15 results on '"Ana Ortola Buigues"'
Search Results
2. Impacto del inicio de la monitorización flash de glucosa en la calidad de vida y en los parámetros de control glucémico de pacientes adultos con diabetes tipo 1
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Esther Delgado Garcia, Sofía del Amo Simón, María de la O Nieto de la Marca, Gonzalo Diaz Soto, Rebeca Jiménez-Sahagún, Emilia Gómez Hoyos, Juan José López Gómez, Daniel Antonio de Luis Román, Beatriz Torres Torres, Ana Ortola Buigues, and Marta Sánchez Ibáñez
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Nutrition and Dietetics ,Endocrinology ,Endocrinology, Diabetes and Metabolism - Abstract
Resumen Introduccion La monitorizacion flash de glucosa (MFG) mejora algunas variables de control glucemico y parametros de calidad de vida. Objetivo Evaluar la calidad de vida y el control glucemico tras el inicio de MFG en pacientes con DM1 en la practica clinica. Material y metodos Estudio observacional prospectivo en pacientes con DM1 que iniciaron MFG (de junio de 2019 a abril de 2020). Se evaluaron las puntuaciones de: cuestionario de calidad de vida especifico para la diabetes mellitus (EsDQOL), escala de distres relacionado con la diabetes (EsDDS), Diabetes Treatment Satisfaction Questionnaire (EsDTSQ) y variables de control glucemico al inicio y a los 3 meses de MFG. Resultados Se selecciono a 114 pacientes, el 56% varones, con una edad media de 37,2 anos (DE 12,4) con 18,7 anos (DE 11,5) de DM1. El 24,6% tenia infusion subcutanea continua de insulina. Se observaron diferencias (basalmente vs. 3 meses) en la puntuacion de EsDTSQ (22 [15,5-27] vs. 25 [22-28]; p Conclusiones El inicio de la MFG, asociado a un programa educativo estructurado, en pacientes adultos con DM1, se asocio a mejoria en la calidad de vida y a mayor satisfaccion con el tratamiento de la diabetes. Se observo mejoria en la HbA1c y menor numero de eventos de hipoglucemia, pero no hubo efectos en el resto de los parametros glucemicos.
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- 2022
3. Influencia del estado nutricional sobre la estancia media hospitalaria en el paciente con diabetes mellitus tipo 2
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Rebeca Jiménez Sahagún, Susana García Calvo, Beatriz Torres Torres, Juan José López Gómez, Cristina Serrano Valles, Ana Ortola Buigues, Emilia Gómez Hoyos, and Daniel Antonio de Luis Román
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0301 basic medicine ,03 medical and health sciences ,030109 nutrition & dietetics ,0302 clinical medicine ,Nutrition and Dietetics ,Endocrinology ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism - Abstract
Resumen Introduccion En el paciente hospitalizado la diabetes mellitus tipo 2 (DM2) puede condicionar una peor situacion nutricional debido a su fisiopatologia y tratamiento dietetico prescrito. Objetivos Valorar si el paciente con DM2 hospitalizado tiene peor situacion nutricional que el no diabetico. Determinar la influencia de la DM2 en la estancia media en pacientes con mala situacion nutricional. Material y metodos Estudio transversal desde enero de 2014 hasta octubre de 2016, en 1.017 pacientes en los que se solicito valoracion nutricional al servicio de endocrinologia y nutricion. Se recopilaron datos de antropometria, albumina plasmatica, demora en la realizacion de la interconsulta a nutricion y tiempo de estancia hospitalaria. Se analizo el estado nutricional mediante el cuestionario Mini Nutritional Assesment (MNA) y el indice de riesgo nutricional (IRN). Resultados Del total de pacientes el 24,4% eran pacientes con DM2 y 75,6% no lo eran. Los pacientes con DM2 presentaban mayor indice de masa corporal (23,18 [20,78-25,99] kg/m2 vs. 22,31 [19,79-25,30] kg/m2, p ˂ 0,01], menor puntuacion total del cuestionario MNA (16,5 [13,12-19]) puntos vs. 17 [14-20] puntos, p ˂ 0,01), menor puntuacion del indice IRN (83,09[77,72-91,12] puntos vs. 85,78 [79,27-92,83] puntos, p = 0,03). El paciente con DM2 tiene un riesgo aumentado de padecer malnutricion segun el cuestionario MNA ( Conclusiones Los pacientes con DM2 tienen peor situacion nutricional que los pacientes sin DM2. Los pacientes con diabetes con peor situacion nutricional presentan mayor estancia media hospitalaria.
