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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
- Source :
- The 23andMe Research Team & AAGC collaborators 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072–1080 . https://doi.org/10.1038/s41588-018-0157-1, Abdellaoui, A, van Beijsterveldt, C E M, Boomsma, D I, Willemsen, G & 23Andme Research Team 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072-1080 . https://doi.org/10.1038/s41588-018-0157-1, Curtin, J, Simpson, A, Custovic, A & et al. 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50 . https://doi.org/10.1038/s41588-018-0157-1, Nature Genetics, Nat. Genet. 50, 1072–1080 (2018), Nature Genetics, 50(8), 1072-+. Nature Publishing Group, Waage, J, Standl, M, Curtin, J A, Jessen, L E, Thorsen, J, Tian, C, Schoettler, N, the 23 and Me Research Team 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072-1080 . https://doi.org/10.1038/s41588-018-0157-1, Waage, J, Standl, M, Curtin, J A, Jessen, L E, Thorsen, J, Tian, C, Schoettler, N, Flores, C, Abdellaoui, A, Ahluwalia, T S, Alves, A C, Amaral, A F S, Antó, J M, Arnold, A, Barreto-Luis, A, Baurecht, H, van Beijsterveldt, C E M, Bleecker, E R, Bonàs-Guarch, S, Boomsma, D I, Brix, S, Bunyavanich, S, Burchard, E G, Chen, Z, Curjuric, I, Custovic, A, Den Dekker, H T, Dharmage, S C, Dmitrieva, J, Duijts, L, Ege, M J, Gauderman, W J, Georges, M, Gieger, C, Gilliland, F, Granell, R, Gui, H, Hansen, T, Heinrich, J, Henderson, J, Hernandez-Pacheco, N, Holt, P, Imboden, M, Jaddoe, V W V, Jarvelin, M R, Jarvis, D L, Jensen, K K, Jónsdóttir, I, Kabesch, M, Kaprio, J, The 23andMe Research Team & AAGC collaborators 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072-1080 . https://doi.org/10.1038/s41588-018-0157-1, Nature Genetics, 50(8), 1072-1080. Nature Publishing Group
- Publication Year :
- 2018
-
Abstract
- Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis. An Author Correction to this article was published on 16 August 2018. https://www.nature.com/articles/s41588-018-0197-6
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
HAY-FEVER
Allergy
Genome-wide association study
VARIANTS
Allergic sensitization
0302 clinical medicine
HLA Antigens
11 Medical and Health Sciences
Genetics & Heredity
CELL DEVELOPMENT
HERITABILITY
3. Good health
Phenotype
DISEASES
Hay fever
Life Sciences & Biomedicine
EXPRESSION
Risk
Single-nucleotide polymorphism
Human leukocyte antigen
Biology
DENDRITIC CELLS
23andMe Research Team
03 medical and health sciences
Nonallergic rhinitis
SDG 3 - Good Health and Well-being
Genetics
medicine
Humans
Genetic Predisposition to Disease
METAANALYSIS
Science & Technology
RECEPTOR
Genome, Human
AAGC collaborators
Genetic Variation
Allergens
06 Biological Sciences
medicine.disease
Rhinitis, Allergic
Genetic architecture
030104 developmental biology
Genetic Loci
Case-Control Studies
Immunology
ASTHMA
030217 neurology & neurosurgery
Genome-Wide Association Study
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- The 23andMe Research Team & AAGC collaborators 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072–1080 . https://doi.org/10.1038/s41588-018-0157-1, Abdellaoui, A, van Beijsterveldt, C E M, Boomsma, D I, Willemsen, G & 23Andme Research Team 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072-1080 . https://doi.org/10.1038/s41588-018-0157-1, Curtin, J, Simpson, A, Custovic, A & et al. 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50 . https://doi.org/10.1038/s41588-018-0157-1, Nature Genetics, Nat. Genet. 50, 1072–1080 (2018), Nature Genetics, 50(8), 1072-+. Nature Publishing Group, Waage, J, Standl, M, Curtin, J A, Jessen, L E, Thorsen, J, Tian, C, Schoettler, N, the 23 and Me Research Team 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072-1080 . https://doi.org/10.1038/s41588-018-0157-1, Waage, J, Standl, M, Curtin, J A, Jessen, L E, Thorsen, J, Tian, C, Schoettler, N, Flores, C, Abdellaoui, A, Ahluwalia, T S, Alves, A C, Amaral, A F S, Antó, J M, Arnold, A, Barreto-Luis, A, Baurecht, H, van Beijsterveldt, C E M, Bleecker, E R, Bonàs-Guarch, S, Boomsma, D I, Brix, S, Bunyavanich, S, Burchard, E G, Chen, Z, Curjuric, I, Custovic, A, Den Dekker, H T, Dharmage, S C, Dmitrieva, J, Duijts, L, Ege, M J, Gauderman, W J, Georges, M, Gieger, C, Gilliland, F, Granell, R, Gui, H, Hansen, T, Heinrich, J, Henderson, J, Hernandez-Pacheco, N, Holt, P, Imboden, M, Jaddoe, V W V, Jarvelin, M R, Jarvis, D L, Jensen, K K, Jónsdóttir, I, Kabesch, M, Kaprio, J, The 23andMe Research Team & AAGC collaborators 2018, ' Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis ', Nature Genetics, vol. 50, no. 8, pp. 1072-1080 . https://doi.org/10.1038/s41588-018-0157-1, Nature Genetics, 50(8), 1072-1080. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....84db3d9851e1a4d9d691683c498020d1