107 results on '"Anyfantakis D"'
Search Results
2. Rectus sheath hematoma in a single secondary care institution: a retrospective study
- Author
-
Anyfantakis, D., Kastanakis, M., Petrakis, G., and Bobolakis, E.
- Published
- 2015
- Full Text
- View/download PDF
3. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: A WSES observational study
- Author
-
Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Sartelli M., Abu-Zidan F. M., Labricciosa F. M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A. W., Tolonen M., Trana C., Regimbeau J. -M., Hardcastle T., Koshy R. M., Abbas A., Aday U., Adesunkanmi A. R. K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A. B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A. C., Chiarugi M., Cillara N., Cuesta R. C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G. P., Gachabayov M., Gerard G., Ghnnam W., Maurel T. G., Gkiokas G., Gomes C. A., Guner A., Gupta S., Hecker A., Hirano E. S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J. I., Kong V., Korkolis D., Kruger V. F., Kshirsagar A., Simoes R. L., Lanaia A., Lasithiotakis K., Leao P., Arellano M. L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G. M., Major P., Manatakis D., Reitz M. M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F. G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G. -E., Occhionorelli S., Olaoye I., Ordonez C. A., Ozkan Z., Pal A., Palini G. M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G. A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R. A., Tochie J. N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M. Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A. I., Yalkin O., Yilmaz T. U., Unal A. E., Yuan K. -C., Zachariah S. K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G. L., Catena F., Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Sartelli M., Abu-Zidan F. M., Labricciosa F. M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A. W., Tolonen M., Trana C., Regimbeau J. -M., Hardcastle T., Koshy R. M., Abbas A., Aday U., Adesunkanmi A. R. K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A. B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A. C., Chiarugi M., Cillara N., Cuesta R. C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G. P., Gachabayov M., Gerard G., Ghnnam W., Maurel T. G., Gkiokas G., Gomes C. A., Guner A., Gupta S., Hecker A., Hirano E. S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J. I., Kong V., Korkolis D., Kruger V. F., Kshirsagar A., Simoes R. L., Lanaia A., Lasithiotakis K., Leao P., Arellano M. L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G. M., Major P., Manatakis D., Reitz M. M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F. G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G. -E., Occhionorelli S., Olaoye I., Ordonez C. A., Ozkan Z., Pal A., Palini G. M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G. A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R. A., Tochie J. N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M. Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A. I., Yalkin O., Yilmaz T. U., Unal A. E., Yuan K. -C., Zachariah S. K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G. L., and Catena F.
- Abstract
Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8. Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
- Published
- 2019
4. Relationship between obesity index and cardiovascular risk in primary care patients on Crete, Greece: a data driven sub-analysis.
- Author
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Bechraki, L., Anastasaki, M., Papadakis, S., Linardakis, M., Anyfantakis, D., Lionis, C., and Symvoulakis, E. K.
- Subjects
PRIMARY care ,OBESITY ,CARDIOVASCULAR diseases risk factors ,PUBLIC health - Abstract
Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
5. Abdominoscrotal hydrocele in a 9-month old infant
- Author
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Blevrakis, E., Anyfantakis, D. I., and Sakellaris, G.
- Published
- 2011
- Full Text
- View/download PDF
6. Association Between Behavioral Risk Factors And Presence Of Cardiovascular Disease In Primary Healthcare Patients In Crete, Greece.
- Author
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Anastasaki, M., primary, Linardakis, M., additional, Katsiki, N., additional, Papadakis, S., additional, Anastasaki, E. Vasilaki, additional, Duijker, G., additional, Anyfantakis, D., additional, Symvoulakis, E., additional, and Lionis, C., additional
- Published
- 2019
- Full Text
- View/download PDF
7. Primary omental torsion in a 9 year old girl: a case report
- Author
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Anyfantakis, D, Kastanakis, M, Karona, V, Symvoulakis, EK, Fragiadakis, G, Katsougris, N, and Bobolakis, E
- Subjects
Case Presentation ,acute abdomen ,Torsion Abnormality ,Treatment Outcome ,diagnosis ,Romania ,Humans ,Female ,Child ,primary omental torsion ,Omentum ,management - Abstract
Primary torsion of the omentus is an extremely unusual cause of acute abdomen in the pediatric population. This condition occurs from twist of the pedicle of the omental apron around its longer axis, leading to edema, ischaemia and necrosis. Here we present a rare case of a 9 year old girl referred by her general practitioner due to severe right lower quadrant abdominal pain with a presumed diagnosis of acute appendiceal inflammation. Surgical operation disclosed primary omental torsion. The infarcted segment was resected and the girl’s clinical recovery was uneventful without any complication. The condition may mimic a variety of other causes of acute abdominal symptoms. In this case report, a presumed diagnosis of acute appendicitis urgently induced the decision of a surgical approach. Physicians involved in the acute pediatric care have to include this rare condition in the differential diagnosis of acute onset right-sided abdominal pain.
- Published
- 2014
8. Hepatitis E immunosuppressed patients and assisted pregnancy: Is it time to discuss neglected issues?
- Author
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Anyfantakis, D, Symvoulakis, EK, and Kastanakis, S
- Subjects
Letter to the Editor - Published
- 2017
9. Managing venous thromboembolic events in daily practise: ‘‘time is never enough’’
- Author
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Anyfantakis, D., primary, Symvoulakis, E.K., additional, and Mitrouska, I., additional
- Published
- 2016
- Full Text
- View/download PDF
10. Impact of varicocele on biological markers of gonadal function
- Author
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Blevrakis, E., primary, Chatzidarellis, E., additional, Anyfantakis, D., additional, Sakellaris, G., additional, Raissaki, M., additional, Zoras, O., additional, Mamoulakis, C., additional, Sofras, F., additional, and Chrysos, E., additional
- Published
- 2015
- Full Text
- View/download PDF
11. Rectus sheath hematoma in a single secondary care institution: a retrospective study
- Author
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Anyfantakis, D., primary, Kastanakis, M., additional, Petrakis, G., additional, and Bobolakis, E., additional
- Published
- 2013
- Full Text
- View/download PDF
12. Abdominoscrotal hydrocele in a 9-month old infant
- Author
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Blevrakis, E., primary, Anyfantakis, D. I., additional, and Sakellaris, G., additional
- Published
- 2010
- Full Text
- View/download PDF
13. Acute non-traumatic pancreatitis in a patient with pancreas divisum: a case report.
- Author
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Anyfantakis, D., Partalis, N., Polimili, G., and Kastanakis, S.
- Subjects
- *
FETAL development , *CAUCASIAN race , *MAGNETIC resonance imaging , *ENDOSCOPIC retrograde cholangiopancreatography , *DISEASES , *PANCREAS divisum - Abstract
Pancreas divisum is a frequent congenital anatomical anomaly characterized by the failure of fusion of the ducts of Santorini and Wirsung dunng fetal development. Although the condition usually remains asymptomatic, it has been reported to be a predisposing factor of chronic and recurrent idiopathic pancreatitis. We report a case of acute non-traumatic pancreatitis in a 54- year-old Caucasian male with pancreas divisum. Diagnosis was established based on the findings from magnetic resonance imaging and magnetic resonance cholangiopancreatography. The patient was managed conservatively and was discharged home having an uneventful clinical course after five days of hospitalization. Although the role of the pancreas in the induction of acute pancreatitis is still a matter of debate, physicians have to be aware about this prevalent pancreatic anatomic abnormality. Timely detection may help in the prevention of potential recurrent pancreatic reaction. [ABSTRACT FROM AUTHOR]
- Published
- 2013
14. Schmidt's syndrome presenting as a generalised anxiety disorder: a case report.
- Author
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Anyfantakis, D., Symvoulakis, E.K., Vourliotaki, I., and Kastanakis, S.
- Subjects
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ADDISON'S disease , *AUTOIMMUNE thyroiditis , *DIABETES , *ANXIETY , *ENDOCRINE system , *DISEASES - Abstract
Schmidt's syndrome or autoimmune polyglandurar syndrome type 2 represents an uncommon endocrine disorder composed by Addison's disease with autoimmune thyroid disease and/or type 1 diabetes mellitus. The syndrome usually affects women in the fourth decade of their lives. Prompt diagnosis and treatment can prevent serious complications. We present the case of a 64-year-old woman with generalised anxiety, facing socio-economic problems. Her symptoms attributed to stress led to a late diagnosis. Physicians involved have to be aware about endocrine disorders of which first manifestations may have atypical components mimicking mental health problems. [ABSTRACT FROM AUTHOR]
- Published
- 2013
15. Perforation of Meckel's diverticulum by a wood splinter in a 4-year-old child: a case report.
- Author
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Anyfantakis, D., Kastanakis, M., Papadomichelakis, A., Kokinos, I., Katsougris, N., Petrakis, G., Karona, P., and Bobolakis, E.
