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Diabetes mellitus is a chronic disease characterized by elevated blood sugar levels as a result of impaired insulin metabolism. Uncontrolled type 2 diabetes mellitus can result in significant complications. The purpose of the community service activities is to increase the community's knowledge, awareness, and ability to prevent, detect, and manage diabetes mellitus. This activity requires collaboration between the local community, the community service team, and medical personnel. First, the public is counseled about diabetes mellitus using effective and easy-to-understand communication methods. In addition, individuals who are at a high risk or have prediabetes are identified through early screening procedures. In addition, community service activities include providing assistance and guidance to people with diabetes mellitus. During community service activities, the effectiveness of counseling and early screening was also evaluated and monitored. This activity is anticipated to provide long-term benefits to efforts to prevent and manage diabetes mellitus in the community by utilizing a holistic approach and involving active community participation.

Aims: To find out whether there is a correlation between anxiety and smartphone addiction in the teenager population at kalam kudus II senior high school. Study Design: This research was a cross sectional study Place and Duration of Study: Kalam Kudus II Senior High School Jakarta on December 15 2022 . Methodology: This research was a cross sectional study, the target population in this study were all high school students. The reachable population in this study were all students at Kalam Kudus II Senior High School Jakarta. The sample of this study is part of the reachable population that meets the inclusion criteria.The minimum sample size required is 97 respondents (type I error of 5% with a research power of 95%). Results: This study included 178 respondents who met the inclusion criteria. Based on the results of the Spearman Correlation Test, it was found that there was a positive correlation of 0.274 (Weak) and statistically significant (p-value

Teenagers with inadequate knowledge about cosmetics are more likely to use harmful or unlawful goods. Students at SMA Kalam Kudus II Jakarta have never received instruction on the selection and application of beauty products. This counseling session is anticipated to raise the SMA Kalam Kudus II Jakarta students' awareness of the importance of utilizing adolescent-appropriate and safe skin care products and how to select them. This counseling procedure is conducted offline for counseling participants at Kalam Kudus II Jakarta High School. The given counseling material addresses a variety of adolescent skin conditions, as well as the many types of skincare ingredients and how to choose the appropriate one based on the adolescent's skin. Compared to the Pre-test, which was administered prior to the presenter's explanation of the topic, there was an increase in knowledge on the Post-test. Therefore, it can be inferred that participants gained knowledge from this activity's material and conversations, particularly in regards to the skincare material offered.

Clean and Healthy Living Behavior is an endeavor to live a healthy lifestyle at both the individual and communal levels. In the current pandemic era, it is crucial to focus on Clean and Healthy Living Behavior in order to avoid various viruses and diseases. The necessity of Clean and Healthy Behavior must continue to be emphasized to all segments of society. Youth is a group that need attention. According to a situational analysis conducted at SMA Kalam Kudus II in Jakarta, there is a problem with poor levels of cleanliness and health consciousness. To raise high school students' understanding of clean and healthy lives, it is required to conduct activities such as lectures, discussions, and outreach. This service activity takes place in Kalam Kudus II Jakarta High School. This service action was accomplished by performing a survey of service sites, preparing service locations, and delivering Clean and Healthy Behavior support resources. Youth members have participated in Clean and Healthy Living Behavior socialization activities using lecture, discussion, and question and answer formats. This service activity worked smoothly overall. The conclusion that can be derived from this is that service activity participants recognize the significance of clean and healthy lifestyle choices in preventing various diseases.

Jumlah rata-rata minuman manis yang dikonsumsi ialah sekitar 100 liter per orang setiap tahunnya. Pola konsumsi minuman gula berlebih dapat mengakibatkan kejadian obesitas. Studi ini bertujuan untuk melihat bagaimana hubungan pola konsumsi minuman bergula dengan timbulnya obesitas. Studi analitik ini menggunakan desain potong lintang yang dilakukan di Puskesmas Kecamatan X wilayah Jakarta Barat pada bulan Januari hingga Maret 2020. Pengambilan 136 responden dengan teknik consecutive sampling. Data pola konsumsi minuman bergula didapatkan dengan kuesioner sedangkan status gizi dilakukan dengan data pengukuran tinggi badan dan berat badan. Data yang diperoleh dianalisis bivariat dengan uji statistik chi-square dengan batas kemaknaan p

Prevalensi obesitas mengalami peningkatan setiap tahunnya dan diduga berhubungan dengan konsumsi asupan gula dalam minuman bersoda yang berlebihan. Kandungan gula dalam 1 kaleng minuman bersoda 350 mL mencapai 40 hingga 50 gram. Sejauh ini belom ada data yang melihat asupan gula dalam minuman bersoda terhadap obesitas pada kelompok usia reproduktif di Jakarta. Studi ini merupakan studi analitik dengan desain potong lintang yang dilakukan di Puskesmas Kecamatan Jakarta Barat pada bulan Januari hingga Febuari 2020. Pengambilan responden dilakukan dengan teknik consecutive sampling. Jumlah asupan gula didapatkan dengan menggunakan semi-quantitative food frequentcy questionaire (SQ-FFQ) sedangkan status gizi dilakukan dengan data pengukuran tinggi badan dan berat badan. Data yang diperoleh dianalisis dengan uji statistic chi-square dengan batas kemaknaan p

