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1. Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome

Author

Magaz, Marta, Giudicelli-Lett, Heloïse, Abraldes, Juan G., Nicoară-Farcău, Oana, Turon, Fanny, Rajoriya, Neil, Goel, Ashish, Raymenants, Karlien, Hillaire, Sophie, Téllez, Luis, Elkrief, Laure, Procopet, Bogdan, Orts, Lara, Nery, Filipe, Shukla, Akash, Larrue, Hélène, Degroote, Helena, Aguilera, Victoria, Llop, Elba, Turco, Laura, Indulti, Federica, Gioia, Stefania, Tosetti, Giulia, Bitto, Niccolò, Becchetti, Chiara, Alvarado, Edilmar, Roig, Cristina, Diaz, Raquel, Praktiknjo, Michael, Konicek, Anna-Lena, Olivas, Pol, Fortea, José Ignacio, Masnou, Helena, Puente, Ángela, Ardèvol, Alba, Navascués, Carmen A., Romero-Gutiérrez, Marta, Scheiner, Bernhard, Semmler, Georg, Mandorfer, Mattias, Damião, Filipe, Baiges, Anna, Ojeda, Asunción, Simón-Talero, Macarena, González-Alayón, Carlos, Díaz, Alba, García-Criado, Ángeles, De Gottardi, Andrea, Hernández-Guerra, Manuel, Genescà, Joan, Drilhon, Nicolas, Noronha Ferreira, Carlos, Reiberger, Thomas, Rodríguez, Manuel, Morillas, Rosa María, Crespo, Javier, Trebicka, Jonel, Bañares, Rafael, Villanueva, Càndid, Berzigotti, Annalisa, Primignani, Massimo, La Mura, Vincenzo, Riggio, Oliviero, Schepis, Filippo, Verhelst, Xavier, Calleja, José Luis, Bureau, Christophe, Albillos, Agustín, Nevens, Frederik, Hernández-Gea, Virginia, Tripathi, Dhiraj, Rautou, Pierre-Emmanuel, and García-Pagán, Juan Carlos

Published
2025
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2. Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

Author

Paternostro, Rafael, Kwanten, Wilhelmus J., Hofer, Benedikt Silvester, Semmler, Georg, Bagdadi, Ali, Luzko, Irina, Hernández-Gea, Virginia, Graupera, Isabel, García-Pagán, Juan Carlos, Saltini, Dario, Indulti, Federica, Schepis, Filippo, Moga, Lucile, Rautou, Pierre-Emmanuel, Llop, Elba, Téllez, Luis, Albillos, Agustín, Fortea, Jose Ignacio, Puente, Angela, Tosetti, Giulia, Primignani, Massimo, Zipprich, Alexander, Vuille-Lessard, Elise, Berzigotti, Annalisa, Taru, Madalina-Gabriela, Taru, Vlad, Procopet, Bogdan, Jansen, Christian, Praktiknjo, Michael, Gu, Wenyi, Trebicka, Jonel, Ibanez-Samaniego, Luis, Bañares, Rafael, Rivera-Esteban, Jesús, Pericas, Juan M., Genesca, Joan, Alvarado, Edilmar, Villanueva, Candid, Larrue, Helene, Bureau, Christophe, Laleman, Wim, Ardevol, Alba, Masnou, Helena, Vanwolleghem, Thomas, Trauner, Michael, Mandorfer, Mattias, Francque, Sven, and Reiberger, Thomas

Published
2024
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3. Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: A post hoc analysis of the PREDESCI trial

Author

Villanueva, Càndid, Albillos, Agustín, Genescà, Joan, Garcia-Pagan, Juan C., Calleja, José L., Aracil, Carles, Bañares, Rafael, Morillas, Rosa M., Poca, María, Peñas, Beatriz, Augustin, Salvador, Abraldes, Juan G., Alvarado, Edilmar, Torres, Ferran, Bosch, Jaume, Dajti, Elton, Berzigotti, Annalisa, Brujats, Anna, García-Pagán, Juan C., and Colecchia, Antonio

Published
2024
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4. Decompensation in Advanced Nonalcoholic Fatty Liver Disease May Occur at Lower Hepatic Venous Pressure Gradient Levels Than in Patients With Viral Disease

Author

Bassegoda, Octavi, Olivas, Pol, Turco, Laura, Mandorfer, Mattias, Serra-Burriel, Miquel, Tellez, Luis, Kwanten, Wilhelmus, Laroyenne, Alexia, Farcau, Oana, Alvarado, Edilmar, Moga, Lucile, Vuille-Lessard, Elise, Fortea, Jose Ignacio, Ibañez, Luis, Tosetti, Giulia, Vanwolleghem, Thomas, Larrue, Hélène, Burgos-Santamaría, Diego, Stefanescu, Horia, Paternostro, Rafael, Cippitelli, Annalisa, Lens, Sabela, Augustin, Salvador, Llop, Elba, Laleman, Wim, Trebicka, Jonel, Chang, Johannes, Masnou, Helena, Zipprich, Alexander, Miceli, Francesca, Semmler, Georg, Forns, Xavier, Primignani, Massimo, Bañares, Rafael, Puente, Angela, Berzigotti, Annalisa, Rautou, Pierre Emmanuel, Villanueva, Candid, Ginès, Pere, Garcia-Pagan, J.C., Procopet, Bogdan, Bureau, Cristophe, Albillos, Agustin, Francque, Sven, Reiberger, Thomas, Schepis, Filippo, Graupera, Isabel, and Hernandez-Gea, Virginia

Published
2022
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6. Liver Transplantation for Porto-Sinusoidal Vascular Liver Disorder: Long-term Outcome

