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1. Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

Author

Alice E. Law, Rebecca K. Shears, Andrea A. Lopez Rodas, Richard K. Grencis, Philip J. Cooper, Daniel R. Neill, and Aras Kadioglu

Subjects
Medicine, Science
Abstract

Abstract Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.

Published
2021
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2. Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease

Author

Philip J. Cooper, Andrea A. Lopez Rodas, Richard K. Grencis, Rebecca K. Shears, Daniel R. Neill, Alice E. Law, and Aras Kadioglu

Subjects
Male, 0301 basic medicine, Pneumococcal carriage, Burden of disease, Science, 030231 tropical medicine, Helminthiasis, Microbiology, Article, Pneumococcal Infections, Mice, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, parasitic diseases, Animals, Humans, Helminths, Medicine, Intestinal Diseases, Parasitic, Risk factor, Clinical microbiology, Child, Cause of death, Multidisciplinary, Bacteria, Coinfection, Invasive disease, business.industry, 3. Good health, Streptococcus pneumoniae, 030104 developmental biology, Carriage, Child, Preschool, Immunology, Infectious diseases, Parasitology, Female, Ecuador, Infection, business, Co infection
Abstract

Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.

Published
2021

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