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The voltage gated sodium channel Na

The discovery and selection of a highly potent and selective Na

This paper investigates racial and ethnic differences in sexual attitudes, beliefs about prostitution, childhood victimization, relationship issues, and attitudes towards sexual violence against women among men arrested for soliciting sexual favors from sex workers in four American cities. Using ANOVA for means comparison, this project will make an original and significant contribution to criminal justice policies that address clients of prostitutes rather than prostitutes themselves. Diversion programs such as the one employed in the cities under investigation must take into account the importance of culturally based differences among prostitute clients along the lines of race/ethnicity, attitudes toward women, and by extension female sex workers, and the sexual scripts they use in their interactions with prostitute women. This analysis will be important in the development of programs, training and education modules, as well as making a contribution to the paucity of literature in the social and...

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms.

A series of 4-substituted pyrimido[4,5-d]azepines that are potent, selective 5-HT2C receptor partial agonists is described. A rational medicinal chemistry design strategy to deliver CNS penetration coupled with SAR-based optimization of selectivity and agonist potency provided compounds with the desired balance of preclinical properties. Lead compounds 17 (PF-4479745) and 18 (PF-4522654) displayed robust pharmacology in a preclinical canine model of stress urinary incontinence (SUI) and no measurable functional agonism at the key selectivity targets 5-HT2A and 5-HT2B in relevant tissue-based assay systems. Utilizing recent advances in the structural biology of GPCRs, homology modeling has been carried out to rationalize binding and agonist efficacy of these compounds.

The Fridtjof Nansen Institute has an uncanny sense of timing. Its long and influential association with the Antarctic and other polar concerns owes something to its organisation of conferences such as this at important points in the evolution of polar affairs. In 1973 the meeting of experts it convened to consider the authorisation or prohibition of Antarctic mineral exploration was the first thorough exchange of views on this topic. That seminal discussion influenced the course of events. We can expect that the present conference will also do so.

The B-Me-(S)-CBS catalysed borane reduction of centrosymmetric bis-N-Boc tetrahydro photodimer 3 has been achieved with virtually complete enantiotopic group selectivity (>97% ee) and in good yield (76%).