- Subjects
- *
PTERYGOPALATINE ganglion , *DIVERTICULUM , *ABDOMINAL pain in children , *PEDIATRIC therapy , *SYMPTOMS , *THERAPEUTICS - Abstract
Perforation of Meckels diverticulum by a foreign body represents an unusual and serious clinical occurrence. We present a case of a 4-year-old male who was admitted with symptoms of abdominal pain in the right iliac fossa, raising the suspicion of acute appendicitis, Exploratory laparotomy disclosed normal appendix and perforation of Meckels diverticulum caused by a wood splinter. Meckel's diverticulectomy was performed and the child had an uneventful postoperative course. Preoperative diagnosis of perforated Meckel's diverticulum remains a challenging issue. Diagnosis should be considered in the presence of a right lower quadrant abdominal pain or a positive history of ingestion of a sharp foreign body. [ABSTRACT FROM AUTHOR]
- Published
- 2013
16. Ruling in the diagnosis of methanol intoxication in a young heavy drinker: a case report.
- Author
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Anyfantakis, D., Symvoulakis, E. K., Cristodoulakis, E. V., and Frantzeskakis, G.
- Subjects
- *
ALCOHOL & young adults , *METHANOL , *VISION disorders , *GAS chromatography , *PRIMARY health care - Abstract
Methanol poisoning is a relatively rare but potentially serious medical emergency. Toxicity results when methanol is successively oxidized to the active metabolites formaldehyde and formic acid. We report a case of a 23-year-old male, a high daily alcohol consumer, who attended the local primary health care centre complaining of sudden visual loss. A presumed diagnosis of methanol intoxication was suggested based on the patient's visual impairment and the history of alcohol ingestion. Specific therapy was initiated before a definitive diagnosis. Gas chromatographic determination of methanol levels confirmed the initial diagnostic suspicion. In this case, prompt recognition of methanol intoxication and treatment conditioned a favorable clinical outcome. Given that timely diagnosis and antidote administration are crucial issues in terms of prognosis, we unde~ine the necessity for physicians to be alert for entities provoked by rare environmental factors. [ABSTRACT FROM AUTHOR]
- Published
- 2012
17. Rupture of a splenic artery aneurysm in a previously healthy 53-year-old male.
- Author
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Papadomichelakis, A., Anyfantakis, D., Kastanakis, M., Karona, P., and Bobolakis, E.
- Subjects
- *
SPLENIC artery , *ANEURYSMS , *VASCULAR diseases , *HYPERTENSION , *COMPUTED tomography - Abstract
Splenic artery aneurysms are unusual clinical conditions that may be ruptured resulting into adverse health outcomes. Pregnancy, portal hypertension and atherosclerosis are conditions that predispose to the formation of splenic artery aneurysms. A rare case of a previously healthy man referred to our department by his general practitioner complaining of acute abdominal pain is presented. During the hospital stay, the patient presented hemodynamic instability. Abdominal computed tomography disclosed perihepatic and perisplenic fluid accumulation. A diagnosis of ruptured splenic artery aneurysm was performed and the patient was operated successfully with splenectomy and ligation of the splenic artery. Although the condition is rare, physicians have to be aware of the high mortality rates caused by a ruptured splenic artery aneurysm and include this in the differential diagnosis when they encounter patients with acute abdominal pain and hemodynamic instability. [ABSTRACT FROM AUTHOR]
- Published
- 2014
18. Bio-psychosocial determinants of cardiovascular disease in a rural population on Crete, Greece: formulating a hypothesis and designing the SPILI-III study
- Author
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Shea Sue, Symvoulakis Emmanouil K, Anyfantakis Dimitrios, Lionis Christos, Panagiotakos Demosthenes, and Castanas Elias
- Subjects
Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Background In 1988, the SPILI project was established in order to evaluate the cardiovascular disease (CVD) risk profile of the inhabitants of Spili, in rural Crete, Greece. The first reports from this project revealed that against the unfavourable risk factors' profile observed, only a few men with a previous myocardial infarction were encountered. A follow-up study (SPILI II) was performed twelve years after the initial examination, and the unfavourable cardiovascular risk profile was re-confirmed. Presentation of the Hypothesis This paper presents a hypothesis formulated on the basis of previous research to investigate if dynamic psycho-social determinants, including social coherence of the local community, religiosity and spirituality, are protective against the development of coronary heart disease in a well-defined population. Testing the Hypothesis A follow-up examination of this Cretan cohort is currently being performed to assess the link between psychosocial factors and CVD. Psychosocial factors including sense of control, religiosity and spirituality are assessed in together with conventional CVD risk factors. Smoking and alcohol consumption, as well as dietary habits and activity levels are recorded. Oxidative stress and inflammatory markers, as well as ultrasound measurement of carotid intima media thickness, a preclinical marker of atherosclerosis, will also be measured. Implications of the hypothesis tested The issue of the cardio-protective effect of psycho-social factors would be revisited based on the results of this Cretan cohort; nevertheless, further research is needed across different sub-populations in order to establish a definite relationship. A comprehensive approach based on the aspects of bio-social life may result in more accurate CVD risk management.
- Published
- 2010
- Full Text
- View/download PDF
19. Hepatopulmonary hydatidosis in a ten-year-old girl: a case report
- Author
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Vlachakis Ioannis, Blevrakis Evangellos, Anyfantakis Dimitrios, and Arbiros Ioannis
- Subjects
Medicine - Abstract
Abstract Introduction Hydatid disease is a parasitic infection caused by the tapeworm Echinococcus granulosus and is characterised by cystic lesions in the liver and lungs. Concomitant pulmonary and hepatic localization of hydatid cysts in childhood is unusual and represents a distinct clinical entity called hepatopulmonary hydatidosis. Case presentation A ten-year-old Caucasian girl, a permanent resident of rural Greece, was admitted to hospital reporting a nonspecific symptomatology compatible with a diagnosis of viral infection. Chest radiography revealed a large homogenous circular opacity in the right lung field. On the basis of imaging studies, a diagnosis of hydatidosis was made with synchronous hepatic and pulmonary involvement, successfully managed through a single-stage transthoracic surgical approach. Conclusion This case report highlights the necessity of realizing that hydatid disease continues to be a public health problem, which often remains asymptomatic for years. Therefore, the presence of any homogeneous cystic spherical opacity on routine chest radiography should raise the suspicion of hydatid disease, mainly in endemic areas such as Greece. General practitioners and physicians involved in pediatric care need to be familiar with the diagnosis and management of the variable clinical manifestations of hydatid disease. Taking into consideration that hepatopulmonary hydatidosis represents a special entity that requires a different therapeutic approach may positively affect its economic and social-related burden.
- Published
- 2010
- Full Text
- View/download PDF
20. Selective mutism due to a dog bite trauma in a 4-year-old girl: a case report
- Author
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Anyfantakis Dimitrios, Botzakis Emmanouil, Mplevrakis Evangelos, Symvoulakis Emmanouil K, and Arbiros Ioannis
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Medicine - Abstract
Abstract Introduction A child experiencing an event of threatening or catastrophic nature may experience considerable post-traumatic psychological distress. Dog bites present an important public health problem and are a frequent cause of physical trauma in children. Physicians who manage paediatric trauma may not be vigilant of the high risk of psychological stress in children exposed to a physical injury. Case presentation A 4-year-old white girl of Greek origin, with a dog-bite related trauma was admitted to the University Hospital of Crete, Greece, for surgical repair and intravenous antibiotic therapy due to extensive lesions. Exposure to the traumatic event triggered the onset of an unusual psychological response, selective mutism and acute post-traumatic stress disorder. Conclusion There is limited literature discussing the psychological effect of dog bites in children. Parents and physicians involved in pediatric physical trauma need to be more familiar with post-traumatic behavioral reactions. Awareness of the potential development of such reactions may result in early detection and effective management of children at risk.