Author

Magaz, Marta, Giudicelli-Lett, Heloïse, Nicoară-Farcău, Oana, Rajoriya, Neil, Goel, Ashish, Raymenants, Karlien, Hillaire, Sophie, Crespo, Gonzalo, Téllez, Luis, Elkrief, Laure, Fondevila, Constantino, Orts, Lara, Nery, Filipe, Shukla, Akash, Larrue, Hélène, Fundora, Yiliam, Degroote, Helena, Aguilera, Victoria, LLop, Elba, Turco, Laura, Indulti, Federica, Gioia, Stefania, Tosetti, Giulia, Bitto, Niccolò, Becchetti, Chiara, Alvarado, Edilmar, Roig, Cristina, Diaz, Raquel, Praktiknjo, Michael, Konicek, Anna-Lena, Soy, Guillem, Olivas, Pol, Fortea, José Ignacio, Masnou, Helena, Puente, Ángela, Ardèvol, Alba, Álvarez-Navascués, Carmen, Romero, Marta, Scheiner, Bernhard, Semmler, Georg, Mandorfer, Mattias, Damião, Filipe, Baiges, Anna, Turon, Fanny, Simón-Talero, Macarena, González-Alayón, Carlos, Díaz, Alba, García-Criado, Ángeles, de Gottardi, Andrea, Reverter, Enric, Blasi, Annabel, Genescà, Joan, Roux, Olivier, Francoz, Claire, Noronha Ferreira, Carlos, Reiberger, Thomas, Rodríguez, Manuel, Morillas, Rosa María, Crespo, Javier, Trebicka, Jonel, Bañares, Rafael, Villanueva, Càndid, Berzigotti, Annalisa, Primignani, Massimo, La Mura, Vincenzo, Riggio, Oliviero, Schepis, Filippo, Procopet, Bogdan, Verhelst, Xavier, Calleja, José Luis, Bureau, Christophe, Albillos, Agustín, Nevens, Frederik, Hernández-Gea, Virginia, Tripathi, Dhiraj, Rautou, Pierre-Emmanuel, Durand, François, and García-Pagán, Juan Carlos

Published
2022
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8. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Author

Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose María, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gomez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria Vega, Rudler, Marika, Alvarado, Edilmar, Perez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, and Albillos, Agustín

Published
2021
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9. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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10. Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics.

Author

Laghi, Luca, Ortiz, Maria Àngels, Rossi, Giacomo, Román, Eva, Mengucci, Carlo, Cantó, Elisabet, Biagini, Lucia, Sánchez, Elisabet, Mulet, Maria, García-Osuna, Álvaro, Urgell, Eulàlia, Kaur, Naujot, Poca, Maria, Padrós, Josep, Nadal, Maria Josep, Cuyàs, Berta, Alvarado, Edilmar, Vidal, Silvia, Juanes, Elena, and Ferrero-Gregori, Andreu

Subjects
SHORT-chain fatty acids, HOME rehabilitation, AMINO acids, FATTY acids, ORNITHINE
Abstract

Frailty in cirrhosis or advanced chronic liver disease (ACLD) is a relevant prognostic factor. In the present study, we aimed to analyze potential biomarkers associated with frailty and its improvement in patients with ACLD. We analyzed the serum of outpatients with ACLD who participated in a previous study (Román, Hepatol Commun 2024) in which frailty was assessed using the liver frailty index (LFI), and patients who were frail or prefrail were randomized to a multifactorial intervention (home exercise, branched-chain amino acids, and probiotics) or control for 12 months. We determined a biomarker battery of inflammation, bacterial translocation, and liver damage in blood and urine and blood metabolomics by 1H-NMR. Thirty-seven patients were included. According to the LFI, 32 patients were frail or prefrail, and 5 were robust. At baseline, LFI correlated with LBP, sCD163, mtDNA, FGF-21, urinary NGAL, urinary claudin-3, and the metabolites mannose, ethanol, and isoleucine. During the study, patients in the intervention group showed an improvement in LFI and a decrease in CRP, LBP, sCD163, and ccK18 compared to the control group. Metabolomics showed a decrease in dimethyl sulfone and creatinine and an increase in malonate, ornithine, isoleucine, and valine in the intervention group. We conclude that frailty in patients with ACLD is associated with biomarkers of systemic inflammation, bacterial translocation, and liver damage, and alterations of amino acid and short-chain fatty acid metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Cristophe, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susanag, Gluud, Liselotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Weiss, Emmanuel, Catalina, Maria-Vega, Erasmus, Hans-Peter, Uschner, Frank Erhard, Schulz, Martin, Brol, Maximilian J., Praktiknjo, Michael, Chang, Johannes, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Robic, Marie Angèle, Conejo, Irene, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar, Guardascione, Maria Anna, Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Pavesi, Marco, Garcia-Pagán, Juan Carlos, Jansen, Christian, and Bañares, Rafael

Published
2020
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12. Lowering Portal Pressure Improves Outcomes of Patients With Cirrhosis, With or Without Ascites: A Meta-Analysis

Author

Turco, Laura, Villanueva, Candid, La Mura, Vincenzo, García-Pagán, Juan Carlos, Reiberger, Thomas, Genescà, Joan, Groszmann, Roberto J., Sharma, Barjesh C., Merkel, Carlo, Bureau, Christophe, Alvarado, Edilmar, Abraldes, Juan Gonzalez, Albillos, Agustin, Bañares, Rafael, Peck-Radosavljevic, Markus, Augustin, Salvador, Sarin, Shiv K., Bosch, Jaime, and García-Tsao, Guadalupe

Published
2020
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13. β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial

Author

Villanueva, Càndid, Albillos, Agustín, Genescà, Joan, Garcia-Pagan, Joan C, Calleja, José L, Aracil, Carles, Bañares, Rafael, Morillas, Rosa M, Poca, María, Peñas, Beatriz, Augustin, Salvador, Abraldes, Juan G, Alvarado, Edilmar, Torres, Ferran, and Bosch, Jaume

Published
2019
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15. Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

Author

Augustin, Salvador, Llop, Elba, Arraez, Dalia Morales, Hernández Mesa, Goretti, Martinez, Javier, Reverter, Enric, Seijo, Susana, Turon, Fanny, Miñana, Josep, Buenestado, Juan, Reñe, Josep M., Navacués, Carmen A., Planas, Ramon, Morillas, Rosa M., Bellot, Pau, Such, Jose, Vergara, Mercedes, Puente, Angela, de la Pena, Joaquin, Mera Calviño, José, Rivas Moral, Laura, Pavel, Oana, Alvarado, Edilmar, Ardevol, Alba, Girbau, Anna, Cachero, Alba, Arnaiz, Joan Albert, Berzigotti, Annalisa, Pich, Judit, Rios, Jose, Saenz, Rosa, Millan, Laura, Beleta, Helena, Ramos, Núria, Abraldes, Juan G., Villanueva, Candid, Aracil, Carles, Turnes, Juan, Hernandez-Guerra, Manuel, Genesca, Joan, Rodriguez, Manuel, Castellote, Jose, García-Pagán, Juan Carlos, Torres, Ferran, Calleja, Jose Luis, Albillos, Agustin, and Bosch, Jaime

