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The purpose of this study was analysis of relationships between parameters of metabolic gases transportation system in men or animals and dynamics of gases contents in alveolar and box spaces. The analysis is based on lumped parameter mathematical modeling. The full system of equations and reductions of governing equations are considered. The modeling is used for interpretation of experimental data on O2, CO2 and CO contents in a chamber with a Macaca mulatta monkey.

The purpose of this study was a development of a technique of noninvasive estimation of a biological effect of radiation exposure in monkeys by virtue of a laser measurement of endogenous CO content in exhaled air and technique's testing in the experiment with acute radiation exposure. A control and a test groups consisted of two rhesus monkeys each. The test group was exposed to 6 hours radiation exposure with 1.2 Gy dose produced by gamma-rays. We measured the changes of endogenous CO excretion in animals located in the opened system of the box by virtue of the developed laser based CO-meter. We found that CO excretion increased on the 3rd day after radiation exposure. Consumption of oxygen and excretion of carbon dioxide did not change after the exposure.

E-mail: Stepanovkapella.gpi.mYurii A.Shulagin,Institute of Oceanology of Russian Academy of ScienceMoscow, RussiaAlexander I.D'yachenkoInstitute ofBiomedical Problems, Moscow, RussiaABSTRACTMiddle infrared tunable diode lasers (TDL) were applied to studies of pulmonary excretion of endogenous carbonmonoxide (CO). Variations of the CO content level in exhaled air of healthy nonsmokers were investigated fordifferent environmental conditions with the applied laser technique. Correlation ofthe obtained data with atmosphericCO contamination and elevated oxygen content were studied as well as diurnal variations of the endogenous CO inexhalation was observed. Criteria for correct conditions ofthe endogenous CO detection in breath could be derived onthis basis. Developed laser approach and methods were applied for the analysis ofthe excreted CO level in differentdiseases like bronchial asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease,anemia and hepatitis. Laser based close-to-real-time monitoring ofthe endogenous CO elimination with breath in thecourse of different dynamic tests was demonstrated to be informative in studies of blood oxygen transport and pH