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1. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Ashraful, Nahar Begum, SM Khodeza, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, Yilmaz, Omer H, Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, and Syed, Sana

Published
2024
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2. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J, Marie, Chelsea, Mazumder, Ramendra Nath, Mudenda, Victor, Mulenga, Chola, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, VanBuskirk, Kelley, Mweetwa, Monica, Kolterman, Tad, Raghavan, Shyam, Ahmed, Tahmeed, Ali, S Asad, Nahar Begum, SM Khodeza, Besa, Ellen, Denno, Donna M, Jamil, Zehra, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Mouksassi, Samer, Petri, William A, Jr., Tarr, Phillip I, Sullivan, Peter B, and Moskaluk, Christopher A

Published
2024
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3. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, and Denno, Donna M

Published
2024
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4. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Zyambo, Kanekwa, Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, and Denno, Donna M

Published
2024
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5. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Zyambo, Kanekwa, Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Jr, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Ömer H Yilmaz, Raghavan, Shyam S, Moskaluk, Christopher A, and Liu, Ta-Chiang

Published
2024
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6. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa, Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Jr., Tarr, Phillip I, and Denson, Lee A

Published
2024
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7. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Jr., and Ali, S Asad

Published
2024
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8. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Jr, Sullivan, Peter B, and Tarr, Phillip I

Published
2024
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9. Self-Attentive Adversarial Stain Normalization

Author

Shrivastava, Aman, Adorno, Will, Sharma, Yash, Ehsan, Lubaina, Ali, S. Asad, Moore, Sean R., Amadi, Beatrice C., Kelly, Paul, Syed, Sana, and Brown, Donald E.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Quantitative Biology - Quantitative Methods
Abstract

Hematoxylin and Eosin (H&E) stained Whole Slide Images (WSIs) are utilized for biopsy visualization-based diagnostic and prognostic assessment of diseases. Variation in the H&E staining process across different lab sites can lead to significant variations in biopsy image appearance. These variations introduce an undesirable bias when the slides are examined by pathologists or used for training deep learning models. To reduce this bias, slides need to be translated to a common domain of stain appearance before analysis. We propose a Self-Attentive Adversarial Stain Normalization (SAASN) approach for the normalization of multiple stain appearances to a common domain. This unsupervised generative adversarial approach includes self-attention mechanism for synthesizing images with finer detail while preserving the structural consistency of the biopsy features during translation. SAASN demonstrates consistent and superior performance compared to other popular stain normalization techniques on H&E stained duodenal biopsy image data., Comment: Accepted at AIDP (ICPR 2021)

Published
2019

10. Diagnosis of Celiac Disease and Environmental Enteropathy on Biopsy Images Using Color Balancing on Convolutional Neural Networks

Author

Kowsari, Kamran, Sali, Rasoul, Khan, Marium N., Adorno, William, Ali, S. Asad, Moore, Sean R., Amadi, Beatrice C., Kelly, Paul, Syed, Sana, and Brown, Donald E.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods, Statistics - Machine Learning
Abstract

Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. CD is an autoimmune disorder that is prevalent worldwide and is caused by an increased sensitivity to gluten. Gluten exposure destructs the small intestinal epithelial barrier, resulting in nutrient mal-absorption and childhood under-nutrition. EE also results in barrier dysfunction but is thought to be caused by an increased vulnerability to infections. EE has been implicated as the predominant cause of under-nutrition, oral vaccine failure, and impaired cognitive development in low-and-middle-income countries. Both conditions require a tissue biopsy for diagnosis, and a major challenge of interpreting clinical biopsy images to differentiate between these gastrointestinal diseases is striking histopathologic overlap between them. In the current study, we propose a convolutional neural network (CNN) to classify duodenal biopsy images from subjects with CD, EE, and healthy controls. We evaluated the performance of our proposed model using a large cohort containing 1000 biopsy images. Our evaluations show that the proposed model achieves an area under ROC of 0.99, 1.00, and 0.97 for CD, EE, and healthy controls, respectively. These results demonstrate the discriminative power of the proposed model in duodenal biopsies classification.

Published
2019

13. Self-attentive Adversarial Stain Normalization

Author

Shrivastava, Aman, Adorno, William, Sharma, Yash, Ehsan, Lubaina, Ali, S. Asad, Moore, Sean R., Amadi, Beatrice, Kelly, Paul, Syed, Sana, Brown, Donald E., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Del Bimbo, Alberto, editor, Cucchiara, Rita, editor, Sclaroff, Stan, editor, Farinella, Giovanni Maria, editor, Mei, Tao, editor, Bertini, Marco, editor, Escalante, Hugo Jair, editor, and Vezzani, Roberto, editor

Published
2021
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14. Diagnosis of Celiac Disease and Environmental Enteropathy on Biopsy Images Using Color Balancing on Convolutional Neural Networks

Author

Kowsari, Kamran, Sali, Rasoul, Khan, Marium N., Adorno, William, Ali, S. Asad, Moore, Sean R., Amadi, Beatrice C., Kelly, Paul, Syed, Sana, Brown, Donald E., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Arai, Kohei, editor, Bhatia, Rahul, editor, and Kapoor, Supriya, editor

Published
2020
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15. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multi-country analysis