Published
2016
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16. Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding

Author

Rudler, Marika, Hernández-Gea, Virginia, Procopet, Bogdan Dumitru, Giráldez, Alvaro, Amitrano, Lucio, Villanueva, Càndid, Ibañez, Luis, Silva-Junior, Gilberto, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise Lotte, Noronha Ferreira, Carlos, Canete, Nouria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Larrue, Hélène, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Schwarzer, Remy, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Gonzalez, Javier Martínez, Catalina, Maria Vega, Albillos, Agustín, Alvarado, Edilmar, Guardascione, Maria Anna, Mallet, Maxime, Tripon, Simona, Casanovas, Georgina, Bosch, Jaume, Garcia-Pagan, Juan-Carlos, Thabut, Dominique, Rudler, Marika, Hernández-Gea, Virginia, Procopet, Bogdan Dumitru, Giráldez, Alvaro, Amitrano, Lucio, Villanueva, Càndid, Ibañez, Luis, Silva-Junior, Gilberto, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise Lotte, Noronha Ferreira, Carlos, Canete, Nouria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Larrue, Hélène, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Schwarzer, Remy, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Gonzalez, Javier Martínez, Catalina, Maria Vega, Albillos, Agustín, Alvarado, Edilmar, Guardascione, Maria Anna, Mallet, Maxime, Tripon, Simona, Casanovas, Georgina, Bosch, Jaume, Garcia-Pagan, Juan-Carlos, and Thabut, Dominique

Abstract

Background: A pre-emptive transjugular intrahepatic portosystemic shunt (pTIPS) reduces mortality in high-risk patients with cirrhosis (Child-Pugh C/B+active bleeding) with acute variceal bleeding (AVB). Real-life studies point out that <15% of patients eligible for pTIPS ultimately undergo transjugular intrahepatic portosystemic shunt (TIPS) due to concerns about hepatic encephalopathy (HE). The outcome of patients undergoing pTIPS with HE is unknown. We aimed to (1) assess the prevalence of HE in patients with AVB; (2) evaluate the outcome of patients presenting HE at admission after pTIPS; and (3) determine if HE at admission is a risk factor for death and post-TIPS HE. Patients and methods: This is an observational study including 2138 patients from 34 centres between October 2011 and May 2015. Placement of pTIPS was based on individual centre policy. Patients were followed up to 1 year, death or liver transplantation. Results: 671 of 2138 patients were considered at high risk, 66 received pTIPS and 605 endoscopic+drug treatment. At admission, HE was significantly more frequent in high-risk than in low-risk patients (39.2% vs 10.6%, p<0.001). In high-risk patients with HE at admission, pTIPS was associated with a lower 1-year mortality than endoscopic+drug (HR 0.374, 95% CI 0.166 to 0.845, p=0.0181). The incidence of HE was not different between patients treated with pTIPS and endoscopic+drug (38.2% vs 38.7%, p=0.9721), even in patients with HE at admission (56.4% vs 58.7%, p=0.4594). Age >56, shock, Model for End-Stage Liver Disease score >15, endoscopic+drug treatment and HE at admission were independent factors of death in high-risk patients. Conclusion: pTIPS is associated with better survival than endoscopic treatment in high-risk patients with cirrhosis with variceal bleeding displaying HE at admission.

Published
2023

17. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Instituto de Salud Carlos III, Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramón, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos N., Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Alessandra Dell'Era, Senzolo, Marco, Abraldes, Juan G., Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria Anna, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martínez, Javier, Robic, Marie Angèle, Jansen, Christian, Calleja, José Luis, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagán, Juan Carlos, Genescà, Joan, for the International Variceal Bleeding Observational Study Group; Baveno Cooperation, Instituto de Salud Carlos III, Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramón, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos N., Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Alessandra Dell'Era, Senzolo, Marco, Abraldes, Juan G., Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria Anna, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martínez, Javier, Robic, Marie Angèle, Jansen, Christian, Calleja, José Luis, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagán, Juan Carlos, Genescà, Joan, and for the International Variceal Bleeding Observational Study Group; Baveno Cooperation

Abstract

[Background & Aims] Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis., [Methods] Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD., [Results] The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29–0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH., [Conclusions] Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2023

18. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Villagrasa, Ares, Hernandez-Gea, Virginia, Bataller, Ramon, Giraldez, Alvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J. M., Castellote, Jose, Rodrigues, Susana L., Gluud, Lise N., Ferreira, Carlos, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf L., Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco G., Abraldes, Juan, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gomez, Manuel, Tantau, Marcel A., Guardascione, Maria, Alvarado, Edilmar, Rudler, Marika, Banares, Rafael, Martinez, Javier A., Robic, Marie, Jansen, Christian L., Calleja, Jose, Nevens, Frederik, Gluud, Lise Lotte, Bosch, Jaime, Ventura-Cots, Meritxell C., Garcia-Pagan, Juan, Genesca, Joan, Villagrasa, Ares, Hernandez-Gea, Virginia, Bataller, Ramon, Giraldez, Alvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J. M., Castellote, Jose, Rodrigues, Susana L., Gluud, Lise N., Ferreira, Carlos, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf L., Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco G., Abraldes, Juan, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gomez, Manuel, Tantau, Marcel A., Guardascione, Maria, Alvarado, Edilmar, Rudler, Marika, Banares, Rafael, Martinez, Javier A., Robic, Marie, Jansen, Christian L., Calleja, Jose, Nevens, Frederik, Gluud, Lise Lotte, Bosch, Jaime, Ventura-Cots, Meritxell C., Garcia-Pagan, Juan, and Genesca, Joan

Abstract

Background & AimsAlcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. MethodsMulticentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. ResultsThe prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. ConclusionsContrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2023

19. A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis

Author

Laghi, Luca, primary, Román, Eva, additional, Lan, Qiuyu, additional, Nieto, Juan Camilo, additional, Canalda-Baltrons, Aleix, additional, Poca, Maria, additional, Sánchez-Rodríguez, Maria B., additional, Clària, Joan, additional, Alvarado, Edilmar, additional, Cuyàs, Berta, additional, Sánchez, Elisabet, additional, Vidal, Sílvia, additional, Guarner, Carlos, additional, Escorsell, Àngels, additional, Manichanh, Chaysavanh, additional, and Soriano, German, additional