Prevalensi obesitas mengalami peningkatan setiap tahunnya. Kejadian ini diduga karena kurangnya asupan serat dalam buah dan sayur. Diketahui, seseorang yang mengonsumsi sayur minimal 3 kali dan buah minimal 2 kali yang setara dengan 30-37gram/hari dapat menurunkan kejadian obesitas. Studi ini merupakan studi analitik dengan desain potong lintang yang dilakukan di Puskesmas Kecamatan Grogol Petamburan Jakarta Barat pada bulan Januari - Febuari 2020. Sampel studi ini adalah 194 pengunjung Puskesmas berusia 20 - 45 tahun yang diambil menggunakan teknik consecutive sampling. Hasil penelitian memperlihatkan 110 (56,7%) subjek memiliki status gizi lebih hingga obesitas dan sebanyak 163 (84%) subjek mempunyai asupan serat yang kurang. Hasil uji statistik didapatkan hubungan yang bermakna antara asupan serat dalam buah dan sayur dengan obesitas pada usia 20-45 tahun dengan nilai p 0,017 (p

The global pandemic has made most of the activities at home. This condition poses significant health challenges. The increasing number of hours spent sitting, having improper posture, lack of exercise, unhealthy diet and pandemic stress can all lead to the low back pain. Low Back Pain is a multifactorial disease. Therefore, an integrated prevention strategy is needed to prevent Low Back Pain. Based on these problems, the community service activity was held. This activity is carried out to provide education related to knowledge of back pain in good working positions, movements to avoid, and exercises that can overcome complaints of back pain. The target of this activity is to increase public knowledge regarding low back pain, improve individual health degrees, educate healthy lifestyles, pay attention to nutritional intake, be active in sports, reduce the incidence of back pain and improve quality of life so that they can continue to work during the pandemic. This activity was carried out online on 27 May 2021 at 8.00-12.00 and was attended by 44 participants from PKK cadres, Tomang Village, West Jakarta. In addition, pre-test and post-test were also conducted. The average score of the pre-test was 53.63, while the average score of the post-test was 62.27. These results indicate that there is an increase in knowledge of 16.10%. Participants are expected to be able to apply the knowledge related to preventing back pain with exercise, good nutrition and can educate families about habits in preventing back painABSTRAK:Pandemi global telah membuat sebagian besar beraktivitas di rumah. Kondisi ini menimbulkan tantangan kesehatan yang signifikan. Meningkatnya jumlah jam yang dihabiskan untuk duduk, memiliki postur tubuh yang tidak tepat, kurang olah raga, pola makan yang tidak sehat dan stres pandemi dapat menyebabkan nyeri punggung bawah yang berkepanjangan. Low Back Pain merupakan penyakit multifaktor. Oleh karena itu, perlu strategi pencegahan terpadu untuk mencegah Low Back Pain. Berdasarkan permasalahan tersebut, kegiatan penyuluhan terkait nyeri pinggang belakang dan bagaimana mengatasinya diselenggarakan. Kegiatan ini dilakukan untuk memberikan edukasi terkait pengetahuan nyeri pinggang belakang posisi kerja yang baik, gerakan yang dihindari, serta senam yang dapat mengatasi keluhan nyeri pinggang belakang. Target kegiatan ini adalah bertambahnya pengetahuan masyarakat terkait low back pain, meningkatkan derajat kesehatan individu, mengedukasi pola hidup sehat, memperhatikan asupan gizi, giat berolahraga, menurunkan angka kejadian nyeri pinggang belakang serta meningkatkan kualitas hidup agar tetap berkarya selama pandemi. Kegiatan ini dilakukan via daring pada tanggal 27 Mei 2021 pukul 8.00-12.00 dan dihadiri oleh 44 peserta yang berasal dari kader PKK Kelurahan Tomang Jakarta Barat. Selain itu, juga dilakukan pre-test dan post-test. Nilai rata-rata pre-test adalah 53.63, sedangkan nilai rata-rata pos-test adalah 62.27. Hasil tersebut menunjukan bahwa terjadi peningkatan pengetahuan sebesar 16.10%. Para peserta diharapkan dapat menerapkan materi terkait pencegahan nyeri pinggang belakang dengan senam, asupan gizi yang baik dan dapat mengedukasi keluarga tentang kebiasaan dalam mencegah nyeri pinggang belakang