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- 2020
4. Influence of nutritional status on the hospital length of stay in patients with type 2 diabetes
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Juan José López Gómez, Daniel Antonio de Luis Román, Emilia Gómez Hoyos, Cristina Serrano Valles, Ana Ortola Buigues, Beatriz Torres Torres, Susana García Calvo, and Rebeca Jiménez Sahagún
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0301 basic medicine ,medicine.medical_specialty ,030109 nutrition & dietetics ,business.industry ,Length of hospitalization ,030209 endocrinology & metabolism ,Nutritional status ,Type 2 diabetes ,Anthropometry ,medicine.disease ,03 medical and health sciences ,Malnutrition ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,In patient ,business ,Body mass index - Abstract
Introduction In the hospitalized patient, Diabetes mellitus type 2 (DM2) may result in a worse nutritional status due to its pathophysiology and dietary treatment. Objectives The aim of this study was to know if a hospitalized diabetic patient has a worse nutritional status, and to establish the influence of DM2 on the hospital length of stay in patients with malnutrition. Material and methods This was a transveral study from January 2014 to October 2016; 1017 patients were included who were assessed by the Endocrinology and Nutrition Department. The data collected included anthropometry, plasma albumin, delay in performing the nutrition interconsultation and hospital length of stay. Nutritional status was evaluated using the Mini Nutritional Assesment (MNA) questionnaire and the nutritional risk score (NRS). Results 24.4% of the patients were diabetic and 75.6% were not. Diabetic patients had a higher body mass index (BMI) [23.18 (20.78–25.99) kg/m2 vs. 22.31 (19.79–25.30) kg/m2, p Conclusions Diabetic patients have a worse nutritional status than non-diabetic patients. Diabetic patients with a poor nutritional status spend a longer period in hospital.
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- 2020
5. Aetiological diagnosis of hyponatraemia in non-critical patients on total parenteral nutrition: A prospective multicentre study
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Julia Álvarez Hernández, María Victoria García Zafra, Yaiza García Delgado, Luis Miguel Luengo Pérez, María Julia Ocón Bretón, María Dolores Ballesteros Pomar, Daniel Antonio de Luis Román, María Argente Pla, Angel Luis Abad Gonzalez, Emilia Gómez-Hoyos, Irene Bretón Lemes, Ana Herrero Ruiz, Francisco Botella Romero, Alejandra Herranz Antolín, Cristina Tejera Pérez, María Dolores del Olmo García, Alfonso Vidal Casariego, Isabelle Runkle de la Vega, Miguel Ángel Martínez Olmos, Pilar Matía Martín, Ana Ortola Buigues, Carmen Tenorio Jiménez, and Maria Jose Tapia Guerrero
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Male ,medicine.medical_specialty ,Cirrhosis ,endocrine system diseases ,Nausea ,Aetiology of hyponatraemia, Estímulo fisiológico de la secreción de AVP, Etiología de la hiponatremia, Nutrición parenteral, Parenteral nutrition, Physiological stimuli of AVP secretion, SIADH ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Urinary system ,Hypovolemia ,Renal function ,Pain ,Etiología de la hiponatremia ,Nutrición parenteral ,Gastroenterology ,Inappropriate ADH Syndrome ,Estímulo fisiológico de la secreción de AVP ,Endocrinology ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Aged ,Nutrition and Dietetics ,business.industry ,Aetiology of hyponatraemia ,SIADH ,nutritional and metabolic diseases ,medicine.disease ,Parenteral nutrition ,nervous system diseases ,Syndrome of inappropriate antidiuretic hormone secretion ,Urine osmolality ,Female ,Parenteral Nutrition, Total ,Physiological stimuli of AVP secretion ,medicine.symptom ,Diuretic ,business ,Hyponatremia - Abstract
