19 results on '"Alexis Luna Aufroy"'
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2. Mayor incidencia de reflujo gastro-esofágico tras gastrectomía vertical
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Alexis Luna Aufroy, Sandra Montmany Vioque, Montse Adell Trape, Assumpta Caixàs Padrós, Valentí Puig Diví, and Pere Rebasa Cladera
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- 2023
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3. Consequencies of therapeutic decision-making based on FAST results in trauma patients with pelvic fracture
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Salvador Navarro Soto, Andrea Campos Serra, Pere Rebasa Cladera, Sandra Montmany Vioque, Alexis Luna Aufroy, and Raquel Gràcia Roman
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Engineering ,Abdominal Injuries ,Therapeutic decision making ,030230 surgery ,Wounds, Nonpenetrating ,medicine.disease ,Pelvis ,Surgery ,Fractures, Bone ,03 medical and health sciences ,0302 clinical medicine ,Laparotomy ,medicine ,Pelvic fracture ,Humans ,In patient ,False positive rate ,Pelvic Bones ,business ,Cause of death - Abstract
FAST is essential to decide whether trauma patients need laparotomy, but it has a notable decrease in accuracy in patients with pelvic fracture. Our objective is to analyze the consequences of therapeutic decision-making based on the FAST results in trauma patients with pelvic fracture.Descriptive study that includes trauma patients older than 16 with a pelvic fracture admitted to the critical care area or who died. The FAST result was compared with a true positive or negative value according to the results of laparotomy or abdominal CT. We recorded diagnosis and treatment of each injury and resolution of the case, detailing the cause of death, among all variables.Over the 13-year period, we included 263 trauma patients with pelvic fracture, with a mean ISS of 31 and mortality of 19%. FAST had a sensitivity of 65.2%, specificity of 69%, false negative rate of 34.8% and false positive rate of 30.9%. Hemodynamically unstable patients died twice as many stable patients (27% vs 14%, P .05). Patients with positive FAST died more than negative FAST (43% vs 26%); and 4 out of 10 hemodynamically unstable patients who underwent non-therapeutic laparotomy after presenting a false positive FAST died from hypovolemic shock. The mortality rate fell from 60% to 20% when preperitoneal packing was performed before angio-embolization of the pelvis.FAST has low accuracy in polytraumatized patients with pelvic fracture. Patients with false positive FAST have higher mortality, which can be reduced notably by applying preperitoneal packing.
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- 2021
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4. Consecuencias de la toma de decisiones terapéuticas con base en el resultado del FAST en pacientes politraumáticos con fractura pélvica
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Salvador Navarro Soto, Pere Rebasa Cladera, Raquel Gràcia Roman, Alexis Luna Aufroy, Sandra Montmany Vioque, and Andrea Campos Serra
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Falsos positivos ,business.industry ,Pelvic fracture ,medicine ,Surgery ,In patient ,030230 surgery ,medicine.disease ,business - Abstract
espanolIntroduccion La exactitud del FAST disminuye notablemente en los pacientes politraumaticos con fractura pelvica. El objetivo es analizar las consecuencias de tomar decisiones terapeuticas basadas en el resultado del FAST en los pacientes politraumaticos con fractura de pelvis. Metodos Estudio descriptivo de pacientes con politraumatismos mayores de 16 anos que han ingresado en el area de criticos o que han fallecido previamente, con fractura pelvica. El resultado del FAST ha sido comparado con un valor realmente positivo o negativo segun el resultado de la laparotomia o de la tomografia computarizada. Resultados En 13 anos, se ha incluido a 263 pacientes politraumaticos con fractura pelvica (ISS medio de 31; mortalidad 19%). El FAST tenia una sensibilidad del 65,2%, una especificidad del 69%, una tasa de falsos negativos del 34,8% y una tasa de falsos positivos del 30,9%. Los pacientes hemodinamicamente inestables tenian el doble de mortalidad que los pacientes estables (27% vs. 14%, p Conclusiones La reducida eficacia del FAST en pacientes con fractura de pelvis nos obliga a cuestionarnos las consecuencias de la toma de decisiones terapeuticas con base en sus resultados. Los pacientes con FAST falsamente positivo tienen una mortalidad mayor, que se puede reducir aplicando un packing preperitoneal. EnglishIntroduction FAST is essential to decide if trauma patients need laparotomy, but has a notably decrease in accuracy in patients with pelvic fracture. Our objective is to analyze the consequences of therapeutic decision-making based