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Introduction From the beginning of the COVID-19 pandemic, healthcare workers had to face unprecedented emergency needs associated with an extraordinary amount of psychological distress. In this cross-sectional multicenter study, we investigated sleep disturbances, and the level of anxiety and depression among the healthcare and non-healthcare staff of three hospitals in Milan (Italy) during the COVID-19 outbreak. Moreover, we explored potential predisposing factors for affective symptoms and poor sleep. Methods Between June and July 2020, we administered an online questionnaire to evaluate the presence of sleep disorders (Pittsburgh Sleep Quality Index), insomnia (Sleep Condition Indicator), anxiety (State Trait Anxiety Inventory), and depression (Beck Depression Inventory-II). We used univariate and multivariate analysis to evaluate the association between the personal conditions and sleep and affective disorders. Results The 964 participants reported high rates of sleep disorders (80.3%)—mainly insomnia (30.5%)—anxiety (69.7%), and depression (32.8%). The multivariate analysis showed a strong association of sleep disorders, especially insomnia, with female gender (p = 0.004), divorced marital status (p = 0.015), self-isolation (p = 0.037), and chronic diseases (p = 0.003). Anxiety was significantly associated with teleworking (p = 0.001), while depressive symptoms were associated with self-isolation (p = 0.028), modified work schedules (p = 0.03), and chronic diseases (p = 0.027). Conclusion In hospital workers, the high prevalence of sleep and psychiatric symptoms during the COVID-19 outbreak appears to be determined mainly by modifications of personal or work habits. Teleworking was associated with increased anxiety. An accurate planning of hospital activities and a psychological support are needed to prevent and manage sleep and mental disorders.

STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) in myotonic dystrophy type 1 is mostly of central origin but it may coexist with sleep-related breathing disorders. However, there is no consensus on the sleep protocols to be used, assessments vary, and only a minority of patients are regularly tested or are on treatment for EDS. Our study presents data on self-reported and objective EDS in adult-onset myotonic dystrophy type 1. METHODS: Sixty-three patients with adult-onset DM1 were subjected to EDS-sleep assessments (polysomnography, Multiple Sleep Latency Test, Epworth Sleepiness Scale). Correlation coefficients were computed to assess the relationship between sleep and sleepiness test results, fatigue, and quality of life. RESULTS: 33% and 48% of patients had EDS based, respectively, on the Epworth Sleepiness Scale and the Multiple Sleep Latency Test, with a low concordance between these tests (k = 0.19). Thirteen patients (20%) displayed 2 or more sleep-onset rapid eye movement periods on Multiple Sleep Latency Test. Patients having EDS by Multiple Sleep Latency Test had a shorter disease duration (P < .05), higher total sleep time and sleep efficiency and lower wake after sleep onset on polysomnography. Patients with self-reported EDS reported significantly higher fatigue score compared with patients without EDS (P < .05). No other difference was found in demographic, clinical, and respiratory features. CONCLUSIONS: EDS test results are contradictory, making treatment options difficult. Combining quantitative tests and self-reported scales may facilitate physicians in planning EDS care with patients and families. CITATION: Sansone VA, Proserpio P, Mauro L, et al. Assessment of self-reported and objective daytime sleepiness in adult-onset myotonic dystrophy type 1. J Clin Sleep Med. 2021;17(12):2383–2391.

The aim of this article is to question the nature of the socio-anthropological approach in Lefort’s thought. The author explores the complex relationship between Lefort and the Durkheimian French school of sociology in four stages: in the first, he shows Lefort as a sociologist ‘worthy of its name’ or, in other words, a sociologist interested in questioning the ‘institution of the social’. In the second, he focuses on the disturbing elements that Lefort introduces: the political and the division into the French sociological approach. In the third stage, he focuses his attention on the sociological approach in Lefort’s way of thinking about democratic society. Finally, he concludes by referring to Lefort’s apparent opposition between philosophy and social sciences – and the errors that this may have engendered – in order to demonstrate the continuity of Lefort’s sociological approach.

