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A patent application has been filed for a topical formulation that can be used to treat pain conditions such as joint pain. The formulation includes benzocaine and capsaicin and can be applied as a cream or gel. The patent application also includes specific claims regarding the composition and method of administering the formulation. This research aims to provide novel and more effective treatments for pain relief. [Extracted from the article]

A patent application titled "Composition And Methods Of Treatment Using Transdermal Hormone Supplementation" has been published online. The application discusses the use of transdermal hormone supplementation for various therapeutic purposes, such as growth hormone deficiency and chronic kidney disease. The invention involves a composition for transdermal hormone supplementation, which includes an aqueous gel containing a hormone supplement, b-caryophyllene, eucalyptol, menthol, salicylic glycosides, and 2,5-Dimethoxy-p-cymene. The method of treatment involves applying the gel to the skin. The invention aims to provide an inexpensive and accessible method of transdermal hormone supplementation without the need for medical professionals. [Extracted from the article]

A patent application titled "Methods Of Treating Neuropathic Pain" has been published online. The application describes a method of treating neuropathic pain, specifically fibromyalgia-induced neuropathic pain, by administering patches containing a formulation of menthol, camphor, and methyl salicylate to the top and bottom of the foot. The inventor claims that this method provides a more specific and potent treatment option for individuals suffering from fibromyalgia, who currently have limited treatment options available. The patent application provides detailed information on the formulation and dosage of the patches. [Extracted from the article]

A patent has been issued for methods of using low-dose doxepin to improve sleep. Insomnia is a prevalent health problem in the United States, affecting millions of people. Doxepin, a tricyclic antidepressant, has been found to be effective in treating premature termination of sleep and fragmented sleep patterns without causing undesirable side effects. The patent describes methods for administering doxepin to patients with specific sleep deficiencies, such as early awakenings or fragmented sleep in the final hour of an 8-hour sleep period. The dosage of doxepin ranges from 1 mg to 6 mg, and the oral formulation can be in the form of tablets or capsules. This patent provides potential solutions for individuals struggling with sleep disorders. [Extracted from the article]

A patent application has been filed for a composition and method of treatment using transdermal hormone supplementation. The invention aims to provide a homeopathic hormone-based gel for topical treatment of humans with additional therapeutically-beneficial compounds. The composition includes a hormone supplement, cannabidiol (CBD), eucalyptol, menthol, salicylic glycosides, and 2,5-Dimethoxy-p-cymene. The method involves applying an aqueous gel to the skin, containing the hormone supplement, CBD, eucalyptol, menthol, salicylic glycosides, and 2,5-Dimethoxy-p-cymene. The invention seeks to provide an inexpensive and accessible means of transdermal hormone supplementation without the need for medical professionals. [Extracted from the article]

A new study conducted by researchers at Mashhad University of Medical Sciences in Iran explores the feasibility of using sustained-release pellets of chlorpheniramine maleate (CPM) for therapy. The study investigates the effects of different factors on the properties of the pellets, such as curing temperature and time, particle size distribution, mechanical strength, and drug release rate. The results show that the optimal formulation consists of 8% CPM, 67% Compritol(R), and 25% Avicel, dried at 40°C for 4 hours, and releases about 90% of the drug within 12 hours. This research provides valuable insights into the development of lipid-based sustained-release matrix pellets for chlorpheniramine therapy. [Extracted from the article]

The article focuses on research from the University of Bristol that examines how topical treatment use is captured and reported in childhood eczema studies. Topics include challenges in data collection, the impact of accurate reporting on trial outcomes, and recommendations for improving data quality in eczema research.

Researchers at Universitatsklinikum Bonn in Germany have found that clemastine, an antihistamine, has neuroprotective effects in a rat model of neonatal hypoxic-ischemic brain injury. The study showed that clemastine reduced white matter loss and increased the number of oligodendrocytes, which are important for myelination. The researchers identified the MAPK/ERK pathway as a potential mechanism underlying the neuroprotective effects of clemastine. These findings suggest that clemastine could be a potential treatment for hypoxic-ischemic encephalopathy, a common cause of long-term disability in neonates. [Extracted from the article]