on the FAST results in trauma patients with pelvic fracture. Methods Descriptive study that includes trauma patients older than 16 with a pelvic fracture admitted to the critical care area or who were fallecimiento. FAST result was compared with a true positive or negative value according to the results of laparotomy or abdominal CT. We recorded diagnosis and treatment of each injury and resolution of the case, detailing the cause of death, among all variables. Results Over the 13–year period, we included 263 trauma patients with pelvic fracture, with a mean ISS of 31 and mortality of 19%. FAST had a sensitivity of 65.2%, specificity of 69%, false negative rate of 34.8% and false positive rate of 30.9%. Hemodynamically unstable patients died twice as many stable patients (27% vs. 14%, p Conclusion FAST has low accuracy in polytraumatized patients with pelvic fracture. Patients with false positive FAST have higher mortality, which can be reduce notably applying a preperitoneal packing.
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- 2021
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5. Eficacia del abordaje manual fisioterapéutico y osteópatico de la enfermedad por reflujo gastroesofágico y hernia de hiato tipo I
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Ricard Tutusaus Homs, Alexis Luna Aufroy, Josep Maria Potau Ginés, and Salvador Navarro Soto
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- 2022
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6. Pruebas diagnósticas empleadas en la estadificación preoperatoria del cáncer de la unión esofagogástrica: rendimiento y recomendaciones basadas en la evidencia
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Salvador Navarro Soto and Alexis Luna Aufroy
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,Medicine ,Surgery ,030230 surgery ,business ,Humanities - Abstract
Resumen La estadificacion clinica preoperatoria es critica para seleccionar aquellos pacientes cuya enfermedad esta localizada y se podra beneficiar de una cirugia con intencion curativa. Idealmente, dicha estadificacion deberia predecir la invasion tumoral, la afectacion linfatica y las metastasis a distancia. Con el cTNM podemos seleccionar aquellos pacientes a los que podremos ofrecer una reseccion endoscopica, una cirugia radical o evitarla en aquellos con metastasis a distancia. Para el diagnostico inicial de los adenocarcinomas de la union esofagogastrica se requiere una endoscopia con biopsias. Para la estadificacion clinica: TC toracoabdominopelvico, ultrasonografia endoscopica y la PET o la PET-TC. Otras exploraciones de utilidad son: transito baritado, reseccion endoscopica de la mucosa o diseccion endoscopica de la submucosa (para valoracion de estadios iniciales) y la laparoscopia de estadificacion. Una vez establecida la resecabilidad del tumor debera valorarse la operabilidad del mismo en funcion del estado del paciente.
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- 2019
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7. Diagnostic tests for preoperative staging of esophagogastric junction tumors: performance and evidence-based recomendations
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Alexis Luna Aufroy and Salvador Navarro Soto
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Endoscopic ultrasound ,medicine.medical_specialty ,Evidence-based practice ,Esophageal Neoplasms ,Biopsy ,Contrast Media ,Endoscopic mucosal resection ,Adenocarcinoma ,Endosonography ,Preoperative staging ,Positron Emission Tomography Computed Tomography ,Preoperative Care ,medicine ,Humans ,Endoscopy, Digestive System ,Radical surgery ,Esophagogastric junction ,Neoplasm Staging ,medicine.diagnostic_test ,business.industry ,General Engineering ,Diagnostic test ,Endoscopy ,Positron-Emission Tomography ,Laparoscopy ,Radiology ,Esophagogastric Junction ,business ,Tomography, X-Ray Computed ,Barium Enema - Abstract
Preoperative clinical staging is critical to select those patients whose disease is localized and may benefit from surgery with curative intent. Ideally, such staging should predict tumor invasion, lymphatic involvement and distant metastases. With the cTNM, we are able to select patients who could benefit from endoscopic resection, radical surgery or less radical treatment in patients with distant metastasis. The initial diagnosis of adenocarcinomas of the esophagogastric junction requires endoscopy with biopsies. For clinical staging, thoracoabdominal-pelvic CT scan, endoscopic ultrasound and PET or PET/CT are used. Other useful explorations are: barium swallow, endoscopic mucosal resection or endoscopic submucosal dissection (for assessment in initial stages) and staging laparoscopy. Once the resectability of the tumor has been established, the operability of the tumor should be assessed according to the patient's condition.