Published
2023
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20. Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding

Author

Rudler, Marika, primary, Hernández-Gea, Virginia, additional, Procopet, Bogdan Dumitru, additional, Giráldez, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Càndid, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Bañares, Rafael, additional, Krag, Aleksander, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose Maria, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise Lotte, additional, Noronha Ferreira, Carlos, additional, Canete, Nouria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell’era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Larrue, Hélène, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Schwarzer, Remy, additional, Jansen, Christian, additional, Robic, Marie-Angèle, additional, Conejo, Irene, additional, Martínez Gonzalez, Javier, additional, Catalina, Maria Vega, additional, Albillos, Agustín, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Mallet, Maxime, additional, Tripon, Simona, additional, Casanovas, Georgina, additional, Bosch, Jaume, additional, Garcia-Pagan, Juan-Carlos, additional, and Thabut, Dominique, additional

Published
2022
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21. Reply

Author

Villanueva, Càndid, Graupera, Isabel, and Alvarado, Edilmar

Published
2017
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22. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.

Author

UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Ventura-Cots, Meritxell, Argemi, Josepmaria, Jones, Patricia D, Lackner, Carolin, El Hag, Mohamed, Abraldes, Juan G, Alvarado, Edilmar, Clemente, Ana, Ravi, Samitha, Alves, Antonio, Alboraie, Mohamed, Altamirano, Jose, Barace, Sergio, Bosques, Francisco, Brown, Robert, Caballeria, Juan, Cabezas, Joaquin, Carvalhana, Sofia, Cortez-Pinto, Helena, Costa, Adilia, Degré, Delphine, Fernandez-Carillo, Carlos, Ganne-Carrie, Nathalie, Garcia-Tsao, Guadalupe, Genesca, Joan, Koskinas, John, Lanthier, Nicolas, Louvet, Alexandre, Lozano, Juan José, Lucey, Michael R, Masson, Steven, Mathurin, Philippe, Mendez-Sanchez, Nahum, Miquel, Rosa, Moreno, Christophe, Mounajjed, Taofic, Odena, Gemma, Kim, Won, Sancho-Bru, Pau, Warren Sands, R, Szafranska, Justyna, Verset, Laurine, Schnabl, Bern, Sempoux, Christine, Shah, Vijay, Shawcross, Debbie Lindsay, Stauber, Rudolf E, Straub, Beate K, Verna, Elizabeth, Tiniakos, Dina, Trépo, Eric, Vargas, Victor, Villanueva, Càndid, Woosley, John T, Ziol, Marianne, Mueller, Sebastian, Starkel, Peter, Bataller, Ramon, UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, Ventura-Cots, Meritxell, Argemi, Josepmaria, Jones, Patricia D, Lackner, Carolin, El Hag, Mohamed, Abraldes, Juan G, Alvarado, Edilmar, Clemente, Ana, Ravi, Samitha, Alves, Antonio, Alboraie, Mohamed, Altamirano, Jose, Barace, Sergio, Bosques, Francisco, Brown, Robert, Caballeria, Juan, Cabezas, Joaquin, Carvalhana, Sofia, Cortez-Pinto, Helena, Costa, Adilia, Degré, Delphine, Fernandez-Carillo, Carlos, Ganne-Carrie, Nathalie, Garcia-Tsao, Guadalupe, Genesca, Joan, Koskinas, John, Lanthier, Nicolas, Louvet, Alexandre, Lozano, Juan José, Lucey, Michael R, Masson, Steven, Mathurin, Philippe, Mendez-Sanchez, Nahum, Miquel, Rosa, Moreno, Christophe, Mounajjed, Taofic, Odena, Gemma, Kim, Won, Sancho-Bru, Pau, Warren Sands, R, Szafranska, Justyna, Verset, Laurine, Schnabl, Bern, Sempoux, Christine, Shah, Vijay, Shawcross, Debbie Lindsay, Stauber, Rudolf E, Straub, Beate K, Verna, Elizabeth, Tiniakos, Dina, Trépo, Eric, Vargas, Victor, Villanueva, Càndid, Woosley, John T, Ziol, Marianne, Mueller, Sebastian, Starkel, Peter, and Bataller, Ramon

Abstract

Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking. Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective cohort of patients with ndALD (n=110) and a prospective cohort of patients with AH (n=225). Clinical, analytical, immunohistochemistry and hepatic RNA microarray analysis of both disease phenotypes were performed. Age and mean alcohol intake were similar in both groups. AH patients had greater aspartate amino transferase/alanine amino transferase ratio and lower gamma-glutamyl transferase levels than in ndALD patients. Patients with AH demonstrated profound liver failure and increased mortality. One-year mortality was 10% in ndALD and 50% in AH. Histologically, steatosis grade, ballooning and pericellular fibrosis were similar in both groups, while advanced fibrosis, Mallory-Denk bodies, bilirubinostasis, severe neutrophil infiltration and ductular reaction were more frequent among AH patients. Transcriptome analysis revealed a profound gene dysregulation within both phenotypes when compare to controls. While ndALD was characterised by deregulated expression of genes involved in matrisome and immune response, the development of AH resulted in a marked deregulation of genes involved in hepatocyte reprogramming and bile acid metabolism. Despite comparable alcohol intake, AH patients presented with worse liver function compared with ndALD patients. Bilirubinostasis, severe fibrosis and ductular reaction were prominent features of AH. AH patients exhibited a more profound deregulation of gene expression compared with ndALD patients.

Published
2022

23. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.

