1. Langerhans cell histiocytosis mimicking acute dacryocystitis.
- Author
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Guàrdia-Ruiz N, López-Miñarro IM, Obregón-Martínez E, and Asensio-Sánchez VM
- Subjects
- Humans, Diagnosis, Differential, Child, Preschool, Acute Disease, Male, Antigens, CD analysis, Antigens, CD1, Histiocytosis, Langerhans-Cell diagnosis, Histiocytosis, Langerhans-Cell diagnostic imaging, Dacryocystitis diagnosis
- Abstract
Langerhans cell histiocytosis (LCH) is a myeloid neoplasm characterized by clonal neoplastic proliferation of Langerhans-type dendritic cells associated with an inflammatory infiltrate predominantly composed of lymphocytes and eosinophils. In this article, we present an unusual case of LCH with significant swelling in the left lacrimal sac region in a 3-year-old child, clinically mimicking acute dacryocystitis. Microscopically, it showed intense inflammatory infiltrate and histiocytes with irregular nuclei. The tumor cells were positive for S-100 protein, CD1a, and CD207 (langerin). Molecular study was positive for the V600E/E2/D mutation (EXON 15). This case emphasizes the importance of careful clinical, radiographic, and microscopic evaluation, as some neoplasms may mimic common benign lesions., (Copyright © 2024 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2024
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