs drug discovery and risk prediction across ancestries

Author: Mishra, Aniket, Malik, Rainer, He, Yunye, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Georgakis, Marios K, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Caro, Ilana, Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Krebs, Kristi, Wilson, Peter W F, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Consortium, COMPASS, Consortium, INVENT, Initiative, Dutch Parelsnoer, Biobank, Estonian, Consortium, PRECISE4Q, Consortium, FinnGen, Liaw, Yi-Ching, Network, NINDS Stroke Genetics, Consortium, MEGASTROKE, Consortium, SIREN, Group, China Kadoorie Biobank Collaborative, Program, VA Million Veteran, Consortium, International Stroke Genetics, Japan, Biobank, Consortium, CHARGE, Consortium, GIGASTROKE, Millwood, Iona Y, Vaura, Felix C, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M M, Lin, Kuang, Irvin, Marguerite R, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Winsvold, Bendik Slagsvold, Kõrv, Janika, França, Paulo H C, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas G., Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Srinivasasainagendra, Vinodh, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Anderson, Christopher D, Zwart, John-Anker, Niiranen, Teemu J, Parodi, Livia, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Hachiya, Tsuyoshi, Bae, Hee-Joon, Dichgans, Martin, Debette, Stephanie, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Jürgenson, Tuuli, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Namba, Shinichi, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Posner, Daniel C, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Kamanu, Frederick K, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Koido, Masaru, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Le Grand, Quentin, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Shi, Mingyang, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Børge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Bis, Joshua C, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michèle M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-François, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke J H, Kappelle, L Jaap, Esko, Tõnu, Metspalu, Andres, Mägi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jiménez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L M, Rannikmäe, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent N S, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engström, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibañez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muiño, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul I W, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-François, Delavaran, Hossein, Dörr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Ásgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles D A, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tárraga, Carolina, Völzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Le Grand, Quentin, Ferreira, Leslie E, Nagai, Akiko, Murakami, Yoishinori, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, van Vugt, Marion, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Völker, Uwe, de Jager, Phil L, de Cid, Rafael, Nordestgaard, Børge G, Sargurupremraj, Muralidharan, Verma, Shefali S, de Laat, Karlijn F, van Norden, Anouk G W, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul J A M, Gons, Rob A R, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank G W, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjær, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethüm, Kathrin, Gallego-Fabrega, Cristina, Lledós, Miquel, Llucià-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, José, Freijó, Marimar, Arenillas, Juan Francisco, Obach, Victor, Álvarez-Sabín, José, Molina, Carlos A, Ribó, Marc, Muñoz-Narbona, Lucia, Lopez-Cancio, Elena, Millán, Mònica, Diaz-Navarro, Rosa, Vives-Bauza, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sánchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Martí-Fàbregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet M J, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Onland-Moret, N Charlotte, and Heath, Alicia K
Subjects: Stroke, Multidisciplinary, Genetic markers, ddc:500, Predictive markers, Genome-wide association studies
Published: 2022