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- 2019
8. Libro informático del residente de cirugía: Un paso adelante
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Alexis Luna Aufroy, Salvador Navarro Soto, Laura Mora López, Xavier Serra Aracil, Pere Rebasa Cladera, Sheila Serra Pla, Carlos Javier Gómez Díaz, and Cristina Jurado Ruiz
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business.industry ,Medicine ,Surgery ,business ,Humanities - Abstract
Resumen Introduccion El libro informatico del residente quirurgico (LIRQ) tiene por objetivos: simplificar el registro de la actividad formativa de los residentes quirurgicos y permitir obtener informes fiables y detallados sobre la misma, para su evaluacion. Metodos El LIRQ es una base de datos unica y compartida. Los residentes registran de manera prospectiva sus actividades, en 3 bloques: quirurgico, cientifico y docente. Permite acceder a informes de la actividad registrada, actualizados al momento. Resultados Periodo de estudio, usando el LIRQ: Entre junio de 2011 y mayo de 2013. Se registraron un total de 4.255 cirugias y 11.907 procedimientos quirurgicos. Por otro lado, cada residente registro 250 cirugias por ano y 700 procedimientos quirurgicos por ano. La actividad quirurgica como cirujano principal que se desarrolla el primer ano de residencia es, principalmente, en cirugia urgente (68,01%) y por via laparotomica (97,73%), mientras que durante el quinto ano de residencia se desarrolla un 51,27% en cirugia programada y se utiliza la via laparoscopica en un 23,10% de los casos. Durante este periodo, los residentes participaron en un total de 11 publicaciones cientificas, 75 presentaciones en congresos y 69 actividades de formacion continuada. Conclusiones El LIRQ es una herramienta util que simplifica el registro y analisis de los datos sobre la actividad quirurgica y cientifica de los residentes. Constituye un paso adelante en la evaluacion de la formacion de los residentes quirurgicos, sin embargo, es solo un paso intermedio en el camino del desarrollo de un registro espanol de mayor envergadura.
