104 results on '"Alper Şener"'
Search Results
2. In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey
- Author
-
Figen Sarıgül Yıldırım, Ülkü Üser, Nagehan Didem Sarı, Behice Kurtaran, Yusuf Önlen, Ebubekir Şenateş, Alper Gündüz, Esra Zerdali, Hasan Karsen, Ayşe Batırel, Rıdvan Karaali, Rahmet Güner, Tansu Yamazhan, Şükran Köse, Nurettin Erben, Nevin İnce, İftihar Köksal, Nefise Çuvalcı Öztoprak, Gülşen Yörük, Süheyla Kömür, Tayibe Bal, Sibel Kaya, İlkay Bozkurt, Özgür Günal, İlknur Esen Yıldız, Dilara İnan, Şener Barut, Mustafa Namıduru, Selma Tosun, Kamuran Türker, Alper Şener, Kenan Hızel, Nurcan Baykam, Fazilet Duygu, Hürrem Bodur, Güray Can, Hanefi Cem Gül, Ayşe Sağmak Tartar, Güven Çelebi, Mahmut Sünnetçioğlu, Oğuz Karabay, Hayat Kumbasar Karaosmanoğlu, Fatma Sırmatel, and Fehmi Tabak
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2022
- Full Text
- View/download PDF
3. Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey
- Author
-
Yusuf Önlen, Tayibe Bal, Mehmet Çabalak, Nefise Çuvalcı Öztoprak, Nagehan Didem Sarı, Behice Kurtaran, Ebubekir Şenateş, Alper Gündüz, Esra Zerdali, Hasan Karsen, Ayşe Batırel, Rıdvan Karaali, Rahmet Güner, Tansu Yamazhan, Şükran Köse, Nurettin Erben, Nevin İnce, İftihar Köksal, Figen Sarıgül Yıldırım, Gülşen Yörük, Süheyla Kömür, Sibel Kaya, Şaban Esen, Özgür Günal, İlknur Esen Yıldız, Dilara İnan, Şener Barut, Mustafa Namıduru, Selma Tosun, Kamuran Türker, Alper Şener, Kenan Hızel, Nurcan Baykam, Fazilet Duygu, Esragül Akıncı, Güray Can, Ülkü User, Hanefi Cem Gül, Ayhan Akbulut, Güven Çelebi, Mahmut Sünnetçioğlu, Oğuz Karabay, Hayat Kumbasar Karaosmanoğlu, Fatma Sırmatel, and Fehmi Tabak
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2022
- Full Text
- View/download PDF
4. An Insidious Clinical Picture: Optic Nerve Involvement in Patients with COVID-19
- Author
-
Özgül Ocak, Erkan Melih Şahin, Alper Şener, and Barış Ocak
- Subjects
covid-19 virus infection ,optic nerve ,vep ,Medicine ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: Many neurological symptoms due to central nervous system, peripheral nervous system and musculoskeletal system damage have been reported in more than a third of patients with coronavirus disease-2019 (COVID-19). Although optic neuritis has been reported in patients with COVID-19, they are extremely rare. The aim of this study was screening optic nerve involvement in COVID-19 with visual evoked potential (VEP) in asymptomatic patients without a history of visual impairment. Materials and Methods: Pattern reversal VEP measurements were made in 101 adult patients with COVID-19 without a history of visual impairment after they completed COVID-19 treatments and the quarantine period. VEPs were recorded with the 4-channel electromyography-evoked device in a dark room. P100 latencies and amplitudes were analyzed by the same neurologist. Results: A total of 34 (33.7%) patients had P100 latency prolongation. There was no significant difference in terms of gender, age or outpatient/inpatient treatment status. There was no significant correlation between the time of polymerase chain reaction diagnosis and VEP values. Conclusion: Contrary to previous studies, asymptomatic optic nerve involvement after COVID-19 was detected by VEP measurements. Prolongation of P100 latency shows the probable linkage between COVID-19 virus and angiotensin converting enzyme 2 receptors in human eyes.
- Published
- 2022
- Full Text
- View/download PDF
5. Predictive Value of Routine Laboratory Parameters in Hospitalized COVID-19 Patients on Severity of Illness
- Author
-
Havva Yasemin Çinpolat, Buse Yüksel, Ebru Doğan, Alper Şener, Cihan Yüksel, and Sevil Alkan
- Subjects
covid-19 ,biochemical parameters ,disease’s severity ,biyokimyasal parametreler ,hastalık şiddeti ,Medicine - Abstract
Aim: Early prediction of Coronavirus disease 2019 (COVID-19) disease severity is important to reduce mortality. Therefore, we sought to determine the clinical correlation between these baseline routine laboratory parameters and their effects on mortality, by retrospectively investigating the routine laboratory parameters of hospitalized COVID-19 patients on admission day. Materials and methods: This retrospective-observational study population consisted of 415 hospitalized COVID-19 patients. Patients were divided into three groups (mild, moderate, and severe) according to their clinical status on admission day. On admission, fifteen routine biochemical and hematological laboratory parameters of COVID-19 patients were evaluated. Results: Aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), ferritin, International Normalized Ratio (INR), and d-dimer levels were higher in non-survivors than in survivors, regardless of the initial disease severity group classification. No statistically significant difference was found between the groups in terms of uric acid, monocyte, and platelet count.s Conclusions: There is a need for an urgent scale for detecting COVID-19 severity. AST, ALT, LDH, ferritin, INR, and d-dimer levels may help predict the disease’s severity in COVID-19.
- Published
- 2022
- Full Text
- View/download PDF
6. Comparisons of treatment protocols for SARS-COV-2 in early pandemic: Single center experience ın Turkey
- Author
-
Tuncer Şimşek, Taylan Önder, Buse Yüksel, Adil Uğur Çetin, Uğur Gönlügür, Ebru Doğan, Alper Şener, and Sevil Alkan
- Subjects
covid-19 ,favipiravir ,hydroxychloroquine ,azithromycin ,antibiotics ,hidroksiklorokin ,azitromisin ,antibiyotikler ,Medicine - Abstract
Objective: In this retrospective observational study, we aimed to investigate the COVID 19 treatment protocols applied in our hospital in terms of side effects and 28-day mortality. Methods: All 621 patients diagnosed as COVID-19 and treated with any drugs were included in the study. Inclusion criteria for patients were hospitalization with COVID-19 diagnosis and being over 18 years old. The patients were divided into 4 groups according to the treatments against COVID-19: Group 1 (only favipiravir), Group 2 (hydroxychloroquine (HQ)+ Azithromycin (AZ), Group 3 (only HQ), and Group 4 (HCQ+AZ +antibiotics). The gender, age, medications, underlying comorbidities, possible side effects due to the treatments (cardiotoxicity, hepatotoxicity, nephrotoxicity), and mortality rates were evaluated. Results: There was no difference in terms of side effects between treatment groups. Mortality rates were lowest in the HQ+AZ group. HCQ+AZ treatment was the most effective treatment protocol. Conclusion: It can be concluded from the study that the higher mortality rate due to favipiravir may be due to the administration of this drug only to critically ill patients during the initial period of the pandemic.
- Published
- 2022
- Full Text
- View/download PDF
7. Hydatid Cyst of the Spine: A Rare Case Report
- Author
-
Sevil Alkan Çeviker, Cihan Yüksel, Alper Şener, Taylan Önder, Mehmet Hüseyin Metineren, Çisil Özel, and Ömer Serdar Akgül
- Subjects
spinal hydatid cyst ,hydatidosis ,echinococcosis ,paraplegia ,albendazole ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Hydatid cyst is a zoonotic disease that can affect multiple organs and is difficult to diagnose and treat. Spinal hydatid cyst (SHC) is a rare hydatid cyst involvement observed in 1% of all cases. It can induce various neurological symptoms depending on the region of the involvement. Paraplegia is one of the most prevalent neurological symptoms. In this case report, a 63-year-old male patient with bilateral lower extremity paraplegia was operated on by neurosurgery and diagnosed with SHC at the level of Th 11 vertebra in the pathological examination of surgically removed materials. Thus, we aimed to emphasize the significance of pathological and microbiological examination in the differential diagnosis of spinal disorders.
- Published
- 2022
- Full Text
- View/download PDF
8. Retrospective Analysis of COVID-19 Vaccination in a University Hospital and the Relationship with the Epidemic Rate
- Author
-
Işıl Deniz Alıravcı, Fatma Gümüşer, and Alper Şener
- Subjects
adult ,epidemiology ,vaccine ,Medicine - Abstract
It was aimed to make a retrospective analysis of the vaccines administered in the vaccine unit of our hospital since the beginning of the COVID-19 pandemic. The study was carried out retrospectively from the vaccination records our hospital, 14 January 2021 to 01 July 2022. In the 18-month period, a total of 75079 (100%) vaccines were administered, 59386 (79%) were Biontech and 15693 (21%) were Sinovac vaccines. Only Sinovac was available until June, therefore, 66% of the Sinovac vaccines were administered in the first five months period. After the Biontech vaccine started to be applied in our hospital, the rates of Sinovac vaccination have declined drastically. When the epidemic and vaccination graphs were examined separately, inverse correlation was found between the peak points of the epidemic and vaccine graphics. Biontech was found to be the most preferred vaccine by individuals against COVID-19 in this study.
- Published
- 2022
- Full Text
- View/download PDF
9. Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?
- Author
-
Sevil Alkan, Alper Şener, Ebru Doğan, Cihan Yüksel, and Buse Yüksel
- Subjects
covid-19 ,anticoagulants ,anti-inflammatory agents ,Medicine - Abstract
Objectives: COVID-19 associated coagulopathy and prophylactic anticoagulant therapy (PAT) are ongoing topics globally. Using PAT for anti-inflammatory effect may prevent thromboembolic events (TEEs). The objective of this study was to determine the anti-inflammatory effects of PAT in hospitalized COVID-19 patients. Methods: We conducted a retrospective observational study in a tertiary pandemic hospital. Patients were divided into two categories according to their PAT therapy status (PAT (+) and PAT (-)) and into three categories according to clinical features (mild: group 1; moderate: group: 2; and severe: group 3). We then evaluated laboratory parameters and clinical courses. Results: We included 662 hospitalized COVID-19 patients in this study. Enoxaparin sodium was given to all patients as PAT therapy. TEE was developed in five patients in the PAT (+) group. Pulmonary embolism developed in 3/5 patients and deep venous thrombosis in 2/5 patients. Disseminated intravascular coagulation (DIC) was detected in 54 patients in group 3. No statistically significant difference was found in 28-day mortality, development of DIC rates, intubation rates, and TEEs. Conclusions: The use of PAT in critically ill patients was not effective in reducing C-reactive protein, which is one of the biomarkers of inflammation.