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- 2009
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21. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study
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Sartelli, aEmail Author, M., Baiocchi, bEmail Author, G. L., Saverio, Di, cEmail Author, S., Ferrara, dEmail Author, F., Labricciosa, eEmail Author, F. M., Ansaloni, fEmail Author, L., Coccolini, fEmail Author, F., Vijayan, gEmail Author, D., Abbas, hEmail Author, A., Abongwa, iEmail Author, H. K., Agboola, jEmail Author, J., Ahmed, kEmail Author, A., Akhmeteli, lEmail Author, L., Akkapulu, mEmail Author, N., Akkucuk, nEmail Author, S., Altintoprak, oEmail Author, F., Andreiev, gEmail Author, A. L., Anyfantakis, pEmail Author, D., Atanasov, qEmail Author, B., Bala, rEmail Author, M., Balalis, sEmail Author, D., Baraket, tEmail Author, O., Bellanova, uEmail Author, G., Beltran, vEmail Author, M., Melo, wEmail Author, R. B., Bini, xEmail Author, R., Bouliaris, yEmail Author, K., Brunelli, zEmail Author, D., Castillo, Mario, aaEmail Author, A., Catani, abEmail Author, M., Che, Jusoh, acEmail Author, A., Chichom-Mefire, adEmail Author, A., Cocorullo, aeEmail Author, G., Coimbra, afEmail Author, R., Colak, agEmail Author, E., Costa, ahEmail Author, S., Das, aiEmail Author, K., Delibegovic, ajEmail Author, S., Demetrashvili, akEmail Author, Z., Carlo, Di, alEmail Author, I., Kiseleva, amEmail Author, N., Zalabany, El, anEmail Author, T., Faro, aoEmail Author, M., Ferreira, apEmail Author, M., Fraga, aqEmail Author, G. P., Gachabayov, arEmail Author, M., Ghnnam, asEmail Author, W. M., Giménez, Maurel, atEmail Author, T., Gkiokas, auEmail Author, G., Gomes, avEmail Author, C. A., Griffiths, awEmail Author, E., Guner, axEmail Author, A., Gupta, ayEmail Author, S., Hecker, azEmail Author, A., Hirano, aqEmail Author, E. S., Hodonou, baEmail Author, A., Hutan, bbEmail Author, M., Ioannidis, Bc, O., Bdemail, Author, Isik, beEmail Author, A., Ivakhov, bfEmail Author, G., Jain, bgEmail Author, S., Jokubauskas, bhEmail Author, M., Karamarkovic, biEmail Author, A., Kauhanen, bjEmail Author, S., Kaushik, ayEmail Author, R., Kavalakat, bkEmail Author, A., Kenig, blEmail Author, J., Khokha, bmEmail Author, V., Khor, bnEmail Author, D., Kim, aaEmail Author, D., boEmail Author, J. I., Kong, bpEmail Author, V., Lasithiotakis, bqEmail Author, K., Leão, brEmail Author, P., Leon, bsEmail Author, M., Litvin, btEmail Author, A., Lohsiriwat, buEmail Author, V., López-Tomassetti, Fernandez, bvEmail Author, E., Lostoridis, bwEmail Author, E., Maciel, aaEmail Author, J., Major, bxEmail Author, P., Dimova, byEmail Author, A., Manatakis, bzEmail Author, D., Marinis, caEmail Author, A., Martinez-Perez, cbEmail Author, A., Marwah, ccEmail Author, S., Mcfarlane, Cd, M., Ceemail, Author, Mesina, cfEmail Author, C., Pȩdziwiatr, cgEmail Author, M., Michalopoulos, chEmail Author, N., Misiakos, ciEmail Author, E., Mohamedahmed, cjEmail Author, A., Moldovanu, ckEmail Author, R., Montori, fEmail Author, G., Mysore, Narayana, clEmail Author, R., Negoi, cmEmail Author, I., Nikolopoulos, cnEmail Author, I., Novelli, coEmail Author, G., Novikovs, amEmail Author, V., Olaoye, cpEmail Author, I., Omari, cqEmail Author, A., Ordoñez, crEmail Author, C. A., Ouadii, csEmail Author, M., Ozkan, ctEmail Author, Z., Pal, cuEmail Author, A., Palini, coEmail Author, G. M., Partecke, cvEmail Author, L. I., Pata, Francesco, cwEmail Author, F., cxEmail Author, M., Pereira, Júnior, cyEmail Author, G. A., Pintar, czEmail Author, T., Pisarska, daEmail Author, M., Ploneda-Valencia, dbEmail Author, C. F., Pouggouras, bwEmail Author, K., Prabhu, dcEmail Author, V., Ramakrishnapillai, ddEmail Author, P., Regimbeau, deEmail Author, J. -M., Reitz, dfEmail Author, M., Rios-Cruz, dgEmail Author, D., Saar, dhEmail Author, S., Sakakushev, diEmail Author, B., Seretis, djEmail Author, C., Sazhin, bfEmail Author, A., Shelat, dkEmail Author, V., Skrovina, dlEmail Author, M., Smirnov, dmEmail Author, D., Spyropoulos, dnEmail Author, C., Strzałka, doEmail Author, M., Talving, dhEmail Author, P., Teixeira, Gonsaga, dpEmail Author, R. A., Theobald, gEmail Author, G., Tomadze, dqEmail Author, G., Torba, drEmail Author, M., Tranà, aEmail Author, C., Ulrych, dsEmail Author, J., Uzunoğlu, nEmail Author, M. Y., Vasilescu, dtEmail Author, A., Occhionorelli, duEmail Author, S., Venara, dvEmail Author, A., Vereczkei, dwEmail Author, A., Vettoretto, dxEmail Author, N., Vlad, dtEmail Author, N., Walȩdziak, dyEmail Author, M., Yilmaz, dzEmail Author, T. U., Yuan, eaEmail Author, K. -C., Yunfeng, ebEmail Author, C., Zilinskas, bhEmail Author, J., Grelpois, deEmail Author, G., Catena, hEmail Author, F., Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Universidade do Minho, Sartelli M., Abu-Zidan F.M., Labricciosa F.M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A.W., Tolonen M., Trana C., Regimbeau J.-M., Hardcastle T., Koshy R.M., Abbas A., Aday U., Adesunkanmi A.R.K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A.B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A.C., Chiarugi M., Cillara N., Cuesta R.C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G.P., Gachabayov M., Gerard G., Ghnnam W., Maurel T.G., Gkiokas G., Gomes C.A., Guner A., Gupta S., Hecker A., Hirano E.S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J.I., Kong V., Korkolis D., Kruger V.F., Kshirsagar A., Simoes R.L., Lanaia A., Lasithiotakis K., Leao P., Arellano M.L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G.M., Major P., Manatakis D., Reitz M.M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F.G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G.-E., Occhionorelli S., Olaoye I., Ordonez C.A., Ozkan Z., Pal A., Palini G.M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G.A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R.A., Tochie J.N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M.Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A.I., Yalkin O., Yilmaz T.U., Unal A.E., Yuan K.-C., Zachariah S.K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G.L., Catena F., HUS Abdominal Center, II kirurgian klinikka, University of Helsinki, İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, and Altintoprak, Fatih
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Male ,Medicina Básica [Ciências Médicas] ,030230 surgery ,Logistic regression ,0302 clinical medicine ,Injury Severity Score ,Interquartile range ,Risk Factors ,Antibiotics ,Abdomen ,Diagnosis ,Acute peritonitis ,Early warning score ,Emergency surgery ,Source control ,Adult ,Aged ,Chi-Square Distribution ,Female ,Hospital Mortality ,Humans ,Logistic Models ,Middle Aged ,Sepsis ,Prognosis ,Mortality rate ,Acute peritoniti ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,aarly warning score ,acute peritonitis ,emergency surgery ,source control ,abdomen ,adult ,aged ,chi-square distribution ,female ,hospital mortality ,humans ,injury severity score ,logistic models ,male ,middle aged ,risk factors ,sepsis ,prognosis ,3. Good health ,Management ,Ciências Médicas::Medicina Básica ,Emergency Medicine ,Research Article ,Human ,medicine.medical_specialty ,Logistic Model ,Sepsi ,lcsh:Surgery ,NO ,03 medical and health sciences ,Internal medicine ,medicine ,Acute appendicitis ,Science & Technology ,business.industry ,Risk Factor ,Surgery ,lcsh:RD1-811 ,lcsh:RC86-88.9 ,3126 Surgery, anesthesiology, intensive care, radiology ,medicine.disease ,Observational study ,business ,Chi-squared distribution ,Kidney disease - Abstract
Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
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- 2019
22. Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections : a prospective multicentre study (WISS Study)