The viral pandemic caused by Covid-19 changed the daily routine of people, as well as companies, whether public or private. Extreme measures have become necessary to contain the spread of the virus, and social isolation must be promoted. This reality affected the already overloaded Brazilian Judicial System, requiring the modernization and improvement of services provided to society. Thus, the aim of this study was to understand entrepreneurship as innovation in the public sector, especially in the judiciary. The methodology used to develop the work was the literature review, through consultations with books, legislation, publications of the Brazilian Government and articles published in journals in the area. It can be concluded that the pandemic accelerated the process of modernization of the public sector, especially the judiciary, using tools such as telework and artificial intelligence. Therefore, it was observed that it is necessary entrepreneurship and strategic planning for these sectors to be able to function efficiently, with these new technologies, to provide a quality service, even in the face of a state of public calamity. La pandemia viral provocada por el Covid-19 cambió la rutina diaria de las personas, así como de las empresas, ya sean públicas o privadas. Se han hecho necesarias medidas extremas para contener la propagación del virus y se debe promover el aislamiento social. Esta realidad afectó al ya sobrecargado Sistema Judicial Brasileño, requiriendo la modernización y mejora de los servicios prestados a la sociedad. Así, el objetivo de este estudio fue entender el emprendimiento como innovación en el sector público, especialmente en el poder judicial. La metodología utilizada para desarrollar el trabajo fue la revisión de la literatura, a través de consultas con libros, legislación, publicaciones del Gobierno brasileño y artículos publicados en revistas del área. Se puede concluir que la pandemia aceleró el proceso de modernización del sector público, especialmente del poder judicial, utilizando herramientas como el teletrabajo y la inteligencia artificial. Por lo tanto, se observó que es necesario el emprendimiento y la planificación estratégica para que estos sectores puedan funcionar de manera eficiente, con estas nuevas tecnologías, para brindar un servicio de calidad, incluso frente a un estado de calamidad pública. A pandemia viral causada pelo Covid-19 alterou a rotina diária das pessoas, assim como das empresas, sejam elas públicas ou privadas. Medidas extremas se tornaram necessárias para conter a disseminação do vírus, sendo preciso promover um isolamento social. Essa realidade afetou o já sobrecarregado Sistema Judiciário brasileiro, exigindo a modernização e melhoria dos serviços prestados à sociedade. Sendo assim, o objetivo desse estudo foi compreender sobre o empreendedorismo como inovação no setor público, em especial no poder judiciário. A metodologia utilizada para desenvolver o trabalho foi a revisão bibliográfica, através de consultas a livros, legislações, publicações do Governo Brasileiro e artigos publicados em periódicos da área. Pode-se concluir que a pandemia acelerou o processo de modernização do setor público, em especial do poder judiciário, com uso de ferramentas como teletrabalho e inteligência artificial. Para tanto, observou-se que é necessário empreendedorismo e planejamento estratégico para que estes setores consigam funcionar de forma eficiente, com essas novas tecnologias, para prestar um serviço de qualidade, mesmo diante de um estado de calamidade pública.