BACKGROUND: In patients receiving total parenteral nutrition (TPN), the frequency of hyponatraemia is high. However, the causes of hyponatraemia in TPN have not been elucidated, although diagnosis is required for appropriate therapy. The aim of this study is to describe the aetiology of hyponatraemia in non-critical hospitalised patients receiving TPN. METHODS: Prospective multicentre study in 19 Spanish hospitals. Non-critically hyponatraemic patients receiving TPN and presenting hyponatraemia over a 9-month period were studied. Data collected included sex, age, previous comorbidities, and serum sodium levels (SNa) before and following TPN initiation. Parameters for study of hyponatraemia were also included: clinical volaemia, the presence of pain, nausea, gastrointestinal losses, diuretic use, oedema, renal function, plasma and urine osmolality, urinary electrolytes, cortisolaemia, and thyroid stimulating hormone. RESULTS: 162 patients were included, 53.7% males, age 66.4 (SD13.8) years. Volume status was evaluated in 142 (88%): 21 (14.8%) were hypovolaemic, 96 (67.6%) euvolaemic and 25 (17.6%) hypervolaemic. In 111/142 patients the analytical assessment of hyponatraemia was completed. Hypovolaemic hyponatraemia was secondary to GI losses in 10/111 (9%), and to diuretics in 3/111 (2.7%). Euvolaemic hyponatraemia was due to Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) in 47/111 (42.4%), and to physiological stimuli of Arginine Vasopressin (AVP) secretion in 28/111 (25.2%). Hypervolaemic hyponatraemia was induced by heart failure in 19/111 (17.1%), cirrhosis of the liver in 4/111 (3.6%). CONCLUSIONS: SIADH was the most frequent cause of hyponatraemia in patients receiving TPN. The second most frequent cause was physiological stimuli of AVP secretion induced by pain/nausea.
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- 2022
6. [A real-world study to evaluate a peptidic oral supplement in adults with altered intestinal function after parenteral nutrition]
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Esther Delgado, Beatriz Torres Torres, D.A. de Luis, Juan José López Gómez, Emilia Gómez Hoyos, Olatz Izaola, Ana Ortola Buigues, and David Primo Martín
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Male ,medicine.medical_specialty ,Time Factors ,Medicine (miscellaneous) ,Administration, Oral ,Body Mass Index ,Anthropometric parameters ,medicine ,Oral route ,Humans ,Prealbumin ,Prospective Studies ,Nutritional risk ,Serum Albumin ,Aged ,Gynecology ,Food, Formulated ,Nutrition and Dietetics ,Adult patients ,business.industry ,Dietary intake ,Body Weight ,Malnutrition ,Transferrin ,Nutritional status ,Nutritional survey ,Nutrition Surveys ,Intestinal Diseases ,Parenteral nutrition ,Dietary Supplements ,Patient Compliance ,Female ,Parenteral Nutrition, Total ,business ,Energy Intake ,Peptides - Abstract
espanolObjetivos: en la practica clinica habitual existen multitud de situaciones y patologias que pueden interrumpir la digestion y la absorcion intestinal, cursando con desnutricion y requiriendo el uso de suplementos orales nutricionales (SON). El objetivo de nuestro estudio fue evaluar, en el contexto de la vida real, el uso de un SON basado en peptidos, y el cumplimiento con el mismo, en pacientes adultos desnutridos con compromiso intestinal tras mas de 14 dias de nutricion parenteral. Material y metodos: el estudio se realizo en 44 pacientes desnutridos que requirieron nutricion parenteral total al menos 14 dias, sin utilizacion de la via oral durante el ingreso hospitalario. Se les administro de manera ambulatoria 1 brik al dia de Vital 1.5® para su consumo durante 12 semanas. Al inicio del tratamiento y tras el periodo de intervencion se les recogieron las variables siguientes: peso, talla, IMC, test