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Este artículo explora las diversas estrategias de escenificación de la voz y presencia autoriales en los textos de la escritora peruana Gabriela Wiener quien ensaya distintas formas de autofiguración, nutriéndose de temáticas y formas codificadas de las escrituras del yo para luego ponerlas en cuestión. Con ese fin, me apoyo en las teorías de Erika Fischer-Lichte (2004) sobre la estética de lo performativo en el contexto de la deriva autorreflexiva y autorreferencial del arte posmoderno, así como en la noción de autoría performativa de Sonya Longolius (2016), para quien se hace necesario distinguir el yo autobiográfico del yo-autor cuyo nombre aparece en los libros y cuya identidad está en perpetua evolución. Las obras de Gabriela Wiener que aluden de forma explícita a la función autorial y que serán objeto de estudio son el cómic "Todos vuelven" (Llamada perdida, 2009), el libro de entrevistas "Dicen de mí" (2017), la obra dramática "Qué locura enamorarme yo de ti" (2019) y la novela "Huaco retrato" (2021). Sus estrategias performativas coinciden con las enumeradas por Longolius, ya que pasan por: 1) integrar otras voces en el propio texto; 2) proyectarse como figura de autor en la obra; y 3) difuminar las fronteras entre autobiografía y ficción. Añadiré una cuarta, consistente en repetir las prácticas reguladoras de lo que se entiende por autoría e introducir determinados elementos subversivos que la resignifican (Sayad 2013: 12).

Cancer and cancer therapies are a major factor risk for osteoporosis due to bone loss and deterioration of bone microarchitecture. Both factors contribute to a decrease in bone strength and, consequently, increased bone fragility and risk of fracture. Cancer-associated bone loss is a multifactorial process, and optimal interdisciplinary management of skeletal health, accurate assessment of bone density, and early diagnosis are essential when making decisions aimed at reducing bone loss and fracture risk in patients who have received or are receiving treatment for cancer. In this document, a multidisciplinary group of experts collected the latest evidence on the pathophysiology of osteoporosis and its prevention, diagnosis, and treatment with the support of the Spanish scientific society SEOM. The aim was to provide an up-to-date and in-depth view of osteoporotic risk and its consequences, and to present a series of recommendations aimed at optimizing the management of bone health in the context of cancer.

Introducción al dosier monográfico "Autoficción y discurso crítico: articulaciones del yo con lo real en la cultura hispánica contemporánea"

The Epi-GEICAM study comprises 1017 invasive BC cases matched with controls of similar age (49 +/- 9 years) and residence. Diet and OO consumption were collected through a validated food frequency questionnaire. 75% of women referred OO, common (refined) or virgin, as the main fat source. Using conditional logistic regression models, we compared different scenarios of type and frequency of OO consumption, using as reference those women not always using OO for the three culinary practices (seasoning, cooking, and frying) and adding = 2 tbsps. of OO per day during meals (adjusted OR, 0.72; 95% CI: 0.51, 1.03; P = 0.07). Potential benefits from OO consumption, at least as regards the protection provided for BC, could be mostly conferred with VOO, and when its consumption is high.