Author

Ventura-Cots, Meritxell, Argemi, Josepmaria, Jones, Patricia D, Lackner, Carolin, El Hag, Mohamed, Abraldes, Juan G, Alvarado, Edilmar, Clemente, Ana, Ravi, Samhita, Alves, Antonio, Alboraie, Mohamed, Altamirano, Jose, Barace, Sergio, Bosques, Francisco, Brown, Robert, Caballeria, Juan, Cabezas, Joaquin, Carvalhana, Sofia, Cortez-Pinto, Helena, Costa, Adilia, Degré, Delphine, Fernandez-Carrillo, Carlos, Ganne-Carrie, Nathalie, Garcia-Tsao, Guadalupe, Genesca, Joan, Koskinas, John, Lanthier, Nicolas, Louvet, Alexandre, Lozano, Juan José, Lucey, Michael R, Masson, Steven, Mathurin, Philippe, Mendez-Sanchez, Nahum, Miquel, Rosa, Moreno, Christophe, Mounajjed, Taofic, Odena, Gemma, Kim, Won, Sancho-Bru, Pau, Warren Sands, R, Szafranska, Justyna, Verset, Laurine, Schnabl, Bernd, Sempoux, Christine, Shah, Vijay H, Shawcross, Debbie Lindsay, Stauber, Rudolf, Straub, Beate K, Verna, Elizabeth, Tiniakos, Dina, Trepo, Eric, Vargas, Victor, Villanueva, Cándido, Woosley, John T, Ziol, Marianne, Mueller, Sebastian, Stärkel, Peter, Bataller, Ramon, Ventura-Cots, Meritxell, Argemi, Josepmaria, Jones, Patricia D, Lackner, Carolin, El Hag, Mohamed, Abraldes, Juan G, Alvarado, Edilmar, Clemente, Ana, Ravi, Samhita, Alves, Antonio, Alboraie, Mohamed, Altamirano, Jose, Barace, Sergio, Bosques, Francisco, Brown, Robert, Caballeria, Juan, Cabezas, Joaquin, Carvalhana, Sofia, Cortez-Pinto, Helena, Costa, Adilia, Degré, Delphine, Fernandez-Carrillo, Carlos, Ganne-Carrie, Nathalie, Garcia-Tsao, Guadalupe, Genesca, Joan, Koskinas, John, Lanthier, Nicolas, Louvet, Alexandre, Lozano, Juan José, Lucey, Michael R, Masson, Steven, Mathurin, Philippe, Mendez-Sanchez, Nahum, Miquel, Rosa, Moreno, Christophe, Mounajjed, Taofic, Odena, Gemma, Kim, Won, Sancho-Bru, Pau, Warren Sands, R, Szafranska, Justyna, Verset, Laurine, Schnabl, Bernd, Sempoux, Christine, Shah, Vijay H, Shawcross, Debbie Lindsay, Stauber, Rudolf, Straub, Beate K, Verna, Elizabeth, Tiniakos, Dina, Trepo, Eric, Vargas, Victor, Villanueva, Cándido, Woosley, John T, Ziol, Marianne, Mueller, Sebastian, Stärkel, Peter, and Bataller, Ramon

Abstract

Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

24. Clinical, histological and molecular profiling of different stages of alcohol-related liver disease

Author

Ventura-Cots, Meritxell, primary, Argemi, Josepmaria, additional, Jones, Patricia D, additional, Lackner, Carolin, additional, El Hag, Mohamed, additional, Abraldes, Juan G, additional, Alvarado, Edilmar, additional, Clemente, Ana, additional, Ravi, Samhita, additional, Alves, Antonio, additional, Alboraie, Mohamed, additional, Altamirano, Jose, additional, Barace, Sergio, additional, Bosques, Francisco, additional, Brown, Robert, additional, Caballeria, Juan, additional, Cabezas, Joaquin, additional, Carvalhana, Sofia, additional, Cortez-Pinto, Helena, additional, Costa, Adilia, additional, Degré, Delphine, additional, Fernandez-Carrillo, Carlos, additional, Ganne-Carrie, Nathalie, additional, Garcia-Tsao, Guadalupe, additional, Genesca, Joan, additional, Koskinas, John, additional, Lanthier, Nicolas, additional, Louvet, Alexandre, additional, Lozano, Juan José, additional, Lucey, Michael R, additional, Masson, Steven, additional, Mathurin, Philippe, additional, Mendez-Sanchez, Nahum, additional, Miquel, Rosa, additional, Moreno, Christophe, additional, Mounajjed, Taofic, additional, Odena, Gemma, additional, Kim, Won, additional, Sancho-Bru, Pau, additional, Warren Sands, R, additional, Szafranska, Justyna, additional, Verset, Laurine, additional, Schnabl, Bern, additional, Sempoux, Christine, additional, Shah, Vijay, additional, Shawcross, Debbie Lindsay, additional, Stauber, Rudolf E, additional, Straub, Beate K, additional, Verna, Elizabeth, additional, Tiniakos, Dina, additional, Trépo, Eric, additional, Vargas, Victor, additional, Villanueva, Càndid, additional, Woosley, John T, additional, Ziol, Marianne, additional, Mueller, Sebastian, additional, Stärkel, Peter, additional, and Bataller, Ramon, additional

Published
2022
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25. Liver Transplantation for Porto-sinusoidal Vascular Liver Disorder: Long-term Outcome

Author

Magaz, Marta, Giudicelli-Lett, Heloïse, Nicoară-Farcău, Oana, Rajoriya, Neil, Goel, Ashish, Raymenants, Karlien, Hillaire, Sophie, Crespo, Gonzalo, Téllez, Luis, Elkrief, Laure, Fondevila, Constantino, Orts, Lara, Nery, Filipe, Shukla, Akash, Larrue, Hélène, Fundora, Yiliam, Degroote, Helena, Aguilera, Victoria, LLop, Elba, Turco, Laura, Indulti, Federica, Gioia, Stefania, Tosetti, Giulia, Bitto, Niccolò, Becchetti, Chiara, Alvarado, Edilmar, Roig, Cristina, Diaz, Raquel, Praktiknjo, Michael, Konicek, Anna-Lena, Soy, Guillem, Olivas, Pol, Fortea, José Ignacio, Masnou, Helena, Puente, Ángela, Ardèvol, Alba, Álvarez-Navascués, Carmen, Romero, Marta, Scheiner, Bernhard, Semmler, Georg, Mandorfer, Mattias, Damião, Filipe, Baiges, Anna, Turon, Fanny, Simón-Talero, Macarena, González-Alayón, Carlos, Díaz, Alba, García-Criado, Ángeles, de Gottardi, Andrea, Reverter, Enric, Blasi, Annabel, Genescà, Joan, Roux, Olivier, Francoz, Claire, Noronha Ferreira, Carlos, Reiberger, Thomas, Rodríguez, Manuel, Morillas, Rosa María, Crespo, Javier, Trebicka, Jonel, Bañares, Rafael, Villanueva, Càndid, Berzigotti, Annalisa, Primignani, Massimo, La Mura, Vincenzo, Riggio, Oliviero, Schepis, Filippo, Procopet, Bogdan, Verhelst, Xavier, Calleja, José Luis, Bureau, Christophe, Albillos, Agustín, Nevens, Frederik, Hernández-Gea, Virginia, Tripathi, Dhiraj, Rautou, Pierre-Emmanuel, Durand, François, and García-Pagán, Juan Carlos