de valoracion subjetiva global, bioquimica nutricional, encuesta nutricional, efectos adversos generados por la formula y cumplimentacion. Resultados: se incluyeron 44 pacientes con una edad media de 70,4 ± 10,4 anos (20 mujeres/24 hombres). Tras la intervencion aumentaron el IMC (0,51 ± 0,1 kg/m2; p = 0,02), el peso (1,4 ± 0,3 kg; p = 0,03), la prealbumina (3,5 ± 4,1 mg/dl; p = 0,01), la albumina (1,3 ± 0,1 mg/dl; p = 0,03) y la transferrina (71,5 ± 24,1 mg/dl; p = 0,02). La toma del SON represento a los 3 meses un 14,4 % del aporte calorico total de la dieta, un 17,5 % de los hidratos de carbono, un 12,9 % de las proteinas y un 12,3 % de las grasas. La cumplimentacion media del grupo fue del 87,7 ± 7,2 % de las tomas prescritas. En relacion a la situacion nutricional, a la entrada del estudio un 52,3 % (n = 23) de los pacientes presentaban en el test de valoracion subjetiva global la categoria B (malnutricion moderada o riesgo nutricional) y un 47,7 % (n = 21) la categoria C (desnutricion severa). Tras la intervencion, un 75 % de los pacientes presentaban la categoria A (buena situacion nutricional (n = 33), un 13,6 % (n = 6) de los pacientes presentaban la categoria B y un 11,4 % (n = 5) la categoria C. Conclusiones: la utilizacion de un suplemento peptidico con trigliceridos de cadena corta en pacientes ambulatorios tras haber recibido una nutricion parenteral total muestra un efecto beneficioso sobre los parametros bioquimicos y antropometricos, y la situacion nutricional, con una alta cumplimentacion y buena tolerancia. EnglishObjectives: in routine clinical practice many disorders are found that can disrupt the sequence of reactions in digestion and absorption, leading to malnutrition and requiring the use of oral nutritional supplements (ONS). The objective of our study was to evaluate in a real world setting the use of and compliance with a peptide-based ONS in malnourished adult patients with intestinal compromise after more than 14 days of parenteral nutrition. Material and methods: the study was carried out in 44 malnourished patients who required total parenteral nutrition for at least 14 days without using the oral route during their hospital stay. All patients were administered, on an outpatient basis, 1 brick per day of Vital 1.5® for 12 weeks. At the beginning of treatment and after the intervention period evaluated, the following variables were collected: weight, height, body mass index (BMI), global subjective assessment test, nutritional biochemistry, 3-day nutritional survey, adverse effects generated by the formula, and completion rate. Results: 44 patients were enrolled. Mean age was 70.4 ± 10.4 years (20 women & 24 men). After the intervention the following parameters had increased: BMI (0.51 ± 0.1 kg/m2; p = 0.02), weight (1.4 ± 0.3 kg; p = 0.03), prealbumin (3.5 ± 4.1 mg/dl; p = 0.01), albumin (1.3 ± 0.1 mg/dl; p = 0.03), and transferrin (71.5 ± 24.1 mg/dl; p = 0.02). Dietary intake of the ONS represented 14.4 % of the diet’s total caloric intake at 3 months, 17.5 % of carbohydrates, 12.9 % of proteins, and 12.3 % of fats. Mean compliance was 87.7 ± 7.2 % of the prescribed intakes. In relation to the nutritional situation, at the beginning of the study, 52.3 % (n = 23) of patients were in the global subjective assessment test in category B (moderate malnutrition or nutritional risk), and 47.7 % (n = 21) in category C (severe malnutrition). After the intervention, 75 % of patients were in category A (n = 33), 13.6 % (n = 6) in category B, and 11.4 % (n = 5) in category C. Conclusions: the use of a peptide-based ONS with short-chain triglycerides in outpatients showed a beneficial effect on biochemical and anthropometric parameters, and improved the nutritional status of patients with high compliance and good tolerance rates.