- Published
- 2022
- Full Text
- View/download PDF
10. Relationship between in-hospital mortality and inflammation markers in COVID-19 patients with the diagnosis of coronary artery disease
- Author
-
Uğur Küçük, Sevil Alkan Çeviker, and Alper Şener
- Subjects
covid-19 ,ölüm ,koroner arter hastalığı ,mortality ,coronary artery disease ,Medicine - Abstract
Introduction: Inflammation plays an important role in the basis of coronary artery diseases and their adverse outcomes. Neutrophil-lymphocyte ratio (NLR), Systemic Immune Inflammation Index (SII) and C-reactive protein (CRP) are simple and useful markers that reflect the inflammatory state. Our study evaluated the usability of these markers in predicting in-hospital mortality in patients with COVID-19 with the diagnosis of coronary artery disease. Material and Method: Our study population consisted of 111 (48 male, 63 female) newly diagnosed patients with COVID-19. Neutrophil-lymphocyte ratio (NLR) was estimated using neutrophil (N), and lymphocyte (L) counts and the systemic immune inflammation index SII (NxP / L) was calculated using N, L and platelet (P) values. The relationship of NLR, SII and CRP values with in-hospital mortality was investigated. Results: During the treatment process, 16 patients exited. Any statistically significant intergroup difference was not observed as for SII and NLR values obtained by their use in combination (p = 0.872, p = 0.979, respectively), CRP values were statistically significant in the group with in-hospital mortality (p lt;0.001). In logistic regression analysis, CRP (odds ratio [OR] = 1.078, 95% confidence interval [CI]: 1.0225-1.133, p = 0.003) was associated with in-hospital mortality. In ROC analysis, the cut-off values of 3.1 mg / dL, for CRP were significant with 87% sensitivity and 58% specificity in predicting in-hospital mortality (p lt;0.001). Conclusions: CRP levels are associated with in-hospital mortality in patients with COVID-19 who had also received coronary artery disease with a history of coronary intervention.
- Published
- 2021
- Full Text
- View/download PDF
11. A snapshot of geriatric infections in Turkey: ratio of geriatric inpatients in hospitals and evaluation of their infectious diseases: A multicenter point prevalence study
- Author
-
Behice Kurtaran, Ferit Kuscu, Pinar Korkmaz, Burcu Ozdemir, Dilara Inan, Nefise Oztoprak, Duru Mistanoglu Ozatag, Ozgur Daglı, Serhat Birengel, Kevser Ozdemir, Hande Aslaner, Aslıhan Ulu, Emine Sehmen, Serpil Erol, Yeşim Uygun Kızmaz, Gül Durmuş, M Emirhan Işık, Aslı Haykır Solay, Suheyla Komur, Emel Azak, İlknur Yavuz, Ergenekon Karagöz, Merve Sefa Sayar, Hasan Naz, Zehra Demirbaş, Nevin İnce, Fatime Korkmaz, Şule Özdemir Armağan, Ümit Savaşçı, Sabahat Aktaş, Elif Tükenmez Tigen, Buket Ertürk Şengel, Nur Cancan Gürsul, Ali Acar, Sema Sarı, Sema Turan, Uğur Kostakoğlu, Güliz Evik, Kader Arslan, Esra Kaya Kılıç, Aynur Atilla, Canan Ağalar, Selma Ateş, Kenan Uğurlu, Mustafa Doğan, Funda Bilman, Nirgül Kılıçaslan, Gülay Oktay, Nilsun Altunal, Yasemin Balkan, Mevliye Yetik, Serhat Uysal, A İrfan Baran, Nurettin Erben, Hande Aydemir, B Ergüt Sezer, Abdulkadir Daldal, Ayten Kadanalı, Ayşe Sağmak Tartar, Alper Şener, Rezan Harman, M Reşat Ceylan, Hatice Ürgüdücü, İlyas Dökmetaş, Ahmet Hamidi, A Altunçekiç Yıldırım, Sedat Kaygusuz, Esmeray Mutlu Yılmaz, Şaban Esen, Selçuk Nazik, Filiz Koç, Hale Turan Özden, Aslıhan Demirel, Yeşim Kürekçi, Haluk Erdoğan, Emine Fırat Göktaş, Mehmet Uluğ, Hülya Kuşoğlu, Ramazan Gözüküçük, Habibe Tülin Elmaslar Mert, İlknur Erdem, Hüseyin Şahintürk, Işıl Deniz Aliravcı, Rıdvan Kara Ali, Funda Koçak, İE Yıldız, Emel Aslan, Fatma Yılmaz Karadağ, A Seza Inal, and Yesim Tasova
- Subjects
Geriatrics ,Hospitalization ,Infection ,Antibiotic ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: The human population is aging at an astonishing rate. The aim of this study is to capture a situation snapshot revealing the proportion of individuals aged 65 years and over among inpatients in healthcare institutions in Turkey and the prevalence and type of infections in this patient group in order to draw a road map. Materials and Methods: Hospitalized patients over 65 years at any of the 62 hospitals in 29 cities across Turkey on February 9, 2017 were included in the study. Web-based SurveyMonkey was used for data recording and evaluation system. Results: Of 17,351 patients 5871 (33.8%) were ≥65 years old. The mean age was 75.1 ± 7.2 years; 3075 (52.4%) patients were male. Infection was reason for admission for 1556 (26.5%) patients. Pneumonia was the most common infection. The median length of hospital stay was 5 days (IQR: 2–11 days). The Antibiotic therapy was initiated for 2917 (49.7%) patients at the time of admission, and 23% of the antibiotics prescribed were inappropriate. Healthcare-associated infections developed in 1059 (18%) patients. Urinary catheters were placed in 2388 (40.7%) patients with 7.5% invalid indication. Conclusion: This study used real data to reveal the proportion of elderly patients in hospital admissions. The interventions done, infections developed during hospitalization, length of hospital stay, and excessive drug load emphasize the significant impact on health costs and illustrate the importance of preventive medicine in this group of patients.
- Published
- 2020
- Full Text
- View/download PDF
12. NS5A resistance – associated substitutions in chronic hepatitis C patients with direct acting antiviral treatment failure in Turkey
- Author
-
Murat Sayan, Figen Sarıgül Yıldırım, Sıla Akhan, Arzu Altunçekiç Yıldırım, Göktuğ Şirin, Mehmet Cabalak, Mehmet Demir, Selver Can, Gülden Ersöz, Engin Altıntaş, Fatih Ensaroğlu, Ayhan Akbulut, Alper Şener, and Aydın Deveci
- Subjects
Hepatitis C ,Hepatitis C virus ,NS-5 protein ,Treatment failure ,Sequence analysis ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: Chronic hepatitis C (CHC) is now a more curable disease with new direct acting antivirals (DAA). Although high sustained virologic response rates, failures still occur in DAA regimens. Our objective in this study was to characterize the real-life presence of clinically relevant resistance – associated substitutions (RASs) in the HCV NS5A gene in CHC patients whose DAA regimen has failed. Methods: The study enrolled 53 CHC patients who experienced failure with DAA regimen as the prospective longitudinal cohort between 2017–2019. Genotypic resistance testing was performed via the viral population sequencing method and The Geno2pheno HCV tool was used for RAS analysis. Results: The most frequent failure category was relapse (88%) followed by non-responder (12%). For a total of 36% of patients, RASs was detected in NS5A, Y93H was the most detected RAS in GT1b infected patients (89%). Conclusions: This study establishes an HCV failure registry for Turkey in which samples were combined with clinical, virologic and molecular data of adult patients whose DAA therapy failed. RASs can occur in CHC patients with DAA treatment failures. Evaluation of RAS after DAA failure is very important before re-treatment is initiated to prevent virologic failure.
- Published
- 2020
- Full Text
- View/download PDF
13. Molecular Identification of HIV-1 in the Presence of Hepatitis B Virus and Hepatitis C Virus Co-infections
- Author
-
Müge Özgüler, Figen Sarıgül Yıldırım, Taner Yıldırmak, Alper Gündüz, Başak Dokuzoğuz, Mustafa Kemal Çelen, Dilara İnan, Yasemin Heper, Gülden Ersöz, İlkay Karaoğlan, Nurgül Ceran, Aydın Deveci, Servet Öztürk, Selda Sayın Kutlu, Hülya Özkan Özdemir, Ayhan Akbulut, Saadet Yazıcı, Alper Şener, Atahan Çağatay, and Serhat Ünal
- Subjects
co-infection ,hepatitis b virus ,hepatitis c virus ,hiv-1 ,molecular epidemiology ,Medicine - Abstract
Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency virus were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Anti-human immunodeficiency virus positive patients with HBsAg and/or anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-1 infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative.
- Published
- 2020
- Full Text
- View/download PDF
14. Update on the First Year of COVID-19
- Author
-
Elmas Pınar KAHRAMAN KILBAŞ, Mustafa ALTINDİŞ, Kaan YILANCIOĞLU, İshak Özel TEKİN, Duran BURAN, Seçil ÖZKAN, Alper ŞENER, and Mustafa Necmi İLHAN
- Subjects
covid-19 ,sars‐cov‐2 ,pandemic ,vaccine ,prevention ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
The current outbreak of the Coronavirus, severe acute respiratory syndrome Coronavirus-2, which originated in the Wuhan province of the People’s Republic of China became a pandemic. Although the clinical findings of the infection vary in adults, the most common symptoms are fever, dry cough, and shortness of breath. The diagnosis of the Coronavirus disease-2019 (COVID-19) is made by clinical symptoms, laboratory tests, and radiological methods. Many drugs such as antivirals, antibiotics, and corticosteroids are used in the treatment of COVID-19. For the successful control of the pandemic, prevention strategies are the key. There is strong consensus that, in addition to wearing masks, hand hygiene, and social distancing, an effective COVID-19 vaccine is probably the most effective approach to sustainably control the pandemic. In this article, current information about the pathogenesis, epidemiology, risk groups, diagnosis, treatment, prevention strategies, and vaccination of the disease in the first year of the COVID-19 pandemic are discussed.
- Published
- 2021
- Full Text
- View/download PDF
15. Q Fever in the Differential Diagnosis of COVID 19 Infection
- Author
-
Sevil Alkan, Alper Şener, Safiye Bilge Güçlü Kayta, and Anıl Akça
- Subjects
q fever ,coxiella burnetii ,covid 19 ,Medicine - Abstract
Coxiella burnetii is an intracellular, Gram-negative bacteria and is the causative agent of Q fever, a zoonosis first described in Australia in 1937. It can cause endemics around the world. People usually get the disease by inhaling the contaminated aerosol produced by infected livestock. Contaminated milk, intradermal inoculation, sexual contact, blood transfusion, and transplacental route may also occur. The infective dose for humans is 1-10 bacteria. It is resistant to environmental conditions and can remain alive in animal wastes such as dust and fertilizer. Acute infection is typically asymptomatic or may manifest as a febrile flu-like illness, pneumonia, hepatitis, and central nervous system (CNS) infection. Q fever outbreaks are often caused by occupational exposure that includes shepherds, animal keepers, veterinarians, slaughterhouses or dairy workers, and laboratory personnel working with C. burnetii. During the course of the disease that cannot be distinguished from other pneumonia clinically; 2-10 fold increase in liver function tests, leukocytosis and thrombocytopenia, erythrocyte sedimentation rate and creatine kinase increase may be observed or laboratory findings may be normal. An immunofluorescent antibody (IFA) test, which is a serological reference method, should be requested from patients suspected for the diagnosis of Q fever.