Published
2023
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26. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramon, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J M, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L, Ferreira, Carlos N, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria A, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martinez, Javier, Robic, Marie A, Jansen, Christian, Calleja, Jose L, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagan, Juan C, and Genescà, Joan

Subjects
alcohol, upper gastrointestinal bleeding, cirrhosis, alcohol-related hepatitis, 610 Medicine & health, abstinence
Abstract

BACKGROUND & AIMS Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. METHODS Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. RESULTS The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. CONCLUSIONS Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2021
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27. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Author

Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, European Commission, Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, José Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, María Vega, Rudler, Marika, Alvarado, Edilmar, Pérez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, Albillos, Agustín, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, European Commission, Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, José Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, María Vega, Rudler, Marika, Alvarado, Edilmar, Pérez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, and Albillos, Agustín

Abstract

[Background & Aims] Antibiotic prophylaxis reduces the risk of infection and mortality in patients with cirrhosis and acute variceal bleeding (AVB). This study examines the incidence of, and risk factors for, bacterial infections during hospitalization in patients with AVB on antibiotic prophylaxis., [Methods] A post hoc analysis was performed using the database of an international, multicenter, observational study designed to examine the role of pre-emptive transjugular intrahepatic portosystemic shunts in patients with cirrhosis and AVB. Data were collected on patients with cirrhosis hospitalized for AVB (n = 2,138) from a prospective cohort (October 2013-May 2015) at 34 referral centers, and a retrospective cohort (October 2011-September 2013) at 19 of these centers. The primary outcome was incidence of bacterial infection during hospitalization., [Results] A total of 1,656 patients out of 1,770 (93.6%) received antibiotic prophylaxis; third-generation cephalosporins (76.2%) and quinolones (19.0%) were used most frequently. Of the patients on antibiotic prophylaxis, 320 patients developed bacterial infection during hospitalization. Respiratory infection accounted for 43.6% of infections and for 49.7% of infected patients, and occurred early after admission (median 3 days, IQR 1-6). On multivariate analysis, respiratory infection was independently associated with Child-Pugh C (odds ratio [OR] 3.1; 95% CI 1.4-6.7), grade III-IV encephalopathy (OR 2.8; 95% CI 1.8-4.4), orotracheal intubation for endoscopy (OR 2.6; 95% CI 1.8-3.8), nasogastric tube placement (OR 1.7; 95% CI 1.2-2.4) or esophageal balloon tamponade (OR 2.4; 95% CI 1.2-4.9)., [Conclusion] Bacterial infections develop in almost one-fifth of patients with AVB despite antibiotic prophylaxis. Respiratory infection is the most frequent, is an early event after admission, and is associated with advanced liver failure, severe hepatic encephalopathy and use of nasogastric tube, orotracheal intubation for endoscopy or esophageal balloon tamponade.

Published
2021

28. Impact of direct-acting antiviral (DAA) treatment for hepatitis C on pulmonary hemodynamics

Author

Orizaga Franco, Tanya Elisa, primary, Blanco Vich, Isabel, additional, Slens, Sabela, additional, Alvarado, Edilmar, additional, Mariño, Zoe, additional, Torras, Xavier, additional, Baiges, Anna, additional, Turon, Fanny, additional, Hernández-Gea, Virginia, additional, Villanueva, Càndid, additional, Moises, Jorge, additional, Forns, Xavier, additional, García-Pagán, Joan Carles, additional, and Barberà Mir, Joan Albert, additional

Published
2020
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29. Early-tips should be performed in high-risk cirrhotic patients despite the presence of hepatic encephalopathy at admission

Author

Rudler, Marika, primary, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Jonel, Trebicka, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose María, additional, Alonso, José Castellote, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Cañete, Nuria, additional, Ferlitsch, Prof. Dr. Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romanno, additional, Dell’Era, Alessandra, additional, Abraldes, Juan G., additional, Barcelo, Rafael, additional, Senzolo, Marco, additional, Gomez, Manuel Romero, additional, Zipprich, Alexander, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Torres, Ferran, additional, Nevens, Frederik, additional, Calleja Panero, José Luis, additional, Casanovas, Georgina, additional, Jansen, Christian, additional, Albillos, Agustin, additional, Maria, Guardascione, additional, Alvarado, Edilmar, additional, Casas, Meritxell, additional, Robic, Marie-Angèle, additional, Catalina, María-Vega, additional, Sosa, Irene Conejo, additional, Maxime, Mallet, additional, Simona, Tripon, additional, Bosch, Jaime, additional, Garcia Pagan, Juan Carlos, additional, and Thabut, Dominique, additional

Published
2020
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30. Hemodynamic effects of direct-acting antivirals in patients with hepatitis-C virus-associated cirrhosis and portal hypertension non responsive to beta-blockers

Author

Alvarado, Edilmar, primary, Lens, Sabela, additional, Ardevol, Alba, additional, Guix, Marta García, additional, Baiges, Anna, additional, Brujats, Ana, additional, Gonzalez, Laura Gonzalez, additional, Mariño, Zoe, additional, Torras, Xavier, additional, Moya, Adolfo Gallego, additional, Hernandez-Gea, Virginia, additional, Forns, Xavier, additional, Garcia Pagan, Juan Carlos, additional, and Villanueva, Candid, additional

Published
2020
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32. Natural history of polycytemia vera and essential thrombocythemia presenting with splanchnic vein thrombosis