43. Sex-Stratified Genome-Wide Association Study in the Spanish Population Identifies a Novel Locus for Lacunar Stroke.

Author: Cárcel-Márquez J, Muiño E, Gallego-Fabrega C, Cullell N, Lledós M, Llucià-Carol L, Martín-Campos JM, Sobrino T, Campos F, Castillo J, Freijo M, Arenillas JF, Obach V, Álvarez-Sabín J, Molina CA, Ribó M, Jiménez-Conde J, Roquer J, Muñoz-Narbona L, Lopez-Cancio E, Millán M, Diaz-Navarro R, Vives-Bauza C, Serrano-Heras G, Segura T, Ibañez L, Heitsch L, Delgado P, Dhar R, Krupinski J, Prats-Sánchez L, Camps-Renom P, Guasch M, Ezcurra G, Blay N, Sumoy L, de Cid R, Montaner J, Cruchaga C, Lee JM, Martí-Fàbregas J, and Férnandez-Cadenas I
Subjects: Humans, Male, Spain epidemiology, Female, Middle Aged, Aged, Case-Control Studies, Ischemic Stroke genetics, Ischemic Stroke epidemiology, Genetic Predisposition to Disease genetics, Polymorphism, Single Nucleotide genetics, Genome-Wide Association Study, Stroke, Lacunar genetics
Abstract: Background: Ischemic stroke (IS) represents a significant health burden globally, necessitating a better understanding of its genetic underpinnings to improve prevention and treatment strategies. Despite advances in IS genetics, studies focusing on the Spanish population and sex-stratified analyses are lacking., Methods: A case-control genome-wide association study was conducted with 9081 individuals (3493 IS cases and 5588 healthy controls). IS subtypes using Trial of ORG 10172 in Acute Stroke Treatment criteria were explored in a sex-stratified approach. Replication efforts involved the MEGASTROKE, GIGASTROKE, and the UK Biobank international cohorts. Post-genome-wide association study analysis included: in silico proteomic analysis, gene-based analysis, quantitative trait loci annotation, transcriptome-wide association analysis, and bioinformatic analysis using chromatin accessibility data., Results: Identified as associated with IS and its subtypes were 4 significant and independent loci. Replication confirmed 5p15.2 as a new locus associated with small-vessel occlusion stroke, with rs59970332-T as the lead variant (beta [SE], 0.13 [0.02]; P =4.34×10 -8 ). Functional analyses revealed CTNND2 given proximity and its implication in pathways involved in vascular integrity and angiogenesis. Integration of Hi-C data identified additional potentially modulated genes, and in silico proteomic analysis suggested a distinctive blood proteome profile associated with the lead variant. Gene-set enrichment analyses highlighted pathways consistent with small-vessel disease pathogenesis. Gene-based associations with known stroke-related genes such as F2 and FGG were also observed, reinforcing the relevance of our findings., Conclusions: We found CTNND2 as a potential key molecule in small-vessel occlusion stroke risk, and predominantly in males. This study sheds light on the genetic architecture of IS in the Spanish population, providing novel insights into sex-specific associations and potential molecular mechanisms. Further research, including replication in larger cohorts, is essential for a comprehensive understanding of these findings and for their translation to clinical practice., Competing Interests: Dr Arenillas reports compensation from Medtronic, Daiichi Sankyo, Boehringer Ingelheim, and Pfizer for consultant services; grants from AstraZeneca, Instituto de Salud Carlos III, European Commission and Gerencia de Salud Castilla y León; compensation from Philips for data and safety monitoring services; travel support from Daiichi Sankyo Company. Dr Ribo reports stock holdings in Methinks, Nora, and Ancaonda Biomed; compensation from Cerenovus, Vesalio, Stryker Corporation, Philips, Rapid Pulse, AptaTargets, and Medtronic MiniMed Inc for consultant services; compensation from Sensome for data and safety monitoring services. Dr Heitsch reports employment by Washington University School of Medicine in St. Louis; reports funding from National Institutes of Health and American Heart Association. Dr Dhar reports grants from National Institute of Neurological Disorders and Stroke. The other authors report no conflicts.
Published: 2024
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44. Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.

