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Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period
- Source :
- Irish Journal of Medical Science
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background The effect of preadmission metformin usage (PMU) on the mortality of coronavirus disease-2019 (COVID-19) patients with diabetes is conflicting. Most studies have focused on in-hospital mortality; however, mortality after discharge also increases in COVID-19 patients. Aims Examining the effect of PMU on all-cause mortality, including the post-discharge period. Methods Patients with diabetes who were hospitalised in 2020 due to COVID-19 were included in the study. They were divided into two groups: those with a history of metformin use (MF( +)) and those without such history (MF( −)). Propensity score matching (PSM) was performed at a ratio of 1:1 for age and sex. COX regression analyses were used to demonstrate risk factors for mortality. Results We investigated 4103 patients hospitalised for COVID-19. After excluding those without diabetes or with chronic liver/kidney disease, we included the remaining 586 patients, constituting 293 women (50%) with an overall mean age of 66 ± 11.9 years. After PSM analysis, the in-hospital and post-discharge mortality rates were higher in the MF( −) group though not significantly different. However, overall mortality was higher in the MF( −) group (51 (42.5%) vs. 35 (29.2%), p = 0.031). For overall mortality, the adjusted HR was 0.585 (95% CI: 0.371 − 0.920, p = 0.020) in the MF( +) group. Conclusion PMU is associated with reducing all-cause mortality. This effect starts from the in-hospital period and becomes more significant with the post-discharge period. The main limitations were the inability to evaluate the compliance with metformin and the effects of other medications due to retrospective nature.
- Subjects :
- medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Post discharge
Aftercare
Cohort Studies
Internal medicine
Diabetes mellitus
medicine
Humans
Hypoglycemic Agents
Mortality
Aged
Retrospective Studies
Coronavirus disease 2019
business.industry
Proportional hazards model
Mortality rate
Preadmission
General Medicine
Middle Aged
medicine.disease
Metformin
Patient Discharge
COVID-19 Drug Treatment
Treatment
Diabetes Mellitus, Type 2
Propensity score matching
Female
Original Article
business
medicine.drug
Kidney disease
Subjects
Details
- ISSN :
- 18634362 and 00211265
- Volume :
- 191
- Database :
- OpenAIRE
- Journal :
- Irish Journal of Medical Science (1971 -)
- Accession number :
- edsair.doi.dedup.....1cb7a98fad58e31c47843cdcf00fcbac