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Elif Colak, Iyiade Olaoye, Raghuveer Mn, Tugan Tezcaner, David W da Costa, Varut Lohsiriwat, Vinod V. Prabhu, Tadeja Pintar, Fausto Catena, Raul Coimbra, Daniel Rios-Cruz, Zaza Demetrashvili, Dimitrios Anyfantakis, Isidoro Di Carlo, John Agboola, Konstantinos Pouggouras, Charalampos Spyropoulos, AA Munyika, Sanjay Marwah, Stefano Rausei, Giovanni Bellanova, Francesco Pata, András Vereczkei, Piotr Major, Nereo Vettoretto, Ari Leppäniemi, Ramakrishnapillai Padmakumar, Geanina Loredana Curca, Oussama Baraket, Marco Catani, Massimo Sartelli, Miguel Leon, Konstantinos Bouliaris, Maria Luisa Sánchez de Molina, Eftychios Lostoridis, Gianfranco Cocorullo, Bandar Alharthi, Ionut Negoi, Zygimantas Kuliesius, Sanjay Gupta, Maurice Zida, Terry Curry, Savas Bayrak, Frederic Branger, Pedro Leão, Teresa Giménez Maurel, Saleh Abdel Kader, Cristian Mesina, Marcelo A. Beltrán, Eudaldo López-Tomassetti Fernandez, Carlos A. Ordoñez, Martin Hutan, Jakub Kenig, Avidyl Krasniqi, Sumita A Jain, Tonguç Utku Yılmaz, Miran Rems, Dmitry Smirnov, Gabrielle H. van Ramshorst, Robin Kaushik, Renato Bessa Melo, Mario Paulo Faro, Ouadii Mouaqit, Asri Che Jusoh, Adamu Amhed, Abdelkarim H. Omari, Jaan Tepp, Ali Guner, Miklosh Bala, Charampolos Seretis, Alain Chichom-Mefire, Nadezda Drozdova, Matej Skrovina, Saila Kauhanen, Aurélien Venara, Aintzane Lizarazu Pérez, Kuo-Ching Yuan, Adesina Ajibade, Silvia Figueiredo Costa, Yoshimitsu Izawa, Mahir Gachabayov, Michael McFarlane, Ricardo Alessandro Teixeira Gonsaga, Ashok Kshirsagar, Jae Gil Lee, Gustavo Pereira Fraga, Koray Das, Jan Ulrych, Tamer El Zalabany, Luca Ansaloni, Victor Y. Kong, Matti Tolonen, Jorge Pereira, Nick Michalopoulos, Georgios Gkiokas, Arda Isik, Orestis Ioannidis, Aleix Martínez-Pérez, Seckin Akkucuk, Giovanni Sinibaldi, Gabriela Elisa Nita, Jae Il Kim, Yunfeng Cui, Federico Coccolini, Ewen A. Griffiths, Roberto Bini, Salomone Di Saverio, Mushira Enani, Boris Sakakushev, Mustafa Yener Uzunoglu, Asrhaf Abbas, Fikri M. Abu-Zidan, David van Dellen, Sandra Gutierrez, Samir Delibegovic, Ioannis Nikolopoulos, Daniele Brunelli, Vishal G Shelat, Ferdinando Agresta, Gerson Alves Pereira Júnior, Goran Augustin, Mantas Jokubauskas, Zeynep Özkan, Sanoop K. Zachariah, Nutu Vlad, Romeo Lages Simões, Konstantinos Lasithiotakis, Giorgio Vasquez, Matthew Boal, Daniele Marrelli, Sanjay Kumar Yadav, Paola Rodriguez Ossa, Vladimir Khokha, Carlos Augusto Gomes, Justas Zilinskas, Gianluca Guercioni, Renol M. Koshy, Gian Luca Baiocchi, Athanasios Marinis, Aleksandar Karamarkovic, Radu Moldovanu, Andrey V. Borodach, Myftar Torba, II kirurgian klinikka, Clinicum, [et al.], Universidade do Minho, Sartelli, M., Abu Zidan, F., Catena, F., Griffiths, E., Di Saverio, S., Coimbra, R., Ordoñez, C., Leppaniemi, A., Fraga, G., Coccolini, F., Agresta, F., Abbas, A., Abdel Kader, S., Agboola, J., Amhed, A., Ajibade, A., Akkucuk, S., Alharthi, B., Anyfantakis, D., Augustin, G., Baiocchi, G., Bala, M., Baraket, O., Bayrak, S., Bellanova, G., Beltràn, M., Bini, R., Boal, M., Borodach, A., Bouliaris, K., Branger, F., Brunelli, D., Catani, M., Che Jusoh, A., Chichom Mefire, A., Cocorullo, G., Colak, E., Costa, D., Costa, S., Cui, Y., Curca, G., Curry, T., Das, K., Delibegovic, S., Demetrashvili, Z., Di Carlo, I., Drozdova, N., El Zalabany, T., Enani, M., Faro, M., Gachabayov, M., Giménez Maurel, T., Gkiokas, G., Gomes, C., Gonsaga, R., Guercioni, G., Guner, A., Gupta, S., Gutierrez, S., Hutan, M., Ioannidis, O., Isik, A., Izawa, Y., Jain, S., Jokubauskas, M., Karamarkovic, A., Kauhanen, S., Kaushik, R., Kenig, J., Khokha, V., Kim, J., Kong, V., Koshy, R., Krasniqi, A., Kshirsagar, A., Kuliesius, Z., Lasithiotakis, K., Leão, P., Lee, J., Leon, M., Lizarazu Pérez, A., Lohsiriwat, V., López Tomassetti Fernandez, E., Lostoridis, E., Mn, R., Major, P., Marinis, A., Marrelli, D., Martinez Perez, A., Marwah, S., Mcfarlane, M., Melo, R., Mesina, C., Michalopoulos, N., Moldovanu, R., Mouaqit, O., Munyika, A., Negoi, I., Nikolopoulos, I., Nita, G., Olaoye, I., Omari, A., Ossa, P., Ozkan, Z., Padmakumar, R., Pata, F., Pereira Junior, G., Pereira, J., Pintar, T., Pouggouras, K., Prabhu, V., Rausei, S., Rems, M., Rios Cruz, D., Sakakushev, B., Sánchez de Molina, M., Seretis, C., Shelat, V., Simões, R., Sinibaldi, G., Skrovina, M., Smirnov, D., Spyropoulos, C., Tepp, J., Tezcaner, T., Tolonen, M., Torba, M., Ulrych, J., Uzunoglu, M., van Dellen, D., van Ramshorst, G., Vasquez, G., Venara, A., Vereczkei, A., Vettoretto, N., Vlad, N., Yadav, S., Yilmaz, T., Yuan, K., Zachariah, S., Zida, M., Zilinskas, J., and Ansaloni, L.
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medicine.medical_specialty ,Infections ,Intra-abdominal ,Sepsis ,Septic shock ,Ciências da Saúde [Ciências Médicas] ,Surgery ,Emergency Medicine ,Ciências Médicas::Ciências da Saúde ,Sepsi ,medicine.medical_treatment ,macromolecular substances ,030230 surgery ,GUIDELINES ,Likelihood ratios in diagnostic testing ,PERITONITIS ,03 medical and health sciences ,PROGNOSTIC-FACTORS ,0302 clinical medicine ,Internal medicine ,Medicine and Health Sciences ,MANAGEMENT ,medicine ,Intra-abdominal Sepsis ,Univariate analysis ,Science & Technology ,COLONIC PERFORATION ,Receiver operating characteristic ,business.industry ,Abdominal Infection ,Immunosuppression ,3126 Surgery, anesthesiology, intensive care, radiology ,medicine.disease ,3. Good health ,030220 oncology & carcinogenesis ,Infections, Intra-abdominal Sepsis ,Observational study ,Infection ,business ,SYSTEM ,Research Article - Abstract
BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. ----- METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. ----- RESULTS: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p
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- 2015
23. Relationship between obesity index and cardiovascular risk in primary care patients on Crete, Greece: a data driven sub-analysis.
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Bechraki L, Anastasaki M, Papadakis S, Linardakis M, Anyfantakis D, Lionis C, and Symvoulakis EK
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- Adult, Aged, Aged, 80 and over, Body Mass Index, Female, Greece epidemiology, Heart Disease Risk Factors, Humans, Male, Middle Aged, Obesity complications, Obesity epidemiology, Primary Health Care, Risk Factors, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology
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Background: The present sub-analysis aimed to examine the relationship between obesity index and cardiovascular risk among primary care attendees., Study Design: Stratified random sampling was previously used to recruit general practitioners, practicing on Crete island, Greece, whose patients were then enrolled., Methods: Initial sample included 815 primary care attendees (55.7% women; mean age 65.2 years; range 40-98 years). Due to missing values regarding 13 participants, data from 802 patients were included for the current analysis. Body measurements (weight, height), among other bio-clinical parameters, were recorded upon practice visit. The 10-year cardiovascular disease risk was estimated using the European Society of Cardiology (and other societies), 10-year Systematic Coronary Risk Estimation and multivariate linear regression was used to assess relationships between Obesity Index and cardiovascular disease risk., Results: Higher risk is shown to be significantly related with male gender, older age, unemployed/retired status, urban area of living or smoking (p<0.05), as well as with higher levels of obesity index (stand. beta=0.048, p=0.028)., Conclusions: Obesity Index may be useful for cardiovascular disease risk prediction and correction at the primary care settings, since obesity is easily addressed during the first medical contact.