- Published
- 2021
- Full Text
- View/download PDF
16. Factors Affecting Inadequate Empirical Antimicrobial Therapy and the Clinical Course of Upper Urinary Tract Infections in Elderly Patients: A Multicenter Study
- Author
-
Pınar KORKMAZ, Behice KURTARAN, Şule ÖZDEMİR ARMAĞAN, Hale TURAN ÖZDEN, Fatma KAÇAR, Selma ATEŞ, Gül DURMUŞ, Fulya BAYINDIR BİLMAN, Yeşim UYGUN KIZMAZ, Aziz Ahmad HAMİDİ, Burcu ÖZDEMİR, Aslıhan BURCU YIKILGAN, Pınar FIRAT, Asuman İNAN, Gülay OKAY, Mehmet Emirhan IŞIK, Ayşe BUT, Kenan UĞURLU, Rezan HARMAN, Büşra ERGÜT SEZER, Elif DOYUK KARTAL, Ferit KUŞÇU, Alper ŞENER, Duru MISTANOĞLU ÖZATAĞ, Elif TÜKENMEZ TİGEN, Özgür DAĞLI, Funda KOÇAK, Hülya KUŞOĞLU, Buket ERTÜRK ŞENGEL, Aslıhan DEMİREL, Hasan NAZ, Canan AĞALAR, Derya ÖZTÜRK ENGİN, İlyas DÖKMETAŞ, Nur CANCAN GÜRSUL, Fatma YILMAZ KARADAĞ, Mehmet Umut ÇAYIRÖZ, Yeşim KÜREKÇİ, Ayten KADANALI, Zeynep Şule ÇAKAR, Ümit SAVAŞÇI, İlknur ERDEM, and Sabahat ÇAĞAN AKTAŞ
- Subjects
urinary tract infection ,empirical ,antibiotherapy ,mortality ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: In this study, we aimed to determine the risk factors associated with inadequate empirical antibiotherapy (IEAT) and hospital-related mortality in elderly patients being treated for upper urinary tract infections (UTI). Materials and Methods: This study included individuals aged 65 years and over who were hospitalized after being diagnosed of communityacquired UTI or community-onset healthcare-associated UTI and followed-up in clinics and/or intensive care units (ICU) of 33 hospitals between March and September 2017. Results: A total of 525 patients (48% males; mean age: 76.46±7.93 years) were included in the study. Overall, 68.2% of the patients were hospitalized through the emergency department and 73.9% of patients were followed-up for pyelonephritis. Gram-negative, Gram-positive, and Gram-negative and positive mix growths were determined in 88%, 9.3%, and 2.7% of urine cultures, respectively. Fifty-six (10.7%) of the patients died. In multivariate analysis, the presence of chronic obstructive pulmonary disease [Odds ratio (OR): 2.278], age 85 years and over (OR: 2.816), admission to the ICU (OR: 14.831), and IEAT (OR: 2.364) were independent factors that significantly affected mortality. The presence of a urinary catheter, being followed-up in the ICU, benign prostate hypertrophy, use of antibiotics other than piperacillin-tazobactam and carbapenem were determined as independent factors that significantly affected IEAT (p
- Published
- 2020
- Full Text
- View/download PDF
17. Evaluation of Dual Therapy in Real Life Setting in Treatment-Naïve Turkish Patients with HCV Infection: A Multicenter, Retrospective Study
- Author
-
Yunus Gürbüz, Emin Ediz Tütüncü, Necla Eren Tülek, Sami Kınıklı, Günay Tuncer, Cemal Bulut, Süda Tekin Koruk, Bilgehan Aygen, Neşe Demirtürk, Ali Kaya, Taner Yıldırmak, Kaya Süer, Fatime Korkmaz, Onur Ural, Sıla Akhan, Aynur Aynıoğlu, Elif Sargın Altunok, Özgür Günal, Nazan Tuna, Şükran Köse, İbak Gönen, Bahar Örmen, Nesrin Türker, Neşe Saltoğlu, Ayşe Batırel, Fatma Sırmatel, Asım Ulçay, Ergenekon Karagöz, Derviş Tosun, and Alper Şener
- Subjects
Hepatitis C ,peginterferon alpha-2a ,peginterferon alpha-2b ,ribavirin ,therapy ,Medicine - Abstract
Background: Before the introduction of direct-acting antivirals in the treatment of chronic hepatitis C patients, the combination of peginterferon alpha and ribavirin was the standard therapy. Observational studies that investigated sustained virological response (SVR) rates by these drugs yielded different outcomes. Aims: The goal of the study was to demonstrate real life data concerning SVR rate achieved by peginterferon alpha plus ribavirin in patients who were treatment-naïve. Study Design: A multicenter, retrospective observational study. Methods: The study was conducted retrospectively on 1214 treatment naïve-patients, being treated with peginterferon alpha-2a or 2b plus ribavirin in respect of the current guidelines between 2005 and 2013. The patients’ data were collected from 22 centers via a standard form, which has been prepared for this study. The data included demographic and clinical characteristics (gender, age, body weight, initial Hepatitis C virus RNA (HCV RNA) level, disease staging) as well as course of treatment (duration of treatment, outcomes, discontinuations and adverse events). Renal insufficiency, decompensated liver disease, history of transplantation, immunosuppressive therapy or autoimmune liver disease were exclusion criteria for the study. Treatment efficacy was assessed according to the patient’s demographic characteristics, baseline viral load, genotype, and fibrosis scores. Results: The mean age of the patients was 50.74 (±0.64) years. Most of them were infected with genotype 1 (91.8%). SVR was achieved in 761 (62.7%) patients. SVR rate was 59.1% in genotype 1, 89.4% in genotype 2, 93.8% in genotype 3, and 33.3% in genotype 4 patients. Patients with lower viral load yielded higher SVR (65.8% vs. 58.4%, p=0.09). SVR rates according to histologic severity were found to be 69.3%, 66.3%, 59.9%, 47.3%, and 45.5% in patients with fibrosis stage 0, 1, 2, 3 and 4, respectively. The predictors of SVR were male gender, genotype 2/3, age less than 45 years, low fibrosis stage, low baseline viral load and presence of early virological response. SVR rates to each peginterferon were found to be similar in genotype 1/4 although SVR rates were found to be higher for peginterferon alpha-2b in patients with genotype 2/3. The number of patients who failed to complete treatment due to adverse effects was 33 (2.7%). The number of patients failed to complete treatment due to adverse effects was 33 (2.7%). Conclusion: Our findings showed that the rate of SVR to dual therapy was higher in treatment-naïve Turkish patients than that reported in randomized controlled trials. Also peginterferon alpha-2a and alpha-2b were found to be similar in terms of SVR in genotype 1 patients.
- Published
- 2016
- Full Text
- View/download PDF
18. The Effect of Freezing on the Immunoprofile of Breast Carcinoma Cells
- Author
-
Asuman Argon, Alper Şener, Osman Zekioğlu, Necmettin Özdemir, and Murat Kapkaç
- Subjects
Breast carcinoma ,frozen examination ,HER2 ,immunohistochemistry ,oestrogen ,progesterone ,Medicine - Abstract
Background: Intraoperative frozen section procedure may be required in some operations performed for breast masses. Aims: We investigated the effect of frozen section procedure on the immunoprofile of breast carcinoma cells. Study Design: Cross-sectional study. Methods: A total of 53 breast carcinoma cases evaluated with intraoperative frozen sections were included in this study. Immunohistochemically, oestrogen (ER), progesterone (PR) and HER2 primary antibodies were evaluated in both frozen and non-frozen sections of each tumour sample. Results: No difference was found between the frozen and non-frozen sections in 33 cases in terms of staining rate and intensity of ER, PR and HER2. A decrease was found in the ER, PR and HER2 staining rate (in 10 cases, 9 cases and 6 cases, respectively). Likewise, a decrease was detected in ER, PR and HER2 staining intensity in 6 patients for each. Although there was no staining in frozen sections, immunopositivity was observed in 3 non-frozen sections for ER, in 2 for PR and in 5 for HER2. Statistically, a significant difference was found between the frozen and non-frozen sections in terms of staining rate and intensity for each of the three markers. Conclusion: In this study, the frozen section procedure in breast carcinoma had a negative effect on the immunoprofile. However, considering the importance of hormone receptor status in the treatment, these results should be supported with larger series.
- Published
- 2014
- Full Text
- View/download PDF
19. Cervical Adenoid Basal Carcinoma: A Case Report
- Author
-
Coşan Terek, Osman Zekioğlu, Alper Şener, Asuman Argon, and Necmettin Özdemir
- Subjects
Adenoid basal carcinoma ,HPV ,cervix ,squamous cell carcinoma ,Medicine - Abstract
Adenoid basal carcinoma (ABC) is a rare epithelial tumor of the cervix. It makes up approximately 1% of all cervical adenocarcinomas. Rare cases have been associated with common cervical epithelial tumors. We present a case of ABC associated with typical squamous cell carcinoma. A 54-year-old postmenopausal woman underwent D&C for vaginal bleeding. Histologically, the tumor was characterized by small cells with a narrow cytoplasm, making up islands and cords. Peripheral palissading in the cells surrounding the cystic areas that contained central cellular debris and keratin was noted. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy and omentectomy. Large cell keratinized type squamous cell carcinoma areas in the cervix were noted besides the limited ABC areas. After surgery, the patient was treated with radiation therapy. A retroperitoneal metastasis was found on the first year and chemotherapy was administered. The patient has no evidence of disease 27 months after the first diagnosis. ABC makes up quite a rare group of cervical cancers and should be kept in mind during the evaluation so that a differentiation can be made with tumors with similar morphology as it can show various histological patterns, and can be seen together with more aggressive cancers.
- Published
- 2012
20. INVESTIGATION OF THE EFFECT OF FAVIPIRAVIR TREATMENT ON MORTALITY IN COVID-19 PATIENTS: EARLY PANDEMIC EXPERIENCE
- Author
-
Guclu Kayta Safiye Bilge, Sevil Alkan, Ebru Doğan, Hakan Kartal, and Alper Şener
- Abstract
Introduction: The superiority of favipiravir which is one of the agents used in the treatment of COVID-19, over other treatments is still controversial. With this study, we aimed to show whether there is a difference between the initial or subsequent addition of the drug to the treatment on the treatment success and 28-day mortality in hospitalized patients receiving favipiravir, and to contribute to the literature on this subject. Material and method: PCR-positive patients who were hospitalized in our hospital with the diagnosis of COVID-19 between June 1 and July 1, 2020 were included in the study. The data of the patients were analyzed retrospectively. The patients were divided into 3 groups: those who started treatment with favipiravir, those who added favipiravir to the treatment regimen because there was no response to the first-line treatment, and those who did not receive favipiravir. Results: A total of 662 patients, mean age of 58.38±18.86 years and 59.4% male were included in the study. Mortality developed in 74 people, and the mortality rate was 11.17%. More than 50% involvement was detected in thorax CT in 69% of hospitalized COVID-19 PCR positive patients. The mean age of those who added favipiravir to the treatment was 66.95±15.88 years, which was statistically significantly higher than the group that was not added. Those who received favipiravir from baseline had higher viral clearance rates. In our study, it was found that 17.9% of those who received it from the beginning and 34.0% of those who were added later developed mortality on the 28th day, and there was a statistically significant difference between these groups. Conclusion: Those who received favipiravir from baseline had higher viral clearance rates and lower mortality. It can be concluded that late initiation of favipiravir treatment increases mortality.
- Published
- 2023
21. Comparisons of treatment protocols for SARS-COV-2 in early pandemic: Single center experience ın Turkey
- Author
-
Sevil ALKAN, Taylan ÖNDER, Alper ŞENER, Ebru DOĞAN, Uğur GÖNLÜGÜR, Tuncer ŞİMŞEK, Adil Uğur ÇETİN, and Buse YÜKSEL
- Subjects
Geography, Planning and Development ,Management, Monitoring, Policy and Law - Abstract
Objective: In this retrospective observational study, we aimed to investigate the COVID 19 treatment protocols applied in our hospital in terms of side effects and 28-day mortality. Methods: All 621 patients diagnosed as COVID-19 and treated with any drugs were included in the study. Inclusion criteria for patients were hospitalization with COVID-19 diagnosis and being over 18 years old. The patients were divided into 4 groups according to the treatments against COVID-19: Group 1 (only favipiravir), Group 2 (hydroxychloroquine (HQ)+ Azithromycin (AZ), Group 3 (only HQ), and Group 4 (HCQ+AZ +antibiotics). The gender, age, medications, underlying comorbidities, possible side effects due to the treatments (cardiotoxicity, hepatotoxicity, nephrotoxicity), and mortality rates were evaluated. Results: There was no difference in terms of side effects between treatment groups. Mortality rates were lowest in the HQ+AZ group. HCQ+AZ treatment was the most effective treatment protocol. Conclusion: It can be concluded from the study that the higher mortality rate due to favipiravir may be due to the administration of this drug only to critically ill patients during the initial period of the pandemic.
