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1. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate

Author

Bruno Caramelli, Claudia Y.S.M. de Bernoche, Ana M. C. Sartori, Andrei C. Sposito, Raul D. Santos, Maristela C. Monachini, Tania Strabelli, and Davi Uip

Subjects
Cholesterol, lipids, HIV infection, triglycerides, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p

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