BACKGROUND: Metastatic breast cancer (mBC) remains an incurable disease and is the cause of nearly all deaths related to BC. Next-generation sequencing technologies are allowing the application of personalized targeted molecular therapies, thereby improving outcomes in breast cancer patients. However, they are not routinely used in the clinic and their cost could be a cause of disparity. One strategy to overcome the barriers of implementing NGS in the clinic is to promote the active participation of patients with mBC in the management of their disease and offering free access to these tests. With this in mind, we designed HOPE (SOLTI-1903), a Spanish real-world study where patients lead their inclusion, participation, and follow-up through a digital tool (DT) that guides them in every step of the journey. The ultimate objective of HOPE is to gather real-world data on the utilization of molecular information in the management of mBC and to empower these patients. TRIAL DESIGN: Patients diagnosed with locally advanced or mBC can be included. Basic demographic data, disease characteristics, treatment history and quality of life data are collected by patients through a DT. The study is complemented by a patient empowerment program including informative workshops and precision medicine video-tutorials. Patients are encouraged to involve their physicians in HOPE. A total of 600 patients will be included in Spain. PATIENT JOURNEY: Once patients request participation through the DT, a dedicated team in SOLTI assists them in the subsequent steps while validating that eligibility criteria are met according to patient-provided data. Then, patients receive instructions from SOLTI’s team to attend the nearest partner local laboratory, where they sign the study informed consent form. A metastatic (preferably) or primary archival tumor sample is requested from the patient’s reference hospital and analyzed by FoundationOne®CDx. Patients that are in progression or not receiving active systemic chemo- or radiotherapy undergo a blood draw to receive a Guardant360 analysis. These two NGS tests are offered to all patients, and the blood test is performed even if no tissue is available. The results from the molecular analyses are regularly reviewed by a Molecular Advisory Board (MAB). The MAB, based on its joint experience in clinical oncology, genomics, bioethics, and pathology, may add some advice to these reports via DT, making comments about detected molecular alterations and adding further recommendations for specific treatment options or available CT with targeted therapies and/or additional genetic tests such as germline validation of potentially significant findings. From that moment, patients are requested to record their disease evolution in the DT every 3 months for 2 years. The primary objective is to assess the real-world clinical practice integrating molecular profiling in the Standard of Care management of patients with mBC connected through a DT. Secondary objectives include to i) describe the genetic mutational profile of mBC, ii) estimate the enrollment rate in CT of patients engaged in a patient-centered strategy for molecular tumor assessment, iii) assessing Progression Free Survival, Overall Survival and Quality of Life status among patients enrolled in CT according to the tumor’s genomic profile and iv) evaluate the logistic feasibility of the study. Recruitment started on October 2020. By June 2021, 362 patients had been enrolled. ACKNOWLEDGEMENTS: This study is sponsored by SOLTI and financially supported by Novartis and three non-profit organizations: Asociación Cáncer de Mama Metastásico, Asociación Saray and Fundación Actitud frente al Cáncer. Roche and Guardant Health provide their tests for all patients. Citation Format: Ana Casas, Eva Ciruelos, Mafalda Oliveira, Cristina Saura, Meritxell Bellet, Sonia Pernas, Joaquín Gavilá, Montserrat Muñoz, Maria Vidal, Blanca González-Farré, Juan M. Cejalvo, Rafael López, Ana Vivancos, Marcos Malumbres, Javier Salvador Bofill, Isabel Blancas, Emilio Alba, Valentina Boni, Susana De la Cruz, Elena Galve, Antonia Perelló, Mireia Margelí, Meritxell Soler, Rubén Olivera-Salguero, Helena Masanas, Rosa Olmos, Marga Forns, Pilar Fernández Pascual, Elia Seguí, Tomas Pascual, Aleix Prat. Solti-1903 HOPE: Real-world clinical practice study to assess the impact of using genomic data on the next treatment decision making-choice in patients with locally advanced or metastatic breast cancer in Spain [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr OT2-06-01.

Nowadays, resveratrol, a polyphenolic phytoalexin is increasingly included in the formulas of cosmetic products and dermatology as an active ingredient, as a consequence of the well-known health beneficial properties, namely antioxidant, anti-inflammatory, anti-viral and anti-bacterial effects. This important compound can be biosynthesized naturally by plants or by industrial synthetic processes. Apart from its anti-inflammatory and antioxidant effects, a broad spectrum of effects has been attributed to the use of this compound such as anti-aging, skin-whitening, anti-angiogenic, collagen I and III stimulation (in fibroblasts) and estrogen-like effects, as well as the ability to protect cells against hydrogen peroxide-induced oxidative stress and UV-irradiation-mediated cell death. In cosmetology and dermatology has been popular because of its ability to penetrate the skin barrier and its anti-aging activity. In fact, resveratrol as an important impact on the regulation of inflammation and, as consequence, repair-related processes in skin. Furthermore, when administered either topically or orally has been proven to be safe and also to overcome the skin barrier. This review will focus in its potential application on melasma treatment and in photo-aging. Resveratrol chemistry, pharmacology, mechanism of action and evidence of its efficacy as photo skin aging protector and its potential use in melasma is discussed.

Aim: To understand breast cancer patients' trade-offs when choosing treatments and to identify the most important treatment attributes which drive decisions. Materials & methods: A discrete choice experiment was conducted in France, Ireland, Poland and Spain. Progression-free survival, febrile neutropenia, pain, functional well-being and out-of-pocket payment were the treatment attributes. Results: 371 patients were willing to pay €6896 per year for 1 additional year of progression-free survival, €17,288 per year for perfect functional well-being and €15,138 for one pain-free year. Patients are willing to trade off progression-free survival months for better functional abilities and less pain. Conclusion: Patient preferences should be considered by regulatory agencies, reimbursement bodies, payors and clinicians for best treatment choices for the individuals.