- Published
- 2022
22. Investigation of COVID-19 Exposure, Risk Category and Subsequent Clinical Picture and Prognosis in Healthcare Professionals: Early Pandemic Experience
- Author
-
Sevil Alkan, Taylan Önder, Alper Şener, and Ebru Apaydin Doğan
- Subjects
Infectious Diseases ,General Earth and Planetary Sciences ,COVID-19,SARS-CoV-2,Kişisel Koruyucu Ekipman,Sağlık Çalışanı ,COVID-19,SARS-CoV-2,personal protective equipment,healthcare workers ,Enfeksiyon Hastalıkları ,General Environmental Science - Abstract
Aim: Healthcare workers are the most risky group in terms of Coronavirus disease 2019 (COVID-19) transmission. The aim of this study was to reveal the relationships related to the departments in which contact healthcare workers work, personal protective equipment (PPE) use status, risk category, clinical picture and prognosis in follow-up.Materials and Methods: Healthcare workers who had contact with COVID-19 cases in our hospital between March 23, 2020 and June 1, 2020 were included in the study. The healthcare workers included in the study were divided into 3 groups according to their main departments and evaluated. In addition, healthcare workers included in the study were divided into groups and evaluated according to PPE use and risk categories, regardless of the departments they work in.Results: A total of 42 healthcare workers were included in the study. The total number of probable cases was determined as 10 (23.8%). None of the 42 individuals were positive for SARS-CoV-2 PCR. It was found that there was no need for hospitalization in any probable case and all of them were removed from follow-up with recovery. Proportionally, the most probable cases were seen in the intensive care unit (42.8%). The highest rate of contact without PPE was seen in the emergency department (87.5%). There were 15 people (35.7%) who used all PPE completely and were not considered as risky contact according to PPE usage situation; However, despite the complete use of PPEs, probable cases were detected in 4 (26.6%) of these 15 people.Conclusion: In centers where COVID-19 patients are cared for, such as our hospital, education should be given to increase compliance with PPE use. In addition, the working conditions of healthcare workers should be regulated in a way to increase compliance with PPE use. Studies involving more healthcare workers are needed for a more detailed understanding of the relationships related to the issues mentioned., Amaç: COVID-19 bulaşı açısından en riskli grup sağlık çalışanlarıdır. Bu çalışma ile temaslı sağlık çalışanlarının çalıştığı birim, KKE kullanım durumu, risk kategorisi, klinik tablo ve takipteki prognoz ile alakalı ilişkilerin ortaya konması amaçlanmıştır.Gereç ve Yöntem: Çalışmaya hastanemizde 23 Mart 2020-1 Haziran 2020 tarihleri arasında COVID-19 vakası ile teması olan sağlık çalışanları dahil edildi. Çalışmaya dahil edilen sağlık çalışanları, çalıştığı ana birimlere göre 3 gruba ayrıldı ve değerlendirildi. Bunun yanında çalışmaya dahil edilen sağlık çalışanları, çalıştığı birimlerden bağımsız olarak KKE kullanım durumu ve risk kategorilerine göre de gruplara ayrıldı ve değerlendirildi.Bulgular: Çalışmaya toplam 42 sağlık çalışanı dahil edildi. Toplam olası vaka sayısı 10 (%23,8) olarak saptandı. 42 kişinin hiçbirinde SARS-CoV-2 PCR pozitifliği saptanmadı. Hiçbir olası vakada hastaneye yatış gereksinimi olmadığı ve hepsinin şifa ile takipten çıkarıldığı saptandı. Oransal olarak en fazla olası vaka yoğun bakım ünitesinde görüldü (%42,8). En yüksek oranda KKE olmadan temas ise acil serviste görüldü (%87,5). Tüm KKE’leri eksiksiz kullanan ve KKE kullanım durumuna göre riskli temaslı olarak değerlendirilmeyen 15 kişi (%35,7) mevcuttu; ancak KKE’lerin eksiksiz kullanılmasına rağmen bu 15 kişinin 4’ünde (%26,6) olası vaka saptandı.Sonuç: Hastanemiz gibi COVID-19 hastalarının bakımının yapıldığı merkezlerde KKE kullanımına yönelik uyumun artırılması için eğitimler verilmesi gerekmektedir. Bunun yanında sağlık çalışanlarının çalışma koşulları KKE kullanımına yönelik uyumu artıracak şekilde düzenlenmelidir. Bahsedilen konular ile alakalı ilişkilerin daha detaylı anlaşılması için daha çok sayıda sağlık çalışanının dahil edildiği çalışmalara ihtiyaç vardır.
- Published
- 2021
23. Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period
- Author
-
Alper Şener, Erdal Mert, Emre Sedar Saygili, Arzu Mirci, and Ersen Karakilic
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Post discharge ,Aftercare ,Cohort Studies ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Hypoglycemic Agents ,Mortality ,Aged ,Retrospective Studies ,Coronavirus disease 2019 ,business.industry ,Proportional hazards model ,Mortality rate ,Preadmission ,General Medicine ,Middle Aged ,medicine.disease ,Metformin ,Patient Discharge ,COVID-19 Drug Treatment ,Treatment ,Diabetes Mellitus, Type 2 ,Propensity score matching ,Female ,Original Article ,business ,medicine.drug ,Kidney disease - Abstract
Background The effect of preadmission metformin usage (PMU) on the mortality of coronavirus disease-2019 (COVID-19) patients with diabetes is conflicting. Most studies have focused on in-hospital mortality; however, mortality after discharge also increases in COVID-19 patients. Aims Examining the effect of PMU on all-cause mortality, including the post-discharge period. Methods Patients with diabetes who were hospitalised in 2020 due to COVID-19 were included in the study. They were divided into two groups: those with a history of metformin use (MF( +)) and those without such history (MF( −)). Propensity score matching (PSM) was performed at a ratio of 1:1 for age and sex. COX regression analyses were used to demonstrate risk factors for mortality. Results We investigated 4103 patients hospitalised for COVID-19. After excluding those without diabetes or with chronic liver/kidney disease, we included the remaining 586 patients, constituting 293 women (50%) with an overall mean age of 66 ± 11.9 years. After PSM analysis, the in-hospital and post-discharge mortality rates were higher in the MF( −) group though not significantly different. However, overall mortality was higher in the MF( −) group (51 (42.5%) vs. 35 (29.2%), p = 0.031). For overall mortality, the adjusted HR was 0.585 (95% CI: 0.371 − 0.920, p = 0.020) in the MF( +) group. Conclusion PMU is associated with reducing all-cause mortality. This effect starts from the in-hospital period and becomes more significant with the post-discharge period. The main limitations were the inability to evaluate the compliance with metformin and the effects of other medications due to retrospective nature.
- Published
- 2021
24. Diyabetik ayak enfeksiyonu olan hastalarda alt ekstremite damar patolojilerinin incelenmesi ve klinik sonuçları
- Author
-
Serpil ŞAHİN, Sevil ALKAN, and Alper ŞENER
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Abstract
Objective: Diabetes and vascular disorders raise the risk of diabetic foot infection and lower extremity amputation. Although DFI risk factors and microbiological analyses have been thoroughly researched, data for this specific group is limited. In this study, it was aimed to examine the underlying vascular risk factors of patients who were followed up and treated with the diagnosis of DFIs and clinical outcomes. Methods: Clinical, demographic, laboratory, microbiological, and foot examination data for 153 patients referred to our center for DFI between 2016 and 2021 were collected retrospectively from hospital information system. Results: The present center collected a total of 153 DFI patients during 5 year this period. There were 86 male and 67 women with a mean age of 67.71±15 years. There was 104 patients in non-vascular induced DFI group and 49 vascular induced DFI group. The top two comorbidities of DFI patients were cardiovascular disease and hypertension respectively. The rate of male patients was statistically higher in the vascular induced DFI group (p=0.003). Also hypertension and cardiovascular disease were more common in the vascular induced DFI group (p=0.0006, p=0.01). History of extremity amputation/debridement, having Wagner grade 5 DFI and Gram negative microorganism growth in tissue cultures were more common in the vascular induced DFI group (p=0.01, p=0.01 and p=0.0006). Extremity amputation/debridement rates were higher in the vascular induced DFI group (p=0.01) Conclusion: DFIs cause increased risk of amputation, prolonged antibiotic therapy, increased hospitalization, and increased healthcare costs as a result of investigations. Awareness of the vascular pathologies underlying DFIs can help clinicians manage the disease. The aim of this study is to emphasize the importance of vascular factors.
- Published
- 2022
25. A case of new-onset refractory status epilepticus (NORSE) due to Herpes Simplex Virus-1 encephalitis
- Author
-
Sevil ALKAN, Taylan ÖNDER, Anıl AKÇA, and Alper ŞENER
- Subjects
Herpes Simplex Virus ,encephalitis ,new-onset refractory status epilepticus ,seizures ,Medicine ,Tıp - Abstract
In the medical literature, the term of "new-onset refractory status epilepticus" (NORSE) is a novel term. Herpes Simplex Virus-1 and other viral infections can be cause to NORSE. Seizures are a rare sign of HSV encephalitis, but they can occur as the first symptom. Herein, we present a case of NORSE triggered by HSV-1 encephalitis, which had been diagnosed via cerebrospinal fluid polymerase chain reaction (PCR) method and magnetic resonance imaging findings.
- Published
- 2022
26. TIP FAKÜLTESİ ÖĞRENCİLERİNİN COVID-19 PANDEMİSİNDE KİŞİSEL KORUYUCU EKİPMAN KULLANIMI KONUSUNDA BİLGİ DÜZEYLERİNİN BELİRLENMESİ
- Author
-
Mustafa Serhat ŞAHİNOĞLU, Sevil ALKAN, Sinem SEFER, Hakan KARTAL, Ömer Faruk AKÇAY, and Alper ŞENER
- Subjects
Mikrobiyoloji ,COVID-19 ,personel koruyucu ekipman ,sağlık bilgisi ,tıp öğrencileri ,tutum ,uygulama ,Microbiology ,attitude ,Health knowledge ,Medical Students ,Personnel protective equipment ,practice - Abstract
COVID-19 salgını, bulaşıcı hastalıkların edinilmesini ve bulaşmasını önlemek için kişisel koruyucu ekipmanın (KKE) gerekli olduğunu ancak kliniklerde doğru kullanımının genellikle düşük oranlarda olduğunu göstermiştir. Bu çalışmanın amacı, tıp fakültesi öğrencilerinin KKE kullanımıyla ilgili deneyimlerini araştırmak, eğitim ve öğretim programlarında iyileştirme fırsatlarını belirlemektir. Araştırma, 01.05.2021-01.11.2021 tarihleri arasında Çanakkale Onsekiz Mart Üniversitesi Tıp Fakültesi öğrencilerinin katılımıyla gerçekleştirilmiştir. Araştırmacılar tarafından ilgili literatür incelenerek geliştirilen, “Katılımcı Bilgi Formu” ve “Kişisel Koruyucu Ekipman Kullanımı Bilgi Değerlendirme Formu” kullanılmıştır. Çalışmaya 257 tıp fakültesi öğrencisi dahil edilmiştir. Katılanların 139’unun (%54) kadın; 103’ünün temel tıp (%40; 1, 2 ve 3. dönem), 154’ünün ise klinik staj (%60; 4, 5 ve 6. dönem) dönemlerinde oldukları gözlenmiştir. Öğrencilerin KKE uygulamaları hakkındaki sorulara verdikleri yanıta göre aldıkları puanlar incelendiğinde; klinik eğitimdeki öğrencilerin aldığı puanın ortancası 5.0, temel tıp eğitimi alan öğrencilerin ise 3.0 bulunmuş ve aradaki farkın istatistiksel olarak anlamlı olduğu görülmüştür (p, The COVID-19 pandemic has shown that personal protective equipment (PPE) is necessary to prevent the acquisition and transmission of infectious diseases, but its correct use in clinics is generally low. The aim of this study is to investigate medical school students' experiences with the use of PPE and to identify opportunities for improvement in education and training programs. The research was carried out with the participation of Çanakkale Onsekiz Mart University Faculty of Medicine students between 01.05.2021 and 01.11.2021. The "Participant Information Form" and the "Personal Protective Equipment Use Information Evaluation Form," developed by the researchers by examining the relevant literature, were used. Two hundred and fifty seven medical faculty students were included in the study. Of the students, 139 (54%) were female, 103 were in basic medicine (40%; Phases 1,2 and 3) and 154 students were in clinical internships (60%; Phases 4,5 and 6). When the scores obtained by the students according to their answers to the questions about PPE practices are examined, the median score of the students in clinical education was 5.0 and the students receiving basic medical education was 3.0, and the difference was statistically significant (p
