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2. Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

Author

Verbitskiy, E. V., Baskakova, S. A., Rasputin, N. A., Gerasimova, N. A., Amineva, P. G., Evstigneeva, N. P., Zil'berberg, N. V., Kungurov, N. V., Kravchenko, M. A., Skornyakov, S. N., Rusinov, G. L., Chupakhin, O. N., Charushin, V. N., Verbitskiy, E. V., Baskakova, S. A., Rasputin, N. A., Gerasimova, N. A., Amineva, P. G., Evstigneeva, N. P., Zil'berberg, N. V., Kungurov, N. V., Kravchenko, M. A., Skornyakov, S. N., Rusinov, G. L., Chupakhin, O. N., and Charushin, V. N.

Abstract

A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc.

Published
2016

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