Back to Search
Start Over
Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease
- Source :
- SCIENTIFIC REPORTS, Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated with increased pneumococcal carriage density and dissemination into lungs. Helminth-infected children also exhibited increased carriage density as compared to uninfected children. Anthelmintic treatment may be a cost-effective method of reducing pneumococcal disease burden in lower-income countries.
- Subjects :
- Male
0301 basic medicine
Pneumococcal carriage
Burden of disease
Science
030231 tropical medicine
Helminthiasis
Microbiology
Article
Pneumococcal Infections
Mice
03 medical and health sciences
0302 clinical medicine
Risk Factors
parasitic diseases
Animals
Humans
Helminths
Medicine
Intestinal Diseases, Parasitic
Risk factor
Clinical microbiology
Child
Cause of death
Multidisciplinary
Bacteria
Coinfection
Invasive disease
business.industry
3. Good health
Streptococcus pneumoniae
030104 developmental biology
Carriage
Child, Preschool
Immunology
Infectious diseases
Parasitology
Female
Ecuador
Infection
business
Co infection
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....00695fbf960db56412ace5b491728105