Author: Ibanez L, Heitsch L, Carrera C, Farias FHG, Dhar R, Budde J, Bergmann K, Bradley J, Harari O, Phuah CL, Lemmens R, Souza AAVO, Moniche F, Cabezas-Juan A, Arenillas JF, Krupinksi J, Cullell N, Torres-Aguila N, Muiño E, Cárcel-Márquez J, Marti-Fabregas J, Delgado-Mederos R, Marin-Bueno R, Hornick A, Vives-Bauza C, Navarro RD, Tur S, Jimenez C, Obach V, Segura T, Serrano-Heras G, Chung JW, Roquer J, Soriano-Tarraga C, Giralt-Steinhauer E, Mola-Caminal M, Pera J, Lapicka-Bodzioch K, Derbisz J, Davalos A, Lopez-Cancio E, Muñoz L, Tatlisumak T, Molina C, Ribo M, Bustamante A, Sobrino T, Castillo-Sanchez J, Campos F, Rodriguez-Castro E, Arias-Rivas S, Rodríguez-Yáñez M, Herbosa C, Ford AL, Arauz A, Lopes-Cendes I, Lowenkopf T, Barboza MA, Amini H, Stamova B, Ander BP, Sharp FR, Kim GM, Bang OY, Jimenez-Conde J, Slowik A, Stribian D, Tsai EA, Burkly LC, Montaner J, Fernandez-Cadenas I, Lee JM, and Cruchaga C
Abstract: During the first hours after stroke onset neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between NIH stroke scale (NIHSS) within six hours of stroke onset and NIHSS at 24h (ΔNIHSS). A total of 5,876 individuals from seven countries (Spain, Finland, Poland, United States, Costa Rica, Mexico and Korea) were studied using a multi-ancestry meta-analyses. We found that 8.7% of ΔNIHSS variance was explained by common genetic variations, and also that early neurological instability has a different genetic architecture than that of stroke risk. Seven loci (2p25.1, 2q31.2, 2q33.3, 4q34.3, 5q33.2, 6q26 and 7p21.1) were genome-wide significant and explained 2.1% of the variability suggesting that additional variants influence early change in neurological deficits. We used functional genomics and bioinformatic annotation to identify the genes driving the association from each loci. eQTL mapping and SMR indicate that ADAM23 (log Bayes Factor (LBF)=6.34) was driving the association for 2q33.3. Gene based analyses suggested that GRIA1 (LBF=5.26), which is predominantly expressed in brain, is the gene driving the association for the 5q33.2 locus. These analyses also nominated PARK2 (LBF=5.30) and ABCB5 (LBF=5.70) for the 6q26 and 7p21.1 loci. Human brain single nuclei RNA-seq indicates that the gene expression of ADAM23 and GRIA1 is enriched in neurons. ADAM23 , a pre-synaptic protein, and GRIA1 , a protein subunit of the AMPA receptor, are part of a synaptic protein complex that modulates neuronal excitability. These data provides the first evidence in humans that excitotoxicity may contribute to early neurological instability after acute ischemic stroke., Research Into Context: Evidence before this study: No previous genome-wide association studies have investigated the genetic architecture of early outcomes after ischemic stroke. Added Value of this study: This is the first study that investigated genetic influences on early outcomes after ischemic stroke using a genome-wide approach, revealing seven genome-wide significant loci. A unique aspect of this genetic study is the inclusion of all of the major ethnicities by recruiting from participants throughout the world. Most genetic studies to date have been limited to populations of European ancestry. Implications of all available evidence: The findings provide the first evidence that genes implicating excitotoxicity contribute to human acute ischemic stroke, and demonstrates proof of principle that GWAS of acute ischemic stroke patients can reveal mechanisms involved in ischemic brain injury.
Published: 2020
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45. Peripheral Arterial Disease study (PERART): prevalence and predictive values of asymptomatic peripheral arterial occlusive disease related to cardiovascular morbidity and mortality.

