1. TITAN Project: Microfluidic and Sensing Tools for Immunotherapy
- Author
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Maria Serena Chiriacò, Elisabetta Primiceri, Antonio Turco, Valeria Garzarelli, Giulia Siciliano, Alessia Foscarini, Ahmed Alsadig, Annunziata Carbonara, Benedetta Stampone, Gianluca Trotta, Marco Cereda, Marco de Tullio, Giuseppe Gigli, and Francesco Ferrara
- Subjects
CAR-T cell immunotherapy ,on-chip quality control ,microfluidic and sensing platform ,General Works - Abstract
The TITAN project aims to improve immunotherapy, targeting the efficiency of methods to obtain genetically engineered T cells. Immunotherapy has achieved great success in clinical trials, but it is currently very expensive in terms of time required for analysis, reagents, and samples. TITAN aims to the continuous sampling of critical quality attributes, in order to quickly recognize deviations from the desired range and take appropriate corrective actions on process parameters for an optimal outcome. To achieve its aims, TITAN is currently developing microfluidic and sensing tools for the accurate and efficient real-time monitoring of the T cells amplification process.
- Published
- 2024
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