Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

Authors :: Ding W
Williams DR
Northcote P
Siegel MM
Tsao R
Ashcroft J
Morton GO
Alluri M
Abbanat D
Maiese WM
Source :: The Journal of antibiotics [J Antibiot (Tokyo)] 1994 Nov; Vol. 47 (11), pp. 1250-7.
Publication Year :: 1994
Abstract: Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.

Subjects :: Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Macrolides
Streptomyces metabolism

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