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6 results on '"Amalia Barreto-Luis"'

1. Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Author

Johannes, Waage, Marie, Standl, John A, Curtin, Leon E, Jessen, Jonathan, Thorsen, Chao, Tian, Nathan, Schoettler, Carlos, Flores, Abdel, Abdellaoui, Tarunveer S, Ahluwalia, Alexessander C, Alves, Andre F S, Amaral, Josep M, Antó, Andreas, Arnold, Amalia, Barreto-Luis, Hansjörg, Baurecht, Catharina E M, van Beijsterveldt, Eugene R, Bleecker, Sílvia, Bonàs-Guarch, Dorret I, Boomsma, Susanne, Brix, Supinda, Bunyavanich, Esteban G, Burchard, Zhanghua, Chen, Ivan, Curjuric, Adnan, Custovic, Herman T, den Dekker, Shyamali C, Dharmage, Julia, Dmitrieva, Liesbeth, Duijts, Markus J, Ege, W James, Gauderman, Michel, Georges, Christian, Gieger, Frank, Gilliland, Raquel, Granell, Hongsheng, Gui, Torben, Hansen, Joachim, Heinrich, John, Henderson, Natalia, Hernandez-Pacheco, Patrick, Holt, Medea, Imboden, Vincent W V, Jaddoe, Marjo-Riitta, Jarvelin, Deborah L, Jarvis, Kamilla K, Jensen, Ingileif, Jónsdóttir, Michael, Kabesch, Jaakko, Kaprio, Ashish, Kumar, Young-Ae, Lee, Albert M, Levin, Xingnan, Li, Fabian, Lorenzo-Diaz, Erik, Melén, Josep M, Mercader, Deborah A, Meyers, Rachel, Myers, Dan L, Nicolae, Ellen A, Nohr, Teemu, Palviainen, Lavinia, Paternoster, Craig E, Pennell, Göran, Pershagen, Maria, Pino-Yanes, Nicole M, Probst-Hensch, Franz, Rüschendorf, Angela, Simpson, Kari, Stefansson, Jordi, Sunyer, Gardar, Sveinbjornsson, Elisabeth, Thiering, Philip J, Thompson, Maties, Torrent, David, Torrents, Joyce Y, Tung, Carol A, Wang, Stephan, Weidinger, Scott, Weiss, Gonneke, Willemsen, L Keoki, Williams, Carole, Ober, David A, Hinds, Manuel A, Ferreira, Hans, Bisgaard, David P, Strachan, and Klaus, Bønnelykke

Subjects
0301 basic medicine, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Genome-wide association study, Human leukocyte antigen, Computational biology, Biology, Genetic pathways, Numbering, Article, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Genetics, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

In the version of this article initially published, in Fig. 3, the y-axis numbering did not match the log scale indicated in the axis label. The error has been corrected in the HTML and PDF version of the article.

Published
2018

2. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Author

Eugene R. Bleecker, Carlos Flores, Gonneke Willemsen, Kamilla Kjærgaard Jensen, Herman T. den Dekker, Zhanghua Chen, W. James Gauderman, Xingnan Li, Teemu Palviainen, Christian Gieger, Franz Rüschendorf, Dan L. Nicolae, Leon Eyrich Jessen, Hans Bisgaard, Nicole Probst-Hensch, Medea Imboden, Raquel Granell, Ingileif Jonsdottir, Maria Pino-Yanes, Supinda Bunyavanich, Manuel A. R. Ferreira, Michel Georges, Vincent W. V. Jaddoe, Stephan Weidinger, Hongsheng Gui, Esteban G. Burchard, Abdel Abdellaoui, Ivan Curjuric, Johannes Waage, Torben Hansen, Deborah A. Meyers, Rachel A. Myers, Lavinia Paternoster, Ashok Kumar, Ellen A. Nohr, Kari Stefansson, L. Keoki Williams, Andreas Arnold, David P. Strachan, David Torrents, Carol A. Wang, Dorret I. Boomsma, Julia Dmitrieva, Markus J. Ege, Joyce Y. Tung, Jordi Sunyer, Elisabeth Thiering, Nathan Schoettler, Deborah Jarvis, Sílvia Bonàs-Guarch, Joachim Heinrich, Shyamali C. Dharmage, Jaakko Kaprio, Craig E. Pennell, Marie Standl, Philip J. Thompson, Patrick G. Holt, Natalia Hernandez-Pacheco, Angela Simpson, Michael Kabesch, Josep M. Mercader, Marjo-Riitta Järvelin, Andre F.S. Amaral, Tarunveer S. Ahluwalia, Fabián Lorenzo-Díaz, John A. Curtin, Gardar Sveinbjornsson, Susanne Brix, Scott T. Weiss, Chao Tian, Adnan Custovic, David A. Hinds, Amalia Barreto-Luis, John Henderson, Hansjörg Baurecht, Young-Ae Lee, Catharina E. M. van Beijsterveldt, Jonathan Thorsen, Carole Ober, Alexessander Couto Alves, Frank D. Gilliland, Albert M. Levin, Josep M. Antó, Liesbeth Duijts, Erik Melén, Maties Torrent, Klaus Bønnelykke, Göran Pershagen, Epidemiology, Erasmus MC other, Pediatrics, Biological Psychology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and APH - Health Behaviors & Chronic Diseases