A new study from Duke University School of Medicine explores the mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8. The research found that TRPM8 channels desensitize to cold and chemically induced coolness, and that TRPM8 inhibitors can be used for pain relief in cold-evoked pain disorders and migraines. The study used cryo-electron microscopy, electrophysiology, and molecular dynamics simulations to reveal the structural determinants crucial for TRPM8 desensitization. This research provides insights into therapeutic development for altering cold sensation. [Extracted from the article]

A study conducted by researchers at Georgetown University examined the potential impact of a ban on flavored cigars. The study found that half of adult cigar users reported flavored cigars as their usual brand. The researchers developed a decision-theoretic framework to assess the impact of a ban on flavored cigars alone, as well as the impact of a ban on flavored cigars combined with a ban on menthol cigarettes and non-tobacco flavored electronic nicotine delivery systems (ENDS). The study concluded that a ban on flavored cigars alone may be partially undermined by the substitution of menthol cigarettes, and adding a ban on menthol cigarettes could offset this substitution and improve public health. However, the simultaneous implementation of a ban on flavored cigars, menthol cigarettes, and ENDS may reduce the public health impact of the bans. Further research is needed to understand the impact of ENDS on cigar use and the effectiveness of enforcement and non-flavor-related policies. [Extracted from the article]

A new study conducted at the Hind Institute of Medical Sciences in Uttar Pradesh, India, explores the complexities of polysubstance dependence. The study focuses on a 24-year-old male who was dependent on alcohol, pregabalin, cyproheptadine, and dexamethasone. The case highlights the challenges in diagnosing and managing overlapping substance use disorders and emphasizes the importance of thorough assessment and comprehensive intervention strategies. The patient's treatment involved pharmacotherapy and motivational enhancement therapy, resulting in significant improvement and abstinence from all substances. The study provides valuable insights into the dynamics of polysubstance misuse and offers a comprehensive treatment approach for such cases. [Extracted from the article]

A recent study conducted by researchers at Poznan University of Medical Sciences in Poland explored the use of ketoprofen-loaded microemulsion-based gels with the addition of menthol for topical application. The study aimed to analyze the physicochemical properties of the gels and investigate the correlation between the gel composition, mechanical properties, and drug release process. The results indicated that the presence of ketoprofen slightly decreased yield stress values, while menthol had a stronger effect on hardness and adhesiveness. The study concluded that cohesiveness and drug release rate were independent of the gel composition. Further information on this research can be found in the journal article "Microemulsion-Based Polymer Gels with Ketoprofen and Menthol: Physicochemical Properties and Drug Release Studies." [Extracted from the article]

A clinical trial, NCT06485479, is being conducted to determine the effectiveness of different quit smoking ads for individuals who smoke menthol cigarettes. The trial will involve approximately 1,400 US adults (ages 21+) who smoke menthol cigarettes and will use an online randomized trial format. Participants will be shown various ads related to quitting smoking and will provide feedback on their perceived effectiveness. The trial aims to assess the efficacy of different ad themes in promoting smoking cessation. The trial is a collaboration between the University of North Carolina, Chapel Hill, the Food and Drug Administration (FDA), and the National Institute on Drug Abuse (NIDA), and the data will be shared with external investigators through the UNC Dataverse digital data repository. [Extracted from the article]

Teething can be a painful experience for infants and children, but it is important to be cautious when trying to soothe their pain. The U.S. Food and Drug Administration (FDA) warns against using products containing benzocaine or lidocaine, as well as homeopathic tablets and other products, as they can be dangerous and even lead to serious injury or death. The American Academy of Pediatrics (AAP) recommends alternative methods such as rubbing the gums with a clean finger or providing a firm rubber teething ring. It is important to avoid using teething jewelry, as it can cause strangulation and choking. If there are any concerns or questions about medication, it is advised to contact the FDA's Division of Drug Information. [Extracted from the article]

This document provides information about a clinical trial, NCT06474728, that is being conducted by the Children's Hospital of Fudan University. The trial aims to investigate the effectiveness of emollients containing postbiotic Saccharomyces and Lactobacillus in reducing the risk of atopic dermatitis (AD) recurrence in pediatric patients aged 0-6 years during the remission phase. The trial involves 98 children with moderate AD who are randomly assigned to either an experimental group or a control group. The experimental group continues to use the emollient twice daily, while the control group discontinues both medication and emollient. The recurrence of AD and other measures of skin health are assessed throughout the intervention phase. The study is not yet recruiting participants and aims to enroll 98 individuals between the ages of 1 month and 6 years who meet the diagnostic criteria for moderate atopic dermatitis and have not received certain topical medications within a specified timeframe. Informed consent is required for participation in the study. [Extracted from the article]