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- 2021
7. [Effect of a Mediterranean-pattern diet on the metabolic response secondary to weight loss; role of the single nucleotide polymorphism (rs16147) of neuropeptide Y]
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Juan José López Gómez, Esther Delgado, David Primo Martín, Daniel Antonio de Luis Román, Beatriz Torres Torres, Olatz Izaola Jáuregui, Emilia Gómez Hoyos, Ana Ortola Buigues, and Gonzalo Díaz
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Adult ,Male ,medicine.medical_specialty ,Mediterranean diet ,medicine.medical_treatment ,Medicine (miscellaneous) ,Single-nucleotide polymorphism ,Diet, Mediterranean ,Polymorphism, Single Nucleotide ,Insulin resistance ,Weight loss ,Internal medicine ,Weight Loss ,medicine ,Humans ,In patient ,Neuropeptide Y ,Obesity ,Nutrition and Dietetics ,business.industry ,Insulin ,Weight change ,Middle Aged ,medicine.disease ,Neuropeptide Y receptor ,Endocrinology ,Female ,medicine.symptom ,business - Abstract
espanolIntroduccion y objetivos: los estudios de intervencion que evaluan el efecto del rs16147 sobre la respuesta metabolica y el cambio de peso despues de una intervencion dietetica son escasos. Evaluamos el papel de la variante genetica rs16147 en los efectos metabolicos que produce una dieta hipocalorica de patron mediterraneo y alto contenido en omega-9. Material y metodos: se recluto una muestra de 363 sujetos obesos. En visita basal, los pacientes se asignaron aleatoriamente, durante 12 semanas, a recibir una de dos dietas: dieta M, de patron mediterraneo, o dieta C, hipocalorica estandar. Se determinaron momento basal y a las 12 semanas, una serie de variables bioquimicas y antropometricas, realizandose el genotipado de la variante rs16147. Resultados: en todos los sujetos con ambas dietas mejoraron los parametros de adiposidad, tension arterial y leptina circulante. En sujetos obesos con el alelo menor (A), los niveles de insulina (GG vs. GA + AA) (-0,9 ± 1,1 UI/L vs. -4,4 ± 1,0 UI/L; p = 0,01) y HOMA-IR (-0,3 ± 0,1 unidades vs. -1,2 ± 0,3 unidades; p = 0,02) disminuyeron significativamente con dieta M. Los sujetos portadores del alelo menor tras dieta C mostraron disminucion significativa de niveles de insulina basal (GG vs. GA + AA) (0,7 ± 0,3 UI/L vs. -2,2 ± 0,9 UI/L: p = 0,02) y HOMA-IR (-0,3 ± 0,2 unidades vs. -0,7 ± 0,1 unidades: p = 0,01). Esta disminucion de los niveles de insulina circulante y HOMA-IR en los pacientes con alelo A fue significativamente superior con la dieta M que con la dieta S. Conclusiones: el alelo A de la variante rs16147 se relaciona con mejor respuesta metabolica, en terminos de resistencia a insulina e insulina basal secundaria a perdida de peso, a dos dietas hipocaloricas, siendo superior el efecto obtenido con una dieta de patron mediterraneo. EnglishBackground and aims: intervention studies that evaluate the effect of rs16147 on metabolic response and weight change after dietary intervention are scarce. We propose