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- 2022
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24. Hemiparesis and facial droop in an older woman.
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Anyfantakis D and Kastanakis S
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- Aged, 80 and over, Diagnosis, Differential, Facial Paralysis etiology, Facial Paralysis pathology, Facial Paralysis therapy, Female, Glucose administration & dosage, Glucose therapeutic use, Humans, Hypoglycemia therapy, Paresis etiology, Paresis pathology, Paresis therapy, Facial Paralysis diagnosis, Hypoglycemia complications, Paresis diagnosis
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Competing Interests: Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: none. Further details of The BMJ policy on financial interests are here: https://www.bmj.com/about-bmj/resources-authors/forms-policies-and-checklists/declaration-competing-interests.
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- 2022
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25. COVID-19 pandemic and reasons to prioritize the needs of the health care system to ensure its sustainability: A scoping review from January to October 2020 (Review).
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Anyfantakis D, Mantadaki AE, Mastronikolis S, Spandidos DA, and Symvoulakis EK
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The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led the World Health Organization to characterize the pandemic as a public health emergency of international concern. National health care systems in countries during the initial surge of the pandemic were unable to handle the sanitarian crisis that had emerged. Thus, the prevention and control of future global health emergencies must be a priority. The present scoping review aimed to retrieve articles that summarize the current experience on issues related to historical knowledge, and epidemiology, clinical features and overall burden of SARS-CoV-2 on health care services. In summary, a comprehensive overview of the information that has been learnt during this period is presented in the current review. Furthermore, taking into account the global experience, the need for planning cohesive and functional health services before similar pandemic events occur in the future is highlighted. The next public health issue should be prevented rather than treated. In spite of the vaccination benefits, a number of sporadic cases of SARS-CoV-2infections will persist. Information collected remains relevant for appraising how similar threats can be faced in the future. Overall, collaborative health care plans need to be rethought to increase preparedness., Competing Interests: DAS is the Editor-in-Chief for the journal, but had no personal involvement in the reviewing process, or any influence in terms of adjudicating on the final decision, for this article. The other authors declare that they have no competing interests., (Copyright: © Anyfantakis et al.)
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- 2021
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26. Holly Sacrament: the medicine of spiritual immortality or a vehicle for contamination?
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Anyfantakis D
- Subjects
- Humans, COVID-19 transmission, Religion
- Abstract
The Holy Communion is the oldest Christian practice, through which a gathered group of people partake bread and wine with a shared spoon. The pandemic of COVID-19 produced unexpected social instability and chaos. In Greece, a recent bishop's death from COVID-19 re-awaked the issue of infection transmission by using a common chalice and spoon. This review evaluates the available medical literature on this topic from the beginning of the pandemic until today., (Copyright© by the Medical Assotiation of Zenica-Doboj Canton.)
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- 2021
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27. Hypothyroidism Induced Rhabdomyolysis in a Young Male after a Single Intramuscular Injection: A Case Report.
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Anyfantakis D and Kastanakis S
- Abstract
Hypothyroidism is a common endocrine disorder resulting from the inability of the thyroid gland to produce sufficient thyroid hormone for the metabolic demands of the body. Clinical symptoms and signs are often non-specific and subtle. Muscular symptoms are frequently reported. Rhabdomyolysis is a life-threatening condition caused by necrosis of muscles and leakage of toxic intracellular components into the blood circulation. Hypothyroidism induced rhabdomyolysis, represents an unusual clinical occurrence. This is a case of a middle-aged man, who presented with severe myalgias, following an intramuscular injection. After laboratory work-up, he was diagnosed with rhabdomyolysis. Laboratory and ultrasound tests disclosed primary hypothyroidism of auto-immune etiology.
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- 2021
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28. Primary care and the COVID-19 pandemic: Schrödinger's cat.
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Symvoulakis EK and Anyfantakis D
- Abstract
The #COVID19 pandemic crisis requires the collaboration of all healthcare providers. Every contribution is welcome to gain time during the phase of "system state" superposition. https://bit.ly/3m4SBxY., Competing Interests: Conflict of interest: E.K. Symvoulakis has nothing to disclose. Conflict of interest: D. Anyfantakis has nothing to disclose., (Copyright ©ERS 2021.)
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- 2021
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29. A Young Male With Anorexia, Abdominal Complaints and Marked Blood Eosinophilia.
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Anyfantakis D
- Abstract
Peripheral blood eosinophilia represents a frequent finding in routine clinical practice when absolute eosinophil count is found to be greater than 0.5 x 109/L (500/µL). Common causes include parasitic infections, allergic reactions, and hyper-eosinophilic syndrome. Eosinophilia secondary to malignancy represents an uncommon presentation. Here we report an atypical case of a 47-year-old previously healthy male who presented to a primary care setting complaining of fatigue and anorexia for the last two weeks. The evaluation revealed leucocytosis and peripheral hypereosinophilia with an absolute eosinophil count of 14.13×109/L (37%). Following an extensive diagnostic work in a secondary care centre he was finally diagnosed with rectal carcinoma. This case highlights that solid malignancy should be considered in patients with marked peripheral eosinophilia., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Anyfantakis et al.)
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- 2020
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30. Burden of metabolic syndrome among primary care patients in Crete, Greece: A descriptive study.
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Anastasaki M, Papadakis S, Linardakis M, Anyfantakis D, Symvoulakis EK, and Lionis C
- Subjects
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Greece, Humans, Male, Medical Audit, Metabolic Syndrome etiology, Middle Aged, Risk Factors, Cost of Illness, Metabolic Syndrome physiopathology, Primary Health Care
- Abstract
Background: Metabolic Syndrome (MetS) is a clustering of abdominal obesity, hypertriglyceridaemia, low HDL cholesterol, hyperglycaemia and hypertension. Early identification of MetS is important for preventing cardiovascular disease (CVD). MetS has not been systematically explored in Greek primary care., Objectives: To examine MetS frequency among primary care patients 40 years of age or older in Crete., Methods: A descriptive study was conducted (July-December 2015). General practitioners, randomly selected from regional physician listings, recruited consecutive patients, 40 years of age or older, visiting their practice. Chart audits were completed for eligible patients using medical records, including demographics and cardiovascular risk factors (hypertension, dyslipidaemia, diabetes mellitus). MetS was defined using the revised NCEP ATP III criteria. Frequencies with 95% confidence intervals were calculated. Gender differences were explored using Chi-square and Mann-Whitney tests., Results: Our sample consisted of 815 patients (55.7% female; mean age 65.2 years; range 40-98 years) from 44 GP practices. Overall, 73.6% (95% CI 70.4, 76.6) were identified with MetS, with a higher proportion of males (75.6%; 95% CI 71.0, 79.8) than females (72.0%; 95% CI 67.8, 76.0). Among the total sample, relatively high rates of hypertension (males: 64.5%; 95% CI 59.9, 70.0 and females: 61.1%; 95% CI 56.8, 65.8), dyslipidaemia (males: 69.3%; 95% CI 64.3, 74.1 and females: 63.5%; 95% CI 59.3, 68.0), diabetes mellitus (males: 46.9%; 95% CI 42.2, 52.4 and females: 36.5%; 95% CI 32.5, 41.6) and coronary heart disease (males: 21.2%; 95% CI 17.0, 25.2 and females: 6.2%; 95% CI 4.2, 8.6) were documented., Conclusion: MetS and CVD risk factors were encountered at high frequencies in the studied population of primary care patients in Crete.
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- 2020
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31. Religiosity, Well-Being and 'Slowing Down' Ageing Damage: A Literature Review.
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Anyfantakis D, Symvoulakis EK, and Lionis CD
- Abstract
Telomere length (TL) represents an important marker of cellular aging. Its shortening affects human health and longevity by inducing senescence, apoptosis, and oncogenesis. Advanced ageing and negative behavioral and lifestyle factors decrease TL. The relationship between positive psycho-social factors and longer telomeres has given rise to a growing number of research efforts. Among these, religiosity poses a particular interest since it is associated with a wide range of favorable health outcomes. In this direction, recent literature reports, suggest a positive link between religiosity and TL. Underlying mechanisms for this association are not yet clarified. In this review, we would like to summarize the current knowledge on the link between religiosity and TL. Taking this opportunity, we recall findings from a cohort study in rural Crete, Greece that adds evidence on the discussion of potential psycho-social mediators which some may prevent shortening of TL., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Anyfantakis et al.)
