Search

Your search keyword '"Alfaar, A. S."' showing total 30 results
Start Over Author "Alfaar, A. S."
30 results on '"Alfaar, A. S."'

1. Trends in childhood cancer: Incidence and survival analysis over 45 years of SEER data.

Author

Sultan, Iyad, Alfaar, Ahmad S., Sultan, Yaseen, Salman, Zeena, and Qaddoumi, Ibrahim

Subjects
*CHILDHOOD cancer, *CHILD patients, *GERM cell tumors, *CANCER patients, *BLACK children, *COVID-19
Abstract

Background: The SEER Registry contains U.S. cancer statistics. To assess trends in incidence and survival and the impact of demographic factors among pediatric patients with cancer, we assessed nearly 5 decades (1975–2019) of data. Methods: All patients below the age of 20 with histology-confirmed malignancy were studied. Kaplan-Meier survival curves were generated to evaluate survival trends across treatment periods and ICCC classes. JoinPoint analysis was conducted to identify changes in incidence and survival. Results: The incidence of childhood cancer increased from 14.23 cases per 100,000 children in 1975–1979 to 18.89 in 2010–2019, with an average annual percent change of 0.73. This rise was more pronounced in several cancers, including leukemias, lymphomas, brain tumors, hepatic tumors, and gonadal germ cell tumors. Age-adjusted cancer mortality decreased from 4.9 to 2.3 per 100,000. Cancer-related mortality was consistently higher in boys than in girls, and in Black children than in White children. Survival significantly improved, with 5- and 10-year survival rates rising from 63.1% to 85.2% and from 58.8% to 82.7%, respectively. Leukemias showed a substantial increase in 5-year survival from 48.2% ± 1.7% to 85.1% ± 0.4% in 2010–2019. Lymphomas also showed significant improvement, with survival increasing from 72.9% ± 1.7% to 94.2% ± 0.3%. Despite these improvements, the survival of CNS tumors, bone tumors, and sarcomas remained suboptimal, with 5-year survival estimates of approximately 60%. Our joinpoint analysis confirmed our findings but revealed an interesting increase in the incidence of lymphomas limited to the years between 2005 and 2014. Conclusion: This research elucidates advancements in survival among pediatric patients with cancer. The results offer critical perspectives on pediatric oncology, highlighting the imperative for ongoing innovation in therapeutics. Although the increase in incidence may partially stem from enhanced diagnostic capabilities and more comprehensive registration processes, the underlying causes remain unclear. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

4. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

Author

Bourne R. R. A., Steinmetz J. D., Saylan M., Mersha A. M., Weldemariam A. H., Wondmeneh T. G., Sreeramareddy C. T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zimsen S. R. M., Yonemoto N., Tsegaye G. W., Vu G. T., Vongpradith A., Renzaho A. M. N., Sorrie M. B., Shaheen A. A., Shiferaw W. S., Skryabin V. Y., Skryabina A. A., Saya G. K., Rahimi-Movaghar V., Shigematsu M., Sahraian M. A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T. R., Rezapour A., Rawal L., Pham H. Q., Parekh U., Podder V., Onwujekwe O. E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M. D., Al Montasir A., Ogbo F. A., Owolabi M. O., Pakshir K., Mohammad Y., Moni M. A., Nunez-Samudio V., Mulaw G. F., Naveed M., Maleki S., Michalek I. M., Misra S., Swamy S. N., Mohammed J. A., Flaxman S., Park E. -C., Briant P. S., Meles G. G., Hayat K., Landires I., Kim G. R., Liu X., LeGrand K. E., Taylor H. R., Kunjathur S. M., Khoja T. A. M., Bicer B. K., Khalilov R., Hashi A., Kayode G. A., Carneiro V. L. A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S. M. S., Gilani S. A., Eskandarieh S., Molla M. D., Itumalla R., Farzadfar F., Congdon N. G., Elhabashy H. R., Elayedath R., Couto R. A. S., Dervenis N., Cromwell E. A., Dahlawi S. M. A., Resnikoff S., Casson R. J., Abdoli A., Choi J. -Y. J., Dos Santos F. L. C., Abrha W. A., Nagaraja S. B., Abualhasan A., Adal T. G., Aregawi B. B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S. A., Arrigo A., Atnafu D. D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A. S., Alipour V., Anbesu E. W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A. A., Barnighausen T. W., Battaglia Parodi M., Bhagavathula A. S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A. M., Butt Z. A., Cheng C. -Y., Chu D. -T., Cicinelli M. V., Coelho J. M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M. A., Deva J. P., Diaz D., Djalalinia S., Dreer L. E., Ehrlich J. R., Ellwein L. B., Emamian M. H., Fernandes A. G., Fischer F., Friedman D. S., Furtado J. M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B. R., Hartnett M. E. R., Hartono R. K., Hay S. I., Heidari G., Ho H. C., Househ M., Ibitoye S. E., Ilic I. M., Huang J. J., Ilic M. D., Ingram A. D., Irvani S. S. N., Jha R. P., Kahloun R., Kandel H., Kasa A. S., Kempen J. H., Khairallah M., Khan E. A., Khanna R. C., Khatib M. N., Kim J. E., Kim Y. J., Kisa A., Kisa S., Koyanagi A., Kurmi O. P., Lansingh V. C., Leasher J. L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S. F., Mokdad A. H., Morse A. R., Naderi M., Naidoo K. S., Nangia V., Nguyen H. L. T., Ogundimu K., Olagunju A. T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M. H., Ramulu P. Y., Rawaf D. L., Rawaf S., Reinig N., Robin A. L., Rossetti L., Safi S., Sahebkar A., Samy A. M., Serle J. B., Shaikh M. A., Shen T. T., Shibuya K., Shin J. I., Silva J. C., Silvester A., Singh J. A., Singhal D., Sitorus R. S., Skiadaresi E., Soheili A., Sousa R. A. R. C., Stambolian D., Tadesse E. G., Tahhan N., Tareque Md. I., Topouzis F., Tran B. X., Tsilimbaris M. K., Varma R., Virgili G., Wang N., Wang Y. X., West S. K., Wong T. Y., Jonas J. B., Vos T., Bourne, R. R. A., Steinmetz, J. D., Saylan, M., Mersha, A. M., Weldemariam, A. H., Wondmeneh, T. G., Sreeramareddy, C. T., Pinheiro, M., Yaseri, M., Yu, C., Zastrozhin, M. S., Zastrozhina, A., Zhang, Z. -J., Zimsen, S. R. M., Yonemoto, N., Tsegaye, G. W., Vu, G. T., Vongpradith, A., Renzaho, A. M. N., Sorrie, M. B., Shaheen, A. A., Shiferaw, W. S., Skryabin, V. Y., Skryabina, A. A., Saya, G. K., Rahimi-Movaghar, V., Shigematsu, M., Sahraian, M. A., Naderifar, H., Sabour, S., Rathi, P., Sathian, B., Miller, T. R., Rezapour, A., Rawal, L., Pham, H. Q., Parekh, U., Podder, V., Onwujekwe, O. E., Pasovic, M., Otstavnov, N., Negash, H., Pawar, S., Naimzada, M. D., Al Montasir, A., Ogbo, F. A., Owolabi, M. O., Pakshir, K., Mohammad, Y., Moni, M. A., Nunez-Samudio, V., Mulaw, G. F., Naveed, M., Maleki, S., Michalek, I. M., Misra, S., Swamy, S. N., Mohammed, J. A., Flaxman, S., Park, E. -C., Briant, P. S., Meles, G. G., Hayat, K., Landires, I., Kim, G. R., Liu, X., Legrand, K. E., Taylor, H. R., Kunjathur, S. M., Khoja, T. A. M., Bicer, B. K., Khalilov, R., Hashi, A., Kayode, G. A., Carneiro, V. L. A., Kavetskyy, T., Kosen, S., Kulkarni, V., Holla, R., Kalhor, R., Jayaram, S., Islam, S. M. S., Gilani, S. A., Eskandarieh, S., Molla, M. D., Itumalla, R., Farzadfar, F., Congdon, N. G., Elhabashy, H. R., Elayedath, R., Couto, R. A. S., Dervenis, N., Cromwell, E. A., Dahlawi, S. M. A., Resnikoff, S., Casson, R. J., Abdoli, A., Choi, J. -Y. J., Dos Santos, F. L. C., Abrha, W. A., Nagaraja, S. B., Abualhasan, A., Adal, T. G., Aregawi, B. B., Beheshti, M., Abu-Gharbieh, E., Afshin, A., Ahmadieh, H., Alemzadeh, S. A., Arrigo, A., Atnafu, D. D., Ashbaugh, C., Ashrafi, E., Alemayehu, W., Alfaar, A. S., Alipour, V., Anbesu, E. W., Androudi, S., Arabloo, J., Arditi, A., Bagli, E., Baig, A. A., Barnighausen, T. W., Battaglia Parodi, M., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bijani, A., Bikbov, M., Bottone, M., Braithwaite, T., Bron, A. M., Butt, Z. A., Cheng, C. -Y., Chu, D. -T., Cicinelli, M. V., Coelho, J. M., Dai, X., Dana, R., Dandona, L., Dandona, R., Del