New research from Arizona State University has uncovered new insights into the human protein TRPM8, which regulates cold sensations. By understanding the evolutionary history of TRPM8, scientists hope to develop pain medications that do not affect body temperature and do not carry the risks of addiction. The study used ancestral sequence reconstruction to determine what TRPM8 proteins from long-extinct animals might have looked like, allowing researchers to understand how TRPM8 has changed over hundreds of millions of years. This research could lead to the development of non-addictive pain therapies that target specific types of pain without triggering temperature regulation side effects. [Extracted from the article]

This article discusses a clinical trial, NCT06476405, that is investigating the levels of harmful and potentially harmful constituents (HPHCs) in the air after the use of Ploom heated tobacco products and combustible cigarettes by adult smokers. The trial will measure various air quality parameters and is expected to be completed by September 30, 2024. The study aims to compare the effects of different tobacco products on air and aerosol analytical endpoints. The study is not yet recruiting participants and is sponsored by Altria Client Services LLC. [Extracted from the article]

Researchers from Arizona State University have conducted a study on the TRPM8 channel, which is responsible for cold sensing and pain perception. The study aimed to understand the molecular foundations of TRPM8 activation modes in order to develop mode-specific therapies. Through ancestral sequence reconstruction, the researchers discovered that the cold and menthol sensitivity of the TRPM8 channel evolved separately over time. These findings provide valuable insights into sensory receptor biology and may lead to innovative therapeutic interventions. [Extracted from the article]

A recent report from researchers at Mahidol University in Thailand discusses the potential use of menthol, a compound found in peppermint, for the treatment of leukemia. The study found that menthol inhibits the proliferation of leukemic cells and increases the production of extracellular vesicles. These vesicles were found to induce apoptosis, or programmed cell death, in leukemic cells. The researchers identified two proteins, ATG3 and caspase-3, that play a role in this process. This research suggests that menthol may have anti-leukemic effects through the regulation of apoptosis. [Extracted from the article]

A report from Universitas Brawijaya in Indonesia discusses the use of chlorpheniramine maleate (CTM) for self-medication. The study found that misuse of CTM can lead to various health issues, including heart rate irregularity and central nervous system disorders. The research aimed to analyze the correlation between sociodemographic factors and the appropriateness of CTM use for self-medication. The results showed that education level was the only factor that had a weak correlation with the appropriate use of CTM. The study highlights the importance of proper knowledge and education when it comes to self-medication. [Extracted from the article]

A study conducted at Tehran University of Medical Sciences in Iran has found that the drug Niclosamide shows promise as a potential antipruritic agent. Pruritus, or itching, is a common symptom caused by various factors, including serotonin. The study used mouse models to examine the effects of Niclosamide on serotonin receptors and found that it successfully suppressed pruritus and reduced the expression of certain receptors. These findings suggest that Niclosamide could be an effective treatment for pruritus. [Extracted from the article]

A recent study conducted by researchers at the University of Zaragoza in Spain focused on the solubility of lidocaine in eutectic mixtures of camphor, thymol, and dl-menthol. The study found that lidocaine was significantly more soluble in these mixtures compared to water. The researchers also analyzed the thermophysical properties of the mixtures and found that the interaction between camphor and thymol was stronger than with dl-menthol. The study concluded that lidocaine showed the strongest interactions with thymol molecules. This research provides insights into potential solutions for improving the solubility of drugs in aqueous media, which is a challenge for the pharmaceutical industry. [Extracted from the article]

A recent study conducted by researchers at Virginia Commonwealth University has found that the use of menthol in tobacco products may increase the likelihood of developing nicotine dependence. The study suggests that menthol alters sensitivity to nicotine by modulating nicotinic acetylcholine receptors (nAChRs). Specifically, the study found that the alpha 5 nicotinic subunit plays a role in regulating menthol intake in mice. However, the study also found that the alpha 5 subunit does not modulate the antinociceptive properties of menthol. Further research is needed to fully understand the effects of menthol on nAChRs. [Extracted from the article]