to evaluate the role of the rs16147 genetic variant in the metabolic effects produced by a hypocaloric Mediterranean-pattern diet with high content of omega-9. Material and methods: a sample of 363 obese subjects was recruited. At the baseline visit the patients were randomly assigned to one of two hypocaloric diets for 12 weeks (diet M, Mediterranean pattern; diet C, standard hypocaloric). All patients, at baseline and at 12 weeks, had biochemical and anthropometric variables measured, and genotyping performed for the rs16147 variant. Results: in all subjects, and with both diets, the parameters of adiposity, blood pressure, and circulating leptin improved. In obese subjects with allele (A) insulin levels (GG vs. GA + AA) (-0.9 ± 1.1 IU/L vs. -4.4 ± 1.0 IU/L; p = 0.01) and HOMA-IR (-0.3 ± 0.1 units vs. -1.2 ± 0.3 units; p = 0.02) decreased significantly with diet M. Subjects carrying the minor allele showed a significant decrease in basal insulin levels (GG vs. GA + AA) (0.7 ± 0.3 IU/L vs. -2.2 ± 0.9 IU/L: p = 0.02) and HOMA-IR (-0.3 ± 0.2 units vs. -0.7 ± 0.1 units: p = 0.01) after diet C. This decrease in circulating insulin and HOMA-IR levels in patients with allele A was significantly higher with diet M than with diet C. Conclusions: the A allele of the rs16147 variant produces a better metabolic response in terms of insulin resistance and basal insulin secondary to weight loss with two different hypocaloric diets in obese subjects, with improvement being higher with the Mediterranean diet.
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- 2020
8. ACYL-CoA synthetase long-chain 5 polymorphism is associated with weight loss and metabolic changes in response to a partial meal-replacement hypocaloric diet
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David Primo Martín, Olatz Izaola Jáuregui, Ana Ortola Buigues, Esther Delgado, Juan José López Gómez, Emilia Gómez Hoyos, Daniel Antonio de Luis Román, and Beatriz Torres Torres
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Adult ,Male ,medicine.medical_specialty ,Weight loss ,Meal replacement ,Medicine (miscellaneous) ,ACSL5 ,Internal medicine ,rs2419621 ,Coenzyme A Ligases ,Weight Loss ,medicine ,Humans ,Obesity ,Hypocaloric diet ,Aged ,Caloric Restriction ,Acyl-CoA synthetase ,Polymorphism, Genetic ,Nutrition and Dietetics ,business.industry ,Middle Aged ,Endocrinology ,Female ,medicine.symptom ,business ,Long chain - Abstract
espanolAntecedentes: se hipotetiza que el genotipo de la acil-CoA-sintetasa 5 (ACSL5) podria influir en la perdida de peso secundaria a la restriccion de energia. Objetivos: el objetivo de nuestro estudio fue analizar los efectos de la variante genetica rs2419621 del gen ACSL5 sobre el cambio de peso y los parametros metabolicos despues de una dieta hipocalorica parcial de reemplazo. Metodos: estudio no aleatorizado, de centro unico, con una formula dietetica, en 44 sujetos obesos con un indice de masa corporal (IMC) superior a 35 kg/m2. Los pacientes recibieron educacion nutricional