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- 2015
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9. Acute Mesenteric Ischemia: Utility of Endovascular Techniques
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Alexis Luna Aufroy, Gabriel Cánovas Moreno, José Manuel Hidalgo Rosas, Salvador Navarro Soto, Joan Falcó Fages, José Ramón Fortuño Andres, and Anna Serracant Barrera
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medicine.medical_specialty ,Palliative treatment ,business.industry ,medicine.medical_treatment ,Endovascular Procedures ,Conventional surgery ,General Engineering ,Retrospective cohort study ,Bowel resection ,medicine.disease_cause ,Revascularization ,Surgery ,Acute mesenteric ischemia ,Ischemia ,Mesenteric Ischemia ,medicine ,Humans ,Leukocytosis ,Irritation ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Retrospective Studies - Abstract
Introduction Acute mesenteric ischemia (AMI) has a high mortality. Early diagnosis and treatment are very important. In our institution there is a therapeutic protocol that includes endovascular techniques (ET) in patients with AMI without peritoneal irritation at diagnosis. The aim of this study was to evaluate the use of ET in conjunction with conventional surgery in the management of potentially reversible IMA diagnosed by computed tomography (CT-angiography). Methods Observational, descriptive and retrospective study that evaluated the use of ET in patients with AMI (arterial origin) in two periods (before and after the application of a protocol that includes ET), between 2009 and 2013. All patients were diagnosed by a CT-angiography, as the diagnostic technique of choice, because of the clinical and analytical suspicion. Results Our series included 73 patients with IMA diagnosed by CT-angiography (45: 2009–2011; 28: 2012–2013). Leukocytosis was common (82%), high lactate levels are less frequent (47% vs 53%). There were 49 patients with IMA without peritoneal irritation. In 51% bowel resection surgery was performed (44% survival); 18%: revascularization by ET (survival 67%); 31%: palliative treatment (0% survival). 33% of patients undergoing first-line RVI needed a surgical rescue (bowel resection). The overall mortality was 67% (2009–2011) vs 62% (2012–2013). Conclusions Since the protocol application, there is a higher indication of ET in patients with AMI without peritoneal irritation, showing a decreased mortality. With ET application, there is a higher survival in these patients. In our experience, the use of ET in cases of AMI without peritoneal irritation at diagnosis, may increase survival.
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- 2015
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10. Isquemia mesentérica aguda: utilidad de las técnicas de revascularización endovascular
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Salvador Navarro Soto, Gabriel Cánovas Moreno, José Manuel Hidalgo Rosas, Anna Serracant Barrera, Joan Falcó Fages, José Ramón Fortuño Andres, and Alexis Luna Aufroy
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,business - Abstract
Resumen Introduccion La isquemia mesenterica aguda (IMA) presenta una elevada mortalidad. El diagnostico y el tratamiento precoces son claves. En nuestro centro aplicamos un protocolo terapeutico que incluye la radiologia vascular intervencionista (RVI) en pacientes con IMA sin irritacion peritoneal. El objetivo de este estudio fue evaluar el uso de la RVI conjuntamente con la cirugia convencional en el manejo de la IMA de intestino delgado potencialmente reversible diagnosticada mediante tomografia computarizada vascular (angio-TC). Metodos Estudio observacional, retrospectivo y descriptivo, donde se valora el manejo diagnostico y terapeutico de la IMA en 2 periodos (antes y despues de la aplicacion de un protocolo que incluye la RVI) entre 2009 y 2013. El diagnostico de eleccion es mediante angio-TC, ante la sospecha clinico-analitica. Resultados Nuestra serie incluye a 73 pacientes diagnosticados de IMA mediante angio-TC (45: 2009-2011; 28: 2012-2013). La leucocitosis es frecuente (82%), siendo menos frecuente la lactacidemia (47% vs. 53%). Hay 49 pacientes con IMA y exploracion abdominal normal. En el 51% se realizo cirugia de reseccion intestinal (supervivencia 44%); 18%: revascularizacion mediante RVI (supervivencia 67%); 31%: tratamiento paliativo (supervivencia 0%). El 33% de los pacientes sometidos a RVI como primera linea precisaron de cirugia de rescate (reseccion intestinal). La mortalidad global es del 67% (2009-2011) vs. 62% (2012-2013). Conclusiones Desde la aplicacion del protocolo ha aumentado la indicacion de RVI para tratar a pacientes sin irritacion peritoneal, objetivando una disminucion de la mortalidad global. En nuestra experiencia, la aplicacion de RVI en casos de IMA sin irritacion peritoneal al diagnostico puede incrementar la supervivencia.