O presente artigo, construído por meio de pesquisa bibliográfica, documental e de experiência profissional, considerando a possibilidade de analisar indicadores que ainda não receberam tratamento científico, tem, como objetivo, discutir sobre a gestão hospitalar no que toca à segurança do paciente a partir do trabalho desenvolvido no Hospital Geral de Barcelos/AM. O interesse pelo debate proposto se justifica em função do conhecimento, propiciado pela prática profissional, de que todos os pacientes admitidos em um serviço de saúde estão sujeitos a determinados incidentes relacionados à assistência hospitalar (que não estão vinculados à sua doença de base), situação que pode afetar a saúde e recuperação dos usuários desta política pública. Pode-se citar, como exemplo desta realidade, os pacientes que realizam cirurgias para remoção de cálculos na vesícula biliar, os quais estão expostos, após o procedimento cirúrgico, a uma queda da maca durante o transporte do Centro Cirúrgico para a enfermaria, levando à fratura do fêmur, o que pode, consequentemente, resultar na prolongação do tempo de internação. Como forma de reduzir estas e outras situações de risco, o Programa Nacional de Segurança do Paciente (PNSP) foi lançado no Brasil em 2013, tendo contribuído para a qualificação dos cuidados com a saúde em todos os estabelecimentos do país, destacando o trabalho da gestão local e dos profissionais atuantes na unidade hospitalar em questão, o qual, atualmente, responde pelos maiores cuidados com a saúde neste território. Nesta perspectiva, será evidenciada, como principal resultado na segurança do paciente, a implantação das ações do PNSP no município de Barcelos/AM, bem como versa-se sobre a organização de um checklist contendo o passo a passo a ser seguido pelos profissionais, intervenção esta que tem contribuído para a diminuição dos riscos ao público, direcionada, sobretudo, aos equipamentos de saúde nesta localidade.

A pesquisa teve como objetivo principal discorrer sobre a importância do controle interno no setor público, com base em bibliografia peculiar da área. Visa-se especificar melhor a temática a partir da descrição de conceitos e definições sobre a administração e o controle interno, assim como versa sobre a legislação que ampara o controle interno no Brasil. Na sequência, apresenta-se como ferramenta de gestão pública no contexto socioeconômico atual. A metodologia utilizada foi a revisão bibliográfica, buscando-se promover a reflexão dialógica, apoiando-se, para tanto, nos principais autores que conceituam a temática abordada. Como resultado, nota-se que o controle interno é indispensável para Administração Pública em todos os seguimentos, pois atua como um fator de inibição do mau uso dos serviços intrínsecos que propõe diariamente. Consiste em uma busca que apresenta mecanismos capazes de inibir os fracassos de uma gestão atualmente corruptível e fraudulenta. Considera-se, também, que o controle interno precisa renovar-se continuamente, buscando-se por novos parâmetros de atuação, por se tratar de uma ferramenta falível aos olhos de governantes viciosos. Este estudo configura-se como descritivo, e, como tal, tem as suas características e limitações. Não tem-se como pretensão esgotar a temática, ou, ainda, inferir respostas para todos os questionamentos suscitados pela problemática de pesquisa. Trata-se de uma análise crítica-reflexiva que, com base na literatura específica, disserta sobre a relevância do controle interno na dimensão da Gestão Pública.

Este estudo visa destacar os aspectos conceituais sobre o conhecimento científico e gestão do conhecimento. Assim, a pesquisa teve como objetivo principal compreender as práticas de gestão do conhecimento pelos bibliotecários do Sistema Integrado de Bibliotecas da Universidade do Estado do Amazonas (SIB/UEA). O estudo demonstrou quais as práticas exercidas pelos Bibliotecários do Sistema são serviços públicos e qual sua eficácia no processo de compartilhamento de informações e serviços para a sociedade. Este assunto é de grande relevância, principalmente para a comunidade acadêmica, uma vez que este é o universo que permeia todas as áreas de conhecimento, sendo, portanto, indispensável à todos aqueles que buscam aprimorar seus conhecimentos. No tocante à metodologia, parte-se de um estudo de caso, com a aplicação do questionário nas bibliotecas do SIB/UEA. Os resultados mostraram que o SIB/UEA é composto por muitos profissionais capacitados que fazem uso das práticas de Gestão do Conhecimento no seu cotidiano dentro das bibliotecas do Sistema e que, com elas, promovem outros serviços, atendendo, de forma isonômica, tanto o público interno das bibliotecas quanto a sociedade na localidade em que estão inseridos. Com base nos resultados obtidos, foi possível identificar e destacar as principais atividades de GC que os bibliotecários do SIB/UEA fazem uso e que são, consequentemente, serviços públicos. Por fim, vê-se a transformação de biblioteca convencional em uma biblioteca eletrônica ou digital. Esta é uma atividade que atua diretamente com as questões de geração da GC, viabilizando a atualização da biblioteca na sociedade atual e, também, torna mais fácil o acesso às informações científicas, que serão disponibilizadas para uso interno da universidade, como, também, para toda a população, que poderá fazer uso deste serviço.