Monte, M. A., Deva, J. P., Diaz, D., Djalalinia, S., Dreer, L. E., Ehrlich, J. R., Ellwein, L. B., Emamian, M. H., Fernandes, A. G., Fischer, F., Friedman, D. S., Furtado, J. M., Gaidhane, S., Gazzard, G., Gebremichael, B., George, R., Ghashghaee, A., Golechha, M., Hamidi, S., Hammond, B. R., Hartnett, M. E. R., Hartono, R. K., Hay, S. I., Heidari, G., Ho, H. C., Househ, M., Ibitoye, S. E., Ilic, I. M., Huang, J. J., Ilic, M. D., Ingram, A. D., Irvani, S. S. N., Jha, R. P., Kahloun, R., Kandel, H., Kasa, A. S., Kempen, J. H., Khairallah, M., Khan, E. A., Khanna, R. C., Khatib, M. N., Kim, J. E., Kim, Y. J., Kisa, A., Kisa, S., Koyanagi, A., Kurmi, O. P., Lansingh, V. C., Leasher, J. L., Leveziel, N., Limburg, H., Manafi, N., Mansouri, K., Mcalinden, C., Mohammadi, S. F., Mokdad, A. H., Morse, A. R., Naderi, M., Naidoo, K. S., Nangia, V., Nguyen, H. L. T., Ogundimu, K., Olagunju, A. T., Panda-Jonas, S., Pesudovs, K., Peto, T., Ur Rahman, M. H., Ramulu, P. Y., Rawaf, D. L., Rawaf, S., Reinig, N., Robin, A. L., Rossetti, L., Safi, S., Sahebkar, A., Samy, A. M., Serle, J. B., Shaikh, M. A., Shen, T. T., Shibuya, K., Shin, J. I., Silva, J. C., Silvester, A., Singh, J. A., Singhal, D., Sitorus, R. S., Skiadaresi, E., Soheili, A., Sousa, R. A. R. C., Stambolian, D., Tadesse, E. G., Tahhan, N., Tareque, Md. I., Topouzis, F., Tran, B. X., Tsilimbaris, M. K., Varma, R., Virgili, G., Wang, N., Wang, Y. X., West, S. K., Wong, T. Y., Jonas, J. B., Vos, T., University of Washington [Seattle], Anglia Ruskin University (ARU), Imperial College London, University of Melbourne, Heidelberg University, Jahrom University of Medical Sciences, Aksum University, Cairo University, University of Sharjah, Wolkite University, Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University, The Fred Hollows Foundation, Iran University of Medical Sciences, University of Leipzig Medical Center, University of Thessaly [Volos] (UTH), Visibility Metrics LLC, Adigrat University, San Raffaele Hospital, Tehran University of Medical Sciences (TUMS), Bahir Dar University (BDU), University Hospital of Ioannina, Sultan Zainal Abidin University, Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Charles University [Prague] (CU), Government Medical College Pali, All India Institute of Medical Sciences, National Institute of Biomedical Genomics, Babol University of Medical Sciences, Ufa Eye Research Institute, ondon School of Hygiene & Tropical Medicine, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Employee State Insurance Post Graduate Institute of Medical Sciences and Research, University of Waterloo [Waterloo], Federal Polytechnic School of Lausanne, University of Minho, University of Adelaide, Singapore Eye Research Institute [Singapore] (SERI), Seoul National University Hospital, Hanoi National University of Education (HNUE), IRCCS San Raffaele Scientific Institute [Milan, Italie], University of Porto, Queen's University [Belfast] (QUB), University of Dammam - Imam Abdulrahman Bin Faisal University, Harvard University, University of Michigan [Ann Arbor], University of Michigan System, University of Gondar, Royal Liverpool University Hospital, Universiti Tunku Abdul Rahman (UTAR), National Autonomous University of Mexico (UNAM), Ministry of Health and Medical Education [Iran] (MOHME), Mahatma Gandhi University of Medical Sciences and Technology, Cairo University - Faculty of Medicine, National Institutes of Health [Bethesda] (NIH), Shahroud University of Medical Sciences, Federal University of Sao Paulo (Unifesp), University of Applied Sciences Ravensburg-Weingarten, University of São Paulo (USP), Datta Meghe Institute of Medical Sciences, University College of London [London] (UCL), Haramaya University, Sankara Nethralaya Medical Research Foundation, The University of Lahore, Indian Institute of Public Health Gandhinagar, Hamdan Bin Mohammed Smart University, University of Georgia, University of Utah, Institution of Public Health Sciences, Jigjiga Universit, University of Veterinary and Animal Sciences, Independent Consultant, The Chinese University of Hong Kong [Hong Kong], Manipal academy of Higher Education, Hamad Bin Khalifa University (HBKU), Yale University [New Haven], University of Ibadan, University of Belgrade [Belgrade], Faculty of Science of the University of Kragujevac, University of Kragujevac, Deakin University, Burwood, Australia, Deakin University [Burwood], University of Hail, Mysore Medical College, Banaras Hindu University [Varanasi] (BHU), Ophtalmologistes Associe Monastir, Qazvin University of Medical Sciences, The University of Sydney, John Paul II Catholic University of Lublin (KUL), Institute of Human Virology [Nigeria] (IHVN), Myungsung Medical College, Centre Hospitalier Universitaire Fattouma Bourguiba, Partenaires INRAE, Baku State University, Health Services Academy, L V Prasad Eye Institute, Health Ministers Council Gulf Cooperative Council Stat, Medical College of Wisconsin [Milwaukee] (MCW), Xiamen University Malaysia, Yonsei University, Oslo Metropolitan University (OsloMet), School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia, Brien Holden Vision Institute, Fondation Théa, The Fred Hollows Foundation, Bill & Melinda Gates Foundation, Lions Clubs International Foundation, Sightsavers International, and University of Heidelberg., and GBD 2019 Blindness and Vision Impairment Collaborators* on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study.