A recent study conducted by researchers at the Russian Academy of Medical Sciences examined the efficacy of Blue Cap emollient in treating patients with psoriasis. The study included 10 patients with psoriasis vulgaris, and they were divided into two groups. The first group received basic therapy along with the emollient, while the second group received only basic therapy. The results showed that the inclusion of the emollient led to a significant decrease in the severity of psoriasis and an improvement in the patients' skin condition compared to the group that did not receive the emollient. This research provides valuable insights into the potential benefits of emollient therapy for psoriasis patients. [Extracted from the article]

A new report presents fresh data on menthol therapy and its impact on smoking cessation intentions among African American/Black individuals. The study explores how African American/Black individuals who smoke menthol cigarettes would respond to flavor bans and how to enhance the intended benefits. The research suggests that culturally specific cessation strategies that emphasize the health-related benefits of quitting, particularly featuring the experiences of people who successfully quit, may help African American/Black individuals quit smoking following a menthol ban. The study also highlights the importance of providing information on the health hazards and costs of smoking, as well as addressing concerns over weight gain. [Extracted from the article]

A recent study conducted by researchers at the State Key Laboratory of Trauma has shed light on the progression of glaucoma and potential treatment options. Glaucoma, a leading cause of blindness worldwide, is characterized by the degeneration of retinal ganglion cells (RGCs). While reducing intraocular pressure (IOP) is a common method to prevent RGC cell death, it does not always prevent degeneration. The study found that optic nerve defects occur before retina damage in glaucoma, and oligodendroglial lineage cells play a role in the subsequent neuropathology. Treatment with clemastine, an FDA-approved antihistamine, showed promising results in attenuating optic nerve and retina damage by promoting oligodendrocyte precursor cell differentiation and enhancing remyelination. This research provides valuable insights into the timeline of optic neuropathies in glaucoma and suggests a potential therapeutic strategy for demyelination-associated glaucoma. [Extracted from the article]

A patent application by Bayer Healthcare LLC has been made available online for a high concentration suspension formulation for cold and flu soft gel capsule medications. The invention aims to provide smaller dosage forms of these medications, which are more convenient and pleasant for consumers to take. The soft gel capsules contain a suspension with specific amounts of acetaminophen, dextromethorphan HBr, phenylephrine HCl, and optional additional active pharmaceutical ingredients. The method for preparing the soft gel capsules involves combining various ingredients and encapsulating the suspension with an outer shell mixture. [Extracted from the article]

A recent study conducted by researchers at the Legal Medicine Research Center in Tehran, Iran, has found that herbal supplements for weight gain may contain undeclared active pharmaceutical ingredients, specifically cyproheptadine, at concentrations higher than the therapeutic dose. The study highlights the lack of regulation for herbal supplement production in Iran and emphasizes the need for quality control and safety measures to protect patients' health. The researchers used gas chromatography/mass spectrometry to detect the presence of cyproheptadine in a weight gain herbal supplement purchased from an online shop. This information is important for individuals who rely on herbal medicine for their healthcare needs and underscores the importance of ensuring the efficacy and safety of these products. [Extracted from the article]

A study conducted by researchers from Hashemite University in Zarqa, Jordan, has developed a new method for detecting parabens in biological samples. Parabens are antimicrobial preservatives commonly found in cosmetics, toiletries, pharmaceuticals, and food. The researchers utilized a new hydrophobic deep eutectic solvent (DE) composed of menthol and tris(2-ethylhexyl) phosphate (M-TEHP) to enhance the extraction capacity and eco-friendliness of the solvent. The optimized method, combined with HPLC-DAD, demonstrated low detection limits, excellent linearity, precise results, satisfactory recoveries, and negligible matrix effects, making it effective for determining parabens in real urine and plasma samples. [Extracted from the article]

A recent study conducted by researchers at Peking University Health Science Center in Beijing, China, has explored the role of certain ion channels in paclitaxel-induced peripheral neuropathic pain (PIPNP). The study found that the expression and activity of the TRPV1 ion channel, which is involved in nociception and heat sensing, were increased in rat dorsal root ganglion neurons in PIPNP. Conversely, the expression and activity of the TRPM8 ion channel, which is involved in cold sensing, were decreased. The study suggests that inhibiting TRPV1 function and activating TRPM8 may have analgesic effects in PIPNP, with menthol being a potential treatment option. [Extracted from the article]

