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Donated chemical probes for open science
- Source :
- eLife, Vol 7 (2018), eLife, ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
- Publication Year :
- 2018
- Publisher :
- eLife Sciences Publications Ltd, 2018.
-
Abstract
- Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (ext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de"https://openscienceprobes.sgc-frankfurt.de/ext-linkext-link ext-link-type="uri" xlink:href="https://openscienceprobes.sgc-frankfurt.de/"//ext-link). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project.
- Subjects :
- 0301 basic medicine
Open science
Computer science
QH301-705.5
Chemical probes
Science
General Biochemistry, Genetics and Molecular Biology
Target validation
03 medical and health sciences
Science Forum
Open Science
Biochemistry and Chemical Biology
Technology, Pharmaceutical
Biology (General)
Pharmaceutical industry
Pharmacology
Protein function
General Immunology and Microbiology
business.industry
General Neuroscience
Feature Article
Proteins
General Medicine
Data science
3. Good health
030104 developmental biology
Molecular Probes
Medicine
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- eLife, Vol 7 (2018), eLife, ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
- Accession number :
- edsair.doi.dedup.....ba91100a44a3d9b67ccf3f2841cb55bf
- Full Text :
- https://doi.org/10.17615/xwch-gy13