- Published
- 2022
27. Toplum Kökenli Pnömoni Tanısında İdrar Pnömokok Antijen Testini Kullanmanın Zamanı Geldi mi?
- Author
-
Alper Şener and M. Rıdvan Dumlu
- Published
- 2021
28. Is it not the Time to Use Urine Pneumococal Antigen Test for the Diagnosis of Community-Acquired Pneumonia
- Author
-
M. Rıdvan DUMLU and Alper ŞENER
- Subjects
community-acquired pneumonia ,lcsh:QR1-502 ,lcsh:RC109-216 ,urine pneumococcal antigen test ,streptococcus pneumonia ,lcsh:Microbiology ,lcsh:Infectious and parasitic diseases - Abstract
Introduction: Community-acquired pneumonia (CAP) is an infection and inflammation of the lung parenchyma. Early diagnosis and treatment reduce mortality and morbidity. The most frequently isolated microorganism is Streptococcus pneumoniae in CAP, and conventional culture methods still continue to be the gold standard. Urine pneumococcal antigen test is used to detect soluble pneumococcal antigen. In this study, the point prevalence of CAP was determined in patients admitted to our outpatient clinic, and the rate of pneumonia and the diagnostic success of the urinary pneumococcal antigen test were questioned. Materials and Methods: Patients who were admitted to Canakkale Onsekiz Mart University Faculty of Medicine Infectious Diseases outpatient department between 01.11.2016 and 31.01.2017 were included into the study and diagnosed as CAP according to their clinical, laboratory and radiological findings. Blood and sputum culture, urine pneumococcal antigen tests were studied. In addition, sociodemographic characteristics, comorbidities, clinical complaints, CURB-65 scores of the patients were questioned, and the data were analyzed by using SPSS Package Program 20.0 version. Results: A total of 47 patients were included into the study. Fifty-nine point six percent of the patients were males, and the mean age of the whole group was 69 ± 2 years. The most common complaints of the patients were cough, dyspnea and tachypnea. The most common pulmonary involvement was bilateral multilobar involvement, 45% were hospitalized in the intensive care unit, and the most common comorbid diseases were congestive heart failure and chronic obstructive pulmonary disease. Sputum culture revealed S. pneumoniae in only one patient. Urine antigen test also showed positivity in this one. Urine pneumococcal antigen test was positive in six patients. The point prevalence of CAP in the study group was 0.31%, and the rate of S. pneumoniae was 12.7%. Conclusion: Our study showed that the use of urine pneumococcal antigen test as an auxiliary test in addition to blood and sputum culture increases the identification rate of the agent.
- Published
- 2021
29. Investigation of Tick Bites and Affecting Factors in Ezine District of Çanakkale
- Author
-
Esen Eker, Sibel Oymak, Taylan Önder, Coşkun Bakar, Özgür Özerdoğan, Alper Şener, and Buse Yüksel
- Subjects
Microbiology (medical) ,Veterinary medicine ,Infectious Diseases ,Geography ,biology ,Public Health, Environmental and Occupational Health ,Tick ,biology.organism_classification - Published
- 2021
30. Tularemia Outbreak in Western Part of Turkey; Revenge of 'Mount Ida'
- Author
-
Alper Şener, Safiye Bilge Güçlü Kayta, Taylan Önder, Ebru Apaydin Doğan, Esen Eker, and Sevil Alkan Çeviker
- Subjects
Tularemia ,Geography ,medicine ,Outbreak ,General Medicine ,Ancient history ,medicine.disease ,Mount - Published
- 2021
31. A snapshot of geriatric infections in Turkey: ratio of geriatric inpatients in hospitals and evaluation of their infectious diseases: A multicenter point prevalence study
- Author
-
Ramazan Gözüküçük, Ilyas Dokmetas, Yeşim Taşova, Umit Savasci, Hale Turan Özden, Selma Ateş, Esra Kaya Kılıç, Serhat Birengel, Ali Acar, M Emirhan Işık, Şaban Esen, Fatma Yılmaz Karadağ, Kader Arslan, Rezan Harman, Ahmet Hamidi, Emine Sehmen, Asli Haykir Solay, Ayşe Sağmak Tartar, Sedat Kaygusuz, Funda Kocak, Esmeray Mutlu Yilmaz, Filiz Koc, Ozgur Dagli, Hande Aslaner, Şule Özdemir Armağan, Isil Deniz Aliravci, Serpil Erol, Duru Mıstanoğlu Özatağ, Behice Kurtaran, Canan Agalar, Ilknur Esen Yildiz, Mustafa Dogan, Merve Sefa Sayar, Yeşim Kürekçi, Rıdvan Kara Ali, Ilknur Erdem, Zehra Demirbaş, Yasemin Balkan, Fatime Korkmaz, Funda Bilman, Yesim Uygun Kizmaz, Nur Cancan Gürsul, Hüseyin Şahintürk, Emine Fırat Göktaş, Nefise Oztoprak, Pinar Korkmaz, Hande Aydemir, Aynur Atilla, A İrfan Baran, Nevin Ince, Hülya Kuşoğlu, Sabahat Çağan Aktaş, Ilknur Yavuz, Nilsun Altunal, Abdulkadir Daldal, Ferit Kuşcu, Aslıhan Demirel, Serhat Uysal, Mehmet Ulug, Buket Erturk Sengel, Güliz Evik, Dilara Inan, Gülay Okay, Aslihan Ulu, Nurettin Erben, Selçuk Nazik, A Altunçekiç Yıldırım, Sema Turan, M Reşat Ceylan, Haluk Erdoğan, Hatice Ürgüdücü, Hasan Naz, Kevser Ozdemir, Nirgül Kılıçaslan, Elif Tukenmez Tigen, Süheyla Kömür, Gül Durmuş, Uğur Kostakoğlu, Ayten Kadanali, B Ergüt Sezer, Habibe Tülin Elmaslar Mert, Emel Aslan, Ergenekon Karagoz, Alper Şener, Burcu Ozdemir, Emel Azak, Mevliye Yetik, Kenan Ugurlu, Sema Sarı, A Seza Inal, and OKAY, GÜLAY
- Subjects
Male ,0301 basic medicine ,Turkey ,healthcare associated infection ,very elderly ,Antibiotics ,Psychological intervention ,Prevalence ,Turkey (republic) ,0302 clinical medicine ,Health care ,antibiotic therapy ,antibiotic agent ,030212 general & internal medicine ,Aged, 80 and over ,Geriatrics ,education.field_of_study ,inappropriate prescribing ,General Medicine ,Hospitals ,Hospitalization ,aged ,hospital patient ,Infectious Diseases ,female ,multicenter study (topic) ,Female ,Infection ,Microbiology (medical) ,medicine.medical_specialty ,medicine.drug_class ,Urinary system ,030106 microbiology ,Population ,prevalence ,Infections ,Communicable Diseases ,Article ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,length of stay ,male ,medicine ,Humans ,pneumonia ,lcsh:RC109-216 ,human ,education ,Aged ,Preventive healthcare ,Inpatients ,business.industry ,Antibiotic ,Length of Stay ,major clinical study ,infection ,Emergency medicine ,geriatric disorder ,business - Abstract
Introduction The human population is aging at an astonishing rate. The aim of this study is to capture a situation snapshot revealing the proportion of individuals aged 65 years and over among inpatients in healthcare institutions in Turkey and the prevalence and type of infections in this patient group in order to draw a road map. Materials and Methods Hospitalized patients over 65 years at any of the 62 hospitals in 29 cities across Turkey on February 9, 2017 were included in the study. Web-based SurveyMonkey was used for data recording and evaluation system. Results Of 17,351 patients 5871 (33.8%) were ≥65 years old. The mean age was 75.1 ± 7.2 years; 3075 (52.4%) patients were male. Infection was reason for admission for 1556 (26.5%) patients. Pneumonia was the most common infection. The median length of hospital stay was 5 days (IQR: 2–11 days). The Antibiotic therapy was initiated for 2917 (49.7%) patients at the time of admission, and 23% of the antibiotics prescribed were inappropriate. Healthcare-associated infections developed in 1059 (18%) patients. Urinary catheters were placed in 2388 (40.7%) patients with 7.5% invalid indication. Conclusion This study used real data to reveal the proportion of elderly patients in hospital admissions. The interventions done, infections developed during hospitalization, length of hospital stay, and excessive drug load emphasize the significant impact on health costs and illustrate the importance of preventive medicine in this group of patients.
- Published
- 2020
32. Predictive Value of Routine Laboratory Parameters in Hospitalized COVID-19 Patients on Severity of Illness
- Author
-
Sevil ALKAN, Cihan YÜKSEL, Alper ŞENER, Ebru DOĞAN, Buse YÜKSEL, and Havva Yasemin ÇİNPOLAT
- Published
- 2022
33. The Role of Pneumococcal Pneumonia among Community-Acquired Pneumonia in Adult Turkish Population: TurkCAP Study
- Author
-
Ridvan Dumlu, Canan Hasanoglu, Caglar Cuhadaroglu, Birsen Mutlu, Mehmet Polatli, Ayhan Ozhasenekler, Ömer Karaşahin, Turhan Togan, Oğuz Kilinç, Firdevs Aksoy, Hakan Kati, Selami Ekin, Iftihar Koksal, Derya Yapar, Hakan Günen, Sebnem Eren Gok, Rahmet Guner, Alper Şener, Ayse Odemis, Esin Şenol, Nurdan Kokturk, Abdullah Sayiner, Ayse Sesin Kocagoz, Nurgül Sevimli, Yeşim Yıldız, Nurcan Baykam, AyŞe FÜsun TopÇu, Aykut Cilli, Huseyin Arpag, and [Belirlenecek]
- Subjects
Turkish population ,medicine.medical_specialty ,community-acquired pneumonia ,business.industry ,adult ,Burden ,Care ,medicine.disease ,Cap ,Severity ,respiratory tract diseases ,Pneumonia ,Acquired Pneumonia ,Streptococcus pneumoniae ,Antigen Test ,Internal medicine ,Pneumococcal pneumonia ,medicine ,Immunization ,Original Article ,Pathogens ,business - Abstract
OBJECTIVE: To evaluate the rate of pneumococcal pneumonia (PP) among patients with community-acquired pneumonia (CAP) in Turkey and to investigate and compare features of PP and non-PP CAP patients. MATERIAL AND METHODS: This multicenter, non-interventional, prospective, observational study included adult CAP patients (age = 18 years). Diagnosis of PP was based on the presence of at least 1 positive laboratory test result for Streptococcus pneumoniae (blood culture or sputum culture or urinary antigen test [UAT]) in patients with radiographic findings of pneumonia. RESULTS: Four hundred sixty-five patients were diagnosed with CAP, of whom 59 (12.7%) had PP. The most common comorbidity was chronic obstructive pulmonary disease (30.1%). The mean age, smoking history, presence of chronic neurological disease, and CURB-65 score were significantly higher in PP patients, when compared to non-PP patients. In PP patients, 84.8% were diagnosed based ony on the UAT. The overall rate of PP patients among CAP was calculated as 22.8% considering the UAT sensitivity ratio of 63% (95% confidence interval: 45-81). The rate of intensive care treatment was higher in PP patients (P =.007). While no PP patients were vaccinated for pneumococcus, 3.8% of the non-PP patients were vaccinated (P =.235). Antibiotic use in the preceding 48 hours was higher in the non-PP group than in the PP group (31.8% vs. 11.1%, P =.002). The CURB-65 score and the rate of patients requiring inpatient treatment according to this score were higher in the PP group. CONCLUSION: The facts that PP patients were older and required intensive care treatment more frequently as compared to non-PP patients underline the burden of PP., Pfizer Pharmaceuticals, Turkey, This work was supported by Pfizer Pharmaceuticals, Turkey.