Subjects
Pediatrics, medicine.medical_specialty, Refractive error, Visual acuity, genetic structures, Eye disease, 030231 tropical medicine, Population, Glaucoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Global health, 030212 general & internal medicine, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, education, education.field_of_study, business.industry, Articles, General Medicine, Diabetic retinopathy, Macular degeneration, medicine.disease, eye diseases, 3. Good health, medicine.symptom, business
Abstract

Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error. Methods: We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from

Published
2021
Full Text
View/download PDF

5. Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel

Author

Reichhart, Nadine, Schöberl, Simon, Keckeis, Susanne, Alfaar, Ahmad S., Roubeix, Christophe, Cordes, Magdalena, Crespo-Garcia, Sergio, Haeckel, Akvile, Kociok, Norbert, Föckler, Renate, Fels, Gabriele, Mataruga, Anja, Rauh, Robert, Milenkovic, Vladimir M., Zühlke, Kerstin, Klussmann, Enno, Schellenberger, Eyk, and Strauß, Olaf

Published
2019
Full Text
View/download PDF

7. sj-docx-1-ejo-10.1177_11206721221125018 - Supplemental material for The epidemiology of adults' malignant eyelid malignancies in Germany between 2009 and 2015; An analysis of 42,710 patients' data

Author

Alfaar, Ahmad S, Suckert, C Nathanael, Rehak, Matus, and Girbardt, Christian

Subjects
Medicine
Abstract

Supplemental material, sj-docx-1-ejo-10.1177_11206721221125018 for The epidemiology of adults' malignant eyelid malignancies in Germany between 2009 and 2015; An analysis of 42,710 patients' data by Ahmad S Alfaar, C Nathanael Suckert, Matus Rehak and Christian Girbardt in European Journal of Ophthalmology

Published
2022
Full Text
View/download PDF

11. Inhibition of Ca 2+ channel surface expression by mutant bestrophin���1 in RPE cells

Author

Cordes, Magdalena, Bucichowski, Piotr, Alfaar, Ahmad S., Tsang, Stephen H., Almedawar, Seba, Reichhart, Nadine, and Strauß, Olaf

Subjects
surface expression, retinal degeneration, sense organs, bestrophin-1, RPE, CaV1.3, eye diseases, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

The BEST1 gene product bestrophin-1, a Ca2+-dependent anion channel, interacts with CaV1.3 Ca2+ channels in the retinal pigment epithelium (RPE). BEST1 mutations lead to Best vitelliform macular dystrophy. A common functional defect of these mutations is reduced trafficking of bestrophin-1 into the plasma membrane. We hypothesized that this defect affects the interaction partner CaV1.3 channel affecting Ca2+ signaling and altered RPE function. Thus, we investigated the protein interaction between CaV1.3 channels and bestrophin-1 by immunoprecipitation, CaV1.3 activity in the presence of mutant bestrophin-1 and intracellular trafficking of the interaction partners in confluent RPE monolayers. We selected four BEST1 mutations, each representing one mutational hotspot of the disease: T6P, F80L, R218C, and F305S. Heterologously expressed L-type channels and mutant bestrophin-1 showed reduced interaction, reduced CaV1.3 channel activity, and changes in surface expression. Transfection of polarized RPE (porcine primary cells, iPSC-RPE) that endogenously express CaV1.3 and wild-type bestrophin-1, with mutant bestrophin-1 confirmed reduction of CaV1.3 surface expression. For the four selected BEST1 mutations, presence of mutant bestrophin-1 led to reduced CaV1.3 activity by modulating pore-function or decreasing surface expression. Reduced CaV1.3 activity might open new ways to understand symptoms of Best vitelliform macular dystrophy such as reduced electro-oculogram, lipofuscin accumulation, and vision impairment.

Published
2020
Full Text
View/download PDF

12. The outcome of childhood adrenocortical carcinoma in Egypt: A model from developing countries

Author

Zekri, Wael, Hammad, Mahmoud, Rashed, Wafaa M., Gehad Ahmed, Elshafie, Maged, Adly, Marwan H., Elborai, Yasser, Abdalla, Badr, Taha, Hala, Naglaa Elkinaae, Refaat, Amal, Younis, Alaa, and Alfaar, Ahmad S.