y una dieta modificada con dos tomas de una formula hiperproteica normocalorica durante 3 meses. Los parametros antropometricos y el perfil bioquimico se determinaron en el tiempo basal y tras 3 meses. La variante rs2419621 del gen ACSL5 se evaluo mediante reaccion en cadena de la polimerasa en tiempo real. Resultados: los portadores del alelo T mostraron mejorias de peso corporal (CC vs. CT + TT; -7,4 ± 2,1 kg vs. -9,3 ± 1,8 kg; p = 0,01), indice de masa corporal (-3,1 ± 0,4 kg/m2 vs. -3,4 ± 0,5 kg/m2; p = 0,02), masa grasa (-5,2 ± 1,4 kg vs. -6,4 ± 1,2 kg; p = 0,01) y circunferencia de la cintura (-6,1 ± 1,1 cm vs. -8,6 ± 0,8 cm; p = 0,02) superiores a las de los portadores de alelos distintos de T. Solo los sujetos con alelo T mostraron una mejoria significativa en los niveles de trigliceridos (-4,6 ± 2,4 md/dL vs. -14,4 ± 2,3 mg/dL; p = 0,01). Por ultimo, la mejoria de la insulina (-2,0 ± 0,3 mU/L vs. -4.5 ± 0.5 mU/L; p = 0,01) y HOMA-IR (-0,4 ± 0,2 unidades vs. -1,3 ± 0,3 unidades; p = 0,02) fueron mayores en los portadores de alelos T que en los portadores de alelos no T. Conclusiones: nuestros resultados sugieren que la variante genetica (rs2419621) del gen ACSL5 esta asociada a la respuesta a la dieta despues una dieta hipocalorica parcial de reemplazo, con una mejoria superior de los parametros relacionados con la adiposidad y los parametros bioquimicos en los sujetos con alelo T. EnglishAims:to analyze the effects of the rs2419621 genetic variant of the ACSL5 gene on weight change and metabolic parameters after a partial meal-replacement hypocaloric diet. Methods: this was a non-randomized, single-treatment study with a formula-diet in 44 obese subjects with body mass index (BMI) greater than 35 kg/m2. Patients received nutritional education and a modified diet with two intakes of a normocaloric hyperproteic formula during 3 months. Anthropometric parameters and biochemical profile were measured at baseline and after 3 months. The rs2419621 variant of the ACSL5 gene was assessed using real-time polymerase chain reaction. Results: T-allele carriers showed greater improvement in body weight (CC vs. CT + TT; -7.4 ± 2.1 kg vs. -9.3 ± 1.8 kg; p = 0.01), body mass index (-3.1 ± 0.4 kg/m2 vs. -3.4 ± 0.5 kg/m2; p = 0.02), fat mass (-5.2 ± 1.4 kg vs. -6.4 ± 1.2 kg; p = 0.01) and waist circumference (-6.1 ± 1.1 cm vs. -8.6 ± 0.8 cm; p = 0.02) than non-T-allele carriers. Only subjects with the T allele showed significant improvement in triglyceride levels (-4.6 ± 2.4 md/dL vs. -14.4 ± 2.3 mg/dL; p = 0.01). Finally, improvements in insulin (-2.0 ± 0.3 mU/L vs. -4.5 ± 0.5 mU/L; p = 0.01) and HOMA-IR (-0.4 ± 0.2 units vs. -1.3 ± 0.3 units; p = 0.02) were higher in T-allele carriers than in non-T-allele carriers. Conclusions: our data suggest that the genetic variant (rs2419621) of the ACSL5 gene is associated with diet response after a partial-meal replacement intervention, with greater improvements in adiposity and biochemical parameters in subjects with the T allele.
