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1. The Energy Worker Profiler from Technologies to Skills to Realize Energy Efficiency in Manufacturing

Author

Fareri, Silvia, Apreda, Riccardo, Mulas, Valentina, and Alonso, Ruben

Subjects
Computer Science - Computation and Language, Computer Science - Computers and Society
Abstract

In recent years, the manufacturing sector has been responsible for nearly 55 percent of total energy consumption, inducing a major impact on the global ecosystem. Although stricter regulations, restrictions on heavy manufacturing and technological advances are increasing its sustainability, zero-emission and fuel-efficient manufacturing is still considered a utopian target. In parallel,companies that have invested in digital innovation now need to align their internal competencies to maximize their return on investment. Moreover, a primary feature of Industry 4.0 is the digitization of production processes, which offers the opportunity to optimize energy consumption. However, given the speed with which innovation manifests itself, tools capable of measuring the impact that technology is having on digital and green professions and skills are still being designed. In light of the above, in this article we present the Worker Profiler, a software designed to map the skills currently possessed by workers, identifying misalignment with those they should ideally possess to meet the renewed demands that digital innovation and environmental preservation impose. The creation of the Worker Profiler consists of two steps: first, the authors inferred the key technologies and skills for the area of interest, isolating those with markedly increasing patent trends and identifying green and digital enabling skills and occupations. Thus, the software was designed and implemented at the user-interface level. The output of the self-assessment is the definition of the missing digital and green skills and the job roles closest to the starting one in terms of current skills; both the results enable the definition of a customized retraining strategy. The tool has shown evidence of being user-friendly, effective in identifying skills gaps and easily adaptable to other contexts.

Published
2023

4. Human-Centric Artificial Intelligence Architecture for Industry 5.0 Applications

Author

Rožanec, Jože M., Novalija, Inna, Zajec, Patrik, Kenda, Klemen, Tavakoli, Hooman, Suh, Sungho, Veliou, Entso, Papamartzivanos, Dimitrios, Giannetsos, Thanassis, Menesidou, Sofia Anna, Alonso, Ruben, Cauli, Nino, Meloni, Antonello, Recupero, Diego Reforgiato, Kyriazis, Dimosthenis, Sofianidis, Georgios, Theodoropoulos, Spyros, Fortuna, Blaž, Mladenić, Dunja, and Soldatos, John

Subjects
Computer Science - Artificial Intelligence
Abstract

Human-centricity is the core value behind the evolution of manufacturing towards Industry 5.0. Nevertheless, there is a lack of architecture that considers safety, trustworthiness, and human-centricity at its core. Therefore, we propose an architecture that integrates Artificial Intelligence (Active Learning, Forecasting, Explainable Artificial Intelligence), simulated reality, decision-making, and users' feedback, focusing on synergies between humans and machines. Furthermore, we align the proposed architecture with the Big Data Value Association Reference Architecture Model. Finally, we validate it on three use cases from real-world case studies.

Published
2022

5. STARdom: an architecture for trusted and secure human-centered manufacturing systems

Author

Rožanec, Jože M., Zajec, Patrik, Kenda, Klemen, Novalija, Inna, Fortuna, Blaž, Mladenić, Dunja, Veliou, Entso, Papamartzivanos, Dimitrios, Giannetsos, Thanassis, Menesidou, Sofia Anna, Alonso, Rubén, Cauli, Nino, Recupero, Diego Reforgiato, Kyriazis, Dimosthenis, Sofianidis, Georgios, Theodoropoulos, Spyros, and Soldatos, John

Subjects
Computer Science - Artificial Intelligence, Computer Science - Software Engineering
Abstract

There is a lack of a single architecture specification that addresses the needs of trusted and secure Artificial Intelligence systems with humans in the loop, such as human-centered manufacturing systems at the core of the evolution towards Industry 5.0. To realize this, we propose an architecture that integrates forecasts, Explainable Artificial Intelligence, supports collecting users' feedback, and uses Active Learning and Simulated Reality to enhance forecasts and provide decision-making recommendations. The architecture security is addressed as a general concern. We align the proposed architecture with the Big Data Value Association Reference Architecture Model. We tailor it for the domain of demand forecasting and validate it on a real-world case study.

Published
2021

6. Machine Learning Based System for the Control and Evaluation of Programming Vulnerabilities

Author

Alonso-García, María, Fuente-Alonso, Rubén, Corchado, Juan M., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Julián, Vicente, editor, Carneiro, João, editor, Alonso, Ricardo S., editor, Chamoso, Pablo, editor, and Novais, Paulo, editor

Published
2023
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13. Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial

Author

Perkovic, Vlado, Mahaffey, Kenneth W., Agarwal, Rajiv, Bakris, George, Brenner, Barry M., Cannon, Christopher P., Charytan, David M., de Zeeuw, Dick, Greene, Tom, Jardine, Meg J., Heerspink, Hiddo J.L., Levin, Adeera, Meininger, Gary, Neal, Bruce, Pollock, Carol, Wheeler, David C., Zhang, Hong, Zinman, Bernard, Jardine, Meg, Li, Nicole, Kolesnyk, Inna, Aizenberg, Diego, Pecoits-Filho, Roberto, Cherney, David, Obrador, Gregorio, Chertow, Glenn, Chang, Tara, Hawley, Carmel, Ji, Linong, Wada, Takashi, Jha, Vivekanand, Lim, Soo Kun, Lim-Abrahan, Mary Anne, Santos, Florence, Chae, Dong-Wan, Hwang, Shang-Jyh, Vazelov, Evgueniy, Rychlík, Ivan, Hadjadj, Samy, Krane, Vera, Rosivall, László, De Nicola, Luca, Dreval, Alexander, Nowicki, Michał, Schiller, Adalbert, Distiller, Larry, Górriz, Jose L., Kolesnyk, Mykola, David, Wheeler, C., Guerrero, Rodolfo Andres Ahuad, Albisu, Juan Pablo, Alvarisqueta, Andres, Bartolacci, Ines, Berli, Mario Alberto, Bordonava, Anselmo, Calella, Pedro, Cantero, Maria Cecilia, Cartasegna, Luis Rodolfo, Cercos, Esteban, Coloma, Gabriela Cecilia, Colombo, Hugo, Commendatore, Victor, Cuadrado, Jesus, Cuneo, Carlos Alberto, Cusumano, Ana Maria, Douthat, Walter Guillermo, Dran, Ricardo Dario, Farias, Eduardo, Fernandez, Maria Florencia, Finkelstein, Hernan, Fragale, Guillermo, Fretes, Jose Osvaldo, Garcia, Nestor Horacio, Gastaldi, Anibal, Gelersztein, Elizabeth, Glenny, Jorge Archibaldo, Gonzalez, Joaquin Pablo, Colaso, Patricia del Carmen Gonzalez, Goycoa, Claudia, Greloni, Gustavo Cristian, Guinsburg, Adrian, Hermida, Sonia, Juncos, Luis Isaias, Klyver, Maria Isabel, Kraft, Florencia, Krynski, Fernando, Lanchiotti, Paulina Virginia, Leon de la Fuente, Ricardo Alfonso, Marchetta, Nora, Mele, Pablo, Nicolai, Silvia, Novoa, Pablo Antonio, Orio, Silvia Ines, Otreras, Fabian, Oviedo, Alejandra, Raffaele, Pablo, Resk, Jorge Hector, Rista, Lucas, Papini, Nelson Rodriguez, Sala, Jorgelina, Santos, Juan Carlos, Schiavi, Lilia Beatriz, Sessa, Horacio, Casabella, Tomas Smith, Ulla, Maria Rosa, Valdez, Maria, Vallejos, Augusto, Villarino, Adriana, Visco, Virginia Esther, Wassermann, Alfredo, Zaidman, Cesar Javier, Cheung, Ngai Wah, Droste, Carolyn, Fraser, Ian, Johnson, David, Mah, Peak Mann, Nicholls, Kathy, Packham, David, Proietto, Joseph, Roberts, Anthony, Roger, Simon, Tsang, Venessa, Raduan, Roberto Abrão, Costa, Fernando Augusto Alves da, Amodeo, Celso, Turatti, Luiz Alberto Andreotti, Bregman, Rachel, Sanches, Fernanda Cristina Camelo, Canani, Luis Henrique, Chacra, Antônio Roberto, Borges, João Lindolfo Cunha, Vêncio, Sérgio Alberto Cunha, Franco, Roberto Jorge da Silva, d’Avila, Domingos, Portes, Evandro de Souza, de Souza, Pedro, Deboni, Luciane Mônica, Fraige Filho, Fadlo, Neto, Bruno Geloneze, Gomes, Marcus, Kohara, Suely Keiko, Keitel, Elizete, Saraiva, Jose Francisco Kerr, Lisboa, Hugo Roberto Kurtz, Contieri, Fabiana Loss de Carvalho, Milagres, Rosângela, Junior, Renan Montenegro, de Brito, Claudia Moreira, Hissa, Miguel Nasser, Sabbag, Ângela Regina Nazario, Noronha, Irene, Panarotto, Daniel, Filho, Roberto Pecoits, Pereira, Márcio Antônio, Saporito, Wladmir, Scotton, Antonio Scafuto, Schuch, Tiago, de Almeida, Roberto Simões, Ramos, Cássio Slompo, Felício, João Soares, Thomé, Fernando, Hachmann, Jean Carlo Tibes, Yamada, Sérgio, Hayashida, Cesar Yoiti, Petry, Tarissa Beatrice Zanata, Zanella, Maria Teresa, Andreeva, Viktoria, Angelova, Angelina, Dimitrov, Stefan, Genadieva, Veselka, Genova-Hristova, Gabriela, Hristozov, Kiril, Kamenov, Zdravko, Koundurdjiev, Atanas, Lozanov, Lachezar, Margaritov, Viktor, Nonchev, Boyan, Rangelov, Rangel, Shinkov, Alexander, Temelkova, Margarita, Velichkova, Ekaterina, Yakov, Andrian, Aggarwal, Naresh, Aronson, Ronnie, Bajaj, Harpreet, Chouinard, Guy, Conway, James, Cournoyer, Serge, DaRoza, Gerald, De Serres, Sacha, Dubé, François, Goldenberg, Ronald, Gupta, Anil, Gupta, Milan, Henein, Sam, Khandwala, Hasnain, Leiter, Lawrence, Madore, François, McMahon, Alan, Muirhead, Norman, Pichette, Vincent, Rabasa-Lhoret, Remi, Steele, Andrew, Tangri, Navdeep, Torshizi, Ali, Woo, Vincent, Zalunardo, Nadia, Montenegro, María Alicia Fernández, Gonzalo Godoy Jorquera, Juan, Fariña, Marcelo Medina, Gajardo, Victor Saavedra, Vejar, Margarita, Chen, Nan, Chen, Qinkai, Gan, Shenglian, Kong, Yaozhong, Li, Detian, Li, Wenge, Li, Xuemei, Lin, Hongli, Liu, Jian, Lu, Weiping, Mao, Hong, Ren, Yan, Song, Weihong, Sun, Jiao, Sun, Lin, Tu, Ping, Wang, Guixia, Yang, Jinkui, Yin, Aiping, Yu, Xueqing, Zhao, Minghui, Zheng, Hongguang, Mendoza, Jose Luis Accini, Arcos, Edgar, Avendano, Jorge, Diaz Ruiz, Jorge Ernesto Andres, Ortiz, Luis Hernando Garcia, Gonzalez, Alexander, Triana, Eric Hernandez, Higuera, Juan Diego, Malaver, Natalia, de Salazar, Dora Inés Molina, Rosero, Ricardo, Alexandra Terront Lozano, Monica, Cometa, Luis Valderrama, Valenzuela, Alex, Vargas Alonso, Ruben Dario, Villegas, Ivan, Yupanqui, Hernan, Bartaskova, Dagmar, Barton, Petr, Belobradkova, Jana, Dohnalova, Lenka, Drasnar, Tomas, Ferkl, Richard, Halciakova, Katarina, Klokocnikova, Vera, Kovar, Richard, Lastuvka, Jiri, Lukac, Martin, Pesickova, Satu, Peterka, Karel, Pumprla, Jiri, Rychlik, Ivan, Saudek, Frantisek, Tesar, Vladimir, Valis, Martin, Weiner, Pavel, Zemek, Stanislav, Alamartine, Eric, Borot, Sophie, Cariou, Bertrand, Dussol, Bertrand, Fauvel, Jean-Pierre, Gourdy, Pierre, Klein, Alexandre, Le Meur, Yannick, Penfornis, Alfred, Roussel, Ronan, Saulnier, Pierre-Jean, Thervet, Eric, Zaoui, Philippe, Burst, Volker, Faghih, Markus, Faulmann, Grit, Haller, Hermann, Jerwan-Keim, Reinhold, Maxeiner, Stephan, Paschen, Björn, Plassmann, Georg, Rose, Ludger, Gonzalez Orellana, Ronaldo Arturo, Haase, Franklin Paul, Moreira Diaz, Juan Pablo, Ramirez Roca, Luis Alberto, Sánchez Arenales, Jose Antonio, Sanchez Polo, José Vicente, Juarez, Erick Turcios, Csecsei, Gyongyi, Csiky, Botond, Danos, Peter, Deak, Laszlo, Dudas, Mihaly, Harcsa, Eleonora, Keltai, Katalin, Keresztesi, Sandor, Kiss, Krisztian, Konyves, Laszlo, Major, Lajos, Mileder, Margit, Molnar, Marta, Mucsi, Janos, Oroszlan, Tamas, Ory, Ivan, Paragh, Gyorgy, Peterfai, Eva, Petro, Gizella, Revesz, Katalin, Takacs, Robert, Vangel, Sandor, Vasas, Szilard, Zsom, Marianna, Abraham, Oomman, Bhushan, Raju Sree, Deepak, Dewan, Edwin, Fernando M., Gopalakrishnan, Natarajan, Gracious, Noble, Hansraj, Alva, Jain, Dinesh, Keshavamurthy, C.B., Khullar, Dinesh, Manisha, Sahay, Peringat, Jayameena, Prasad, Narayan, Satyanarayana, Rao K., Sreedhar, Reddy, Sreelatha, Melemadathil, Sudhakar, Bhimavarapu, Chandra Vyasam, Ramesh, Bonadonna, Riccardo, Castellino, Pietro, Ceriello, Antonio, Chiovato, Luca, De Cosmo, Salvatore, Derosa, Giuseppe, Di Carlo, Alberto, Di Cianni, Graziano, Frascà, Giovanni, Fuiano, Giorgio, Gambaro, Giovanni, Garibotto, Giacomo, Giorda, Carlo, Malberti, Fabio, Mandreoli, Marcora, Mannucci, Edoardo, Orsi, Emanuela, Piatti, Piermarco, Santoro, Domenico, Sasso, Ferdinando Carlo, Serviddio, Gaetano, Stella, Andrea, Trevisan, Roberto, Veronelli, Anna Maria, Zanoli, Luca, Akiyama, Hitoshi, Aoki, Hiromi, Asano, Akimichi, Iitsuka, Tadashi, Kajiyama, Shizuo, Kashine, Susumu, Kawada, Toshio, Kodera, Takamoto, Kono, Hiroshi, Koyama, Kazunori, Kumeda, Yasuro, Miyauchi, Shozo, Mizuyama, Kazuyuki, Niiya, Tetsuji, Oishi, Hiroko, Ota, Satoshi, Sakakibara, Terue, Takai, Masahiko, Tomonaga, Osamu, Tsujimoto, Mitsuru, Wakasugi, Masakiyo, Wakida, Yasushi, Watanabe, Takayuki, Yamada, Masayo, Yanagida, Kazuhiro, Yanase, Toshihiko, Yumita, Wataru, Gaupsiene, Egle, Kozloviene, Dalia, Navickas, Antanas, Urbanaviciene, Egle, Abdul Ghani, Rohana, Kadir, Khalid Abdul, Ali, Norsiah, Che Yusof, Mohd Daud, Gan, Chye Lee, Ismail, Mastura, Kong, Wei Yen, Lam, Swee Win, Lee, Li Yuan, Loh, Chek Loong, Manocha, Anita Bhajan, Ng, Kee Sing, Ahmad, Nik Nur Fatnoon Nik, Ratnasingam, Vanassa, Shudim, Saiful Shahrizal Bin, Vengadasalam, Paranthaman, Abraira Munoz, Luis David, Salazar, Melchor Alpizar, Cruz, Juan Baas, Soto, Mario Burgos, Ramos, Jose Chevaile, Wong, Alfredo Chew, Correa Rotter, Jose Ricardo, Escalante, Tonatiu Diaz, Enriquez Sosa, Favio Edmundo, Lozano, Fernando Flores, Flota Cervera, Luis Fernando, Baron, Paul Frenk, Ballesteros, Cecilia Garcia, Gomez Rangel, Jose David, Herrera Jimenez, Luis Enrique, Irizar Santana, Sergio Saul, Flores, Fernando Jimenez, Molina, Hugo Laviada, Luna Ceballos, Rosa Isela, del Campo Blanco, Belia Martin, Franco, Guadalupe Morales, Moreno Loza, Oscar Tarsicio, Rocha, Cynthia Mustieles, Vera, Gregorio Obrador, Castellanos, Ricardo Orozco, Calcaneo, Juan Peralta, Reyes Rosano, Miguel Angel, Pattzi, Hiromi Rodriguez, Guzman, Juan Rosas, Rucker Joerg, Isabel Erika, Saavedra Sanchez, Sandra Berenice, Sanchez Mijangos, Jose Hector, Sanson, Pablo Serrano, Tamayo y Orozco, Juan Alfredo, Chavez, Eloisa Tellez, Cepeda, Alejandro Valdes, Carrillo, Luis Venegas, Mesa, Juan Villagordoa, Escobedo, Rolando Zamarripa, Baker, John, Noonan, Paul, Scott, Russell, Walker, Robert, Watson, Edward, Williams, Michael, Young, Simon, Abejuela, Zaynab, Agra, Jeimeen, Aquitania, Grace, Caringal, Clodoaido, Comia, Rhea Severina, Santos, Lalaine Delos, Gomez, Olivert, Jimeno, Cecilia, Tan, Gerry, Tolentino, Marsha, Yao, Christy, Yap, Yvette Ethel, Lallaine Ygpuara, Ma. Dovie, Bijata-Bronisz, Renata, Hotlos, Lucyna, Januszewicz, Andrzej, Kaczmarek, Barbara, Kaminska, Anna, Lazuka, Lech, Madej, Andrzej, Mazur, Stanislaw, Mlodawska-Choluj, Dorota, Nowicki, Michal, Orlowska-Kowalik, Grazyna, Popenda, Grazyna, Rewerska, Barbara, Sowinski, Dariusz, Angelescu, Liliana Monica, Anghel, Veronica, Avram, Rodica-Ioana, Busegeanu, Mihaela-Magdalena, Cif, Adriana, Cosma, Dana, Crisan, Carmen, Demian, Luiza Despina, Ferariu, Ioana Emilia, Halmagyi, Ildiko, Hancu, Nicolae, Munteanu, Mircea, Negru, Doru, Onaca, Adriana Gabriela, Petrica, Ligia, Popa, Amorin Remus, Ranetti, Aurelian-Emil, Serafinceanu, Cristian, Toarba, Cristina, Agafyina, Alina, Barbarash, Olga, Barysheva, Olga, Chizhov, Daniil, Dobronravov, Vladimir, Glinkina, Irina, Grineva, Elena, Khirmanov, Vladimir, Kolmakova, Elena, Koroleva, Tatiana, Kvitkova, Liudmila, Marasaev, Viacheslav, Mkrtumyan, Ashot, Morugova, Tatiana, Nagibovich, Galina, Nagibovich, Oleg, Nedogoda, Sergei, Osipova, Irina, Raskina, Tatiana, Samoylova, Yulia, Sazonova, Olga, Shamkhalova, Minara, Shutemova, Elena, Shwartz, Yuriy, Uriasyev, Oleg, Vorobyev, Sergey, Zateyshchikova, Anna, Zateyshshikov, Dmitry, Zykova, Tatyana, Antic, Slobodan, Djordjevic, Miodrag, Kendereski, Aleksandra, Lalic, Katarina, Lalic, Nebojsa, Popovic-Radinovic, Vesna, Babikova, Jana, Benusova, Olga, Buganova, Ingrid, Culak, Jan, Dzupina, Andrej, Dzuponova, Jana, Fulop, Peter, Ilavska, Adriana, Martinka, Emil, Ochodnicka, Zuzana, Pella, Daniel, Smatanova, Iveta, Ahmed, Fayzal, Badat, Aysha, Breedt, Johannes, Distiller, Lawrence, Govender, Vimladhevi, Govender, Ravendran, Joshi, Mukesh, Jurgens, Jaco, Latiff, Gulam, Lombard, Landman, Mookadam, Mohamed, Ngcakani, Nomangesi, Nortje, Hendrik, Oosthuizen, Helena, Pillay-Ramaya, Larisha, Prozesky, Hans, Reddy, Jeevren, Rheeder, Paul, Seeber, Mary, Cho, Young Min, Jeong, In-Kyung, Kim, Sin Gon, Kim, Yeong Hoon, Kwon, Hyuk-Sang, Kwon, Min Jeong, Lee, Byung-Wan, Lee, JungEun, Lee, Moon-Kyu, Nam, Moon-Suk, Oh, Kook-Hwan, Park, Cheol- Young, Park, Sun-Hee, Yoon, Kun Ho, Garcia, Pere Alvarez, Mercadal, Luis Asmarats, Barrios, Clara, Castro, Fernando Cereto, Guldris, Secundino Cigarran, Lopez, Marta Dominguez, Egido de los Rios, Jesus, Fresnedo, Gema Fernandez, Serrano, Antonio Galan, Garcia, Isabel, Gonzalez Martinez, Francisco Javier, Jodar Gimeno, Jose Esteban, Mendoza, Manuel Lopez, Marin, Tamara Malek, Portillo, Cristobal Morales, Munar Vila, Maria Antonia, Torres, Manuel Muñoz, Iglesias, Javier Nieto, Perez, Jonay Pantoja, Vera, Merce Perez, Portoles Perez, Jose M., Quesada Simón, María Angustias, Canonge, Rafael Simo, Gonzalez, Alfonso Soto, Riera, Manel Terns, Tinahones Madueno, Francisco Jose, Plaza, Mercedes Velo, Chang, Chwen-Tzuei, Chuang, Lee-Ming, Hsia, Te-Lin, Hsieh, Chang-Hsun, Lin, Chih-Ching, Lu, Yung- Chuan, Sheu, Wayne H-H, Barna, Olga, Bilyk, Svitlana D., Botsyurko, Volodymyr, Dudar, Iryna, Fushtey, Ivan, Godlevska, Olga, Golovchenko, Oleksandr, Gyrina, Olga, Kazmirchuk, Anatoliy, Komisarenko, Iuliia, Korzh, Oleksii, Kravchun, Nonna, Legun, Oleg, Mankovskyy, Borys, Martynyuk, Liliya, Mostovoy, Yuriy, Pashkovska, Nataliia, Pererva, Larysa, Pertseva, Tetyana, Samoylov, Oleksandr, Smirnov, Ivan, Svyshchenko, Yevgeniya, Tomashkevych, Halyna, Topchii, Ivan, Tryshchuk, Nadiya, Tseluyko, Vira, Vizir, Vadym, Vlasenko, Maryna, Zlova, Tetiana, Zub, Liliia, Abusnana, Salah, Railey, Mohamed, Abouglila, Kamal, Ainsworth, Paul, Ali, Zishan, Arutchelvam, Vijayaraman, Barnard, Maria, Bellary, Srikanth, Davies, Emyr, Davies, Mark, Davies, Simon, Dawson, Alison, El Kossi, Mohsen, English, Patrick, Fraser, Donald, Gnudi, Luigi, Gunstone, Anthony, Hall, Timothy, Hanif, Wasim, Jackson, Alan, Johnson, Andrew, Joseph, Franklin, Krishnan, Singhan, Kumwenda, Mick, MacDougall, Iain, Nixon, Paul, O'Hare, Joseph, Philip, Sam, Ramtoola, Shenaz, Saxena, Manish, Sennik, Davesh, Simon, Godwin, Singh, Baldev, Stephens, Jeffrey, Strzelecka, Anna, Symonds, Rehan, Turner, Wayne, Wahba, Mona, Wakeling, John, Wheeler, David, Winocour, Peter, Abdallah, Joseph, Abdullah, Raied, Abramowitz, Matthew, Acosta, Idalia, Aiello, Joseph, Akright, Laura, Akyea-Djamson, Ayim, Alappan, Rajendran, Alicic, Radica, Al-Karadsheh, Amer, Allison, Dale Crawford, Arauz-Pacheco, Carlos, Arfeen, Shahabul, Arif, Ahmed, Arvind, Moogali, Atray, Naveen, Awad, Ahmed, Barnhill, Peggy, Barranco, Elizabeth, Barrera, Carlos, Beacom, Matthew, Behara, Venkata, Belo, Diogo, Bentley-Lewis, Rhonda, Berenguer, Ramon, Bermudez, Lidia, Bernardo, Marializa, Biscoveanu, Mihaela, Bowman-Stroud, Cynthia, Brandon, Donald, Brusco, Osvaldo, Busch, Robert, Canaan, Yamil, Chilito, Alicia, Christensen, Tom, Christiano, Cynthia, Christofides, Elena, Chuateco, Caroucel, Cohen, Kenneth, Cohen, Robert, Cohen-Stein, Debbie, Cook, Charles, Coyne, Daniel, Daboul, Nizar, Darwish, Riad, Daswani, Adarsh, Deck, Kenneth, Desouza, Cyrus, Dev, Devasmita, Dhillon, Monika, Dua, Sohan, Eder, Frank, Elosegui, Ana Maria, El-Shahawy, Mohamed, Ervin, John, Esquenazi, Alberto, Evans, John, Fishbane, Steven, Frias, Juan, Galindo-Ramos, Eugenia, Galphin, Claude, Ghazi, Adline, Gonzalez, Enrique, Gorson, David, Gowda, Anupama, Greco, Barbara, Grubb, Stephen, Gulati, Rakesh, Hammoud, Jamal, Handelsman, Stuart, Hartman, Israel, Hershon, Kenneth, Hiser, Daniel, Hon, George, Jacob, Radu, Jaime, Maria, Jamal, Aamir, Kaupke, Charles, Keightley, Gerald, Kern, Elizabeth, Khanna, Rakhi, Khitan, Zeid, Kim, Sun, Kopyt, Nelson, Kovesdy, Csaba, Krishna, Gopal, Kropp, Jeffrey (Jay), Kumar, Amrendra, Kumar, Jayant, Kumar, Neil, Kusnir, Jorge, Lane, Wendy, Lawrence, Mary, Lehrner, Lawrence, Lentz, John, Levinson, Dennis, Lewis, Derek, Liss, Kenneth, Maddux, Andreas, Maheshwari, Hiralal, Mandayam, Sreedhar, Marar, Isam, Mehta, Bhasker, Middleton, John, Mordujovich, Jorge, Moreda, Ramon, Moustafa, Moustafa, Trenche, Samuel Mujica, Narayanan, Mohanram, Narvarte, Javier, Nassar, Tareq, Newman, George, Nichol, Brian, Nicol, Philip, Nisnisan, Josier, Nossuli, A. Kaldun, Obialo, Chamberlain, Olelewe, Sarah, Oliver, Michael, O'Shaughnessy, Andrew, Padron, John, Pankhaniya, Rohit, Parker, Reginald, Patel, Devesh, Patel, Gnyandev, Patel, Nina, Pavon, Humberto, Perez, Armando, Perez, Carlos, Perlman, Alan, Pettis, Karlton, Pharr, Walter, Phillips, Andrea, Purighalla, Raman, Quesada-Suarez, Luis, Ranjan, Rajiv, Rastogi, Sanjeev, Reddy, Jakkidi, Rendell, Marc, Rich, Lisa, Robinson, Michael, Rodriguez, Hector, Rosas, Sylvia, Saba, Fadi, Sankaram, Rallabhandi, Sarin, Ravi, Schreiman, Robert, Scott, David, Sekkarie, Mohamed, Sensenbrenner, John, Shakeel, Muhammad, Shanik, Michael, Shaw, Sylvia, Smith, Stephen, Solomon, Richard, Sprague, Amy, Spry, Leslie, Suchinda, Pusadee, Sultan, Senan, Surampudi, Prasanth, Sussman, Sherry, Tan, Anjanette, Terrelonge, Antonio, Thompson, Michael, Trespalacios, Fernando, Trippe, Bruce, Trueba, Pilar, Twahirwa, Marcel, Updegrove, John, Van Buren, Peter, Vannorsdall, Mark, Varghese, Freemu, Velasquez-Mieyer, Pedro, Ventrapragada, Sailaja, Vukotic, Goga, Wadud, Khurram, Warren, Mark, Watson, Henry, Watts, Ronald, Weiner, Daniel, Welker, James, Welsh, Jean, Williams, Shelley, Zaniewski-Singh, Michelle, Yi, Tae Won, Smyth, Brendan, Di Tanna, Gian Luca, Arnott, Clare, Cardoza, Kathryn, and Kang, Amy