Abstract

Adrenocortical carcinoma (ACC) is a rare, aggressive endocrine neoplasm. Complete surgical resection is the single most important treatment. Most available information has been learned from experience with its more frequent adult counterpart. In this study, we assessed the features and survival outcome of patients with ACC at Children’s Cancer Hospital Egypt (CCHE). Patients diagnosed at CCHE between July 2007 and November 2016 were followed up on until November 2018. Patients with stages I and II were operated upon, while stages III and IV had received combinations of doxorubicin, etoposide, platinol, and mitotane (DEPM) beside the attempt to conduct surgery when feasible. Data belonging to 18 patients (7 men and 11 women) were analyzed; median age at diagnosis was 48.5 months. Sixteen patients had presented with secreting tumors. Six patients were diagnosed with stage I disease; four with stage II; three with stage III; and five with stage IV carcinoma. By the end of this study, 10 patients have survived; five-year overall survival of 66.3%. Surviving patients were all of stage I or II diseases and were all in remission. Seven patients who did not survive died due to tumor progression, while one patient died after chemotherapy. The prognosis of ACC is essentially dependent on a successful complete resection of the tumor and thus on the initial tumor stage. The mitotane and DEP protocols may help control tumor growth in the advanced stages for only short periods. Key pointsInitial stage and resectability are the main indicators of outcomes in adrenocortical carcinoma.Chemotherapeutic agents used in developed countries did not achieve the same outcomes.Further molecular-pharmacology differentiation is needed for various ethnic populations. Initial stage and resectability are the main indicators of outcomes in adrenocortical carcinoma. Chemotherapeutic agents used in developed countries did not achieve the same outcomes. Further molecular-pharmacology differentiation is needed for various ethnic populations.

Published
2020
Full Text
View/download PDF

13. The outcome of childhood adrenocortical carcinoma in Egypt: A model from developing countries

Author

Zekri, Wael, primary, Hammad, Mahmoud, additional, Rashed, Wafaa M., additional, Ahmed, Gehad, additional, Elshafie, Maged, additional, Adly, Marwan H., additional, Elborai, Yasser, additional, Abdalla, Badr, additional, Taha, Hala, additional, Elkinaae, Naglaa, additional, Refaat, Amal, additional, Younis, Alaa, additional, and Alfaar, Ahmad S., additional

Published
2020
Full Text
View/download PDF

15. Pediatric ependymoma: A single-center experience from a developing country.

Author

Hammad, Mahmoud, Hosny, Maryhan, Khalil, Ehab M., Alfaar, Ahmad S., and Fawzy, Mohamed

Subjects
CENTRAL nervous system tumors, CENTRAL nervous system cancer, DEVELOPING countries, EPENDYMOMA, SYMPTOMS, TUMORS in children, OVERALL survival, GLIOMAS, SURVIVAL analysis (Biometry)
Abstract

Background: Ependymomas are the third most common pediatric central nervous system (CNS) tumors, accounting for 6-12% of brain tumors in children. Management of these tumors remains challenging and recurrence occurs in over 50% of cases, mainly when complete resection is not achieved before radiotherapy. The 5-year overall survival (OS) ranges from 39 to 64%, with a 5-year progression-free survival (PFS) rate of 23-45%. The study aimed to describe the OS and PFS rates of cases of pediatric ependymoma. It also aimed to evaluate the effects of different variables on disease outcomes. Variables examined included patient age, the extent of surgical resection, radiotherapy and chemotherapy delivered, the histopathological subtype of the tumor, primary tumor location, and extent of the disease at presentation. Last, the challenges that potentially compromise treatment outcomes in resource-limited countries were to be highlighted.Methods: This is a retrospective cohort study, representing a single-center experience that included 47 pediatric patients treated at the National Cancer Institute, Cairo University, between January 2009 and December 2014.Results: Median follow-up stood at 23.5 months (range: 2-77 months). The average 3-year OS and PFS rates were 43.7 and 43.3%, respectively.Conclusion: The extent of surgical excision (maximal resection) and the adequacy of postoperative radiotherapy were the only two factors that had significantly affected the outcome. Understandably, treatment outcomes for ependymomas in developing countries still lag behind best reported outcomes, mainly due to inadequate surgical excision and postoperative radiotherapy. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

27. Clinical Research Recession: Training Needs Perception Among Medical Students.

Author

Alfaar, Ahmad, Hassan, Waleed, Bakry, Mohamed, Ezzat, Sameera, Alfaar, Ahmad S, Hassan, Waleed M, and Bakry, Mohamed S

Subjects
DEVELOPING countries, MEDICAL education, MEDICAL protocols, PSYCHOLOGY of medical students, EVIDENCE-based medicine
Abstract

Clinical research is an integrated part of medical education. There is a noticeable decrease in the number of physician-scientists in developing countries, which is reflected by a decrease in research output and publications from these countries. We conducted a survey aiming to identify the gaps in clinical research training from the perspective of medical students. The results can be used to customize future clinical research trainings. The survey tool was divided into six modules which represent the cornerstones of clinical research based on similar surveys done for the same purpose. For each module, questions covered the perceived knowledge of its aspects and how much relevant the responder thought it was to clinical research. Five hundred one candidates have filled the survey. Evidence-based medicine (EBM) had the highest knowledge score of 2.20/4, while "clinical trials execution" knowledge got the lowest score of 1.64/4. Responders perceived EBM as the most relevant aspect of clinical research (3.39/4), while research ethics received the lowest score 3.18/4. "Clinical trials execution" had the largest gap of a difference calculated as 1.60, while EBM had the lowest gap of 1.20. More attention must be paid to clinical research training for medical students in developing countries. These trainings have to be customized to focus on clinical trial execution, research methodology, and biostatistics. In parallel, awareness campaigns targeted toward the medical community emphasizing the importance of the ethics as an aspect of clinical research should be established. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

29. Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel.

