Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

Authors :: Verbitskiy, E. V.
Baskakova, S. A.
Rasputin, N. A.
Gerasimova, N. A.
Amineva, P. G.
Evstigneeva, N. P.
Zil'berberg, N. V.
Kungurov, N. V.
Kravchenko, M. A.
Skornyakov, S. N.
Rusinov, G. L.
Chupakhin, O. N.
Charushin, V. N.
Verbitskiy, E. V.
Baskakova, S. A.
Rasputin, N. A.
Gerasimova, N. A.
Amineva, P. G.
Evstigneeva, N. P.
Zil'berberg, N. V.
Kungurov, N. V.
Kravchenko, M. A.
Skornyakov, S. N.
Rusinov, G. L.
Chupakhin, O. N.
Charushin, V. N.
Source :: Arkivoc
Publication Year :: 2016
Abstract: A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc.

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