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- 2020
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32. Spontaneous Intra-Cerebral Haemorrhage Presenting with Chest Pain in a Healthy Young Man.
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Anyfantakis D, Katsanikaki F, and Kastanakis S
- Abstract
Spontaneous, non-traumatic intra-cerebral haemorrhage is the second most common type of stroke and is associated with significant morbidity and mortality. It is defined as the presence of blood within the cerebral parenchyma without prior injury or surgery. The purpose of this work is to describe an atypical presentation of spontaneous intra-cerebral haemorrhage in a healthy young adult. A literature review was also carried out., Learning Points: Spontaneous intra-cerebral haemorrhage is a challenge in daily practice due to the wide range of clinical symptoms on presentation.Chest pain mimicking acute myocardial infarction is an atypical presentation of intra-cerebral haemorrhage.In the primary care setting, misdiagnosis of a patient with spontaneous cerebral haemorrhage with chest discomfort suggesting cardiac aetiology and prompting antiplatelet/aspirin therapy could result in disaster.Taking a detailed history and conducting a thorough neurological examination is important in every clinical encounter and may trigger diagnostic suspicion., Competing Interests: Conflicts of Interests: The Authors declare that there are no competing interests., (© EFIM 2020.)
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- 2020
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33. Diabetic neuropathy and restless legs syndrome: can a known chronic condition slow down our diagnostic way of thinking? A case report and a short literature overview.
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Anyfantakis D, Katsanikaki F, and Symvoulakis EK
- Abstract
Restless legs syndrome is a common lifelong neurological disorder with a negative impact on the patients' sleep and quality of life. Despite its common occurrence in the general population, the condition usually remains undiagnosed. Patients with diabetes run at a higher risk to suffer from restless legs syndrome. Diabetic neuropathy, in particular, shares similar clinical characteristics with restless legs syndrome and reduces significantly the patients' quality of life. Our aim was to report on an interesting case of restless legs syndrome in a patient with diabetes seeking medical advice for a ten-year long insomnia. Sleep deprivation was falsely attributed to diabetic neuropathy. A literature overview of the up-to-date knowledge was performed in order to summarize available information and provide primary care physicians with a comprehensive way of clinical thinking to differentiate peripheral neuropathy and restless legs syndrome manifestations.
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- 2020
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34. Holy Communion and Infection Transmission: A Literature Review.
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Anyfantakis D
- Abstract
The Holy Communion originated in the Last Supper of Jesus Christ, nearly 2,000 years ago. According to the Bible, the night before his crucifixion, Jesus Christ shared with his 12 apostles a meal of bread and wine. During the meal, Christ instructed his disciplines to eat and drink in his memory, saying that bread is his body and wine is his blood. Today, faithful people worldwide share the consecrated bread and wine retracted from a chalice with a Holy Communion spoon. The novel coronavirus that emerged in December 2019 recorded a rapid exponential spread across space and time. The ongoing pandemic of coronavirus disease has affected people from all cultures and religions. In Greece, the pandemic concurred with the Easter celebration. Measures of social distancing have been implemented. Among others, churches have closed their doors to the public in order to avoid religious mass gatherings. The issue of the novel coronavirus transmission by partaking Holy Communion has received much criticism. In this review, we aimed to retrieve articles that summarize the current knowledge on the selected topic. In order to offer a balanced analysis of the subject, we have also assessed the theological framework of the Holy mystery., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Anyfantakis et al.)
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- 2020
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35. An Elderly Woman with Pyrexia of Unknown Origin.
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Anyfantakis D, Katsanikaki F, and Kastanakis S
- Abstract
Pyrexia of unknown origin represents a diagnostic challenge in the daily practice. Clinical features are often subtle or inadequate to recognize the etiology of prolonged fever. Endocrine etiology of pyrexia of unknown origin is not common. Here we present a case of an elderly female seeking medical advice from her general practitioner due to a four-week history of moderate fever, malaise and loss of appetite. Initial outpatient diagnostic workup was negative. During repeated examination a slight enlargement of thyroid gland was noticed. Thyroid function tests revealed a very low level of thyroid stimulated hormone along with elevated free T4 suggesting subacute thyroiditis. Low dose administration of corticosteroids led to clinical improvement and fever remission. Physicians involved must be aware about this unusual presentation of thyroiditis and include the condition in the differential diagnosis of prolonged unexplained fever. In the absence of clinical signs and symptoms, an abnormal thyroid function test may prevent from unnecessary investigations and inefficient hospital admission.
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- 2020
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36. Rectal Lipoma in an Elderly Male: A Case Report.
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Anyfantakis D, Karona P, and Kastanakis M
- Abstract
Lipomas of the gastrointestinal tract are uncommon, benign non-epithelial tumors detected incidentally during surgery or endoscopy. Rectal lipomas are extremely rare. Patients may be asymptomatic or present with rectal bleeding, constipation, tenesmus and signs of intestinal obstruction. Preoperative diagnosis is challenging. Management consists of simple observation, endoscopic or laparoscopic removal, and open surgery. We present a case of an elderly male admitted to the Department of Surgery of a general hospital in Crete, complaining of a protruding rectal mass during defecation. CT raised the diagnostic suspicion. The mass was removed by trans-anal excision. Histopathology of the resected specimen confirmed the diagnosis. The patient had an uneventful postoperative course and was discharged home at the second postoperative day., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Anyfantakis et al.)
- Published
- 2020
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37. Insisting Pain on the Mid-scapular Line.
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Anyfantakis D and Symvoulakis EK
- Abstract
Neoplastic diseases are commonly paired with a wide range of non-specific clinical symptoms. Even the most alarming complaints pose a low positive predictive value making diagnosis of an underlying malignancy a major detective challenge for the primary care physician. Therefore, although cancer may be suspected for not be missed, as management failure within primary care, diagnosis usually occurs in the context of a secondary care setting. Here we present a case of a patient seeking medical advice from his general practitioner due to a two-week history of back thoracic pain. Following investigations, the patient was early diagnosed with myeloma. Current notion of target-driven laboratory tests utility that may be used as possible clues for the detection of multiple myeloma at a primary care level is also discussed to enhance capacity., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2019, Anyfantakis et al.)
- Published
- 2019
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38. R on T Phenomenon and Long QTc Syndrome due to Moxifloxacin in a Healthy Female.
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Anyfantakis D and Makrakis G
- Subjects
- Anti-Bacterial Agents administration & dosage, Community-Acquired Infections drug therapy, Electrocardiography, Female, Humans, Long QT Syndrome diagnosis, Middle Aged, Moxifloxacin administration & dosage, Pneumonia, Bacterial drug therapy, Anti-Bacterial Agents adverse effects, Long QT Syndrome chemically induced, Moxifloxacin adverse effects
- Abstract
Long QT syndrome is characterized by prolongation of the corrected QT interval and is associated with fatal arrhythmias. R on T phenomenon is the coincidence of a premature ventricular complex with a T wave and may result to syncope and sudden cardiac death. Here we present a case of a 59-year-old woman with no previous history of medication, receiving moxifloxacin for community-acquired pneumonia. She was admitted complaining for thoracic pain and shortness of breath. Electrocardiogram showed both R on T phenomenon and QT prolongation. After discontinuation of the antibiotic symptoms and electrocardiography features were resolved. Physicians should always be vigilant about this rare and potentially fatal adverse drug reaction especially in high risk patients. General practitioners in particular being the first point of access in care have to carefully assess and detect high risk patients before the administration of moxifloxacin.
- Published
- 2019
39. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study.