Published
2023
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15. Homework: Facts and Fiction

Author

Fernández-Alonso, Rubén, Muñiz, José, Scherer, Ronny, Section editor, Nilsen, Trude, editor, Stancel-Piątak, Agnes, editor, and Gustafsson, Jan-Eric, editor

Published
2022
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18. Human-centric artificial intelligence architecture for industry 5.0 applications.

Author

Rožanec, Jože M., Novalija, Inna, Zajec, Patrik, Kenda, Klemen, Tavakoli Ghinani, Hooman, Suh, Sungho, Veliou, Entso, Papamartzivanos, Dimitrios, Giannetsos, Thanassis, Menesidou, Sofia Anna, Alonso, Ruben, Cauli, Nino, Meloni, Antonello, Recupero, Diego Reforgiato, Kyriazis, Dimosthenis, Sofianidis, Georgios, Theodoropoulos, Spyros, Fortuna, Blaž, Mladenić, Dunja, and Soldatos, John

Subjects
ARTIFICIAL intelligence, ACTIVE learning, TRUST, BIG data, MANUFACTURING industries
Abstract

Human-centricity is the core value behind the evolution of manufacturing towards Industry 5.0. Nevertheless, there is a lack of architecture that considers safety, trustworthiness, and human-centricity at its core. Therefore, we propose an architecture that integrates Artificial Intelligence (Active Learning, Forecasting, Explainable Artificial Intelligence), simulated reality, decision-making, and users' feedback, focussing on synergies between humans and machines. Furthermore, we align the proposed architecture with the Big Data Value Association Reference Architecture Model. Finally, we validate it on three use cases from real-world case studies. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Valoración de Tratamientos Orgánicos para el Control de Mosquita Blanca (Bemisia tabaci) en Habanero (Capsicum chinense) a Campo Abierto

Author

Pérez López, Emanuel, Bolaños Virgen, Lorena Guadalupe, Muraira Soto, Mercedes, Aguirre Alonso, Ruben Onofre, Rodriguez Roy, Sergio, Pérez López, Emanuel, Bolaños Virgen, Lorena Guadalupe, Muraira Soto, Mercedes, Aguirre Alonso, Ruben Onofre, and Rodriguez Roy, Sergio

Abstract

The research project was carried out with the purpose of evaluating organic treatments for the control of the whitefly (Bemisia tabaci) in the cultivation of habanero chili (Capsicum chinense) through homemade and economic methods; Using principles of agroecology, in order to reduce the gap of dependence on chemical products in the primary inputs of agricultural production, the first method consisted of sulfocalcium broth, a product used mainly as a fungicide, applied to the leaves of the crop to eliminate pests; The second was the repellent based on oregano (Origanum vulgare Mill) applied foliarly. The test consisted of three treatments with the control, with 80 repetitions (plants) of each one, developed in an experimental design in completely random plots, to the results obtained an analysis of variance and a Tukey pass with 0.95 were applied. reliability; developed in InfoStat v. 2022 where, the control and repellency results showed that the treatments are different; and in production, the oregano repellent (T2) showed a statistical difference compared to the other two treatments, so the null hypothesis is rejected and the alternative hypothesis is accepted., El proyecto de investigación se realizó con el propósito de evaluar tratamientos orgánicos para el control de la mosquita blanca (Bemisia tabaci) en el cultivo de chile habanero (Capsicum chinense) a través de métodos caseros y económicos; empleando principios de agroecología, con el fin de reducir la brecha de la dependencia de productos químicos en los insumos primarios de la producción agrícola, el primer método consistió en el caldo sulfocálcico, un producto utilizado principalmente como fungicida, aplicado en hojas del cultivo para eliminar plagas; el segundo fue el repelente a base de orégano (Origanum vulgare Mill) aplicado de manera foliar. El ensayo consistió en tres tratamientos con el testigo, con 80 repeticiones (plantas) de cada uno, desarrollado en un diseño experimental en parcelas completamente al azar, a los resultados obtenidos se les aplicó un análisis de varianza y un aprueba de Tukey con 0.95 de confiabilidad; desarrollado en InfoStat v. 2022 en donde, los resultados de control y repelencia mostraron que los tratamientos son diferentes; y en la producción, el repelente de orégano (T2) mostró una diferencia estadística respecto a los otros dos tratamientos, por lo que se rechaza la hipótesis nula y se acepta la hipótesis alternativa.