Author

Ehsan, Lubaina, primary, Coomes, David, additional, Kelly, Paul, additional, Greene, Adam R., additional, Ali, S. Asad, additional, Mulenga, Chola, additional, Denno, Donna M., additional, VanBuskirk, Kelley, additional, Raghib, Muhammad Faraz, additional, Mahfuz, Mustafa, additional, Moore, Sean R., additional, Hossain, M. Shabab, additional, Ahmed, Tahmeed, additional, Sullivan, Peter B., additional, Moskaluk, Christopher A., additional, Syed, Sana, additional, Ahmed, Kumail, additional, Ahmed, Sheraz, additional, Alam, Md. Ashraful, additional, Begum, S.M. Khodeza Nahar, additional, Das, Subhasish, additional, Denson, Lee A., additional, Fahim, Shah Mohammad, additional, Gazi, Md. Amran, additional, Hasan, Md. Mehedi, additional, Hotwani, Aneeta, additional, Iqbal, Junaid, additional, Jamil, Zehra, additional, Kabir, Furqan, additional, Liu, Ta-Chiang, additional, Mazumder, Ramendra Nath, additional, Ragahavan, Shyam S., additional, Rahman, Masudur, additional, Rahman, Najeeb, additional, Sadiq, Kamran, additional, Sarker, Shafiqul Alam, additional, Tarr, Phillip I., additional, Tearney, Guillermo J., additional, Umrani, Fayaz, additional, Umutesi, Grace, additional, and Yilmaz, Omer H., additional

Published
2024
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16. Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

Author

VanBuskirk, Kelley, Mweetwa, Monica, Kolterman, Tad, Raghavan, Shyam, Ahmed, Tahmeed, Ali, S Asad, Nahar Begum, SM Khodeza, Besa, Ellen, Denno, Donna M, Jamil, Zehra, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Mouksassi, Samer, Petri, William A, Tarr, Phillip I, Sullivan, Peter B, Moskaluk, Christopher A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J, Marie, Chelsea, Mazumder, Ramendra Nath, Mudenda, Victor, Mulenga, Chola, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Tearney, Guillermo J, Umrani, Fayaz, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED) is characterized by reduced absorptive capacity and barrier function of the small intestine, leading to poor ponderal and linear childhood growth.

Published
2024
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17. Enteric pathogens relationship with small bowel histologic features of environmental enteric dysfunction in a multicountry cohort study

Author

Iqbal, Najeeha T, Lawrence, Sarah, Ahmed, Tahmeed, Chandwe, Kanta, Fahim, Shah M, Houpt, Eric R, Kabir, Furqan, Kelly, Paul, Liu, Jie, Mahfuz, Mustafa, Mweetwa, Monica, VanBuskirk, Kelley, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Ali, S. Asad, Amadi, Beatrice, Das, Subhasish, Gazi, Md. Amran, Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Raghavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental Enteric Dysfunction (EED) is an acquired disorder of asymptomatic altered gut function, the etiology of which is unknown. EED is postulated to be a major contributor to growth faltering in early childhood in regions where early-life enteropathogenic carriage is prevalent. Few studies have examined the critical organ (the upper small bowel) with enteropathogens in the evolution of small bowel disease.

Published
2024
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18. Biomarker relationships with small bowel histopathology among malnourished children with environmental enteric dysfunction in a multicountry cohort study

Author

Mahfuz, Mustafa, Coomes, David, Abdalla, Marwa, Mweetwa, Monica, VanBuskirk, Kelley, Iqbal, Najeeha T, Ali, S Asad, Chandwe, Kanta, Das, Subhasish, Kelly, Paul, Shaikh, Nurmohammad, Tarr, Phillip I, Denno, Donna M, Ahmed, Kumail, Ahmed, Sheraz, Ahmed, Tahmeed, Alam, Md. Ashraful, Amadi, Beatrice, Begum, S.M. Khodeza Nahar, Besa, Ellen, Fahim, Shah Mohammad, Gazi, Md. Amran, Gilchrist, Carol A., Haque, Rashidul, Hasan, Md. Mehedi, Hossain, Md. Shabab, Hotwani, Aneeta, Hussain, Shahneel, Iqbal, Junaid, Jakhro, Sadaf, Kabir, Furqan, Liu, Ta-Chiang, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B, Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H., and Zyambo, Kanekwa

Abstract

Validated biomarkers could catalyze environmental enteric dysfunction (EED) research.

Published
2024
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19. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children

Author

Kelly, Paul, VanBuskirk, Kelley, Coomes, David, Mouksassi, Samer, Smith, Gerald, Jamil, Zehra, Hossain, Md Shabab, Syed, Sana, Marie, Chelsea, Tarr, Phillip I, Sullivan, Peter B, Petri, William A, Denno, Donna M, Ahmed, Tahmeed, Mahfuz, Mustafa, Ali, S Asad, Moore, Sean R, Ndao, I Malick, Tearney, Guillermo J, Yilmaz, Ömer H, Raghavan, Shyam S, Moskaluk, Christopher A, Liu, Ta-Chiang, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Begum, S.M. Khodeza Nahar, Besa, Ellen, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A., Fahim, Shah Mohammad, Gazi, Md. Amran, Hasan, Md. Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Lawrence, Sarah, Mann, Barbara J., Mazumder, Ramendra Nath, Memon, Waheeda, Morgan, Brooks, Mudenda, Victor, Mulenga, Chola, Mweetwa, Monica, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Umrani, Fayaz, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic intestinal disorder associated with growth impairment, delayed neurocognitive development, and impaired oral vaccine responses.

Published
2024
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20. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Author

Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Tarr, Phillip I, Denson, Lee A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, and Zyambo, Kanekwa

Abstract

Environmental enteric dysfunction (EED) is an inflammatory condition of the small intestine that is prevalent in children residing in low- and middle-income countries. EED is accompanied by profound histopathologic changes in the small bowel, loss of absorptive capacity, increased intestinal permeability, increased microbial translocation, and nutrient loss.