Author

Reichhart, Nadine, Schöberl, Simon, Keckeis, Susanne, Alfaar, Ahmad S., Roubeix, Christophe, Cordes, Magdalena, Crespo-Garcia, Sergio, Haeckel, Akvile, Kociok, Norbert, Föckler, Renate, Fels, Gabriele, Mataruga, Anja, Rauh, Robert, Milenkovic, Vladimir M., Zühlke, Kerstin, Klussmann, Enno, Schellenberger, Eyk, and Strauß, Olaf

Abstract

Changes in cell function occur by specific patterns of intracellular Ca2+, activating Ca2+-sensitive proteins. The anoctamin (TMEM16) protein family has Ca2+-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca2+-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so far unknown Ano4 function as Ca2+-dependent, non-selective monovalent cation channel; heterologous Ano4 expression in HEK293 cells elicits Ca2+ activated conductance with weak selectivity of K+ > Na+ > Li+. Endogenously expressed Ca2+-dependent cation channels in the retinal pigment epithelium were identified as Ano4 by KO mouse-derived primary RPE cells and siRNA against Ano4. Exchanging a negatively charged amino acid in the putative pore region (AA702-855) into a positive one (E775K) turns Ano4-elicited currents into Cl− currents evidencing its importance for ion selectivity. The molecular identification of Ano4 as a Ca2+-activated cation channel advances the understanding of its role in Ca2+ signaling. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

30. Trends in prevalence of blindness and distance and nearvision impairment over 30 years: an analysis for the GlobalBurden of Disease Study