Health-related quality of life (HRQOL) is increasingly recognized as important when evaluating cancer treatments. The use, reporting, and analysis of patient-reported outcome measures (PROMs), however, are not standardized in clinical trials and are often poorly implemented in clinical practice. We report the results of a systematic literature review (PubMed search: January 1, 2000 to August 15, 2020) of PROM use, reporting, and analysis in phase 3 clinical trials of hormone receptor–positive (HR+) advanced breast cancer (ABC). Further inspection of cyclin-dependent kinase 4/6 (CDK4/6) inhibitor publications was performed to examine PROMs in the HR+/human epidermal growth factor receptor 2–negative (HER2-) setting. A total of 88 results were identified in the initial search; 32 were included in the final analysis. Among included studies, most (66%) had been published in the last 5 years (2015 to 2020). CDK4/6 inhibitors (38%) were the most common agents reported. No clear standard for PROM use, reporting, or analysis was found. The most common PROMs were European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) (59%) and the Functional Assessment of Cancer Therapy–Breast (FACT-B; 34%). Important differences, among studies that reported them, ranged from 5 to 10 points for the EORTC QLQ-C30 and 8 points for the FACT-B total score. This review showed that a lack of clear consistency remains for PROM use, reporting, and analysis in phase 3 clinical trials of HR+ ABC. However, HRQOL is of high interest in the literature, including for CDK4/6 inhibitors.

Formation of surficial sulfate– and halide–bearing salts by syn–eruptive ash–gas interactions is known to occur during volcanic eruptions. For reactions between aluminosilicates and the gas SO2, at...

Le present article analyse plusieurs romans contemporains dans lesquels les representations textuelles de leurs auteurs meurent effectivement dans le monde de la fiction. Leur disparition en tant que personnages monopolise le discours parodique qui vise a subvertir certains codes que le lecteur connait bien, concretement le rapport entre auteur et œuvre et les liens de cette derniere avec le referent.

In 1967, García Pavón publishes the volume of short stories La guerra de los dos mil años, in which he moves away from the realism that characterize all his previous (and later) production. In this book, Garcia Pavón chooses the fantastic, the dystopia and the grotesque as a means to denounce the Spanish reality of the moment and the recent past –especially the Civil War–. The objective of this article is to analyze the main formal and thematic resources of this book, as well as its contextualization and its clear intention of social and political criticism of the endemic problems of Spanish society and, above all, the abuses of the Franco dictatorship. These aspects have been barely mentioned or altogether ignored in the few studies devoted to La guerra de los dos mil años. This will allow not only to broaden the interpretations of García Pavón’s book held up to now, but also to show his dissident stance regarding the Franco regime manifested through various non-mimetic means of expression. En 1967, García Pavón publica el volumen de cuentos La guerra de los dos mil años, en el que se aleja del realismo que caracteriza toda su producción anterior (y posterior) y se interna por los caminos de lo fantástico, la ciencia ficción y lo grotesco con una clara voluntad de denuncia de la realidad española del momento y del pasado reciente –en especial, la Guerra Civil–. El objetivo de este artículo es analizar los principales recursos formales y temáticos de esta obra, así como su contextualización y su clara intención de crítica social y política de los males endémicos de la sociedad española y, sobre todo, de los abusos de la dictadura franquista, aspectos que los escasos trabajos dedicados a La guerra de los dos mil años no habían estudiado o apenas habían destacado. Ello permitirá no solo ampliar las interpretaciones del libro de García Pavón hasta ahora sostenidas, sino evidenciar su postura disidente respecto al régimen de Franco manifestada a través de diversas vías de expresión no miméticas.

En la época de crisis de los grandes relatos, la literatura sigue reclamando la reconexión con el contexto y la intervención en lo social. Desde esta óptica, la autoficción puede entenderse como un medio a través del que expresar la autoconciencia artística, al mismo tiempo que confía en lo literario como una manera de conocer el mundo y de ofrecer explicaciones –aunque personales y subjetivas– a los diversos procesos sociales y políticos que nos afectan. Partiendo de esta hipótesis, el presente artículo tiene como fin abordar esta dimensión crítica de la autoficción, conectándola con el llamado giro subjetivo, que afecta a buena parte de las producciones actuales y conduce a basar la transmisión del conocimiento histórico y la comprensión de lo social en una experiencia del individuo. Con ese objetivo, se abordarán los cruces e interferencias entre los discursos políticos y literarios a partir del análisis de Honrarás a tu padre y a tu madre (2018), la reciente novela de Cristina Fallarás, teniendo en cuenta la transnacionalización de determinados conceptos del ámbito de la represión y la violencia que originariamente provienen de otros contextos distintos del español. De este modo, nos interrogaremos sobre la pertinencia de los apelativos “narrativa de la posmemoria”, “literatura de los nietos” o “detenido-desaparecido” (que el sociólogo Gatti aplica al contexto argentino, pero que es posible extrapolar al caso español), como nociones susceptibles de explicar determinadas manifestaciones artísticas, como la que aquí nos ocupa.

Entrevista a Cristina Fernández Cubas (Arenys de Mar, Barcelona, 1945) por Ana Casas.

Encouraging students to justify earlier as they attempt to solve an open-ended task can lead to greater understanding and engagement.