Published
2024
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21. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction

Author

Denno, Donna M, Ahmed, Sheraz, Ahmed, Tahmeed, Ali, S Asad, Amadi, Beatrice, Kelly, Paul, Lawrence, Sarah, Mahfuz, Mustafa, Marie, Chelsea, Moore, Sean R, Nataro, James P, Petri, William A, Sullivan, Peter B, Tarr, Phillip I, Ahmed, Kumail, Alam, Md Ashraful, Barnes, Barrett H, Begum, SM Khodeza Nahar, Borowitz, Stephen M, Chandwe, Kanta, Chipunza, Miyoba, Das, Subhasish, Denson, Lee A, Donowitz, Jeffrey R, Fahim, Shah Mohammad, Gazi, Md Amran, Gilchrist, Carol A, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Mann, Barbara J, Mazumder, Ramendra Nath, Memon, Waheeda, Middleton, Jeremy P, Nayak, Uma, Oliphant, Sandra, Qureshi, Abdul Khalique, Rahman, Masudur, Rahman, Najeeb, Ramakrishnan, Girija, Sadiq, Kamran, Sarker, Shafiqul Alam, and Umrani, Fayaz

Abstract

Environmental enteric dysfunction (EED) is an asymptomatic acquired disorder characterized by upper small bowel inflammation, villus blunting, and gut permeability. It is a major contributor to poor growth in childhood as well as other highly consequential outcomes such as delayed neuorcognitive development. After decades of intermittent interest in this entity, we are now seeing a resurgence in the field of EED. However, recent studies have been hampered by a lack of investigation of the target tissue—the upper small bowel. In 2016, the EEDBI (Environmental Enteric Dysfunction Biopsy Initiative) Consortium was established as a common scientific platform across 3 independent EED biopsy cohort studies in Bangladesh, Pakistan, and Zambia. Two centers in the United States recruited comparison groups of children undergoing endoscopy for clinical indications. The EEDBI Consortium goal was to augment the contributions of the individual centers and answer high-level questions amenable to analysis and interpretation across the studies. Here, we describe the Consortium and its cohorts and recruitment procedures across studies. We also offer details applicable to all papers in this supplement, which describe EED mucosal histology, morphometry, immunohistochemistry, and transcriptomics as well as histology relationship to pathogens and biomarkers.

Published
2024
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22. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Author

Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Ali, S Asad, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, and Yilmaz, Omer H.

Abstract

Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic systemic inflammation.

Published
2024
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23. Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis

Author

Ehsan, Lubaina, Coomes, David, Kelly, Paul, Greene, Adam R, Ali, S Asad, Mulenga, Chola, Denno, Donna M, VanBuskirk, Kelley, Raghib, Muhammad Faraz, Mahfuz, Mustafa, Moore, Sean R, Hossain, Md Shabab, Ahmed, Tahmeed, Sullivan, Peter B, Moskaluk, Christopher A, Syed, Sana, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Begum, SM Khodeza Nahar, Das, Subhasish, Denson, Lee A, Fahim, Shah Mohammad, Gazi, Md Amran, Hasan, Md Mehedi, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jamil, Zehra, Kabir, Furqan, Liu, Ta-Chiang, Mazumder, Ramendra Nath, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Tarr, Phillip I, Tearney, Guillermo J, Umrani, Fayaz, Umutesi, Grace, and Yilmaz, Omer H

Abstract

Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes.

Published
2024
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24. Self-attentive Adversarial Stain Normalization

Author

Shrivastava, Aman, primary, Adorno, William, additional, Sharma, Yash, additional, Ehsan, Lubaina, additional, Ali, S. Asad, additional, Moore, Sean R., additional, Amadi, Beatrice, additional, Kelly, Paul, additional, Syed, Sana, additional, and Brown, Donald E., additional

Published
2021
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27. List of Contributors