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- 2015
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11. Validación de un modelo de riesgo de evisceración
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Sandra Montmany Vioque, José Rosas, Constanza Corredera Cantarín, Pere Rebasa Cladera, Alexis Luna Aufroy, Salvador Navarro Soto, and Carlos Javier Gómez Díaz
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business.industry ,Medicine ,Surgery ,business ,Humanities - Abstract
Aquest treball preten valorar la utilitat del model de risc d'evisceracio desenvolupat per Van Ramshorst et al. entre els pacients sotmesos a cirurgia abdominal per laparotomia mitja en el Servei de Cirurgia General i de l'Aparell Digestiu de l'Hospital de Sabadell – Corporacio Sanitaria i Universitaria Parc Tauli – Barcelona. El model de risc inclou dades postoperatories que fan perdre capacitat pronostica clinica, per aquest motiu es proposa una modificacio d'aquest model (Van Ramshorst modificat), tenint en compte nomes les variables preoperatories. Podem concloure que mentre el model de risc d'evisceracio de Van Ramshorst et al. es util en la nostra mostra de pacients, la modificacio proposada necessitaria retocs per a millorar la seva capacitat pronostica.
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- 2014
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12. Validation of Abdominal Wound Dehiscence's Risk Model
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José Rosas, Salvador Navarro Soto, Sandra Montmany Vioque, Constanza Corredera Cantarín, Pere Rebasa Cladera, Alexis Luna Aufroy, and Carlos Javier Gómez Díaz
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Adult ,Male ,medicine.medical_specialty ,Preoperative risk ,Dehiscence ,Risk Assessment ,Risk model ,Abdomen ,Surgical Wound Dehiscence ,medicine ,Humans ,In patient ,Longitudinal Studies ,Aged ,Retrospective Studies ,Laparotomy ,Models, Statistical ,business.industry ,Digestive surgery ,General Engineering ,Retrospective cohort study ,Midline laparotomy ,Middle Aged ,Abdominal wound ,Surgery ,Female ,business - Abstract
The aim of this study is to determine the usefulness of the risk model developed by van Ramshorst et al., and a modification of the same, to predict the abdominal wound dehiscence's risk in patients who underwent midline laparotomy incisions.Observational longitudinal retrospective study.Patients who underwent midline laparotomy incisions in the General and Digestive Surgery Department of the Sabadell's Hospital-Parc Taulí's Health and University Corporation-Barcelona, between January 1, 2010 and June 30, 2010. Dependent variable: Abdominal wound dehiscence.Global risk score, preoperative risk score (postoperative variables were excluded), global and preoperative probabilities of developing abdominal wound dehiscence.176 patients. Patients with abdominal wound dehiscence: 15 (8.5%). The global risk score of abdominal wound dehiscence group (mean: 4.97; IC 95%: 4.15-5.79) was better than the global risk score of No abdominal wound dehiscence group (mean: 3.41; IC 95%: 3.20-3.62). This difference is statistically significant (P.001). The preoperative risk score of abdominal wound dehiscence group (mean: 3.27; IC 95%: 2.69-3.84) was better than the preoperative risk score of No abdominal wound dehiscence group (mean: 2.77; IC 95%: 2.64-2.89), also a statistically significant difference (P.05). The global risk score (area under the ROC curve: 0.79) has better accuracy than the preoperative risk score (area under the ROC curve: 0.64).The risk model developed by van Ramshorst et al. to predict the abdominal wound dehiscence's risk in the preoperative phase has a limited usefulness. Additional refinements in the preoperative risk score are needed to improve its accuracy.