Many ABC/MBC (advanced or metastatic breast cancer) patients describe feelings of isolation and lack of support [1], often exacerbated by inadequate and insensitive communication. To examine these issues and the changing landscape of the wider breast cancer (BC) community, eight BC patients from across Europe took part in an advisory board. Each patient generously gave up their time to discuss how communication could be enhanced; driven by a desire to improve the experience and bolster support for future ABC/MBC patients. The most powerful and touching message emerged; maintaining the feeling of hope was vitally important as was the knowledge they were not alone in their diagnosis, with patient-to-patient communication representing an important ‘lifeline’. It transpired that patients found certain language difficult, confusing and shocking to deal with, particularly as their disease journey was very much an emotional rather than clinical one. For those communicating with ABC/MBC patients, adopting an empathic, patient and personalized language and approach was considered invaluable. Here we examine further the key findings of the advisory board to help shape how, step-by-step, we can change the language we use in practice to effectively and sensitively communicate with ABC/MBC patients., Graphical abstract Abstract Fig. 1: The Dos and Don’ts of Communicating with ABC/MBC patients, a quick guide. Many HCPs will automatically already follow the tips and avoid the pitfalls outlined below, so this guide is intended only as a reminder.Image 1

In this work, the dissolution of pine and eucalyptus woods in the ionic liquid 1-allyl-3-methylimidazolium chloride (AmimCl) under microwave radiation and the regeneration of their main compounds from the wood solutions were studied. The influence of temperature, time, and the presence or not of wood extractives in both the dissolution and the regenerated solids was evaluated. The regenerated products from solutions of both wood species in the AmimCl were identified by Fourier transform infrared spectroscopy and compared to reference materials (Indulin AT lignin and microcrystalline cellulose). High temperatures, long dissolution times, and extractive-free wood promoted the pine and eucalyptus dissolution in the AmimCl. Cellulose was successfully regenerated from pine and eucalyptus woods solutions at low temperatures and times, whereas lignin was regenerated when the experimental conditions were more severe. In addition, the previous wood extraction decreased the lignin content in regenerated solids.

Extraction of toluene from heptane at T = 313.2 K and atmospheric pressure using a mixed solvent composed of the ionic liquids 1-butyl-4-methylpyridinium bis(trifluoromethylsulfonyl)imide ([4bmpy][Tf 2 N]) and 1-ethyl-3-methylimidazolium 1,1,2,2-tetrafluoroethanesulfonate ([emim][CHF 2 CF 2 SO 3 ]) has been considered in this study. The results show that for a mole fraction of 0.3 for [4bmpy][Tf 2 N] the values of the capacity of extraction of toluene and the selectivity of the mixed solvent are higher than those of sulfolane for the whole range of compositions, taken this organic solvent as a benchmark. Therefore, this mixture of ILs could be an alternative to sulfolane in the liquid–liquid extraction of toluene from heptane.

Lignin is a renewable bioresource with a variety of applications. The development of green processes for wood dissolution and lignin regeneration would be really useful in the context of biorefinery and biomass efficient employment. Ionic liquids offer an interesting alternative in this regard. In this paper, regeneration of lignin from Pinus radiata and Eucalyptus globulus woods dissolved in imidazolium-based ionic liquids was studied. Microwave radiation was employed as thermal source in order to decrease the wood dissolution time. Several ionic liquids were used for wood dissolution: 1-butyl-3-methylimidazolium acetate (BmimAc), 1-ethyl-3-methylimidazolium acetate (EmimAc), 1-ethyl-3-methylimidazolium chloride (EmimCl), 1-butyl-3-methylimidazolium chloride (BmimCl) and 1-allyl-3-methylimidazolium chloride (AmimCl). All the ionic liquids were able to dissolve wood. Furthermore, lignin was successfully regenerated by precipitation with an antisolvent from solutions of wood in AmimCl, BmimCl or EmimCl. Regenerated lignin, characterized by Fourier transform infrared spectroscopy, 13 C nuclear magnetic resonance, elemental analysis, thermogravimetric analysis, and differential scanning calorimetry, was compared to Indulin AT lignin, and showed different properties depending on the ionic liquid employed and the wood species.

The feasibility of the binary mixture of 1-butyl-4-methylpyridinium bis(trifluoromethylsulfonyl)imide and 1-ethyl-3-methylimidazolium ethylsulfate ({[4bmpy][Tf2N] + [emim][C2H5SO4]}) ionic liquids (ILs)) in the liquid–liquid extraction of toluene from heptane has been investigated at 313.2 K and atmospheric pressure. Toluene and heptane distribution ratios and toluene selectivity were obtained from the liquid–liquid equilibrium data for the pseudoternary system {heptane + toluene + ([4bmpy][Tf2N] + [emim][C2H5SO4])} and compared to those of sulfolane, the conventional organic solvent used in industry. Our results have revealed that an equimolar binary mixture of these ILs could be an environmentally friendly alternative to sulfolane.