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Ahmed Salman,1 Mohamed Aon,1 Amr Hussein,2 Mohamed Salman,3 Mohamed Tourky,4 Ahmed Mahmoud,5 Feras Aljarad,6 Mohamed Elkaseer,7 Hossam El-Din Shaaban,8 Ahmed Moustafa,9 Ahmed El-Mikkawy,10 Nahla Gaballa,11 Heba Abdallah,12 Zaky Ftouh Zaky Rashed,13,14 Hesham Elkassar1 1Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Department of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UK; 5Senior Clinical Fellow, Great Western Hospital NHS Foundation Trust, Swindon, UK; 6Lewisham and Greenwich NHS Trust, Lewisham, London, UK; 7General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 8Hepatology and Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 9Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt; 10Hepatology and Gastroenterology Department, Theodor Bilharz Research Institute, Cairo, Egypt; 11Anesthesiology and Intensive Care Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt; 12Clinical Pathology Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt; 13Anesthesiology and Intensive Care Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 14Department of Anesthesia, College of Applied Sciences, Almaarefa university, Ad Diriyah, Riyadh, Saudi ArabiaCorrespondence: Ahmed SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, EgyptTel +20 1000468664Email awea844@gmail.comBackground: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT).Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS).Results: Euthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p< 0.001) or the donor (p< 0.001), hypothyroidism (p=0.008), HBV (p=0.029), larger tumor size (p=0.023), and defective Milan criteria (p=0.022). On multivariate analysis, the age of the patients and donors was the independent factor affecting OS. On univariate analysis, DFS was negatively affected by older age of the patients (p < 0.001) or the donor (p=0.005), hypothyroidism (p=0.005), HBV (p=0.019), larger tumor size (p=0.023), and defective Milan criteria (p=0.020). On multivariate analysis, the age of the patients, thyroid status, and Milan criteria were the independent factors affecting DFS.Conclusion: Hypothyroidism is a risk factor for worse outcomes in HCC patients after liver transplantation.Keywords: hypothyroidism, hepatocellular carcinoma, liver transplantation

The executive secretary occupation in Brazil is often target to incorrect conceptions on which its duties and roles inside the organizational environment, as well as subjected to a few judgments caused by the stereotype of the occupation and of its feminization built along the years through its growth and highlight in the work force. If we can notice the way this occupation came to be seen, we can then understand the need of a research that can verify what is the real perception of the job, and thus, this research came to be, through the viewpoint of the occupational ghetto, characterized, among other aspects, as a mostly female occupation and with low variation on activities performed. Therefore, the main objective of this research was to analyze the Executive Secretary in private institutions and compare them to the Ghetto Thesis based on the research conducted by Truss (1992). The methodology of this study was qualitative and descriptive, as data collected showed their perception about themselves that were asked through an interview. It was verified, through the semi-structured interviews made with four Executive Secretary professionals that there are still characteristics that bring the executive secretary closer to the occupational ghettos and it was also verified others factors that prevent the total characterization of the profession as a ghetto [ABSTRACT FROM AUTHOR]