Author

Acosta, Anna M., primary, Acuin, Jose M., additional, Adam, Rodney D., additional, Afroze, Farzana, additional, Ahmed, Nadia, additional, Ahmed, Sabeena, additional, Ahmed, Tahmeed, additional, Ahmed, A.M. Shamsir, additional, Ali, S. Asad, additional, Ali, Ibne K., additional, Alroy, Karen A., additional, Ananthakrishnan, Ashwin N., additional, Ansong, Daniel, additional, Anstead, Gregory M., additional, Appleby, Laura J., additional, Armah, George E., additional, Aronson, Naomi E., additional, Aston, Stephen J., additional, Barnett, Elizabeth D., additional, Bartelt, Luther A., additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Beadling, Charles W., additional, Beeching, Nicholas J., additional, Bennish, Michael L., additional, Bern, Caryn, additional, Bernstein, Wendy B., additional, Bird, Brian H., additional, Bloom, Allyson K., additional, Bodeker, Gerard, additional, Boyer Chammard, Timothée, additional, Bradsher, Robert W., additional, Brooker, Simon J., additional, Brooks, W. Abdullah, additional, Brouqui, Philippe, additional, Brown, Michael, additional, Brown, Michael R., additional, Broyles, Laura N., additional, Bruschi, Fabrizio, additional, Bundy, Donald A.P., additional, Burton, Matthew, additional, Cabrera-Sosa, Luis, additional, Callahan, Michael V., additional, Carapetis, Jonathan R., additional, Cardemil, Cristina V., additional, Carrol, Enitan D., additional, Caswell, Rachel, additional, Caumes, Eric, additional, Cavalheiro, Ana P., additional, Chan, Abner L., additional, Charunwatthana, Prakaykaew, additional, Checkley, Anna M., additional, Chen, Lin H., additional, Chher, Tepirou, additional, Chiong, Charlotte M., additional, Chisti, M. Jobayer, additional, Christiani, David C., additional, Clark, Taryn N., additional, Connor, Bradley A., additional, Conway, Devin J., additional, Cooper, Philip J., additional, Cope, Jennifer R., additional, Coughlin, R. Richard, additional, Coulibaly, Yaya I., additional, Coyle, Christina M., additional, Crozier, Ian, additional, Cunliffe, Nigel A., additional, Cupido, Blanche, additional, Curren, Emily J., additional, Danta, Mark, additional, Day, Nicholas P.J., additional, Debboun, Mustapha, additional, DeFraites, Robert F., additional, Dekumyoy, Paron, additional, del Castillo, Maria, additional, den Hoed, Caroline M., additional, de Silva, Nilanthi, additional, Deye, Gregory, additional, Dillingham, Rebecca A., additional, Drancourt, Michel, additional, Durward, Callum S., additional, Eddleston, Michael, additional, El-Kamary, Samer S., additional, Elshaboury, Ramy H., additional, Endtz, Hubert P., additional, Endy, Timothy P., additional, Fang, Shona C., additional, Fawzi, Wafaie, additional, Feasey, Nicholas A., additional, Field, Vanessa K., additional, Fischer, Marc, additional, Forsyth, Kevin, additional, Fournier, Pierre-Edouard, additional, Friedlander, Arthur M., additional, Furin, Jennifer J., additional, Gandhi, Ronak G., additional, Garcia, Hector H., additional, Garcia, Lynne S., additional, Geretti, Anna Maria, additional, Gikas, Achilleas, additional, Gilman, Robert H., additional, Giri, Sidhartha, additional, Gkika, Meropi, additional, Gordon, Melita A., additional, Gosselin, Richard A., additional, Gotuzzo, Eduardo, additional, Gould, Carolyn V., additional, Graeff-Teixeira, Carlos, additional, Graham, Stephen M., additional, Grant, Alison D., additional, Graybill, John R., additional, Graz, Bertrand, additional, Green, Stephen T., additional, Griffiths, Jeffrey K., additional, Griffiths, Michael J., additional, Gryseels, Bruno, additional, Gubler, Duane J., additional, Guhadasan, Rathi, additional, Hall, Aron J., additional, Hamer, Davidson H., additional, Hand, Robert M., additional, Harley, David, additional, Harris, Jason B., additional, Hassall, Oliver, additional, Hay, Roderick J., additional, Hickey, Patrick, additional, Hill, David R., additional, Hills, Susan L., additional, Hobdell, Martin H., additional, Hochberg, Natasha S., additional, Hopkins, Donald R., additional, Hossain, M. Iqbal, additional, Hotez, Peter J., additional, Howard, Cynthia R., additional, Hu, Victor, additional, Hung, Chien-Ching, additional, Islam, Munirul, additional, Iturriza-Gómara, Miren, additional, Joekes, Elizabeth, additional, Johnston, Victoria, additional, Jose, Jo-Ann, additional, Junghanss, Thomas, additional, Kamgno, Joseph, additional, Kampondeni, Sam, additional, Kang, Gagandeep, additional, Kazanjian, Powel, additional, Keshtkar-Jahromi, Maryam, additional, Keshtkar-Jahromi, Marzieh, additional, Keystone, Jay S., additional, Kim, Arthur Y., additional, Kim, Sung-Han, additional, King, Christopher L., additional, Kittitrakul, Chatporn, additional, Kleine, Christian, additional, Klion, Amy D., additional, Knight, Richard, additional, Koren, Michael, additional, Kottilil, Shyamasundaran, additional, Krause, Peter J., additional, Krishna, Sanjeev, additional, Kuhn, Jens