Published
2024

26. Control of the E2REBOT Platform for Upper Limb Rehabilitation in Patients with Neuromotor Impairment

Author

Fraile, Juan-Carlos, Pérez-Turiel, Javier, Viñas, Pablo, Alonso, Rubén, Cuadrado, Alejandro, Ayuso, Laureano, García-Bravo, Francisco, Nieto, Felix, Mihai, Laurentiu, Franco-Martin, Manuel, Kacprzyk, Janusz, Series editor, Reis, Luís Paulo, editor, Moreira, António Paulo, editor, Lima, Pedro U., editor, Montano, Luis, editor, and Muñoz-Martinez, Victor, editor

Published
2016
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27. Impacto de la capacitación a los productores agropecuarios de la Cuenca del Papaloapan

Author

Pérez López, Emanuel, Maroto Pérez, Yesenia, Muraira Soto, Mercedes, Aguirre Alonso, Ruben Onofre, Rodriguez Roy, Sergio, Contreras Cisneros, Juan Carlos, Pérez López, Emanuel, Maroto Pérez, Yesenia, Muraira Soto, Mercedes, Aguirre Alonso, Ruben Onofre, Rodriguez Roy, Sergio, and Contreras Cisneros, Juan Carlos

Abstract

Mexico, in 2018, ranked tenth in population worldwide, with 125.3 million people, projecting that by 2050 there will be 148.2 million inhabitants. Given this, the Government of the Mexican Republic through the Secretaria de Agricultura y Desarrollo Rural (SADER) created strategic programs to generate momentum in the countryside, support and technical assistance to small and medium-sized primary producers, based on the Plan Nacional de Desarrollo (PND) 2019-2024 whose main objective is to achieve the well-being of the population. In the Papaloapan Basin, technical support has been for basic crops, fruit trees, vegetables and animal species of economic importance. Therefore, a qualitative investigation was proposed with the hypothesis that there is no perceptual difference between producers who implemented technical assistance and those who did not, a survey was carried out randomly in 16 communities of the Papaloapan Basin, resulting in that since 2020 there has been training, that agricultural units are considered profitable and that there is a difference between producers with and without technical assistance and support, especially in the certification of production processes and marketing channels, presenting greater problems. producers without assistance., México, en 2018, ocupaba el décimo lugar en población a nivel mundial, con 125.3 millones de personas, proyectando que para 2050 existiremos 148.2 millones de habitantes. Ante esto, el Gobierno de la República Mexicana mediante la Secretaría de Agricultura y Desarrollo Rural (SADER) creó programas estratégicos para generar el impulso al campo, de apoyo y asistencia técnica a pequeños y medianos productores primarios, basados en el Plan Nacional de Desarrollo (PND) 2019-2024 cuyo principal objetivo en lograr el bienestar de la población. En la Cuenca del Papaloapan, el acompañamiento técnico ha sido a cultivos básicos, frutales, hortícolas y, especies animales de importancia económica. Por lo que, se planteó una investigación cualitativa con la hipótesis de que no existe diferencia perceptiva entre los productores que implementaron asistencia técnica y los que no, se realizó una encuesta de manera aleatoria en 16 comunidades de la Cuenca del Papaloapan, arrojando como resultado que desde 2020 existe capacitación, que se consideran las unidades agropecuarias como rentables y que sí existe diferencia entre los productores con y sin asistencia y acompañamiento técnico, sobre todo en la certificación de procesos productivos y canales de comercialización, presentando mayores problema los productores sin asistencia.

Published
2023

30. D8.5 SPHERE workshop series and training

Author

Salces, Fausto Sainz, Soley, Gisela, Zerpa, Veronica, Borras, Mikel, Lodigiani, Alejandro, and Alonso, Ruben

Subjects
workshop, training activities
Abstract

Description of the Sphere workshops for stakeholders that will be held from now until the end of the project. Description of the internal & external training activities that will be organised during the project. &nbsp

Published
2023
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32. Human-centric artificial intelligence architecture for industry 5.0 applications

Author

Rožanec, Jože M., primary, Novalija, Inna, additional, Zajec, Patrik, additional, Kenda, Klemen, additional, Tavakoli Ghinani, Hooman, additional, Suh, Sungho, additional, Veliou, Entso, additional, Papamartzivanos, Dimitrios, additional, Giannetsos, Thanassis, additional, Menesidou, Sofia Anna, additional, Alonso, Ruben, additional, Cauli, Nino, additional, Meloni, Antonello, additional, Recupero, Diego Reforgiato, additional, Kyriazis, Dimosthenis, additional, Sofianidis, Georgios, additional, Theodoropoulos, Spyros, additional, Fortuna, Blaž, additional, Mladenić, Dunja, additional, and Soldatos, John, additional

Published
2022
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34. Imfirst: A phase IIIb, safety, single arm study of carboplatin (CB) or cisplatin (CP) plus etoposide (ET) with atezolizumab (ATZ) in patients with untreated extensive-stage small cell lung cancer (ES-SCLC) in Spain—Primary safety results of the induction phase.

Author

García Campelo, Maria Rosario, primary, Domine, Manuel, additional, De Castro, Javier, additional, Moreno, Alberto, additional, Ponce Aix, Santiago, additional, Arriola, Edurne, additional, Carcereny, Enric, additional, Majem, Margarita, additional, Huidobro Vence, Gerardo, additional, Esteban, Emilio, additional, Fuentes Pradera, Jose, additional, Massuti, Bartomeu, additional, Ortega, Ana Laura, additional, Mónica, Guillot, additional, Cordoba, Juan Felipe, additional, Fernandez, Natalia, additional, Alonso, Ruben, additional, Crama, Leonardo, additional, Lerones, Natalia, additional, and Cobo, Manuel, additional

Published
2021
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35. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease

Author

Zhou, Zien, primary, Jardine, Meg J., additional, Li, Qiang, additional, Neuen, Brendon L., additional, Cannon, Christopher P., additional, de Zeeuw, Dick, additional, Edwards, Robert, additional, Levin, Adeera, additional, Mahaffey, Kenneth W., additional, Perkovic, Vlado, additional, Neal, Bruce, additional, Lindley, Richard I., additional, Ahuad Guerrero, Rodolfo Andres, additional, Aizenberg, Diego, additional, Albisu, Juan Pablo, additional, Alvarisqueta, Andres, additional, Bartolacci, Ines, additional, Berli, Mario Alberto, additional, Bordonava, Anselmo, additional, Calella, Pedro, additional, Cantero, Maria Cecilia, additional, Cartasegna, Luis Rodolfo, additional, Cercos, Esteban, additional, Coloma, Gabriela Cecilia, additional, Colombo, Hugo, additional, Commendatore, Victor, additional, Cuadrado, Jesus, additional, Cuneo, Carlos Alberto, additional, Cusumano, Ana Maria, additional, Douthat, Walter Guillermo, additional, Dran, Ricardo Dario, additional, Farias, Eduardo, additional, Fernandez, Maria Florencia, additional, Finkelstein, Hernan, additional, Fragale, Guillermo, additional, Fretes, Jose Osvaldo, additional, Garcia, Nestor Horacio, additional, Gastaldi, Anibal, additional, Gelersztein, Elizabeth, additional, Glenny, Jorge Archibaldo, additional, Gonzalez, Joaquin Pablo, additional, del Carmen Gonzalez Colaso, Patricia, additional, Goycoa, Claudia, additional, Greloni, Gustavo Cristian, additional, Guinsburg, Adrian, additional, Hermida, Sonia, additional, Juncos, Luis Isaias, additional, Klyver, Maria Isabel, additional, Kraft, Florencia, additional, Krynski, Fernando, additional, Lanchiotti, Paulina Virginia, additional, Leon de la Fuente, Ricardo Alfonso, additional, Marchetta, Nora, additional, Mele, Pablo, additional, Nicolai, Silvia, additional, Novoa, Pablo Antonio, additional, Orio, Silvia Ines, additional, Otreras, Fabian, additional, Oviedo, Alejandra, additional, Raffaele, Pablo, additional, Resk, Jorge Hector, additional, Rista, Lucas, additional, Rodriguez Papini, Nelson, additional, Sala, Jorgelina, additional, Santos, Juan Carlos, additional, Schiavi, Lilia Beatriz, additional, Sessa, Horacio, additional, Smith Casabella, Tomas, additional, Ulla, Maria Rosa, additional, Valdez, Maria, additional, Vallejos, Augusto, additional, Villarino, Adriana, additional, Visco, Virginia Esther, additional, Wassermann, Alfredo, additional, Zaidman, Cesar Javier, additional, Cheung, Ngai Wah, additional, Droste, Carolyn, additional, Fraser, Ian, additional, Johnson, David, additional, Mah, Peak Mann, additional, Nicholls, Kathy, additional, Packham, David, additional, Proietto, Joseph, additional, Roberts, Anthony, additional, Roger, Simon, additional, Tsang, Venessa, additional, Abrão Raduan, Roberto, additional, Alves da Costa, Fernando Augusto, additional, Amodeo, Celso, additional, Andreotti Turatti, Luiz Alberto, additional, Bregman, Rachel, additional, Camelo Sanches, Fernanda Cristina, additional, Canani, Luis Henrique, additional, Chacra, Antônio Roberto, additional, Cunha Borges, João Lindolfo, additional, Cunha Vêncio, Sérgio Alberto, additional, da Silva Franco, Roberto Jorge, additional, d’Avila, Domingos, additional, de Souza Portes, Evandro, additional, de Souza, Pedro, additional, Deboni, Luciane Mônica, additional, Fraige Filho, Fadlo, additional, Geloneze Neto, Bruno, additional, Gomes, Marcus, additional, Keiko Kohara, Suely, additional, Keitel, Elizete, additional, Kerr Saraiva, Jose Francisco, additional, Kurtz Lisboa, Hugo Roberto, additional, Loss de Carvalho Contieri, Fabiana, additional, Milagres, Rosângela, additional, Montenegro Junior, Renan, additional, Moreira de Brito, Claudia, additional, Nasser Hissa, Miguel, additional, Nazario Sabbag, Ângela Regina, additional, Noronha, Irene, additional, Panarotto, Daniel, additional, Pecoits Filho, Roberto, additional, Pereira, Márcio Antônio, additional, Saporito, Wladmir, additional, Scafuto Scotton, Antonio, additional, Schuch, Tiago, additional, Simões de Almeida, Roberto, additional, Slompo Ramos, Cássio, additional, Soares Felício, João, additional, Thomé, Fernando, additional, Tibes Hachmann, Jean Carlo, additional, Yamada, Sérgio, additional, Yoiti Hayashida, Cesar, additional, Zanata Petry, Tarissa Beatrice, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoria, additional, Angelova, Angelina, additional, Dimitrov, Stefan, additional, Genadieva, Veselka, additional, Genova-Hristova, Gabriela, additional, Hristozov, Kiril, additional, Kamenov, Zdravko, additional, Koundurdjiev, Atanas, additional, Lozanov, Lachezar, additional, Margaritov, Viktor, additional, Nonchev, Boyan, additional, Rangelov, Rangel, additional, Shinkov, Alexander, additional, Temelkova, Margarita, additional, Velichkova, Ekaterina, additional, Yakov, Andrian, additional, Aggarwal, Naresh, additional, Aronson, Ronnie, additional, Bajaj, Harpreet, additional, Cherney, David, additional, Chouinard, Guy, additional, Conway, James, additional, Cournoyer, Serge, additional, DaRoza, Gerald, additional, De Serres, Sacha, additional, Dubé, François, additional, Goldenberg, Ronald, additional, Gupta, Anil, additional, Gupta, Milan, additional, Henein, Sam, additional, Khandwala, Hasnain, additional, Leiter, Lawrence, additional, Madore, François, additional, McMahon, Alan, additional, Muirhead, Norman, additional, Pichette, Vincent, additional, Rabasa-Lhoret, Remi, additional, Steele, Andrew, additional, Tangri, Navdeep, additional, Torshizi, Ali, additional, Woo, Vincent, additional, Zalunardo, Nadia, additional, Fernández Montenegro, María Alicia, additional, Godoy Jorquera, Juan Gonzalo, additional, Medina Fariña, Marcelo, additional, Saavedra Gajardo, Victor, additional, Vejar, Margarita, additional, Chen, Nan, additional, Chen, Qinkai, additional, Gan, Shenglian, additional, Kong, Yaozhong, additional, Li, Detian, additional, Li, Wenge, additional, Li, Xuemei, additional, Lin, Hongli, additional, Liu, Jian, additional, Lu, Weiping, additional, Mao, Hong, additional, Ren, Yan, additional, Song, Weihong, additional, Sun, Jiao, additional, Sun, Lin, additional, Tu, Ping, additional, Wang, Guixia, additional, Yang, Jinkui, additional, Yin, Aiping, additional, Yu, Xueqing, additional, Zhao, Minghui, additional, Zheng, Hongguang, additional, Accini Mendoza, Jose Luis, additional, Arcos, Edgar, additional, Avendano, Jorge, additional, Diaz Ruiz, Jorge Ernesto Andres, additional, Garcia Ortiz, Luis Hernando, additional, Gonzalez, Alexander, additional, Hernandez Triana, Eric, additional, Higuera, Juan Diego, additional, Malaver, Natalia, additional, Molina de Salazar, Dora Inés, additional, Rosero, Ricardo, additional, Terront Lozano, Monica Alexandra, additional, Valderrama Cometa, Luis, additional, Valenzuela, Alex, additional, Vargas Alonso, Ruben Dario, additional, Villegas, Ivan, additional, Yupanqui, Hernan, additional, Bartaskova, Dagmar, additional, Barton, Petr, additional, Belobradkova, Jana, additional, Dohnalova, Lenka, additional, Drasnar, Tomas, additional, Ferkl, Richard, additional, Halciakova, Katarina, additional, Klokocnikova, Vera, additional, Kovar, Richard, additional, Lastuvka, Jiri, additional, Lukac, Martin, additional, Pesickova, Satu, additional, Peterka, Karel, additional, Pumprla, Jiri, additional, Rychlik, Ivan, additional, Saudek, Frantisek, additional, Tesar, Vladimir, additional, Valis, Martin, additional, Weiner, Pavel, additional, Zemek, Stanislav, additional, Alamartine, Eric, additional, Borot, Sophie, additional, Cariou, Bertrand, additional, Dussol, Bertrand, additional, Fauvel, Jean-Pierre, additional, Gourdy, Pierre, additional, Klein, Alexandre, additional, Le Meur, Yannick, additional, Penfornis, Alfred, additional, Roussel, Ronan, additional, Saulnier, Pierre-Jean, additional, Thervet, Eric, additional, Zaoui, Philippe, additional, Burst, Volker, additional, Faghih, Markus, additional, Faulmann, Grit, additional, Haller, Hermann, additional, Jerwan-Keim, Reinhold, additional, Maxeiner, Stephan, additional, Paschen, Björn, additional, Plassmann, Georg, additional, Rose, Ludger, additional, Gonzalez Orellana, Ronaldo Arturo, additional, Haase, Franklin Paul, additional, Moreira Diaz, Juan Pablo, additional, Ramirez Roca, Luis Alberto, additional, Sánchez Arenales, Jose Antonio, additional, Sanchez Polo, José Vicente, additional, Turcios Juarez, Erick, additional, Csecsei, Gyongyi, additional, Csiky, Botond, additional, Danos, Peter, additional, Deak, Laszlo, additional, Dudas, Mihaly, additional, Harcsa, Eleonora, additional, Keltai, Katalin, additional, Keresztesi, Sandor, additional, Kiss, Krisztian, additional, Konyves, Laszlo, additional, Major, Lajos, additional, Mileder, Margit, additional, Molnar, Marta, additional, Mucsi, Janos, additional, Oroszlan, Tamas, additional, Ory, Ivan, additional, Paragh, Gyorgy, additional, Peterfai, Eva, additional, Petro, Gizella, additional, Revesz, Katalin, additional, Takacs, Robert, additional, Vangel, Sandor, additional, Vasas, Szilard, additional, Zsom, Marianna, additional, Oomman, Abraham, additional, Raju, Sree Bhushan, additional, Dewan, Deepak, additional, Fernando, M. Edwin, additional, Gopalakrishnan, Natarajan, additional, Gracious, Noble, additional, Alva, Hansraj, additional, Jain, Dinesh, additional, Keshavamurthy, C. B., additional, Khullar, Dinesh, additional, Sahay, Manisha, additional, Peringat, Jayameena, additional, Prasad, Narayan, additional, Rao, K. Satyanarayana, additional, Reddy, Sreedhar, additional, Melemadathil, Sreelatha, additional, Sudhakar, Bhimavarapu, additional, Vyasam, Ramesh Chandra, additional, Bonadonna, Riccardo, additional, Castellino, Pietro, additional, Ceriello, Antonio, additional, Chiovato, Luca, additional, De Cosmo, Salvatore, additional, De Nicola, Luca, additional, Derosa, Giuseppe, additional, Di Carlo, Alberto, additional, Di Cianni, Graziano, additional, Frascà, Giovanni, additional, Fuiano, Giorgio, additional, Gambaro, Giovanni, additional, Garibotto, Giacomo, additional, Giorda, Carlo, additional, Malberti, Fabio, additional, Mandreoli, Marcora, additional, Mannucci, Edoardo, additional, Orsi, Emanuela, additional, Piatti, Piermarco, additional, Santoro, Domenico, additional, Sasso, Ferdinando Carlo, additional, Serviddio, Gaetano, additional, Stella, Andrea, additional, Trevisan, Roberto, additional, Veronelli, Anna Maria, additional, Zanoli, Luca, additional, Akiyama, Hitoshi, additional, Aoki, Hiromi, additional, Asano, Akimichi, additional, Iitsuka, Tadashi, additional, Kajiyama, Shizuo, additional, Kashine, Susumu, additional, Kawada, Toshio, additional, Kodera, Takamoto, additional, Kono, Hiroshi, additional, Koyama, Kazunori, additional, Kumeda, Yasuro, additional, Miyauchi, Shozo, additional, Mizuyama, Kazuyuki, additional, Niiya, Tetsuji, additional, Oishi, Hiroko, additional, Ota, Satoshi, additional, Sakakibara, Terue, additional, Takai, Masahiko, additional, Tomonaga, Osamu, additional, Tsujimoto, Mitsuru, additional, Wada, Takashi, additional, Wakasugi, Masakiyo, additional, Wakida, Yasushi, additional, Watanabe, Takayuki, additional, Yamada, Masayo, additional, Yanagida, Kazuhiro, additional, Yanase, Toshihiko, additional, Yumita, Wataru, additional, Gaupsiene, Egle, additional, Kozloviene, Dalia, additional, Navickas, Antanas, additional, Urbanaviciene, Egle, additional, Abdul Ghani, Rohana, additional, Abdul Kadir, Khalid, additional, Ali, Norsiah, additional, Che Yusof, Mohd Daud, additional, Gan, Chye Lee, additional, Ismail, Mastura, additional, Kong, Wei Yen, additional, Lam, Swee Win, additional, Lee, Li Yuan, additional, Lim, Soo Kun, additional, Loh, Chek Loong, additional, Manocha, Anita Bhajan, additional, Ng, Kee Sing, additional, Nik Ahmad, Nik Nur Fatnoon, additional, Ratnasingam, Vanassa, additional, Shudim, Saiful Shahrizal Bin, additional, Vengadasalam, Paranthaman, additional, Abraira Munoz, Luis David, additional, Alpizar Salazar, Melchor, additional, Baas Cruz, Juan, additional, Burgos Soto, Mario, additional, Chevaile Ramos, Jose, additional, Chew Wong, Alfredo, additional, Correa Rotter, Jose Ricardo, additional, Diaz Escalante, Tonatiu, additional, Enriquez Sosa, Favio Edmundo, additional, Flores Lozano, Fernando, additional, Flota Cervera, Luis Fernando, additional, Frenk Baron, Paul, additional, Garcia Ballesteros, Cecilia, additional, Gomez Rangel, Jose David, additional, Herrera Jimenez, Luis Enrique, additional, Irizar Santana, Sergio Saul, additional, Jimenez Flores, Fernando, additional, Laviada Molina, Hugo, additional, Luna Ceballos, Rosa Isela, additional, Martin del Campo Blanco, Belia, additional, Morales Franco, Guadalupe, additional, Moreno Loza, Oscar Tarsicio, additional, Mustieles Rocha, Cynthia, additional, Obrador Vera, Gregorio, additional, Orozco Castellanos, Ricardo, additional, Peralta Calcaneo, Juan, additional, Reyes Rosano, Miguel Angel, additional, Rodriguez Pattzi, Hiromi, additional, Rosas Guzman, Juan, additional, Rucker Joerg, Isabel Erika, additional, Saavedra Sanchez, Sandra