Na cidade de Manaus temos a chamada Zona Franca, conglomerado de empresas beneficiadas por incentivos fiscais que fomentaram a movimentação financeira e populacional no estado do Amazonas. Esse giro econômico representa cerca de 80% da economia local, ou seja, faz-se necessária uma alterativa a fim de obter um maior equilíbrio para ampliar novas fontes de receita, geração de emprego e renda para um futuro próspero. O Polo Digital surge como protagonista para somar com a Zona Franca de Manaus, fazendo com que haja uma expansão de mercado, fortalecimento econômico e desenvolvimento local. O Polo Digital possui como vertente a sinergia entre universidades, governo, comércio e empresas. Há em pauta a importância da Gestão Pública como meio necessário para impulsionar o desenvolvimento desse projeto que propiciará ganhos às áreas de Pesquisa, Desenvolvimento e Inovação. Além do crescimento de empreendimentos locais, tem-se, como ganho para a Administração Pública, uma boa arrecadação, gerando-se investimentos nas diversas frentes necessárias para o bem-estar social dos moradores de Manaus. O Polo Digital é uma saída fundamental para uma cidade referência. Uma vertente fundamental do Polo Digital chama-se estudo de cenário, algo necessário para que Manaus tenha como se preparar e criar ambiente propício no que tange ao desenvolvimento socioeconômico regional e para ser reconhecida como cidade autossustentável, com capacidade de fornecer soluções científicas, tecnológicas, dentre outras.

Summary Within Husserl’s theory of perception, the role attributed to kinesthetic sensations determines a phase of the perceptive constitution that marks the boundary between pure receptivity and a first form of self-determination of consciousness. Kinesthetic experiences are, in fact, characterized not just as acts that are performed but rather that can be performed, albeit according to predetermined paths. This primitive form of ‘instinctive’ spontaneity of the Ego (linked to primal impulses) as realization of pre-established potentialities, characterizes what Husserl defines the ‘ idiopsychic’ dimension of consciousness (Husserl, 1952, p. 135). However, although this level of consciousness unity presupposes a spontaneous activity, it can be investigated according to the ‘causal’ laws of motivation. The phenomenon of motivation was notoriously introduced by Husserl in §56 of Ideen II, as a specific law of spiritual life. However, there are two possible forms of motivation, one in which the Ego is actively involved, and a second one, called “associative motivation.” The latter basically indicates the passive tendency of creating associations between unities of the immanent sphere. In other terms, Husserl acknowledges the existence of “motivated relations” within the immanent sphere of mental acts which do not necessarily call for an active participation of the Ego. In this sense, the relation between motivating factors and motivated elements could be considered a kind of conditioning of the form “because-therefore,” in which the two elements arrange themselves in a succession of experiences. This work aims to show that this very kind of association is the same that pre-determines the unfolding possibility of kinesthetic chains.

O objetivo deste trabalho é apresentar um breve panorama da Agenda Ambiental da Administração Pública (A3P) e analisar seu papel como ferramenta macropolítica de Gestão Ambiental pública em escala local, sua aderência pelo Instituto Federal do Amazonas – IFAM. O presente estudo consistiu no levantamento teórico-bibliográfico da questão socioambiental, levantamento de dados por meio de consulta ao site do Ministério do Meio Ambiente além da pesquisa in loco. Para análise dos dados coletados foram utilizados métodos misto, com predominância qualitativa. A A3P é um programa de Gestão Ambiental institucional para o setor público, e, possui amplitude nas normas/acordos internacionais e nacionais. O panorama demonstra moderada aderência à Agenda pelas instituições públicas, sendo a esfera Federal destaque em adesões e premiações. A pesquisa revela que no IFAM, os resíduos gerados pela instituição precisam de melhor atenção, assim como os resíduos perigosos. Outra oportunidade de melhorias percebida são os investimentos em energias renováveis e o monitoramento do consumo da água. As licitações sustentáveis teve como ponto positivo a aderência ao pregão eletrônico, porém, ainda não é institucionalizada plenamente. A aderência da Agenda no IFAM foi percebida como parcial.