H., additional, Kuipers, Ernst J., additional, LaBeaud, Angelle D., additional, Labra, Patrick John P., additional, Lalloo, David G., additional, Lambert, Saba, additional, Lanternier, Fanny, additional, LaRocque, Regina C., additional, Last, Anna, additional, Lawrenson, John, additional, Le, Thuy, additional, Lee, Keun Hwa, additional, Lewis, David A., additional, Libraty, Daniel H., additional, Lo, Nathan C., additional, Lockwood, Diana N.J., additional, Lockwood, Stephen J., additional, Lommerse, Kinke, additional, López-Vélez, Rogelio, additional, Lortholary, Olivier, additional, Mabey, David, additional, Magill, Alan J., additional, Maguiña, Ciro P., additional, Manji, Hadi, additional, Marks, Michael, additional, Maurin, Max, additional, Mayaud, Philippe, additional, Mayosi, Bongani M., additional, M'baya, Bridon, additional, McCarthy, Matthew W., additional, McCartney, Daniel, additional, McCormick, Joseph B., additional, McKew, Stephen, additional, McLellan, Susan L.F., additional, McMinn, Peter C., additional, Mertz, Gregory, additional, Milner, Danny A., additional, Molyneux, Elizabeth M., additional, Montgomery, Susan P., additional, Moonah, Shannon, additional, Moss, William J., additional, Murrell, K. Darwin, additional, Nanda, Neha, additional, Navarro, Eileen E., additional, Ndayizeye, Leonard, additional, Neafie, Ronald C., additional, Negroni, Ricardo, additional, Nelson, Ann M., additional, Newton, Paul N., additional, Nichol, Stuart T., additional, Norman, Francesca F., additional, Nunes, Marcio R.T., additional, Nutman, Thomas B., additional, Nyirenda, Tonney S., additional, Ochoa, Theresa J., additional, O'Farrell, Nigel, additional, Olayemi, Edeghonghon, additional, Oldfield, Edward C., additional, Omidian, Zahra, additional, Ordaya, Eloy E., additional, Paddock, Christopher D., additional, Paessler, Slobodan, additional, Papanikolaou, Ilias C., additional, Paris, Luc, additional, Parry, Christopher M., additional, Patel, Pragna, additional, Peacock, Sharon J., additional, Peeling, Rosanna W., additional, Persson, Hans, additional, Phillips, Jonathan J., additional, Phillips, Richard O., additional, Poovorawan, Kittiyod, additional, Powers, Ann M., additional, Qamar, Farah Naz, additional, Qureshi, Sonia, additional, Rabe, Ingrid B., additional, Rahman, Atif, additional, Rahmati, Elham, additional, Raizes, Elliot, additional, Ramalho-Ortigao, Marcelo, additional, Raoult, Didier, additional, Rein, Michael F., additional, Retik, Alan B., additional, Reynes, Jean-Marc, additional, Rhatigan, Joseph J., additional, Rickard, Jennifer, additional, Riddle, Mark S., additional, Rimoin, Anne W., additional, Riviello, Robert, additional, Robert, Leon L., additional, Rodrigues, Ema G., additional, Rodriguez, Rubens, additional, Ronald, Allan R., additional, Rosenthal, Benjamin M., additional, Rosmarin, David, additional, Ryan, Edward T., additional, Saavedra, Arturo, additional, Schiaffino, Francesca, additional, Schumacher, Sandra K., additional, Sejvar, James J., additional, Sethi, Aisha, additional, Seung, Kwonjune J., additional, Seydel, Karl B., additional, Shah, Melisa M., additional, Shakoor, Sadia, additional, Shankar, Anuraj H., additional, Sharp, Trueman W., additional, Shin, Sonya S., additional, Shirley, Debbie-Ann, additional, Silachamroon, Udomsak, additional, Smith, Catherine C., additional, Snelling, Thomas L., additional, Solomon, Tom, additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Steiger, Samantha N., additional, Stewart, Robert C., additional, Stich, August, additional, Strickman, Daniel, additional, Suh, Kathryn N., additional, Suhrbier, Andreas, additional, Sutcliffe, Catherine G., additional, Tappe, Dennis, additional, Taylor, Terrie E., additional, Thanh, Nguyen Tat, additional, Thanh, Nguyen Thi, additional, Thwaites, C. Louise, additional, Thwaites, Guy E., additional, Tiwari, Tejpratap S.P., additional, Tsenempi, Xenia A., additional, Turner, Angus W., additional, van den Broek, Nynke R., additional, van Doorn, H. Rogier, additional, Van Sickels, Nicholas J., additional, Vannier, Edouard, additional, Varda, Briony K., additional, Vasconcelos, Pedro F.C., additional, Vega-López, Francisco, additional, Vietri, Nicholas J., additional, Vinetz, Joseph M., additional, Visvesvara, Govinda S., additional, Vyas, Keyur S., additional, Walsh, Thomas J., additional, Wansbrough-Jones, Mark H., additional, Warraich, Haider J., additional, Warrell, David A., additional, Warrell, Mary J., additional, Watt, George, additional, Wattanagoon, Yupaporn, additional, Watthanakulpanich, Dorn, additional, Weaver, Scott C., additional, Weil, Ana A., additional, Weiss, Louis M., additional, White, Nicholas J., additional, Whitty, Christopher J.M., additional, Wilson, Mary E., additional, Xavier, Ramnik J., additional, Xiao, Lihua, additional, Yoon, In-Kyu, additional, Yu, Hongjie, additional, and Zaidi, Anita K.M., additional