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- 2020
9. Acute lethargy, the main symptom of macroprolactinoma
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Juan José López Gómez, Luis Roman Daniel De, Rebeca Jiménez Sahagún, Susana García Calvo, Gonzalo Diaz Soto, Emilia Gómez Hoyos, Beatriz Torres Torres, Esther Delgado Garcia, Ana Ortola Buigues, and Cristina Serrano
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Lethargy ,Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,Macroprolactinoma ,business - Published
- 2019
10. Uncommon cause of dilated cardiomyopathy
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Ana Ortola Buigues, Rebeca Jiménez Sahagún, Cristina Serrano Valles, Susana García Calvo, Gonzalo Diaz Soto, Silvio H Vera Vera, Emilia Gómez Hoyos, Daniel Antonio de Luis Román, and Esther Delgado Garcia
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Dilated cardiomyopathy ,medicine.disease ,business - Published
- 2019
11. Hyponatremia-associated mortality and volemia in patients on parenteral nutrition: a prospective multicenter study
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María Dolores del Olmo García, Cristina Tejera Pérez, Irene Bretón Lesmes, Ana Herrero Ruiz, Sandra Herranz Antolin, Miguel Ángel Martínez Olmos, Julia Álvarez Hernández, Ana Ortola Buigues, Daniel Antonio de Luis Román, and Emilia Gómez Hoyos
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Pediatrics ,medicine.medical_specialty ,Parenteral nutrition ,Multicenter study ,business.industry ,medicine ,In patient ,Hyponatremia ,medicine.disease ,business - Published
- 2018
12. Hyponatremia in the emergency room of a general teaching hospital: room for improvement
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Martín Cuesta Hernández, Emlia Gomez Hoyos, José Ángel Díaz Pérez, Teresa Ruiz Gracia, Ana Ortola Buigues, Irene Crespo Hernandez, la Vega Isabelle Runkle de, Alfonso Luis Calle Pascual, Miguel Novoa Paz de, and Francisco Fernández Capel
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medicine.medical_specialty ,business.industry ,Emergency medicine ,medicine ,Medical emergency ,Hyponatremia ,medicine.disease ,business ,Teaching hospital - Published
- 2014
13. Treatment of SIADH in a patient with fatal familial insomnia (FFI) and hypersomnia
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Alfonso Luis Calle Pascual, Isabelle Runkle de la Vega, Alberto Marco Dolado, Irene Crespo Hernandez, Ana Ortola Buigues, Emilia Gómez Hoyos, David Garcia Azorin, Francisco Martinez Orozco, Martín Cuesta Hernández, and Teresa Ruiz Gracia
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Fatal familial insomnia ,Pediatrics ,medicine.medical_specialty ,business.industry ,medicine ,medicine.disease ,business - Published
- 2014
14. Cinacalcet hydrochloride more efficiently controls serum calcium levels in mild-asymptomatic primary hyperparathyroidism without surgery criteria, as compared with surgical cases
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Paz de Miguel Novoa, Alfonso Luis Calle Pascual, Maria Concepcion Sanabria Perez, Teresa Ruiz Gracia, Irene Crespo Hernandez, Martín Cuesta Hernández, Emilia Gómez Hoyos, Francisco Fernandez Capel, Isabelle Runkle de la Vega, and Ana Ortola Buigues
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medicine.medical_specialty ,chemistry ,Cinacalcet Hydrochloride ,business.industry ,medicine ,chemistry.chemical_element ,Calcium ,medicine.symptom ,medicine.disease ,business ,Asymptomatic ,Primary hyperparathyroidism ,Surgery - Published
- 2014
15. Unresectable Recurrent Multiple Meningioma: A Case Report with Radiological Response to Somatostatin Analogues
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Ana Ortolá Buigues, Irene Crespo Hernández, Manuela Jorquera Moya, and Jose Ángel Díaz Pérez
- Subjects
Somatostatin receptors ,Meningeal neoplasms ,Meningioma ,Octreotide ,Somatostatin ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed. In addition, these medications have been shown to have an antiproliferative and antiangiogenic effect in vitro. To date, very few cases with clinical response and none with radiological response have been described. The case described here is the first to report a radiological response. A 76-year-old Caucasian male was first diagnosed with unresectable meningioma at age 47. The patient experienced multiple recurrences and underwent three surgeries and radiotherapy over the years from the initial diagnosis. Despite treatment, the disease continued its progression. Based on an Octreoscan positive for tumour uptake, therapy with extended-release somatostatin analogues was started. Although no clinical neurological improvement was observed, magnetic resonance imaging scans revealed a discreet but continuous radiological response over time. After >2 years of continuous administration of lanreotide, the patient remains progression free. In highly selected cases, somatostatin analogue treatment for meningioma may be beneficial. Based on our findings, treatment with somatostatin analogues should be maintained longer than previously described before evaluating treatment response.
- Published
- 2016
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