Author

Bourne, Rupert, Steinmetz, Jaimie, Flaxman, Seth, Briant, Paul Svitil, Taylor, Hugh, Resnikoff, Serge, Casson, Robert James, Abdoli, Amir, Abu-Gharbieh, Eman, Afshin, Ashkan, Ahmadieh, Hamid, Akalu, Yonas, Alamneh, Alehegn Aderaw, Alemayehu, Wondu, Alfaar, Ahmed Samir, Alipour, Vahid, Anbesu, Etsay Woldu, Androudi, Sofia, Arabloo, Jalal, Arditi, Aries, Asaad, Malke, Bagli, Eleni, Baig, Atif Amin, Bärnighausen, Till Winfried, Battaglia Parodi, Maurizio, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Mukharram, Bottone, Michele, Braithwaite, Tasanee, Bron, Alain, Butt, Zahid, Cheng, Ching-Yu, Chu, Dinh-Toi, Cicinelli, Maria Vittoria, Coelho, João, Dagnew, Baye, Dai, Xiaochen, Dana, Reza, Dandona, Lalit, Dandona, Rakhi, Del Monte, Monte, Deva, Jenny, Diaz, Daniel, Djalalinia, Shirin, Dreer, Laura, Ehrlich, Joshua, Ellwein, Leon, Emamian, Mohammad Hassan, Fernandes, Arthur, Fischer, Florian, Friedman, David, Furtado, João, Gaidhane, Abhay Motiramji, Gaidhane, Shilpa, Gazzard, Gus, Gebremichael, Berhe, George, Ronnie, Ghashghaee, Ahmad, Golechha, Mahaveer, Hamidi, Samer, Hammond, Billy Randall, Hartnett, Mary Elizabeth R, Hartono, Risky Kusuma, Hay, Simon, Heidari, Golnaz, Ho, Hung Chak, Hoang, Chi Linh, Househ, Mowafa, Ibitoye, Segun Emmanuel, Ilic, Irena, Ilic, Milena, Ingram, April, Irvani, Seyed Sina Naghibi, Jha, Ravi Prakash, Kahloun, Rim, Kandel, Himal, Kasa, Ayele Semachew, Kempen, John, Keramati, Maryam, Khairallah, Moncef, Khan, Ejaz Ahmad, Khanna, Rohit, Khatib, Mahalaqua Nazli, Kim, Judy, Kim, Yun Jin, Kisa, Sezer, Kisa, Adnan, Koyanagi, Ai, Kurmi, Om, Lansingh, Van Charles, Leasher, Janet, Leveziel, Nicolas, Limburg, Hans, Majdan, Marek, Manafi, Navid, Mansouri, Kaweh, McAlinden, Colm, Mohammadi, Seyed Farzad, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mokdad, Ali, Moosavi, Delaram, Morse, Alan, Naderi, Mehdi, Naidoo, Kovin, Nangia, Vinay, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Ogundimu, Kolawole, Olagunju, Andrew, Ostroff, Samuel, Panda-Jonas, Songhomitra, Pesudovs, Konrad, Peto, Tunde, Quazi Syed, Zahiruddin, Rahman, Mohammad Hifz Ur, Ramulu, Pradeep, Rawaf, Salman, Rawaf, David Laith, Reinig, Nickolas, Robin, Alan, Rossetti, Luca, Safi, Sare, Sahebkar, Amirhossein, Samy, Abdallah, Saxena, Deepak, Serle, Janet, Shaikh, Masood Ali, Shen, Tueng, Shibuya, Kenji, Shin, Jae Il, Silva, Juan Carlos, Silvester, Alexander, Singh, Jasvinder, Singhal, Deepika, Sitorus, Rita, Skiadaresi, Eirini, Skirbekk, Vegard, Soheili, Amin, Sousa, Raúl, Spurlock, Emma Elizabeth, Stambolian, Dwight, Taddele, Biruk Wogayehu, Tadesse, Eyayou Girma, Tahhan, Nina, Tareque, Md Ismail, Topouzis, Fotis, Tran, Bach Xuan, Travillian, Ravensara, Tsilimbaris, Miltiadis, Varma, Rohit, Virgili, Gianni, Wang, Ya Xing, Wang, Ningli, West, Sheila, Wong, Tien, Zaidi, Zoubida, Zewdie, Kaleab Alemayehu, Jonas, Jost, Vos, Theo, Holden, Funding, Anglia Ruskin University (ARU), University of Washington [Seattle], Imperial College London, University of Melbourne, School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia, University of Adelaide, Jahrom University of Medical Sciences, University of Sharjah (UoS), Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University, University of Gondar, Debre Markos University, The Fred Hollows Foundation, University of Leipzig Medical Center, Iran University of Medical Sciences, Samara University, University of Thessaly [Volos] (UTH), Visibility Metrics LLC, University of Texas, University Hospital of Ioannina, Sultan Zainal Abidin University, Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Charles University [Prague] (CU), Government Medical College Pali, All India Institute of Medical Sciences [New Delhi], National Institute of Biomedical Genomics, Babol University of Medical Sciences, Ufa Eye Research Institute, London School of Hygiene and Tropical Medicine (LSHTM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Waterloo [Waterloo], Singapore Eye Research Institute [Singapore] (SERI), Hanoi National University of Education (HNUE), IRCCS San Raffaele Scientific Institute [Milan, Italie], University of Porto - Departamento de Geociências, Ambiente e Ordenamento do Territórioo (UP - DGAOT), Harvard University [Cambridge], University of Michigan [Ann Arbor], University of Michigan System, Universiti Tunku Abdul Rahman (UTAR), National Autonomous University of Mexico (UNAM), Ministry of Health and Medical Education [Iran] (MOHME), University of Alabama at Birmingham [ Birmingham] (UAB), National Institutes of Health [Bethesda] (NIH), Shahroud University of Medical Sciences, Federal University of Sao Paulo (Unifesp), University of Applied Sciences Ravensburg-Weingarten, University of São Paulo (USP), Datta Meghe Institute of Medical Sciences, University College of London [London] (UCL), Haramaya University (HU), Sankara Nethralaya Medical Research Foundation, Indian Institute of Public Health Gandhinagar, Hamdan Bin Mohammed Smart University, University of Georgia [USA], University of Utah, Institution of Public Health Sciences, Independent Consultant, The Chinese University of Hong Kong [Hong Kong], Hamad Bin Khalifa University (HBKU), University of Ibadan, University