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- 2014
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13. Deciduosis apendicular como causa de abdomen agudo
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Alexis Luna Aufroy, Ruth Orellana Fernández, Mariona Novell Grau, Joan Carles Ferreres Piñas, and Salvador Navarro Soto
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,0302 clinical medicine ,business.industry ,medicine ,Surgery ,030230 surgery ,business - Published
- 2018
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14. Appendicular Deciduosis as a Cause of Acute Abdomen
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Mariona Novell Grau, Alexis Luna Aufroy, Salvador Navarro Soto, Joan Carles Ferreres Piñas, and Ruth Orellana Fernández
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Gynecology ,medicine.medical_specialty ,Pregnancy ,business.industry ,030231 tropical medicine ,Decidua ,General Engineering ,Cecal Diseases ,medicine.disease ,Appendix ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Acute abdomen ,Medicine ,030212 general & internal medicine ,medicine.symptom ,business - Published
- 2018
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15. Surgical electronic logbook: A step forward
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Alexis Luna Aufroy, Carlos Javier Gómez Díaz, Cristina Jurado Ruiz, Sheila Serra Pla, Laura Mora López, Salvador Navarro Soto, Pere Rebasa Cladera, and Xavier Serra Aracil
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,medicine.medical_treatment ,Electrical Equipment and Supplies ,education ,General Engineering ,Continuing education ,Internship and Residency ,Surgical procedures ,Surgery ,Emergency surgery ,Shared database ,Laparotomy ,Medicine ,Clinical Competence ,Elective surgery ,business ,Laparoscopy ,Logbook - Abstract
Introduction The surgical electronic logbook (surgical e-logbook) aims to: simplify registration of the training activities of surgical residents, and to obtain reliable and detailed reports about these activities for resident evaluation. Methods: The surgical e-logbook is a unique and shared database. Residents prospectively record their activities in 3 areas: surgical, scientific and teaching. We can access activity reports that are constantly updated. Results Study period using the surgical e-logbook: Between June 2011 and May 2013. Number of surgeries reported: 4255. Number of surgical procedures reported: 11,907. Number of surgeries per resident per year reported: 250. Number of surgical procedures per resident per year reported: 700. Surgical activity as a primary surgeon during the first year of residency is primarily in emergency surgery (68.01%) and by laparotomy (97.73%), while during the fifth year of residency 51.27% is performed in elective surgery and laparoscopy is used in 23.10% of cases. During this period, residents participated in a total of 11 scientific publications, 75 conference presentations and 69 continuing education activities. Conclusions The surgical e-logbook is a useful tool that simplifies the recording and analysis of data about surgical and scientific activities of the residents. It is a step forward in the evaluation of the training of surgical residents, however, is only an intermediate step towards the development of a larger Spanish registry.
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- 2014
16. [Measurement of lactic acid in multiple injury patients and its usefulness as a predictor of multiorgan failure and mortality]
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Sandra, Montmany Vioque, Salvador, Navarro Soto, Pere, Rebasa Cladera, Alexis, Luna Aufroy, Carlos, Gómez Díaz, and Heura, Llaquet Bayo
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Adult ,Multiple Trauma ,Predictive Value of Tests ,Multiple Organ Failure ,Humans ,Lactic Acid ,Middle Aged - Abstract
The use of lactic acid as marker of occult hyperfusion and its relationship with multiorgan failure (MOF) and/or mortality is a subject of debate.A prospective study was conducted on multiple injury patients over 16 years of age in critical care areas. The lactic acid was measured at the beginning and at 24 hours of the trauma and associating it with the patient morbidity and mortality.A total of 342 patients, with a mean injury severity score of 24.1, were included. The patients who survived had an initial, and 24 hours after the trauma, lactic acid of 27.8 mg/dl and 17.9 mg/dl, respectively, (normal values less than 22 mg/dl), increasing to 36.5mg/dl and 40.2mg/dl, respectively, in those who died. There were no differences between the initial lactic acid in patients with and without MOF, being increased at 24 hours in those who had MOF (17.8 vs 26.7). The patients with a lactic acid that got worse or remained abnormal at 24 hours had a higher mortality than those in which it remained the same or improved (25% - 17.1% vs 6.3% - 0.8%), with the percentage of patients with MOF also increasing (40.6% - 32.8% vs 14.9% - 11.1%). In haemodynamically stable patients, there was also a higher mortality when the lactic acid got worse or remained abnormal in the first 24 hours (23.8% - 19.2% vs 8.8% - 0%), as well as a higher percentage of MOF (38.1% - 26.9% vs 10.9% - 7.6%).The lactic acid results in the first 24 hours of the multiple injury patient are associated with mortality and MOF, even when the patient is haemodynamically stable.