Berenice, additional, Sanchez Mijangos, Jose Hector, additional, Serrano Sanson, Pablo, additional, Tamayo y Orozco, Juan Alfredo, additional, Tellez Chavez, Eloisa, additional, Valdes Cepeda, Alejandro, additional, Venegas Carrillo, Luis, additional, Villagordoa Mesa, Juan, additional, Zamarripa Escobedo, Rolando, additional, Baker, John, additional, Noonan, Paul, additional, Scott, Russell, additional, Walker, Robert, additional, Watson, Edward, additional, Williams, Michael, additional, Young, Simon, additional, Abejuela, Zaynab, additional, Agra, Jeimeen, additional, Aquitania, Grace, additional, Caringal, Clodoaido, additional, Comia, Rhea Severina, additional, Delos Santos, Lalaine, additional, Gomez, Olivert, additional, Jimeno, Cecilia, additional, Santos, Florence, additional, Tan, Gerry, additional, Tolentino, Marsha, additional, Yao, Christy, additional, Yap, Yvette Ethel, additional, Ygpuara, Ma. Dovie Lallaine, additional, Bijata-Bronisz, Renata, additional, Hotlos, Lucyna, additional, Januszewicz, Andrzej, additional, Kaczmarek, Barbara, additional, Kaminska, Anna, additional, Lazuka, Lech, additional, Madej, Andrzej, additional, Mazur, Stanislaw, additional, Mlodawska-Choluj, Dorota, additional, Nowicki, Michal, additional, Orlowska-Kowalik, Grazyna, additional, Popenda, Grazyna, additional, Rewerska, Barbara, additional, Sowinski, Dariusz, additional, Angelescu, Liliana Monica, additional, Anghel, Veronica, additional, Avram, Rodica-Ioana, additional, Busegeanu, Mihaela-Magdalena, additional, Cif, Adriana, additional, Cosma, Dana, additional, Crisan, Carmen, additional, Demian, Luiza Despina, additional, Ferariu, Ioana Emilia, additional, Halmagyi, Ildiko, additional, Hancu, Nicolae, additional, Munteanu, Mircea, additional, Negru, Doru, additional, Onaca, Adriana Gabriela, additional, Petrica, Ligia, additional, Popa, Amorin Remus, additional, Ranetti, Aurelian-Emil, additional, Serafinceanu, Cristian, additional, Toarba, Cristina, additional, Agafyina, Alina, additional, Barbarash, Olga, additional, Barysheva, Olga, additional, Chizhov, Daniil, additional, Dobronravov, Vladimir, additional, Dreval, Alexander, additional, Glinkina, Irina, additional, Grineva, Elena, additional, Khirmanov, Vladimir, additional, Kolmakova, Elena, additional, Koroleva, Tatiana, additional, Kvitkova, Liudmila, additional, Marasaev, Viacheslav, additional, Mkrtumyan, Ashot, additional, Morugova, Tatiana, additional, Nagibovich, Galina, additional, Nagibovich, Oleg, additional, Nedogoda, Sergei, additional, Osipova, Irina, additional, Raskina, Tatiana, additional, Samoylova, Yulia, additional, Sazonova, Olga, additional, Shamkhalova, Minara, additional, Shutemova, Elena, additional, Shwartz, Yuriy, additional, Uriasyev, Oleg, additional, Vorobyev, Sergey, additional, Zateyshchikova, Anna, additional, Zateyshshikov, Dmitry, additional, Zykova, Tatyana, additional, Antic, Slobodan, additional, Djordjevic, Miodrag, additional, Kendereski, Aleksandra, additional, Lalic, Katarina, additional, Lalic, Nebojsa, additional, Popovic-Radinovic, Vesna, additional, Babikova, Jana, additional, Benusova, Olga, additional, Buganova, Ingrid, additional, Culak, Jan, additional, Dzupina, Andrej, additional, Dzuponova, Jana, additional, Fulop, Peter, additional, Ilavska, Adriana, additional, Martinka, Emil, additional, Ochodnicka, Zuzana, additional, Pella, Daniel, additional, Smatanova, Iveta, additional, Ahmed, Fayzal, additional, Badat, Aysha, additional, Breedt, Johannes, additional, Distiller, Lawrence, additional, Govender, Vimladhevi, additional, Govender, Ravendran, additional, Joshi, Mukesh, additional, Jurgens, Jaco, additional, Latiff, Gulam, additional, Lombard, Landman, additional, Mookadam, Mohamed, additional, Ngcakani, Nomangesi, additional, Nortje, Hendrik, additional, Oosthuizen, Helena, additional, Pillay-Ramaya, Larisha, additional, Prozesky, Hans, additional, Reddy, Jeevren, additional, Rheeder, Paul, additional, Seeber, Mary, additional, Chae, Dong-Wan, additional, Cho, Young Min, additional, Jeong, In-Kyung, additional, Kim, Sin Gon, additional, Kim, Yeong Hoon, additional, Kwon, Hyuk-Sang, additional, Kwon, Min Jeong, additional, Lee, Byung-Wan, additional, Lee, JungEun, additional, Lee, Moon-Kyu, additional, Nam, Moon-Suk, additional, Oh, Kook-Hwan, additional, Park, Cheol-Young, additional, Park, Sun-Hee, additional, Yoon, Kun Ho, additional, Alvarez Garcia, Pere, additional, Asmarats Mercadal, Luis, additional, Barrios, Clara, additional, Cereto Castro, Fernando, additional, Cigarran Guldris, Secundino, additional, Dominguez Lopez, Marta, additional, Egido de los Rios, Jesus, additional, Fernandez Fresnedo, Gema, additional, Galan Serrano, Antonio, additional, Garcia, Isabel, additional, Gonzalez Martinez, Francisco Javier, additional, Jodar Gimeno, Jose Esteban, additional, Lopez Mendoza, Manuel, additional, Malek Marin, Tamara, additional, Morales Portillo, Cristobal, additional, Munar Vila, Maria Antonia, additional, Muñoz Torres, Manuel, additional, Nieto Iglesias, Javier, additional, Pantoja Perez, Jonay, additional, Perez Vera, Merce, additional, Portoles Perez, Jose Mª, additional, Quesada Simón, María Angustias, additional, Simo Canonge, Rafael, additional, Soto Gonzalez, Alfonso, additional, Terns Riera, Manel, additional, Tinahones Madueno, Francisco Jose, additional, Velo Plaza, Mercedes, additional, Chang, Chwen-Tzuei, additional, Chuang, Lee-Ming, additional, Hsia, Te-Lin, additional, Hsieh, Chang-Hsun, additional, Hwang, Shang-Jyh, additional, Lin, Chih-Ching, additional, Lu, Yung-Chuan, additional, Sheu, Wayne H-H, additional, Barna, Olga, additional, Bilyk, Svitlana D., additional, Botsyurko, Volodymyr, additional, Dudar, Iryna, additional, Fushtey, Ivan, additional, Godlevska, Olga, additional, Golovchenko, Oleksandr, additional, Gyrina, Olga, additional, Kazmirchuk, Anatoliy, additional, Kolesnyk, Mykola, additional, Komisarenko, Iuliia, additional, Korzh, Oleksii, additional, Kravchun, Nonna, additional, Legun, Oleg, additional, Mankovskyy, Borys, additional, Martynyuk, Liliya, additional, Mostovoy, Yuriy, additional, Pashkovska, Nataliia, additional, Pererva, Larysa, additional, Pertseva, Tetyana, additional, Samoylov, Oleksandr, additional, Smirnov, Ivan, additional, Svyshchenko, Yevgeniya, additional, Tomashkevych, Halyna, additional, Topchii, Ivan, additional, Tryshchuk, Nadiya, additional, Tseluyko, Vira, additional, Vizir, Vadym, additional, Vlasenko, Maryna, additional, Zlova, Tetiana, additional, Zub, Liliia, additional, Abusnana, Salah, additional, Railey, Mohamed, additional, Abouglila, Kamal, additional, Ainsworth, Paul, additional, Ali, Zishan, additional, Arutchelvam, Vijayaraman, additional, Barnard, Maria, additional, Bellary, Srikanth, additional, Davies, Emyr, additional, Davies, Mark, additional, Davies, Simon, additional, Dawson, Alison, additional, El Kossi, Mohsen, additional, English, Patrick, additional, Fraser, Donald, additional, Gnudi, Luigi, additional, Gunstone, Anthony, additional, Hall, Timothy, additional, Hanif, Wasim, additional, Jackson, Alan, additional, Johnson, Andrew, additional, Joseph, Franklin, additional, Krishnan, Singhan, additional, Kumwenda, Mick, additional, MacDougall, Iain, additional, Nixon, Paul, additional, O’Hare, Joseph, additional, Philip, Sam, additional, Ramtoola, Shenaz, additional, Saxena, Manish, additional, Sennik, Davesh, additional, Simon, Godwin, additional, Singh, Baldev, additional, Stephens, Jeffrey, additional, Strzelecka, Anna, additional, Symonds, Rehan, additional, Turner, Wayne, additional, Wahba, Mona, additional, Wakeling, John, additional, Wheeler, David, additional, Winocour, Peter, additional, Abdallah, Joseph, additional, Abdullah, Raied, additional, Abramowitz, Matthew, additional, Acosta, Idalia, additional, Aiello, Joseph, additional, Akright, Laura, additional, Akyea-Djamson, Ayim, additional, Alappan, Rajendran, additional, Alicic, Radica, additional, Al-Karadsheh, Amer, additional, Allison, Dale Crawford, additional, Arauz-Pacheco, Carlos, additional, Arfeen, Shahabul, additional, Arif, Ahmed, additional, Arvind, Moogali, additional, Atray, Naveen, additional, Awad, Ahmed, additional, Bakris, George, additional, Barnhill, Peggy, additional, Barranco, Elizabeth, additional, Barrera, Carlos, additional, Beacom, Matthew, additional, Behara, Venkata, additional, Belo, Diogo, additional, Bentley-Lewis, Rhonda, additional, Berenguer, Ramon, additional, Bermudez, Lidia, additional, Bernardo, Marializa, additional, Biscoveanu, Mihaela, additional, Bowman-Stroud, Cynthia, additional, Brandon, Donald, additional, Brusco, Osvaldo, additional, Busch, Robert, additional, Canaan, Yamil, additional, Chilito, Alicia, additional, Christensen, Tom, additional, Christiano, Cynthia, additional, Christofides, Elena, additional, Chuateco, Caroucel, additional, Cohen, Kenneth, additional, Cohen, Robert, additional, Cohen-Stein, Debbie, additional, Cook, Charles, additional, Coyne, Daniel, additional, Daboul, Nizar, additional, Darwish, Riad, additional, Daswani, Adarsh, additional, Deck, Kenneth, additional, Desouza, Cyrus, additional, Dev, Devasmita, additional, Dhillon, Monika, additional, Dua, Sohan, additional, Eder, Frank, additional, Elosegui, Ana Maria, additional, El-Shahawy, Mohamed, additional, Ervin, John, additional, Esquenazi, Alberto, additional, Evans, John, additional, Fishbane, Steven, additional, Frias, Juan, additional, Galindo-Ramos, Eugenia, additional, Galphin, Claude, additional, Ghazi, Adline, additional, Gonzalez, Enrique, additional, Gorson, David, additional, Gowda, Anupama, additional, Greco, Barbara, additional, Grubb, Stephen, additional, Gulati, Rakesh, additional, Hammoud, Jamal, additional, Handelsman, Stuart, additional, Hartman, Israel, additional, Hershon, Kenneth, additional, Hiser, Daniel, additional, Hon, George, additional, Jacob, Radu, additional, Jaime, Maria, additional, Jamal, Aamir, additional, Kaupke, Charles, additional, Keightley, Gerald, additional, Kern, Elizabeth, additional, Khanna, Rakhi, additional, Khitan, Zeid, additional, Kim, Sun, additional, Kopyt, Nelson, additional, Kovesdy, Csaba, additional, Krishna, Gopal, additional, Kropp, Jeffrey (Jay), additional, Kumar, Amrendra, additional, Kumar, Jayant, additional, Kumar, Neil, additional, Kusnir, Jorge, additional, Lane, Wendy, additional, Lawrence, Mary, additional, Lehrner, Lawrence, additional, Lentz, John, additional, Levinson, Dennis, additional, Lewis, Derek, additional, Liss, Kenneth, additional, Maddux, Andreas, additional, Maheshwari, Hiralal, additional, Mandayam, Sreedhar, additional, Marar, Isam, additional, Mehta, Bhasker, additional, Middleton, John, additional, Mordujovich, Jorge, additional, Moreda, Ramon, additional, Moustafa, Moustafa, additional, Mujica Trenche, Samuel, additional, Narayanan, Mohanram, additional, Narvarte, Javier, additional, Nassar, Tareq, additional, Newman, George, additional, Nichol, Brian, additional, Nicol, Philip, additional, Nisnisan, Josier, additional, Nossuli, A. Kaldun, additional, Obialo, Chamberlain, additional, Olelewe, Sarah, additional, Oliver, Michael, additional, O’Shaughnessy, Andrew, additional, Padron, John, additional, Pankhaniya, Rohit, additional, Parker, Reginald, additional, Patel, Devesh, additional, Patel, Gnyandev, additional, Patel, Nina, additional, Pavon, Humberto, additional, Perez, Armando, additional, Perez, Carlos, additional, Perlman, Alan, additional, Pettis, Karlton, additional, Pharr, Walter, additional, Phillips, Andrea, additional, Purighalla, Raman, additional, Quesada-Suarez, Luis, additional, Ranjan, Rajiv, additional, Rastogi, Sanjeev, additional, Reddy, Jakkidi, additional, Rendell, Marc, additional, Rich, Lisa, additional, Robinson, Michael, additional, Rodriguez, Hector, additional, Rosas, Sylvia, additional, Saba, Fadi, additional, Sankaram, Rallabhandi, additional, Sarin, Ravi, additional, Schreiman, Robert, additional, Scott, David, additional, Sekkarie, Mohamed, additional, Sensenbrenner, John, additional, Shakeel, Muhammad, additional, Shanik, Michael, additional, Shaw, Sylvia, additional, Smith, Stephen, additional, Solomon, Richard, additional, Sprague, Amy, additional, Spry, Leslie, additional, Suchinda, Pusadee, additional, Sultan, Senan, additional, Surampudi, Prasanth, additional, Sussman, Sherry, additional, Tan, Anjanette, additional, Terrelonge, Antonio, additional, Thompson, Michael, additional, Trespalacios, Fernando, additional, Trippe, Bruce, additional, Trueba, Pilar, additional, Twahirwa, Marcel, additional, Updegrove, John, additional, Van Buren, Peter, additional, Vannorsdall, Mark, additional, Varghese, Freemu, additional, Velasquez-Mieyer, Pedro, additional, Ventrapragada, Sailaja, additional, Vukotic, Goga, additional, Wadud, Khurram, additional, Warren, Mark, additional, Watson, Henry, additional, Watts, Ronald, additional, Weiner, Daniel, additional, Welker, James, additional, Welsh, Jean, additional, Williams, Shelley, additional, and Zaniewski-Singh, Michelle, additional