A recent report from the School of Pharmacy highlights the potential benefits of handmade soaps in promoting skin health and well-being. The research focuses on enhancing the quality of handmade soaps by incorporating emollients such as cocoa butter, shea butter, and mango butter. These natural ingredients offer a safer alternative to mass-produced soaps that may contain harmful chemicals. The study emphasizes the importance of natural ingredients and suggests that these innovative emollient-based soap formulations have commercialization potential, providing consumers with a safer and more customizable skincare option. [Extracted from the article]

This document provides information about a clinical trial conducted at Erzurum Ataturk University Health Application and Research Center in Turkey. The trial aims to investigate the impact of using a menthol scent on patients during the postoperative awakening period. The study will include 30 experimental and 30 control group patients who will undergo laparoscopic cholecystectomy. The researchers will use the Alertness and Sedation Observer Assessment Scale (OAA/S) and Modified Aldrete Scoring to evaluate the patients' condition. The goal of the study is to reduce anxiety and confusion during the waking period after anesthesia and improve the patient's reanimation process. The study is currently recruiting participants and is expected to be completed in July 2024. [Extracted from the article]

A recent study conducted by the Food and Drug Administration (FDA) investigated the effects of different levels of menthol in cigarettes on nicotine pharmacology and smoking topography in current menthol smokers. The study found that varying menthol content did not significantly impact nicotine's pharmacological effects or smoking topography in an acute laboratory setting. However, menthol at concentrations reflecting the marketplace (3-6 mg) contributed to positive subjective smoking experiences among menthol smokers. These findings suggest that menthol's flavor and sensory effects play a role in product preference and positive smoking experiences, which can lead to repeated experimentation, regular use, and dependence. [Extracted from the article]

A recent report from the Faculty of Pharmacy in Cairo, Egypt discusses the development of a green high-performance liquid chromatography (HPLC) method for the simultaneous quantitation of paracetamol, chlorpheniramine maleate, caffeine, and ascorbic acid in their pharmaceutical dosage form. The researchers used a design of experiment approach to optimize the chromatographic separation of the multicomponent mixture. The study found that the optimized method achieved a chromatographic separation in less than 6 minutes with a desirability of 0.999. The research also evaluated the greenness profile of the method, which showed favorable results. [Extracted from the article]

Researchers at the Postgraduate Institute of Medical Education and Research have released a new study on cyproheptadine therapy. Cyproheptadine is an over-the-counter antihistamine often used as an appetite stimulant. While it is generally safe, rare cases of drug-induced liver injury have been reported. The study presents a case of cholestatic liver injury secondary to cyproheptadine in a young pharmacy student with chronic hepatitis B and reviews the literature on cyproheptadine-induced liver injury. The researchers conclude that although cyproheptadine is mostly safe, its potential for significant liver toxicity should not be ignored. [Extracted from the article]

A study conducted by researchers at Tehran University of Medical Sciences in Iran compared the effectiveness of two sedative drugs, clemastine and midazolam, during colonoscopy procedures. The study found that clemastine was associated with lower pain levels after the procedure compared to midazolam. There were no significant differences in blood pressure or pulse rate between the two groups. Based on these results, the researchers concluded that clemastine can be used as a main sedative drug during colonoscopy. [Extracted from the article]

A recent study conducted at the Smt. B.K. Shah Medical Institute and Research Centre examined the use of cyproheptadine in the treatment of serotonin syndrome (SS). SS is a life-threatening condition caused by serotonergic agents, and cyproheptadine is a serotonin antagonist commonly used in its treatment. The study retrospectively evaluated 23 adult patients who met the criteria for SS and found that all patients showed some response to cyproheptadine within 24 hours of treatment. The researchers concluded that any response to cyproheptadine, even a partial one, within 24 hours could be an indicator of the presence of SS. [Extracted from the article]

A recent study conducted by Fukushima Medical University School of Medicine in Japan focused on the treatment of serotonin syndrome, a potentially life-threatening condition caused by the use of antidepressants or interactions with other serotonergic medications. The researchers used cyproheptadine, a specific treatment option, and measured the neurological pupil index (NPi) as an indicator of the severity of the syndrome. The patient in the case study was discharged after seven days, but the researchers were unable to determine a clear relationship between NPi and the severity of serotonin syndrome. Further research is needed in this area. [Extracted from the article]