- Published
- 2022
34. Evaluation of the Hospitalized Coronavirus Disease 2019 Patients in First 3 Months of the Pandemic
- Author
-
Sevil, Alkan, Anıl, Akça, Alper, Şener, Ebru, Doğan, Uğur, Gönlügür, Tuncer, Şimşek, Şule, Özer, Buse, Yüksel, Koray, Öz, and Kemal, Kurt
- Abstract
Data about Turkish coronavirus disease 2019 patients are limited. We evaluated hospitalized coronavirus disease 2019 patients who were followed up in the first 3 months of the pandemic.This retrospective, single-center, observational study included 415 confirmed hospitalized coronavirus disease 2019 patients. The patients were divided into groups, namely, mild, moderate, and critically ill patients. Symptoms at the time of admission, clinical, laboratory, and imaging findings were examined.In our study, 6.74% of coronavirus disease 2019 patients had severe disease, 59.5% were male, and the mortality rate was 11.3%. Diabetes mellitus and chronic obstructive pulmonary disease were more frequently seen in critically ill patient groups and hypertension in moderate patient groups. Anemia and aspartate aminotransferase levels were higher in non-survivors among mild coronavirus disease 2019 patients. In the moderate patients' group, aspartate aminotransferase, lactate dehydrogenase, international normalized ratio, ferritin, and D-dimer levels were higher and lymphocyte, hemoglobin levels were lower; in the critically ill patients' group, platelets were lower and uric acid levels were higher in non-survivor patients.In mild patients, anemia, lymphopenia, and increased aspartate aminotransferase levels; in moderate patients, leukopenia, anemia, and increased aspartate aminotransferase, lactate dehydrogenase, international normalized ratio, ferritin, and D-dimer levels; in the critically ill patient group, lower platelet and increased uric acid levels should be followed closely as they are mortality predictors.
- Published
- 2022
35. In a real-life setting, direct-acting antivirals to people who inject drugs with chronic hepatitis c in Turkey
- Author
-
Figen Sarigul, Ülkü Üser, Didem Sarı, Behice Kurtaran, Yusuf Önlen, Ebubekir Senates, Alper Gündüz, Esra Zerdali, Hasan Karsen, AYŞE BATIREL, Ritvan Karali, Rahmet Güner, Tansu Yamazhan, Sukran Kose, Nurettin Erben, Nevin İnce, Iftihar Koksal, Nefise Oztoprak, GÜLŞEN YÖRÜK, Süheyla Kömür, Tayibe Bal, Sibel Yıldız Kaya, ilkay bozkurt, ÖZGÜR GÜNAL, İlknur Esen Yıldız, Dilara Inan, Şener Barut, Mustafa Namiduru, Selma Tosun, Kamuran Türker, Alper Şener, Kenan Hizel, Nurcan Baykam, Fazilet Duygu, Hurrem Bodur, Güray Can, Hanefi Cem Gül, AyÅe SAÄMAK TARTAR, Guven Celebi, Mahmut Sünnetci, Oguz Karabay, Hayat Kumbasar, Fatma Sırmatel, Fehmi Tabak, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Yıldız, İlknur Esen
- Subjects
antivirus agent ,Genotype Distribution ,Turkey ,Seroprevalence ,complication ,Hepacivirus ,Antiviral Agents ,Drug Users ,Cohort Studies ,turkey (bird) ,Virus-Infection ,substance abuse ,chronic hepatitis C ,Humans ,human ,Prospective Studies ,Substance Abuse, Intravenous ,drug use ,Coinfection ,Hepatitis C virus ,Hiv ,clinical trial ,Hepatitis C, Chronic ,cohort analysis ,Hepatitis C ,Users ,multicenter study ,Drug users ,Hcv ,Opioid Agonist Treatment ,epidemiology ,Therapy ,Drug therapy ,Natural-History ,prospective study - Abstract
Introduction: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus (HCV) in the world. Aims: The aim of this study was to compare direct acting antivirals (DAAs) treatment of HCV for PWID and non-PWID in real life setting. Materials and methods: We performed a prospective, non-randomized, observational multi-center cohort study in 37 centers. All patients treated with DAAs therapy between April 1, 2017 to February 28, 2019 were included. In total, 2,713 patients were included in the study among which 250 were PWID and 2,463 were non-PWID. Besides patient characteristics, treatment response, follow-up and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: DAAs were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis.
- Published
- 2022
36. Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study
- Author
-
Mine Filiz, Hakan Erdem, Handan Ankarali, Edmond Puca, Yvon Ruch, Lurdes Santos, Teresa Fasciana, Anna M. Giammanco, Nesrin Ghanem-Zoubi, Xavier Argemi, Yves Hansmann, Rahmet Guner, Gilda Tonziello, Jean-Philippe Mazzucotelli, Najada Como, Sukran Kose, Ayse Batirel, Asuman Inan, Necla Tulek, Abdullah Umut Pekok, Ejaz Ahmed Khan, Atilla Iyisoy, Meliha Meric-Koc, Ayse Kaya-Kalem, Pedro Palma Martins, Imran Hasanoglu, André Silva-Pinto, Nefise Oztoprak, Raquel Duro, Fahad Almajid, Mustafa Dogan, Nicolas Dauby, Jesper Damsgaard Gunst, Recep Tekin, Deborah Konopnicki, Nicola Petrosillo, Ilkay Bozkurt, Jamal Wadi Al Ramahi, Corneliu Popescu, Ilker Inanc Balkan, Safak Ozer-Balin, Tatjana Lejko Zupanc, Antonio Cascio, Irina Magdalena Dumitru, Aysegul Erdem, Gulden Ersoz, Meltem Tasbakan, Oday Abu Ajamieh, Fatma Sirmatel, Simin Florescu, Serda Gulsun, Hacer Deniz Ozkaya, Sema Sari, Selma Tosun, Meltem Avci, Yasemin Cag, Guven Celebi, Ayse Sagmak-Tartar, Sumeyra Karakus, Alper Sener, Arjeta Dedej, Serkan Oncu, Rosa Fontana Del Vecchio, Derya Ozturk-Engin, and Canan Agalar
- Subjects
Infective endocarditis ,Blood culture negative endocarditis ,Rheumatic heart disease ,Prosthetic valves ,Cardiac disorders ,Infectious and parasitic diseases ,RC109-216 - Abstract
Background: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI). The study analysing one of the largest case series ever reported was conducted across 41 centers in 13 countries. We analysed the database to determine the predictors of BCNE using univariate and logistic regression analyses. Results: Blood cultures were negative in 101 (11.65 %) of 867 patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95 % CI 0.963–0.987, p
- Published
- 2024
- Full Text
- View/download PDF
37. NS5A resistance – associated substitutions in chronic hepatitis C patients with direct acting antiviral treatment failure in Turkey
- Author
-
Alper Şener, Engin Altintaş, Gülden Ersöz, Selver Can, Mehmet Gökhan Demir, Sıla Akhan, Figen Sarigul Yildirim, Murat Sayan, Mehmet Çabalak, Fatih Ensaroğlu, Göktuğ Şirin, Ayhan Akbulut, Aydın Deveci, Arzu Altunçekiç Yıldırım, İstinye Üniversitesi, Hastane, and Ensaroglu, Fatih
- Subjects
Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Genotyping Techniques ,Turkey ,Hepatitis C virus ,030106 microbiology ,Population ,Hepacivirus ,Disease ,Viral Nonstructural Proteins ,medicine.disease_cause ,Antiviral Agents ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,0302 clinical medicine ,Chronic hepatitis ,Recurrence ,Internal medicine ,Drug Resistance, Viral ,Humans ,Medicine ,lcsh:RC109-216 ,Longitudinal Studies ,Prospective Studies ,030212 general & internal medicine ,NS5A ,education ,Aged ,education.field_of_study ,business.industry ,Sequence analysis ,Genetic Variation ,General Medicine ,Hepatitis C ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,Regimen ,Infectious Diseases ,Treatment failure ,Female ,business ,Direct acting ,NS-5 protein - Abstract
Objectives: Chronic hepatitis C (CHC) is now a more curable disease with new direct acting antivirals (DAA). Although high sustained virologic response rates, failures still occur in DAA regimens. Our objective in this study was to characterize the real-life presence of clinically relevant resistance - associated substitutions (RASs) in the HCV NS5A gene in CHC patients whose DAA regimen has failed. Methods: The study enrolled 53 CHC patients who experienced failure with DAA regimen as the prospective longitudinal cohort between 2017-2019. Genotypic resistance testing was performed via the viral population sequencing method and The Geno2pheno HCV tool was used for RAS analysis. Results: The most frequent failure category was relapse (88%) followed by non-responder (12%). For a total of 36% of patients, RASs was detected in NS5A, Y93H was the most detected RAS in GT1b infected patients (89%). Conclusions: This study establishes an HCV failure registry for Turkey in which samples were combined with clinical, virologic and molecular data of adult patients whose DAA therapy failed. RASs can occur in CHC patients with DAA treatment failures. Evaluation of RAS after DAA failure is very important before retreatment is initiated to prevent virologic failure. (C) 2020 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. WOS:000540737100014 32302766 Q2
- Published
- 2020
38. Seroprevalence of Hepatitis E in Hospital Employees and Investigation of Risk Factors
- Author
-
Alper Şener and Ozlem Cakmak Topfedaisi
- Subjects
Microbiology (medical) ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,Family medicine ,Medicine ,Seroprevalence ,Hospital employees ,business ,Hepatitis E ,medicine.disease - Published
- 2020
39. COVID-19 (SARS Cov-2) Treatment
- Author
-
Alper Şener
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Ambulatory care ,business.industry ,Intensive care ,medicine ,General Earth and Planetary Sciences ,Intensive care medicine ,business ,Patient care ,General Environmental Science - Abstract
Korona virüs aralık 2019’un sonu itibari ile tüm dünyada yaygınlaşmış ve Mart 2020’den sonra ülkemizde de yaygın görülmeye başlamıştır. Tedavide uygulanan antiviral ilaçlardan sitokin reseptör antagonistlerine kadar çok geniş bir yelpazededir. Burada ayaktan hasta bakımındaki tedavi önerileri ile birlikte yoğun bakımdaki kritik hasta bakımı önerileri de yer almaktadır.