Published
2020
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32. Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation

Author

Iqbal, Najeeha T., Syed, Sana, Sadiq, Kamran, Khan, Marium N., Iqbal, Junaid, Ma, Jennie Z., Umrani, Fayaz, Ahmed, Sheraz, Maier, Elizabeth A., Denson, Lee A., Haberman, Yael, McNeal, Monica M., Setchell, Kenneth D. R., Zhao, Xueheng, Qureshi, Shahida, Shen, Lanlan, Moskaluk, Christopher A., Liu, Ta-Chiang, Yilmaz, Omer, Brown, Donald E., Barratt, Michael J., Kung, Vanderlene L., Gordon, Jeffrey I., Moore, Sean R., and Ali, S. Asad

Published
2019
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33. Natural Radioactivity, Radon Exhalation Rates and Radiation Doses in the Soil Samples Collected from the Vicinity of Kolaghat Thermal Power Plant, West Bengal, India.

Author

Sharma, Roshan Lal, Mahur, Ajay Kumar, Mehra, Rohit, Chand, Sansar, Ali, S. Asad, Gupta, D. Sen, and Singh, Hargyan

Subjects
RADIOACTIVITY, SOIL sampling, RADIATION, OCEAN thermal power plants
Abstract

Natural radioactivity has been determined by means of a highly efficient thallium-doped sodium iodide detector in soil sample from surface of from vicinage of "Kolaghat Thermal Power Plant" The activity concentration (specific activity) is found to vary from 23.70 ± 3.41 to 33.90 ± 4.33 Bqkg-1 for 226Ra, from 6.67 ± 2.01 to 21.60 ± 2.11 Bqkg-1 for 232Th and that for 40K from 461.01 ± 66.16 to 610.25 ± 80.87 Bqkg-1 with expected value of 29.26 ± 3.50, 4.86 ± 2.03 and 517.53 ± 71.61 Bqkg-1 of Radium-226, Thorium-232 and Potassium-40 correspondingly. The radon exhalation rates were also computed from all samples using the "Sealed Can Technique". The activity due to radon fluctuates from 47.9 ± 6.2 to 157.6 ± 11.3 Bqm-3 having an arithmetic mean of 89.3 ± 7.9 Bqm-3. The surface exhalation rate and mass exhalation rates were estimated to fluctuate from17.3 ± 2.2 to 56.8 ± 4.1 mBqm-2h-1 with an expectation of 32.1 ± 3.0 mBqm-2h-1 and from 0.6 ± 0.1 to 2.1 ± 0.2 mBqkg-1h-1 averaged out to 1.2 ± 0.1 mBqkg-1h-1respectively. Radiation doses were also calculated in these samples. Indoor and outdoor annual effective doses, Absorbed dose rates, External Hazard index and Indoor inhalation exposure, also known as radon effective dose, was computed and varied from 0.19 to 0.25 mSv y-1, 39.30 to 51.61 nGyh-1, 0.048 to 0.063 mSvy-1, 0.21 to 0.28 and 0.29 to 0.36 and 2.04 to 6.70 µSvy-1 respectively. The values which were obtained in this study are found to be well below the allowed permissible limits, so the soil may be used as building construction material. [ABSTRACT FROM AUTHOR]

Published
2023
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37. List of Contributors

