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3 results on '"Amélia Yi Viana"'

1. Donated chemical probes for open science

Author

Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, and Anke Mueller-Fahrnow

Subjects
Chemical probes, Target validation, Open Science, Medicine, Science, Biology (General), QH301-705.5
Abstract

Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.

Published
2018
Full Text
View/download PDF

2. Author response: Donated chemical probes for open science

Author

David H. Drewry, Steve Hitchcock, Volker Dötsch, Ingo Hartung, Brian D. Marsden, Hisanori Matsui, C. Bountra, Carrow I. Wells, Marcus Bauser, Stefan Knapp, Volkhart Mj Li, Amélia Yi Viana, Christian Fischer, Mathias John Paul, Adrian Carter, Spiros Liras, Julian Blagg, Mark Edward Bunnage, Suzanne Ackloo, Adriaan P. IJzerman, Susanne Müller, Stephen V. Frye, Saul H Rosenberg, Natalie S Schneider, Daniel K Treiber, Andreas Gollner, David R. Damerell, Cora Scholten, Bryan L. Roth, Cheryl H. Arrowsmith, Charles E. Grimshaw, Aled M. Edwards, Kumar Singh Saikatendu, Timothy M. Willson, Jeremy L Baryza, Thomas Hanke, Masayuki Takizawa, Peter Brown, Terry V Hughes, James P. Edwards, Daniel Rauh, Trevor Howe, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Chris Tse, Vineet Pande, Anton Simeonov, Paul R. Thompson, Dafydd R. Owen, J.M. Elkins, Jark Böttcher, William J. Zuercher, and Stefan Laufer

Subjects
Engineering, Open science, business.industry, Library science, business
Published
2018

3. Donated chemical probes for open science

Author

Julian Blagg, David H. Drewry, Steve Hitchcock, Hisanori Matsui, Carrow I. Wells, Daniel Rauh, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Adriaan P. IJzerman, Kumar Singh Saikatendu, Stefan Laufer, Timothy M. Willson, Paul R. Thompson, Chris Tse, Saul H Rosenberg, C. Bountra, Marcus Bauser, Dafydd R. Owen, Brian D. Marsden, Terry V Hughes, Daniel K Treiber, James P. Edwards, Bryan L. Roth, Cheryl H. Arrowsmith, Suzanne Ackloo, J.M. Elkins, Adrian Carter, Spiros Liras, Stefan Knapp, Christian Fischer, Susanne Müller, Amélia Yi Viana, Mathias John Paul, William J. Zuercher, Masayuki Takizawa, Jeremy L Baryza, Thomas Hanke, Peter Brown, David R. Damerell, Cora Scholten, Stephen V. Frye, Anton Simeonov, Mark Edward Bunnage, Charles E. Grimshaw, Andreas Gollner, Aled M. Edwards, Natalie S Schneider, Trevor Howe, Volker Dötsch, Ingo Hartung, Jark Böttcher, Vineet Pande, and Volkhart Mj Li

Subjects
0301 basic medicine, Open science, Computer science, QH301-705.5, Chemical probes, Science, General Biochemistry, Genetics and Molecular Biology, Target validation, 03 medical and health sciences, Science Forum, Open Science, Biochemistry and Chemical Biology, Technology, Pharmaceutical, Biology (General), Pharmaceutical industry, Pharmacology, Protein function, General Immunology and Microbiology, business.industry, General Neuroscience, Feature Article, Proteins, General Medicine, Data science, 3. Good health, 030104 developmental biology, Molecular Probes, Medicine, business
Abstract

Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de"https://openscienceprobes.sgc-frankfurt.de/ext-linkext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/"//ext-link). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.

Published
2018
Full Text
View/download PDF

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