- Author
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Sartelli M, Abu-Zidan FM, Labricciosa FM, Kluger Y, Coccolini F, Ansaloni L, Leppäniemi A, Kirkpatrick AW, Tolonen M, Tranà C, Regimbeau JM, Hardcastle T, Koshy RM, Abbas A, Aday U, Adesunkanmi ARK, Ajibade A, Akhmeteli L, Akın E, Akkapulu N, Alotaibi A, Altintoprak F, Anyfantakis D, Atanasov B, Augustin G, Azevedo C, Bala M, Balalis D, Baraket O, Baral S, Barkai O, Beltran M, Bini R, Bouliaris K, Caballero AB, Calu V, Catani M, Ceresoli M, Charalampakis V, Jusoh AC, Chiarugi M, Cillara N, Cuesta RC, Cobuccio L, Cocorullo G, Colak E, Conti L, Cui Y, De Simone B, Delibegovic S, Demetrashvili Z, Demetriades D, Dimova A, Dogjani A, Enani M, Farina F, Ferrara F, Foghetti D, Fontana T, Fraga GP, Gachabayov M, Gérard G, Ghnnam W, Maurel TG, Gkiokas G, Gomes CA, Guner A, Gupta S, Hecker A, Hirano ES, Hodonou A, Hutan M, Ilaschuk I, Ioannidis O, Isik A, Ivakhov G, Jain S, Jokubauskas M, Karamarkovic A, Kaushik R, Kenig J, Khokha V, Khokha D, Kim JI, Kong V, Korkolis D, Kruger VF, Kshirsagar A, Simões RL, Lanaia A, Lasithiotakis K, Leão P, Arellano ML, Listle H, Litvin A, Lizarazu Pérez A, Lopez-Tomassetti Fernandez E, Lostoridis E, Luppi D, Machain V GM, Major P, Manatakis D, Reitz MM, Marinis A, Marrelli D, Martínez-Pérez A, Marwah S, McFarlane M, Mesic M, Mesina C, Michalopoulos N, Misiakos E, Moreira FG, Mouaqit O, Muhtaroglu A, Naidoo N, Negoi I, Nikitina Z, Nikolopoulos I, Nita GE, Occhionorelli S, Olaoye I, Ordoñez CA, Ozkan Z, Pal A, Palini GM, Papageorgiou K, Papagoras D, Pata F, Pędziwiatr M, Pereira J, Pereira Junior GA, Perrone G, Pintar T, Pisarska M, Plehutsa O, Podda M, Poillucci G, Quiodettis M, Rahim T, Rios-Cruz D, Rodrigues G, Rozov D, Sakakushev B, Sall I, Sazhin A, Semião M, Sharda T, Shelat V, Sinibaldi G, Skicko D, Skrovina M, Stamatiou D, Stella M, Strzałka M, Sydorchuk R, Teixeira Gonsaga RA, Tochie JN, Tomadze G, Ugoletti L, Ulrych J, Ümarik T, Uzunoglu MY, Vasilescu A, Vaz O, Vereczkei A, Vlad N, Walędziak M, Yahya AI, Yalkin O, Yilmaz TU, Ünal AE, Yuan KC, Zachariah SK, Žilinskas J, Zizzo M, Pattonieri V, Baiocchi GL, and Catena F
- Subjects
- Abdomen abnormalities, Adult, Aged, Chi-Square Distribution, Female, Hospital Mortality, Humans, Injury Severity Score, Logistic Models, Male, Middle Aged, Risk Factors, Sepsis physiopathology, Abdomen physiopathology, Prognosis, Sepsis diagnosis
- Abstract
Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted., Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018., Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO
2 ) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8., Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality., Competing Interests: Competing interestsThe authors declare that they have no competing interests.- Published
- 2019
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40. Multiorgan paradoxical embolism in an elderly female with a patent foramen ovale: a case report.
- Author
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Anyfantakis D, Karona P, Kastanaki P, Kourakos A, and Kastanakis M
- Abstract
Paradoxical embolism is an uncommon cause of arterial occlusion with a high mortality burden. Current evidence suggests that patent foramen ovale is the most important etiological factor of paradoxical embolism, by acting as a pathway for a thromboembolic material originating from the peripheral veins, passing through the lungs and entering the systemic circulation. Here we present a case of paradoxical embolism in the mesenteric and renal arteries associated with pulmonary embolism and deep vein thrombosis in an elderly woman with no predisposing risk factor. A diagnosis of paradoxical embolism was considered and the presence of a patent foramen ovale was consequently confirmed with a transesophageal echocardiography. Urgent thrombolysis saved the life of the patient. Paradoxical embolism represents an emergency and therefore prompt diagnosis and initiation of therapy may prevent adverse outcomes.
- Published
- 2019
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41. Organ Donation Awareness: Rethinking Media Campaigns.
- Author
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Symvoulakis EK, Markaki A, Anyfantakis D, and Rachiotis G
- Subjects
- Advertising, Europe, Humans, Public Opinion, Attitude to Health, Awareness, Marketing organization & administration, Tissue Donors psychology, Tissue and Organ Procurement organization & administration
- Published
- 2018
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42. A fatal case of cytomegalovirus disease in an immunocompetent young woman: a case report.
- Author
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Anyfantakis D, Damianaki A, Krietsepi V, Panou E, and Kastanakis S
- Subjects
- Adult, Fatal Outcome, Female, Humans, Immunocompetence, Cytomegalovirus Infections diagnosis, Cytomegalovirus Infections drug therapy
- Abstract
Cytomegalovirus can cause severe disease with adverse outcome in immunocompromised patients. Severe cytomegalovirus infection in previously healthy individuals is rare. Here we present an unusual case of cytomegalovirus infection with neurological and pulmonary involvement in a previously healthy young woman with no history of immuno-suppression. Unfortunately, the disease followed a malignant course and despite the efforts of the medical staff the patient died. CMV infection should be considered in the diagnostic work-up of immunocompetent patients with fever and unexplained neurological or pulmonary manifestations. Although uncertainty exists regarding the optimal treatment of CMV in healthy individuals, early recognition and administration of ganciclovir may prevent a fatal outcome.
- Published
- 2018
43. Prospective Observational Study on acute Appendicitis Worldwide (POSAW).
- Author
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Sartelli M, Baiocchi GL, Di Saverio S, Ferrara F, Labricciosa FM, Ansaloni L, Coccolini F, Vijayan D, Abbas A, Abongwa HK, Agboola J, Ahmed A, Akhmeteli L, Akkapulu N, Akkucuk S, Altintoprak F, Andreiev AL, Anyfantakis D, Atanasov B, Bala M, Balalis D, Baraket O, Bellanova G, Beltran M, Melo RB, Bini R, Bouliaris K, Brunelli D, Castillo A, Catani M, Che Jusoh A, Chichom-Mefire A, Cocorullo G, Coimbra R, Colak E, Costa S, Das K, Delibegovic S, Demetrashvili Z, Di Carlo I, Kiseleva N, El Zalabany T, Faro M, Ferreira M, Fraga GP, Gachabayov M, Ghnnam WM, Giménez Maurel T, Gkiokas G, Gomes CA, Griffiths E, Guner A, Gupta S, Hecker A, Hirano ES, Hodonou A, Hutan M, Ioannidis O, Isik A, Ivakhov G, Jain S, Jokubauskas M, Karamarkovic A, Kauhanen S, Kaushik R, Kavalakat A, Kenig J, Khokha V, Khor D, Kim D, Kim JI, Kong V, Lasithiotakis K, Leão P, Leon M, Litvin A, Lohsiriwat V, López-Tomassetti Fernandez E, Lostoridis E, Maciel J, Major P, Dimova A, Manatakis D, Marinis A, Martinez-Perez A, Marwah S, McFarlane M, Mesina C, Pędziwiatr M, Michalopoulos N, Misiakos E, Mohamedahmed A, Moldovanu R, Montori G, Mysore Narayana R, Negoi I, Nikolopoulos I, Novelli G, Novikovs V, Olaoye I, Omari A, Ordoñez CA, Ouadii M, Ozkan Z, Pal A, Palini GM, Partecke LI, Pata F, Pędziwiatr M, Pereira Júnior GA, Pintar T, Pisarska M, Ploneda-Valencia CF, Pouggouras K, Prabhu V, Ramakrishnapillai P, Regimbeau JM, Reitz M, Rios-Cruz D, Saar S, Sakakushev B, Seretis C, Sazhin A, Shelat V, Skrovina M, Smirnov D, Spyropoulos C, Strzałka M, Talving P, Teixeira Gonsaga RA, Theobald G, Tomadze G, Torba M, Tranà C, Ulrych J, Uzunoğlu MY, Vasilescu A, Occhionorelli S, Venara A, Vereczkei A, Vettoretto N, Vlad N, Walędziak M, Yilmaz TU, Yuan KC, Yunfeng C, Zilinskas J, Grelpois G, and Catena F
- Subjects
- Acute Disease therapy, Adult, Appendectomy adverse effects, Appendectomy methods, Chi-Square Distribution, Female, Hospitalization statistics & numerical data, Humans, Laparoscopy methods, Laparoscopy statistics & numerical data, Length of Stay statistics & numerical data, Logistic Models, Male, Prospective Studies, Tomography, X-Ray Computed methods, Treatment Outcome, Appendectomy standards, Appendicitis surgery
- Abstract
Background: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments., Methods: This prospective multicenter observational study was performed in 116 worldwide surgical departments from 44 countries over a 6-month period (April 1, 2016-September 30, 2016). All consecutive patients admitted to surgical departments with a clinical diagnosis of AA were included in the study., Results: A total of 4282 patients were enrolled in the POSAW study, 1928 (45%) women and 2354 (55%) men, with a median age of 29 years. Nine hundred and seven (21.2%) patients underwent an abdominal CT scan, 1856 (43.3%) patients an US, and 285 (6.7%) patients both CT scan and US. A total of 4097 (95.7%) patients underwent surgery; 1809 (42.2%) underwent open appendectomy and 2215 (51.7%) had laparoscopic appendectomy. One hundred eighty-five (4.3%) patients were managed conservatively. Major complications occurred in 199 patients (4.6%). The overall mortality rate was 0.28%., Conclusions: The results of the present study confirm the clinical value of imaging techniques and prognostic scores. Appendectomy remains the most effective treatment of acute appendicitis. Mortality rate is low., Competing Interests: The data was completely anonymized, and no patient or hospital information was collected in the database. The study protocol was approved by the board of the WSES, and the study was conducted under its supervision. The board of the WSES grants the proper ethical conduct of the study.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
- Published
- 2018
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44. Colorectal cancer, screening and primary care: A mini literature review.