Published
2021
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38. Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up

Author

Santos-García, Diego, Deus, Teresa de, Cores, Carlos, Canfield, Hector, González, Jose Paz, Miró, Cristina Martínez, Aymerich, Lorena Valdés, Suárez, Ester, Jesús, Silvia, Aguilar, Miquel, Pastor, Pau, Planellas, Lluis, Cosgaya, Marina, Caldentey, Juan García, Caballol, Nuria, Legarda, Ines, Hernández-Vara, Jorge, Cabo, Iria, Manzanares, Lydia López, Aramburu, Isabel González, Rivera, Maria Ávila, Catalán, Maria, Nogueira, Victor, Puente, Victor, Dotor, Julio, Borrué, Carmen, Solano, Berta, Sauco, Maria Álvarez, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo, Francisco, Castrillo, Juan Martínez, Alonso, Pilar Sánchez, Alonso, Gemma, Ariztegui, Nuria López, Gastón, Itziar, Kulisevsky, Jaime, Blázquez, Marta, Seijo, Manuel, Martínez, Javier Rúiz, Valero, Caridad, Kurtis, Monica, Fábregues, Oriol de, Ardura, Jessica, Alonso, Ruben, Ordás, Carlos, Díaz, Luis López, McAfee, Darrian, Martinez-Martin, Pablo, Mir, Pablo, Group, COPPADIS Study, Curemos el Párkinson, Institut Català de la Salut, [Santos García D, Cores C, Paz González JM, Martínez Miró C] CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus T, Canfield H] CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández-Vara J, de Fábregues O] Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Quality of life, 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, mood, Otros calificadores::/diagnóstico [Otros calificadores], Medicine (miscellaneous), Non-motor symptoms, Disease, Símptomes, Article, Parkinson, Malaltia de - Diagnòstic, 03 medical and health sciences, Pathological Conditions, Signs and Symptoms::Signs and Symptoms [DISEASES], 0302 clinical medicine, enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson [ENFERMEDADES], Malaltia de Parkinson, Internal medicine, Mood, Linear regression, Other subheadings::/diagnosis [Other subheadings], medicine, afecciones patológicas, signos y síntomas::signos y síntomas [ENFERMEDADES], ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD], Progression, business.industry, Neuropsychiatric inventory, medicine.disease, non-motor symptoms, Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE], 030104 developmental biology, quality of life, Qualitat de vida, Cohort, Parkinson’s disease, Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease [DISEASES], Medicine, Non motor, progression, business, 030217 neurology & neurosurgery
Abstract

Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28, p &lt, 0.0001, N = 501, 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82, p = 0.428, N = 122, 49.5% males, mean age 60.99 ± 8.32) (p &lt, 0.0001). NMSS total score at baseline (β = −0.52), change from V0 to V2 in PDSS (Parkinson’s Disease Sleep Scale) (β = −0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41, Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.

Published
2021

39. Expression of the insecticidal bean alpha-amylase inhibitor transgene has minimal detrimental effect on the nutritional value of peas fed to rats at 30% of the diet

Author

Pusztai, A., Bardocz, G. Grant S., Alonso, Ruben, Chrispeels, M.J., Schroeder, H.E., Tabe, L.M., and Higgins, T.J.V.

Subjects
Amylases -- Inhibitors, Genetically modified plants -- Health aspects, Peas -- Health aspects, Rats -- Food and nutrition, Insecticidal plants -- Health aspects, Food/cooking/nutrition
Abstract

The effect of expression of bean [Alpha]-amylase inhibitor ([Alpha]-Al) transgene on the nutritional value of peas has been evaluated by pair-feeding rats diets containing transgenic or parent peas at 300 and 650 g/kg, respectively, and at 150 g protein/kg diet, supplemented with essential amino acids to target requirements. The results were also compared with the effects of diets containing lactalbumin with or without 0.9 or 2.0 mg bean [Alpha]-Al, levels equivalent to those in transgenic pea diets. When 300 and 650 g peas/kg diet were fed, the daily intake of [Alpha]-Al was 11.5 or 26.3 mg [Alpha]-Al, respectively. At the 300 g/kg level, the nutritional value of the transgenic and parent line peas was not significantly different. The weight gain and tissue weights of rats fed either of the two pea diets were not significantly different from each other or from those of rats given the lactalbumin diet even when this was supplemented with 0.9 g [Alpha]-Al/kg. The digestibilities of protein and dry matter of the pea diets were slightly but significantly lower than those of the lactalbumin diet, probably due to the presence of naturally occurring antinutrients in peas. The nutritional value of diets containing peas at the higher (650 g) inclusion level was less than that of the lactalbumin diet. However, the differences between transgenic and parent pea lines were small, possibly because neither the purified recombinant [Alpha]-Al nor that in transgenic peas inhibited starch digestion in the rat small intestine in vivo to the same extent as did bean [Alpha]-Al. This was the case even though both forms of [Alpha]-Al equally inhibited [Alpha]-amylase in vitro. Thus, this short-term study indicated that transgenic peas expressing bean [Alpha]-Al gene could be used in rat diets at 300 g/kg level without major harmful effects on their growth, metabolism and health, raising the possibility that transgenic peas may also be used at this level in the diet of farm animals. KEY WORDS: transgenic peas; [Alpha]-amylase inhibitor; nutritional value; growth; rats