- Published
- 2020
40. Which is More Important and Insidious in Dialysis Patients? Occult Hepatitis B or Occult Hepatitis C?
- Author
-
Alper Şener and Özlem Zanapalıoğlu Gazel
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Hepatitis C ,Hepatitis B ,medicine.disease ,Dialysis patients ,business ,Occult ,Gastroenterology - Published
- 2020
41. Molecular Identification of HIV-1 in the Presence of Hepatitis B Virus and Hepatitis C Virus Co-infections
- Author
-
Yasemin Heper, Murat Sayan, Başak Dokuzoğuz, Muge Ozguler, Saadet Yazici, Mustafa Kemal Çelen, Figen Sarigul Yildirim, Gülden Ersöz, Aydın Deveci, Servet Öztürk, Nurgul Ceran, Hülya Özkan Özdemir, Serhat Ünal, Taner Yildirmak, Selda Sayin Kutlu, Ayhan Akbulut, Atahan Cagatay, Alper Gunduz, Dilara Inan, Alper Şener, Ilkay Karaoglan, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı, Çelen, Mustafa Kemal, OMÜ, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., Heper, Yasemin, and AAH-6506-2021
- Subjects
0301 basic medicine ,hepatitis C virus ,HBsAg ,Turkey ,genotype ,polymerase chain reaction ,retrospective study ,viruses ,lcsh:Medicine ,RNA directed DNA polymerase inhibitor ,HIV Infections ,Hepacivirus ,RNA directed DNA polymerase ,Procedures ,medicine.disease_cause ,molecular epidemiology ,Polymerase Chain Reaction ,Turkey (republic) ,Western blotting ,Viral Load ,Dried Blood Spot Testing ,Human Immunodeficiency Virus 1 ,0302 clinical medicine ,Turkey (bird) ,030212 general & internal medicine ,gene mutation ,disease transmission ,Hepatitis C virus ,Coinfection ,Etrospective study ,adult ,General Medicine ,Hepatitis B ,Resistance mutation ,Hepatitis C ,mixed infection ,Co-infection ,Medicine, general & internal ,Impact ,female ,virus resistance ,laboratory test ,virus gene ,proteinase ,Original Article ,Viral hepatitis ,Hepatitis B virus ,030106 microbiology ,prevalence ,gene sequence ,Infections ,Pathophysiology ,Virus ,Article ,03 medical and health sciences ,male ,Human immunodeficiency virus infection ,Virology ,medicine ,proteinase inhibitor ,Adults ,Pathogenicity ,cross-sectional study ,Humans ,controlled study ,human ,infection risk ,virus detection ,Retrospective Studies ,Hepatitis ,business.industry ,lcsh:R ,nonnucleoside reverse transcriptase inhibitor ,medicine.disease ,major clinical study ,enzyme linked immunosorbent assay ,hepatitis B surface antigen ,Cross-Sectional Studies ,HIV-1 ,hepatitis B ,General & internal medicine ,hepatitis C ,business - Abstract
Bu çalışma, 14-17 Eylül 2016 tarihleri arasında Lizbon[Portekiz]'de düzenlenen 19. Meeting of the European Society for Clinical Virology'de bildiri olarak sunulmuştur. Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency vim were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Antihuman immunodeficiency virus positive patients with HBsAg andior anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-I infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative. European Society for Clinical Virology
- Published
- 2020
42. Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?
- Author
-
Sevil Alkan, Alper Şener, Ebru Doğan, Cihan Yüksel, and Buse Yüksel
- Subjects
General Medicine - Abstract
Objectives: COVID-19 associated coagulopathy and prophylactic anticoagulant therapy (PAT) are ongoing topics globally. Using PAT for anti-inflammatory effect may prevent thromboembolic events (TEEs). The objective of this study was to determine the anti-inflammatory effects of PAT in hospitalized COVID-19 patients. Methods: We conducted a retrospective observational study in a tertiary pandemic hospital. Patients were divided into two categories according to their PAT therapy status (PAT (+) and PAT (-)) and into three categories according to clinical features (mild: group 1; moderate: group: 2; and severe: group 3). We then evaluated laboratory parameters and clinical courses. Results: We included 662 hospitalized COVID-19 patients in this study. Enoxaparin sodium was given to all patients as PAT therapy. TEE was developed in five patients in the PAT (+) group. Pulmonary embolism developed in 3/5 patients and deep venous thrombosis in 2/5 patients. Disseminated intravascular coagulation (DIC) was detected in 54 patients in group 3. No statistically significant difference was found in 28-day mortality, development of DIC rates, intubation rates, and TEEs. Conclusions: The use of PAT in critically ill patients was not effective in reducing C-reactive protein, which is one of the biomarkers of inflammation.
- Published
- 2021
43. Evaluation of the Quality and Reliability of Youtube Videos on Neurological Symptoms of COVID-19
- Author
-
Özgül OCAK and Alper ŞENER
- Subjects
COVID-19,neurologic symptoms,Instructional Film and Video ,Medicine ,General Medicine ,Tıp - Abstract
PurposeThe objective of this study was to investigate scientific and quality accuracy of videos related to neurological symptoms of COVID -19 on YouTube.MethodsYouTube searches was performed using keywords “COVID -19 Neurological Symptoms” and the first 50 YouTube videos about Neurological Symptoms of COVID -19 with the highest view counts were evaluated by one neurologist and one infectious disease specialist with DISCERN and JAWA scoring systems. ResultsVideos uploaded by health channels (50%), news channels (26%), physicians (22%), or patients (2%). The mean Video Power Index value was 95.51. The mean DISCERN and JAMA scores were 46.59±10.90, and 2.87±0.65. Health Channel mean DISCERN and JAMA scores were significantly higher than News Channel scores. There is no statistically significant correlation between DISCERN or JAMA scores and view counts, view rate, comment counts, like counts, or dislike counts.ConclusionCorrect use of Youtube can play an important role in successfully conducting the COVID-19 outbreak. With the increase of the publication of these videos by Neurologists, the spread of false information can be minimized.
- Published
- 2021
44. The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study
- Author
-
Dilşah Başkol Elik, Şafak Kaya, Sevil Alkan, Tuna Demirdal, Alper Sener, Selçuk Kaya, Özlem Güzel Tunçcan, Bircan Kayaaslan, Rahmet Güner, Fatma Eser, Hasip Kahraman, Serhat Birengel, Elif Mukime Sarıcaoğlu, Esma Eroğlu, Fatma Çölkesen, Erman Öztürk, Hande Berk Cam, Çiğdem Mermutluoğlu, Şafak Özer Balin, Gülden Sincan, Nilgün Altın, Uluhan Sili, Bedia Mutay Suntur, Tuğba Arslan Gülen, Burak Deveci, Rabin Saba, Şaban İncecik, Gülden Eser Karlıdağ, Elif Hakko, Damla Akdağ, Hüseyin Aytaç Erdem, Hilal Sipahi, Candan Çicek, Mehmet Sezai Taşbakan, Meltem Taşbakan, Hüsnü Pullukçu, Tansu Yamazhan, Bilgin Arda, Sercan Ulusoy, and Oguz Resat Sipahi
- Subjects
Medicine ,Science - Abstract
Abstract This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020–15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639–16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137–20.172), the need for mechanical ventilation (p
- Published
- 2024
- Full Text
- View/download PDF
45. Current status of HIV/AIDS-syphilis co-infections: a retrospective multicentre study
- Author
-
Mustafa Kemal Çelen, Ferit Kuşcu, Alper Şener, Atahan Cagatay, Aydın Deveci, Hülya Özkan Özdemir, Seyit Ali Büyüktuna, Murat Sayan, Gül Karagöz, Selda Sayin Kutlu, Başak Dokuzoğuz, Ilkay Karaoglan, Selçuk Kaya, Ayhan Akbulut, Gülden Ersöz, Özgür Günal, Dilara Inan, Rabin Saba, Oguz Karabay, Cigdem Ataman Hatipoglu, Nurgul Ceran, Yasemin Heper, Figen Sarigul, Nurettin Erben, Sargul, F, Sayan, M, Inan, D, Deveci, A, Ceran, N, Celen, MK, Cagatay, A, Ozdemir, HO, Kuscu, F, Karagoz, G, Heper, Y, Karabay, O, Dokuzoguz, B, Kaya, S, Erben, N, Karaoglan, I, Ersoz, GM, Gunal, O, Hatipoglu, C, Kutlu, SS, Akbulut, A, Saba, R, Sener, A, Buyuktuna, SA, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Karabay, Oğuz, OMÜ, and Çukurova Üniversitesi
- Subjects
Male ,Pediatrics ,Turkey ,retrospective study ,syphilis ,HIV Infections ,Coinfection ,HIV ,HIV Infections/epidemiology ,Homosexuality, Male/statistics & numerical data ,Humans ,Longitudinal Studies ,Prevalence ,Retrospective Studies ,Sexual Behavior/statistics & numerical data ,Sexual and Gender Minorities ,Syphilis/epidemiology ,Men who have sex with men ,male homosexuality ,0302 clinical medicine ,Epidemiology ,030212 general & internal medicine ,Public, Environmental & Occupational Health ,Sexually transmitted diseases ,0303 health sciences ,Human immunodeficiency virus ,longitudinal study ,virus diseases ,clinical trial ,General Medicine ,mixed infection ,medicine.medical_specialty ,Sexual Behavior ,prevalence ,Neurosyphilis ,03 medical and health sciences ,Acquired immunodeficiency syndrome (AIDS) ,Human immunodeficiency virus infection ,sexual and gender minority ,turkey (bird) ,medicine ,human ,Syphilis ,Homosexuality, Male ,business.industry ,Public Health, Environmental and Occupational Health ,030311 toxicology ,Retrospective cohort study ,medicine.disease ,multicenter study ,Sexual orientation ,business - Abstract
Gunal, Ozgur/0000-0002-7744-4123; KARABAY, OGUZ/0000-0003-1514-1685 WOS: 000490537600009 PubMed: 31580558 Objective: Treponema pallidum and HIV are transmitted frequently through sexual contact, these agents with epidemiological similarities co-infect the same host. The current number of HIV-infected cases in Turkey is increasing. For this reason, we aimed to reveal the characteristics of syphilis in HIV/AIDS cases. Methods: A retrospective longitudinal cohort study was performed, patients were followed up at 24 clinics in 16 cities from all seven regions of Turkey between January 2010 to April 2018. We examined the socio-demographic characteristics, laboratory parameters and neurosyphilis association in HIV/AIDS-syphilis co-infected cases. Results: Among 3,641 patients with HIV-1 infection, 291 (8%) patients were diagnosed with syphilis co-infection. Most patients were older than 25 years (92%), 96% were males, 74% were working, 23% unemployed, and 3% were students. The three highest prevalence of syphilis were in Black Sea (10.3%), Mediterranean (8.4%) and Marmara Regions (7.4%). As for sexual orientation, 46% were heterosexuals, 42% men who have sex with men (MSM), and no data available for 12%. Patients with the number of CD4+
- Published
- 2019
46. Brucellosis in pregnancy: results of multicenter ID-IRI study
- Author
-