Stunting or short stature is one of the nutritional problems in toddlers in the world, especially in developing countries. The results of Survei Status Gizi Balita Indonesia in 2019 showed the prevalence of stunting in Indonesia reached 27.7% which indicates stunting is still a moderate problems. The impact of stunting can affect the increased rates of morbidity and mortality in toddlers, also the decrease quality of life in adulthood. Various factors can influence stunting related to chronic malnutrition during the first 1,000 days of life covering the fetal period in the womb up to the first two years of life. This period is a rapid growth period and does not occur in the next age group, therefore adequate nutritional intake is very important at this period. Tomang subdistrict which is a partner of FK UNTAR islocated in the West Jakarta area where, the RISKESDAS Report of DKI Jakarta Province 2018, showed that the percentage of very short stature and short stature is 12,87% of toddlers in the West Jakarta area. The first step to reducing and control the prevalence of stunting has been conducted an education about Healthy and Balanced Diet During the First Thousand Days to cadres in the village of Toman, West Jakarta. The activity showed that most cadres experienced increased knowledge about healthy food intake and balanced nutrition after getting based on pre-posttests of education. The achieved results need to be followed up with training and mentoring so that the cadres are always motivated and renew their knowledge related to stunting management. So, they can carry out their duties thus can contribute to reducing the prevalence of stunting in toddlersABSTRAK:Stunting atau pendek merupakan salah satu masalah gizi yang dialami oleh balita di dunia terutama di negara sedang berkembang. Survei Status Gizi Balita Indonesia tahun 2019 menunjukkan prevalensi stunting di Indonesia mencapai 27,7% yang menunjukkan stunting di Indonesia masih merupakan masalah dengan kategori tingkat sedang. Dampak stunting pada balita dapat berakibat meningkatnya angka kesakitan dan kematian pada bayi dan balita, serta menurunnya kualitas hidup di usia dewasa. Berbagai faktor dapat memengaruhi terjadinya stunting terkait kekurangan gizi kronis selama 1.000 hari pertama kehidupan (HPK) anak yang meliputi masa janin dalam kandungan sampai dua tahun setelah kelahiran. Masa HPK merupakan masa proses tumbuh kembang yang sangat cepat dan tidak terjadi pada kelompok usia selanjutnya, oleh karena itu pemenuhan asupan gizi pada masa ini sangat penting. Kelurahan Tomang yang merupakan mitra FK UNTAR terletak di daerah Jakarta Barat dimana berdasarkan Laporan RISKESDAS Provinsi DKI Jakarta 2018, menunjukkan kejadian sangat pendek dan pendek sebesar 12,87% pada usia bawah dua tahun di wilayah Jakarta Barat. Sebagai langkah awal untuk pencegahan dan pengendalian terjadinya stunting, telah dilakukan edukasi mengenai Pola Makan Sehat dan Seimbang Selama HPK kepada para kader di kelurahan Tomang, Jakarta Barat. Kegiatan edukasi tersebut menunjukkan sebagian besar kader mengalami peningkatan pengetahuan tentang asupan makanan sehat dan gizi seimbang setelah mendapat edukasi berdasarkan pre-pos tes. Hasil yang dicapai ini perlu dilakukan tindak lanjut dengan pelatihan dan pendampingan agar para kader selalu termotivasi dan memperbaharui pengetahuan terkait pengendalian stunting dalam menjalankan tugasnya dengan demikian dapat berkontribusi dalam upaya menurunkan angka kejadian stunting pada balita.

The complexity of the nervous system structure and function, and its slow regeneration rate, makes it more difficult to treat compared to other tissues in the human body when an injury occurs. Moreover, the current therapeutic approaches including the use of autografts, allografts, and pharmacological agents have several drawbacks and can not fully restore nervous system injuries. Recently, nanotechnology and tissue engineering approaches have attracted many researchers to guide tissue regeneration in an effective manner. Owing to their remarkable physicochemical and biological properties, two-dimensional (2D) nanomaterials have been extensively studied in the tissue engineering and regenerative medicine field. The great conductivity of these materials makes them a promising candidate for the development of novel scaffolds for neural tissue engineering application. Moreover, the high loading capacity of 2D nanomaterials also has attracted many researchers to utilize them as a drug/gene delivery method to treat various devastating nervous system disorders. This review will first introduce the fundamental physicochemical properties of 2D nanomaterials used in biomedicine and the supporting biological properties of 2D nanomaterials for inducing neuroregeneration, including their biocompatibility on neural cells, the ability to promote the neural differentiation of stem cells, and their immunomodulatory properties which are beneficial for alleviating chronic inflammation at the site of the nervous system injury. It also discusses various types of 2D nanomaterials-based scaffolds for neural tissue engineering applications. Then, the latest progress on the use of 2D nanomaterials for nervous system disorder treatment is summarized. Finally, a discussion of the challenges and prospects of 2D nanomaterials-based applications in neural tissue engineering is provided.