Author

Acuin, Jose M, primary, Adam, Rodney D, additional, Agbenyega, Tsiri, additional, Ahmed, AM Shamsir, additional, Ahmed, Tahmeed, additional, Ali, S Asad, additional, Anstead, Gregory M, additional, Armah, George E, additional, Aston, Stephen J, additional, Ballard, Ronald C, additional, Barnett, Elizabeth D, additional, Bates, Imelda, additional, Beadling, Charles W, additional, Beeching, Nicholas J, additional, Bennish, Michael L, additional, Bern, Caryn, additional, Bia, Frank J, additional, Bird, Brian H, additional, Bloom, Allyson K, additional, Bodeker, Gerard, additional, Bradsher, Robert W, additional, Broek, Nynke van den, additional, Brooker, Simon, additional, Brooks, John T, additional, Brooks, W Abdullah, additional, Brouqui, Philippe, additional, Brown, Michael, additional, Bruschi, Fabrizio, additional, Bundy, Donald AP, additional, Bunnag, Danai, additional, Caballero, Benjamin, additional, Callahan, Michael V, additional, Camerlin, Aulasa J, additional, Campbell, Grant L, additional, Carapetis, Jonathan R, additional, Carrol, Enitan D, additional, Caumes, Eric, additional, Charrel, Remi N, additional, Checkley, Anna M, additional, Chhabra, Mala, additional, Chher, Tepirou, additional, Chiong, Charlotte M, additional, Chisti, M Jobayer, additional, Christiani, David C, additional, Connor, Bradley A, additional, Cooper, Edward S, additional, Cooper, Philip J, additional, Coughlin, R Richard, additional, Cross, John H, additional, Cunliffe, Nigel N, additional, Danta, Mark, additional, Day, Nicholas PJ, additional, Dekumyoy, Paron, additional, deSilva, Nilanthi, additional, Deye, Gregory, additional, Dillingham, Rebecca, additional, Doorn, H Rogier van, additional, Doudier, Barbara, additional, Drancourt, Michel, additional, Dromer, Françoise, additional, Eddleston, Michael, additional, El-Kamary, Samer S, additional, Farrar, Jeremy, additional, Fawzi, Wafaie, additional, Feasey, Nicholas A, additional, Field, Vanessa, additional, Fischer, Marc, additional, Fisher-Hoch, Susan, additional, Forsyth, Kevin, additional, Fox, LeAnne M, additional, Friedlander, Arthur M, additional, Galdos-Cardenas, Gerson, additional, Garcia, Hector H, additional, Garcia, Lynne S, additional, Geretti, Anna-Maria, additional, Gikas, Achilleas, additional, Gilman, Robert H, additional, Gonzalez, Victor Javier Sanchez, additional, Gordon, Melita A, additional, Gosselin, Richard A, additional, Graham, Stephen M, additional, Grant, Alison D, additional, Gray, James J, additional, Graybill, John R, additional, Graz, Bertrand, additional, Green, Stephen, additional, Griffiths, Jeffrey K, additional, Gryseels, Bruno, additional, Gubler, Duane J, additional, Guhadasan, Rathi, additional, Hall, Aron J, additional, Hamer, Davidson, additional, Harley, David, additional, Harris, Jason B, additional, Hartman, Amy L, additional, Hassall, Oliver, additional, Hay, Roderick J, additional, Heyns, Chris F, additional, Hill, David R, additional, Hobdell, Martin H, additional, Hoed, Caroline M den, additional, Holtz, Meredith L, additional, Hossain, M Iqbal, additional, Hotez, Peter J, additional, Houpt, Eric R, additional, Howard, Cynthia R, additional, Hung, Chien-Ching, additional, Islam, Munirul, additional, Joekes, Elizabeth, additional, Johnston, Victoria, additional, Kampondeni, Sam, additional, Kang, Gagandeep, additional, Kazanjian, Powel, additional, Keystone, Jay S, additional, Khan, Wasif Ali, additional, Kim, Arthur Y, additional, King, Christopher L, additional, Klion, Amy D, additional, Knight, Richard, additional, Krause, Peter James, additional, Krishna, Sanjeev, additional, Kuipers, Ernst J, additional, LaBeaud, Angelle D, additional, Lalloo, David G, additional, Lamballerie, Xavier De, additional, Lambert, Saba, additional, LaRocque, Regina C, additional, Lawrenson, John, additional, Levine, Myron M, additional, Libraty, Daniel H, additional, Lockwood, Diana NJ, additional, Lommerse, Kinke M, additional, Lortholary, Olivier, additional, López-Vélez, Rogelio, additional, Lopman, Benjamin A, additional, Mabey, David, additional, Magill, Alan J., additional, Maguiña, Ciro, additional, Mahmood, Syed Faisal, additional, Maitland, Kathryn, additional, Manji, Hadi, additional, Marston, Barbara J, additional, Mathew, Anu, additional, Mathews, Christine E, additional, Maurin, Max, additional, Maurtua-Neumann, Paola J, additional, Mayaud, Philippe, additional, Mayosi, Bongani M, additional, McCormick, Joseph B, additional, McKew, Stephen, additional, McLellan, Susan LF, additional, McMinn, Peter C, additional, Mega, Joseph D, additional, Meier, Donald E, additional, Million, Matthieu, additional, Mittal, Veena, additional, Molyneux, Elizabeth M, additional, Montgomery, Susan P, additional, Morera, Pedro, additional, Moro, Pedro L, additional, Moss, William J, additional, Murrell, K Darwin, additional, Nakagomi, Osamu, additional, Nakagomi, Toyoko, additional, Nanda, Neha, additional, Nataro, James P, additional, Navaro, Eileen E, additional, Neafie, Ronald C, additional, Negroni, Ricardo, additional, Nelson, Ann M, additional, Newton, Paul N, additional, Newton, Robert, additional, Nichol, Stuart T, additional, Norman, Francesca F, additional, Nunes, Marcio RT, additional, Nutman, Thomas B, additional, Oberhelman, Richard A, additional, Oldfield, Edward C, additional, Ordaya, Eloy E, additional, Paddock, Christopher D, additional, Paessler, Slobodan, additional, Papanikolaou, Ilias C, additional, Pappas, Georgios, additional, Paris, Luc, additional, Parola, Philippe, additional, Parry, Christopher M, additional, Patel, Manish M, additional, Peacock, Sharon J, additional, Peeling, Rosanna, additional, Persson, Hans, additional, Peters, Philip J, additional, Phillips, Jonathan J, additional, Phillips, Richard O, additional, Qamar, Farah Naz, additional, Rahman, Atif, additional, Rajab, Jamilla, additional, Raoult, Didier, additional, Rein, Michael F, additional, Renvoisé, Aurélié, additional, Reynes, Jean-Marc, additional, Richards, Frank O, additional, Richens, John, additional, Rimoin, Anne W, additional, Riviello, Robert, additional, Rodrigues, Ema G, additional, Ronald, Allan R, additional, Rosenthal, Benjamin M, additional, Rosmarin, David, additional, Ruiz-Tiben, Ernesto, additional, Ryan, Edward T, additional, Saha, Debasish, additional, Saavedra, Arturo, additional, Schantz, Peter M, additional, Schountz, Tony, additional, Schumacher, Sandra K, additional, Sejvar, James J, additional, Sethi, Aisha, additional, Seung, Kwonjune J, additional, Sharma, Om Prakash, additional, Sharp, Trueman W, additional, Shankar, Anuraj H, additional, Shin, Sonya S, additional, Shlim, David R, additional, Sickels, Nicholas J van, additional, Sitas, Freddy, additional, Snelling, Thomas L, additional, Socolovschi, Cristina, additional, Solomon, Tom, additional, Staples, J Erin, additional, Stewart, Robert C, additional, Stich, August, additional, Strickland, G Thomas, additional, Suh, Kathryn N, additional, Suhrbier, Andreas, additional, Supparatpinyo, Khuanchai, additional, Sutcliffe, Catherine G, additional, Swierczewski, Brett E, additional, Tarpley, John L, additional, Taylor, Hugh R, additional, Taylor, Terrie, additional, Thomas, Harry J, additional, Thwaites, C Louise, additional, Thwaites, Guy E, additional, Tiwari, Tejpratap SP, additional, Tu, Phan Van, additional, Turner, Angus W, additional, Vannier, Edouard, additional, Vasconcelos, Pedro FC, additional, Vega-López, Fransisco, additional, Velarde, Jorge J, additional, Vietri, Nicholas J, additional, Visvesvara, Govinda S, additional, Vyas, Keyur S, additional, Wakeham, Katie, additional, Walsh, Thomas J, additional, Wansbrough-Jones, Mark H, additional, Warrell, David A, additional, Warrell, Mary J, additional, Warraich, Haider J, additional, Watt, George, additional, Wattanagoon, Yupaporn, additional, Watthanakulpanich, Dorn, additional, Weaver, Scott C, additional, Webman, Rachel B, additional, Weidle, Paul J, additional, Weiss, Louis M, additional, White, Nicholas J, additional, Whitty, Christopher JM, additional, Woodhall, Dana M, additional, Wright, Stephen G, additional, Xavier, Ramnik J, additional, Xiao, Lihua, additional, Yu, Hongjie, additional, and Zaidi, Anita KM, additional