- Author
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Hadjipetrou A, Anyfantakis D, Galanakis CG, Kastanakis M, and Kastanakis S
- Subjects
- Colonoscopy instrumentation, Colonoscopy methods, Colorectal Neoplasms epidemiology, Colorectal Neoplasms prevention & control, Colorectal Neoplasms therapy, Humans, Incidence, Occult Blood, Primary Health Care organization & administration, Primary Prevention methods, Risk Factors, Secondary Prevention methods, Tomography, X-Ray Computed, Colorectal Neoplasms diagnosis, Early Detection of Cancer methods, Mass Screening methods, Physicians, Primary Care organization & administration, Primary Health Care methods
- Abstract
Colorectal cancer (CRC) is a common health problem, representing the third most commonly diagnosed cancer worldwide and causing a significant burden in terms of morbidity and mortality, with annual deaths estimated at 700000. The western way of life, that is being rapidly adopted in many regions of the world, is a well discussed risk factor for CRC and could be targeted in terms of primary prevention. Furthermore, the relatively slow development of this cancer permits drastic reduction of incidence and mortality through secondary prevention. These facts underlie primary care physicians (PCPs) being assigned a key role in health strategies that enhance prevention and prompt diagnosis. Herein, we review the main topics of CRC in the current literature, in order to better understand its pathogenesis, risk and protective factors, as well as screening techniques. Furthermore, we discuss preventive and screening policies to combat CRC and the crucial role served by PCPs in their successful implementation. Relevant articles were identified through electronic searches of MEDLINE and through manual searches of reference lists., Competing Interests: Conflict-of-interest statement: All authors have declared that no competing interests exist.
- Published
- 2017
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45. Drug resistant pulmonary tuberculosis mimicking a flu-like syndrome in an elderly man: an atypical case report.
- Author
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Hadjipetrou A, Anyfantakis D, Damianaki A, Krietsepi V, and Kastanakis S
- Subjects
- Aged, Antitubercular Agents pharmacology, Antitubercular Agents therapeutic use, Biopsy, Fine-Needle, Bronchoalveolar Lavage Fluid microbiology, Diagnostic Errors, Drug Resistance, Multiple, Bacterial, Drug Substitution, Drug Therapy, Combination, Humans, Male, Mycobacterium tuberculosis isolation & purification, Optic Neuritis etiology, Pneumonia diagnosis, Tomography, X-Ray Computed, Tuberculosis, Multidrug-Resistant microbiology, Tuberculosis, Pulmonary diagnostic imaging, Tuberculosis, Pulmonary microbiology, Mycobacterium tuberculosis drug effects, Tuberculosis, Multidrug-Resistant diagnosis, Tuberculosis, Pulmonary diagnosis
- Abstract
Despite remarkable reductions in its incidence and mortality, tuberculosis (TB) continues to be a major health burden globally. Pulmonary TB occasionally challenges physicians, either due to TB's ability to mimic many different conditions or because of the increasing number of drug-resistant Mycobacterium tuberculosis isolates. Here we present a case of pulmonary TB with both characteristics and a brief review of the relevant literature.
- Published
- 2017
46. Subcutaneous Facial and Neck Emphysema as First Sign of Intestinal Perforation in a Female Patient After a Routine Colonoscopy.
- Author
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Anyfantakis D, Kastanakis M, Karona P, Papadomichelakis A, and Bobolakis E
- Abstract
Colonoscopy is a safe procedure for the diagnosis and management of colorectal diseases. Colonic perforation due to colonoscopy represents an uncommon complication. Here we present an unusual case of iatrogenic bowel perforation resulting in subcutaneous facial and neck emphysema, pneumomediastinum and pneumoretroperitoneum. Taking a detailed recent medical history information is always required when encountering patients with subcutaneous emphysema after invasive examination procedures. Alertness on iatrogenic complication eventualities may improve prognosis and avoid life-threatening conditions., Competing Interests: No conflict of interest was declared by the authors.
- Published
- 2016
- Full Text
- View/download PDF
47. Pilomotor seizures: an unusual presentation of limbic encephalitis.
- Author
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Symvoulakis EK, Anyfantakis D, and Zaganas I
- Subjects
- Humans, Magnetic Resonance Imaging, Male, Middle Aged, Limbic Encephalitis complications, Piloerection, Seizures etiology
- Published
- 2016
- Full Text
- View/download PDF
48. Blood donation knowledge and attitudes among undergraduate health science students: A cross-sectional study.
- Author
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Papagiannis D, Rachiotis G, Symvoulakis EK, Anyfantakis D, Douvlataniotis K, Zilidis C, Markaki A, and Hadjichristodoulou C
- Subjects
- Adolescent, Adult, Cross-Sectional Studies, Female, Greece, Humans, Male, Pilot Projects, Attitude to Health, Blood Donors, Education, Medical, Undergraduate, Patient Education as Topic, Students, Surveys and Questionnaires
- Abstract
Awareness towards blood donation can be empowered by health professionals' role-modelling. We aimed to assess knowledge and attitudes among Greek undergraduate medical laboratory students. A questionnaire was distributed to 330 students (response rate: 88.7%). Overall, 24% had donated blood at least once, with males 4.62 times more likely to be donors. Voluntary, non-remunerated blood donors were more likely to be repeaters. A quarter of all students were inclined to offer blood for monetary reward, with men more prone to accept payment. There is a need to campaign health science students during formal education through need-based as well as altruistic 'smart' messages., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
49. Primary bacterial peritonitis in a previously healthy adolescent female: A case report.
- Author
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Blevrakis E, Anyfantakis D, Blevrakis E, and Vlachakis I
- Abstract
Introduction: Acute pneumococcal peritonitis represents an unusual entity characterized by infection in the abdominal cavity despite the absence of an obvious causative source. Patients with portal hypertension such as cirrhotics and those with nefrotic syndrome are more frequently encountered in the every day practice., Presentation of Case: A 14 years old female was referred to our department by his general practitioner with a 24h history of right lower abdominal pain and fever. Clinical examination was suggestive for peritonitis and the girl was transferred to the operation room. A diagnosis of primary pneumococcal peritonitis was made on the basis of the findings during surgery and the microbiological tests. Institution of appropriate antibiotics resulted to complete recovery., Discussion: A mini literature review was performed., Conclusion: Primary bacterial peritonitis in adolescents is extremely rare. Surgeons are required to be aware of this entity., (Copyright © 2016. Published by Elsevier Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
50. Syndrome of Reduced Sensitivity to Thyroid Hormones: Two Case Reports and a Literature Review.
- Author
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Anyfantakis A, Anyfantakis D, and Vourliotaki I
- Abstract
Resistance to thyroid hormone (RTH) is an extremely rare dominantly inherited condition of impaired tissue responsiveness to thyroid hormone (TH). Most patients with RTH have mutations in the gene that encodes the β isoform of the receptor of thyroid hormone ( THR-β gene). Mutant receptors are unable to activate or repress target genes. The majority of them are asymptomatic or rarely have hypo- or hyperthyroidism. RTH is suspected by the finding of persistent elevation of serum levels of free T3 (FT3) and free T4 (FT4) and nonsuppressed TSH. We present two cases of RTH diagnosed after total thyroidectomy. The first patient was initially diagnosed with primary hyperthyroidism due to toxic multinodular goiter. The second patient had undergone thyroidectomy for multinodular goiter 16 years before diagnosis of RTH. After thyroidectomy, although on relatively high doses of levothyroxine, both of them presented with the laboratory findings of RTH. Genetic analysis revealed RTH.
- Published
- 2016
- Full Text
- View/download PDF
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