Large bone defects caused by bone-related diseases and traumatic injuries can disrupt the self-healing potential of bone tissue. Mesenchymal stem cells (MSCs) are known as promising cell sources for bone tissue regeneration. Graphene oxide (GO), a derivative of graphene, has been recently used for controlling the differentiation of stem cells towards bone-forming cells. However, the effect of GO on the intracellular redox system in MSCs is still unknown. In this study, we found that low-dose GO nanosheets (0.1 μg mL-1) did not affect the viability and slightly increased the proliferation of BM-MSCs. Moreover, they could also maintain the redox balance by upregulating the antioxidant genes such as MnSOD and catalase during osteogenic differentiation. The osteoinductive and antioxidative effects of the low-dose GO nanosheets were regulated by the activation and nuclear localization of FoxO1, and its activation was dependent on the JNK activity. The blockade of JNK activity by SP600125 inhibited the nuclear translocation of FoxO1, and subsequently suppressed the osteogenic differentiation and antioxidant defense system of BM-MSCs. Overall, our results show that the osteoinductive and antioxidative effects of low-dose GO nanosheets occur through the activation of the JNK and FoxO1 signaling pathways.

Hypertension can cause serious health condition such as heart attack, kidney failure and stroke. A person's blood pressure is considered hypertensive if it is 140/90 mmHg, and 139/89 mmHg is called pre-hypertension. An increase of 20 mmHg systolic blood pressure or 10 mmHg diastolic blood pressure can increase the risk of death from ischemic heart disease and stroke. Living a healthy lifestyle for at least 4-6 months has been shown to lower blood pressure and can lower the risk of cardiovascular problems. The recommended healthy lifestyles include weight loss, reducing salt intake, exercise, reducing alcohol consumption, and quitting smoking. Lifestyle is an important risk factor for hypertension in young adult. The team leader visited the cadres at the village office to convey the objectives of the service activities. The distribution of invitations was carried out by cadres from Kelurahan Tomang and Kelurahan Grogol. Participants registered and then filled out a questionnaire. Then they were directed to check blood pressure. After that, participants filled out the questionnaire and watch the exercise demo. This service activity involves Medical students of the Tarumanagara University. The number of residents who participated in this event were in total of 181 residents from Tomang and Grogol, West Jakarta. The results of blood pressure measurements, found that 88.4% of residents had blood pressure classified as normal. The mean systolic blood pressure was 130.82 mmHg, and the diastolic blood pressure 77.69 mmHg. Continuous efforts are needed in the form of counseling to continue to increase hypertension awareness.ABSTRAK:Hipertensi adalah faktor penyebab timbulnya penyakit berat seperti serangan jantung, gagal ginjal dan stoke. Tekanan darah orang dikatakan hipertensi apabila 140/90 mmHg dan 139/89 mmHg disebut prahipertensi. Peningkatan 20 mmHg tekanan darah sistolik atau 10 mmHg tekanan darah diastolik dapat meningkatkan risiko kematian akibat penyakit jantung iskemik dan stroke. Menjalankan pola hidup sehat setidaknya selama 4–6 bulan terbukti dapat menurunkan tekanan darah dan secara umum dapat menurunkan risiko permasalahan kardiovaskular. Beberapa pola hidup sehat yang dianjurkan di antaranya penurunan berat badan, mengurangi asupan garam, olahraga, mengurangi konsumsi alkohol, dan berhenti merokok. Gaya hidup merupakan faktor risiko penting timbulnya hipertensi pada seseorang di usia dewasa muda. Pada hari yang telah disepakati, ketua tim melakukan kunjungan kepada para kader di kantor kelurahan untuk menyampaikan tujuan kegiatan pengabdian. Selanjutnya, penyebaran undangan dilakukan oleh para kader dari Kelurahan Tomang dan Kelurahan Grogol. Pada hari pelaksanaan, peserta melakukan registrasi dan kemudian mengisi kuesioner. Selanjutnya peserta diarahkan untuk pemeriksaan tekanan darah. Setelah pengukuran tekanan darah, peserta dikumpulkan kembali untuk melanjutkan pengisian kuesioner dan melihat demo senam melalui video. Kegiatan pengabdian ini melibatkan mahasiswa Fakultas Kedokteran Universitas Tarumanagara. Jumlah warga yang harid sebanyak 181 warga dari Kelurahan Tomang dan Grogol Jakarta Barat, Hasil pengukuran tekanan darah, didapatkan 88,4% warga tekanan darahnya tergolong normal. Rata-rata tekanan darah sistolik adalah 130,82 mmHg, dan tekanan darah diastolik 77.69 mmHg. Diperlukan upaya berkelanjutan dalam bentuk penyuluhan untuk tetap meningkatkan kewaspadaan dan pengetahun masyarakat akan Hipertensi.

Studies showed that energy metabolism plays a pivotal role in the differentiation of stem cells. Previous studies revealed that simulated microgravity (SMG) inhibits osteogenic differentiation of mesenchymal stem cells (MSCs). However, the underlying relationship between osteogenesis and energy metabolism under SMG conditions is not fully understood. In the present study, we investigated mitochondrial oxidative phosphorylation (OXPHOS) by assessing the level of peroxisome proliferator activated receptor &gamma, coactivator 1&alpha, (PGC-1&alpha, ), mitochondrial DNA (mtDNA) copy number, mitochondrial mass and oxygen consumption rate (OCR) during osteogenesis of MSCs under SMG conditions. We found that SMG inhibited osteogenic differentiation and OXPHOS of MSCs. Moreover, the expression of sirtuin 1 (Sirt1), an important energy sensor, significantly decreased. After upregulating the expression of Sirt1 using resveratrol, an activator of Sirt1, SMG-inhibited OXPHOS and osteogenic differentiation of MSCs were recovered. Taken together, our results suggest that SMG suppresses osteogenic differentiation of MSCs by inhibiting OXPHOS, indicating that OXPHOS might serve as a potential therapeutic target for repairing bone loss under microgravity conditions.