Author: Alzamora MT, Baena-Díez JM, Sorribes M, Forés R, Toran P, Vicheto M, Pera G, Reina MD, Albaladejo C, Llussà J, Bundó M, Sancho A, Heras A, Rubiés J, and Arenillas JF
Subjects: Aged, Arterial Occlusive Diseases complications, Arterial Occlusive Diseases diagnosis, Biomarkers, Cohort Studies, Coronary Disease etiology, Coronary Disease mortality, Cross-Over Studies, Female, Humans, Incidence, Male, Middle Aged, Peripheral Vascular Diseases complications, Peripheral Vascular Diseases diagnosis, Prevalence, Prospective Studies, Registries, Risk Assessment, Risk Factors, Spain epidemiology, Arterial Occlusive Diseases epidemiology, Coronary Disease epidemiology, Peripheral Vascular Diseases epidemiology
Abstract: Background: The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index (AAI) is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease). The aim of the PERART study (PERipheral ARTerial disease) is to determine the prevalence of peripheral arterial disease (both silent and symptomatic) in a general population of both sexes and determine its predictive value related to morbimortality (cohort study)., Methods/design: This cross-over, cohort study consists of 2 phases: firstly a descriptive, transversal cross-over study to determine the prevalence of peripheral arterial disease, and secondly, a cohort study to evaluate the predictive value of AAI in relation to cardiovascular morbimortality. From September 2006 to June 2007, a total of 3,010 patients over the age of 50 years will be randomly selected from a population adscribed to 24 healthcare centres in the province of Barcelona (Spain). The diagnostic criteria of peripheral arterial disease will be considered as an AAI < 0.90, determined by portable Doppler (8 Mhz probe) measured twice by trained personnel. Cardiovascular risk will be calculated with the Framingham-Wilson tables, with Framingham calibrated by the REGICOR and SCORE groups. The subjects included will be evaluted every 6 months by telephone interview and the clnical history and death registries will be reviewed. The appearance of the following cardiovascular events will be considered as variables of response: transitory ischaemic accident, ictus, angina, myocardial infartction, symptomatic abdominal aneurysm and vascular mortality., Discussion: In this study we hope to determine the prevalence of peripheral arterial disease, especially the silent forms, in the general population and establish its relationship with cardiovascular morbimortality. A low AAI may be a better marker of arterial disease than the classical cardiovascular risk factors and may, therefore, contribute to improving the predictive value of the equations of cardiovascular risk and thereby allowing optimisation of multifactorial treatment of atherosclerotic disease.
Published: 2007
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46. [Usefulness of urgent combined carotid/transcranial ultrasound testing in early prognosis of TIA patients].

Author: Purroy F, Montaner J, Delgado P, Arenillas JF, Molina CA, Santamarina E, Quintana M, and Alvarez-Sabín J
Subjects: Cerebellum pathology, Cerebral Hemorrhage epidemiology, Cerebral Hemorrhage pathology, Electrocardiography, Follow-Up Studies, Humans, Hypertension epidemiology, Ischemic Attack, Transient epidemiology, Myocardial Infarction epidemiology, Peripheral Vascular Diseases epidemiology, Prognosis, Prospective Studies, Brain blood supply, Carotid Arteries diagnostic imaging, Early Diagnosis, Emergency Medical Services, Ischemic Attack, Transient diagnostic imaging, Ultrasonography, Doppler, Transcranial methods
Abstract: Background and Objective: Although patients with ischemic attacks (TIA) experience cardiovascular events frequently within the first 90 days after symptoms onset, strong clinical predictors of early recurrence are lacking. We investigate the value of combined carotid/transcranial ultrasound testing (UST) on the prognosis of TIA patients., Patients and Method: UST was performed < 24 h after symptoms onset among 311 consecutive TIA patients. Stroke recurrence, myocardial infarction, or any vascular event was recorded at 7 and 90 days of follow-up., Results: A total of 20 patients suffered an stroke within 7 days of symptoms onset. During the next 90 days after index TIA, 58 (18.6%) patients experienced an endpoint: 51 cerebral ischemic events, one peripheral arterial disease, 5 myocardial infarctions and one cerebellum hemorrhage. Cox proportional hazards multivariate analyses identified the presence of intracranial stenoses (HR = 3.05; 95% CI, 1.21-7.70; p = 0.018) and carotid territory implication (HR = 15.91; 95% CI, 2.11-120.04; p = 0.007) as independent predictors of stroke within the first 7 days after index TIA. Moreover, at 90 days of follow-up, large-artery occlusive disease was an independent predictor of stroke (HR = 3.07; 95% CI, 1.76-5.38; p < 0.001)., Conclusions: TIA patients with moderate to severe intracranial or extracranial stenoses have a higher risk of stroke recurrence. The routine use of UST within the first 24 h after index TIA can be useful for identifying those patients at high risk in order to plan aggressive prevention therapies.
Published: 2006
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