Due to the exponential growth of the number of subjects affected by coronavirus disease 2019 (COVID-19), the entire Italian health care system had to respond promptly and in a very short time with the need of semi-intensive and intensive care units. Moreover, trained dedicated COVID-19 teams consisting of physicians were coming from different specialties (intensivists or pneumologists and infectiologists), while respiratory therapists and nurses have been recruited to work on and on without rest. However, due to still limited and evolving knowledge of COVID-19, there are few recommendations concerning the need in respiratory rehabilitation and physiotherapy interventions. The presentation of this paper is the result of a consensus promoted by the Italian societies of respiratory health care professionals who contacted pulmonologists directly involved in the treatment and rehabilitation of COVID-19. The aim was to formulate the more proper and common suggestions to be applied in different hospital settings in offering rehabilitative programs and physiotherapy workforce planning for COVID-19 patients. Two main areas of intervention were identified: organization and treatment, which are described in this paper to face the emergency.

A pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 was declared in 2020. Severe cases were characterized by the development of acute hypoxemic respiratory failure (AHRF) requiring advanced respiratory support. However, intensive care units (ICU) were saturated, and many patients had to be treated out of ICU. This case describes a 75-year-old man affected by AHRF due to Coronavirus Disease 2019 (COVID-19), hospitalized in a high-dependency unit, with PaO2/FiO2

Background : Cutaneous tumors are rarely described in avian and are frequently of viral origin. Solid tumors of vascular origin are seldom reported and usually result in difficult management by surgery alone. We describe the outcome of a subcutaneous low-grade epithelioid hemangioendothelioma (EHE) treated with the combination of surgery and electrochemotherapy. Case Description : A 10-year-old male budgerigar parakeet ( Melopsittacus undulatus ) was referred for evaluation of a 2-month non-healing exophytic mass on the left wing. The bird was bright, alert, and responsive, with a 2 × 1 cm proliferative lesion on the wing. Signs of discomfort were elicited by the clinical manipulation of the wing; no other abnormalities were detected during physical evaluation. Following hematological and imaging analysis, the parakeet was anesthetized and the mass was surgically removed. The histopathology report came back with a diagnosis of incompletely excised subcutaneous low-grade EHE. A surgical revision was not feasible due to the anatomical location and tumor extension. Adjuvant electrochemotherapy was chosen to increase the chance of tumor control. Two sessions of electrochemotherapy were performed with a 2-week interval between treatments using intralesional bleomycin followed by trains of permeabilizing electric pulses. Side effects were not observed and the parakeet was disease-free for 12 months when he died of acute renal failure. Conclusion : In lieu of the incomplete surgical excision of the tumor, electrochemotherapy resulted in good local control and cosmetic appearance and should be added to the standard oncological therapies for avian. Keywords : Avian, Biphasic electric pulses, Bleomycin, Electrochemotherapy, Parakeet.

The first part of this contribution is devoted to a critical analysis of Le liberta del lavoro, second volume of the series Quaderni dell societa italiana di storia del lavoro, edited by Laura Cerasi. The second part focuses on a theme neglected in that volume: the need for a re-assessment of the end of Marxism as a condition for a fresh look at the nature and role of socio-economic conflict.