Author

Magaz, Marta, primary, Álvarez-Larrán, Alberto, additional, Pereira, Arturo, additional, Turon, Fanny, additional, Hernández-Boluda, Juan Carlos, additional, Alvarado, Edilmar, additional, de Riba, Bea, additional, Alvarez-Navascues, Mari Carmen, additional, Luis, Tellez, additional, Puente, Angela, additional, Fortea, Jose Ignacio, additional, Diaz, Raquel, additional, Romero-Gutiérrez, Marta, additional, González-Alayón, Carlos, additional, Llop, Elba, additional, Ferreira, Carlos Noronha, additional, Ferrusquia, José, additional, Baiges, Anna, additional, Calleja Panero, José Luis, additional, Crespo, Javier, additional, Albillos, Agustin, additional, Bañares, Rafael, additional, Villanueva, Candid, additional, Hernandez-Gea, Virginia, additional, Cervantes, Francisco, additional, and Garcia Pagan, Juan Carlos, additional

Published
2020
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33. OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., Stanley, Adrian J., Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez, Alvaro, Sanchez, Candido V., Thabut, Dominique, Ibanez-Samaniego, Luis, Martinez, Javier, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, Jose M., Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L., Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dellera, Alessandra, Senzolo, Marco, Abraldes, Juan, Romero-Gomez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Jansen, Christian, Robic, Marie A., Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar A., Guardascione, Maria A., Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Garcia-Pagan, Juan C., and Krag, Aleksander

Published
2019
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34. 551 OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., primary, Stanley, Adrian J., additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giráldez, Alvaro, additional, Sanchez, Cándido V., additional, Thabut, Dominique, additional, Ibañez-Samaniego, Luís, additional, Martinez, Javier, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose M., additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L., additional, Ferreira, Carlos Noronha, additional, Barceló, Rafael, additional, Cañete, Nuria, additional, Rodriguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose L., additional, Grønbæk, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dellera, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Jansen, Christian, additional, Robic, Marie A., additional, Conejo, Irene, additional, Catalina, María-Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar A., additional, Guardascione, Maria A., additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, Garcia-Pagán, Juan C., additional, and Krag, Aleksander, additional

Published
2019
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35. SAT-036-Prognostic implications of encephalopathy to adequately define differentiated stages of decompensated cirrhosis

Author

Guix, Marta García, primary, Alvarado, Edilmar, additional, Ardevol, Alba, additional, montañés, rosa, additional, Cuyas, Berta, additional, riba, bea de, additional, gonzalez, carlos, additional, brujats, ana, additional, Poca, Maria, additional, Torras, Xavier, additional, Guarner, Carlos, additional, Soriano, German, additional, and Villanueva, Candid, additional

Published
2019
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36. SAT-079-Respiratory infection in patients with cirrhosis and acute variceal bleeding on antibiotic prophylaxis: A multicenter observational study of 2138 patients

Author

Martinez, Javier, primary, luis, Tellez, additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Genesca, Joan, additional, christophe, Bureau, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose María, additional, Castellote, José, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodriguez, Manuel, additional, Ferlitsch, Prof. Dr. Arnulf, additional, Mundi, Jose Luis, additional, Granbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romanno, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan, additional, Romero-gómez, Manolo, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Panero, José Luis Calleja, additional, Jansen, Christian, additional, Robic, Marie Angele, additional, Conejo, Irene, additional, Catalina, Maria-Vega, additional, Rudler, Marika, additional, Bañares, Rafael, additional, Alvarado, Edilmar, additional, Trebicka, Jonel, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Torres, Ferran, additional, Bosch, Jaime, additional, Carlos, Garcia Pagan Juan, additional, and Albillos, Agustin, additional

Published
2019
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37. PS-017-Long-term impact of sustained virological response on systemic and pulmonary hemodynamics in HCV-cirrhotic patients with portal hypertension

Author

Lens, Sabela, primary, Alvarado, Edilmar, additional, Blanco, Isabel, additional, Mariño, Zoe, additional, Orizaga, Tanya, additional, Ibañez, Luis, additional, Fortea, Jose Ignacio, additional, Torras, Xavier, additional, Baiges, Anna, additional, Turon, Fanny, additional, Hernandez-Gea, Virginia, additional, Bañares, Rafael, additional, Puente, Angela, additional, Bosch, Jaume, additional, Barbera, Joan Albert, additional, Villanueva, Candid, additional, Forns, Xavier, additional, and Carlos, Garcia Pagan Juan, additional

Published
2019
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38. PS-023-Factors predicting survival in patients with high-risk acute variceal bleeding treated with pre-emptive (Early)-TIPS

Author

Angrisani, Debora, primary, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Caca, Karel, additional, Giraldez-Gallego, Alvaro, additional, Amitrano, Lucio, additional, Guardascione, Maria Anna, additional, Villanueva, Candid, additional, Alvarado, Edilmar, additional, Thabut, Dominique, additional, Rudler, Marika, additional, Ibañez, Luis, additional, Bañares, Rafael, additional, Catalina, María-Vega, additional, Turon, Fanny, additional, Albillos, Agustin, additional, Martinez, Javier, additional, Genesca, Joan, additional, Sosa, Irene Conejo, additional, Baiges, Anna, additional, christophe, Bureau, additional, Vinel, Jean Pierre, additional, Robic, Marie-Angele, additional, Sauerbruch, Tilman, additional, TREBICKA, Jonel, additional, Appenrodt, Beate, additional, Jansen, Christian, additional, Llop, Elba, additional, Calleja Panero, José Luis, additional, Laleman, Wim, additional, Nevens, Frederik, additional, Palazon, Jose María, additional, Castellote, José, additional, Rodrigues, Susana G., additional, Gluud, Lise Lotte, additional, Ferreira, Carlos Noronha, additional, Cañete, Nuria, additional, Tantau, Marcel, additional, Magaz, Marta, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez-Guerra, Manuel, additional, Ferrusquia, José, additional, Mössner, Joachim, additional, Sassatelli, Romanno, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, ABRALDES, Juan G, additional, Gomez, Manuel Romero, additional, Zipprich, Alexander, additional, Luca, Angelo, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Casanovas, Georgina, additional, Torres, Ferran, additional, Krag, Aleksander, additional, Bosch, Jaime, additional, Monescillo, Alberto, additional, and GARCIA-PAGAN, Juan-Carlos, additional

Published
2019
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39. PS-022-Optimal timing of endoscopy is associated with lower 42-day mortality in variceal bleeding