Subjects
0301 basic medicine, Netherlands Twin Register (NTR), HAY-FEVER, Allergy, Genome-wide association study, VARIANTS, Allergic sensitization, 0302 clinical medicine, HLA Antigens, 11 Medical and Health Sciences, Genetics & Heredity, CELL DEVELOPMENT, HERITABILITY, 3. Good health, Phenotype, DISEASES, Hay fever, Life Sciences & Biomedicine, EXPRESSION, Risk, Single-nucleotide polymorphism, Human leukocyte antigen, Biology, DENDRITIC CELLS, 23andMe Research Team, 03 medical and health sciences, Nonallergic rhinitis, SDG 3 - Good Health and Well-being, Genetics, medicine, Humans, Genetic Predisposition to Disease, METAANALYSIS, Science & Technology, RECEPTOR, Genome, Human, AAGC collaborators, Genetic Variation, Allergens, 06 Biological Sciences, medicine.disease, Rhinitis, Allergic, Genetic architecture, 030104 developmental biology, Genetic Loci, Case-Control Studies, Immunology, ASTHMA, 030217 neurology & neurosurgery, Genome-Wide Association Study, Developmental Biology
Abstract

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis. An Author Correction to this article was published on 16 August 2018. https://www.nature.com/articles/s41588-018-0197-6

Published
2018

3. Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene

Author

Carlos Flores, Ariel Callero, Almudena Corrales, Marialbert Acosta-Herrera, Maria Pino-Yanes, Jesús Villar, Amalia Barreto-Luis, Shwu Fan Ma, Joe G.N. Garcia, Angel Carracedo, Juan Antonio Martinez-Tadeo, Paloma Campo, Teresa Carrillo, Miguel Blanca, and José Cumplido

Subjects
0301 basic medicine, Genetics, Thrombospondin, Metallopeptidase, Immunology, ADAMTS9 Protein, Genome-wide association study, Susceptibility gene, Biology, Polymorphism, Single Nucleotide, ADAM Proteins, Asthma, White People, 03 medical and health sciences, 030104 developmental biology, Spain, Case-Control Studies, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Motif (music), Genetic Association Studies, Genome-Wide Association Study
Published
2016

4. A pathway-based association study reveals variants from Wnt signalling genes contributing to asthma susceptibility

Author

José Cumplido, Almudena Corrales, Maria Pino-Yanes, M. Acosta-Herrera, Teresa Carrillo, Angel Carracedo, Juan Antonio Martinez-Tadeo, Carlos Flores, Jesús Villar, C. Gonzalez-Colino, and Amalia Barreto-Luis

Subjects
0301 basic medicine, Adult, Male, Frizzled, Candidate gene, Immunology, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Genetic predisposition, Immunology and Allergy, Humans, Genetic Predisposition to Disease, Wnt Signaling Pathway, Genetic association, Genetics, Middle Aged, Asthma, 030104 developmental biology, 030228 respiratory system, Expression quantitative trait loci, Female, Genome-Wide Association Study
Abstract

Background: Genetic susceptibility to asthma is currently linked to a handful of genes which have a limited ability to predict the overall disease risk, suggesting the existence of many other genes involved in disease development. Accumulated evidence from association studies in genes related by biological pathways could reveal novel asthma genes. Objective: To reveal novel asthma susceptibility genes by means of a pathway-based association study. Methods: Based on summary data from a previous a genomewide association study (GWAS) of asthma, we first identified significant biological pathways using a gene-set enrichment analysis. We then mapped all tested single nucleotide polymorphisms (SNPs) on the genes contributing to significant pathways and prioritized those with a disproportionate number of nominal significant associations for further studies. For those prioritized genes, association studies were performed for selected SNPs in independent case–control samples (n = 1765) using logistic regression models, and results were meta-analysed with those from the GWAS. Results: Two biological processes were significantly enriched: the cytokine–cytokine receptor interaction (P = 0.002) and the Wnt signalling (P = 0.012). From the 417 genes interacting in these two pathways, 10 showed an excess of nominal associations, including a known asthma susceptibility locus (encoding SMAD family member 3) and other novel candidate genes. From the latter, association studies of 14 selected SNPs evidenced replication in a locus near the frizzled class receptor 6 (FZD6) gene (P = 9.90 × 10−4), which had a consistent direction of effects with the GWAS findings (meta-analysed odds ratio = 1.49; P = 5.87 × 10−6) and was in high linkage disequilibrium with expression quantitative trait loci in lung tissues. Conclusions and Clinical Relevance: This study revealed the importance of two biological pathways in asthma pathogenesis and identified a novel susceptibility locus near Wnt signalling genes.

Published
2016

5. HLA-DRB1*15:01 allele protects from asthma susceptibility

Author

Carlos Flores, José Carlos García-Robaina, Teresa Carrillo, Maria Pino-Yanes, Eva Perez-Rodriguez, Florentino Sánchez-García, Almudena Corrales, Inmaculada Sánchez-Machín, Amalia Barreto-Luis, Marialbert Acosta-Herrera, Angel Carracedo, Miguel Blanca, Inés Quintela, Paloma Campo, José Cumplido, Jesús Villar, and Tobias Felipe

Subjects
Male, Immunology, Biology, medicine.disease, Polymorphism, Single Nucleotide, Asthma, medicine, Immunology and Allergy, Humans, Female, Genetic Predisposition to Disease, Allele, HLA-DRB1, Alleles, HLA-DRB1 Chains
Published
2013

6. Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

Author

Carlos Flores, Celeste Eng, José Cumplido, Jesús Villar, Teresa Carrillo, Almudena Corrales, Marialbert Acosta-Herrera, Paloma Campo, Dara G. Torgerson, Eva Perez-Rodriguez, Inés Quintela, Maria Pino-Yanes, Amalia Barreto-Luis, Joe G.N. Garcia, José Carlos García-Robaina, Esteban G. Burchard, Miguel Blanca, Angel Carracedo, and Shwu Fan Ma

Subjects
Genetics, Myosin light-chain kinase, Association (object-oriented programming), Immunology, medicine, Immunology and Allergy, MYLK, Biology, medicine.disease, Gene, Molecular biology, Asthma
Published
2015

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