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- 2011
17. [Multiple splenic abscesses]
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Judit, Hermoso Bosch, Neus, García Monforte, Alexis, Luna Aufroy, and Sandra, Montmany Vioque
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Male ,Abdominal Abscess ,Streptococcal Infections ,Humans ,Streptococcus mitis ,Middle Aged ,Splenic Diseases - Published
- 2009
18. Gastrointestinal stromal tumors: experience in 49 patients
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Ruth Orellana Fernández, Salvador Navarro Soto, Alexis Luna Aufroy, Ana Darnell Martín, Pere Rebasa Cladera, Eva Artigau Nieto, Elsa Dalmau Pórtulas, and Carles Pericay Pijaume
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Leiomyosarcoma ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Gastrointestinal Stromal Tumors ,medicine.medical_treatment ,Rectum ,Gastroenterology ,Internal medicine ,medicine ,Humans ,Esophagus ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chemotherapy ,biology ,GiST ,business.industry ,CD117 ,Stomach ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,digestive system diseases ,Leiomyoma ,medicine.anatomical_structure ,Treatment Outcome ,Oncology ,biology.protein ,Female ,business - Abstract
Gastrointestinal stromal tumours (GIST) are mesenchymal tumours of the digestive tract originated in the interstitial cells of Cajal. They express the tyrosine kinase c-kit (CD117) activity receptor. Mutations in this receptor cause neoplastic development. Curative treatment continues to be radical resection of the tumour and is resistant to commonly employed chemotherapy regimens. Imatinib mesilate is a drug that inhibits c-kit activity expressed by GIST and its activity in these tumours has been demonstrated.Retrospective study of all cases of leiomyoma, leiomyosarcoma, schwannoma, and stromal or mesenchymal tumors from 1989 to July 2004. C-kit and CD34 proteins were detected at immunohistochemical study in addition to the usual markers for mesenchymal tumours.49 GISTs were diagnosed, 26 males and 23 females (mean age 64.1). Symptoms were digestive tract bleeding (n = 13), abdominal pain (n = 13), intestinal occlusion (n = 4) and others. The lesion was located in small bowel (n = 22), stomach (n = 19), rectum (n = 3), peritoneum (n = 2), esophagus (n = 1), omentum (n = 1), and retroperitoneum (n = 1). Forty-three of the 49 patients underwent surgery; radical resection was performed in 37 (75.5%) and palliative surgery in the other six (16.2%). Two of the patients that did not undergo surgery received chemotherapy. At the time of study, 28 (57.14%) patients remained alive, 23 (46.9%) of whom were disease- free and five (10.2%) were not. Nineteen (38.7%) patients died.The results of our series are similar to the others published. Before the year 2001, surgery was the only successful option for the GIST. Surgical resection continues being the best treatment to definitively cure this disease. Imatinib is used to treat not only resectable tumours, but even to allow the possibility to make a subsequent rescue surgery. On the other hand, Imatinib is used in the treatment of the metastatic disease.
- Published
- 2006
19. Abscesos esplénicos múltiples
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Neus García Monforte, Sandra Montmany Vioque, Judit Hermoso Bosch, and Alexis Luna Aufroy
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,business - Abstract
pondencia. co: jhermoso@tauli.cat (J. Hermoso Bosch) Varon de 59 anos con antecedente de exodoncia hace un mes sin complicaciones. Presenta fiebre, astenia y dolor abdominal, se lo trata con analgesia y antibioticos sin mejoria, por lo que ingresa para completar estudio. Se realiza una ecocardiografia transtor acica por sospecha confirmada de endocarditis que muestra fraccion de eyeccion del 40%. En la TC de abdomen (fig. 1) se observan abscesos espl enicos multiples, que se puncionan con cultivo positivo para Streptococcus mitis. Debido a empeoramiento clinico con insuficiencia cardiaca, hipotension e insuficiencia renal se le practica esplenectomia, sin identificacion de germen en pieza quirurgica (fig. 2). Tiene una evolucion torpida por patologia cardiaca, y se le da el alta hospitalaria al mes de la intervencion.
- Published
- 2010
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