Author

Laursen, Stig Borbjerg, primary, Stanley, Adrian, additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez-Samaniego, Luis, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jm, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L, additional, Ferreira, Carlos Noronha, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell’Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Robic, Marie Angele, additional, Conejo, Irene, additional, Catalina, Maria-Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, Garcia-Pagán, Juan Carlos, additional, and Krag, Aleksander, additional

Published
2019
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41. Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study

Author

Hernández‐Gea, Virginia, primary, Procopet, Bogdan, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez‐Samaniego, Luis, additional, Silva‐Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose Maria, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L., additional, Noronha Ferreira, Carlos, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernández‐Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G., additional, Romero‐Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Robic, Marie Angèle, additional, Conejo, Irene, additional, Catalina, Maria‐Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, and Garcia‐Pagán, Juan Carlos, additional

Published
2018
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43. Ascitic fluid regulates the local innate immune response of patients with cirrhosis

Author

Nieto, Juan C, primary, Perea, Lídia, additional, Soriano, Germán, additional, Zamora, Carlos, additional, Cantó, Elisabet, additional, Medina, Aina, additional, Poca, Maria, additional, Sanchez, Elisabet, additional, Roman, Eva, additional, Julià, Germà, additional, Navarro, Ferran, additional, Gely, Cristina, additional, Alvarado, Edilmar A, additional, Guarner, Carlos, additional, Juarez, Cándido, additional, and Vidal, Sílvia, additional

Published
2018
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46. AS103 - Early-tips should be performed in high-risk cirrhotic patients despite the presence of hepatic encephalopathy at admission

Author

Rudler, Marika, Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez-Gallego, Alvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genesca, Joan, Bureau, Christophe, Jonel, Trebicka, Llop, Elba, Laleman, Wim, Palazon, Jose María, Alonso, José Castellote, Rodrigues, Susana G., Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Ferlitsch, Prof. Dr. Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romanno, Dell’Era, Alessandra, Abraldes, Juan G., Barcelo, Rafael, Senzolo, Marco, Gomez, Manuel Romero, Zipprich, Alexander, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Torres, Ferran, Nevens, Frederik, Calleja Panero, José Luis, Casanovas, Georgina, Jansen, Christian, Albillos, Agustin, Maria, Guardascione, Alvarado, Edilmar, Casas, Meritxell, Robic, Marie-Angèle, Catalina, María-Vega, Sosa, Irene Conejo, Maxime, Mallet, Simona, Tripon, Bosch, Jaime, Garcia Pagan, Juan Carlos, and Thabut, Dominique

Published
2020
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47. AS088 - Natural history of polycytemia vera and essential thrombocythemia presenting with splanchnic vein thrombosis

Author

Magaz, Marta, Álvarez-Larrán, Alberto, Pereira, Arturo, Turon, Fanny, Hernández-Boluda, Juan Carlos, Alvarado, Edilmar, de Riba, Bea, Alvarez-Navascues, Mari Carmen, Luis, Tellez, Puente, Angela, Fortea, Jose Ignacio, Diaz, Raquel, Romero-Gutiérrez, Marta, González-Alayón, Carlos, Llop, Elba, Ferreira, Carlos Noronha, Ferrusquia, José, Baiges, Anna, Calleja Panero, José Luis, Crespo, Javier, Albillos, Agustin, Bañares, Rafael, Villanueva, Candid, Hernandez-Gea, Virginia, Cervantes, Francisco, and Garcia Pagan, Juan Carlos

Published
2020
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48. Survival of patients with cirrhosis and acute peptic ulcer bleeding compared with variceal bleeding using current first‐line therapies

Author

Ardevol, Alba, primary, Ibañez‐Sanz, Gemma, additional, Profitos, Joaquim, additional, Aracil, Carles, additional, Castellvi, Josep M., additional, Alvarado, Edilmar, additional, Cachero, Alba, additional, Horta, Diana, additional, Miñana, Josep, additional, Gomez‐Pastrana, Bárbara, additional, Pavel, Oana, additional, Dueñas, Eva, additional, Casas, Meritxell, additional, Planella, Montserrat, additional, Castellote, Jose, additional, and Villanueva, Candid, additional

Published
2018
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49. A randomized trial to assess whether portal pressure guided therapy to prevent variceal rebleeding improves survival in cirrhosis

Author

Villanueva, Càndid, primary, Graupera, Isabel, additional, Aracil, Carles, additional, Alvarado, Edilmar, additional, Miñana, Josep, additional, Puente, Ángela, additional, Hernandez‐Gea, Virginia, additional, Ardevol, Alba, additional, Pavel, Oana, additional, Colomo, Alan, additional, Concepción, Mar, additional, Poca, María, additional, Torras, Xavier, additional, Reñe, Josep M., additional, and Guarner, Carlos, additional

Published
2017
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50. Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

Author

Abraldes, Juan G., primary, Villanueva, Candid, additional, Aracil, Carles, additional, Turnes, Juan, additional, Hernandez-Guerra, Manuel, additional, Genesca, Joan, additional, Rodriguez, Manuel, additional, Castellote, Jose, additional, García-Pagán, Juan Carlos, additional, Torres, Ferran, additional, Calleja, Jose Luis, additional, Albillos, Agustin, additional, Bosch, Jaime, additional, Augustin, Salvador, additional, Llop, Elba, additional, Arraez, Dalia Morales, additional, Hernández Mesa, Goretti, additional, Martinez, Javier, additional, Reverter, Enric, additional, Seijo, Susana, additional, Turon, Fanny, additional, Miñana, Josep, additional, Buenestado, Juan, additional, Reñe, Josep M., additional, Navacués, Carmen A., additional, Planas, Ramon, additional, Morillas, Rosa M., additional, Bellot, Pau, additional, Such, Jose, additional, Vergara, Mercedes, additional, Puente, Angela, additional, de la Pena, Joaquin, additional, Mera Calviño, José, additional, Rivas Moral, Laura, additional, Pavel, Oana, additional, Alvarado, Edilmar, additional, Ardevol, Alba, additional, Girbau, Anna, additional, Cachero, Alba, additional, Arnaiz, Joan Albert, additional, Berzigotti, Annalisa, additional, Pich, Judit, additional, Rios, Jose, additional, Saenz, Rosa, additional, Millan, Laura, additional, Beleta, Helena, additional, and Ramos, Núria, additional

Published
2016
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