Published
1999

40. Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups

Author

Mahaffey, Kw, Jardine, Mj, Bompoint, S, Cannon, Cp, Neal, B, Heerspink, Hjl, Charytan, Dm, Edwards, R, Agarwal, R, Bakris, G, Bull, S, Capuano, G, de Zeeuw, D, Greene, T, Levin, A, Pollock, C, Sun, T, Wheeler, Dc, Yavin, Y, Zhang, H, Zinman, B, Rosenthal, N, Brenner, Bm, Perkovic, V, Guerrero, Raa, Aizenberg, D, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Colaso, Pdg, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, de la Fuente, Ral, Marchetta, N, Mele, P, Nicolai, S., Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Papini, Nr, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Casabella, Ts, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, da Costa, Faa, Amodeo, C, Turatti, Laa, Bregman, R, Sanches, Fcc, Canani, Lh, Chacra, Ar, Cunha Borges, Jl, Vencio, Sac, Franco, Rjd, D'Avila, D, Portes, Ed, de Souza, P, Deboni, Lm, Fraige, F, Neto, Bg, Gomes, M, Kohara, Sk, Keitel, E, Saraiva, Jfk, Lisboa, Hrk, Contieri, Fld, Milagres, R, Montenegro, R, de Brito, Cm, Hissa, Mn, Sabbag, Arn, Noronha, I, Panarotto, D, Pecoits, R, Pereira, Ma, Saporito, W, Scotton, As, Schuch, T, de Almeida, Rs, Ramos, Cs, Felicio, Js, Thome, F, Hachmann, Jct, Yamada, S, Hayashida, Cy, Petry, Tbz, Zanella, Mt, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A., Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Cherney, D, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dube, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mcmahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, Nadia, Fernandez Montenegro, Maria Alicia, Godoy Jorquera, Juan Gonzalo, Medina Farina, Marcelo, Saavedra Gajardo, Victor, Vejar, Margarita, Chen, Nan, Chen, Qinkai, Gan, Shenglian, Kong, Yaozhong, Detian, Li, Wenge, Li, Xuemei, Li, Lin, Hongli, Liu, Jian, Weiping, Lu, Mao, Hong, Ren, Yan, Song, Weihong, Sun, Jiao, Sun, Lin, Ping, Tu, Wang, Guixia, Yang, Jinkui, Yin, Aiping, Xueqing, Yu, Zhao, Minghui, Zheng, Hongguang, Accini Mendoza, Jose Luis, Arcos, Edgar, Avendano, Jorge, Diaz Ruiz, Jorge Ernesto Andres, Garcia Ortiz, Luis Hernando, Gonzalez, Alexander, Hernandez Triana, Eric, Diego Higuera, Juan, Malaver, Natalia, Ines Molina de Salazar, Dora, Rosero, Ricardo, Terront Lozano, Monica Alexandra, Valderrama Cometa, Luis, Valenzuela, Alex, Vargas Alonso, Ruben Dario, Villegas, Ivan, Yupanqui, Hernan, Bartaskova, Dagmar, Barton, Petr, Belobradkova, Jana, Dohnalova, Lenka, Drasnar, Tomas, Ferkl, Richard, Halciakova, Katarina, Klokocnikova, Vera, Kovar, Richard, Lastuvka, Jiri, Lukac, Martin, Pesickova, Satu, Peterka, Karel, Pumprla, Jiri, Rychlik, Ivan, Saudek, Frantisek, Tesar, Vladimir, Valis, Martin, Weiner, Pavel, Zemek, Stanislav, Alamartine, Eric, Borot, Sophie, Cariou, Bertrand, Dussol, Bertrand, Fauvel, Jean-Pierre, Gourdy, Pierre, Klein, Alexandre, Le Meur, Yannick, Penfornis, Alfred, Roussel, Ronan, Saulnier, Pierre-Jean, Thervet, Eric, Zaoui, Philippe, Burst, Volker, Faghih, Markus, Faulmann, Grit, Haller, Hermann, Jerwan-Keim, Reinhold, Maxeiner, Stephan, Paschen, Bjoern, Plassmann, Georg, Rose, Ludger, Gonzalez Orellana, Ronaldo Arturo, Paul Haase, Franklin, Moreira Diaz, Juan Pablo, Ramirez Roca, Luis Alberto, Sanchez Arenales, Jose Antonio, Sanchez Polo, Jose Vicente, Turcios Juarez, Erick, Csecsei, Gyongyi, Csiky, Botond, Danos, Peter, Deak, Laszlo, Dudas, Mihaly, Harcsa, Eleonora, Keltai, Katalin, Keresztesi, Sandor, Kiss, Konyves, Laszlo, Major, Lajos, Mileder, Margit, Molnar, Marta, Mucsi, Janos, Oroszlan, Tamas, Ory, Ivan, Paragh, Gyorgy, Peterfai, Eva, Petro, Gizella, Revesz, Katalin, Takacs, Robert, Vangel, Sandor, Vasas, Szilard, Zsom, Marianna, Abraham, Oomman, Bhushan, Raju Sree, Deepak, Dewan, Edwin, Fernando M., Gopalakrishnan, Natarajan, Gracious, Noble, Hansraj, Alva, Jain, Dinesh, Keshavamurthy, C. B., Khullar, Dinesh, Manisha, Sahay, Peringat, Jayameena, Prasad, Narayan, Satyanarayana, Rao K., Sreedhar, Reddy, Sreelatha, Melemadathil, Sudhakar, Bhimavarapu, Vyasam, Ramesh Chandra, Bonadonna, Riccardo, Castellino, Pietro, Ceriello, Antonio, Chiovato, Luca, De Cosmo, Salvatore, De Nicola, Luca, Derosa, Giuseppe, Di Carlo, Alberto, Di Cianni, Graziano, Frasca, Giovanni, Fuiano, Giorgio, Gambaro, Giovanni, Garibotto, Giacomo, Giorda, Carlo, Malberti, Fabio, Mandreoli, Marcora, Mannucci, Edoardo, Orsi, Emanuela, Piatti, Piermarco, Santoro, Domenico, Sasso, Ferdinando Carlo, Serviddio, Gaetano, Stella, Andrea, Trevisan, Roberto, Veronelli, Anna Maria, Zanoli, Luca, Akiyama, Hitoshi, Aoki, Hiromi, Asano, Akimichi, Iitsuka, Tadashi, Kajiyama, Shizuo, Kashine, Susumu, Kawada, Toshio, Kodera, Takamoto, Kono, Hiroshi, Koyama, Kazunori, Kumeda, Yasuro, Miyauchi, Shozo, Mizuyama, Kazuyuki, Niiya, Tetsuji, Oishi, Hiroko, Ota, Satoshi, Sakakibara, Terue, Takai, Masahiko, Tomonaga, Osamu, Tsujimoto, Mitsuru, Wada, Takashi, Wakasugi, Masakiyo, Wakida, Yasushi, Watanabe, Takayuki, Yamada, Masayo, Yanagida, Kazuhiro, Yanase, Toshihiko, and Yumita, Wataru

Subjects
Male, Risk, primary prevention, canagliflozin, clinical trial, diabetes mellitus, renal insufficiency, chronic, secondary prevention, renal insufficiency, Double-Blind Method, Original Research Articles, Humans, Sodium-Glucose Transporter 2 Inhibitors, Proportional Hazards Models, canagliflozin, clinical trial, diabetes mellitus, primary prevention, renal insufficiency, chronic, secondary prevention, Middle Aged, Placebo Effect, chronic, Treatment Outcome, Diabetes Mellitus, Type 2, Cardiovascular Diseases, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Kidney Failure, Chronic, Female
Abstract

Supplemental Digital Content is available in the text., Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67–0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49–0.94]) and secondary (HR, 0.85 [95% CI, 0.69–1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61–1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59–1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56–1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02065791.

Published
2019

47. Cálculo sísmico de estructuras convencionales de edificación aplicando métodos lineales y no lineales implementados en diferentes normas. Estudio comparativo

Author

Alonso Alonso, Ruben and Benavent Climent, Amadeo

Subjects
Ingeniería Civil y de la Construcción
Abstract

El objetivo de este trabajo bajo el título “Cálculo sísmico de estructuras convencionales de edificación aplicando métodos lineales y no lineales implementados en diferentes normas. Estudio comparativo” es, en primer lugar, evaluar las diferencias entre los principales métodos de cálculo lineales y no lineales para proyectar estructuras porticadas convencionales de hormigón armado. Los métodos de cálculo desarrollados son los siguientes cuatro: 1) Cálculos estáticos lineales mediante la implementación de los métodos simplificados de la NCSE-02 y del EN1998-1 (Eurocódigo 8). 2) Cálculos dinámicos lineales (análisis modal espectral) según EN 1998-1. 3) Cálculos estáticos no lineales (Capacity Spectrum Method) según la FEMA 440. 4) Cálculos dinámicos directos no lineales con acelerogramas reales escalados según el EN 1998-1. Como resultado de la comparativa de dichos métodos, se constata la importancia de los «métodos de cálculo estáticos no lineales» suponiendo un avance para el proyecto de estructuras sismorresistentes respecto a los métodos tradicionales basados en fuerzas. En este sentido, como método de cálculo estático no lineal, se incluye el «Capacity Spectrum Method» presentado en la ATC 40 (1996) y posteriormente mejorado en la FEMA 440. Mediante su aplicación, se ponen de manifiesto ventajas del método entre las que destaca la posibilidad de cuantificar el nivel de daño de la estructura permitiendo, además, la posibilidad de materializar el nuevo paradigma que surge en la década de los 90 del siglo pasado llamado «Proyecto sismorresistente basado en prestaciones», por el cual, se pueden concebir y proyectar estructuras que sean capaces de exhibir un nivel de daño predecible cuando son afectadas por los terremotos. Asimismo, en el presente trabajo, se cuantifica la reducción, en cuanto a medición total de kilos de acero pasivo, que puede implicar la aplicación de los métodos de cálculo estáticos no lineales frente a los métodos tradicionales basados en fuerzas (análisis modal espectral). Por otro lado, mediante cálculos estáticos lineales, se realiza una comparativa entre la normativa española NCSE-02 y el EN 1998-1. Como resultado de dicha comparativa se ponen de manifiesto las diferencias entre ambas normas a la hora de definir los requisitos asociados al mecanismo de colapso del tipo “viga débil-columna fuerte” y la importancia de dicho mecanismo en el Proyecto Sismorresistente de Estructuras. Se cuantifican dichas diferencias desde el punto de vista técnico, e incluso económico, valorando la repercusión en la medición total de kilos de acero pasivo y volumen (m3) de hormigón. El trabajo está estructurado en los siguientes 6 capítulos: El capítulo 1 introduce el objetivo y la metodología aplicada. El capítulo 2 describe el estado del conocimiento de las diferentes metodologías de cálculo existentes, así como las soluciones estructurales convencionales y avanzadas en el proyecto sismorresistente. Igualmente se detalla el concepto de ductilidad y sus diferentes tipos. El capítulo 3 define el prototipo estructural utilizado, así como cargas, materiales, bases de cálculo y niveles de ductilidad aplicados en las distintas simulaciones numéricas realizadas. En el capítulo 4 y 5 se desarrollan todos los cálculos realizados bajo los diferentes métodos de cálculo. Se obtienen resultados numéricos, principalmente desplazamientos, cortantes basales y aceleraciones absolutas por niveles para una posterior comparación e interpretación. Finalmente, en el capítulo 6, se incluye una comparativa de la predicción obtenida de desplazamientos, aceleraciones absolutas y cortantes basales mediante los diferentes métodos de cálculos empleados. Se presentan por ultimo las conclusiones y las futuras líneas de investigación propuestas.

Published
2016

48. La prostitució com a arma de violència contra els treballadors del sexe

Author

García Alonso, Ruben, Universitat Oberta de Catalunya, and Guardiola Lago, Maria Jesús

Subjects
abolicionisme, prostituciò, treballadors del sexe, prohibicionisme, prostitución, prohibicionismo, trabajadores sexuales, Prostitución -- Derecho y legislación -- TFG, prostitution, criminología, Prostitució -- Dret i legislació -- TFG, criminologia, Prostitution -- Law and legislation -- TFG, abolicionismo, prohibitionism, criminology, abolitionism, sex workers
Abstract

Aquest és un treball de recerca documental sobre els models político-criminals i legals que podem trobar en l'àmbit de la prostitució a diferents països. En aquest sentit, s'analitzaran els models reglamentaristes, abolicionistes, prohibicionistes i regulacionistes, prenent en consideració alguns països que es podrien situar en cadascuna de les tendències apuntades. A partir de l'estudi de diferents legislacions nacionals i internacionals, es tractarà de donar respostes de suport o que refutin la hipòtesi de partida d'aquest treball, la qual parteix del fet que tots els models político-criminals existents en l'actualitat produeixen una victimització cap als treballadors del sexe. This document is a documentary research on politico-criminal and legal models that can be found in the prostitution field in different countries. In this sense, partial decriminalisation, abolitionism, prohibitionism and legalisationism models will be analysed, taking into consideration some countries that could be located in each of the named trends. From the study of different national and international laws, it will seek to provide answers to support or reject the hypothesis of this work, which assumes that all currently existing politico-criminal models produce victimization to workers sex. Este es un trabajo de búsqueda documental sobre los modelos político-criminales y legales que podemos encontrar en el ámbito de la prostitución en diferentes países. En este sentido, se analizaran los modelos reglamentistas, abolicionistas, prohibicionistas y regulacionistas, teniendo en consideración algunos países que se podrían situar en cada una de les tendencias apuntadas. A partir del estudio de diferentes legislaciones nacionales e internacionales, se tratará de dar respuestas que refuercen o que rechacen la hipótesis de partida de este trabajo, la cual parte de que todos los modelos político-criminales existentes en la actualidad producen una victimización hacia los trabajadores del sexo.

Published
2016

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