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The Antiangiogenesis Role of Histone Deacetylase Inhibitors: Their Potential Application to Tumor Therapy and Tissue Repair
- Source :
- DNA and cell biology. 39(2)
- Publication Year :
- 2019
-
Abstract
- Angiogenesis, a process of new blood vessel formation from existing blood vessels, plays an important role in tumor growth and the tissue repair process. It is generally acknowledged that angiogenesis might contribute two both processes. In tumor growth, angiogenesis often increases oncogenic signaling, and in tissue repair, it decreases the stiffness of wound tissue and potentially exacerbates scar formation, resulting in pain and poor function. These poor outcomes are due to an increase in the expression of important genes involved in angiogenesis, such as hypoxia-inducible factor-1 alpha (HIF-1α) and its transcriptional target vascular endothelial growth factor (VEGF). Therefore, this adverse effect of angiogenesis should be taken into consideration. Limiting vessel growth instead of boosting growth may be beneficial for favorable long-term healing outcomes. Posttranslational modifications, including acetylation, which is mediated by histone acetyltransferases, and deacetylation, which is mediated by histone deacetylases (HDACs), are critical to HIF-1α function. Most studies have indicated that HDAC inhibitors (HDACIs) show great promise as antiangiogenic agents in the early phase of clinical trials. In this review, we discuss the role of the HDACs HIF-1α and VEGF in angiogenesis. Furthermore, we also discuss the molecular and cellular underpinnings of the effects of HDACIs on antiangiogenesis, which creates new avenues for anticancer therapeutics and the repair of wounded tissue.
- Subjects :
- 0301 basic medicine
Vascular Endothelial Growth Factor A
Angiogenesis
Histone Deacetylases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Genetics
medicine
Animals
Humans
Molecular Biology
Histone Acetyltransferases
biology
Neovascularization, Pathologic
Cell Biology
General Medicine
Cell Hypoxia
Vascular endothelial growth factor
Histone Deacetylase Inhibitors
030104 developmental biology
Histone
medicine.anatomical_structure
chemistry
Acetylation
030220 oncology & carcinogenesis
biology.protein
Cancer research
Angiogenesis Inducing Agents
Histone deacetylase
Function (biology)
Blood vessel
Subjects
Details
- ISSN :
- 15577430
- Volume :
- 39
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- DNA and cell biology
- Accession number :
- edsair.doi.dedup.....db177a7bd8f4b9bbef91d9ec83828bd2