We describe and implement a data selection algorithm aimed at identifying background atmospheric CO2 observations from in situ continuous measurements. Several selection criteria for detecting the background data have been developed and are currently used: the main objective of this work was to define a common methodology to extract the atmospheric background signal minimizing heterogeneities due to the use of different selection algorithms. The algorithm used in this study, (BaDS, Background Data Selection) was tested and optimized using data (from 2014 to 2018) from four Italian stations characterized by markedly different environmental conditions (i.e., mountain, coastal and marine): Plateau Rosa (PRS), Mt. Cimone (CMN), Capo Granitola (CGR) and Lampedusa (LMP). Their locations extend from the Alps to the central Mediterranean. The adopted algorithm proved to be effective in separating the local/regional from the background signal in the CO2 time series. About 6% of the data at LMP, 11% at PRS, 20–38% at CMN and 65% at CGR were identified as non-background. LMP and PRS can be used as reference sites for the central Mediterranean, while CMN and CGR were more impacted by regional sources and sinks. Finally, we discuss a possible application of BaDS screened data.

The Mediterranean basin is considered a global hot-spot region for climate change and air-quality. CO2 is the single most-important anthropogenic greenhouse gas (GHG) in the atmosphere, accounting approximatively for ∼63% of the anthropogenic radiative forcing by long-lived GHG. According to Le Quérée et al. (2018), the increasing of the atmospheric CO2 mixing ratios in the global atmosphere is driven by fossil fuel and cement production.In order to reduce GHG emissions and taking into account the needs for economy and society development, schemes of regulation and emission trading have been adopted at international, national, and city levels. The implementation of these regulation, to achieve the goal successfully, needs scientific evidence and information provided on consistent datasets. In the last year, efforts are dedicated to set up harmonized reference networks at difference scales (WMO/GAW, AGAGE, ICOS).In this work, we analysed a set of continuous long-term measurements of CO2 carried out at 4 atmospheric observatories in Italy belonging to the WMO/GAW network and spanning from the Alpine region to central Mediterranean Sea: Plateau Rosa (western Italian Alps, 3480 m a.s.l.), Mt. Cimone (northern Apennines, 2165 m a.s.l.), Capo Granitola (southern Sicily coastline) and Lampedusa Island. Mt. Cimone is also a “class-2” ICOS station, while Plateau Rosa and Lampedusa are in the labelling process. Starting time of GHG observations range from 1979 for Mt. Cimone to 2015 for Capo Granitola. Due to their different locations and ecosystems, they provide useful hints to investigate CO2 variability on different latitudinal and altitudinal ranges in the Mediterranean basin and to study of natural and anthropogenic-related processes able to affect the observed variability.The study addresses primarily differences in daily and seasonal cycles at the different sites, and implemented a procedure to identify background conditions called BaDSfit (Background Data Selection for Italian stations; Trisolino et al., submitted). This methodology was originally used at Plateau Rosa station (Apadula, 2019) and it is based on the Mauna Loa data selection method (Tans and Thoning, 2008). BaDSfit consist of three steps and an optimization of the procedure was carried out with a sensitivity study. Marked differences among the daily cycles at the various sites exist. The effect of the data selection on the seasonal and diurnal cycle and long-term evolution is investigated. The BaDSfit lead to a more coherent diurnal and seasonal evolution of the different datasets, is able to identify background condition and allows the separation of local/regional scale from large scale phenomena in the CO2 time series.

Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR) On February 2020, Italy, especially the northern regions, was hit by an epidemic of the new SARS-Cov-2 coronavirus that spread from China between December 2019 and January 2020. The entire healthcare system had to respond promptly in a very short time to an exponential growth of the number of subjects affected by COVID-19 (Coronavirus disease 2019) with the need of semi-intensive and intensive care units.

