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Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
- Source :
- Journal of Personalized Medicine, Volume 11, Issue 7, Digital.CSIC. Repositorio Institucional del CSIC, instname, Journal of Personalized Medicine, Vol 11, Iss 626, p 626 (2021), Scientia, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28<br />p &lt<br />0.0001<br />N = 501<br />60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82<br />p = 0.428<br />N = 122<br />49.5% males, mean age 60.99 ± 8.32) (p &lt<br />0.0001). NMSS total score at baseline (β = −0.52), change from V0 to V2 in PDSS (Parkinson’s Disease Sleep Scale) (β = −0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41<br />Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.
- Subjects :
- Quality of life
0301 basic medicine
medicine.medical_specialty
Parkinson's disease
mood
Otros calificadores::/diagnóstico [Otros calificadores]
Medicine (miscellaneous)
Non-motor symptoms
Disease
Símptomes
Article
Parkinson, Malaltia de - Diagnòstic
03 medical and health sciences
Pathological Conditions, Signs and Symptoms::Signs and Symptoms [DISEASES]
0302 clinical medicine
enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson [ENFERMEDADES]
Malaltia de Parkinson
Internal medicine
Mood
Linear regression
Other subheadings::/diagnosis [Other subheadings]
medicine
afecciones patológicas, signos y síntomas::signos y síntomas [ENFERMEDADES]
ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD]
Progression
business.industry
Neuropsychiatric inventory
medicine.disease
non-motor symptoms
Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE]
030104 developmental biology
quality of life
Qualitat de vida
Cohort
Parkinson’s disease
Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease [DISEASES]
Medicine
Non motor
progression
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20754426
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Personalized Medicine
- Accession number :
- edsair.doi.dedup.....21d1e7001113eea1eb4d9e9bcc34c193