Latar Belakang: Badan Kesehatan Dunia, WHO, mendefinisikan obesitas sebagai kondisi akumulasi lemak yang berlebihan.Menurut laporan Riskesdas tahun 2013, provinsi DKI Jakarta merupakan provinsi dengan prevalensi gemuk pada remaja tertinggi (4,2%). Salah satu faktor resiko penyebab obesitas pada remaja adalah asupan gula di dalam minuman. Penelitian ini bertujuan untuk melihat hubungan antara asupan gula pada minuman oleh remaja berusia 15-19 tahun dengan obesitas di Jakarta Barat. Metode: Penelitian merupakan penelitian analitik dengan desain potong-lintang dan dianalisis menggunakan uji kai-kudrat Hasil: Dari 224 siswa didapatkan 38,4% mengalami obesitas, dan sebanyak 25% siswa asupan gula dalam minumannya lebih dari rekomendasi yang dianjurkan. Didapatkan hubungan antara asupan gula dalam minuman dengan kejadian obesitas pada remaja yang bermakna secara statistik (p

Pubertas adalah masa perubahan antara masa kanak-kanak dengan remaja, ditandai dengan perubahan jasmani yang dinamis sehingga menyebabkan perubahan fisik, psikologis dan perilaku. Pubertas pada seorang perempuan diawali dengan thelarce, kemudian pubarche, dan memuncak dengan terjadinya menarche. Pada tahun 2010 berdasarkan Riset Kesehatan Dasar di Kalimantan Barat didapatkan sebanyak 20,5% anak perempuan mengalami menarche dini terjadi pada usia 11-12 tahun, dan sebanyak 0,7% terjadi pada usia 9-10 tahun. Berdasarkan tinjauan Pustaka, olahraga, obesitas, dan asupan makanan seperti junk food merupakan faktor-faktor yang berperan terhadap menarche dini. Penelitian ini bertujuan untuk melihat hubungan antara olahraga, status gizi dan asupan junk food terhadap kejadian menarche dini pada siswi SMP di Kalimantan Barat. Penelitian ini bersifat analitik dengan desain potong lintang, dan pengambilan sampel dilakukan secara consecutive sampling. Subyek penelitian berjumlah 117 siswi. Pengumpulan data dilakukan dengan kuesioner online. Hasil analisis Chi-Square didapatkan hubungan antara menarche dini dengan status gizi lebih-obese (p0,05) dan asupan gula (p>0,05). Kesimpulan didapatkan bahwa menarche dini dipengaruhi oleh faktor seperti status gizi lebih-obese, frekuensi asupan junk-food yang berlebihan dan asupan lemak.

Penyakit tidak menular (PTM) khususnya hipertensi dan penyakit kardiovaskuler telah menjadi penyebab kematian tertinggi di dunia dengan angka mortalitas 9 juta kematian (44% dari semua kematian penyakit tidak menular dan 31% dari semua penyebab kematian global). Tujuan penelitian untuk mengetahui keterkaitan antara obesitas dan hipertensi serta keeratan mereka berdua terhadap tingginya angka mortalitas di Indonesia yang sebenarnya dapat dicegah dan ditanggulangi. Metode yang digunakan dengan Potong lintang pada masyarakat RW 05 Kelurahan Kedaung Kaliangke, serta data penelitian di uji dengan uji Chi-square, Independent T-Test, dan Mann Whitney. Hasil Penelitian menunjukan 40 responden yang memenuhi kriteria inklusi. Terdapat hubungan yang bermakna antara kejadian Indeks Massa Tubuh berlebih (obesitas) dengan kejadian hipertensi dan peningkatan tekanan darah (CI 95%: 2,286 (1,210 – 4,318) kali dan 17,9 (6,54) (4,67 – 31,13) mmHg untuk sistolik serta 8,8 (3,95) (0,80 – 16,8) mmHg untuk diastolik). Disisi lain ditemukan tidak terdapat hubungan yang bermakna secara statistik antara lingkar perut yang berlebih dengan kejadian hipertensi dan peningkatan tekanan darah, walaupun secara resiko didapatkan kejadian hipertensi dan peningkatan tekanan darah lebih tinggi pada kelompok dengan lingkar perut yang besar. (CI 95% : 2,222 (0,834-5,921) kali dan 15,33 (7,87) (-0,61 – 31,27) mmHg untuk sistolik serta 4,87 (4,79) (-4,83 – 14,56) mmHg untuk diastolik). Kesimpulan bahwa Obesitas merupakan salah satu faktor pencetus kejadian hipertensi dikemudian hari.

