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5. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. I. Taxonomy, fermentation and biological activity.

Author

Bernan VS, Montenegro DA, Goodman JJ, Alluri MR, Carter GT, Abbanat DR, Pearce CJ, Maiese WM, and Greenstein M

Subjects
Animals, Anti-Bacterial Agents pharmacology, Artemia drug effects, Ethers pharmacology, Fermentation, Gram-Positive Bacteria drug effects, Insecticides pharmacology, Microscopy, Electron, Scanning, Molecular Structure, Spodoptera, Streptomyces classification, Streptomyces ultrastructure, Anti-Bacterial Agents biosynthesis, Streptomyces metabolism
Abstract

Actinomycete culture LL-D37187 has been found to produce the new polyether antibiotic martinomycin. Taxonomic studies, including morphological, physiological, and cell wall chemistry analyses, revealed that culture LL-D37187 is a novel streptomycete species, and the proposed name is Streptomyces salvialis. Martinomycin exhibits activity against the Southern Army Worm (Spodoptera eridania) and Gram-positive bacteria.

Published
1994
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6. Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. II. Isolation and structure determination.

Author

Carter GT, Schlingmann G, Kenion GB, Milne L, Alluri MR, Korshalla JD, Williams DR, Pinho F, and Borders DB

Subjects
Anti-Bacterial Agents biosynthesis, Anti-Bacterial Agents chemistry, Ethers chemistry, Ethers isolation & purification, Insecticides chemistry, Insecticides isolation & purification, Insecticides metabolism, Magnetic Resonance Spectroscopy, Molecular Structure, Anti-Bacterial Agents isolation & purification, Streptomyces metabolism
Published
1994
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7. Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

Author

Ding W, Williams DR, Northcote P, Siegel MM, Tsao R, Ashcroft J, Morton GO, Alluri M, Abbanat D, and Maiese WM

Subjects
Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Macrolides, Streptomyces metabolism
Abstract

Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.

Published
1994
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