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Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate
- Source :
- Brazilian Journal of Infectious Diseases, Vol 5, Iss 6, Pp 332-338
- Publisher :
- Elsevier.
-
Abstract
- Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p
Details
- Language :
- English
- ISSN :
- 16784391 and 14138670
- Volume :
- 5
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Brazilian Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6ed92e8bc6d14115a95dd22febe1233b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S1413-86702001000600007