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Backgrounds Mask-related side effects can negatively influence adherence to continuous positive airway pressure (CPAP). Nasal pillows (P) can be an alternative to the standard nasal masks (N), although there are no data about their long-term efficacy. This study aimed to assess long-term effectiveness and adherence to CPAP therapy delivered with nasal pillows in obstructive sleep apnea syndrome (OSAS) patients. Methods A retrospective observational design involving a series of consecutive CPAP-naive patients affected by OSAS. After an initial mask fitting session all patients were allowed to choose the type of nasal interface (N or P) they preferred. Outcomes were assessed 5 days after CPAP titration, and after 2 and 12 months. Patients were offered the option of switching to an alternative mask if needed. Results Data from 144 patients were analyzed. Subjects were predominantly male (76%), middle aged (58.14 ± 12.86), moderately obese (body mass index: 33.89 ± 7.56), and affected by severe OSAS (apnea-hypopnea index: 47.60 ± 21.31). A total of 102 patients (70.8%) chose P, and 42 (29.2%) chose N. Clinical and polygraphic features, and CPAP pressure levels were similar in P and N groups, both at baseline and at 12 months. A good adherence to treatment was observed in both groups (P, 5.5 ± 1.8 h; N, 5.3 ± 1.5 h). Seventy-six patients (53%) reported at least one side effect during the whole study period, without statistically significant between-group differences. Nostril pain was the most frequent side effect in P. Conclusions Nasal pillows showed equal long-term effectiveness and objective adherence as standard nasal masks.

Endometriosis is a chronic gynecological disease characterized by the ectopic proliferation of endometrial tissue outside of the uterine cavity. The pathogenesis of this disease is still obscure, and Sampson’s theory of retrograde menstruation is still the most widely accepted explanation. Endometriosis in animals has been so far described not only in baboons and a rhesus macaque but also in dogs and horses that are nonmenstruating animals. In this article, we report the histological and immunohistochemical characterization of the first case of ovarian cystic endometriosis and adenomyosis in a guinea pig. The case presented supports the hypothesis that endometriosis is a disease not at all related to the phenomenon of retrograde menstruation but is a consequence of some alterations in the morphogenesis of the female genital system and therefore it could be found in any mammal. We suggest considering endometriosis among the other pathological phenotypes in animals displaying ovarian and uterine alterations and having a history of difficulties in conceiving.

We investigate how resource orchestration influences performance within the ‘knowledge resource management’ approach by exploiting a novel database on the Italian Serie A top-professional football league spanning from the 1960–61 up to the 1991–92 season. We find that the acquisition of experience via newcomers has a U-shaped non-monotonic relationship with performance. Furthermore, we find that releasing co-specialized employees has a positive moderating role within the relationship between team experience and performance by suggesting that dismissing old routines positively influences the relationship between current routines and team's performance.

Two male rats (Rattus norvegicus; 18 and 24 months old), were referred for treatment of large masses located in the axillary area. Following total body radiography and hematological and serum biochemical analysis, the rats were anesthetized, and the masses were surgically removed. Both lesions were diagnosed as mammary carcinoma based on histopathological diagnosis. The tumor beds were treated with two sessions of electrochemotherapy (ECT), two weeks apart. ECT involved cisplatin administration in the tumor bed, followed by a series of eight biphasic electric pulses. The treatment was well tolerated, and the rats were disease-free after 10 and 14 months. Therefore, adjuvant ECT resulted in good local control of mammary carcinoma and can potentially be used for adjuvant treatment of pet rats with cutaneous and adnexal tumors.

The Plateau Rosa Alpine station (Italy) has collected atmospheric concentrations of carbon dioxide since 1989. If the complete set of hourly data is observed, two distinct and exceptional very high concentration events are evident for February 2004. Similar and almost contemporary peaks were registered at the European high–altitude stations of Zugspitze–Schneefernerhaus and Sonnblick in the Alps, and at Mt. Cimone in the Northern Apennines. A regional meteorological model (the Weather Research and Forecast) was applied over a medium–high resolution grid to study the evolution of the meteorological fields and to identify the trajectories of the polluted air masses during the CO2 observed peaks. The results show that, during both episodes, atmospheric circulation conveyed highly polluted air from the European plains to the Alpine stations. This conclusion has been also confirmed through concentration measurements of the atmospheric trace gases in the same area.