Increasing the welfare of the community has an impact on lifestyle changes such as low physical activity, high carbohydrate, and low diet. Along with these conditions, the incidence of non-communicable diseases (PTM / Non-Communicable Diseases / NCD) also increases. PTM includes cardiovascular disease, diabetes mellitus, lung disease, and cancer. WHO reports that each year PTM causes 35 million deaths worldwide, and many of these deaths occur in low-to-middle income economies. Obesity is one of the risk factors for PTM. Many residents of Tomang village are known to suffer from diabetes. Based on the above conditions, the Faculty of Medicine intends to carry out anthropometric and biochemical profiles to get a picture of the nutritional status and PTM in Tomang village. The invitation was distributed by cadres from Tomang Urban Village. On the day of implementation, participants registered and then filed out the questionnaire. Furthermore, participants were directed to anthropometric examination and continued with biochemical examination. This dedication activity involved the Tarumanagara University Faculty of Medicine students. From eighty-three residents, only 10.8% of residents had high blood pressure (hypertension), high blood sugar (GDS) (> 200 mg / dL) 4.8%, high cholesterol (> 200 mg / dL) 16 , 9%, and high uric acid (male> 7 mg / dL; female> 6 mg / dL) 25.3%. Based on the calculation of the Body Mass Index (BMI), it was found that more than sixty percent of the population had more nutritional status to fat. Continuous efforts are needed in the form of outreach to continue to increase community awareness and knowledge of PTMABSTRAK:Peningkatan kesejahteraan masyarakat berdampak terhadap perubahan gaya hidup seperti aktifitas fisik yang rendah, pola makan tinggi energi dan rendah serta. Seiring dengan keadaan tersebut, insiden penyakit tidak menular (PTM/Non-Communicable Diseases/NCD) ikut meningkat. PTM mencakup penyakit kardiovaskuler, diabetes melitus, penyakit paru dan kanker. WHO melaporkan setiap tahunnya PTM menyebabkan 35 juta kematian di seluruh dunia, dan kematian ini banyak terjadi di negara berpendapatan ekonomi rendah hingga sedang. Obesitas merupakan salah satu faktor resiko terjadinya PTM. Banyak warga kelurahan Tomang diketahui menderita Diabetes. Berdasarkan kondisi diatas, Fakultas Kedokteran hendak melaksanakan pemeriksaan antropometri dan profil biokimia untuk mendapatkan gambaran mengenai status gizi dan PTM di kelurahan Tomang. Penyebaran undangan dilakukan oleh para kader dari Kelurahan Tomang. Pada hari pelaksanaan, peserta melakukan registrasi dan kemudian mengisi kuesioner. Selanjutnya peserta diarahkan untuk pemeriksaan antropometri, dan dilanjutkan dengan pemeriksaan biokimia. Kegiatan pengabdian ini melibatkan mahasiswa Fakultas Kedokteran Universitas Tarumanagara. Dari delapan puluh tiga warga, didapatkan hanya 10,8% warga yang tekanan darahnya tinggi (hipertensi), gula darah sewaktu (GDS) tinggi (>200 mg/dL) 4,8%, kolesterol tinggi (>200 mg/dL) 16,9%, dan asam urat tinggi (laki-laki >7 mg/dL; perempuan >6 mg/dL) 25,3%. Berdasarkan perhitungan Indeks Massa Tubuh (IMT), didapatkan lebih dari enampuluh persen warga memiliki status gizi lebih hingga gemuk. Diperlukan upaya berkelanjutan dalam bentuk penyuluhan untuk tetap meningkatkan kewaspadaan dan pengetahun masyarakat akan PTM