of Belgrade [Belgrade], Faculty of Science of the University of Kragujevac, University of Kragujevac, Banaras Hindu University [Varanasi] (BHU), Ophtalmologistes Associe Monastir, The University of Sydney, Bahir Dar University (BDU), Harvard University, Mashhad University of Medical Sciences, Fattouma Bourguiba University Hospital, Health Services Academy, L V Prasad Eye Institute, Medical College of Wisconsin [Milwaukee] (MCW), Xiamen University, Oslo Metropolitan University (OsloMet), Kristiania University College = Høyskolen Kristiania, San Juan de Dios Sanitary Park, McMaster University [Hamilton, Ontario], HelpMeSee, Nova Southeastern University (NSU), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Health Information Services, Trnava University, University of Manitoba [Winnipeg], Glaucoma Research Center, Singleton Hospital, Tehran University of Medical Sciences (TUMS), Shahrekord University of Medical Sciences, Institute for Health Metrics and Evaluation [University of Washington], Iran University of Medical Sciences [Tehran, Iran] (IUMS), Lighthouse Guild, Kermanshah University of Medical Sciences, University of KwaZulu-Natal (UKZN), Suraj Eye Institute, Duy Tan University, Sightsavers, Heidelberg University Hospital [Heidelberg], University of New South Wales [Sydney] (UNSW), Queen's University [Belfast] (QUB), Maharishi Markandeshwar University [Mullana] (MM(DU)), Johns Hopkins University (JHU), Public Health England [London], Brien Holden Vision Institute, Fondation Thea, Fred Hollows Foundation, Bill & Melinda Gates Foundation, Lions Clubs International Foundation, Sightsavers International, and University of Heidelberg., Bourne, R. R. A., Steinmetz, J. D., Flaxman, S., Briant, P. S., Taylor, H. R., Resnikoff, S., Casson, R. J., Abdoli, A., Abu-Gharbieh, E., Afshin, A., Ahmadieh, H., Akalu, Y., Alamneh, A. A., Alemayehu, W., Alfaar, A. S., Alipour, V., Anbesu, E. W., Androudi, S., Arabloo, J., Arditi, A., Asaad, M., Bagli, E., Baig, A. A., Barnighausen, T. W., Battaglia Parodi, M., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bijani, A., Bikbov, M., Bottone, M., Braithwaite, T., Bron, A. M., Butt, Z. A., Cheng, C. -Y., Chu, D. -T., Cicinelli, M. V., Coelho, J. M., Dagnew, B., Dai, X., Dana, R., Dandona, L., Dandona, R., Del Monte, M. A., Deva, J. P., Diaz, D., Djalalinia, S., Dreer, L. E., Ehrlich, J. R., Ellwein, L. B., Emamian, M. H., Fernandes, A. G., Fischer, F., Friedman, D. S., Furtado, J. M., Gaidhane, A. M., Gaidhane, S., Gazzard, G., Gebremichael, B., George, R., Ghashghaee, A., Golechha, M., Hamidi, S., Hammond, B. R., Hartnett, M. E. R., Hartono, R. K., Hay, S. I., Heidari, G., Ho, H. C., Hoang, C. L., Househ, M., Ibitoye, S. E., Ilic, I. M., Ilic, M. D., Ingram, A. D., Irvani, S. S. N., Jha, R. P., Kahloun, R., Kandel, H., Kasa, A. S., Kempen, J. H., Keramati, M., Khairallah, M., Khan, E. A., Khanna, R. C., Khatib, M. N., Kim, J. E., Kim, Y. J., Kisa, A., Kisa, S., Koyanagi, A., Kurmi, O. P., Lansingh, V. C., Leasher, J. L., Leveziel, N., Limburg, H., Majdan, M., Manafi, N., Mansouri, K., Mcalinden, C., Mohammadi, S. F., Mohammadian-Hafshejani, A., Mohammadpourhodki, R., Mokdad, A. H., Moosavi, D., Morse, A. R., Naderi, M., Naidoo, K. S., Nangia, V., Nguyen, C. T., Nguyen, H. L. T., Ogundimu, K., Olagunju, A. T., Ostroff, S. M., Panda-Jones, S., Pesudovs, K., Peto, T., Syed, Z. Q., Ur Rahman, M. H., Ramulu, P. Y., Rawaf, D. L., Rawaf, S., Reinig, N., Robin, A. L., Rossetti, L., Safi, S., Sahebkar, A., Samy, A. M., Saxena, D., Serle, J. B., Shaikh, M. A., Shen, T. T., Shibuya, K., Shin, J. I., Silva, J. C., Silvester, A., Singh, J. A., Singhal, D., Sitorus, R. S., Skiadaresi, E., Skirbekk, V., Soheili, A., Sousa, R. A. R. C., Spurlock, E. E., Stambolian, D., Taddele, B. W., Tadesse, E. G., Tahhan, N., Tareque, Md. I., Topouzis, F., Tran, B. X., Travillian, R. S., Tsilimbaris, M. K., Varma, R., Virgili, G., Wang, N., Wang, Y. X., West, S. K., Wong, T. Y., Zaidi, Z., Zewdie, K. A., Jonas, J. B., and Vos, T.

Subjects
Visual acuity, genetic structures, 030231 tropical medicine, Population, Visual impairment, Glaucoma, Blindness, 03 medical and health sciences, 0302 clinical medicine, medicine, Global health, 030212 general & internal medicine, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, education, Eye diseases, Medicine(all), Near vision impairments, education.field_of_study, business.industry, General Medicine, Presbyopia, Systematic reviews, Macular degeneration, medicine.disease, eye diseases, 3. Good health, medicine.symptom, business, Demography
Abstract

Background: To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision loss burden, presenting estimates for 2020, temporal change over three decades between 1990–2020, and forecasts for 2050. Methods: We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. Only studies with samples representative of the population and with clearly defined visual acuity testing protocols were included. We fitted hierarchical models to estimate 2020 prevalence (with 95% uncertainty intervals [UIs]) of mild vision impairment (presenting visual acuity ≥6/18 and

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results