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Highly potent and selective Na
- Source :
- Bioorganicmedicinal chemistry letters. 27(21)
- Publication Year :
- 2017
-
Abstract
- The discovery and selection of a highly potent and selective Na
- Subjects :
- Voltage-Gated Sodium Channel Blockers
Sulfonamides
Binding Sites
Pyridines
NAV1.7 Voltage-Gated Sodium Channel
Pain
Protein Structure, Tertiary
Rats
Molecular Docking Simulation
Inhibitory Concentration 50
Mice
Structure-Activity Relationship
Dogs
Piperidines
Thiadiazoles
Hepatocytes
Microsomes, Liver
Animals
Humans
Infusions, Intravenous
Half-Life
Protein Binding
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 27
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.pmid..........9b1525a17645ac5a672b8a43ff63d92d