Published
2013
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38. Artificial Intelligence-Based Analytics for Diagnosis of Small Bowel Enteropathies and Black Box Feature Detection

Author

Syed, Sana, primary, Ehsan, Lubaina, additional, Shrivastava, Aman, additional, Sengupta, Saurav, additional, Khan, Marium, additional, Kowsari, Kamran, additional, Guleria, Shan, additional, Sali, Rasoul, additional, Kant, Karan, additional, Kang, Sung-Jun, additional, Sadiq, Kamran, additional, Iqbal, Najeeha T., additional, Cheng, Lin, additional, Moskaluk, Christopher A., additional, Kelly, Paul, additional, Amadi, Beatrice C., additional, Ali, S. Asad, additional, Moore, Sean R., additional, and Brown, Donald E., additional

Published
2020
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39. Machine Learning Model Demonstrates Stunting at Birth and Systemic Inflammatory Biomarkers as Predictors of Subsequent Infant Growth – A Four-year Prospective Study.

Author

Harrison, Elizabeth, primary, Syed, Sana, additional, Ehsan, Lubaina, additional, Iqbal, Najeeha T., additional, Sadiq, Kamran, additional, Umrani, Fayyaz, additional, Ahmed, Sheraz, additional, Rahman, Najeeb, additional, Jakhro, Sadaf, additional, Jennie, Z., additional, Hughes, Molly, additional, and Ali, S. Asad, additional

Published
2020
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40. Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting

Author

Ibrahim, Romesa, Ali, S. Asad, Kazi, A. Momin, Rizvi, Arjumand, Guterman, L. Beryl, Bednarczyk, Robert A., Kim, Ellie, Park, SoHee, Paulos, Simon, Jeyachandran, Amilia, Patel, Divya, Gorantla, Yamini, Wong, Emily, Rajam, Gowrisankar, Schiffer, Jarad, and Omer, Saad B.

Subjects
DTwP, Adult, Male, Adolescent, Infant, Newborn, Infant, Maternal vaccination, Immunogenicity, Antibodies, Bacterial, Article, Pertussis vaccine, Cohort Studies, Young Adult, Treatment Outcome, Immune blunting, Pregnancy, Humans, Female, Pakistan, Developing Countries, Immunity, Maternally-Acquired, Diphtheria-Tetanus-Pertussis Vaccine, Immunization Schedule
Abstract

Background Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6–10–14 weeks of age. Methodology A total of 261 pregnant women and their infants from four low-income settlements in Karachi, Pakistan were enrolled in this study. The study endpoints were infant antibody titers for Pertussis toxin (PTx), Filamentous hemagglutinin antigen (FHA), Pertactin (PRN) and Fimbriae type 2/3 (FIM) – from birth through 18 weeks of age. Cord blood or pre-vaccine pertussis antibody titers indicate the concentration of maternal antibodies transferred to infants. Linear regression models were used to determine the association between higher maternal antibody titers and infant immune response to DTwP vaccine. Geometric Mean Ratio (GMR) was calculated as the ratio of infant antibody titers at specified time points against the maternal antibody titers at the time of delivery. Results At eighteen weeks of age, the adjusted β regression coefficient for PTx was 0.06 (95% CI: -0.49-0.61), FHA 0.02 (95% CI: -0.26 -0.29), PRN 0.02 (95%CI -0.38- 0.43), and FIM 0.17 (95%CI: -0.21-0.54). Among infants who received at least two doses of DTwP vaccine, higher maternal antibody titers did not have any attenuating effect on infant post-immunization antibody titers against all four pertussis antigens. Conclusion Maternal pertussis antibodies did not attenuate infant’s immune response to pertussis antigens in DTwP primary vaccine given at 6–10–14 weeks of age.

Published
2018

41. Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Testing in a Low Resource Population

Author

Omer, Saad B., Bednarczyk, Robert, Kazi, Momin, Guterman, L. Beryl, Aziz, Fatima, Allen, Kristen E., Yildirim, Inci, and Ali, S. Asad

Subjects
syndromic case definition, RSV, Infant, Respiratory Syncytial Virus Infections, Nasopharynx, Population Surveillance, Respiratory Syncytial Virus, Human, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, surveillance, Health Resources, Humans, Brief Reports, Pakistan, Prospective Studies, Public Health
Abstract

Supplemental Digital Content is available in the text., Standardized case definitions are needed in decision-making regarding respiratory syncytial virus control strategies, including vaccine evaluation. A syndromic case definition comprising of “wheeze or apnea or cyanosis” could be useful for community-based surveillance of moderate respiratory syncytial virus infection among young infants particularly in resource-limited settings. However, this definition showed modest specificity (29.2%–49.6%), indicating that community-based surveillance may need augmentation with other data.

Published
2018

47. Serum anti-flagellin and anti-lipopolysaccharide immunoglobulins as predictors of linear growth faltering in Pakistani infants at risk for environmental enteric dysfunction

Author

Syed, Sana, primary, Iqbal, Najeeha T., additional, Sadiq, Kamran, additional, Ma, Jennie Z., additional, Akhund, Tauseef, additional, Xin, Wenjun, additional, Moore, Sean R., additional, Liu, Enju, additional, Qureshi, Shahida, additional, Gosselin, Kerri, additional, Gewirtz, Andrew, additional, Duggan, Christopher P., additional, and Ali, S. Asad, additional

Published
2018
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