These day the number of school-age children who suffer from obesity has doubled compared to 2010. Children who are obese tend to remain obese in adulthood and are at risk of suffering from various non-communicable diseases such as heart and blood vessel disease, metabolic syndrome, diabetes, and others. Based on these conditions in an effort to prevent obesity early which is one of the factors causing non-communicable diseases, it is necessary to check the nutritional status of high school students who are classified as adolescents. Activities include data collection on student identity, snack food patterns, types of snacks, and daily student activities and followed by measurements of body weight, height, and waist circumference to get an overview of the nutritional status of students. This dedication activity involved the Tarumanagara University Faculty of Medicine students. The results of the examination found that most of the 48 students and 37 students who had been assessed for nutritional status experienced height based on age (TB / U) within normal limits. As many as 34.1% of adolescents are overweight and overweight. The percentage of overweight and obesity in adolescents is quite large compared to nationally, urban, or in DKI Jaya. The mean waist circumference (Lp) 31.25% of male adolescents were found to be above the normal limit indicating excess fat in the abdominal area, while the average Lp of adolescent girls was still within normal limits. In terms of daily activities which are one of the factors causing obesity, 67.1% of adolescents engage in sports activities, but many hours are also used to use gadgets, which are about five hours per day. Most (94.1%) of adolescents consume various kinds of snacks including biscuits, chips, nuts, and fruit. Based on the results obtained, it is necessary to assess nutritional status regularly and also counseling about a healthy lifestyle.ABSTRAK:Dewasa ini jumlah anak umur sekolah yang menderita obesitas mengalami peningkatan dua kali lipat dibandingkan tahun 2010. Anak-anak yang obes cenderung untuk tetap obes di umur dewasa dan berisiko menderita berbagai penyakit tidak menular seperti penyakit jantung dan pembuluh darah, sindrom metabolik, diabetes, dan sebagainya. Berdasarkan keadaan tersebut dalam upaya pencegahan secara dini terjadinya obesitas yang merupakan salah satu faktor penyebab penyakit tidak menular, perlu dilakukan pemeriksaan status gizi pada siswa siswi sekolah menengah atas yang merupakan tergolong umur remaja. Kegiatan meliputi pendataan identitas siswa, pola makanan cemilan, jenis cemilan, dan aktifitas siswa sehari-hari dan dilanjutkan dengan pengukuran berat badan, tinggi badan dan lingkar pinggang untuk mendapatkan gambaran status gizi siswa. Kegiatan pengabdian ini melibatkan mahasiswa Fakultas Kedokteran Universitas Tarumanagara. Hasil pemeriksaan didapatkan bahwa sebagian besar dari 48 siswa dan 37 siswi yang telah dilakukan penilaian status gizi mengalami tinggi badan berdasarkan umur (TB/U) dalam batas normal. Sebanyak 34,1% remaja mengalami berat badan berlebih dan kegemukan. Persentase kelebihan berat badan dan obesitas pada remaja ini cukup besar dibandingkan secara nasional, perkotaan ataupun di DKI Jaya. Rerata lingkar pinggang (Lp) 31,25% remaja laki-laki didapatkan sudah di atas batas normal yang menunjukkan adanya kelebihan lemak di daerah perut, sedangkan rerata Lp remaja perempuan masih dalam batas normal. Ditinjau dari aktivitas sehari-hari yang merupakan salah satu fator penyebab kegemukan didapatkan sebesar 67,1% remaja melakukan aktivitas olah raga, namun tidak sedikit juga waktu yang digunakan untuk menggunakan gadget yaitu sekitar lima jam per hari. Sebagian besar (94,1%) remaja mengonsumsi bermacam macam cemilan meliputi biskuit, chips, kacang dan buah. Berdasarkan hasil yang didapat perlu dilakukan penilaian status gizi secara rutin dan juga penyuluhan tentang gaya hidup yang sehat.

Due to the ability to differentiate into variety of cell types, mesenchymal stem cells (MSCs) hold promise as source in cell-based therapy for treating injured tissue and degenerative diseases. The potential use of MSCs to replace or repair damaged tissues may depend on the efficient differentiation protocols to derive specialized cells without any negative side effects. Identification of appropriate cues that support the lineage-specific differentiation of stem cells is critical for tissue healing and cellular therapy. Recently, a number of stimuli have been utilized to direct the differentiation of stem cells. Biochemical stimuli such as small molecule, growth factor and miRNA have been traditionally used to regulate the fate of stem cells. In recent years, many studies have reported that biophysical stimuli including cyclic mechanical strain, fluid shear stress, microgravity, electrical stimulation, matrix stiffness and topography can also be sensed by stem cells through mechanical receptors, thus affecting the stem cell behaviors including their differentiation potential. In this paper, we review all the most recent literature on the application of biochemical and biophysical cues on regulating MSC differentiation. An extensive literature search was done using electronic database (Medline/Pubmed). Although there are still some challenges that need to be taken into consideration before translating these methods into clinics, biochemical and biophysical stimulation appears to be an attractive method to manipulate the lineage commitment of MSCs.

Penambahan umur harapan hidup menyebabkan peningkatan populasi lanjut usia (lansia) yang berpengaruh terhadap angka kejadian penyakit degeneratif seperti sindrom metabolik. Sindrom metabolik adalah kumpulan gangguan metabolik seperti hipertrigliserida, hyper-low-density lipoprotein (LDL), hypo-high-density lipoprotein (HDL), resistensi insulin, gangguan toleransi glukosa, hipertensi dan abdominal obesity. Prevalensi sindrom metabolik pada dekade terakhir dilaporkan meningkat terutama di negara berkembang. Tindakan preventif yang dapat dilakukan untuk menurunkan angka kejadian sindrom metabolik adalah dengan melakukan pemeriksaan kesehatan dini. Komisi kesehatan Keuskupan Agung Jakarta (KK KAJ) adalah upaya peningkatan kesehatan masyarakat melalui pengembangan program preventif seperti pemeriksaan kesehatan. Dari uraian tersebut kami bekerja sama dengan KK KAJ menyelenggarakan kegiatan PKM berupa pemeriksaan kesehatan dalam bentuk pemeriksaan fisik dan pemeriksaan darah dengan target peserta lansia untuk mendeteksi adanya sindrom metabolik sehingga dapat mengurangi angka resiko kecacatan dan kematian. Pemeriksaan fisik yang dilakukan dalam kegiatan ini adalah pemeriksaan tekanan darah. Sedangkan pemeriksaan darah yang dilakukan mencakup pemeriksaan gula darah dan kolesterol seperti glukosa darah, HDL, LDL dan trigliserida. Peserta yang telah melakukan pemeriksaan darah dapat berkonsultasi dengan tim dokter untuk menginterpretasikan hasil pemeriksaan. Jumlah peserta yang berpartisipasi pada kegiatan ini adalah 320 peserta. Hasil yang dicapai dari kegiatan ini adalah peserta mengetahui hasil pemeriksaan kesehatan baik pemeriksaan fisik maupun pemeriksaan darah yang dapat menggambarkan status kesehatan peserta. Dengan diketahuinya status kesehatan diri sendiri, diharapkan dapat meningkatkan kewaspadaan diri terhadap sindrom metabolik baik melalui tindakan promotif dan preventif.