Seval Bilgic-Atli, Hakan Erdem, Ayşe Erbay, Nicholas J. Beeching, Ergin Ayaslioglu, Recep Tekin, Mile Bosilkovski, S. Sahin, Mehmet Ulug, Tuna Demirdal, Serap Ural, Alper Şener, Tansu Yamazhan, Asuman Inan, Emsal Aydin, Selma Tosun, Asli Haykir-Solay, Serda Gulsun, Selçuk Kaya, Nazif Elaldi, Pınar Ergen, Abdullah Umut Pekok, Elif Sahin-Horasan, Murat Muhcu, Mustafa Kasim Karahocagil, Mahmut Sunnetcioglu, Ayten Kadanali, Yakup Cag, Ali Avci, Şafak Kaya, Kırıkkale Üniversitesi, and [Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, Hakan] Gulhane Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, Serda -- Kaya, Safak -- Bilgic-Atli, Seval] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karahocagil, Mustafa K.] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Pekok, Abdullah U.] Pendik Med Pk Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ulug, Mehmet] Private Umut Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Bosilkovski, Mile] Skopje Med Fac, Dept Infect Dis & Febrile Condit, Skopje, Macedonia -- [Haykir-Solay, Asli] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Demirdal, Tuna -- Ural, Serap] Katip Celebi Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Aydin, Emsal] Kafkas Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kars, Turkey -- [Yamazhan, Tansu] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Muhcu, Murat] GATA Haydarpasa Training Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Ayaslioglu, Ergin] Kirikkale Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kirikkale, Turkey -- [Erbay, Ayse] Bozok Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Yozgat, Turkey -- [Ergen, Pinar] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kadanali, Ayten] Umraniye Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Sahin, Suzan] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Avci, Ali] Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Urol, Izmir, Turkey -- [Cag, Yakup] Turkish Hlth Sci Univ, Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Beeching, Nicholas J.] Univ Liverpool Liverpool Sch Trop Med, Clin Sci, Liverpool, Merseyside, England
- Subjects
Adult ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,Fever ,Turkey ,030106 microbiology ,Bacteremia ,Oligohydramnios ,Abortion ,Brucellosis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Abortus ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,Retrospective Studies ,Intrauterine fetal demise ,Obstetrics ,business.industry ,Infant, Newborn ,General Medicine ,Middle Aged ,medicine.disease ,Brucella ,Abortion, Spontaneous ,Low birth weight ,Cross-Sectional Studies ,Infectious Diseases ,Risk factors ,Splenomegaly ,Cohort ,Vomiting ,Female ,medicine.symptom ,business - Abstract
WOS: 000471726700008, PubMed ID: 30989418, Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
- Published
- 2019
47. Q Fever in the Differential Diagnosis of COVID 19 Infection
- Author
-
Safiye Bilge Güçlü Kayta, Anıl Akça, Sevil Alkan, and Alper Şener
- Subjects
General and Internal Medicine ,biology ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Q fever ,Coxiella burnetii ,biology.organism_classification ,medicine.disease ,Virology ,medicine ,General Earth and Planetary Sciences ,Differential diagnosis ,business ,Q Fever,Coxiella burnetii,COVID 19 ,Genel ve Dahili Tıp ,General Environmental Science - Abstract
Coxiella burnetii is an intracellular, Gram-negative bacteria and is the causative agent of Q fever, a zoonosis first described in Australia in 1937. It can cause endemics around the world. People usually get the disease by inhaling the contaminated aerosol produced by infected livestock. Contaminated milk, intradermal inoculation, sexual contact, blood transfusion, and transplacental route may also occur. The infective dose for humans is 1-10 bacteria. It is resistant to environmental conditions and can remain alive in animal wastes such as dust and fertilizer. Acute infection is typically asymptomatic or may manifest as a febrile flu-like illness, pneumonia, hepatitis, and central nervous system (CNS) infection. Q fever outbreaks are often caused by occupational exposure that includes shepherds, animal keepers, veterinarians, slaughterhouses or dairy workers, and laboratory personnel working with C. burnetii. During the course of the disease that cannot be distinguished from other pneumonia clinically; 2-10 fold increase in liver function tests, leukocytosis and thrombocytopenia, erythrocyte sedimentation rate and creatine kinase increase may be observed or laboratory findings may be normal. An immunofluorescent antibody (IFA) test, which is a serological reference method, should be requested from patients suspected for the diagnosis of Q fever.
- Published
- 2021
48. Real-World Data from Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?
- Author
-
Nese Saltoglu, Ziya Kuruüzüm, Nesrin Türker, Petek Konya, Alper Şener, Uluhan Yıldız, Gunay Tuncer Ertem, Kaya Suer, Bilgehan Aygen, Hüseyin Bilgin, Dilara Inan, Onur Ural, Bahar Ormen, Nazlim Aktug Demir, Sumeyra Simsek, Orhan Yildiz, Reşit Mistik, Hüseyin Tarakçı, Nurhan Doğan, Pinar Korkmaz, Rıza Aytaç Çetinkaya, Emine Türkoğlu, Deniz Kamalak Güzel, Gülden Ersöz, Neşe Demirtürk, Ismail Necati Hakyemez, Yunus Gürbüz, Faruk Karakeçili, Necla Tulek, Sami Kinikli, Atahan Cagatay, Nazan Tuna, Ayse Batirel, Ali Asan, İlhami Çelik, Mustafa Kemal Çelen, Sener Barut, Selcan Arslan Ozel, Funda Şimşek, Sıla Akhan, Sinan Ozturk, Demirtürk, Neşe, Türkoğlu, Emine, Doğan, Nurhan, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı, and Çelen, Mustafa Kemal
- Subjects
Ledipasvir ,medicine.medical_specialty ,Sofosbuvir ,Side effect ,Turkey ,Genotype ,Hepacivirus ,Chronic hepatitis C ,Antiviral Agents ,chemistry.chemical_compound ,Internal medicine ,Ribavirin ,Medicine ,Humans ,Infectious disease (athletes) ,Adverse effect ,Fluorenes ,business.industry ,Gastroenterology ,Hepatitis C, Chronic ,Hepatitis C ,Real-world data ,Discontinuation ,Sustained virological response ,Treatment Outcome ,chemistry ,Original Article ,Benzimidazoles ,Drug Therapy, Combination ,Female ,business ,medicine.drug - Abstract
WOS:000648816400007 PMID: 33960939 Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice. Methods: Data from patients with chronic hepatitis C treated with SOF/LDV +/- RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 +/- 14.2, and 293 (55.8%) were female. The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at baseline in 381 patients (72.6%). SOF/LDV +/- RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes. All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect. Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV +/- RBV treatment in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment.
- Published
- 2021
49. Relationship between in-hospital mortality and inflammation markers in COVID-19 patients with the diagnosis of coronary artery disease
- Author
-
Alper Şener, Sevil Alkan Çeviker, and Uğur Küçük
- Subjects
covid-19 ,ölüm ,Health Care Sciences and Services ,COVID-19,ölüm,koroner arter hastalığı ,Medicine ,koroner arter hastalığı ,COVID-19,mortality,coronary artery disease ,Sağlık Bilimleri ve Hizmetleri ,mortality ,coronary artery disease - Abstract
Giriş: Enflamasyon, koroner arter hastalıklarının temelinde ve olumsuz sonlanımlarında önemli rol oynar. Nötrofil-lenfosit oranı (NLR), sistemik immün inflamasyon indeksi (SII) ve CRP ise inflamatuar durumu yansıtan basit ve kullanışlı belirteçlerdir. Çalışmamızın amacı bu belirteçlerin koroner arter hastalığı tanılı COVID-19 hastalarında hastane içi mortaliteyi öngörmede kullanılabilirliğini değerlendirmeyi amaçladık.Gereç ve Yöntem: Çalışmamız 111 (48 erkek, 63 kadın) yeni tanı COVID-19 hastasından oluşuyordu. Nötrofil (N), lenfosit (L) değerleri kullanılarak NLR (N/L) ve N,L ve trombosit (P) değerleri kullanılarak sistemik immün inflamasyon indeksi SII (NxP / L) elde edildi. NLR, SII ve CRP değerlerinin hastane içi mortaliteyle olan ilişkileri incelendi.Bulgular: Tedavi sürecinde 16 hastada ölüm izlendi. N, L ve P değerleri hayatını kaybenler ve şifa ile taburcu olan grup arasında kıyaslandığında istatiksel farklılıklar izlenmedi ( p= 0.971, p=0.256, p=0.759 sırasıyla). Bunların kombinasyonu ile elde edilen SII ve NLR değerleri içinde gruplar arasında istatiksel farklılıklar izlenmezken (p=0.872, p=0.979 sırasıyla), CRP değerlerinde ise hastane içi ölüm izlenen grupta istatiksel anlamlıydı (p, Introduction: Inflammation plays an important role in the basis of coronary artery diseases and their adverse outcomes. Neutrophil-lymphocyte ratio (NLR), Systemic Immune Inflammation Index (SII) and C-reactive protein (CRP) are simple and useful markers that reflect the inflammatory state. Our study evaluated the usability of these markers in predicting in-hospital mortality in patients with COVID-19 with the diagnosis of coronary artery disease.Material and Method: Our study population consisted of 111 (48 male, 63 female) newly diagnosed patients with COVID-19. Neutrophil-lymphocyte ratio (NLR) was estimated using neutrophil (N), and lymphocyte (L) counts and the systemic immune inflammation index SII (NxP / L) was calculated using N, L and platelet (P) values. The relationship of NLR, SII and CRP values with in-hospital mortality was investigated.Results: During the treatment process, 16 patients exited. Any statistically significant intergroup difference was not observed as for SII and NLR values obtained by their use in combination (p = 0.872, p = 0.979, respectively), CRP values were statistically significant in the group with in-hospital mortality (p
- Published
- 2021
50. A fatal rabies case and experiences of a mass post exposure prophylaxis among healthcare workers
- Author
-
Canan Akman, Alper Şener, Anıl Akça, and Behcet Varisli
- Subjects
0303 health sciences ,medicine.medical_specialty ,General Immunology and Microbiology ,030306 microbiology ,business.industry ,Transmission (medicine) ,medicine.medical_treatment ,Technician ,General Medicine ,medicine.disease ,03 medical and health sciences ,Sexual intercourse ,0302 clinical medicine ,Rabies vaccine ,Internal medicine ,medicine ,Infection control ,Rabies ,030212 general & internal medicine ,Post-exposure prophylaxis ,Adverse effect ,business ,medicine.drug - Abstract
We aimed to monitor the adverse effects (AE) and efficacy of post exposure prophylaxis (PEP) in health care workers (HCWs) exposed to a rabies patient. In this study 109 HCWs and eight household contacts were PEP candidates. Contact persons without infection control precautions were in Group I (high risk-82 cases). HCWs indirectly exposed to environmental surfaces were classified in Group II (low risk-35 cases). PEP schedule was rabies vaccine (RBV) + equine rabies immunoglobulin (eRIG) in Group I and only RBV in Group II. Local and systemic AE were observed in all cases. Efficacy of post exposure prophylaxis (PEP) was determined by rabies development in a six month follow-up. 585 doses of RBV have been used in 117 cases and eRIG has been used in 82 cases. 32 Nurses (39%); 22 emergency medicine technicians (26.8%); 12 doctors (14%); six laboratory technicians (0.07%); six radiology technicians (0.07%); four cleaners (0.05%) were in Group I (82 cases), respectively. One doctor, laboratory technician, nurse and radiology technician (0.02%); two emergency medicine technicians (0.04%) and nine cleaners (25.7%) were in Group II (35 cases), respectively. Routes of transmission were blood in five (0.06%); saliva in 14 (17%); sweat in 50 (61%); CSF/serum in five (0.06%); sexual intercourse in one (0.01%); personal equipment in seven (0.09%) in Group I, respectively. Indirect contact was the only route in Group II. The most common local and systemic AE were seen in Group I; pain at injection side (19 cases) and fever (13 cases). Both of them showed statistically significant difference (P
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.