Angiogenesis, a process of new blood vessel formation from existing blood vessels, plays an important role in tumor growth and the tissue repair process. It is generally acknowledged that angiogenesis might contribute two both processes. In tumor growth, angiogenesis often increases oncogenic signaling, and in tissue repair, it decreases the stiffness of wound tissue and potentially exacerbates scar formation, resulting in pain and poor function. These poor outcomes are due to an increase in the expression of important genes involved in angiogenesis, such as hypoxia-inducible factor-1 alpha (HIF-1α) and its transcriptional target vascular endothelial growth factor (VEGF). Therefore, this adverse effect of angiogenesis should be taken into consideration. Limiting vessel growth instead of boosting growth may be beneficial for favorable long-term healing outcomes. Posttranslational modifications, including acetylation, which is mediated by histone acetyltransferases, and deacetylation, which is mediated by histone deacetylases (HDACs), are critical to HIF-1α function. Most studies have indicated that HDAC inhibitors (HDACIs) show great promise as antiangiogenic agents in the early phase of clinical trials. In this review, we discuss the role of the HDACs HIF-1α and VEGF in angiogenesis. Furthermore, we also discuss the molecular and cellular underpinnings of the effects of HDACIs on antiangiogenesis, which creates new avenues for anticancer therapeutics and the repair of wounded tissue.

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by the Coronavirus of the genus Severe Acute Respiratory Syndrome Human Corona virus (SARS-HCoV). Transmission of this disease occurs through close contact, especially through respiratory droplets when the patient coughs or sneezes. Most people with this disease recover spontaneously, but some experience a fatal worsening including organ failure, septic shock, pulmonary edema, severe pneumonia and acute respiratory distress syndrome (ARDS). Breaking the chain of transmission is the key to stopping the spread of this disease. The World Health Organization, WHO, said that there are three things that can be done to prevent the spread of this disease, namely by keeping a distance, not being in a closed room, and limiting mobilization (not gathering). Increasing body immunity by implementing a clean and healthy lifestyle (PHBS) such as consuming balanced nutrition, physical activity for at least 30 minutes a day, adequate rest, utilizing traditional health are part of disease prevention measures. Changes in the learning system during the pandemic made students easily exposed to various incorrect information. Efforts are needed to explain to students to increase students' awareness of the Covid-19 disease and its prevention stepsCoronavirus Disease 2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh virus Coronavirus dari genus Severe Acute Respiratory Syndrome Human Coronarvirus (SARS-HCoV). Penularan penyakit ini terjadi kontak erat terutama melalui droplets saluran napas saat penderita batuk atau bersin. Sebagian besar penderita penyakit ini sembuh secara spontan, namun beberapa mengalami perburukan yang fatal mencakup gagal organ, syok septik, edema paru-paru, pneumonia berat dan sindrom gagal napas akut (acute respiratory distress syndrome/ARDS). Pemutusan rantai penularan merupakan kunci untuk menghentikan penyebaran penyakit ini. Organisasi Kesehatan Dunia, WHO, menyampaikan ada tiga hal yang dapat dilakukan untuk mencegah penyebaran penyakit ini yaitu dengan menjaga jarak, tidak berada dalam ruangan tertutup, dan membatasi mobilisasi (tidak berkumpul). Meningkatkan daya tahan tubuh dengan menerapkan pola hidup bersih sehat (PHBS) seperti mengonsumsi gizi seimbang, beraktivitas fisik minimal 30 menit sehari, istirahat yang cukup, memanfaatkan kesehatan tradisional merupakan bagian dari langkah-langkah pencegahan penyakit. Perubahan sistem pembelajaran selama Pandemi berlangsung membuat siswa mudah terpapar dengan berbagai informasi yang tidak benar. Diperlukan upaya penjelasan pada para siswa untuk meningkatkan kesadaran para siswa terhadap penyakit Covid-19 dan langkah-langkah pencegahannya.